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Aliases for ZNRF4 Gene

Aliases for ZNRF4 Gene

  • Zinc And Ring Finger 4 2 3 5
  • Nixin 2 3 4
  • Zinc/RING Finger Protein 4 3 4
  • RING Finger Protein 204 3 4
  • Sperizin 2 3
  • RNF204 3 4
  • E3 Ubiquitin-Protein Ligase ZNRF4 3
  • EC 6.3.2.- 4
  • Ssrzf1 3
  • Spzn 3

External Ids for ZNRF4 Gene

Previous GeneCards Identifiers for ZNRF4 Gene

  • GC19P005407
  • GC19P005216

Summaries for ZNRF4 Gene

GeneCards Summary for ZNRF4 Gene

ZNRF4 (Zinc And Ring Finger 4) is a Protein Coding gene. An important paralog of this gene is RNF13.

UniProtKB/Swiss-Prot for ZNRF4 Gene

  • E3 ubiquitin-protein ligase which specifically induces ubiquitination and proteasomal degradation of CANX within the endoplasmic reticulum (PubMed:21205830). Could have a role in spermatogenesis (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNRF4 Gene

Genomics for ZNRF4 Gene

Regulatory Elements for ZNRF4 Gene

Enhancers for ZNRF4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F005484 0.2 ENCODE 12.8 +29.3 29299 0.8 ELF3 PKNOX1 MLX ARID4B DMAP1 THRB RARA YY1 SCRT2 CREM ZNRF4 PTPRS GC19M005474 GC19M005512
GH19F005398 0.5 ENCODE 12.3 -56.9 -56904 0.1 ZNF664 ZNF792 ADNP ZKSCAN8 ZNRF4 PTPRS GC19P005411
GH19F005499 0.5 ENCODE 12.2 +43.9 43910 0.2 POLR2A CTBP2 ZNRF4 GC19M005512 GC19M005474
GH19F005547 0.2 ENCODE 11.6 +92.7 92650 0.2 CTCF ZNF362 ZNF654 MAX ZNF384 REST ZNF2 RAD21 ZNF143 SMC3 ZNRF4 GC19M005554 GC19M005514
GH19F005351 0.6 ENCODE 11 -103.2 -103201 1.1 BCOR GTF2F1 DRAP1 TBP PKNOX1 GTF2E2 NFRKB ZNF76 ZMYM3 KLF17 SH3GL1 ENSG00000267255 ZNRF4 VMAC RPL36 ENSG00000267571 SAFB2 PTPRS GC19P005411
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ZNRF4 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNRF4 Gene

Chromosome:
19
Start:
5,455,415 bp from pter
End:
5,456,856 bp from pter
Size:
1,442 bases
Orientation:
Plus strand

Genomic View for ZNRF4 Gene

Genes around ZNRF4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNRF4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNRF4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNRF4 Gene

Proteins for ZNRF4 Gene

  • Protein details for ZNRF4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WWF5-ZNRF4_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase ZNRF4
    Protein Accession:
    Q8WWF5
    Secondary Accessions:
    • A8K886
    • O75866

    Protein attributes for ZNRF4 Gene

    Size:
    429 amino acids
    Molecular mass:
    46958 Da
    Quaternary structure:
    • Interacts with CANX.
    SequenceCaution:
    • Sequence=AAC62428.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for ZNRF4 Gene

Post-translational modifications for ZNRF4 Gene

  • Glycosylation at Asn 107, Asn 152, and Asn 229
  • Modification sites at PhosphoSitePlus

Other Protein References for ZNRF4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNRF4 Gene

Domains & Families for ZNRF4 Gene

Gene Families for ZNRF4 Gene

Protein Domains for ZNRF4 Gene

Suggested Antigen Peptide Sequences for ZNRF4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8WWF5

UniProtKB/Swiss-Prot:

ZNRF4_HUMAN :
  • The RING-type zinc finger is involved in CANX ubiquitination and degradation, but is not required for interaction with CANX.
  • Contains 1 RING-type zinc finger.
Domain:
  • The RING-type zinc finger is involved in CANX ubiquitination and degradation, but is not required for interaction with CANX.
  • Contains 1 PA (protease associated) domain.
Similarity:
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with ZNRF4: view

Function for ZNRF4 Gene

Molecular function for ZNRF4 Gene

UniProtKB/Swiss-Prot Function:
E3 ubiquitin-protein ligase which specifically induces ubiquitination and proteasomal degradation of CANX within the endoplasmic reticulum (PubMed:21205830). Could have a role in spermatogenesis (By similarity).

