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Aliases for ZNRF1 Gene

Aliases for ZNRF1 Gene

  • Zinc And Ring Finger 1, E3 Ubiquitin Protein Ligase 2 3
  • NIN283 3 4 6
  • Nerve Injury-Induced Gene 283 Protein 3 4
  • Zinc/RING Finger Protein 1 3 4
  • E3 Ubiquitin-Protein Ligase ZNRF1 3
  • Zinc And Ring Finger Protein 1 3
  • Zinc And Ring Finger 1 2
  • Nerve Injury Gene 283 3
  • EC 6.3.2.- 4
  • EC 6.3.2 63

External Ids for ZNRF1 Gene

Previous GeneCards Identifiers for ZNRF1 Gene

  • GC16P074812
  • GC00U917013
  • GC16P073590
  • GC16P060784

Summaries for ZNRF1 Gene

Entrez Gene Summary for ZNRF1 Gene

  • This gene encodes an E3 ubiquitin-protein ligase that plays a role in neural-cell differentiation. Overexpression of this gene causes neurite-like elongation. The encoded protein contains both a zinc finger and a RING finger motif and is localized in the endosome/lysosome compartment, indicating that it may be involved in ubiquitin-mediated protein modification, and in synaptic vessicle membranes in neurons. [provided by RefSeq, Feb 2012]

GeneCards Summary for ZNRF1 Gene

ZNRF1 (Zinc And Ring Finger 1, E3 Ubiquitin Protein Ligase) is a Protein Coding gene. GO annotations related to this gene include ubiquitin-protein transferase activity. An important paralog of this gene is ZNRF2.

UniProtKB/Swiss-Prot for ZNRF1 Gene

  • E3 ubiquitin-protein ligase that mediates the ubiquitination of AKT1 and GLUL, thereby playing a role in neuron cells differentiation. Plays a role in the establishment and maintenance of neuronal transmission and plasticity. Regulates Schwann cells differentiation by mediating ubiquitination of GLUL. Promotes neurodegeneration by mediating Lys-48-linked polyubiquitination and subsequent degradation of AKT1 in axons: degradation of AKT1 prevents AKT1-mediated phosphorylation of GSK3B, leading to GSK3B activation and phosphorylation of DPYSL2/CRMP2 followed by destabilization of microtubule assembly in axons (Probable).

Gene Wiki entry for ZNRF1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNRF1 Gene

Genomics for ZNRF1 Gene

Regulatory Elements for ZNRF1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ZNRF1 Gene

Start:
74,999,017 bp from pter
End:
75,110,994 bp from pter
Size:
111,978 bases
Orientation:
Plus strand

Genomic View for ZNRF1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNRF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNRF1 Gene

Proteins for ZNRF1 Gene

  • Protein details for ZNRF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8ND25-ZNRF1_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase ZNRF1
    Protein Accession:
    Q8ND25
    Secondary Accessions:
    • D3DUJ9
    • Q9H083

    Protein attributes for ZNRF1 Gene

    Size:
    227 amino acids
    Molecular mass:
    23783 Da
    Quaternary structure:
    • Interacts with AKT1, GLUL and TUBB2A.

    Alternative splice isoforms for ZNRF1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNRF1 Gene

Proteomics data for ZNRF1 Gene at MOPED

Selected DME Specific Peptides for ZNRF1 Gene

Post-translational modifications for ZNRF1 Gene

  • Ubiquitination at Lys150 and Lys167
  • Modification sites at PhosphoSitePlus

Other Protein References for ZNRF1 Gene

Domains for ZNRF1 Gene

Gene Families for ZNRF1 Gene

HGNC:
  • RNF :RING-type (C3HC4) zinc fingers

Protein Domains for ZNRF1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for ZNRF1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8ND25

UniProtKB/Swiss-Prot:

ZNRF1_HUMAN :
  • Q8ND25
Domain:
  • The RING-type zinc finger domain is required for E3 ligase activity.
Similarity:
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with ZNRF1: view

