ZNRF4 Gene
protein-coding GIFtS: 46
GCID: GC19P005455
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zinc and ring finger 4
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Aliases
for ZNRF4 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc And Ring Finger 41 2 | | RING Finger Protein 2042 3 | | RNF2041 2 3 | | SPERIZIN2 5 | | Ssrzf11 2 | | Zinc/RING Finger Protein 42 | | Spzn1 | | |
Export aliases for ZNRF4 gene to outside databasesPrevious GC identifers: GC19P005407 GC19P005216 |
Summaries
for ZNRF4 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for ZNRF4 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011255.14
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZNRF4 gene promoter:
USF1 USF2 USF-1:USF-2 Tal-1beta FOXC1 USF-1 c-Myb NF-Y ITF-2 CBF(2)
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZNRF4
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNRF4 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19p13.3 Ensembl cytogenetic band: 19p13.3 HGNC cytogenetic band: 19p13.3ZNRF4 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P005455: view genomic region
(about GC identifiers)
Start:
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5,455,426 bp from pter |
End:
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5,456,867 bp from pter |
Size:
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1,442 bases |
Orientation:
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plus strand |
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Proteins
for ZNRF4 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZNRF4_HUMAN, Q8WWF5 (See
protein sequence)Recommended Name: Zinc/RING finger protein 4 precursor Size: 429 amino acids; 46958 Da
Subcellular location: Membrane; Single-pass type I membrane protein (Potential)
Secondary accessions: A8K886 O75866Explore the universe of human proteins at neXtProt for ZNRF4: NX_Q8WWF5
ZNRF4 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_859061.3
ENSEMBL proteins: ENSP00000222033
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005737 | cytoplasm |
IEA | -- | | GO:0016021 | integral to membrane |
IEA | -- |
ZNRF4 for ontologies About GeneDecksing
ZNRF4 Antibody Products:
Assay Products for ZNRF4: |
Protein
Domains /
Families
for ZNRF4 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZNRF4 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8WWF5ProtoNet protein and cluster: Q8WWF5 1 Blocks protein family: IPB001841 Zn-finger
UniProtKB/Swiss-Prot: ZNRF4_HUMAN, Q8WWF5Similarity: Contains 1 PA (protease associated) domainSimilarity: Contains 1 RING-type zinc finger |
Function
for ZNRF4 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNRF4 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNRF4
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: ZNRF4 (NM_181710) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNRF4 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNRF4 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNRF4 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008270 | zinc ion binding |
IEA | -- |
ZNRF4 for ontologies About GeneDecksing
3 GenomeRNAi human phenotypes for ZNRF4:
|
Pathways & Interactions
for ZNRF4 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNRF4
STRING Interaction
Network Preview (showing 5 interactants - click image to see 10)
5/11 Interacting proteins for ZNRF4 (Q8WWF53 ENSP000002220334) via UniProtKB, MINT, STRING, and/or I2D (see all 11)About this table
|
Drugs & Compounds
for ZNRF4 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZNRF4
Search CenterWatch for drugs/clinical trials and news about ZNRF4
|
Transcripts
for ZNRF4 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZNRF4 gene: NM_181710.3 Unigene Cluster for ZNRF4: Zinc and ring finger 4 Hs.126496 [show with all ESTs]Unigene Representative Sequence: NM_1817101 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000222033(uc002mca.4)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNRF4 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNRF4
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ZNRF4 (NM_181710) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNRF4 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNRF4 |
Additional cDNA sequence: AK098722.1 AK292251.1 BC017592.2 2 DOTS entries: DT.75125917 DT.100016626 24 AceView cDNA sequences: BI831718 AK098722 NM_181710 BC017592 BX112977 BI828743 BI828780 BI829836 BI829818 BI829749 BI825889 BI559820 BI461784 BG718282 CD557346 AI283610 AL037542 BG771629 BG771998 BM560509 BM553047 AA913749 AI807507 BU561397
GeneLoc Exon Structure
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Expression
for ZNRF4 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZNRF4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGGTGGCCAC
About this image
See ZNRF4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZNRF4
SOURCE GeneReport for Unigene cluster: Hs.126496
SABiosciences Custom PCR Arrays for ZNRF4
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNRF4
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ZNRF4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNRF4 | | | Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNRF4 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNRF4 |
Orthologs
for ZNRF4 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for ZNRF4 gene from 6/22 species (see all 22) About this table
ENSEMBL Gene Tree for ZNRF4 (if available)
TreeFam Gene Tree for ZNRF4 (if available) |
Paralogs
for ZNRF4 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ZNRF4 gene
- ZNRF32 RNF432 RNF1482 RNF1492 RNF1332 RNF1302 RNF1502 RNF1672
- RNF1282 RNF2152 RNF132
2 SIMAP similar genes for ZNRF4 using alignment to 1 protein entry: ZNRF4_HUMAN:RNF13 RNF167
ZNRF4 for paralogs About GeneDecksing
|
Genomic Variants
for ZNRF4 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZNRF4 (5455426 - 5456867 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for ZNRF4
1 CNV: 50191 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNRF4 |
|
Disorders
/ Diseases
for ZNRF4 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ZNRF4 for disorders About GeneDecksing
OMIM gene information: 612063
OMIM disorders: --
3  diseases for ZNRF4: About MalaCardsautosomal recessive nonsyndromic deafness nonsyndromic deafness prostatitis
1 disease from the University of Copenhagen DISEASES database for ZNRF4:Prostatitis Export disorders for ZNRF4 gene to outside databases
|
Publications
for ZNRF4 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZNRF4 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ZNRF4) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- A systematic search for endoplasmic reticulum (ER) me mbrane-associated RING finger proteins identifies Nixin/ZNRF4 as a regulator of calnexin stability and ER homeostasis. (PubMed id 21205830)1 Neutzner A....Karbowski M. (2011)
- A comprehensive framework of E2-RING E3 interactions of the human ubiquitin-proteasome system. (PubMed id 19690564)1 van Wijk S.J....Timmers H.T. (2009)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Sperizin is a murine RING zinc-finger protein specifically expressed in Haploid germ cells. (PubMed id 10191088)1 Fujii T....Abiko Y. (1999)
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External Searches for ZNRF4 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing ZNRF4 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZNRF4 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZNRF4 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZNRF4 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for ZNRF4 gene:
Search GeneIP for patents involving ZNRF4
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZNRF4 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ZNRF4 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZNRF4 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNRF4 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ZNRF4 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNRF4 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNRF4 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for ZNRF4 | | OriGene Custom Protein Services for ZNRF4 | | | OriGene Custom Immunoassay Development | | |
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| | | | Search Tocris compounds for ZNRF4 |
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 | | | ZNRF4 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNRF4 |
|  |  |  | | | | Search ThermoFisher Antibodies for ZNRF4 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNRF4 |
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