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ZP3 Gene

protein-coding   GIFtS: 57
GCID: GC07P076026

Zona Pellucida Glycoprotein 3 (Sperm Receptor)

(Previous name: zona pellucida glycoprotein 3A (sperm receptor))
(Previous symbols: ZP3A, ZP3B)
  See ZP3-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zona Pellucida Glycoprotein 3 (Sperm Receptor)1 2     ZPC2 3
ZP3A1 2 3 5     Zp-32 3
ZP3B1 2 3 5     Zona Pellucida Glycoprotein 3B2
Zona Pellucida Glycoprotein 3A (Sperm Receptor)1 2     Zona Pellucida Glycoprotein ZP32
Sperm Receptor2 3     Zona Pellucida Sperm-Binding Protein 32
Zona Pellucida Protein C2 3     Zona Pellucida Glycoprotein 33
ZP3A/ZP3B2 3     

External Ids:    HGNC: 131891   Entrez Gene: 77842   Ensembl: ENSG000001883727   OMIM: 1828895   UniProtKB: P217543   

Export aliases for ZP3 gene to outside databases

Previous GC identifers: GC07P074589 GC07P071749 GC07P071763 GC07P075638 GC07P075671 GC07P075864 GC07P071113


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ZP3 Gene:
The zona pellucida is an extracellular matrix that surrounds the oocyte and early embryo. It is composed primarily
of three or four glycoproteins with various functions during fertilization and preimplantation development. The
protein encoded by this gene is a structural component of the zona pellucida and functions in primary binding and
induction of the sperm acrosome reaction. The nascent protein contains a N-terminal signal peptide sequence, a
conserved ZP domain, a C-terminal consensus furin cleavage site, and a transmembrane domain. It is hypothesized
that furin cleavage results in release of the mature protein from the plasma membrane for subsequent
incorporation into the zona pellucida matrix. However, the requirement for furin cleavage in this process remains
controversial based on mouse studies. A variation in the last exon of this gene has previously served as the
basis for an additional ZP3 locus; however, sequence and literature review reveals that there is only one
full-length ZP3 locus in the human genome. Another locus encoding a bipartite transcript designated POMZP3
contains a duplication of the last four exons of ZP3, including the above described variation, and maps closely
to this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for ZP3 Gene:
ZP3 (zona pellucida glycoprotein 3 (sperm receptor)) is a protein-coding gene. Diseases associated with ZP3 include oophoritis. GO annotations related to this gene include store-operated calcium channel activity and signal transducer activity. An important paralog of this gene is POMZP3.

UniProtKB/Swiss-Prot: ZP3_HUMAN, P21754
Function: The mammalian zona pellucida, which mediates species-specific sperm binding, induction of the acrosome
reaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, ZP1, ZP2, ZP3,
and ZP4. ZP3 is essential for sperm binding and zona matrix formation

Gene Wiki entry for ZP3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000007.13  NC_018918.2  NT_007933.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZP3 gene promoter:
         E2F-4   E2F-3a   SRY   E2F-1   E2F   E2F-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): ZP3 promoter sequence
   Search Chromatin IP Primers for ZP3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZP3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q11.23   Ensembl cytogenetic band:  7q11.23   HGNC cytogenetic band: 7q11.23

ZP3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZP3 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P076026:  view genomic region     (about GC identifiers)

Start:
76,026,835 bp from pter      End:
76,071,388 bp from pter
Size:
44,554 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 75,359,905-75,404,452     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ZP3_HUMAN, P21754 (See protein sequence)
Recommended Name: Zona pellucida sperm-binding protein 3 precursor  
Size: 424 amino acids; 47018 Da
Subunit: Polymers of ZP2 and ZP3 organized into long filaments cross-linked by ZP1 homodimers (By similarity)
Secondary accessions: Q06633 Q29RW0
Alternative splicing: 3 isoforms:  P21754-1   P21754-2   P21754-3   (Found in a second polymorphic locus which, due to an extra G residue in exon 8, has the potential to encode a truncated protein of 372 amino acids)

Explore the universe of human proteins at neXtProt for ZP3: NX_P21754

Explore proteomics data for ZP3 at MOPED

Post-translational modifications: 

  • Proteolytically cleaved before the transmembrane segment to yield the secreted ectodomain incorporated in the zona
    pellucida1
  • N-glycosylated (By similarity)1
  • O-glycosylated; removal of O-linked glycans may play an important role in the post-fertilization block to
    polyspermy (By similarity)1
  • Glycosylation2 at Asn125, Asn147, Thr156, Thr162, Thr163, Asn272
  • Modification sites at PhosphoSitePlus

