Aliases for ZP1 Gene
External Ids for ZP1 Gene
Previous GeneCards Identifiers for ZP1 Gene
The zona pellucida is an extracellular matrix that surrounds the oocyte and early embryo. It is composed primarily of three or four glycoproteins with various functions during fertilization and preimplantation development. The protein encoded by this gene ensures the structural integrity of the zona pellucida. Mutations in this gene are a cause of oocyte maturation defect and infertility. [provided by RefSeq, May 2014]
GeneCards Summary for ZP1 Gene
ZP1 (Zona Pellucida Glycoprotein 1 (Sperm Receptor)) is a Protein Coding gene. Diseases associated with ZP1 include female infertility due to zona pellucida defect and oocyte maturation defect. Among its related pathways are Reproduction. An important paralog of this gene is ZP4.
UniProtKB/Swiss-Prot for ZP1 Gene
The mammalian zona pellucida, which mediates species-specific sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP1 ensures the structural integrity of the zona pellucida