Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ZNRF2 Gene

Aliases for ZNRF2 Gene

  • Zinc And Ring Finger 2 2 3 5
  • Zinc And Ring Finger 2, E3 Ubiquitin Protein Ligase 2 3
  • RING-Type E3 Ubiquitin Transferase ZNRF2 3 4
  • Zinc/RING Finger Protein 2 3 4
  • RING Finger Protein 202 3 4
  • Protein Ells2 3 4
  • RNF202 3 4
  • E3 Ubiquitin-Protein Ligase ZNRF2 3
  • Zinc Finger/RING Finger 2 3
  • EC 4

External Ids for ZNRF2 Gene

Previous GeneCards Identifiers for ZNRF2 Gene

  • GC07P030068
  • GC07P030097
  • GC07P030290

Summaries for ZNRF2 Gene

GeneCards Summary for ZNRF2 Gene

ZNRF2 (Zinc And Ring Finger 2) is a Protein Coding gene. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. Gene Ontology (GO) annotations related to this gene include ligase activity and ubiquitin protein ligase activity. An important paralog of this gene is ZNRF1.

UniProtKB/Swiss-Prot for ZNRF2 Gene

  • May play a role in the establishment and maintenance of neuronal transmission and plasticity via its ubiquitin ligase activity. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.

Additional gene information for ZNRF2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNRF2 Gene

Genomics for ZNRF2 Gene

GeneHancer (GH) Regulatory Elements for ZNRF2 Gene

Promoters and enhancers for ZNRF2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07I030283 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 550.8 +1.5 1450 4.7 HDGF PKNOX1 CLOCK MLX ARNT ARID4B SIN3A DMAP1 YY1 ZNF766 ZNRF2 GC07P030289
GH07I030161 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 21.8 -119.8 -119751 5.4 PKNOX1 ARID4B FEZF1 YY1 TCF12 ZNF143 RUNX3 RXRA SP5 REST ZNRF2 MIR550A1 NOD1 MTURN LOC105375217 RPS27P16 ENSG00000251660
GH07I030168 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 20.4 -113.1 -113055 6.4 PKNOX1 INSM2 SIN3A FEZF1 RAD21 ZNF335 RCOR1 FOS ZNF654 CEBPB GC07P030172 ZNRF2 MIR550A1 NOD1 MTURN LOC105375217 RPS27P16
GH07I030347 Enhancer 1.4 FANTOM5 Ensembl ENCODE 16.6 +64.3 64334 3.2 PKNOX1 ATF1 SMAD1 NEUROD1 FEZF1 ZNF766 ZNF207 ATF7 FOS RUNX3 ZNRF2 MIR550A1 NOD1 GC07P030343 ENSG00000281593
GH07I030158 Enhancer 1.2 Ensembl ENCODE dbSUPER 12.1 -124.4 -124420 2 SOX13 CTCF ESRRA KLF1 FOXA2 MAX ZNF48 RAD21 RARA CTBP1 MIR550A1 ZNRF2 NOD1 MTURN LOC105375217 ENSG00000251660 RPS27P16
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNRF2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNRF2 gene promoter:

Genomic Locations for ZNRF2 Gene

Genomic Locations for ZNRF2 Gene
83,386 bases
Plus strand

Genomic View for ZNRF2 Gene

Genes around ZNRF2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNRF2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNRF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNRF2 Gene

Proteins for ZNRF2 Gene

  • Protein details for ZNRF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    E3 ubiquitin-protein ligase ZNRF2
    Protein Accession:

    Protein attributes for ZNRF2 Gene

    242 amino acids
    Molecular mass:
    24115 Da
    Quaternary structure:
    • Interacts with UBE2N.

neXtProt entry for ZNRF2 Gene

Post-translational modifications for ZNRF2 Gene

  • Ubiquitination at isoforms=165 and isoforms=182

Other Protein References for ZNRF2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNRF2 Gene

Domains & Families for ZNRF2 Gene

Gene Families for ZNRF2 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for ZNRF2 Gene

Suggested Antigen Peptide Sequences for ZNRF2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • The RING-type zinc finger domain is required for E3 ligase activity.
  • The RING-type zinc finger domain is required for E3 ligase activity.
genes like me logo Genes that share domains with ZNRF2: view

Function for ZNRF2 Gene

Molecular function for ZNRF2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.
UniProtKB/Swiss-Prot Function:
May play a role in the establishment and maintenance of neuronal transmission and plasticity via its ubiquitin ligase activity. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.

Enzyme Numbers (IUBMB) for ZNRF2 Gene

Gene Ontology (GO) - Molecular Function for ZNRF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity TAS --
GO:0016740 transferase activity IEA --
GO:0046872 metal ion binding IEA --
GO:0061630 ubiquitin protein ligase activity IDA 22797923
genes like me logo Genes that share ontologies with ZNRF2: view
genes like me logo Genes that share phenotypes with ZNRF2: view

miRNA for ZNRF2 Gene

miRTarBase miRNAs that target ZNRF2

Clone Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNRF2 Gene

Localization for ZNRF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNRF2 Gene

Endosome membrane; Peripheral membrane protein. Lysosome membrane; Peripheral membrane protein. Cell junction, synapse, presynaptic cell membrane; Peripheral membrane protein. Note=Present in presynaptic plasma membranes in neurons.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNRF2 gene
Compartment Confidence
plasma membrane 5
cytosol 5
lysosome 3
endosome 3
extracellular 2
mitochondrion 1
peroxisome 1
nucleus 1

