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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZNRF1 Gene

protein-coding   GIFtS: 52
GCID: GC16P075033

zinc and ring finger 1, E3 ubiquitin protein ligase

(Previous name: zinc and ring finger 1 )
 Explore 3 diseases affiliated with
ZNRF1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for ZNRF1    

Aliases
for ZNRF1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Zinc And Ring Finger 1, E3 Ubiquitin Protein Ligase1 2     Zinc And Ring Finger 11
NIN2832 3 5     E3 Ubiquitin-Protein Ligase ZNRF12
Nerve Injury-Induced Gene 283 Protein2 3     Nerve Injury Gene 2832
Zinc/RING Finger Protein 12 3     Zinc And Ring Finger Protein 12
DKFZp434E2291     EC 6.3.2.-3
FLJ148461     EC 6.3.28
Nin2831     

External Ids:    HGNC: 184521   Entrez Gene: 849372   Ensembl: ENSG000001861877   OMIM: 6120605   UniProtKB: Q8ND253   

Export aliases for ZNRF1 gene to outside databases

Previous GC identifers: GC16P074812 GC00U917013 GC16P073590 GC16P060784


Summaries
for ZNRF1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for ZNRF1:
This gene encodes an E3 ubiquitin-protein ligase that plays a role in neural-cell differentiation. Overexpression of
this gene causes neurite-like elongation. The encoded protein contains both a zinc finger and a RING finger motif and
is localized in the endosome/lysosome compartment, indicating that it may be involved in ubiquitin-mediated protein
modification, and in synaptic vessicle membranes in neurons. (provided by RefSeq, Feb 2012)

UniProtKB/Swiss-Prot: ZNRF1_HUMAN, Q8ND25
Function: E3 ubiquitin-protein ligase that mediates the ubiquitination of AKT1 and GLUL, thereby playing a role in
neuron cells differentiation. Plays a role in the establishment and maintenance of neuronal transmission and
plasticity. Regulates Schwann cells differentiation by mediating ubiquitination of GLUL. Promotes neurodegeneration by
mediating 'Lys-48'-linked polyubiquitination and subsequent degradation of AKT1 in axons: degradation of AKT1 prevents
AKT1-mediated phosphorylation of GSK3B, leading to GSK3B activation and phosphorylation of DPYSL2/CRMP2 followed by
destabilization of microtubule assembly in axons (Probable)

Gene Wiki entry for ZNRF1


Genomic Views
for ZNRF1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NC_018927.1  NT_010498.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZNRF1 gene promoter:
         AML1a   AP-2gamma   Meis-1b   AREB6   STAT3   AP-2beta   Meis-1a   AP-2alpha   Meis-1   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ZNRF1 promoter sequence
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Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNRF1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q23.1   Ensembl cytogenetic band:  16q23.1   HGNC cytogenetic band: 16q22.3

ZNRF1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNRF1 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P075033:  view genomic region     (about GC identifiers)

Start:
 75,032,915 bp from pter      End:
 75,144,892 bp from pter
Size:
 111,978 bases      Orientation:
 plus strand

Proteins
for ZNRF1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: ZNRF1_HUMAN, Q8ND25 (See protein sequence)
Recommended Name: E3 ubiquitin-protein ligase ZNRF1  
Size: 227 amino acids; 23783 Da
Subunit: Interacts with AKT1, GLUL and TUBB2A (By similarity)
Subcellular location: Endosome. Lysosome. Membrane; Peripheral membrane protein. Cytoplasmic vesicle, secretory
vesicle, synaptic vesicle membrane; Peripheral membrane protein (Potential). Note=Associated with synaptic vesicle
membranes in neurons
Secondary accessions: D3DUJ9 Q9H083
Alternative splicing: 2 isoforms:  Q8ND25-1   Q8ND25-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ZNRF1: NX_Q8ND25

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q8ND25

    • 3 DME Specific Peptides for ZNRF1 (Q8ND25)
     CSKSVAS  QGDTIARLPCLCIYHK  HFIMCLSKPRLSYNDDVL 

    ZNRF1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_115644.1  
    ENSEMBL proteins: 
     ENSP00000335091   ENSP00000323362   ENSP00000456168   ENSP00000455601   ENSP00000462910  
     ENSP00000457606  

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    Uscn Proteins for ZNRF1

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005764lysosome IEA--
    GO:0005768endosome IDA--
    GO:0030054cell junction IEA--
    GO:0030672synaptic vesicle membrane IEA--


    ZNRF1 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for ZNRF1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ZNRF1 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR001841 Znf_RING
     IPR013083 Znf_RING/FYVE/PHD

    Graphical View of Domain Structure for InterPro Entry Q8ND25

    ProtoNet protein and cluster: Q8ND25

    1 Blocks protein family: IPB001841 Zn-finger

    UniProtKB/Swiss-Prot: ZNRF1_HUMAN, Q8ND25
    Domain: The RING-type zinc finger domain is required for E3 ligase activity (By similarity)
    Similarity: Contains 1 RING-type zinc finger


