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Aliases for ZNRF3 Gene

Aliases for ZNRF3 Gene

  • Zinc And Ring Finger 3 2 3
  • Zinc/RING Finger Protein 3 3 4
  • RING Finger Protein 203 3 4
  • KIAA1133 4 6
  • RNF203 3 4
  • Novel C3HC4 Type Zinc Finger (Ring Finger) 3
  • E3 Ubiquitin-Protein Ligase ZNRF3 3
  • CTA-292E10.6 3
  • EC 6.3.2.- 4
  • BK747E2.3 3

External Ids for ZNRF3 Gene

Previous GeneCards Identifiers for ZNRF3 Gene

  • GC22P027605
  • GC22P029279
  • GC22P012347

Summaries for ZNRF3 Gene

GeneCards Summary for ZNRF3 Gene

ZNRF3 (Zinc And Ring Finger 3) is a Protein Coding gene. GO annotations related to this gene include ubiquitin-protein transferase activity and frizzled binding. An important paralog of this gene is RNF167.

UniProtKB/Swiss-Prot for ZNRF3 Gene

  • E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components Frizzled and LRP6. Acts on both canonical and non-canonical Wnt signaling pathway. Acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway, thereby resticting the size of the intestinal stem cell zone.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNRF3 Gene

Genomics for ZNRF3 Gene

Regulatory Elements for ZNRF3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ZNRF3 Gene

Start:
28,883,592 bp from pter
End:
29,057,488 bp from pter
Size:
173,897 bases
Orientation:
Plus strand

Genomic View for ZNRF3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNRF3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNRF3 Gene

Proteins for ZNRF3 Gene

  • Protein details for ZNRF3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9ULT6-ZNRF3_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase ZNRF3
    Protein Accession:
    Q9ULT6
    Secondary Accessions:
    • B3KU18
    • Q6ICH1
    • Q6NTF8
    • Q8WU18

    Protein attributes for ZNRF3 Gene

    Size:
    936 amino acids
    Molecular mass:
    100574 Da
    Quaternary structure:
    • Interacts with LRP6, FZD4, FZD5, FZD6 and FZD8. Interacts with RSPO1; interaction promotes indirect interaction with LGR4 and membrane clearance of ZNRF3.
    SequenceCaution:
    • Sequence=CAG30283.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNRF3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNRF3 Gene

Proteomics data for ZNRF3 Gene at MOPED

Post-translational modifications for ZNRF3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNRF3 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNRF3 Gene

Domains for ZNRF3 Gene

Gene Families for ZNRF3 Gene

HGNC:
  • RNF :RING-type (C3HC4) zinc fingers

Protein Domains for ZNRF3 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for ZNRF3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9ULT6

UniProtKB/Swiss-Prot:

ZNRF3_HUMAN :
  • Q9ULT6
Family:
  • Belongs to the ZNRF3 family.
Similarity:
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with ZNRF3: view

Function for ZNRF3 Gene

Molecular function for ZNRF3 Gene

UniProtKB/Swiss-Prot EnzymeRegulation: Negatively regulated by R-spondin proteins such as RSPO1: interaction with RSPO1 induces the indirect association between ZNRF3 and LGR4, promoting membrane clearance of ZNRF3.
UniProtKB/Swiss-Prot Function: E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components Frizzled and LRP6. Acts on both canonical and non-canonical Wnt signaling pathway. Acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway, thereby resticting the size of the intestinal stem cell zone.

Enzyme Numbers (IUBMB) for ZNRF3 Gene

Gene Ontology (GO) - Molecular Function for ZNRF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IDA 22575959
GO:0005109 frizzled binding IPI 22575959
GO:0005515 protein binding IPI 22575959
GO:0008270 zinc ion binding IEA --
GO:0016874 ligase activity IEA --
genes like me logo Genes that share ontologies with ZNRF3: view
genes like me logo Genes that share phenotypes with ZNRF3: view

Animal Model Products

CRISPR Products

miRNA for ZNRF3 Gene

miRTarBase miRNAs that target ZNRF3

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNRF3

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for ZNRF3 Gene

Localization for ZNRF3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNRF3 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNRF3 Gene COMPARTMENTS Subcellular localization image for ZNRF3 gene
Compartment Confidence
plasma membrane 5
cytosol 1
endoplasmic reticulum 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for ZNRF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IDA 22575959
genes like me logo Genes that share ontologies with ZNRF3: view

