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Aliases for ZNRF2 Gene

Aliases for ZNRF2 Gene

  • Zinc And Ring Finger 2 2 3 5
  • Zinc And Ring Finger 2, E3 Ubiquitin Protein Ligase 2 3
  • RING-Type E3 Ubiquitin Transferase ZNRF2 3 4
  • Zinc/RING Finger Protein 2 3 4
  • RING Finger Protein 202 3 4
  • Protein Ells2 3 4
  • RNF202 3 4
  • E3 Ubiquitin-Protein Ligase ZNRF2 3
  • Zinc Finger/RING Finger 2 3
  • EC 2.3.2.27 4

External Ids for ZNRF2 Gene

Previous GeneCards Identifiers for ZNRF2 Gene

  • GC07P030068
  • GC07P030097
  • GC07P030290

Summaries for ZNRF2 Gene

GeneCards Summary for ZNRF2 Gene

ZNRF2 (Zinc And Ring Finger 2) is a Protein Coding gene. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. GO annotations related to this gene include ligase activity and ubiquitin protein ligase activity. An important paralog of this gene is ZNRF1.

UniProtKB/Swiss-Prot for ZNRF2 Gene

  • May play a role in the establishment and maintenance of neuronal transmission and plasticity via its ubiquitin ligase activity. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNRF2 Gene

Genomics for ZNRF2 Gene

Regulatory Elements for ZNRF2 Gene

Enhancers for ZNRF2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07G030161 1.9 FANTOM5 Ensembl ENCODE dbSUPER 21.7 -119.8 -119751 5.4 PKNOX1 ARID4B FEZF1 YY1 TCF12 GATA2 FOS ZNF263 SP5 REST ZNRF2 MIR550A1 NOD1 MTURN LOC105375217 RPS27P16 ENSG00000251660
GH07G030168 1.8 FANTOM5 Ensembl ENCODE dbSUPER 20.4 -113.1 -113055 6.4 FOXA2 PKNOX1 ZFP64 INSM2 SIN3A FEZF1 RAD21 RARA FOS IKZF2 ZNRF2 MIR550A1 NOD1 MTURN LOC105375217 RPS27P16 GC07P030172
GH07G030347 1.5 FANTOM5 Ensembl ENCODE 16.6 +64.3 64335 3.2 PKNOX1 ATF1 FEZF1 ZNF766 ZNF207 FOS JUNB TBX21 SMARCB1 ZNF592 ZNRF2 MIR550A1 NOD1 GC07P030343 ENSG00000281593
GH07G030158 1.3 Ensembl ENCODE dbSUPER 12.1 -124.4 -124421 2.0 SOX13 CTCF ESRRA KLF1 MAX ZNF48 RAD21 RARA CTBP1 EED MIR550A1 ZNRF2 NOD1 MTURN LOC105375217 ENSG00000251660 RPS27P16
GH07G030238 1.5 FANTOM5 Ensembl ENCODE 10.2 -45.2 -45157 1.2 PKNOX1 FOXA2 TBL1XR1 NFIB WRNIP1 FEZF1 RAD21 YY1 SCRT2 FOS ZNRF2 GC07M030247 LOC105375217
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNRF2 on UCSC Golden Path with GeneCards custom track

Promoters for ZNRF2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000210338 1493 3601 HDGF PKNOX1 MLX ARNT ARID4B SIN3A DMAP1 YY1 ZNF766 CBX5

Genomic Location for ZNRF2 Gene

Chromosome:
7
Start:
30,284,307 bp from pter
End:
30,367,692 bp from pter
Size:
83,386 bases
Orientation:
Plus strand

Genomic View for ZNRF2 Gene

Genes around ZNRF2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNRF2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNRF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNRF2 Gene

Proteins for ZNRF2 Gene

  • Protein details for ZNRF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NHG8-ZNRF2_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase ZNRF2
    Protein Accession:
    Q8NHG8

    Protein attributes for ZNRF2 Gene

    Size:
    242 amino acids
    Molecular mass:
    24115 Da
    Quaternary structure:
    • Interacts with UBE2N.