    Function
    for ZNRF1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: ZNRF1_HUMAN, Q8ND25
    Function: E3 ubiquitin-protein ligase that mediates the ubiquitination of AKT1 and GLUL, thereby playing a role in
    neuron cells differentiation. Plays a role in the establishment and maintenance of neuronal transmission and
    plasticity. Regulates Schwann cells differentiation by mediating ubiquitination of GLUL. Promotes neurodegeneration by
    mediating 'Lys-48'-linked polyubiquitination and subsequent degradation of AKT1 in axons: degradation of AKT1 prevents
    AKT1-mediated phosphorylation of GSK3B, leading to GSK3B activation and phosphorylation of DPYSL2/CRMP2 followed by
    destabilization of microtubule assembly in axons (Probable)

    Enzyme Numbers (IUBMB): EC 6.3.2.-1 EC 6.3.22

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    Inhib. RNA
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    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity ISS--
    GO:0005515protein binding IPI19690564
    GO:0008270zinc ion binding IEA--


    ZNRF1 for ontologies           About GeneDecksing


    4 GenomeRNAi human phenotypes for ZNRF1:
     G0/1 arrest  Increased G1 DNA content  Increased cell death HMECs cel  Synthetic lethal with Ras 


    Pathways & Interactions
    for ZNRF1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    UniProtKB/Swiss-Prot: ZNRF1_HUMAN, Q8ND25
    Pathway: Protein modification; protein ubiquitination

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNRF1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

    5/14 Interacting proteins for ZNRF1 (Q8ND251, 3 ENSP000003350914) via UniProtKB, MINT, STRING, and/or I2D (see all 14)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBE2D2P628371, 3, ENSP000003817174EBI-2129250,EBI-347677 I2D: score=2 STRING: ENSP00000381717
    UBE2D3P610771, 3, ENSP000003497224EBI-2129250,EBI-2809412 I2D: score=2 STRING: ENSP00000349722
    UBE2NP610881, 3, ENSP000003161764EBI-2129250,EBI-1052908 I2D: score=2 STRING: ENSP00000316176
    UBE2V1Q134041, 3, ENSP000003403054EBI-2129250,EBI-1050671 I2D: score=2 STRING: ENSP00000340305
    UBE2D1P516681, 3, ENSP000003630194EBI-2129250,EBI-743540 I2D: score=2 STRING: ENSP00000363019
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0043161proteasomal ubiquitin-dependent protein catabolic process ISS--
    GO:0070936protein K48-linked ubiquitination ISS--


    ZNRF1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for ZNRF1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for ZNRF1

    4 HMDB Compounds for ZNRF1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--
    Search CenterWatch for drugs/clinical trials and news about ZNRF1 

    Transcripts
    for ZNRF1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ZNRF1 gene: 
    NM_032268.4  

    Unigene Cluster for ZNRF1:

    Zinc and ring finger 1, E3 ubiquitin protein ligase
    Hs.427284  [show with all ESTs]
    Unigene Representative Sequence: NM_032268
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000335325(uc010vmz.1 uc002fdk.3 uc002fdl.1 uc010cgr.1)
    ENST00000320619 ENST00000566250 ENST00000567962 ENST00000564320 ENST00000568511
    ENST00000579084 ENST00000566244 ENST00000568351 ENST00000568494 ENST00000568844


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    hsa-miR-3607-3p hsa-miR-607 hsa-miR-642a hsa-miR-1914* hsa-miR-938 hsa-miR-219-5p hsa-miR-30d hsa-miR-371-5p
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    Inhib. RNA
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    Clone
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    Additional cDNA sequence: 

    AK027752.1 AK294434.1 AL136903.1 AL834440.1 BC007235.1 

    8 DOTS entries:

    DT.311875  DT.100792987  DT.100760151  DT.100029009  DT.100775890  DT.95279682  DT.100645627  DT.121625620 

    24/234 AceView cDNA sequences (see all 234):

    BU856635 AI561230 BF063289 BE220339 BE669871 BI914730 BU542815 AI362118 
    AL136903 AA345830 BM917961 AI650345 AI144394 CR615201 AI635536 BF447788 
    AL390144 AA354443 AW236931 AI758253 AA361151 AI918934 AL834440 NM_032268 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for ZNRF1    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b
    SP1:              -     -                                             
    SP2:              -     -           -                                 
    SP3:              -     -           -                       -         
    SP4:                                -                                 
    SP5:                                                                  


    ECgene alternative splicing isoforms for ZNRF1

    Expression
    for ZNRF1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZNRF1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GTTCTCCCTT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See ZNRF1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZNRF1

    SOURCE GeneReport for Unigene cluster: Hs.427284

    UniProtKB/Swiss-Prot: ZNRF1_HUMAN, Q8ND25
    Tissue specificity: Expressed primarily in the nervous system, with expression higher in developing brain relative to
    adult. Expressed at low levels in testis and thymus

        SABiosciences Expression via Pathway-Focused PCR Array including ZNRF1: 
              Ubiquitin Ligases in human mouse rat

