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ZP2 Gene

protein-coding   GIFtS: 51

GC16M021116
zona pellucida glycoprotein 2 (sperm receptor)
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
ZPA 2, 3
Descriptions
Zona pellucida glycoprotein ZP2 3
Zona pellucida protein A 2, 3
zona pellucida glycoprotein 2 2
zona pellucida glycoprotein 2 (sperm receptor) 2
zona pellucida sperm-binding protein 2 2
External Ids
HGNC: 131881
Entrez Gene: 77832
UniProtKB: Q059963
Ensembl: ENSG000001033107
Search outside databases for aliases for ZP2 gene

Previous GC identifers: GC16M020617 GC16M021217 GC16M021175

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for ZP2:
The zona pellucida is an extracellular matrix that surrounds the oocyte and early embryo. It is
composed primarily of three or four glycoproteins with various functions during fertilization and
preimplantation development. The protein encoded by this gene is a structural component of the
zona pellucida and functions in secondary binding and penetration of acrosome-reacted spermatozoa.
The nascent protein contains a N-terminal signal peptide sequence, a conserved ZP domain, a
consensus furin cleavage site, and a C-terminal transmembrane domain. It is hypothesized that
furin cleavage results in release of the mature protein from the plasma membrane for subsequent
incorporation into the zona pellucida matrix. However, the requirement for furin cleavage in this
process remains controversial based on mouse studies. [provided by RefSeq]

UniProtKB/Swiss-Prot: ZP2_HUMAN, Q05996
Function: The mammalian zona pellucida, which mediates species-specific sperm binding, induction of
the acrosome reaction and prevents post-fertilization polyspermy, is composed of three to four
glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP2 may act as a secondary sperm receptor

Gene Wiki entry for ZP2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p12   Ensembl cytogenetic band:  16p12.2   HGNC cytogenetic band: 16p12

ZP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M021116:     (about GC identifiers)

Start:
21,116,274 bp from pter
End:
21,130,369 bp from pter
Size:
14,096 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000016.8  NT_010393.15  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: ZP2_HUMAN, Q05996 (See protein sequence)
Recommended Name: Zona pellucida sperm-binding protein 2 precursor  
Size: 745 amino acids; 82357 Da
Subunit: Polymers of ZP2 and ZP3 organized into long filaments cross-linked by ZP1 homodimers (By
similarity)
Subcellular location: Processed zona pellucida sperm-binding protein 2: Secreted, extracellular
space, extracellular matrix
Subcellular location: Cell membrane; Single-pass type I membrane protein
Developmental stage: Expressed during the 2-week growth phase of oogenesis, prior to ovulation
Secondary accessions: Q4VAN9 Q4VAP0

Post-translational modifications:

  • Proteolytically cleaved before the transmembrane segment to yield the secreted ectodomain
    incorporated in the zona pellucida1
  • Proteolytically cleaved in the N-terminal part after fertilization, yielding a N-terminal peptide
    of about 30 kDa which remains covalently attached to the C-terminal peptide via disulfide bond(s).
    This cleavage may play an important role in the post-fertilization block to polyspermy (By
    similarity)1
  • O-glycosylated; contains sulfate-substituted glycans (By similarity)1


  • REFSEQ proteins: NP_003451.1  

    ENSEMBL proteins: 
    ENSP00000219593 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
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    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse Abcam for Recombinant Proteins
    Human Recombinant Proteins from Abnova (ZP2)
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    4 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576 extracellular region IEA--
    GO:0005578 proteinaceous extracellular matrix IEA--
    GO:0005886 plasma membrane IEA--
    GO:0016021 integral to membrane IEA--
    About this table

    Antibodies for ZP2: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for ZP2
    Browse R&D Systems for Antibodies
    Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
    Monoclonal and Polyclonal Antibodies from Abnova (ZP2)
    Novus Biologicals Antibody for ZP2

    Assays for ZP2: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    3 InterPro domains/families:
     IPR017977 Endoglin/CD105_CS
     IPR017976 Endoglin/CD105_subgr
     IPR001507 Endoglin/CD105


