Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZNRF2 Gene

protein-coding   GIFtS: 49
GCID: GC07P030290

zinc and ring finger 2
 Explore 1 disease affiliated with
ZNRF2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for ZNRF2    

Aliases
for ZNRF2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Zinc And Ring Finger 21 2     RING Finger Protein 2022 3
RNF2021 2 3     E3 Ubiquitin-Protein Ligase ZNRF22
Protein Ells22 3     Zinc Finger/RING Finger 22
Zinc/RING Finger Protein 22 3     EC 6.3.2.-3

External Ids:    HGNC: 223161   Entrez Gene: 2230822   Ensembl: ENSG000001802337   OMIM: 6120615   UniProtKB: Q8NHG83   

Export aliases for ZNRF2 gene to outside databases

Previous GC identifers: GC07P030068 GC07P030097


Summaries
for ZNRF2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: ZNRF2_HUMAN, Q8NHG8
Function: May play a role in the establishment and maintenance of neuronal transmission and plasticity via its
ubiquitin ligase activity. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form
of a thioester and then directly transfer the ubiquitin to targeted substrates




Genomic Views
for ZNRF2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.1  NT_007819.17  NT_079592.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZNRF2 gene promoter:
         GR   Pax-5   HSF1 (long)   RORalpha1   PPAR-gamma1   USF-1   HSF1short   PPAR-gamma2   GR-alpha   LyF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ZNRF2 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZNRF2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNRF2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p14.3   Ensembl cytogenetic band:  7p14.3   HGNC cytogenetic band: 7p15.1

ZNRF2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNRF2 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P030290:  view genomic region     (about GC identifiers)

Start:
 30,323,923 bp from pter      End:
 30,452,118 bp from pter
Size:
 128,196 bases      Orientation:
 plus strand

1 alternative location:
Chr7+,CRA_TCAG 30,373,689-30,457,078     

Proteins
for ZNRF2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: ZNRF2_HUMAN, Q8NHG8 (See protein sequence)
Recommended Name: E3 ubiquitin-protein ligase ZNRF2  
Size: 242 amino acids; 24115 Da
Subunit: Interacts with UBE2N
Subcellular location: Endosome membrane; Peripheral membrane protein. Lysosome membrane; Peripheral membrane protein.
Cell junction, synapse, presynaptic cell membrane; Peripheral membrane protein. Note=Present in presynaptic plasma
membranes in neurons

Explore the universe of human proteins at neXtProt for ZNRF2: NX_Q8NHG8

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q8NHG8

    • ZNRF2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_667339.1  
    ENSEMBL proteins: 
     ENSP00000323879   ENSP00000456371  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: ZNRF2
    OriGene Custom Protein Services for ZNRF2 
    GenScript Custom Purified and Recombinant Proteins Services for ZNRF2
    Novus Biologicals ZNRF2 Protein
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for ZNRF2

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005765lysosomal membrane IEA--
    GO:0005886plasma membrane IEA--
    GO:0010008endosome membrane IEA--
    GO:0030054cell junction IEA--
    GO:0042734presynaptic membrane IEA--


    ZNRF2 for ontologies           About GeneDecksing



    ZNRF2 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for ZNRF2 
    GenScript Custom Superior Antibodies Services for ZNRF2
    Novus Biologicals ZNRF2 Antibodies
    Abcam antibodies for ZNRF2 
    Uscn Antibodies for ZNRF2
    Search ThermoFisher Antibodies for ZNRF2

    Assay Products for ZNRF2: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ZNRF2
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for ZNRF2

    Protein Domains /
    Families
    for ZNRF2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ZNRF2 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR001841 Znf_RING
     IPR013083 Znf_RING/FYVE/PHD

    Graphical View of Domain Structure for InterPro Entry Q8NHG8

    ProtoNet protein and cluster: Q8NHG8

    1 Blocks protein family: IPB001841 Zn-finger

    UniProtKB/Swiss-Prot: ZNRF2_HUMAN, Q8NHG8
    Domain: The RING-type zinc finger domain is required for E3 ligase activity (By similarity)
    Similarity: Contains 1 RING-type zinc finger


