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Aliases for ZNRF4 Gene

Aliases for ZNRF4 Gene

  • Zinc And Ring Finger 4 2 3
  • RING Finger Protein 204 3 4
  • SPERIZIN 3 6
  • RNF204 3 4
  • Nixin 2 3
  • Zinc/RING Finger Protein 4 3
  • Sperizin 2
  • Ssrzf1 3
  • Spzn 3

External Ids for ZNRF4 Gene

Previous GeneCards Identifiers for ZNRF4 Gene

  • GC19P005407
  • GC19P005216

Summaries for ZNRF4 Gene

GeneCards Summary for ZNRF4 Gene

ZNRF4 (Zinc And Ring Finger 4) is a Protein Coding gene. An important paralog of this gene is RNF167.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNRF4 Gene

Genomics for ZNRF4 Gene

Regulatory Elements for ZNRF4 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ZNRF4 Gene

5,455,415 bp from pter
5,456,856 bp from pter
1,442 bases
Plus strand

Genomic View for ZNRF4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNRF4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNRF4 Gene

Proteins for ZNRF4 Gene

  • Protein details for ZNRF4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc/RING finger protein 4
    Protein Accession:
    Secondary Accessions:
    • A8K886
    • O75866

    Protein attributes for ZNRF4 Gene

    429 amino acids
    Molecular mass:
    46958 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNRF4 Gene

Proteomics data for ZNRF4 Gene at MOPED

Post-translational modifications for ZNRF4 Gene

  • Glycosylation at Asn107, Asn152, and Asn229
  • Modification sites at PhosphoSitePlus

Other Protein References for ZNRF4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNRF4 Gene

Domains for ZNRF4 Gene

Gene Families for ZNRF4 Gene

Protein Domains for ZNRF4 Gene

Suggested Antigen Peptide Sequences for ZNRF4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 PA (protease associated) domain.
  • Contains 1 RING-type zinc finger.
  • Contains 1 PA (protease associated) domain.
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with ZNRF4: view

Function for ZNRF4 Gene

Gene Ontology (GO) - Molecular Function for ZNRF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding --
genes like me logo Genes that share ontologies with ZNRF4: view
genes like me logo Genes that share phenotypes with ZNRF4: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNRF4

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZNRF4 Gene

Localization for ZNRF4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNRF4 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for ZNRF4 Gene COMPARTMENTS Subcellular localization image for ZNRF4 gene
Compartment Confidence
plasma membrane 3
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for ZNRF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ZNRF4: view

Pathways for ZNRF4 Gene

SuperPathways for ZNRF4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNRF4 Gene


No data available for Pathways by source for ZNRF4 Gene

Transcripts for ZNRF4 Gene

mRNA/cDNA for ZNRF4 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(24) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNRF4 Gene

Zinc and ring finger 4:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNRF4

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNRF4 Gene

No ASD Table

Relevant External Links for ZNRF4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNRF4 Gene

mRNA expression in normal human tissues for ZNRF4 Gene

mRNA differential expression in normal tissues according to GTEx for ZNRF4 Gene

This gene is overexpressed in Testis (52.2).

SOURCE GeneReport for Unigene cluster for ZNRF4 Gene Hs.126496

genes like me logo Genes that share expressions with ZNRF4: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for ZNRF4 Gene

Orthologs for ZNRF4 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNRF4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ZNRF4 35
  • 75.78 (n)
  • 68.1 (a)
ZNRF4 36
  • 59 (a)
(Canis familiaris)
Mammalia ZNRF4 35
  • 81.83 (n)
  • 75.42 (a)
ZNRF4 36
  • 66 (a)
(Mus musculus)
Mammalia Znrf4 35
  • 67.91 (n)
  • 56.61 (a)
Znrf4 16
Znrf4 36
  • 54 (a)
(Pan troglodytes)
Mammalia ZNRF4 35
  • 97.38 (n)
  • 94.76 (a)
ZNRF4 36
  • 94 (a)
(Rattus norvegicus)
Mammalia Znrf4 35
  • 65.71 (n)
  • 56.09 (a)
(Monodelphis domestica)
Mammalia ZNRF4 36
  • 54 (a)
(Ornithorhynchus anatinus)
Mammalia ZNRF4 36
  • 41 (a)
(Anolis carolinensis)
Reptilia ZNRF4 36
  • 37 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10277 36
  • 18 (a)
(Caenorhabditis elegans)
Secernentea C18B12.4 36
  • 15 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.598 36
  • 23 (a)
Species with no ortholog for ZNRF4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for ZNRF4 Gene

Gene Tree for ZNRF4 (if available)
Gene Tree for ZNRF4 (if available)

Paralogs for ZNRF4 Gene

(2) SIMAP similar genes for ZNRF4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ZNRF4: view

Variants for ZNRF4 Gene

Sequence variations from dbSNP and Humsavar for ZNRF4 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs381255 -- 5,454,752(-) GCACC(G/T)CCAGG upstream-variant-2KB
rs420325 -- 5,455,785(-) ACCAC(C/T)GCCTG reference, synonymous-codon
rs1055022 -- 5,456,640(+) CCCAT(C/T)TGGGC reference, synonymous-codon
rs1055023 -- 5,456,786(+) AAGAT(C/T)TAGGG utr-variant-3-prime
rs1564759 -- 5,455,252(-) CAGGG(C/T)ATCTT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ZNRF4 Gene

Variant ID Type Subtype PubMed ID
nsv510751 CNV Loss 20534489
nsv833726 CNV Loss 17160897
dgv3692n71 CNV Loss 21882294
nsv470118 CNV Loss 18288195
nsv516923 CNV Loss 19592680

Relevant External Links for ZNRF4 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNRF4 Gene

Disorders for ZNRF4 Gene

(1) University of Copenhagen DISEASES for ZNRF4 Gene

genes like me logo Genes that share disorders with ZNRF4: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships , Genatlas and External Links for ZNRF4 Gene

Publications for ZNRF4 Gene

  1. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. A systematic search for endoplasmic reticulum (ER) membrane-associated RING finger proteins identifies Nixin/ZNRF4 as a regulator of calnexin stability and ER homeostasis. (PMID: 21205830) Neutzner A. … Karbowski M. (J. Biol. Chem. 2011) 2 3
  4. Sperizin is a murine RING zinc-finger protein specifically expressed in Haploid germ cells. (PMID: 10191088) Fujii T. … Abiko Y. (Genomics 1999) 2 3
  5. A comprehensive framework of E2-RING E3 interactions of the human ubiquitin-proteasome system. (PMID: 19690564) van Wijk S.J. … Timmers H.T. (Mol. Syst. Biol. 2009) 3

Products for ZNRF4 Gene

Sources for ZNRF4 Gene

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