ZNRF3 Gene
protein-coding GIFtS: 46
GCID: GC22P029279
|
|
zinc and ring finger 3
| |
Aliases
for ZNRF3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc And Ring Finger 31 2 | | RING Finger Protein 2032 3 | | RNF2031 2 3 | | FLJ220571 | | KIAA11331 3 5 | | E3 Ubiquitin-Protein Ligase ZNRF32 | | BK747E2.31 2 | | Novel C3HC4 Type Zinc Finger (Ring Finger)2 | | Zinc/RING Finger Protein 32 3 | | EC 6.3.2.-3 |
Export aliases for ZNRF3 gene to outside databasesPrevious GC identifers: GC22P027605 GC22P012347 |
Summaries
for ZNRF3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: ZNRF3_HUMAN, Q9ULT6Function: E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating theubiquitination and subsequent degradation of Wnt receptor complex components Frizzled and LRP6. Acts on both canonicaland non-canonical Wnt signaling pathway. Acts as a tumor suppressor in the intestinal stem cell zone by inhibiting theWnt signaling pathway, thereby resticting the size of the intestinal stem cell zone
|
Genomic Views
for ZNRF3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000022.10 NC_018933.1 NT_011520.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZNRF3 gene promoter:
RORalpha1 AML1a p300 c-Myb HNF-3beta Evi-1 FOXL1
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZNRF3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNRF3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 22q12.1 Ensembl cytogenetic band: 22q12.1 HGNC cytogenetic band: 22q12.1ZNRF3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 22 GeneLoc Exon Structure GeneLoc location for GC22P029279: view genomic region
(about GC identifiers)
Start:
|
29,279,580 bp from pter |
End:
|
29,453,475 bp from pter |
Size:
|
173,896 bases |
Orientation:
|
plus strand |
|
Proteins
for ZNRF3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZNRF3_HUMAN, Q9ULT6 (See
protein sequence)Recommended Name: E3 ubiquitin-protein ligase ZNRF3 precursor Size: 936 amino acids; 100574 Da
Subunit: Interacts with LRP6, FZD4, FZD5, FZD6 and FZD8. Interacts with RSPO1; interaction promotes indirectinteraction with LGR4 and membrane clearance of ZNRF3
Subcellular location: Cell membrane; Single-pass type I membrane protein
Sequence caution: Sequence=CAG30283.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: B3KU18 Q6ICH1 Q6NTF8 Q8WU18Alternative splicing: 2 isoforms: Q9ULT6-1 Q9ULT6-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for ZNRF3: NX_Q9ULT6
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9ULT6
ZNRF3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001193927.1 NP_115549.2
ENSEMBL proteins: ENSP00000443824 ENSP00000384456 ENSP00000384553 ENSP00000328614
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005887 | integral to plasma membrane |
IDA | -- |
ZNRF3 for ontologies About GeneDecksing
ZNRF3 Antibody Products:
Assay Products for ZNRF3: |
Protein
Domains /
Families
for ZNRF3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZNRF3 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9ULT6ProtoNet protein and cluster: Q9ULT6 1 Blocks protein family: IPB001841 Zn-finger
UniProtKB/Swiss-Prot: ZNRF3_HUMAN, Q9ULT6Similarity: Belongs to the ZNRF3 familySimilarity: Contains 1 RING-type zinc finger |
Function
for ZNRF3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ZNRF3_HUMAN, Q9ULT6Function: E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating theubiquitination and subsequent degradation of Wnt receptor complex components Frizzled and LRP6. Acts on both canonicaland non-canonical Wnt signaling pathway. Acts as a tumor suppressor in the intestinal stem cell zone by inhibiting theWnt signaling pathway, thereby resticting the size of the intestinal stem cell zoneEnzyme regulation: Negatively regulated by R-spondin proteins such as RSPO1: interaction with RSPO1 induces theindirect association between ZNRF3 and LGR4, promoting membrane clearance of ZNRF3Enzyme Number (IUBMB): EC 6.3.2.-1
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNRF3 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNRF3 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNRF3 |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
ZNRF3 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for ZNRF3:
Animal Models:
8 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Znrf3):
ZNRF3 for phenotypes About GeneDecksing
|
Pathways & Interactions
for ZNRF3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
UniProtKB/Swiss-Prot: ZNRF3_HUMAN, Q9ULT6Pathway: Protein modification; protein ubiquitinationInteractions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNRF3
STRING Interaction
Network Preview (showing 5 interactants - click image to see 6)
5/6 Interacting proteins for ZNRF3 (Q9ULT62, 3 ENSP000003286144) via UniProtKB, MINT, STRING, and/or I2D (see all 6) About this table
Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006511 | ubiquitin-dependent protein catabolic process |
IMP | -- | | GO:0016055 | Wnt receptor signaling pathway |
-- | -- | | GO:0016567 | protein ubiquitination |
IDA | -- | | GO:0038018 | Wnt receptor catabolic process |
IMP | -- | | GO:0060070 | canonical Wnt receptor signaling pathway |
IEA | -- |
ZNRF3 for ontologies About GeneDecksing