    Function
    for ZNRF2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: ZNRF2_HUMAN, Q8NHG8
    Function: May play a role in the establishment and maintenance of neuronal transmission and plasticity via its
    ubiquitin ligase activity. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form
    of a thioester and then directly transfer the ubiquitin to targeted substrates

    Enzyme Number (IUBMB): EC 6.3.2.-1

    miRNA
    Products:            		 OriGene 3'-UTR Clone: ZNRF2
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ZNRF2
    8/59 QIAGEN miScript miRNA Assays for microRNAs that regulate ZNRF2 (see all 59):
    hsa-miR-607 hsa-miR-15a hsa-miR-503 hsa-miR-605 hsa-miR-219-5p hsa-miR-570 hsa-miR-105 hsa-miR-374a*
    SwitchGear 3'UTR luciferase reporter plasmid: ZNRF2 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZNRF2 (see all 6)
    OriGene siRNA: ZNRF2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZNRF2

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for ZNRF2

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNRF2 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNRF2
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: ZNRF2 (NM_147128)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ZNRF2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNRF2 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for ZNRF2
    Search LifeMap BioReagents cell lines for ZNRF2

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNRF2

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008270zinc ion binding IEA--
    GO:0016874ligase activity IEA--


    ZNRF2 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for ZNRF2:
     Decreased viability  Synthetic lethal with Ras 


    Pathways & Interactions
    for ZNRF2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    UniProtKB/Swiss-Prot: ZNRF2_HUMAN, Q8NHG8
    Pathway: Protein modification; protein ubiquitination

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNRF2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    5/7 Interacting proteins for ZNRF2 (Q8NHG82, 3 ENSP000003238794) via UniProtKB, MINT, STRING, and/or I2D (see all 7)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBE2D2P628373, ENSP000003817174I2D: score=1 STRING: ENSP00000381717
    UBE2D3P610773, ENSP000003497224I2D: score=1 STRING: ENSP00000349722
    UBE2NP610883, ENSP000003161764I2D: score=1 STRING: ENSP00000316176
    UBE2D1P516683, ENSP000003630194I2D: score=1 STRING: ENSP00000363019
    UBE2D4Q9Y2X83, ENSP000002224024I2D: score=1 STRING: ENSP00000222402
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016567protein ubiquitination IEA--


    ZNRF2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for ZNRF2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZNRF2

    4 HMDB Compounds for ZNRF2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--
    Search CenterWatch for drugs/clinical trials and news about ZNRF2 

    Transcripts
    for ZNRF2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ZNRF2 gene: 
    NM_147128.3  

    Unigene Cluster for ZNRF2:

    Zinc and ring finger 2
    Hs.263912  [show with all ESTs]
    Unigene Representative Sequence: AF513707
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000323037(uc003tat.3) ENST00000459998 ENST00000442800 ENST00000414621


    miRNA
    Products:             		 OriGene 3'-UTR Clone: ZNRF2
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ZNRF2
    8/59 QIAGEN miScript miRNA Assays for microRNAs that regulate ZNRF2 (see all 59):
    hsa-miR-607 hsa-miR-15a hsa-miR-503 hsa-miR-605 hsa-miR-219-5p hsa-miR-570 hsa-miR-105 hsa-miR-374a*
    SwitchGear 3'UTR luciferase reporter plasmid: ZNRF2 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZNRF2 (see all 6)
    OriGene siRNA: ZNRF2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZNRF2
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNRF2 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNRF2
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: ZNRF2 (NM_147128)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ZNRF2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNRF2 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNRF2
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat ZNRF2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNRF2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNRF2

    Additional cDNA sequence: 

