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Aliases for ZP2 Gene

Aliases for ZP2 Gene

  • Zona Pellucida Glycoprotein 2 2 3 4 5
  • Zona Pellucida Glycoprotein 2 (Sperm Receptor) 2 3
  • Zona Pellucida Protein A 3 4
  • Zp-2 3 4
  • ZPA 3 4
  • Zona Pellucida Sperm-Binding Protein 2 3
  • Zona Pellucida Glycoprotein ZP2 3

External Ids for ZP2 Gene

Previous GeneCards Identifiers for ZP2 Gene

  • GC16M020617
  • GC16M021217
  • GC16M021175
  • GC16M021116
  • GC16M019743
  • GC16M021208

Summaries for ZP2 Gene

Entrez Gene Summary for ZP2 Gene

  • The zona pellucida is an extracellular matrix that surrounds the oocyte and early embryo. It is composed of three glycoproteins with various functions during fertilization and preimplantation development. The glycosylated mature peptide is one of the structural components of the zona pellucida and functions in secondary binding and penetration of acrosome-reacted spermatozoa. Female mice lacking this gene do not form a stable zona matrix and are sterile. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]

GeneCards Summary for ZP2 Gene

ZP2 (Zona Pellucida Glycoprotein 2) is a Protein Coding gene. Diseases associated with ZP2 include Infertility and Acheiropody. Among its related pathways are Fertilization and Ovarian Infertility Genes. GO annotations related to this gene include coreceptor activity and acrosin binding. An important paralog of this gene is ZP4.

UniProtKB/Swiss-Prot for ZP2 Gene

  • The mammalian zona pellucida, which mediates species-specific sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP2 may act as a secondary sperm receptor.

Gene Wiki entry for ZP2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZP2 Gene

Genomics for ZP2 Gene

Regulatory Elements for ZP2 Gene

Enhancers for ZP2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16G021260 1.3 Ensembl ENCODE 10.4 -47.0 -47010 1.9 HNRNPUL1 PKNOX1 FOXA2 MLX ARNT ARID4B DMAP1 YY1 SLC30A9 ZNF766 CRYM ANKS4B TMEM159 DNAH3 ZP2 LOC105371124 LOC105371125
GH16G021263 1.2 Ensembl ENCODE 10.4 -49.8 -49839 1.7 HDAC1 ELF3 PKNOX1 ARID4B DMAP1 RAD21 THRB ZNF48 RARA IKZF2 CRYM ANKS4B DNAH3 TMEM159 ZP2 LOC105371124 LOC105371125
GH16G021202 0.6 ENCODE 0.4 +10.9 10941 2.3 RFX1 RNF2 ETV1 HLF CEBPB CEBPG PBX2 HMBOX1 HNF4A DNAH3 TMEM159 ENSG00000262983 ZP2
GH16G021198 0.2 ENCODE 0.4 +14.7 14669 2.1 DNAH3 TMEM159 ENSG00000262983 ZP2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZP2 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZP2 Gene

Chromosome:
16
Start:
21,197,450 bp from pter
End:
21,214,510 bp from pter
Size:
17,061 bases
Orientation:
Minus strand

Genomic View for ZP2 Gene

Genes around ZP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZP2 Gene

Proteins for ZP2 Gene

  • Protein details for ZP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q05996-ZP2_HUMAN
    Recommended name:
    Zona pellucida sperm-binding protein 2
    Protein Accession:
    Q05996
    Secondary Accessions:
    • B2R7J2
    • Q4VAN9
    • Q4VAP0
    • Q4VAP1

    Protein attributes for ZP2 Gene

    Size:
    745 amino acids
    Molecular mass:
    82357 Da
    Quaternary structure:
    • Can form homopolymers that assemble into long fibers (in vitro). Polymers of ZP2 and ZP3 organized into long filaments cross-linked by ZP1 homodimers.

