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Aliases for ZP1 Gene

Aliases for ZP1 Gene

  • Zona Pellucida Glycoprotein 1 (Sperm Receptor) 2 3
  • Zona Pellucida Sperm-Binding Protein 1 3
  • Epididymis Luminal Protein 163 3
  • Zona Pellucida Glycoprotein 1 4
  • HEL163 3
  • OOMD 3
  • Zp-1 4

External Ids for ZP1 Gene

Previous GeneCards Identifiers for ZP1 Gene

  • GC11U990202
  • GC11P060393
  • GC11P060635
  • GC11P056981

Summaries for ZP1 Gene

Entrez Gene Summary for ZP1 Gene

  • The zona pellucida is an extracellular matrix that surrounds the oocyte and early embryo. It is composed primarily of three or four glycoproteins with various functions during fertilization and preimplantation development. The protein encoded by this gene ensures the structural integrity of the zona pellucida. Mutations in this gene are a cause of oocyte maturation defect and infertility. [provided by RefSeq, May 2014]

GeneCards Summary for ZP1 Gene

ZP1 (Zona Pellucida Glycoprotein 1 (Sperm Receptor)) is a Protein Coding gene. Diseases associated with ZP1 include oocyte maturation defect and female infertility due to zona pellucida defect. Among its related pathways are Reproduction and Reproduction. An important paralog of this gene is ZP4.

UniProtKB/Swiss-Prot for ZP1 Gene

  • The mammalian zona pellucida, which mediates species-specific sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP1 ensures the structural integrity of the zona pellucida

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZP1 Gene

Genomics for ZP1 Gene

Regulatory Elements for ZP1 Gene

Genomic Location for ZP1 Gene

Start:
60,867,542 bp from pter
End:
60,875,693 bp from pter
Size:
8,152 bases
Orientation:
Plus strand

Genomic View for ZP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZP1 Gene

Proteins for ZP1 Gene

  • Protein details for ZP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P60852-ZP1_HUMAN
    Recommended name:
    Zona pellucida sperm-binding protein 1
    Protein Accession:
    P60852
    Secondary Accessions:

    Protein attributes for ZP1 Gene

    Size:
    638 amino acids
    Molecular mass:
    70049 Da
    Quaternary structure:
    • Polymers of ZP2 and ZP3 organized into long filaments cross-linked by ZP1 homodimers.

neXtProt entry for ZP1 Gene

Proteomics data for ZP1 Gene at MOPED

Post-translational modifications for ZP1 Gene

  • O-glycosylated.
  • Proteolytically cleaved before the transmembrane segment to yield the secreted ectodomain incorporated in the zona pellucida
  • Glycosylation at Asn76, Asn379, Asn561, and Asn596
  • Modification sites at PhosphoSitePlus

Other Protein References for ZP1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for ZP1 Gene

Domains for ZP1 Gene

Gene Families for ZP1 Gene

HGNC:
  • ZP :Zona pellucida glycoproteins

Protein Domains for ZP1 Gene

Suggested Antigen Peptide Sequences for ZP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P60852

UniProtKB/Swiss-Prot:

ZP1_HUMAN :
  • P60852
Domain:
  • The ZP domain is involved in the polymerization of the ZP proteins to form the zona pellucida
  • Belongs to the ZP domain family. ZPB subfamily.
  • Contains 1 P-type (trefoil) domain.
  • Contains 1 ZP domain.
genes like me logo Genes that share domains with ZP1: view

Function for ZP1 Gene

Molecular function for ZP1 Gene

GENATLAS Biochemistry: zona pellucida glycoprotein 1,sperm receptor,ortholog of the mouse Zp1 gene
UniProtKB/Swiss-Prot Function: The mammalian zona pellucida, which mediates species-specific sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP1 ensures the structural integrity of the zona pellucida
genes like me logo Genes that share phenotypes with ZP1: view

Animal Models for ZP1 Gene

MGI Knock Outs for ZP1:

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , miRNA , Transcription Factor Targeting and HOMER Transcription for ZP1 Gene

Localization for ZP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZP1 Gene

Processed zona pellucida sperm-binding protein 1: Secreted, extracellular space, extracellular matrix. Note=The glycoproteinaceous translucent extracellular matrix that surrounds the mammalian oocyte is called zona pellucida.
Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZP1 Gene COMPARTMENTS Subcellular localization image for ZP1 gene
Compartment Confidence
extracellular 5
plasma membrane 5
golgi apparatus 2
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for ZP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005578 proteinaceous extracellular matrix IEA --
GO:0005794 Golgi apparatus IEA --
GO:0005886 plasma membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ZP1: view

Pathways for ZP1 Gene

SuperPathways for ZP1 Gene

Superpath Contained pathways
1 Reproduction
genes like me logo Genes that share pathways with ZP1: view

Pathways by source for ZP1 Gene

Interacting Proteins for ZP1 Gene

Gene Ontology (GO) - Biological Process for ZP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007338 single fertilization TAS --
GO:0007339 binding of sperm to zona pellucida TAS --
GO:0032504 multicellular organism reproduction TAS --
genes like me logo Genes that share ontologies with ZP1: view

