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ZP2 Gene

protein-coding   GIFtS: 59
GCID: GC16M021208

Zona Pellucida Glycoprotein 2 (Sperm Receptor)

  See ZP2-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zona Pellucida Glycoprotein 2 (Sperm Receptor)1 2     Zona Pellucida Glycoprotein ZP22
Zona Pellucida Protein A2 3     Zona Pellucida Sperm-Binding Protein 22
ZPA2 3     Zona Pellucida Glycoprotein 23
Zp-22 3     

External Ids:    HGNC: 131881   Entrez Gene: 77832   Ensembl: ENSG000001033107   OMIM: 1828885   UniProtKB: Q059963   

Export aliases for ZP2 gene to outside databases

Previous GC identifers: GC16M020617 GC16M021217 GC16M021175 GC16M021116 GC16M019743


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ZP2 Gene:
The zona pellucida is an extracellular matrix that surrounds the oocyte and early embryo. It is composed of three
glycoproteins with various functions during fertilization and preimplantation development. The glycosylated
mature peptide is one of the structural components of the zona pellucida and functions in secondary binding and
penetration of acrosome-reacted spermatozoa. Female mice lacking this gene do not form a stable zona matrix and
are sterile. Alternative splicing results in multiple transcript variants. (provided by RefSeq, Feb 2014)

GeneCards Summary for ZP2 Gene:
ZP2 (zona pellucida glycoprotein 2 (sperm receptor)) is a protein-coding gene. Diseases associated with ZP2 include acheiropody, and oophoritis. GO annotations related to this gene include acrosin binding and coreceptor activity. An important paralog of this gene is ZP4.

UniProtKB/Swiss-Prot: ZP2_HUMAN, Q05996
Function: The mammalian zona pellucida, which mediates species-specific sperm binding, induction of the acrosome
reaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, ZP1, ZP2, ZP3,
and ZP4. ZP2 may act as a secondary sperm receptor

Gene Wiki entry for ZP2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000016.9  NT_187260.1  NC_018927.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for ZP2
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZP2 promoter sequence
   Search Chromatin IP Primers for ZP2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p12   Ensembl cytogenetic band:  16p12.2   HGNC cytogenetic band: 16p12

ZP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZP2 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M021208:  view genomic region     (about GC identifiers)

Start:
21,208,773 bp from pter      End:
21,225,831 bp from pter
Size:
17,059 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ZP2_HUMAN, Q05996 (See protein sequence)
Recommended Name: Zona pellucida sperm-binding protein 2 precursor  
Size: 745 amino acids; 82357 Da
Subunit: Polymers of ZP2 and ZP3 organized into long filaments cross-linked by ZP1 homodimers (By similarity)
Developmental stage: Expressed during the 2-week growth phase of oogenesis, prior to ovulation
Secondary accessions: B2R7J2 Q4VAN9 Q4VAP0

Explore the universe of human proteins at neXtProt for ZP2: NX_Q05996

Explore proteomics data for ZP2 at MOPED

Post-translational modifications: 

  • Proteolytically cleaved before the transmembrane segment to yield the secreted ectodomain incorporated in the zona
    pellucida1
  • Proteolytically cleaved in the N-terminal part probably by the metalloendopeptidase ASTL exocytosed from cortical
    granules after fertilization, yielding a N-terminal peptide of about 30 kDa which remains covalently attached to
    the C-terminal peptide via disulfide bond(s). This cleavage may play an important role in the post-fertilization
    block to polyspermy. Additional proteolytically cleavage of the N-terminal peptide of 30 kDa occurs in one-cell
    and two-cell embryos (By similarity)1
  • Contains disulfide bond(s) (By similarity)1
  • N-glycosylated (By similarity)1
  • O-glycosylated; contains sulfate-substituted glycans (By similarity)1
  • Glycosylation2 at Asn87, Asn105, Asn122, Asn223, Asn269, Asn400, Thr462
  • Modification sites at PhosphoSitePlus

  • See ZP2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001277033.1  NP_003451.1  

    ENSEMBL proteins: 
     ENSP00000458991   ENSP00000460971   ENSP00000219593  
    Reactome Protein details: Q05996

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZP: Zona pellucida glycoproteins

    2 InterPro protein domains:
     IPR017977 ZP_dom_CS
     IPR001507 ZP_dom

    Graphical View of Domain Structure for InterPro Entry Q05996

    ProtoNet protein and cluster: Q05996

    1 Blocks protein domain: IPB001507 Endoglin/CD105 antigen

    UniProtKB/Swiss-Prot: ZP2_HUMAN, Q05996
    Domain: The ZP domain is involved in the polymerization of the ZP proteins to form the zona pellucida
    Similarity: Belongs to the ZP domain family. ZPA subfamily
    Similarity: Contains 1 ZP domain


    Find genes that share domains with ZP2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZP2_HUMAN, Q05996
    Function: The mammalian zona pellucida, which mediates species-specific sperm binding, induction of the acrosome
    reaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, ZP1, ZP2, ZP3,
    and ZP4. ZP2 may act as a secondary sperm receptor

