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Aliases for ZP2 Gene

Aliases for ZP2 Gene

  • Zona Pellucida Glycoprotein 2 2 3 4
  • Zona Pellucida Glycoprotein 2 (Sperm Receptor) 2 3 5
  • Zona Pellucida Protein A 3 4
  • Zp-2 3 4
  • ZPA 3 4
  • Zona Pellucida Glycoprotein ZP2 3

External Ids for ZP2 Gene

Previous GeneCards Identifiers for ZP2 Gene

  • GC16M020617
  • GC16M021217
  • GC16M021175
  • GC16M021116
  • GC16M019743
  • GC16M021208

Summaries for ZP2 Gene

Entrez Gene Summary for ZP2 Gene

  • The zona pellucida is an extracellular matrix that surrounds the oocyte and early embryo. It is composed of three glycoproteins with various functions during fertilization and preimplantation development. The glycosylated mature peptide is one of the structural components of the zona pellucida and functions in secondary binding and penetration of acrosome-reacted spermatozoa. Female mice lacking this gene do not form a stable zona matrix and are sterile. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]

GeneCards Summary for ZP2 Gene

ZP2 (Zona Pellucida Glycoprotein 2) is a Protein Coding gene. Diseases associated with ZP2 include Infertility and Acheiropody. Among its related pathways are Reproduction and Ovarian Infertility Genes. GO annotations related to this gene include coreceptor activity and acrosin binding. An important paralog of this gene is ZP1.

UniProtKB/Swiss-Prot for ZP2 Gene

  • The mammalian zona pellucida, which mediates species-specific sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP2 may act as a secondary sperm receptor.

Gene Wiki entry for ZP2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZP2 Gene

Genomics for ZP2 Gene

Regulatory Elements for ZP2 Gene

Enhancers for ZP2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZP2 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZP2 Gene

Chromosome:
16
Start:
21,197,450 bp from pter
End:
21,214,510 bp from pter
Size:
17,061 bases
Orientation:
Minus strand

Genomic View for ZP2 Gene

Genes around ZP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZP2 Gene

Proteins for ZP2 Gene

  • Protein details for ZP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q05996-ZP2_HUMAN
    Recommended name:
    Zona pellucida sperm-binding protein 2
    Protein Accession:
    Q05996
    Secondary Accessions:
    • B2R7J2
    • Q4VAN9
    • Q4VAP0
    • Q4VAP1

    Protein attributes for ZP2 Gene

    Size:
    745 amino acids
    Molecular mass:
    82357 Da
    Quaternary structure:
    • Can form homopolymers that assemble into long fibers (in vitro). Polymers of ZP2 and ZP3 organized into long filaments cross-linked by ZP1 homodimers.

    Alternative splice isoforms for ZP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZP2 Gene

Proteomics data for ZP2 Gene at MOPED

Post-translational modifications for ZP2 Gene

  • N-glycosylated.
  • O-glycosylated; contains sulfate-substituted glycans.
  • Proteolytically cleaved before the transmembrane segment to yield the secreted ectodomain incorporated in the zona pellucida.
  • Proteolytically cleaved in the N-terminal part by the metalloendopeptidase ASTL exocytosed from cortical granules after fertilization, yielding a N-terminal peptide of about 30 kDa which remains covalently attached to the C-terminal peptide via disulfide bond(s). This cleavage may play an important role in the post-fertilization block to polyspermy. Additional proteolytically cleavage of the N-terminal peptide of 30 kDa occurs in one-cell and two-cell embryos.
  • Glycosylation at Asn 87, Asn 105, Asn 122, Asn 223, Asn 269, Asn 400, and Thr 462
  • Modification sites at PhosphoSitePlus

Other Protein References for ZP2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZP2 Gene

Domains & Families for ZP2 Gene

Gene Families for ZP2 Gene

Protein Domains for ZP2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for ZP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q05996

