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ZP1 Gene

protein-coding   GIFtS: 52
GCID: GC11P060635

Zona Pellucida Glycoprotein 1 (Sperm Receptor)

  See ZP1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zona Pellucida Glycoprotein 1 (Sperm Receptor)1 2     Zona Pellucida Sperm-Binding Protein 12
HEL1632     zp-12
Epididymis Luminal Protein 1632     Zp-13
Zona Pellucida Protein 12     Zona Pellucida Glycoprotein 13

External Ids:    HGNC: 131871   Entrez Gene: 229172   Ensembl: ENSG000001495067   OMIM: 1950005   UniProtKB: P608523   

Export aliases for ZP1 gene to outside databases

Previous GC identifers: GC11U990202 GC11P060393 GC11P056981


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZP1 Gene:
ZP1 (zona pellucida glycoprotein 1 (sperm receptor)) is a protein-coding gene. Diseases associated with ZP1 include female infertility due to zona pellucida defect, and oocyte maturation defect. An important paralog of this gene is ZP4.

UniProtKB/Swiss-Prot: ZP1_HUMAN, P60852
Function: The mammalian zona pellucida, which mediates species-specific sperm binding, induction of the acrosome
reaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, ZP1, ZP2, ZP3,
and ZP4. ZP1 ensures the structural integrity of the zona pellucida




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NC_018922.2  NT_167190.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZP1 gene promoter:
         c-Fos   GATA-3   AP-1   ATF-2   c-Jun   GATA-1   GATA-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZP1 promoter sequence
   Search Chromatin IP Primers for ZP1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q12.2   Ensembl cytogenetic band:  11q12.2   HGNC cytogenetic band: 11q12.2

ZP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZP1 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P060635:  view genomic region     (about GC identifiers)

Start:
60,635,015 bp from pter      End:
60,643,166 bp from pter
Size:
8,152 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ZP1_HUMAN, P60852 (See protein sequence)
Recommended Name: Zona pellucida sperm-binding protein 1 precursor  
Size: 638 amino acids; 70049 Da
Subunit: Polymers of ZP2 and ZP3 organized into long filaments cross-linked by ZP1 homodimers (By similarity)

Explore the universe of human proteins at neXtProt for ZP1: NX_P60852

Explore proteomics data for ZP1 at MOPED

Post-translational modifications: 

  • Proteolytically cleaved before the transmembrane segment to yield the secreted ectodomain incorporated in the zona
    pellucida1
  • O-glycosylated (By similarity)1
  • Glycosylation2 at Asn76, Asn379, Asn561, Asn596
  • Modification sites at PhosphoSitePlus

  • See ZP1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_997224.2  
    ENSEMBL proteins: 
     ENSP00000278853   ENSP00000441293  
    Reactome Protein details: P60852

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZP: Zona pellucida glycoproteins

    4 InterPro protein domains:
     IPR017977 ZP_dom_CS
     IPR000519 P_trefoil
     IPR017957 P_trefoil_CS
     IPR001507 ZP_dom

    Graphical View of Domain Structure for InterPro Entry P60852

    ProtoNet protein and cluster: P60852

    1 Blocks protein domain: IPB000519 P-type trefoil domain

    UniProtKB/Swiss-Prot: ZP1_HUMAN, P60852
    Domain: The ZP domain is involved in the polymerization of the ZP proteins to form the zona pellucida
    Similarity: Belongs to the ZP domain family. ZPB subfamily
    Similarity: Contains 1 P-type (trefoil) domain
    Similarity: Contains 1 ZP domain


    Find genes that share domains with ZP1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZP1_HUMAN, P60852
    Function: The mammalian zona pellucida, which mediates species-specific sperm binding, induction of the acrosome
    reaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, ZP1, ZP2, ZP3,
    and ZP4. ZP1 ensures the structural integrity of the zona pellucida

         Genatlas biochemistry entry for ZP1:
    zona pellucida glycoprotein 1,sperm receptor,ortholog of the mouse Zp1 gene

    Phenotypes:
         4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Zp1):
     endocrine/exocrine gland  hematopoietic system  immune system  reproductive system 

