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Aliases for ZP2 Gene

Aliases for ZP2 Gene

  • Zona Pellucida Glycoprotein 2 (Sperm Receptor) 2 3
  • Zona Pellucida Protein A 3 4
  • Zp-2 3 4
  • ZPA 3 4
  • Zona Pellucida Sperm-Binding Protein 2 3
  • Zona Pellucida Glycoprotein ZP2 3
  • Zona Pellucida Glycoprotein 2 4

External Ids for ZP2 Gene

Previous GeneCards Identifiers for ZP2 Gene

  • GC16M020617
  • GC16M021217
  • GC16M021175
  • GC16M021116
  • GC16M019743
  • GC16M021208

Summaries for ZP2 Gene

Entrez Gene Summary for ZP2 Gene

  • The zona pellucida is an extracellular matrix that surrounds the oocyte and early embryo. It is composed of three glycoproteins with various functions during fertilization and preimplantation development. The glycosylated mature peptide is one of the structural components of the zona pellucida and functions in secondary binding and penetration of acrosome-reacted spermatozoa. Female mice lacking this gene do not form a stable zona matrix and are sterile. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]

GeneCards Summary for ZP2 Gene

ZP2 (Zona Pellucida Glycoprotein 2 (Sperm Receptor)) is a Protein Coding gene. Diseases associated with ZP2 include acheiropody and oophoritis. Among its related pathways are Ovarian Infertility Genes and Reproduction. GO annotations related to this gene include coreceptor activity and acrosin binding. An important paralog of this gene is ZP4.

UniProtKB/Swiss-Prot for ZP2 Gene

  • The mammalian zona pellucida, which mediates species-specific sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP2 may act as a secondary sperm receptor

Gene Wiki entry for ZP2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZP2 Gene

Genomics for ZP2 Gene

Genomic Location for ZP2 Gene

21,197,450 bp from pter
21,214,510 bp from pter
17,061 bases
Minus strand

Genomic View for ZP2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZP2 Gene

No data available for Regulatory Elements for ZP2 Gene

Proteins for ZP2 Gene

  • Protein details for ZP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zona pellucida sperm-binding protein 2
    Protein Accession:
    Secondary Accessions:
    • B2R7J2
    • Q4VAN9
    • Q4VAP0
    • Q4VAP1

    Protein attributes for ZP2 Gene

    745 amino acids
    Molecular mass:
    82357 Da
    Quaternary structure:
    • Polymers of ZP2 and ZP3 organized into long filaments cross-linked by ZP1 homodimers.

    Alternative splice isoforms for ZP2 Gene


neXtProt entry for ZP2 Gene

Proteomics data for ZP2 Gene at MOPED

Post-translational modifications for ZP2 Gene

  • Contains disulfide bond(s).
  • N-glycosylated.
  • O-glycosylated; contains sulfate-substituted glycans.
  • Proteolytically cleaved before the transmembrane segment to yield the secreted ectodomain incorporated in the zona pellucida
  • Proteolytically cleaved in the N-terminal part probably by the metalloendopeptidase ASTL exocytosed from cortical granules after fertilization, yielding a N-terminal peptide of about 30 kDa which remains covalently attached to the C-terminal peptide via disulfide bond(s). This cleavage may play an important role in the post-fertilization block to polyspermy. Additional proteolytically cleavage of the N-terminal peptide of 30 kDa occurs in one-cell and two-cell embryos (By similarity).
  • Glycosylation at Asn87, Asn105, Asn122, Asn223, Asn269, Asn400, and Thr462
  • Modification sites at PhosphoSitePlus

Other Protein References for ZP2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for ZP2 Gene

Domains for ZP2 Gene

Gene Families for ZP2 Gene

  • ZP :Zona pellucida glycoproteins

Protein Domains for ZP2 Gene


Suggested Antigen Peptide Sequences for ZP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q05996
  • The ZP domain is involved in the polymerization of the ZP proteins to form the zona pellucida
  • Belongs to the ZP domain family. ZPA subfamily.
  • Contains 1 ZP domain.
genes like me logo Genes that share domains with ZP2: view

Function for ZP2 Gene

Molecular function for ZP2 Gene

GENATLAS Biochemistry: zona pellucida glycoprotein 2 (sperm receptor)
UniProtKB/Swiss-Prot Function: The mammalian zona pellucida, which mediates species-specific sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP2 may act as a secondary sperm receptor

Gene Ontology (GO) - Molecular Function for ZP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0015026 coreceptor activity TAS 8385033
GO:0032190 acrosin binding IPI 15950651
genes like me logo Genes that share ontologies with ZP2: view
genes like me logo Genes that share phenotypes with ZP2: view

Animal Models for ZP2 Gene

MGI Knock Outs for ZP2:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZP2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for ZP2 Gene

Localization for ZP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZP2 Gene

Processed zona pellucida sperm-binding protein 2: Secreted, extracellular space, extracellular matrix. Note=The glycoproteinaceous translucent extracellular matrix that surrounds the mammalian oocyte is called zona pellucida.
Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for ZP2 Gene COMPARTMENTS Subcellular localization image for ZP2 gene
Compartment Confidence
extracellular 5
plasma membrane 5
endoplasmic reticulum 4
endosome 4
golgi apparatus 4
nucleus 2
cytosol 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for ZP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005578 proteinaceous extracellular matrix IEA --
GO:0005771 multivesicular body ISS --
GO:0005783 endoplasmic reticulum ISS --
GO:0005794 Golgi apparatus ISS --
genes like me logo Genes that share ontologies with ZP2: view