Enzyme Numbers (IUBMB) for ZNRF4 Gene

Gene Ontology (GO) - Molecular Function for ZNRF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21205830
GO:0008270 zinc ion binding IEA --
GO:0016874 ligase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNRF4: view
genes like me logo Genes that share phenotypes with ZNRF4: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZNRF4 Gene

Localization for ZNRF4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNRF4 Gene

Endoplasmic reticulum membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNRF4 Gene COMPARTMENTS Subcellular localization image for ZNRF4 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 3

Gene Ontology (GO) - Cellular Components for ZNRF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane IEA,IDA 21205830
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ZNRF4: view

Pathways & Interactions for ZNRF4 Gene

SuperPathways for ZNRF4 Gene

No Data Available

UniProtKB/Swiss-Prot Q8WWF5-ZNRF4_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for ZNRF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process IDA 21205830
genes like me logo Genes that share ontologies with ZNRF4: view

No data available for Pathways by source and SIGNOR curated interactions for ZNRF4 Gene

Transcripts for ZNRF4 Gene

mRNA/cDNA for ZNRF4 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(24) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNRF4 Gene

Zinc and ring finger 4:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNRF4 Gene

No ASD Table

Relevant External Links for ZNRF4 Gene

GeneLoc Exon Structure for
ZNRF4
ECgene alternative splicing isoforms for
ZNRF4

Expression for ZNRF4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNRF4 Gene

mRNA differential expression in normal tissues according to GTEx for ZNRF4 Gene

This gene is overexpressed in Testis (x52.2).

NURSA nuclear receptor signaling pathways regulating expression of ZNRF4 Gene:

ZNRF4

SOURCE GeneReport for Unigene cluster for ZNRF4 Gene:

Hs.126496
genes like me logo Genes that share expression patterns with ZNRF4: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for ZNRF4 Gene

Orthologs for ZNRF4 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNRF4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNRF4 34 35
  • 97.38 (n)
dog
(Canis familiaris)
Mammalia ZNRF4 34 35
  • 81.83 (n)
cow
(Bos Taurus)
Mammalia ZNRF4 34 35
  • 75.78 (n)
mouse
(Mus musculus)
Mammalia Znrf4 34 16 35
  • 67.91 (n)
rat
(Rattus norvegicus)
Mammalia Znrf4 34
  • 65.71 (n)
oppossum
(Monodelphis domestica)
Mammalia ZNRF4 35
  • 54 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZNRF4 35
  • 41 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZNRF4 35
  • 37 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG10277 35
  • 18 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C18B12.4 35
  • 15 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.598 35
  • 23 (a)
OneToMany
Species where no ortholog for ZNRF4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for ZNRF4 Gene

ENSEMBL:
Gene Tree for ZNRF4 (if available)
TreeFam:
Gene Tree for ZNRF4 (if available)

Paralogs for ZNRF4 Gene

(2) SIMAP similar genes for ZNRF4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ZNRF4: view

Variants for ZNRF4 Gene

Sequence variations from dbSNP and Humsavar for ZNRF4 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1055022 -- 5,456,640(+) CCCAT(C/T)TGGGC reference, synonymous-codon
rs1055023 -- 5,456,786(+) AAGAT(C/G/T)TAGGG utr-variant-3-prime
rs112495393 -- 5,454,300(+) GAGGG(A/T)ACAGC upstream-variant-2KB
rs112960662 -- 5,455,814(+) CAACT(C/T)GAGCT reference, missense
rs113345491 -- 5,456,242(+) ACCCC(A/G)TGCTG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for ZNRF4 Gene

Variant ID Type Subtype PubMed ID
esv3643526 CNV gain 21293372
nsv1055783 CNV gain 25217958
nsv470118 CNV loss 18288195
nsv510751 CNV deletion 20534489
nsv516923 CNV loss 19592680
nsv833726 CNV loss 17160897

Variation tolerance for ZNRF4 Gene

Residual Variation Intolerance Score: 96.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.78; 93.36% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNRF4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNRF4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNRF4 Gene

Disorders for ZNRF4 Gene

Relevant External Links for ZNRF4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNRF4

No disorders were found for ZNRF4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNRF4 Gene

Publications for ZNRF4 Gene

  1. A systematic search for endoplasmic reticulum (ER) membrane-associated RING finger proteins identifies Nixin/ZNRF4 as a regulator of calnexin stability and ER homeostasis. (PMID: 21205830) Neutzner A. … Karbowski M. (J. Biol. Chem. 2011) 2 3 4 64
  2. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Sperizin is a murine RING zinc-finger protein specifically expressed in Haploid germ cells. (PMID: 10191088) Fujii T. … Abiko Y. (Genomics 1999) 2 3 64
  5. A comprehensive framework of E2-RING E3 interactions of the human ubiquitin-proteasome system. (PMID: 19690564) van Wijk S.J. … Timmers H.T. (Mol. Syst. Biol. 2009) 3 64

Products for ZNRF4 Gene

Sources for ZNRF4 Gene

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