    Find genes that share phenotypes with ZP1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Zp1tm1Dean for ZP1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ZP1
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZP1_HUMAN, P60852: Processed zona pellucida sperm-binding protein 1: Secreted, extracellular space,
    extracellular matrix. Note=The glycoproteinaceous translucent extracellular matrix that surrounds the mammalian
    oocyte is called zona pellucida
    ZP1_HUMAN, P60852: Cell membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    plasma membrane5
    golgi apparatus2
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005578proteinaceous extracellular matrix IEA--
    GO:0005794Golgi apparatus IEA--
    GO:0005886plasma membrane IEA--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with ZP1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ZP1 About    
    See pathways by source

    SuperPathContained pathways About
    1Reproduction
    Reproduction1.00
    Interaction With The Zona Pellucida0.00
    Fertilization1.00


    Find genes that share SuperPaths with ZP1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for ZP1
        Interaction With The Zona Pellucida


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZP1
    Interactions:

        Search GeneGlobe Interaction Network for ZP1

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007338single fertilization TAS--
    GO:0007339binding of sperm to zona pellucida TAS--
    GO:0032504multicellular organism reproduction TAS--

    Find genes that share ontologies with ZP1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZP1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ZP1 gene: 
    NM_207341.3  

    Unigene Cluster for ZP1:

    Zona pellucida glycoprotein 1 (sperm receptor)
    Hs.172130  [show with all ESTs]
    Unigene Representative Sequence: NM_207341
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000278853(uc001nqd.3) ENST00000540908 ENST00000537203(uc001nqe.3)
    ENST00000542971 ENST00000543020
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    Additional mRNA sequence: BC067899.1 

    2 DOTS entries:

    DT.204486  DT.120716059 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for ZP1    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c · 3d · 3e ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8
    SP1:                    -                                                               
    SP2:                                                                                    
    SP3:                    -     -     -                                                   
    SP4:                                                                                    


    ECgene alternative splicing isoforms for ZP1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAGCACTGGC
    ZP1 Expression
    About this image


    ZP1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Ovary (Reproductive System)    fully expand to see all 6 entries
             Pre-Granulosa Cells Primordial Follicle
             Secondary follicles
             Oocytes
     
     Paraxial Mesoderm (Gastrulation Derivatives)    fully expand to see all 2 entries
             PureStem SK11, NCr-fac & Meso-prx Progenitor
     
     Neural Crest (Gastrulation Derivatives)    fully expand to see all 2 entries
             PureStem SK11, NCr-fac & Meso-prx Progenitor
     
     Gonad
             Secondary Oocyte Antral Follicle
     
     NULL (Uncategorized)    fully expand to see all 2 entries
             Short-term differentiated embryoid bodies
    ZP1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZP1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.172130

    UniProtKB/Swiss-Prot: ZP1_HUMAN, P60852
    Tissue specificity: Oocytes

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ZP1 gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zp11 , 5 zona pellucida glycoprotein 11, 5 75.41(n)1
    68.57(a)1
      19 (7.36 cM)5
    227861  NM_009580.21  NP_033606.21 
     109142875 
    chicken
    (Gallus gallus)
    Aves ZP11 zona pellucida glycoprotein 1 (sperm receptor) 64.08(n)
    54.92(a)
      395418  NM_204683.1  NP_990014.1 
    lizard
    (Anolis carolinensis)
    Reptilia ZP16
    zona pellucida glycoprotein 1 (sperm receptor)
    27(a)
    1 ↔ 1
    GL343235.1(339340-351967)
    zebrafish
    (Danio rerio)
    Actinopterygii zp2l16
    zp2.56
    (see all 10)
    zona pellucida glycoprotein 2, tandem duplicate 5
    (see all 10)
    35(a)
    31(a)
    (see all 10)
    many ↔ many
    many ↔ many
    (see all 10)
    9(36684366-36686753) ENSDARG00000055415
    20(54571077-54572927) ENSDARG00000086522


    ENSEMBL Gene Tree for ZP1 (if available)
    TreeFam Gene Tree for ZP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZP1 gene
    ZP42  ZP22  
    2 SIMAP similar genes for ZP1 using alignment to 3 protein entries:     ZP1_HUMAN (see all proteins):
    ZP4    ZP2