         Genatlas biochemistry entry for ZP2:
    zona pellucida glycoprotein 2 (sperm receptor)

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0015026coreceptor activity TAS8385033
    GO:0032190acrosin binding IPI15950651
         
    Find genes that share ontologies with ZP2           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for ZP2:
     Decreased G3BP1 protein expres 

         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Zp2):
     cellular  embryogenesis  endocrine/exocrine gland  reproductive system 

    Find genes that share phenotypes with ZP2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Zp2tm1Dean for ZP2

       genOway: Develop your customized and physiologically relevant rodent model for ZP2

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZP2_HUMAN, Q05996: Processed zona pellucida sperm-binding protein 2: Secreted, extracellular space,
    extracellular matrix. Note=The glycoproteinaceous translucent extracellular matrix that surrounds the mammalian
    oocyte is called zona pellucida
    ZP2_HUMAN, Q05996: Cell membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    plasma membrane5
    endoplasmic reticulum4
    endosome4
    golgi apparatus4
    nucleus2
    cytosol1
    mitochondrion1

    Gene Ontology (GO): Selected cellular component terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005578proteinaceous extracellular matrix IEA--
    GO:0005771multivesicular body ISS--
    GO:0005783endoplasmic reticulum ISS--
    GO:0005794Golgi apparatus ISS--

    Find genes that share ontologies with ZP2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ZP2 About    
    See pathways by source

    SuperPathContained pathways About
    1Reproduction
    Reproduction1.00
    Interaction With The Zona Pellucida0.00
    Fertilization1.00
    2Ovarian Infertility Genes
    Ovarian Infertility Genes


    Find genes that share SuperPaths with ZP2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for ZP2
        Ovarian Infertility Genes


    1 Reactome Pathway for ZP2
        Interaction With The Zona Pellucida


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZP2
    Interactions:

        GeneGlobe Interaction Network for ZP2

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for ZP2 (Q059962, 3 ENSP000002195934) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PLCG1P191742, 3, ENSP000002440074MINT-8113335 I2D: score=3 STRING: ENSP00000244007
    SRCP129312, 3, ENSP000003509414MINT-8113323 I2D: score=3 STRING: ENSP00000350941
    ACRP103233, ENSP000002161394I2D: score=4 STRING: ENSP00000216139
    ZPBPQ9BS863, ENSP000000460874I2D: score=1 STRING: ENSP00000046087
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006828NOT manganese ion transport ISS--
    GO:0006886intracellular protein transport ISS--
    GO:0007165signal transduction TAS8385033
    GO:0007338single fertilization TAS--
    GO:0007339binding of sperm to zona pellucida TAS--

    Find genes that share ontologies with ZP2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
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    Browse Tocris compounds for ZP2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ZP2 gene (2 alternative transcripts): 
    NM_001290104.1  NM_003460.2  

    Unigene Cluster for ZP2:

    Zona pellucida glycoprotein 2 (sperm receptor)
    Hs.73982  [show with all ESTs]
    Unigene Representative Sequence: AK310454
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000574091 ENST00000574002(uc002dii.2 uc010bwn.1) ENST00000573114
    ENST00000576162(uc010bwo.3) ENST00000572752 ENST00000219593
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    Additional mRNA sequence: 

    AK293805.1 AK308820.1 AK310454.1 AK313003.1 BC096304.3 BC096305.3 BC096306.1 BC096307.3 
    M90366.1 

    2 DOTS entries:

    DT.92414863  DT.120686481 

    3 AceView cDNA sequences:

    M90366 NM_003460 AW753370 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for ZP2    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19
    SP1:                    -                                                                                                         
    SP2:                    -                                                           -                                             
    SP3:                                                                                                                              


    ECgene alternative splicing isoforms for ZP2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZP2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ZP2 Expression
    About this image


    ZP2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Ovary (Reproductive System)    fully expand to see all 3 entries
             Secondary Oocyte Antral Follicle
             Oocytes
     
     Gonad
             Secondary Oocyte Antral Follicle
     
     Testis (Reproductive System)
             Long-time differentiated EBs
     
     NULL (Uncategorized)
             Short-term differentiated embryoid bodies
     
     Inner Cell Mass (Early Embryonic Tissues)
             ES-J1
    ZP2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZP2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.73982

    UniProtKB/Swiss-Prot: ZP2_HUMAN, Q05996
    Tissue specificity: Oocytes

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ZP2 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zp21 , 5 zona pellucida glycoprotein 21, 5 72.71(n)1
    61.04(a)1
      7 (64.38 cM)5
    227871  NM_011775.61  NP_035905.11 
     1201323615 
    chicken
    (Gallus gallus)
    Aves ZP21 zona pellucida glycoprotein 2 (sperm receptor) 56.51(n)
    44.81(a)
      427006  NM_001039098.1  NP_001034187.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    48(a)
    47(a)
    many → 1
    many → 1
    AAWZ02040743(74-6379)
    AAWZ02037074(487-15104)
    African clawed frog
    (Xenopus laevis)
    Amphibia xlZPA2 vitelline envelope 69/64 kDa glycoprotein 76.58(n)    AF038151.1 
    zebrafish
    (Danio rerio)
    Actinopterygii si:ch211-223m11.26
    si:ch211-223m11.2
    14(a)
    many ↔ many
    20(14012844-14028925) ENSDARG00000017188