       GeneDecks  ZP2 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry Q05996

    ProtoNet protein and cluster: Q05996

    1 Blocks protein family: IPB001507 Endoglin/CD105 antigen

    UniProtKB/Swiss-Prot: ZP2_HUMAN, Q05996
    Domain: The ZP domain is involved in the polymerization of the ZP proteins to form the zona
    pellucida
    Similarity: Belongs to the ZP domain family. ZPA subfamily
    Similarity: Contains 1 ZP domain

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (ZP2)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (ZP2)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_003460

                  Applied Biosystems Silencer® siRNAs for ZP2

                  Sigma-Aldrich siRNA and siRNA Panels for ZP2  
                         Sigma-Aldrich shRNA Panels and shRNA for ZP2  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for ZP2
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_003460
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_003460
                                     untagged cDNA clone in CMV expression vector: NM_003460 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_003460

    UniProtKB/Swiss-Prot: ZP2_HUMAN, Q05996
    Function: The mammalian zona pellucida, which mediates species-specific sperm binding, induction of
    the acrosome reaction and prevents post-fertilization polyspermy, is composed of three to four
    glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP2 may act as a secondary sperm receptor

    Genatlas biochemistry entry for ZP2:
    zona pellucida glycoprotein 2 (sperm receptor)

    3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Zp2):

    embryogenesisendocrine/exocrine glandreproductive system

    3 Gene Ontology (GO) molecular function terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515 protein binding IPI17474147
    GO:0015026 coreceptor activity TAS8385033
    GO:0032190 acrosin binding IPI15950651
    About this table

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


     Gene Network CentralTM Interacting Genes and Proteins Network for  ZP2 


    5/18 Interacting proteins for ZP2 (ENSP000002195933 Q059961) via UniProtKB, MINT, and/or STRING (see all 18 )
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PLCG1P191741EBI-1755919, EBI-79387
    SRCP129311EBI-1755919, EBI-621482
    ZPBPENSP000000460873STRING (score=.972)
    FIGLAENSP000003330973STRING (score=.946)
    HOXB8ENSP000002391443STRING (score=.946)
    About this table

    2 Gene Ontology (GO) biological process terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007338 single fertilization IEA--
    GO:0007339 binding of sperm to zona pellucida TAS8385033
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for ZP2

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (ZP2)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (ZP2)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_003460

                  Sigma-Aldrich siRNA and siRNA Panels for ZP2  
                         Sigma-Aldrich shRNA Panels and shRNA for ZP2  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_003460  

    REFSEQ mRNAs for ZP2 gene: 

    NM_003460.1   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_003460  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_003460
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_003460
                                     untagged cDNA clone in CMV expression vector: NM_003460 

    Additional cDNA sequence: 

    AK293805.1 AK308820.1 AK310454.1 AK313003.1 BC096304.3 BC096305.3 BC096306.1 BC096307.3 
    M90366.1 

    2 DOTS entries:

    DT.92414863  DT.120686481 

    3 AceView cDNA sequences:

    M90366 NM_003460 AW753370 

    highest scoring ESTs for ZP2:

    M90366 BC096304 BC096305 BC096306 BC096307 NM_003460 DA089667 DN992639 AW753370 DA073634 

    Unigene Cluster for ZP2:

    Zona pellucida glycoprotein 2 (sperm receptor)
    Hs.73982  [show with all ESTs]
    Unigene Representative Sequence: AK310454


    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for ZP2

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19
    SP1:                    -                                                                                                         
    SP2:                    -                                                           -                                             
    SP3:                                                                                                                              

    About this scheme

    ECgene alternative splicing isoforms for ZP2

    1 Ensembl transcript including schematic representation:
    ENST00000219593  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    ZP2 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for ZP2

    1 / 2 / 3

    3 probe-sets matching ZP2 gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

    32431_at2, 3 U95-A 2 1.00 0.97 1.00 1.00 M90366 1.00 1.00 1.00 1

    207933_at2, 3 U133-A 1 1.00 1.00 -- -- NM_003460 0.60 1.00 0.82 1

    207933_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    About this table
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: --