    Find genes that share paralogs with ZP1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZP1 (see all 302)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1387972791,2
    --60633117(+) CCATTC/GCCCTC 1 -- us2k10--------
    rs556525251,2
    C,F--60633250(+) AGAGAT/CGTGAT 1 -- us2k18Minor allele frequency- C:0.29NA WA CSA EA 366
    rs1426060891,2
    --60633330(+) TTTTT-/CTTTTT 1 -- us2k10--------
    rs2013845701,2
    C--60633357(+) ACAGA-/GTCT  
            
    GTCTC
    1 -- us2k10--------
    rs24284591,2
    C--60633367(-) ccgacA/Tgagtg 1 -- us2k10--------
    rs24676381,2
    C--60633371(+) cagtcA/G/Tgccag 1 -- us2k10--------
    rs1849358001,2
    --60633385(+) GGAGTA/GCAACA 1 -- us2k10--------
    rs12325541,2
    C,F--60633406(-) tgcagC/Tgagcc 1 -- us2k14Minor allele frequency- T:0.38NA CSA 8
    rs1892857751,2
    --60633499(+) GCTAAA/TTTTTG 1 -- us2k10--------
    rs12325531,2
    C,H--60633532(-) taacaC/Tggtga 1 -- us2k16Minor allele frequency- T:0.00NA CSA 10

    HapMap Linkage Disequilibrium report for ZP1 (60635015 - 60643166 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for ZP1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv897598CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ZP1
    DNA2.0 Custom Variant and Variant Library Synthesis for ZP1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 195000    OMIM disorders: --

    3 diseases for ZP1:    
    About MalaCards
    female infertility due to zona pellucida defect    oocyte maturation defect    oophoritis

    3 diseases from the University of Copenhagen DISEASES database for ZP1:
    Oophoritis     Ovarian dysfunction     Infertility

    Find genes that share disorders with ZP1           About GenesLikeMe

    Genetic Association Database (GAD): ZP1
    Human Genome Epidemiology (HuGE) Navigator: ZP1 (10 documents)

    Export disorders for ZP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZP1 gene, integrated from 10 sources (see all 32):
    (articles sorted by number of sources associating them with ZP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of the true human orthologue of the mouse Zp1 gene: evidence for greater complexity in the mammalian zona pellucida? (PubMed id 10542331)1, 2, 3, 9 Hughes D.C. and Barratt C.L. (Biochim. Biophys. Acta 1999)
    2. Risk of meningioma and common variation in genes related to innate immunity. (PubMed id 20406964)1, 4 Rajaraman P....Inskip P.D. (amp 2010)
    3. Study of 18 functional hemostatic polymorphisms in mucocutaneous bleeding disorders. (PubMed id 20532885)1, 4 AntA^n A.I....Mezzano D. (Ann. Hematol. 2010)
    4. Polymorphisms in innate immunity genes and risk of childhood leukemia. (PubMed id 20438785)1, 4 Han S....Kang D. (Hum. Immunol. 2010)
    5. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)1, 2 Taylor T.D....Sakaki Y. (Nature 2006)
    6. Association between sequence variations in genes encoding human zona pellucida glycoproteins and fertilization failure in IVF. (PubMed id 15860499)1, 4 MAonnikkAP M....Lakkakorpi J.T. (Hum. Reprod. 2005)
    7. Mutations within the protein Z-dependent protease inhibitor gene are associated with venous thromboembolic disease: a new form of thrombophilia. (PubMed id 15461625)1, 4 Van de Water N....Harper P. (Br. J. Haematol. 2004)
    8. Detection of zona pellucida proteins during human folliculogenesis. (PubMed id 18033806)1, 9 Gook D.A....Martic M. (Hum. Reprod. 2008)
    9. Four zona pellucida glycoproteins are expressed in the human. (PubMed id 15142998)1, 9 LefiA"vre L....Barratt C.L. (Hum. Reprod. 2004)
    10. Genetic and physiological study of morphologically abnormal human zona pellucida. (PubMed id 22889493)1 Margalit M....Kleiman S.E. (Eur. J. Obstet. Gynecol. Reprod. Biol. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 22917 HGNC: 13187 Ensembl:ENSG00000149506 euGenes: HUgn22917 ECgene: ZP1
    H-InvDB: ZP1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZP1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZP1 gene:
    Search GeneIP for patents involving ZP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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