    ENSEMBL Gene Tree for ZP2 (if available)
    TreeFam Gene Tree for ZP2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZP2 gene
    ZP42  ZP12  
    2 SIMAP similar genes for ZP2 using alignment to 2 protein entries:     ZP2_HUMAN (see all proteins):
    ZP4    ZP1

    Find genes that share paralogs with ZP2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZP2 (see all 489)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1141628601,2
    F--21208302(+) TTGTCT/GTTAGT 1 -- ds50011Minor allele frequency- G:0.06WA 118
    rs1817601681,2
    --21208403(+) CTTATA/GTTACT 1 -- ds50010--------
    rs1836374861,2
    --21208444(+) AAAAGA/GAGGGG 1 -- ds50010--------
    rs1880468661,2
    --21208449(+) AAGGGA/GGGTTG 1 -- ds50010--------
    rs1455220641,2
    --21208544(+) GCTATA/CGCTAA 1 -- ds50010--------
    rs1477228841,2
    --21208568(+) ACTGGG/TAGTGT 1 -- ds50010--------
    rs1174444551,2
    C,F--21208570(+) TGGGAG/ATGTCA 1 -- ds50011Minor allele frequency- A:0.05NA 120
    rs1426003131,2
    C--21208632(+) ACAATC/TATACC 1 -- ds50010--------
    rs1813020371,2
    C--21208665(+) ATATAC/TAAATC 1 -- ds50010--------
    rs1449320261,2
    C--21208745(+) AATCT-/TAATAAGA 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for ZP2 (21208773 - 21225831 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for ZP2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv1762CNV Insertion18451855
    nsv509605CNV Insertion20534489
    nsv436835CNV Insertion17901297
    nsv524978CNV Loss19592680
    nsv905576CNV Gain21882294
    nsv833166CNV Gain+Loss17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 182888    OMIM disorders: --

    2 diseases for ZP2:    
    About MalaCards
    acheiropody    oophoritis

    4 diseases from the University of Copenhagen DISEASES database for ZP2:
    Polydactyly     Oophoritis     Acheiropody     Infertility

    Find genes that share disorders with ZP2           About GenesLikeMe

    Genetic Association Database (GAD): ZP2

    Export disorders for ZP2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZP2 gene, integrated from 10 sources (see all 61):
    (articles sorted by number of sources associating them with ZP2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Conservation of mammalian secondary sperm receptor genes enables the promoter of the human gene to function in mouse oocytes. (PubMed id 8385033)1, 2, 3, 9 Liang L.-F. and Dean J. (Dev. Biol. 1993)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. (PubMed id 10493829)1, 2 Loftus B.J.... Adams M.D. (Genomics 1999)
    4. Localization and functional importance of a conserved zona pellucida 2 protein domain in the human and bovine ovary using monoclonal anti-ZP2 peptide antibodies. (PubMed id 14511786)1, 9 Hinsch E....Hinsch K.D. (Theriogenology 2003)
    5. Expression of recombinant human zona pellucida protein 2 and its binding capacity to spermatozoa. (PubMed id 10570015)1, 9 Tsubamoto H....Koyama K. (Biol. Reprod. 1999)
    6. Detection of zona pellucida proteins during human folliculogenesis. (PubMed id 18033806)1, 9 Gook D.A....Martic M. (Hum. Reprod. 2008)
    7. Biological effects of recombinant human zona pellucida proteins on sperm function. (PubMed id 16407501)1, 9 Caballero-Campo P....Gerton G.L. (Biol. Reprod. 2006)
    8. Binding of recombinant human proacrosin/acrosin to zona pellucida (ZP) glycoproteins. I. Studies with recombinant human ZPA, ZPB, and ZPC. (PubMed id 15950651)1, 9 Furlong L.I....Vazquez-Levin M.H. (Fertil. Steril. 2005)
    9. Proteolytic processing of human zona pellucida proteins. (PubMed id 11804956)1, 9 Kiefer S.M. and Saling P. (Biol. Reprod. 2002)
    10. Genetic and physiological study of morphologically abnormal human zona pellucida. (PubMed id 22889493)1 Margalit M....Kleiman S.E. (Eur. J. Obstet. Gynecol. Reprod. Biol. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7783 HGNC: 13188 AceView: ZP2 Ensembl:ENSG00000103310 euGenes: HUgn7783
    ECgene: ZP2 H-InvDB: ZP2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ZP2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for ZP2 gene:
    Search GeneIP for patents involving ZP2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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