    Alternative splice isoforms for ZP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZP2 Gene

Post-translational modifications for ZP2 Gene

  • N-glycosylated.
  • O-glycosylated; contains sulfate-substituted glycans.
  • Proteolytically cleaved before the transmembrane segment to yield the secreted ectodomain incorporated in the zona pellucida.
  • Proteolytically cleaved in the N-terminal part by the metalloendopeptidase ASTL exocytosed from cortical granules after fertilization, yielding a N-terminal peptide of about 30 kDa which remains covalently attached to the C-terminal peptide via disulfide bond(s). This cleavage may play an important role in the post-fertilization block to polyspermy. Additional proteolytically cleavage of the N-terminal peptide of 30 kDa occurs in one-cell and two-cell embryos.
  • Glycosylation at isoforms=287, isoforms=2105, posLast=122122, posLast=223223, posLast=269269, posLast=400400, and isoforms=462
  • Modification sites at PhosphoSitePlus

Other Protein References for ZP2 Gene

No data available for DME Specific Peptides for ZP2 Gene

Domains & Families for ZP2 Gene

Gene Families for ZP2 Gene

Protein Domains for ZP2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for ZP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q05996

UniProtKB/Swiss-Prot:

ZP2_HUMAN :
  • The ZP domain is involved in the polymerization of the ZP proteins to form the zona pellucida.
Domain:
  • The ZP domain is involved in the polymerization of the ZP proteins to form the zona pellucida.
  • Belongs to the ZP domain family. ZPA subfamily.
genes like me logo Genes that share domains with ZP2: view

Function for ZP2 Gene

Molecular function for ZP2 Gene

GENATLAS Biochemistry:
zona pellucida glycoprotein 2 (sperm receptor)
UniProtKB/Swiss-Prot Function:
The mammalian zona pellucida, which mediates species-specific sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP2 may act as a secondary sperm receptor.

Gene Ontology (GO) - Molecular Function for ZP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015026 coreceptor activity TAS 8385033
GO:0032190 acrosin binding IPI 15950651
genes like me logo Genes that share ontologies with ZP2: view
genes like me logo Genes that share phenotypes with ZP2: view

Animal Models for ZP2 Gene

MGI Knock Outs for ZP2:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ZP2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for ZP2 Gene

Localization for ZP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZP2 Gene

Processed zona pellucida sperm-binding protein 2: Secreted, extracellular space, extracellular matrix. Note=The glycoproteinaceous translucent extracellular matrix that surrounds the mammalian oocyte is called zona pellucida. {ECO:0000250 UniProtKB:P20239}.
Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZP2 gene
Compartment Confidence
plasma membrane 5
extracellular 5
endoplasmic reticulum 5
endosome 4
nucleus 2
golgi apparatus 2
mitochondrion 1
cytosol 1

Gene Ontology (GO) - Cellular Components for ZP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005578 proteinaceous extracellular matrix IEA --
GO:0005771 multivesicular body ISS,IEA --
GO:0005783 endoplasmic reticulum ISS,IEA --
GO:0005794 colocalizes_with Golgi apparatus IEA,ISS --
genes like me logo Genes that share ontologies with ZP2: view

Pathways & Interactions for ZP2 Gene

genes like me logo Genes that share pathways with ZP2: view

Pathways by source for ZP2 Gene

1 BioSystems pathway for ZP2 Gene

Interacting Proteins for ZP2 Gene

Gene Ontology (GO) - Biological Process for ZP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006828 NOT manganese ion transport ISS --
GO:0006886 intracellular protein transport IEA --
GO:0007165 signal transduction IEA --
GO:0007338 single fertilization IEA --
GO:0007339 binding of sperm to zona pellucida TAS --
genes like me logo Genes that share ontologies with ZP2: view

No data available for SIGNOR curated interactions for ZP2 Gene

Drugs & Compounds for ZP2 Gene

No Compound Related Data Available

Transcripts for ZP2 Gene

mRNA/cDNA for ZP2 Gene

(3) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZP2 Gene

Zona pellucida glycoprotein 2 (sperm receptor):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ZP2

Alternative Splicing Database (ASD) splice patterns (SP) for ZP2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19
SP1: -
SP2: - -
SP3:

Relevant External Links for ZP2 Gene

GeneLoc Exon Structure for
ZP2
ECgene alternative splicing isoforms for
ZP2

Expression for ZP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ZP2 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x25.9) and Brain - Cerebellum (x25.7).