Pathways for ZNRF3 Gene

SuperPathways for ZNRF3 Gene

No Data Available

UniProtKB/Swiss-Prot Q9ULT6-ZNRF3_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for ZNRF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006511 ubiquitin-dependent protein catabolic process IMP 22575959
GO:0016567 protein ubiquitination IEA --
GO:0030178 negative regulation of Wnt signaling pathway --
GO:0038018 Wnt receptor catabolic process IMP 22575959
GO:0060070 canonical Wnt signaling pathway IEA --
genes like me logo Genes that share ontologies with ZNRF3: view

No data available for Pathways by source for ZNRF3 Gene

Transcripts for ZNRF3 Gene

Unigene Clusters for ZNRF3 Gene

Zinc and ring finger 3:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNRF3

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNRF3 Gene

No ASD Table

Relevant External Links for ZNRF3 Gene

GeneLoc Exon Structure for
ZNRF3
ECgene alternative splicing isoforms for
ZNRF3

Expression for ZNRF3 Gene

mRNA expression in normal human tissues for ZNRF3 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ZNRF3 Gene

SOURCE GeneReport for Unigene cluster for ZNRF3 Gene Hs.655242

genes like me logo Genes that share expressions with ZNRF3: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNRF3 Gene

Orthologs for ZNRF3 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNRF3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNRF3 35
  • 99.28 (n)
  • 99.4 (a)
ZNRF3 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZNRF3 36
  • 72 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZNRF3 35
  • 90.1 (n)
  • 90.18 (a)
ZNRF3 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Znrf3 35
  • 86.26 (n)
  • 87.35 (a)
Znrf3 16
Znrf3 36
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZNRF3 36
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZNRF3 36
  • 73 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Znrf3 35
  • 81.1 (n)
  • 80.38 (a)
chicken
(Gallus gallus)
Aves ZNRF3 35
  • 73.11 (n)
  • 74.33 (a)
ZNRF3 36
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia znrf3 35
  • 65.1 (n)
  • 68.8 (a)
zebrafish
(Danio rerio)
Actinopterygii znrf3 35
  • 64.83 (n)
  • 67.73 (a)
znrf3 36
  • 62 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea Y47D3B.11 36
  • 22 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8714 36
  • 32 (a)
OneToMany
Species with no ortholog for ZNRF3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZNRF3 Gene

ENSEMBL:
Gene Tree for ZNRF3 (if available)
TreeFam:
Gene Tree for ZNRF3 (if available)

Paralogs for ZNRF3 Gene

genes like me logo Genes that share paralogs with ZNRF3: view

Variants for ZNRF3 Gene

Sequence variations from dbSNP and Humsavar for ZNRF3 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs4055 -- 28,956,507(+) TGGAG(A/C)AGCTA intron-variant
rs12321 -- 29,057,205(+) ATTCT(C/G)TATAT utr-variant-3-prime
rs132527 -- 28,898,519(+) GACTT(C/T)TGGGG intron-variant
rs132528 -- 28,899,910(+) AGTCT(C/T)GAACT intron-variant
rs132529 -- 28,900,664(+) ACACA(A/G)AAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNRF3 Gene

Variant ID Type Subtype PubMed ID
nsv834169 CNV Loss 17160897
nsv3589 CNV Loss 18451855
esv2657238 CNV Deletion 23128226
esv26777 CNV Loss 19812545

Relevant External Links for ZNRF3 Gene

HapMap Linkage Disequilibrium report
ZNRF3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNRF3 Gene

Disorders for ZNRF3 Gene

Relevant External Links for ZNRF3

Genetic Association Database (GAD)
ZNRF3
Human Genome Epidemiology (HuGE) Navigator
ZNRF3
genes like me logo Genes that share disorders with ZNRF3: view

No data available for UniProtKB/Swiss-Prot for ZNRF3 Gene

Publications for ZNRF3 Gene

  1. Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. (PMID: 10574461) Hirosawa M. … Ohara O. (DNA Res. 1999) 2 3 4
  2. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I. … Wright H. (Nature 1999) 3 4
  3. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PMID: 12168954) Nakajima D. … Nagase T. (DNA Res. 2002) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. A genome annotation-driven approach to cloning the human ORFeome. (PMID: 15461802) Collins J.E. … Dunham I. (Genome Biol. 2004) 3 4

Products for ZNRF3 Gene

Sources for ZNRF3 Gene

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