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Aliases & Descriptions for ZP2
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| | | Descriptions |
|---|
| Zona pellucida glycoprotein ZP2 3 | | Zona pellucida protein A 2, 3 | | zona pellucida glycoprotein 2 2 | | zona pellucida glycoprotein 2 (sperm receptor) 2 | | zona pellucida sperm-binding protein 2 2 |
|
| | Search outside databases for aliases for ZP2 genePrevious GC identifers: GC16M020617 GC16M021217 GC16M021175 |
Summaries for ZP2(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for ZP2: The zona pellucida is an extracellular matrix that surrounds the oocyte and early embryo. It is composed primarily of three or four glycoproteins with various functions during fertilization and preimplantation development. The protein encoded by this gene is a structural component of the zona pellucida and functions in secondary binding and penetration of acrosome-reacted spermatozoa. The nascent protein contains a N-terminal signal peptide sequence, a conserved ZP domain, a consensus furin cleavage site, and a C-terminal transmembrane domain. It is hypothesized that furin cleavage results in release of the mature protein from the plasma membrane for subsequent incorporation into the zona pellucida matrix. However, the requirement for furin cleavage in this process remains controversial based on mouse studies. [provided by RefSeq] UniProtKB/Swiss-Prot: ZP2_HUMAN, Q05996Function: The mammalian zona pellucida, which mediates species-specific sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP2 may act as a secondary sperm receptorGene Wiki entry for ZP2 |
Genomic Location for ZP2
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 16p12 Ensembl cytogenetic band: 16p12.2 HGNC cytogenetic band: 16p12ZP2 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 16 GeneLoc Exon Structure GeneLoc location for GC16M021116:
(about GC identifiers)
Start:
|
21,116,274 bp from pter |
End:
|
21,130,369 bp from pter |
Size:
|
14,096 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000016.8 NT_010393.15
| Proteins for ZP2
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: ZP2_HUMAN, Q05996 (See
protein sequence)Recommended Name: Zona pellucida sperm-binding protein 2 precursor Size: 745 amino acids; 82357 Da
Subunit: Polymers of ZP2 and ZP3 organized into long filaments cross-linked by ZP1 homodimers (By similarity)
Subcellular location: Processed zona pellucida sperm-binding protein 2: Secreted, extracellular space, extracellular matrix
Subcellular location: Cell membrane; Single-pass type I membrane protein
Developmental stage: Expressed during the 2-week growth phase of oogenesis, prior to ovulation
Secondary accessions: Q4VAN9 Q4VAP0Post-translational modifications:
Proteolytically cleaved before the transmembrane segment to yield the secreted ectodomain incorporated in the zona pellucida1
Proteolytically cleaved in the N-terminal part after fertilization, yielding a N-terminal peptide of about 30 kDa which remains covalently attached to the C-terminal peptide via disulfide bond(s). This cleavage may play an important role in the post-fertilization block to polyspermy (By similarity)1
O-glycosylated; contains sulfate-substituted glycans (By similarity)1
REFSEQ proteins: NP_003451.1
ENSEMBL proteins: ENSP00000219593
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
4 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for ZP2: Assays for ZP2: | Protein
Domains/ Families for ZP2(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q05996
ProtoNet protein and cluster: Q05996 1 Blocks protein family: IPB001507 Endoglin/CD105 antigen
UniProtKB/Swiss-Prot: ZP2_HUMAN, Q05996Domain: The ZP domain is involved in the polymerization of the ZP proteins to form the zona pellucidaSimilarity: Belongs to the ZP domain family. ZPA subfamilySimilarity: Contains 1 ZP domain | Gene Function for ZP2
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_003460
Applied Biosystems Silencer® siRNAs for ZP2
Sigma-Aldrich siRNA and siRNA Panels for ZP2  Sigma-Aldrich shRNA Panels and shRNA for ZP2  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_003460                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_003460                                  untagged cDNA clone in CMV expression vector: NM_003460 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_003460
UniProtKB/Swiss-Prot: ZP2_HUMAN, Q05996Function: The mammalian zona pellucida, which mediates species-specific sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP2 may act as a secondary sperm receptorGenatlas biochemistry entry for ZP2:zona pellucida glycoprotein 2 (sperm receptor)3 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Zp2):