  • See ZP3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001103824.1  NP_009086.4  

    ENSEMBL proteins: 
     ENSP00000337310   ENSP00000378326   ENSP00000411955   ENSP00000378329  
    Reactome Protein details: P21754

    ZP3 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZP: Zona pellucida glycoproteins

    2 InterPro protein domains:
     IPR017977 ZP_dom_CS
     IPR001507 ZP_dom

    Graphical View of Domain Structure for InterPro Entry P21754

    ProtoNet protein and cluster: P21754

    1 Blocks protein domain: IPB001507 Endoglin/CD105 antigen

    UniProtKB/Swiss-Prot: ZP3_HUMAN, P21754
    Domain: The ZP domain is involved in the polymerization of the ZP proteins to form the zona pellucida
    Similarity: Belongs to the ZP domain family. ZPC subfamily
    Similarity: Contains 1 ZP domain


    Find genes that share domains with ZP3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZP3_HUMAN, P21754
    Function: The mammalian zona pellucida, which mediates species-specific sperm binding, induction of the acrosome
    reaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, ZP1, ZP2, ZP3,
    and ZP4. ZP3 is essential for sperm binding and zona matrix formation

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004871signal transducer activity IMP18667750
    GO:0005384manganese ion transmembrane transporter activity ISS--
    GO:0005515protein binding IPI19945174
    GO:0015279store-operated calcium channel activity IDA--
    GO:0030246carbohydrate binding IDA19246320
         
    Find genes that share ontologies with ZP3           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for ZP3:
     Synthetic lethal with imatinib 

         4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Zp3):
     cellular  embryogenesis  endocrine/exocrine gland  reproductive system 

    Find genes that share phenotypes with ZP3           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for ZP3: Zp3tm1Dean Zp3tm1Pmw

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ZP3
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    miRNA
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    hsa-mir-7-5p (MIRT025811)

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    Addgene plasmids for ZP3 

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZP3_HUMAN, P21754: Processed zona pellucida sperm-binding protein 3: Secreted, extracellular space,
    extracellular matrix. Note=The glycoproteinaceous translucent extracellular matrix that surrounds the mammalian
    oocyte is called zona pellucida
    ZP3_HUMAN, P21754: Cell membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    plasma membrane5
    endoplasmic reticulum4
    endosome4
    golgi apparatus4
    nucleus1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001669colocalizes with acrosomal vesicle ISS--
    GO:0002081outer acrosomal membrane ISS--
    GO:0005576extracellular region TAS--
    GO:0005578proteinaceous extracellular matrix IEA--
    GO:0005615extracellular space IMP19246320

    Find genes that share ontologies with ZP3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ZP3 About    
    See pathways by source

    SuperPathContained pathways About
    1Reproduction
    Reproduction1.00
    Interaction With The Zona Pellucida0.00
    Fertilization1.00
    2Sweet Taste Signaling
    Sperm Motility0.37
    3Ovarian Infertility Genes
    Ovarian Infertility Genes


    Find genes that share SuperPaths with ZP3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for ZP3
        Sperm Motility

    1 BioSystems Pathway for ZP3
        Ovarian Infertility Genes

    1 Reactome Pathway for ZP3
        Interaction With The Zona Pellucida


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZP3
    Interactions:

        Search GeneGlobe Interaction Network for ZP3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    Selected Interacting proteins for ZP3 (P217543 ENSP000003783264) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ACRP103233, ENSP000002161394I2D: score=2 STRING: ENSP00000216139
    C4BPAP040033, ENSP000003560374I2D: score=1 STRING: ENSP00000356037
    FURINP099583, ENSP000002681714I2D: score=1 STRING: ENSP00000268171
    ENGASEQ8NFI33, ENSP000003006824I2D: score=1 STRING: ENSP00000300682
    UBAP2LENSP000003553434STRING: ENSP00000355343
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 32):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001809positive regulation of type IV hypersensitivity ISS--
    GO:0001825blastocyst formation ISS--
    GO:0002455humoral immune response mediated by circulating immunoglobulin ISS--
    GO:0002687positive regulation of leukocyte migration ISS--
    GO:0002922positive regulation of humoral immune response IDA19004505

    Find genes that share ontologies with ZP3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZP3