    AF513707.1 AF527533.1 AK025240.1 AY054122.1 

    7 DOTS entries:

    DT.445901  DT.310584  DT.121108459  DT.91726658  DT.75128085  DT.121108533  DT.432266 

    24/190 AceView cDNA sequences (see all 190):

    AW000962 BM787187 CB155854 AI582195 CK904110 BI966092 AW118226 AI801498 
    AA749126 AA907191 BQ014946 AA904789 BM797760 AA825991 BX485301 BG427982 
    AW297790 AA453611 AI123940 NM_152747 AI902198 CK904111 AW166368 BM468619 

    GeneLoc Exon Structure


    Expression
    for ZNRF2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZNRF2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TGTTATTACT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See ZNRF2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZNRF2

    SOURCE GeneReport for Unigene cluster: Hs.263912

    UniProtKB/Swiss-Prot: ZNRF2_HUMAN, Q8NHG8
    Tissue specificity: Highly expressed in the brain, with higher expression during development than in adult. Expressed
    also in mammary glands, testis, colon and kidney

        SABiosciences Expression via Pathway-Focused PCR Array including ZNRF2: 
              Ubiquitin Ligases in human mouse rat

    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNRF2
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat ZNRF2
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNRF2
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNRF2
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNRF2

    Orthologs
    for ZNRF2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for ZNRF2 gene from 6/18 species (see all 18)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves ZNRF21 zinc and ring finger 2 87.97(n)
    94.74(a)    		   420678  XM_418778.3  XP_418778.3 
    lizard
    (Anolis carolinensis)    		 Reptilia ZNRF26
    		 --
    		 71(a)
    		 1 ↔ 1
    		 6(36269689-36328728)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.124752 Xenopus laevis transcribed sequence with weak similarity to protein refNP_115644.1 (H.sapiens) hypothetical protein DKFZp434E229; hypothetical protein FLJ14846 [Homo sapiens] less 84.97(n)    BJ086886.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii znrf2b1 zinc and ring finger 2b 68.36(n)
    73.73(a)    		   767761  NM_001076728.1  NP_001070196.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG144351 CG14435 52.92(n)
    48.33(a)    		   31628  NM_132131.3  NP_572359.2 
    worm
    (Caenorhabditis elegans)    		 Secernentea Y71F9AL.101 Protein Y71F9AL.10 52.59(n)
    52.59(a)    		   171852  NM_058658.4  NP_491059.2 


    ENSEMBL Gene Tree for ZNRF2 (if available)
    TreeFam Gene Tree for ZNRF2 (if available) 

    Paralogs
    for ZNRF2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZNRF2 gene
    ZNRF12  
    1 SIMAP similar gene for ZNRF2 using alignment to 2 protein entries:     ZNRF2_HUMAN (see all proteins):
    ZNRF1

    ZNRF2 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for ZNRF2
    PGOHUM00000232633


    Genomic Variants
    for ZNRF2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1437 NCBI SNPs in ZNRF2 are shown (see all 1437)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 7 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs2007995451,2
    		--30322210(+) GTCTC-/AAAT  
                AAATA     		1 -- us2k10--------
    rs69780121,2
    		C,F,A,H,--30322341(+) AAAGAA/GGGCCA 1 -- us2k1 trp317Minor allele frequency- G:0.26NS EA NA WA CSA 2101
    rs796995981,2
    		F,--30322482(+) GTTAAT/AGAGTG 1 -- us2k11Minor allele frequency- A:0.07WA 118
    rs1861237611,2
    		--30322547(+) ACTCAC/TTCATT 1 -- us2k10--------
    rs1894156511,2
    		--30322645(+) GCCAAC/TTGAGT 1 -- us2k10--------
    rs1814656611,2
    		--30322681(+) AATAAC/TAACAT 1 -- us2k10--------
    rs1869375521,2
    		--30322880(+) ATGTGA/TGTTTG 1 -- us2k10--------
    rs69446721,2
    		C,F,A,H,--30322890(+) GTGTAC/TACAGA 1 -- us2k111Minor allele frequency- T:0.15NS NA CSA WA 1401
    rs1914048821,2
    		--30322999(+) CAAATA/TGTGAA 1 -- us2k10--------
    rs1416529071,2
    		--30323061(+) TTTTCA/TAGTAG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ZNRF2 (30323923 - 30452118 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for ZNRF2: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNRF2
    DNA2.0 Custom Variant and Variant Library Synthesis for ZNRF2