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    In Situ
    Assay Products:     
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    Orthologs
    for ZNRF1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for ZNRF1 gene from 7/18 species (see all 18)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Znrf11 , 5 zinc and ring finger 11, 5 95.01(n)1
    99.12(a)1    		   8 (57.98 cM)5
    1707371  NM_001168621.11  NP_001162092.11 
     1115360975 
    chicken
    (Gallus gallus)    		 Aves ZNRF11 zinc and ring finger 1 90.1(n)
    98.44(a)    		   425231  XM_003641904.1  XP_003641952.1 
    lizard
    (Anolis carolinensis)    		 Reptilia ZNRF16
    		 --
    		 98(a)
    		 1 ↔ 1
    		 GL343840.1(33966-34854)
    African clawed frog
    (Xenopus laevis)    		 Amphibia BC047964.12   -- 81.76(n)    BC047964.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii zgc778962 hypothetical protein MGC77896 79.69(n)   393844  BC063239.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG144356
    		 --
    		 29(a)
    		 1 → many
    		 X(6733455-6737953)
    worm
    (Caenorhabditis elegans)    		 Secernentea Y71F9AL.106
    		 Protein Y71F9AL.10
    		 36(a)
    		 1 → many
    		 I(2866431-2869378)


    ENSEMBL Gene Tree for ZNRF1 (if available)
    TreeFam Gene Tree for ZNRF1 (if available) 

    Paralogs
    for ZNRF1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZNRF1 gene
    ZNRF22  
    1 SIMAP similar gene for ZNRF1 using alignment to 5 protein entries:     ZNRF1_HUMAN (see all proteins):
    ZNRF2

    ZNRF1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for ZNRF1
    PGOHUM00000238232


    Genomic Variants
    for ZNRF1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2027 NCBI SNPs in ZNRF1 are shown (see all 2027)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 16 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1432654891,2
    		--75030941(+) AATACC/TTGTGA 1 -- us2k10--------
    rs1475419041,2
    		--75030948(+) GTGACA/GGGCTA 1 -- us2k10--------
    rs736120811,2
    		C,--75030951(+) ACGGGC/GTAGCC 1 -- us2k12Minor allele frequency- G:0.14WA 120
    rs1927410651,2
    		--75031007(+) GGTCCC/TCCAGT 1 -- us2k10--------
    rs1850289611,2
    		--75031010(+) CCCCCA/GGTTTA 1 -- us2k10--------
    rs1384494631,2
    		--75031040(+) AATAGA/GTGGAA 1 -- us2k10--------
    rs1477937791,2
    		C,--75031244(+) TACAC-/ATATATA 1 -- us2k10--------
    rs97086051,2
    		C,F,--75031253(+) TATATA/GTATCA 1 -- us2k12Minor allele frequency- G:0.37NA EA 240
    rs2017399171,2
    		--75031416(+) GGCTA-/AATT  
                ATTTA     		1 -- us2k10--------
    rs1386963831,2
    		C,--75031438(+) TTTCA-/TTTTTT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ZNRF1 (75032915 - 75144892 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for ZNRF1
         1 CNV: 5838
         1 Indel: 41588
    Human Gene Mutation Database (HGMD): ZNRF1

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    Disorders / Diseases
    for ZNRF1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ZNRF1 for disorders           About GeneDecksing

    OMIM gene information: 612060    OMIM disorders: --

    3 diseases for ZNRF1:    About MalaCards
    neuronitis    neurodegeneration    cholesterol

    Human Genome Epidemiology (HuGE) Navigator: ZNRF1 (1 document)

    Export disorders for ZNRF1 gene to outside databases

    Publications
    for ZNRF1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZNRF1 gene, integrated from 9 sources (see all 18):
    (articles sorted by number of sources associating them with ZNRF1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. ZNRF proteins constitute a family of presynaptic E3 ubiquitin ligases. (PubMed id 14561866)1, 2 Araki T. and Milbrandt J. (2003)
    3. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (2001)
    4. Identification of genes induced in peripheral nerve after injury. Expression profiling and novel gene discovery. (PubMed id 11427537)1, 2 Araki T.... Milbrandt J. (2001)
    5. ZNRF2 is released from membranes by growth factors and , together with ZNRF1, regulates the Na+/K+ATPase. (PubMed id 22797923)1 Hoxhaj G....MacKintosh C. (2012)
    6. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    7. Fine mapping and association studies of a high-densit y lipoprotein cholesterol linkage region on chromosome 16 in French-Canadian su bjects. (PubMed id 19844255)1 Dastani Z....Genest J. (2010)
    8. Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network. (PubMed id 19549727)1 Markson G....Sanderson C.M. (2009)
    9. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
    10. ZNRF1 interacts with tubulin and regulates cell morph ogenesis. (PubMed id 19737534)1 Yoshida K....Hatakeyama S. (2009)

    External Searches for ZNRF1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
    		PubMed
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    NCBI Bookshelf
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    Genome Databases showing ZNRF1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 84937 HGNC: 18452 AceView: ZNRF1 Ensembl:ENSG00000186187 euGenes: HUgn84937
    ECgene: ZNRF1 H-InvDB: ZNRF1

    Other Databases showing ZNRF1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing ZNRF1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZNRF1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for ZNRF1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ZNRF1 gene:
    Search GeneIP for patents involving ZNRF1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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