    SOURCE GeneReport for Unigene cluster: Hs.73982

    Expression variation in blood from EXPOLDB for ZP2

    UniProtKB/Swiss-Prot: ZP2_HUMAN, Q05996
    Tissue specificity: Oocytes

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for ZP2 gene from 5/6 species (see all 6 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    ZP21   -- zona pellucida glycoprotein 2 (sperm receptor) 79.94(n)
    70.27(a)
    403988  NM_001003304.1  NP_001003304.1 
    chimpanzee
    (Pan troglodytes)
    ZP21   -- zona pellucida glycoprotein 2 (sperm receptor) 99.49(n)
    99.3(a)
    453979  XM_510869.2  XP_510869.2 
    cow
    (Bos taurus)
    ZP21   -- zona pellucida glycoprotein 2 (sperm receptor) 80.62(n)
    70.22(a)
    280963  NM_173973.2  NP_776398.1 
    mouse
    (Mus musculus)
    Zp21, 5 7 (56.00 cM)5
    zona pellucida glycoprotein 21, 5 73.12(n)1
    61.41(a)1
    227871  NM_011775.51  NP_035905.11 
     AK1359035  AK1386995  (see all 9)
    chicken
    (Gallus gallus)
    ZP21   -- zona pellucida glycoprotein 2 (sperm receptor) 56.51(n)
    44.81(a)
    427006  NM_001039098.1  NP_001034187.1 
    About this table        Species with no ortholog for ZP2

    ENSEMBL Gene Tree for ZP2
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for ZP2 gene
    ZP42  ZP12  

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/88 NCBI SNPs in ZP2 are shown (see all 88 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 48)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 16 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs37599851,2
    A,C,F,H21131281(+) AAACAC/TCACAC 1 -- ng314Minor allele frequency- T:0.35EU EA WA 420
    rs20755201,2
    C,F,H,O21130173(+) AGTTCA/CCTGAA 1 G/V mis1 ese319Minor allele frequency- N:0.00NA EA EU WA 1706
    rs37599841,2
    A,C,F,H21131155(+) CCCAAG/CTGTAA 1 -- ng318Minor allele frequency- C:0.30EU EA WA 838
    rs20755211,2
    A,C,F,H21130442(+) AGCCGC/AATCCA 1 -- ng3110Minor allele frequency- A:0.45EU EA WA NA 980
    rs118598541,2
    H21131825(+) TAttaG/Tgctgg 1 -- ng314Minor allele frequency- T:0.00EU EA WA 418
    --
    rs80530981,2
    H21130940(+) agattG/Aggttt 1 -- ng314Minor allele frequency- A:0.00EU EA WA 416
    rs20755261,2
    A,C,F,H21123173(+) TGTCCA/GGGAGA 1 P/P syn1 ese315Minor allele frequency- G:0.33MN EA NA EU WA 1288
    rs169712341,2
    C,F,H21124562(+) CTGTCG/ATCAGC 1 D/D syn1 ese312Minor allele frequency- A:0.29NA EU EA WA 1010
    rs20726201,2
    A,C,F,H21123534(+) CAATCC/TATTTG 1 -- int116Minor allele frequency- T:0.33NS EU EA WA NA 1032
    rs110744891,2
    A,C,F,H21118779(+) AGTCAT/CACGTA 1 -- int111Minor allele frequency- C:0.45EU EA WA NA 982
    About this table

    HapMap Linkage Disequilibrium images for ZP2 (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    OMIM: 182888

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10/54 PubMed articles for ZP2 gene (see all 54 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 7783 HGNC: 13188 AceView: ZP2 Ensembl:ENSG00000103310 euGenes: HUgn7783
    ECgene: ZP2 H-InvDB: ZP2
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

      --
    (Available from WIS Yeda, Salk, Tufts)
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      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for ZP2:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



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     Predesigned and custom siRNAs for ZP2 Antibodies for ZP2
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     Lentivirus-delivered shRNAs for ZP2 Browse small molecules at Sigma-Aldrich
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     Antibodies for ZP2

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