    9 Novoseek inferred chemical compound relationships for ZP3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    mannose 30.9 2 7507936 (1)
    calcium 24.6 4 9239670 (1), 12464273 (1), 9651467 (1), 8088433 (1)
    tyrosine 22.5 9 8045346 (2), 9665632 (1), 15317909 (1), 9872364 (1) (see all 6)
    carbohydrates 19.5 3 1311731 (1), 11358873 (1), 9225165 (1)
    cysteine 17.3 3 10216911 (1), 10216914 (1)
    progesterone 17.1 2 12464273 (1), 9651467 (1)
    serine 7.14 2 9600940 (1), 10216914 (1)
    proline 0 2 10216914 (2)
    polysaccharide 0 1 11358873 (1)



    Find genes that share compounds with ZP3           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ZP3 gene (2 alternative transcripts): 
    NM_001110354.1  NM_007155.5  

    Unigene Cluster for ZP3:

    Zona pellucida glycoprotein 3 (sperm receptor)
    Hs.656137  [show with all ESTs]
    Unigene Representative Sequence: BC113949
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000336517(uc003ufc.4) ENST00000394857(uc003ufd.4) ENST00000416245(uc003ufe.3)
    ENST00000394860 ENST00000466960 ENST00000479793 ENST00000467555
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    Additional mRNA sequence: 

    AK292763.1 BC113949.1 M60504.1 S52509.1 

    13 DOTS entries:

    DT.95145133  DT.121067326  DT.92469787  DT.100027278  DT.95145163  DT.100790706  DT.121637693  DT.95145124 
    DT.95266574  DT.95293148  DT.97769393  DT.121090535  DT.95362005 

    Selected AceView cDNA sequences (see all 159):

    BQ446470 AI802299 BF195407 CR603033 AW162786 AI075996 BF063092 BF726964 
    AI359326 CR616549 BU172163 BG460523 H22333 AI144523 BQ673059 NM_152992 
    AW163456 AA333786 CA421411 U10099 BQ961240 AA334719 AA334331 AW249685 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for ZP3    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b
    SP1:                                                      
    SP2:                                                      
    SP3:                                -     -               


    ECgene alternative splicing isoforms for ZP3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZP3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGTAGAGCA
    ZP3 Expression
    About this image


    ZP3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Ovary (Reproductive System)    fully expand to see all 8 entries
             Pre-Granulosa Cells Primordial Follicle
             Ovarian tissue-dissociated cells (human)
             Oocytes
             oocyte   
     
     Gonad
             Ovum Ovigerous Cord
             Human oogonial stem cells
     
     Germ Cells (Reproductive System)
             Human oogonial stem cells
     
     NULL (Uncategorized)
             Short-term differentiated embryoid bodies
     
     Inner Cell Mass (Early Embryonic Tissues)
             ES-J1
    ZP3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZP3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.656137

    UniProtKB/Swiss-Prot: ZP3_HUMAN, P21754
    Tissue specificity: Oocytes

        Custom PCR Arrays for ZP3
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZP3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ZP3 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zp31 , 5 zona pellucida glycoprotein 31, 5 74.54(n)1
    68.26(a)1
      5 (75.62 cM)5
    227881  NM_011776.11  NP_035906.11 
     1359800995 
    chicken
    (Gallus gallus)
    Aves ZP31 zona pellucida sperm-binding protein 3 61.78(n)
    53.53(a)
      378906  NM_204389.2  NP_989720.3 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    44(a)
    1 → many
    GL343492.1(388222-397508)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.37152 Xenopus laevis transcribed sequence with weak similarity more 73.25(n)    BX851629.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zp3a.21 zona pellucida glycoprotein 3a, tandem duplicate 2 52.13(n)
    41.49(a)
      558677  NM_001030120.1  NP_001025291.1 


    ENSEMBL Gene Tree for ZP3 (if available)
    TreeFam Gene Tree for ZP3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZP3 gene
    POMZP32  
    2 SIMAP similar genes for ZP3 using alignment to 3 protein entries:     ZP3_HUMAN (see all proteins):
    ZP3A    POMZP3

    Find genes that share paralogs with ZP3           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for ZP3
    PGOHUM00000235302 PGOHUM00000233581


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZP3 (see all 873)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs102332641,2
    C,H--76041038(+) gatacT/Cctgaa 1 -- int16Minor allele frequency- C:0.00NS EA NA 424
    rs1929065001,2
    --76041118(+) GCATTC/TATCCA 1 -- int10--------
    rs602664061,2
    C,F--76041135(+) ATGAAA/CACTTA 1 -- int14Minor allele frequency- C:0.20WA CSA 124
    rs1166812041,2
    F--76041143(+) TTACAT/CCTTCA 1 -- int11Minor allele frequency- C:0.01WA 118
    rs745704371,2
    C--76041252(+) TGCCTG/TTAGTC 1 -- int10--------
    rs102335361,2
    C--76041292(+) atcacT/Ctgagc 1 -- int14Minor allele frequency- C:0.09NA WA EA 242
    rs1178259781,2
    F--76041340(+) CTCCAA/GCTCTA 1 -- int11Minor allele frequency- G:0.01EA 120
    rs1452610461,2
    --76041344(+) AACTCA/TACAAA 1 -- int10--------
    rs733615931,2
    C,F--76041380(+) GATTCT/CTGTGG 1 -- int13Minor allele frequency- C:0.11WA CSA 122
    rs1852646391,2
    --76041397(+) CTACAC/TGAGAG 1 -- int10--------