    Disorders / Diseases
    for ZNRF2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ZNRF2 for disorders           About GeneDecksing

    OMIM gene information: 612061    OMIM disorders: --

    1 disease for ZNRF2:    About MalaCards
    neuronitis


    Export disorders for ZNRF2 gene to outside databases

    Publications
    for ZNRF2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZNRF2 gene, integrated from 9 sources (see all 14):
    (articles sorted by number of sources associating them with ZNRF2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. ZNRF proteins constitute a family of presynaptic E3 ubiquitin ligases. (PubMed id 14561866)1, 2, 9 Araki T. and Milbrandt J. (2003)
    2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    3. The RING finger protein RNF8 recruits UBC13 for lysine 63-based self polyubiquitylation. (PubMed id 16215985)1, 2 Plans V.... Thomson T.M. (2006)
    4. ZNRF2 is released from membranes by growth factors and , together with ZNRF1, regulates the Na+/K+ATPase. (PubMed id 22797923)1 Hoxhaj G....MacKintosh C. (2012)
    5. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
    6. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    7. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
    8. Analysis of electrostatic contributions to the selectivity of interactions between RING-finger domains and ubiquitin-conjugating enzymes. (PubMed id 18615712)1 Scheper J....Thomson T.M. (2009)
    9. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
    10. A comprehensive framework of E2-RING E3 interactions of the human ubiquitin-proteasome system. (PubMed id 19690564)1 van Wijk S.J....Timmers H.T. (2009)

    External Searches for ZNRF2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing ZNRF2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 223082 HGNC: 22316 AceView: ZNRF2andDKFZp586I1420 Ensembl:ENSG00000180233 euGenes: HUgn223082
    ECgene: ZNRF2 H-InvDB: ZNRF2

    Other Databases showing ZNRF2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing ZNRF2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZNRF2 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for ZNRF2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ZNRF2 gene:
    Search GeneIP for patents involving ZNRF2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for ZNRF2 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   Browse OriGene shRNA RFPs  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZNRF2   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNRF2  
     OriGene Protein Over-expression Lysate for ZNRF2   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for ZNRF2   OriGene 3'-UTR Clone for ZNRF2  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNRF2   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNRF2  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ZNRF2   OriGene Custom Protein Services for ZNRF2  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ZNRF2
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNRF2
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNRF2
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZNRF2
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNRF2
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNRF2
     GenScript Custom Purified and Recombinant Proteins Services for ZNRF2 GenScript cDNA clones with any tag delivered in your preferred vector for ZNRF2
     GenScript Custom Assay Services for ZNRF2 GenScript Custom Superior Antibodies Services for ZNRF2
     GenScript Custom overexpressing Cell Line Services for ZNRF2 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in ZNRF2 promoter
     Search Chromatin IP Primers for ZNRF2
     RT2 qPCR Primer Assay in human, mouse / rat ZNRF2
     Search GNC Networks for ZNRF2
     SABiosciences PCR Arrays including human, mouse, rat ZNRF2
     Search Tocris compounds for ZNRF2
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     ZNRF2 antibodies
     ZNRF2 proteins
     Antibodies for ZNRF2
     See all of Abcam's Antibodies, Kits and Proteins for ZNRF2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     ZNRF2 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for ZNRF2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNRF2
     SwitchGear 3'UTR luciferase reporter plasmids for ZNRF2
     SwitchGear Promoter luciferase reporter plasmids for ZNRF2
     Search ThermoFisher Antibodies for ZNRF2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNRF2
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      ZNRF2 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4