neXtProt entry for ZNRF2 Gene

Post-translational modifications for ZNRF2 Gene

  • Ubiquitination at posLast=165165 and posLast=182182
  • Modification sites at PhosphoSitePlus

Other Protein References for ZNRF2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNRF2 Gene

Domains & Families for ZNRF2 Gene

Gene Families for ZNRF2 Gene

Protein Domains for ZNRF2 Gene

Suggested Antigen Peptide Sequences for ZNRF2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NHG8

UniProtKB/Swiss-Prot:

ZNRF2_HUMAN :
  • The RING-type zinc finger domain is required for E3 ligase activity.
Domain:
  • The RING-type zinc finger domain is required for E3 ligase activity.
genes like me logo Genes that share domains with ZNRF2: view

Function for ZNRF2 Gene

Molecular function for ZNRF2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.
UniProtKB/Swiss-Prot Function:
May play a role in the establishment and maintenance of neuronal transmission and plasticity via its ubiquitin ligase activity. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.

Enzyme Numbers (IUBMB) for ZNRF2 Gene

Gene Ontology (GO) - Molecular Function for ZNRF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity TAS --
GO:0008270 zinc ion binding IEA --
GO:0016740 transferase activity IEA --
GO:0046872 metal ion binding IEA --
GO:0061630 ubiquitin protein ligase activity IDA 22797923
genes like me logo Genes that share ontologies with ZNRF2: view
genes like me logo Genes that share phenotypes with ZNRF2: view

Animal Model Products

CRISPR Products

miRNA for ZNRF2 Gene

miRTarBase miRNAs that target ZNRF2

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNRF2 Gene

Localization for ZNRF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNRF2 Gene

Endosome membrane; Peripheral membrane protein. Lysosome membrane; Peripheral membrane protein. Cell junction, synapse, presynaptic cell membrane; Peripheral membrane protein. Note=Present in presynaptic plasma membranes in neurons.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNRF2 gene
Compartment Confidence
plasma membrane 5
cytosol 5
lysosome 3
endosome 3
extracellular 2
mitochondrion 1
peroxisome 1
nucleus 1

Gene Ontology (GO) - Cellular Components for ZNRF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 22797923
GO:0005764 lysosome IEA --
GO:0005765 lysosomal membrane IEA --
GO:0005768 endosome IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with ZNRF2: view

Pathways & Interactions for ZNRF2 Gene

genes like me logo Genes that share pathways with ZNRF2: view

UniProtKB/Swiss-Prot Q8NHG8-ZNRF2_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for ZNRF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000209 protein polyubiquitination TAS --
GO:0016567 protein ubiquitination IEA --
GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process IBA --
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IBA --
genes like me logo Genes that share ontologies with ZNRF2: view

No data available for SIGNOR curated interactions for ZNRF2 Gene

Drugs & Compounds for ZNRF2 Gene

(3) Drugs for ZNRF2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Adenosine monophosphate Approved Nutra 0
Adenosine triphosphate Approved Nutra 0

(1) Additional Compounds for ZNRF2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
pyrophosphate
  • (4-)Diphosphoric acid ion
  • (P2O74-)Diphosphate
  • Diphosphate
  • Diphosphoric acid
  • PPi
14000-31-8
genes like me logo Genes that share compounds with ZNRF2: view

Transcripts for ZNRF2 Gene

mRNA/cDNA for ZNRF2 Gene

Unigene Clusters for ZNRF2 Gene

Zinc and ring finger 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNRF2 Gene

No ASD Table

Relevant External Links for ZNRF2 Gene

GeneLoc Exon Structure for
ZNRF2
ECgene alternative splicing isoforms for
ZNRF2

Expression for ZNRF2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNRF2 Gene

Protein differential expression in normal tissues from HIPED for ZNRF2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (9.8), Stomach (9.2), Testis (8.8), and Ovary (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZNRF2 Gene



NURSA nuclear receptor signaling pathways regulating expression of ZNRF2 Gene:

ZNRF2

SOURCE GeneReport for Unigene cluster for ZNRF2 Gene:

Hs.263912

mRNA Expression by UniProt/SwissProt for ZNRF2 Gene:

Q8NHG8-ZNRF2_HUMAN
Tissue specificity: Highly expressed in the brain, with higher expression during development than in adult. Expressed also in mammary glands, testis, colon and kidney.