Function for ZNRF1 Gene

Molecular function for ZNRF1 Gene

UniProtKB/Swiss-Prot Function: E3 ubiquitin-protein ligase that mediates the ubiquitination of AKT1 and GLUL, thereby playing a role in neuron cells differentiation. Plays a role in the establishment and maintenance of neuronal transmission and plasticity. Regulates Schwann cells differentiation by mediating ubiquitination of GLUL. Promotes neurodegeneration by mediating Lys-48-linked polyubiquitination and subsequent degradation of AKT1 in axons: degradation of AKT1 prevents AKT1-mediated phosphorylation of GSK3B, leading to GSK3B activation and phosphorylation of DPYSL2/CRMP2 followed by destabilization of microtubule assembly in axons (Probable).

Enzyme Numbers (IUBMB) for ZNRF1 Gene

Gene Ontology (GO) - Molecular Function for ZNRF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity ISS --
GO:0005515 protein binding IPI 19549727
GO:0008270 zinc ion binding IEA --
GO:0016874 ligase activity IEA --
GO:0046872 metal ion binding --
genes like me logo Genes that share ontologies with ZNRF1: view

Phenotypes for ZNRF1 Gene

genes like me logo Genes that share phenotypes with ZNRF1: view

Animal Model Products

CRISPR Products

miRNA for ZNRF1 Gene

miRTarBase miRNAs that target ZNRF1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNRF1

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for ZNRF1 Gene

Localization for ZNRF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNRF1 Gene

Endosome. Lysosome. Membrane; Peripheral membrane protein. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Peripheral membrane protein. Note=Associated with synaptic vesicle membranes in neurons.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNRF1 Gene COMPARTMENTS Subcellular localization image for ZNRF1 gene
Compartment Confidence
endosome 5
lysosome 5
vacuole 5
extracellular 2
mitochondrion 2
cytosol 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for ZNRF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005764 lysosome IEA --
GO:0005768 endosome IDA --
GO:0005829 cytosol IDA 22797923
GO:0016020 membrane IDA 22797923
GO:0030054 cell junction IEA --
genes like me logo Genes that share ontologies with ZNRF1: view

Pathways for ZNRF1 Gene

SuperPathways for ZNRF1 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

UniProtKB/Swiss-Prot Q8ND25-ZNRF1_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for ZNRF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process ISS --
GO:0070936 protein K48-linked ubiquitination ISS --
genes like me logo Genes that share ontologies with ZNRF1: view

No data available for Pathways by source for ZNRF1 Gene

Compounds for ZNRF1 Gene

(4) HMDB Compounds for ZNRF1 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine monophosphate
  • 5'-AMP
61-19-8
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
Phosphoric acid
  • acide phosphorique (FRENCH)
7664-38-2
Pyrophosphate
  • (4-)Diphosphoric acid ion
14000-31-8
genes like me logo Genes that share compounds with ZNRF1: view

Transcripts for ZNRF1 Gene

Unigene Clusters for ZNRF1 Gene

Zinc and ring finger 1, E3 ubiquitin protein ligase:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNRF1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNRF1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b
SP1: - -
SP2: - - -
SP3: - - - -
SP4: -
SP5:

Relevant External Links for ZNRF1 Gene

GeneLoc Exon Structure for
ZNRF1
ECgene alternative splicing isoforms for
ZNRF1

Expression for ZNRF1 Gene

mRNA expression in normal human tissues for ZNRF1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZNRF1 Gene

SOURCE GeneReport for Unigene cluster for ZNRF1 Gene Hs.427284

mRNA Expression by UniProt/SwissProt for ZNRF1 Gene

Q8ND25-ZNRF1_HUMAN
Tissue specificity: Expressed primarily in the nervous system, with expression higher in developing brain relative to adult. Expressed at low levels in testis and thymus.
genes like me logo Genes that share expressions with ZNRF1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for ZNRF1 Gene