Transcripts for ZP1 Gene

mRNA/cDNA for ZP1 Gene

(3) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZP1 Gene

Zona pellucida glycoprotein 1 (sperm receptor):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZP1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c · 3d · 3e ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8
SP1: -
SP2:
SP3: - - -
SP4:

Relevant External Links for ZP1 Gene

GeneLoc Exon Structure for
ZP1
ECgene alternative splicing isoforms for
ZP1

Expression for ZP1 Gene

mRNA expression in normal human tissues for ZP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ZP1 Gene

This gene is overexpressed in Pituitary (23.3) and Testis (7.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ZP1 Gene

SOURCE GeneReport for Unigene cluster for ZP1 Gene Hs.172130

mRNA Expression by UniProt/SwissProt for ZP1 Gene

P60852-ZP1_HUMAN
Tissue specificity: Oocytes
genes like me logo Genes that share expressions with ZP1: view

Orthologs for ZP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZP1 35
  • 99.32 (n)
  • 98.59 (a)
ZP1 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zp1 35
  • 75.41 (n)
  • 68.57 (a)
Zp1 16
Zp1 36
  • 67 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZP1 36
  • 42 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZP1 36
  • 51 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zp1 35
  • 76.09 (n)
  • 70.02 (a)
chicken
(Gallus gallus)
Aves ZP1 35
  • 64.08 (n)
  • 54.92 (a)
ZP1 36
  • 27 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZP1 36
  • 27 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii CABZ01051901.1 36
  • 11 (a)
ManyToMany
CABZ01074647.1 36
  • 24 (a)
ManyToMany
si:zfos-1505d6.3 36
  • 30 (a)
ManyToMany
zp2.1 36
  • 30 (a)
ManyToMany
zp2.2 36
  • 31 (a)
ManyToMany
zp2.3 36
  • 30 (a)
ManyToMany
zp2.5 36
  • 31 (a)
ManyToMany
zp2.6 36
  • 30 (a)
ManyToMany
zp2l1 36
  • 35 (a)
ManyToMany
zp2l2 36
  • 31 (a)
ManyToMany
Species with no ortholog for ZP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZP1 Gene

ENSEMBL:
Gene Tree for ZP1 (if available)
TreeFam:
Gene Tree for ZP1 (if available)

Paralogs for ZP1 Gene

Paralogs for ZP1 Gene

Selected SIMAP similar genes for ZP1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ZP1: view

Variants for ZP1 Gene

Sequence variations from dbSNP and Humsavar for ZP1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs489172 - 60,869,691(-) GTGGG(A/G)TTGAG reference, missense
rs502412 -- 60,873,384(-) AGCTG(A/C)AGGTC missense, reference
rs544860 -- 60,868,238(-) GAAAC(C/T)CCATC intron-variant
rs550479 -- 60,867,618(-) GTGGC(A/G)ACCAG synonymous-codon, reference
rs566411 -- 60,870,997(-) GACAC(C/T)ACGAG synonymous-codon, reference

Structural Variations from Database of Genomic Variants (DGV) for ZP1 Gene

Variant ID Type Subtype PubMed ID
nsv897598 CNV Loss 21882294

Relevant External Links for ZP1 Gene

HapMap Linkage Disequilibrium report
ZP1
Human Gene Mutation Database (HGMD)
ZP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZP1 Gene

Disorders for ZP1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (3) Diseases for ZP1 Gene including...

Search for ZP1 Gene in MalaCards »

UniProtKB/Swiss-Prot

ZP1_HUMAN
  • Oocyte maturation defect (OOMD) [MIM:615774]: An infertility disorder caused by defective oocyte maturation that results in abnormal eggs lacking a zona pellucida. Affected females have normal menstrual cycles and sex hormone levels, no obstruction in the fallopian tubes or abnormalities of the uterus or adnexa. {ECO:0000269 PubMed:24670168}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(3) University of Copenhagen DISEASES for ZP1 Gene

Relevant External Links for ZP1

Genetic Association Database (GAD)
ZP1
Human Genome Epidemiology (HuGE) Navigator
ZP1
genes like me logo Genes that share disorders with ZP1: view

Publications for ZP1 Gene

  1. Identification of the true human orthologue of the mouse Zp1 gene: evidence for greater complexity in the mammalian zona pellucida? (PMID: 10542331) Hughes D.C. … Barratt C.L. (Biochim. Biophys. Acta 1999) 2 3 4 23
  2. Four zona pellucida glycoproteins are expressed in the human. (PMID: 15142998) LefiA"vre L. … Barratt C.L. (Hum. Reprod. 2004) 3 23
  3. Detection of zona pellucida proteins during human folliculogenesis. (PMID: 18033806) Gook D.A. … Martic M. (Hum. Reprod. 2008) 3 23
  4. Mutations within the protein Z-dependent protease inhibitor gene are associated with venous thromboembolic disease: a new form of thrombophilia. (PMID: 15461625) Van de Water N. … Harper P. (Br. J. Haematol. 2004) 3 48
  5. Association between sequence variations in genes encoding human zona pellucida glycoproteins and fertilization failure in IVF. (PMID: 15860499) MAonnikkAP M. … Lakkakorpi J.T. (Hum. Reprod. 2005) 3 48

Products for ZP1 Gene

Sources for ZP1 Gene

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