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Aliases for ZNRF2 Gene

Aliases for ZNRF2 Gene

  • Zinc And Ring Finger 2, E3 Ubiquitin Protein Ligase 2 3 5
  • Zinc/RING Finger Protein 2 3 4
  • RING Finger Protein 202 3 4
  • Protein Ells2 3 4
  • RNF202 3 4
  • Zinc Finger/RING Finger 2 3
  • Zinc And Ring Finger 2 2
  • EC 6.3.2.- 4

External Ids for ZNRF2 Gene

Previous GeneCards Identifiers for ZNRF2 Gene

  • GC07P030068
  • GC07P030097
  • GC07P030290

Summaries for ZNRF2 Gene

GeneCards Summary for ZNRF2 Gene

ZNRF2 (Zinc And Ring Finger 2, E3 Ubiquitin Protein Ligase) is a Protein Coding gene. Among its related pathways are Antigen processing- Ubiquitination and Proteasome degradation and Immune System. GO annotations related to this gene include ligase activity and ubiquitin protein ligase activity. An important paralog of this gene is ZNRF1.

UniProtKB/Swiss-Prot for ZNRF2 Gene

  • May play a role in the establishment and maintenance of neuronal transmission and plasticity via its ubiquitin ligase activity. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNRF2 Gene

Genomics for ZNRF2 Gene

Regulatory Elements for ZNRF2 Gene

Enhancers for ZNRF2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZNRF2 on UCSC Golden Path with GeneCards custom track

Promoters for ZNRF2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNRF2 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNRF2 Gene

Chromosome:
7
Start:
30,284,307 bp from pter
End:
30,367,692 bp from pter
Size:
83,386 bases
Orientation:
Plus strand

Genomic View for ZNRF2 Gene

Genes around ZNRF2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNRF2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNRF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNRF2 Gene

Proteins for ZNRF2 Gene

  • Protein details for ZNRF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NHG8-ZNRF2_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase ZNRF2
    Protein Accession:
    Q8NHG8

    Protein attributes for ZNRF2 Gene

    Size:
    242 amino acids
    Molecular mass:
    24115 Da
    Quaternary structure:
    • Interacts with UBE2N.

neXtProt entry for ZNRF2 Gene

Proteomics data for ZNRF2 Gene at MOPED

Post-translational modifications for ZNRF2 Gene

  • Ubiquitination at Lys 165 and Lys 182
  • Modification sites at PhosphoSitePlus

Other Protein References for ZNRF2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNRF2 Gene

Domains & Families for ZNRF2 Gene

Gene Families for ZNRF2 Gene

Protein Domains for ZNRF2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for ZNRF2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NHG8

UniProtKB/Swiss-Prot:

ZNRF2_HUMAN :
  • The RING-type zinc finger domain is required for E3 ligase activity.
  • Contains 1 RING-type zinc finger.
Domain:
  • The RING-type zinc finger domain is required for E3 ligase activity.
Similarity:
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with ZNRF2: view

Function for ZNRF2 Gene

Molecular function for ZNRF2 Gene

UniProtKB/Swiss-Prot Function:
May play a role in the establishment and maintenance of neuronal transmission and plasticity via its ubiquitin ligase activity. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.

Enzyme Numbers (IUBMB) for ZNRF2 Gene

Gene Ontology (GO) - Molecular Function for ZNRF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity TAS --
genes like me logo Genes that share ontologies with ZNRF2: view
genes like me logo Genes that share phenotypes with ZNRF2: view

Animal Model Products

miRNA for ZNRF2 Gene

miRTarBase miRNAs that target ZNRF2

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNRF2 Gene

Localization for ZNRF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNRF2 Gene

Endosome membrane; Peripheral membrane protein. Lysosome membrane; Peripheral membrane protein. Cell junction, synapse, presynaptic cell membrane; Peripheral membrane protein. Note=Present in presynaptic plasma membranes in neurons.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNRF2 Gene COMPARTMENTS Subcellular localization image for ZNRF2 gene
Compartment Confidence
plasma membrane 5
endosome 3
lysosome 3
vacuole 3
extracellular 2
cytosol 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for ZNRF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 22797923
GO:0005765 lysosomal membrane IEA --
GO:0005886 plasma membrane IDA 22797923
GO:0010008 endosome membrane IEA --
GO:0043234 protein complex IDA 22797923
genes like me logo Genes that share ontologies with ZNRF2: view

Pathways & Interactions for ZNRF2 Gene

genes like me logo Genes that share pathways with ZNRF2: view

UniProtKB/Swiss-Prot Q8NHG8-ZNRF2_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for ZNRF2 Gene

None

No data available for SIGNOR curated interactions for ZNRF2 Gene

Drugs & Compounds for ZNRF2 Gene

(3) Drugs for ZNRF2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine monophosphate Approved Nutra 0
Adenosine triphosphate Approved Nutra 0
Diphosphate Experimental Pharma 0