Pathways for ZP2 Gene

genes like me logo Genes that share pathways with ZP2: view

Pathways by source for ZP2 Gene

1 BioSystems pathway for ZP2 Gene

Interacting Proteins for ZP2 Gene

Selected Interacting proteins: Q05996-ZP2_HUMAN for ZP2 Gene via MINT I2D

Gene Ontology (GO) - Biological Process for ZP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006828 NOT manganese ion transport ISS --
GO:0006886 intracellular protein transport ISS --
GO:0007165 signal transduction TAS 8385033
GO:0007338 single fertilization TAS --
GO:0007339 binding of sperm to zona pellucida TAS --
genes like me logo Genes that share ontologies with ZP2: view

Transcripts for ZP2 Gene

mRNA/cDNA for ZP2 Gene

(9) Additional mRNA sequences :
(3) REFSEQ mRNAs :
(3) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZP2 Gene

Zona pellucida glycoprotein 2 (sperm receptor):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZP2

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for ZP2
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZP2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19
SP1: -
SP2: - -

Relevant External Links for ZP2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZP2 Gene

mRNA expression in normal human tissues for ZP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ZP2 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (25.9) and Brain - Cerebellum (25.7).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for ZP2 Gene

SOURCE GeneReport for Unigene cluster for ZP2 Gene Hs.73982

mRNA Expression by UniProt/SwissProt for ZP2 Gene

Tissue specificity: Oocytes
genes like me logo Genes that share expressions with ZP2: view

In Situ Assay Products

Orthologs for ZP2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZP2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZP2 35
  • 99.51 (n)
  • 99.33 (a)
ZP2 36
  • 99 (a)
(Bos Taurus)
Mammalia ZP2 35
  • 80.62 (n)
  • 70.22 (a)
ZP2 36
  • 70 (a)
(Canis familiaris)
Mammalia ZP2 35
  • 80.17 (n)
  • 70.46 (a)
ZP2 36
  • 70 (a)
(Mus musculus)
Mammalia Zp2 35
  • 72.71 (n)
  • 61.04 (a)
Zp2 16
Zp2 36
  • 60 (a)
(Monodelphis domestica)
Mammalia ZP2 36
  • 49 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 50 (a)
-- 36
  • 44 (a)
(Rattus norvegicus)
Mammalia Zp2 35
  • 73.06 (n)
  • 60.9 (a)
(Gallus gallus)
Aves ZP2 35
  • 56.51 (n)
  • 44.81 (a)
ZP2 36
  • 41 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 47 (a)
-- 36
  • 48 (a)
African clawed frog
(Xenopus laevis)
Amphibia xlZPA 35
tropical clawed frog
(Silurana tropicalis)
Amphibia zp2 35
  • 50.25 (n)
  • 41.6 (a)
(Danio rerio)
Actinopterygii si:ch211-223m11.2 36
  • 14 (a)
Species with no ortholog for ZP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZP2 Gene

Gene Tree for ZP2 (if available)
Gene Tree for ZP2 (if available)

Paralogs for ZP2 Gene

Paralogs for ZP2 Gene

Selected SIMAP similar genes for ZP2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ZP2: view

Variants for ZP2 Gene

Sequence variations from dbSNP and Humsavar for ZP2 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs2066755 -- 21,211,448(-) TGGTA(C/G)CTTTG intron-variant
rs2072620 -- 21,204,712(+) CAATC(C/T)ATTTG intron-variant
rs2075518 -- 21,206,625(+) CAGTA(A/G)ATTCT intron-variant
rs2075519 -- 21,211,275(+) CTCTG(A/C)TAAGA intron-variant
rs2075520 - 21,211,351(+) AGTTC(A/C)CTGAA reference, missense

Structural Variations from Database of Genomic Variants (DGV) for ZP2 Gene

Variant ID Type Subtype PubMed ID
nsv436835 CNV Insertion 17901297
nsv833166 CNV Gain+Loss 17160897
nsv509605 CNV Insertion 20534489
nsv1762 CNV Insertion 18451855
nsv905576 CNV Gain 21882294
nsv524978 CNV Loss 19592680

Relevant External Links for ZP2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZP2 Gene

Disorders for ZP2 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for ZP2 Gene including...

Search for ZP2 Gene in MalaCards »

(4) University of Copenhagen DISEASES for ZP2 Gene

Relevant External Links for ZP2

Genetic Association Database (GAD)
genes like me logo Genes that share disorders with ZP2: view

No data available for UniProtKB/Swiss-Prot for ZP2 Gene

Publications for ZP2 Gene

  1. Conservation of mammalian secondary sperm receptor genes enables the promoter of the human gene to function in mouse oocytes. (PMID: 8385033) Liang L.-F. … Dean J. (Dev. Biol. 1993) 2 3 4 23
  2. Expression of recombinant human zona pellucida protein 2 and its binding capacity to spermatozoa. (PMID: 10570015) Tsubamoto H. … Koyama K. (Biol. Reprod. 1999) 3 23
  3. Localization and functional importance of a conserved zona pellucida 2 protein domain in the human and bovine ovary using monoclonal anti-ZP2 peptide antibodies. (PMID: 14511786) Hinsch E. … Hinsch K.D. (Theriogenology 2003) 3 23
  4. Proteolytic processing of human zona pellucida proteins. (PMID: 11804956) Kiefer S.M. … Saling P. (Biol. Reprod. 2002) 3 23
  5. Binding of recombinant human proacrosin/acrosin to zona pellucida (ZP) glycoproteins. I. Studies with recombinant human ZPA, ZPB, and ZPC. (PMID: 15950651) Furlong L.I. … Vazquez-Levin M.H. (Fertil. Steril. 2005) 3 23

Products for ZP2 Gene

Sources for ZP2 Gene

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