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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ZP1 Gene

protein-coding GIFtS: 47
GCID: GC11P060635

zona pellucida glycoprotein 1 (sperm receptor)

Explore 8 diseases affiliated with
ZP1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Zona Pellucida Glycoprotein 1 (Sperm Receptor)¹ ²
Zona Pellucida Protein 1²
Zona Pellucida Sperm-Binding Protein 1²
Zp-1³
Zp-1³
Zona Pellucida Glycoprotein 1³

External Ids:	HGNC: 13187¹	Entrez Gene: 22917²	Ensembl: ENSG00000149506⁷	OMIM: 195000⁵	UniProtKB: P60852³

Export aliases for ZP1 gene to outside databases

Previous GC identifers: GC11U990202 GC11P060393 GC11P056981

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: ZP1_HUMAN, P60852

Function: The mammalian zona pellucida, which mediates species-specific sperm binding, induction of the acrosome

reaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, ZP1, ZP2, ZP3, and

ZP4. ZP1 ensures the structural integrity of the zona pellucida

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000011.9 NC_018922.1 NT_167190.1

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ZP1 gene promoter:
c-Fos GATA-3 AP-1 ATF-2 c-Jun GATA-1 GATA-2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ZP1 promoter sequence

Search SABiosciences Chromatin IP Primers for ZP1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZP1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q12.2 Ensembl cytogenetic band: 11q12.2 HGNC cytogenetic band: 11q12.2

ZP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZP1 gene location

GeneLoc information about chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11P060635: view genomic region (about GC identifiers)

Start:	60,635,015 bp from pter	End:	60,643,166 bp from pter
Size:	8,152 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ZP1_HUMAN, P60852 (See protein sequence)

Recommended Name: Zona pellucida sperm-binding protein 1 precursor

Size: 638 amino acids; 70049 Da

Subunit: Polymers of ZP2 and ZP3 organized into long filaments cross-linked by ZP1 homodimers (By similarity)

Subcellular location: Processed zona pellucida sperm-binding protein 1: Secreted, extracellular space, extracellular

matrix

Subcellular location: Cell membrane; Single-pass type I membrane protein

Explore the universe of human proteins at neXtProt for ZP1: NX_P60852

Post-translational modifications:

Proteolytically cleaved before the transmembrane segment to yield the secreted ectodomain incorporated in the zona

pellucida¹

O-glycosylated (By similarity)¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P60852

ZP1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_997224.2

ENSEMBL proteins:

ENSP00000278853 ENSP00000441293

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Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005578	proteinaceous extracellular matrix	IEA	--
GO:0005794	Golgi apparatus	IEA	--
GO:0005886	plasma membrane	IEA	--
GO:0016021	integral to membrane	IEA	--
GO:0030141	secretory granule	IEA	--

ZP1 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ZP1 for domains About GeneDecksing

4 InterPro domains/families:

IPR017977 ZP_dom_CS

IPR000519 P_trefoil

IPR001507 ZP_dom

IPR017957 P_trefoil_CS

Graphical View of Domain Structure for InterPro Entry P60852

ProtoNet protein and cluster: P60852

1 Blocks protein family: IPB000519 P-type trefoil domain

UniProtKB/Swiss-Prot: ZP1_HUMAN, P60852

Domain: The ZP domain is involved in the polymerization of the ZP proteins to form the zona pellucida

Similarity: Belongs to the ZP domain family. ZPB subfamily

Similarity: Contains 1 P-type (trefoil) domain

Similarity: Contains 1 ZP domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: ZP1_HUMAN, P60852

Function: The mammalian zona pellucida, which mediates species-specific sperm binding, induction of the acrosome

reaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, ZP1, ZP2, ZP3, and

ZP4. ZP1 ensures the structural integrity of the zona pellucida

Genatlas biochemistry entry for ZP1:

zona pellucida glycoprotein 1,sperm receptor,ortholog of the mouse Zp1 gene

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZP1

Animal Models:
Mouse knock-out Zp1^tm1Dean for ZP1
4 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Zp1):

endocrine/exocrine gland

hematopoietic system

immune system

reproductive system

ZP1 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for ZP1

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007338	single fertilization	IEA	--