Gene Ontology (GO) - Cellular Components for ZNRF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 22797923
GO:0005764 lysosome IEA --
GO:0005765 lysosomal membrane IEA --
GO:0005768 endosome IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with ZNRF2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ZNRF2 Gene

Pathways & Interactions for ZNRF2 Gene

genes like me logo Genes that share pathways with ZNRF2: view

UniProtKB/Swiss-Prot Q8NHG8-ZNRF2_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for ZNRF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000209 protein polyubiquitination TAS --
GO:0016567 protein ubiquitination IEA --
GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process IBA --
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IBA --
genes like me logo Genes that share ontologies with ZNRF2: view

No data available for SIGNOR curated interactions for ZNRF2 Gene

Drugs & Compounds for ZNRF2 Gene

(3) Drugs for ZNRF2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Adenosine monophosphate Approved, Investigational Nutra 0
ATP Investigational Nutra Agonist 0

(1) Additional Compounds for ZNRF2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • (4-)Diphosphoric acid ion
  • (P2O74-)Diphosphate
  • Diphosphate
  • Diphosphoric acid
  • PPi
genes like me logo Genes that share compounds with ZNRF2: view

Transcripts for ZNRF2 Gene

mRNA/cDNA for ZNRF2 Gene

Unigene Clusters for ZNRF2 Gene

Zinc and ring finger 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNRF2 Gene

No ASD Table

Relevant External Links for ZNRF2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNRF2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNRF2 Gene

Protein differential expression in normal tissues from HIPED for ZNRF2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (9.8), Stomach (9.2), Testis (8.8), and Ovary (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZNRF2 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNRF2 Gene:


SOURCE GeneReport for Unigene cluster for ZNRF2 Gene:


mRNA Expression by UniProt/SwissProt for ZNRF2 Gene:

Tissue specificity: Highly expressed in the brain, with higher expression during development than in adult. Expressed also in mammary glands, testis, colon and kidney.

Evidence on tissue expression from TISSUES for ZNRF2 Gene

  • Liver(4.3)
genes like me logo Genes that share expression patterns with ZNRF2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNRF2 Gene

Orthologs for ZNRF2 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNRF2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNRF2 33 34
  • 97.88 (n)
(Bos Taurus)
Mammalia ZNRF2 33 34
  • 92.09 (n)
(Mus musculus)
Mammalia Znrf2 33 16 34
  • 84.84 (n)
(Rattus norvegicus)
Mammalia Znrf2 33
  • 83.91 (n)
(Monodelphis domestica)
Mammalia ZNRF2 34
  • 71 (a)
(Gallus gallus)
Aves ZNRF2 33 34
  • 88.06 (n)
(Anolis carolinensis)
Reptilia ZNRF2 34
  • 70 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia znrf2 33
  • 75.49 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.12475 33
(Danio rerio)
Actinopterygii znrf2b 33 34
  • 66.83 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5607 33
fruit fly
(Drosophila melanogaster)
Insecta CG14435 34
  • 33 (a)
(Caenorhabditis elegans)
Secernentea Y71F9AL.10 34
  • 40 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3182 34
  • 36 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.13301 33
Species where no ortholog for ZNRF2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZNRF2 Gene

Gene Tree for ZNRF2 (if available)
Gene Tree for ZNRF2 (if available)

Paralogs for ZNRF2 Gene

Paralogs for ZNRF2 Gene

(1) SIMAP similar genes for ZNRF2 Gene using alignment to 2 proteins: Pseudogenes for ZNRF2 Gene

genes like me logo Genes that share paralogs with ZNRF2: view

Variants for ZNRF2 Gene

Sequence variations from dbSNP and Humsavar for ZNRF2 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000044239 -- 30,304,966(+) T/C intron_variant
rs1000069194 -- 30,338,993(+) G/A genic_downstream_transcript_variant, intron_variant
rs1000113953 -- 30,283,481(+) G/A upstream_transcript_variant
rs1000143331 -- 30,352,421(+) C/T genic_downstream_transcript_variant, intron_variant
rs1000198576 -- 30,364,549(+) T/G genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNRF2 Gene

Variant ID Type Subtype PubMed ID
nsv1019527 CNV gain 25217958
nsv1068321 OTHER inversion 25765185
nsv1074493 CNV deletion 25765185
nsv1144169 CNV deletion 24896259
nsv1148830 OTHER inversion 26484159
nsv436557 CNV deletion 17901297
nsv523514 CNV gain 19592680
nsv525379 CNV loss 19592680
nsv970455 CNV duplication 23825009
nsv981445 CNV duplication 23825009

Variation tolerance for ZNRF2 Gene

Gene Damage Index Score: 4.08; 60.95% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNRF2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNRF2 Gene

Disorders for ZNRF2 Gene

Additional Disease Information for ZNRF2

No disorders were found for ZNRF2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNRF2 Gene

Publications for ZNRF2 Gene

  1. ZNRF proteins constitute a family of presynaptic E3 ubiquitin ligases. (PMID: 14561866) Araki T … Milbrandt J (The Journal of neuroscience : the official journal of the Society for Neuroscience 2003) 3 4 22 58
  2. ZNRF2 is released from membranes by growth factors and, together with ZNRF1, regulates the Na+/K+ATPase. (PMID: 22797923) Hoxhaj G … MacKintosh C (Journal of cell science 2012) 2 3 58
  3. The RING finger protein RNF8 recruits UBC13 for lysine 63-based self polyubiquitylation. (PMID: 16215985) Plans V … Thomson TM (Journal of cellular biochemistry 2006) 3 4 58
  4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for ZNRF2 Gene

Sources for ZNRF2 Gene

Loading form....