Protein differential expression in normal tissues from HIPED for ZP2 Gene

This gene is overexpressed in Monocytes (32.7), Tlymphocyte (16.7), and Blymphocyte (15.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZP2 Gene



Protein tissue co-expression partners for ZP2 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZP2 Gene:

ZP2

SOURCE GeneReport for Unigene cluster for ZP2 Gene:

Hs.73982

Evidence on tissue expression from TISSUES for ZP2 Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with ZP2: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZP2 Gene

Orthologs for ZP2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZP2 34 35
  • 99.51 (n)
cow
(Bos Taurus)
Mammalia ZP2 34 35
  • 80.62 (n)
dog
(Canis familiaris)
Mammalia ZP2 34 35
  • 80.17 (n)
rat
(Rattus norvegicus)
Mammalia Zp2 34
  • 73.06 (n)
mouse
(Mus musculus)
Mammalia Zp2 34 16 35
  • 72.71 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 50 (a)
OneToMany
-- 35
  • 44 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia ZP2 35
  • 49 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZP2 34 35
  • 56.51 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 48 (a)
OneToMany
-- 35
  • 47 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia zp2 34
  • 50.25 (n)
African clawed frog
(Xenopus laevis)
Amphibia xlZPA 34
zebrafish
(Danio rerio)
Actinopterygii si:ch211-223m11.2 35
  • 14 (a)
ManyToMany
Species where no ortholog for ZP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZP2 Gene

ENSEMBL:
Gene Tree for ZP2 (if available)
TreeFam:
Gene Tree for ZP2 (if available)

Paralogs for ZP2 Gene

Paralogs for ZP2 Gene

(2) SIMAP similar genes for ZP2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ZP2: view

Variants for ZP2 Gene

Sequence variations from dbSNP and Humsavar for ZP2 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1000253199 -- 21,202,818(+) GGGGT(-/ACTTAA)ACTTA intron-variant
rs1000321457 -- 21,197,766(+) CTTAC(C/T)TCGTG nc-transcript-variant, reference, missense
rs1000549578 -- 21,208,394(+) TTAGG(A/G)GACCA intron-variant
rs1001368370 -- 21,201,207(+) CAAAA(-/C)AAAAA intron-variant
rs1001461454 -- 21,207,758(+) GACAT(A/G)GGGTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZP2 Gene

Variant ID Type Subtype PubMed ID
esv3638164 CNV gain 21293372
esv3638165 CNV gain 21293372
nsv1762 CNV insertion 18451855
nsv436835 CNV insertion 17901297
nsv509605 CNV insertion 20534489
nsv524978 CNV loss 19592680
nsv571623 CNV gain 21841781
nsv833166 CNV gain+loss 17160897

Variation tolerance for ZP2 Gene

Residual Variation Intolerance Score: 23.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.02; 80.13% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZP2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZP2 Gene

Disorders for ZP2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for ZP2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
infertility
acheiropody
  • acheiropodia
- elite association - COSMIC cancer census association via MalaCards
Search ZP2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for ZP2

Genetic Association Database (GAD)
ZP2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZP2
genes like me logo Genes that share disorders with ZP2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZP2 Gene

Publications for ZP2 Gene

  1. Conservation of mammalian secondary sperm receptor genes enables the promoter of the human gene to function in mouse oocytes. (PMID: 8385033) Liang L.-F. … Dean J. (Dev. Biol. 1993) 2 3 4 22 64
  2. Detection of zona pellucida proteins during human folliculogenesis. (PMID: 18033806) Gook D.A. … Martic M. (Hum. Reprod. 2008) 3 22 64
  3. Biological effects of recombinant human zona pellucida proteins on sperm function. (PMID: 16407501) Caballero-Campo P. … Gerton G.L. (Biol. Reprod. 2006) 3 22 64
  4. Binding of recombinant human proacrosin/acrosin to zona pellucida (ZP) glycoproteins. I. Studies with recombinant human ZPA, ZPB, and ZPC. (PMID: 15950651) Furlong L.I. … Vazquez-Levin M.H. (Fertil. Steril. 2005) 3 22 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for ZP2 Gene

Sources for ZP2 Gene

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