ZP1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ZP1
Search CenterWatch for drugs/clinical trials and news about ZP1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
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About This Section

REFSEQ mRNAs for ZP1 gene:

NM_207341.2

Unigene Cluster for ZP1:

Zona pellucida glycoprotein 1 (sperm receptor)

Hs.172130 [show with all ESTs]

Unigene Representative Sequence: NM_207341

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000278853(uc001nqd.3) ENST00000540908 ENST00000537203(uc001nqe.3)

ENST00000542971 ENST00000543020

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Additional cDNA sequence: BC067899.1

2 DOTS entries:

DT.204486 DT.120716059

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for ZP1 About this scheme

ExUns:	1a	·	1b	^	2	^	3a	·	3b	·	3c	·	3d	·	3e	^	4	^	5	^	6a	·	6b	^	7	^	8
SP1:							-
SP2:
SP3:							-		-		-
SP4:

ECgene alternative splicing isoforms for ZP1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ZP1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TAGCACTGGC

About this image

ZP1 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

4 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Ovary

Ovigerous Cord

Ovum

Female Gametocytes, Germ Cells

Ovary

Antral Follicle

Secondary Oocyte

Female Gametocytes, Germ Cells

Ovary

Ovary

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 10/11 LifeMap Cells (see all 11)

Name

Category

ES-J1 (Embryonic Stem Cell)

Early Embryo, Inner Cell Mass

PureStem™ mesenchymal Progenitor SK11 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

PureStem™ mesenchymal progenitor 7PEND24 (Embryonic Progenitor Cell)

Cartilage, Neural Crest

PureStem™ progenitor EN7 (Embryonic Progenitor Cell)

PureStem™ progenitor W8 (Embryonic Progenitor Cell)

PureStem™ progenitor Z1 (Embryonic Progenitor Cell)

Secondary follicles (Primary Cell)

Ovary, Reproductive System

Long-time differentiated EBs (Derivation of embryo...)

Short-term differentiated embryoid bodies (Derivation of embryo...)

Oocytes (Oocyte formation by ...)

See ZP1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZP1

SOURCE GeneReport for Unigene cluster: Hs.172130

UniProtKB/Swiss-Prot: ZP1_HUMAN, P60852

Tissue specificity: Oocytes

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for ZP1 gene from 3/8 species (see all 8) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	ZP1¹	zona pellucida glycoprotein 1 (sperm receptor)	61.59(n) 55.04(a)		395418 NM_204683.1 NP_990014.1
lizard (Anolis carolinensis)	Reptilia	ZP1⁶	--	29(a)	1 ↔ 1	GL343235.1(339340-351230)
zebrafish (Danio rerio)	Actinopterygii	zp2l1⁶ zp2.2⁶ (see all 10)	zona pellucida glycoprotein 2.2 (see all 10)	34(a) 30(a) (see all 10)	many ↔ many many ↔ many (see all 10)	9(36684366-36686753) 20(54548463-54550280)

ENSEMBL Gene Tree for ZP1 (if available)
TreeFam Gene Tree for ZP1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ZP1 gene