3 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for ZP2
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
Gene Network CentralTM Interacting Genes and Proteins Network for ZP2 
5/18 Interacting proteins for ZP2 (ENSP000002195933 Q059961) via UniProtKB, MINT, and/or STRING (see all 18
)About this table
2 Gene Ontology (GO) biological process terms (links to tree view): About this table
|
Drugs & Compounds for ZP2(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for ZP2
|
Transcripts for ZP2(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_003460
Sigma-Aldrich siRNA and siRNA Panels for ZP2  Sigma-Aldrich shRNA Panels and shRNA for ZP2  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_003460 REFSEQ mRNAs for ZP2 gene: NM_003460.1
Applied Biosystems TaqMan ® Gene Expression Assays: NM_003460               OriGene GFP tagged cDNA clone in CMV expression vector: NM_003460                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_003460                                  untagged cDNA clone in CMV expression vector: NM_003460  Additional cDNA sequence: AK293805.1 AK308820.1 AK310454.1 AK313003.1 BC096304.3 BC096305.3 BC096306.1 BC096307.3 M90366.1 2 DOTS entries: DT.92414863 DT.120686481 3 AceView cDNA sequences:M90366 NM_003460 AW753370
highest scoring ESTs for ZP2:M90366 BC096304 BC096305 BC096306 BC096307 NM_003460 DA089667 DN992639 AW753370 DA073634 Unigene Cluster for ZP2: Zona pellucida glycoprotein 2 (sperm receptor) Hs.73982 [show with all ESTs]Unigene Representative Sequence: AK310454
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for ZP2
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | |
| SP1: | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for ZP2
1 Ensembl transcript including schematic representation: ENST00000219593
|
Expression for ZP2
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| ZP2 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for ZP2
1 / 2 / 3 3 probe-sets matching ZP2 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: --
SOURCE GeneReport for Unigene cluster: Hs.73982
Expression variation in blood from EXPOLDB for ZP2 UniProtKB/Swiss-Prot: ZP2_HUMAN, Q05996Tissue specificity: Oocytes |
Orthologs for ZP2
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for ZP2 gene from 5/6 species (see all 6
)
About this table Species with no ortholog for ZP2
ENSEMBL Gene Tree for ZP2 | Paralogs for ZP2(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for ZP2 gene
- ZP42 ZP12
|
SNPs/Variants for ZP2(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for ZP2 (up to first 250kb)
|
Disorders & Mutations for ZP2
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 182888
|
Medical News for ZP2(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for ZP2 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/54 PubMed articles for ZP2 gene (see all 54
):- Conservation of mammalian secondary sperm receptor genes enables the promoter of the human gene to function in mouse oocytes. (PubMed id 8385033)1, 2, 3, 4 Liang L.-F. and Dean J. (1993)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. (PubMed id 10493829)3, 4 Loftus B.J....Adams M.D. (1999)
- Localization and functional importance of a conserved zona pellucida 2 protein domain in the human and bovine ovary using monoclonal anti-ZP2 peptide antibodies. (PubMed id 14511786)1, 3 Hinsch E....Hinsch K.D. (2003)
- Expression of recombinant human zona pellucida protein 2 and its binding capacity to spermatozoa. (PubMed id 10570015)1, 3 Tsubamoto H....Koyama K. (1999)
- Detection of zona pellucida proteins during human folliculogenesis. (PubMed id 18033806)1, 3 Gook D.A....Martic M. (2008)
- Biological effects of recombinant human zona pellucida proteins on sperm function. (PubMed id 16407501)1, 3 Caballero-Campo P....Gerton G.L. (2006)
- Binding of recombinant human proacrosin/acrosin to zona pellucida (ZP) glycoproteins. I. Studies with recombinant human ZPA, ZPB, and ZPC. (PubMed id 15950651)1, 3 Furlong L.I....Vazquez-Levin M.H. (2005)
- Proteolytic processing of human zona pellucida proteins. (PubMed id 11804956)1, 3 Kiefer S.M. and Saling P. (2002)
- Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening. (PubMed id 17474147)3 Wu C....Li S.S. (2007)
|
Search for ZP2
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing ZP2
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing ZP2
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZP2(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for ZP2(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for ZP2:

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