Evidence on tissue expression from TISSUES for ZNRF2 Gene

  • Liver(4.3)
genes like me logo Genes that share expression patterns with ZNRF2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNRF2 Gene

Orthologs for ZNRF2 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNRF2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNRF2 34 35
  • 97.88 (n)
cow
(Bos Taurus)
Mammalia ZNRF2 34 35
  • 92.09 (n)
mouse
(Mus musculus)
Mammalia Znrf2 34 16 35
  • 84.84 (n)
rat
(Rattus norvegicus)
Mammalia Znrf2 34
  • 83.91 (n)
oppossum
(Monodelphis domestica)
Mammalia ZNRF2 35
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZNRF2 34 35
  • 88.06 (n)
lizard
(Anolis carolinensis)
Reptilia ZNRF2 35
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia znrf2 34
  • 75.49 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.12475 34
zebrafish
(Danio rerio)
Actinopterygii znrf2b 34 35
  • 66.83 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5607 34
fruit fly
(Drosophila melanogaster)
Insecta CG14435 35
  • 33 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y71F9AL.10 35
  • 40 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3182 35
  • 36 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.13301 34
Species where no ortholog for ZNRF2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZNRF2 Gene

ENSEMBL:
Gene Tree for ZNRF2 (if available)
TreeFam:
Gene Tree for ZNRF2 (if available)

Paralogs for ZNRF2 Gene

Paralogs for ZNRF2 Gene

(1) SIMAP similar genes for ZNRF2 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for ZNRF2 Gene

genes like me logo Genes that share paralogs with ZNRF2: view

Variants for ZNRF2 Gene

Sequence variations from dbSNP and Humsavar for ZNRF2 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1000044239 -- 30,304,966(+) TTGCA(C/T)TTAAA intron-variant
rs1000069194 -- 30,338,993(+) ACTGT(A/G)GTTTT intron-variant
rs1000113953 -- 30,283,481(+) TCTCA(A/G)AGCAG intron-variant, upstream-variant-2KB
rs1000143331 -- 30,352,421(+) TTTTC(C/T)AGTCT intron-variant
rs1000198576 -- 30,364,549(+) TGGAG(G/T)GGTAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNRF2 Gene

Variant ID Type Subtype PubMed ID
nsv1019527 CNV gain 25217958
nsv1068321 OTHER inversion 25765185
nsv1074493 CNV deletion 25765185
nsv1144169 CNV deletion 24896259
nsv1148830 OTHER inversion 26484159
nsv436557 CNV deletion 17901297
nsv523514 CNV gain 19592680
nsv525379 CNV loss 19592680
nsv970455 CNV duplication 23825009
nsv981445 CNV duplication 23825009

Variation tolerance for ZNRF2 Gene

Gene Damage Index Score: 4.08; 60.95% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNRF2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNRF2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNRF2 Gene

Disorders for ZNRF2 Gene

Relevant External Links for ZNRF2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNRF2

No disorders were found for ZNRF2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNRF2 Gene

Publications for ZNRF2 Gene

  1. ZNRF proteins constitute a family of presynaptic E3 ubiquitin ligases. (PMID: 14561866) Araki T. … Milbrandt J. (J. Neurosci. 2003) 3 4 22 64
  2. ZNRF2 is released from membranes by growth factors and, together with ZNRF1, regulates the Na+/K+ATPase. (PMID: 22797923) Hoxhaj G. … MacKintosh C. (J. Cell. Sci. 2012) 2 3 64
  3. The RING finger protein RNF8 recruits UBC13 for lysine 63-based self polyubiquitylation. (PMID: 16215985) Plans V. … Thomson T.M. (J. Cell. Biochem. 2006) 3 4 64
  4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 64
  5. The E3 ubiquitin ligase ZNRF2 is a substrate of mTORC1 and regulates its activation by amino acids. (PMID: 27244671) Hoxhaj G. … MacKintosh C. (Elife 2016) 3 64

Products for ZNRF2 Gene

Sources for ZNRF2 Gene

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