ZP4² ZP2²

2 SIMAP similar genes for ZP1 using alignment to 3 protein entries: ZP1_HUMAN (see all proteins):

ZP4 ZP2

ZP1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs138797279^1,2		--	60633117(+)	`CCATTC/GCCCTC`	1	--	us2k¹		0	--	--	--	--
rs55652525^1,2	C,F,	--	60633250(+)	`AGAGAT/CGTGAT`	1	--	us2k¹		8		NA WA CSA EA	366
rs142606089^1,2		--	60633330(+)	`TTTTT-/CTTTTT`	1	--	us2k¹		0	--	--	--	--
rs201384570^1,2		--	60633357(+)	`ACAGA-/GTCT GTCTC`	1	--	us2k¹		0	--	--	--	--
rs2428459^1,2		--	60633367(-)	`ccgacA/Tgagtg`	1	--	us2k¹		0	--	--	--	--
rs2467638^1,2		--	60633371(+)	`cagtcG/Tgccag`	1	--	us2k¹		0	--	--	--	--
rs184935800^1,2		--	60633385(+)	`GGAGTA/GCAACA`	1	--	us2k¹		0	--	--	--	--
rs1232554^1,2	C,F,	--	60633406(-)	`tgcagC/Tgagcc`	1	--	us2k¹		4		NA CSA	8
rs189285775^1,2		--	60633499(+)	`GCTAAA/TTTTTG`	1	--	us2k¹		0	--	--	--	--
rs1232553^1,2	C,H,	--	60633532(-)	`TAACAC/TGGTGA`	1	--	us2k¹		6		NA CSA	10

HapMap Linkage Disequilibrium report for ZP1 (60635015 - 60643166 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ZP1: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZP1

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ZP1 for disorders           About GeneDecksing

OMIM gene information: 195000    OMIM disorders: --

8 diseases for ZP1:    About MalaCards

oophoritis bleeding disorder thrombophilia diphtheria

meningioma leukemia venous thromboembolism thromboembolism

3 diseases from the University of Copenhagen DISEASES database for ZP1:

Oophoritis Ovarian dysfunction Infertility

Genetic Association Database (GAD): ZP1
Human Genome Epidemiology (HuGE) Navigator: ZP1 (10 documents)

Export disorders for ZP1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ZP1 gene, integrated from 9 sources (see all 31):
(articles sorted by number of sources associating them with ZP1)

Utopia: connect your pdf to the dynamic
world of online information

Identification of the true human orthologue of the mouse Zp1 gene: evidence for greater complexity in the mammalian zona pellucida? (PubMed id 10542331)^{1, 2, 3, 9} Hughes D.C. and Barratt C.L. (1999)
Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)^{1, 2} Taylor T.D....Sakaki Y. (2006)
Association between sequence variations in genes encoding human zona pellucida glycoproteins and fertilization failure in IVF. (PubMed id 15860499)^{1, 4} Mannikko M....Lakkakorpi J.T. (2005)
Mutations within the protein Z-dependent protease inhibitor gene are associated with venous thromboembolic disease: a new form of thrombophilia. (PubMed id 15461625)^{1, 4} Van de Water N....Harper P. (2004)
Detection of zona pellucida proteins during human folliculogenesis. (PubMed id 18033806)^{1, 9} Gook D.A....Martic M. (2008)
Four zona pellucida glycoproteins are expressed in the human. (PubMed id 15142998)^{1, 9} Lefievre L....Barratt C.L. (2004)
Study of 18 functional hemostatic polymorphisms in mu cocutaneous bleeding disorders. (PubMed id 20532885)¹ AntA^n A.I....Mezzano D. (2010)
Polymorphisms in innate immunity genes and risk of ch ildhood leukemia. (PubMed id 20438785)¹ Han S....Kang D. (2010)
In humans, zona pellucida glycoprotein-1 binds to spe rmatozoa and induces acrosomal exocytosis. (PubMed id 20504872)¹ Ganguly A....Gupta S.K. (2010)
Risk of meningioma and common variation in genes rela ted to innate immunity. (PubMed id 20406964)¹ Rajaraman P....Inskip P.D. (2010)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 22917	HGNC: 13187	Ensembl:ENSG00000149506	euGenes: HUgn22917	ECgene: ZP1
H-InvDB: ZP1

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ZP1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ZP1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for ZP1 gene:
Search GeneIP for patents involving ZP1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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About This Section


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GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes ZP1 gene at Home site.

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ZP1 Gene

zona pellucida glycoprotein 1 (sperm receptor)

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ZP1 Gene

zona pellucida glycoprotein 1 (sperm receptor)

Aliasesfor ZP1 gene

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