|
Drugs & Compounds
for ZNRF3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZNRF3
Search CenterWatch for drugs/clinical trials and news about ZNRF3
|
Transcripts
for ZNRF3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZNRF3 gene (2 alternative transcripts): NM_001206998.1 NM_032173.3 Unigene Clusters for ZNRF3: Zinc and ring finger 3 Hs.655242 [show with all ESTs], Hs.732114 [show with all ESTs]Unigene Representative Sequences: BC051344, NM_0012069984 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000544604(uc003aeg.3) ENST00000402174 ENST00000406323 ENST00000332811(uc021wnq.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNRF3 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNRF3 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ZNRF3 (NM_032173) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNRF3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNRF3 |
Additional cDNA sequence: AB051436.1 AK025710.1 AK096397.1 BC009252.2 BC021570.1 BC069019.1 BC094857.1 CR456397.1 12 DOTS entries: DT.113170 DT.100024055 DT.99965422 DT.40125202 DT.307120 DT.100785869 DT.120666714 DT.100696155 DT.100698221 DT.40266309 DT.91651955 DT.40237079 24/119 AceView cDNA sequences (see all 119): AB051436 CR619005 AI261282 BU182349 AI334264 BX367430 AI313369 BF510499 CR596794 CR613419 BC021570 CR456397 AI470184 BX485769 AA719532 BE467307 T33532 AA776466 D30866 BX354381 F08245 AK025710 BG826524 BX430900
GeneLoc Exon Structure
|
Expression
for ZNRF3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZNRF3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See ZNRF3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZNRF3
SOURCE GeneReport for Unigene clusters: Hs.655242 Hs.732114
SABiosciences Custom PCR Arrays for ZNRF3
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNRF3
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ZNRF3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNRF3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNRF3 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNRF3 |
Orthologs
for ZNRF3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for ZNRF3 gene from 5/15 species (see all 15) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
ZNRF31 |
zinc and ring finger 3 |
73.32(n)
74.7(a) |
|
416919 XM_415210.3 XP_415210.3 |
tropical clawed frog
(Xenopus tropicalis) |
Amphibia |
AL849420.22 |
-- |
80(n) |
|
AL849420.2 |
zebrafish
(Danio rerio) |
Actinopterygii |
znrf31 |
E3 ubiquitin-protein ligase ZNRF3 |
64.03(n)
67.15(a) |
|
556813 XM_679715.5 XP_684807.5 |
worm
(Caenorhabditis elegans) |
Secernentea |
Y47D3B.116 |
Protein Y47D3B.11 |
17(a) |
1 → many |
III(11456777-11462782) |
rice
(Oryza sativa) |
Liliopsida |
-- |
zinc finger, C3HC4 type domain containing protein |
40(a) |
1 → many |
12(26391264-26391518) |
ENSEMBL Gene Tree for ZNRF3 (if available)
TreeFam Gene Tree for ZNRF3 (if available) |
Paralogs
for ZNRF3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ZNRF3 gene
- RNF1482 RNF432 RNF1492 RNF1332 RNF1502 RNF1302 RNF1672 RNF2152
- RNF1282 ZNRF42 RNF132
ZNRF3 for paralogs About GeneDecksing
|
Genomic Variants
for ZNRF3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 22 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZNRF3 (29279580 - 29453475 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for ZNRF3
1 CNV: 67862 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNRF3 |
|
Disorders
/ Diseases
for ZNRF3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ZNRF3 for disorders About GeneDecksing
OMIM gene information: 612062
OMIM disorders: --
1  disease for ZNRF3: About MalaCardsataxia
Human Genome Epidemiology (HuGE) Navigator: ZNRF3 (4 documents)
Export disorders for ZNRF3 gene to outside databases
|
Publications
for ZNRF3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZNRF3 gene, integrated from 9 sources (see all 14):
(articles sorted by number of sources associating them with ZNRF3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. (PubMed id 10574461)1, 2, 3 Hirosawa M.... Ohara O. (1999)
- ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner. (PubMed id 22575959)1, 2 Hao H.X....Cong F. (2012)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (2004)
- Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)1, 2 Nakajima D.... Nagase T. (2002)
- The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 2 Dunham I....O'Brien K.P. (1999)
- Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distr ibution. (PubMed id 20935629)1 Heid I.M....Lindgren C.M. (2010)
- Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1 Bailey S.D....Anand S. (2010)
- Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)
|
External Searches for ZNRF3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZNRF3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZNRF3 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing ZNRF3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZNRF3 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZNRF3 gene:
Search GeneIP for patents involving ZNRF3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZNRF3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNRF3 |
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