    HapMap Linkage Disequilibrium report for ZP3 (76026835 - 76071388 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for ZP3 (see all 20):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2669174CNV Deletion23128226
    dgv120n16CNV Deletion17901297
    esv2422494CNV Duplication17116639
    dgv21n31CNV Duplication19718026
    esv2584656CNV Insertion19546169
    dgv233e55CNV Loss17911159
    nsv888387CNV Loss21882294
    dgv235e55CNV Loss17911159
    esv33074CNV Gain17666407
    nsv428174CNV Gain18775914

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing ZP3
    DNA2.0 Custom Variant and Variant Library Synthesis for ZP3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 182889    OMIM disorders: --

    1 disease for ZP3:    
    About MalaCards
    oophoritis

    4 diseases from the University of Copenhagen DISEASES database for ZP3:
    Oophoritis     Infertility     Ovarian dysfunction     Diphtheria

    Find genes that share disorders with ZP3           About GenesLikeMe

    2 Novoseek inferred disease relationships for ZP3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ovarian dysfunction 80.7 2 10321806 (1)
    infertility 51.9 7 8984175 (1), 17936279 (1), 11730908 (1), 1576251 (1), 8962643 (1), 18547509 (1) (see top 4)

    Human Genome Epidemiology (HuGE) Navigator: ZP3 (2 documents)

    Export disorders for ZP3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZP3 gene, integrated from 10 sources (see all 136):
    (articles sorted by number of sources associating them with ZP3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of the human sperm receptor ligand ZP3: evidence for a second polymorphic allele with a different frequency in the Caucasian and Japanese populations. (PubMed id 1478648)1, 2, 3, 9 van Duin M.... Aitken R.J. (Genomics 1992)
    2. Human homolog of the mouse sperm receptor. (PubMed id 2385582)1, 2, 9 Chamberlin M.E. and Dean J. (Proc. Natl. Acad. Sci. U.S.A. 1990)
    3. Mass spectrometry analysis of recombinant human ZP3 expressed in glycosylation-deficient CHO cells. (PubMed id 15379548)1, 2, 9 Zhao M....Dean J. (Biochemistry 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Binding characteristics of sperm with recombinant human zona pellucida glycoprotein-3 coated beads. (PubMed id 19700799)1, 9 Bansal P. and Gupta S.K. (Indian J. Med. Res. 2009)
    6. Species specificity of human and murine anti-ZP3 synthetic peptide antisera and use of the antibodies for localization and identification of ZP3 or ZPC domains of functional significance. (PubMed id 10099990)1, 9 Hinsch E....Hinsch K.D. (Hum. Reprod. 1999)
    7. POM-ZP3, a bipartite transcript derived from human ZP3 and a POM121 homologue. (PubMed id 7789967)1, 9 Kipersztok S.... Dean J. (Genomics 1995)
    8. DNA vaccine encoding chimeric protein encompassing epitopes of human ZP3 and ZP4: immunogenicity and characterization of antibodies. (PubMed id 19004505)1, 9 Choudhury S....Gupta S.K. (J. Reprod. Immunol. 2009)
    9. Effects of native human zona pellucida glycoproteins 3 and 4 on acrosome reaction and zona pellucida binding of human spermatozoa. (PubMed id 18667750)1, 9 Chiu P.C....Yeung W.S. (Biol. Reprod. 2008)
    10. Functional activity of human ZP3 primary sperm receptor resides toward its C-terminus. (PubMed id 19246320)1, 9 Bansal P....Gupta S.K. (Biol. Reprod. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7784 HGNC: 13189 AceView: POMZP3 Ensembl:ENSG00000188372 euGenes: HUgn7784
    ECgene: ZP3 H-InvDB: ZP3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZP3 Pharmacogenomics, SNPs, Pathways
    Protein Spotlighthttp://web.expasy.org/spotlight/back_issues/093

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZP3 gene:
    Search GeneIP for patents involving ZP3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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