UniProtKB/Swiss-Prot:

ZP2_HUMAN :
  • The ZP domain is involved in the polymerization of the ZP proteins to form the zona pellucida.
Domain:
  • The ZP domain is involved in the polymerization of the ZP proteins to form the zona pellucida.
  • Belongs to the ZP domain family. ZPA subfamily.
  • Contains 1 ZP domain.
genes like me logo Genes that share domains with ZP2: view

Function for ZP2 Gene

Molecular function for ZP2 Gene

GENATLAS Biochemistry:
zona pellucida glycoprotein 2 (sperm receptor)
UniProtKB/Swiss-Prot Function:
The mammalian zona pellucida, which mediates species-specific sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP2 may act as a secondary sperm receptor.

Gene Ontology (GO) - Molecular Function for ZP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032190 acrosin binding IPI 15950651
genes like me logo Genes that share ontologies with ZP2: view
genes like me logo Genes that share phenotypes with ZP2: view

Animal Models for ZP2 Gene

MGI Knock Outs for ZP2:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for ZP2 Gene

Localization for ZP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZP2 Gene

Processed zona pellucida sperm-binding protein 2: Secreted, extracellular space, extracellular matrix. Note=The glycoproteinaceous translucent extracellular matrix that surrounds the mammalian oocyte is called zona pellucida. {ECO:0000250 UniProtKB:P20239}.
Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZP2 Gene COMPARTMENTS Subcellular localization image for ZP2 gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 5
plasma membrane 5
endosome 4
golgi apparatus 4
nucleus 2
cytosol 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for ZP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005578 proteinaceous extracellular matrix IEA --
GO:0005771 multivesicular body IEA,ISS --
GO:0005886 plasma membrane IEA,ISS --
genes like me logo Genes that share ontologies with ZP2: view

Pathways & Interactions for ZP2 Gene

genes like me logo Genes that share pathways with ZP2: view

Pathways by source for ZP2 Gene

1 BioSystems pathway for ZP2 Gene

Interacting Proteins for ZP2 Gene

Selected Interacting proteins: Q05996-ZP2_HUMAN for ZP2 Gene via MINT I2D

Gene Ontology (GO) - Biological Process for ZP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006828 NOT manganese ion transport ISS --
GO:0007165 signal transduction TAS 8385033
GO:0007338 single fertilization TAS --
GO:0060046 NOT regulation of acrosome reaction IDA 11751269
GO:0060468 prevention of polyspermy IEA,ISS 22472438
genes like me logo Genes that share ontologies with ZP2: view

No data available for SIGNOR curated interactions for ZP2 Gene

Drugs & Compounds for ZP2 Gene

No Compound Related Data Available

Transcripts for ZP2 Gene

mRNA/cDNA for ZP2 Gene

(3) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZP2 Gene

Zona pellucida glycoprotein 2 (sperm receptor):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZP2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19
SP1: -
SP2: - -
SP3:

Relevant External Links for ZP2 Gene

GeneLoc Exon Structure for
ZP2
ECgene alternative splicing isoforms for
ZP2

Expression for ZP2 Gene

mRNA expression in normal human tissues for ZP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ZP2 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x25.9) and Brain - Cerebellum (x25.7).

Protein differential expression in normal tissues from HIPED for ZP2 Gene

This gene is overexpressed in Monocytes (32.7), Tlymphocyte (16.7), and Blymphocyte (15.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZP2 Gene