Orthologs for ZNRF1 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNRF1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNRF1 35
  • 99.85 (n)
  • 100 (a)
ZNRF1 36
  • 82 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZNRF1 35
  • 95.3 (n)
  • 97.36 (a)
ZNRF1 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZNRF1 35
  • 96.67 (n)
  • 100 (a)
ZNRF1 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Znrf1 35
  • 95.01 (n)
  • 99.12 (a)
Znrf1 16
Znrf1 36
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZNRF1 36
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Znrf1 35
  • 95.01 (n)
  • 98.68 (a)
chicken
(Gallus gallus)
Aves ZNRF1 35
  • 84.74 (n)
  • 90.85 (a)
lizard
(Anolis carolinensis)
Reptilia ZNRF1 36
  • 98 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia znrf1 35
  • 75.56 (n)
  • 81.54 (a)
zebrafish
(Danio rerio)
Actinopterygii zgc77896 35
znrf1 35
  • 78.45 (n)
  • 86.51 (a)
znrf1 36
  • 83 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG14435 36
  • 29 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y71F9AL.10 36
  • 37 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3182 36
  • 31 (a)
OneToMany
Species with no ortholog for ZNRF1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZNRF1 Gene

ENSEMBL:
Gene Tree for ZNRF1 (if available)
TreeFam:
Gene Tree for ZNRF1 (if available)

Paralogs for ZNRF1 Gene

Paralogs for ZNRF1 Gene

Selected SIMAP similar genes for ZNRF1 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for ZNRF1 Gene

genes like me logo Genes that share paralogs with ZNRF1: view

Variants for ZNRF1 Gene

Sequence variations from dbSNP and Humsavar for ZNRF1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs3135 -- 75,011,289(+) ATATT(A/G)TTCTA intron-variant
rs15819 -- 75,110,367(-) GAACC(G/T)GCTCG utr-variant-3-prime
rs878891 -- 75,081,805(-) CCTCT(C/T)CCTCT intron-variant
rs948794 -- 75,003,466(+) actct(A/G)actct intron-variant
rs989925 -- 75,107,162(-) GGGGA(C/T)GTGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNRF1 Gene

Variant ID Type Subtype PubMed ID
nsv833280 CNV Loss 17160897
nsv906908 CNV Loss 21882294
nsv103814 CNV Loss 16902084
nsv1878 CNV Insertion 18451855
esv2714703 CNV Deletion 23290073
esv3003 CNV Deletion 18987735
esv2714704 CNV Deletion 23290073
esv1789347 CNV Deletion 17803354

Relevant External Links for ZNRF1 Gene

HapMap Linkage Disequilibrium report
ZNRF1
Human Gene Mutation Database (HGMD)
ZNRF1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNRF1 Gene

Disorders for ZNRF1 Gene

Relevant External Links for ZNRF1

Genetic Association Database (GAD)
ZNRF1
Human Genome Epidemiology (HuGE) Navigator
ZNRF1
genes like me logo Genes that share disorders with ZNRF1: view

No data available for UniProtKB/Swiss-Prot for ZNRF1 Gene

Publications for ZNRF1 Gene

  1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4
  2. Identification of genes induced in peripheral nerve after injury. Expression profiling and novel gene discovery. (PMID: 11427537) Araki T. … Milbrandt J. (J. Biol. Chem. 2001) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Fine mapping and association studies of a high-density lipoprotein cholesterol linkage region on chromosome 16 in French-Canadian subjects. (PMID: 19844255) Dastani Z. … Genest J. (Eur. J. Hum. Genet. 2010) 3 48
  5. ZNRF proteins constitute a family of presynaptic E3 ubiquitin ligases. (PMID: 14561866) Araki T. … Milbrandt J. (J. Neurosci. 2003) 3 4

Products for ZNRF1 Gene

Sources for ZNRF1 Gene

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