(1) Additional Compounds for ZNRF2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
genes like me logo Genes that share compounds with ZNRF2: view

Transcripts for ZNRF2 Gene

mRNA/cDNA for ZNRF2 Gene

Unigene Clusters for ZNRF2 Gene

Zinc and ring finger 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNRF2 Gene

No ASD Table

Relevant External Links for ZNRF2 Gene

GeneLoc Exon Structure for
ZNRF2
ECgene alternative splicing isoforms for
ZNRF2

Expression for ZNRF2 Gene

mRNA expression in normal human tissues for ZNRF2 Gene

Protein differential expression in normal tissues from HIPED for ZNRF2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (9.8), Stomach (9.2), Testis (8.8), and Ovary (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZNRF2 Gene



SOURCE GeneReport for Unigene cluster for ZNRF2 Gene Hs.263912

mRNA Expression by UniProt/SwissProt for ZNRF2 Gene

Q8NHG8-ZNRF2_HUMAN
Tissue specificity: Highly expressed in the brain, with higher expression during development than in adult. Expressed also in mammary glands, testis, colon and kidney.
genes like me logo Genes that share expression patterns with ZNRF2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein tissue co-expression partners for ZNRF2 Gene

Orthologs for ZNRF2 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNRF2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ZNRF2 35
  • 92.09 (n)
  • 92.37 (a)
ZNRF2 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Znrf2 35
  • 84.84 (n)
  • 84.12 (a)
Znrf2 16
Znrf2 36
  • 82 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ZNRF2 35
  • 97.88 (n)
  • 97.03 (a)
ZNRF2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Znrf2 35
  • 83.91 (n)
  • 84.91 (a)
oppossum
(Monodelphis domestica)
Mammalia ZNRF2 36
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZNRF2 35
  • 88.06 (n)
  • 94.78 (a)
ZNRF2 36
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZNRF2 36
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia znrf2 35
  • 75.49 (n)
  • 81.62 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.12475 35
zebrafish
(Danio rerio)
Actinopterygii znrf2b 35
  • 66.83 (n)
  • 71.29 (a)
znrf2b 36
  • 96 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5607 35
fruit fly
(Drosophila melanogaster)
Insecta CG14435 36
  • 33 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y71F9AL.10 36
  • 40 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.13301 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3182 36
  • 36 (a)
OneToMany
Species with no ortholog for ZNRF2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZNRF2 Gene

ENSEMBL:
Gene Tree for ZNRF2 (if available)
TreeFam:
Gene Tree for ZNRF2 (if available)

Paralogs for ZNRF2 Gene

Paralogs for ZNRF2 Gene

(1) SIMAP similar genes for ZNRF2 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for ZNRF2 Gene

genes like me logo Genes that share paralogs with ZNRF2: view

Variants for ZNRF2 Gene

Sequence variations from dbSNP and Humsavar for ZNRF2 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs6949098 -- 30,340,707(+) ttttt(G/T)ttgtt intron-variant
rs6959139 -- 30,321,216(+) GACCT(C/T)GGGAT intron-variant
rs6968097 -- 30,305,340(+) TCTTA(C/T)GTAAA intron-variant
rs1611046 -- 30,359,555(+) GAAAG(-/CA)TATAT intron-variant
rs6970041 -- 30,293,298(+) ggcta(C/G)agtgc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNRF2 Gene

Variant ID Type Subtype PubMed ID
nsv436557 CNV Deletion 17901297
nsv523514 CNV Gain 19592680
nsv525379 CNV Loss 19592680

Variation tolerance for ZNRF2 Gene

Gene Damage Index Score: 4.08; 60.95% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ZNRF2 Gene

Disorders for ZNRF2 Gene

Relevant External Links for ZNRF2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNRF2

No disorders were found for ZNRF2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNRF2 Gene

Publications for ZNRF2 Gene

  1. ZNRF proteins constitute a family of presynaptic E3 ubiquitin ligases. (PMID: 14561866) Araki T. … Milbrandt J. (J. Neurosci. 2003) 3 4 23 67
  2. ZNRF2 is released from membranes by growth factors and, together with ZNRF1, regulates the Na+/K+ATPase. (PMID: 22797923) Hoxhaj G. … MacKintosh C. (J. Cell. Sci. 2012) 2 3
  3. A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning. (PMID: 26673895) KA+rlA+ K. … GAPrlich D. (Elife 2015) 3
  4. Identifying biological pathways that underlie primordial short stature using network analysis. (PMID: 24711643) Hanson D. … Clayton P.E. (J. Mol. Endocrinol. 2014) 3
  5. 14-3-3 proteins sequester a pool of soluble TRIM32 ubiquitin ligase to repress autoubiquitylation and cytoplasmic body formation. (PMID: 23444366) Ichimura T. … Hachiya N. (J. Cell. Sci. 2013) 3

Products for ZNRF2 Gene

Sources for ZNRF2 Gene

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