SOURCE GeneReport for Unigene cluster for ZP2 Gene Hs.73982

genes like me logo Genes that share expression patterns with ZP2: view

Protein tissue co-expression partners for ZP2 Gene

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for ZP2 Gene

Orthologs for ZP2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZP2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ZP2 35
  • 80.62 (n)
  • 70.22 (a)
ZP2 36
  • 70 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZP2 35
  • 80.17 (n)
  • 70.46 (a)
ZP2 36
  • 70 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zp2 35
  • 72.71 (n)
  • 61.04 (a)
Zp2 16
Zp2 36
  • 60 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ZP2 35
  • 99.51 (n)
  • 99.33 (a)
ZP2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zp2 35
  • 73.06 (n)
  • 60.9 (a)
oppossum
(Monodelphis domestica)
Mammalia ZP2 36
  • 49 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 50 (a)
OneToMany
-- 36
  • 44 (a)
OneToMany
chicken
(Gallus gallus)
Aves ZP2 35
  • 56.51 (n)
  • 44.81 (a)
ZP2 36
  • 41 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 47 (a)
OneToMany
-- 36
  • 48 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia zp2 35
  • 50.25 (n)
  • 41.6 (a)
African clawed frog
(Xenopus laevis)
Amphibia xlZPA 35
zebrafish
(Danio rerio)
Actinopterygii si:ch211-223m11.2 36
  • 14 (a)
ManyToMany
Species with no ortholog for ZP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZP2 Gene

ENSEMBL:
Gene Tree for ZP2 (if available)
TreeFam:
Gene Tree for ZP2 (if available)

Paralogs for ZP2 Gene

Paralogs for ZP2 Gene

(2) SIMAP similar genes for ZP2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ZP2: view

Variants for ZP2 Gene

Sequence variations from dbSNP and Humsavar for ZP2 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs2075520 - 21,211,351(+) AGTTC(A/C)CTGAA reference, missense
rs8064027 -- 21,213,958(+) GTCAG(A/G)GAAGT intron-variant
rs13331814 -- 21,210,003(+) TTGGA(G/T)GCCGT intron-variant
rs9921849 -- 21,215,604(+) CAAAG(C/T)GTGGA upstream-variant-2KB
rs13337812 -- 21,210,861(+) TGAGC(C/T)CCGGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZP2 Gene

Variant ID Type Subtype PubMed ID
nsv436835 CNV Insertion 17901297
nsv833166 CNV Gain+Loss 17160897
nsv509605 CNV Insertion 20534489
nsv1762 CNV Insertion 18451855
nsv905576 CNV Gain 21882294
nsv524978 CNV Loss 19592680

Variation tolerance for ZP2 Gene

Residual Variation Intolerance Score: 23.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.02; 80.13% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ZP2 Gene

Disorders for ZP2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for ZP2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
infertility
acheiropody
  • acheiropodia
- elite association - COSMIC cancer census association via MalaCards
Search ZP2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for ZP2

Genetic Association Database (GAD)
ZP2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZP2
genes like me logo Genes that share disorders with ZP2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZP2 Gene

Publications for ZP2 Gene

  1. Conservation of mammalian secondary sperm receptor genes enables the promoter of the human gene to function in mouse oocytes. (PMID: 8385033) Liang L.-F. … Dean J. (Dev. Biol. 1993) 2 3 4 23 67
  2. Detection of zona pellucida proteins during human folliculogenesis. (PMID: 18033806) Gook D.A. … Martic M. (Hum. Reprod. 2008) 3 23
  3. Biological effects of recombinant human zona pellucida proteins on sperm function. (PMID: 16407501) Caballero-Campo P. … Gerton G.L. (Biol. Reprod. 2006) 3 23
  4. Binding of recombinant human proacrosin/acrosin to zona pellucida (ZP) glycoproteins. I. Studies with recombinant human ZPA, ZPB, and ZPC. (PMID: 15950651) Furlong L.I. … Vazquez-Levin M.H. (Fertil. Steril. 2005) 3 23
  5. Localization and functional importance of a conserved zona pellucida 2 protein domain in the human and bovine ovary using monoclonal anti-ZP2 peptide antibodies. (PMID: 14511786) Hinsch E. … Hinsch K.D. (Theriogenology 2003) 3 23

Products for ZP2 Gene

Sources for ZP2 Gene

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