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ZNRF1 Gene

protein-coding   GIFtS: 56
GCID: GC16P075033

Zinc And Ring Finger 1, E3 Ubiquitin Protein Ligase

(Previous name: zinc and ring finger 1)
  Search for ZNRF1
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc And Ring Finger 1, E3 Ubiquitin Protein Ligase1 2     E3 Ubiquitin-Protein Ligase ZNRF12
NIN2832 3 5     Nerve Injury Gene 2832
Nerve Injury-Induced Gene 283 Protein2 3     Zinc And Ring Finger Protein 12
Zinc/RING Finger Protein 12 3     EC 6.3.2.-3
Zinc And Ring Finger 11     EC 6.3.28

External Ids:    HGNC: 184521   Entrez Gene: 849372   Ensembl: ENSG000001861877   OMIM: 6120605   UniProtKB: Q8ND253   

Export aliases for ZNRF1 gene to outside databases

Previous GC identifers: GC16P074812 GC00U917013 GC16P073590 GC16P060784


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ZNRF1 Gene:
This gene encodes an E3 ubiquitin-protein ligase that plays a role in neural-cell differentiation. Overexpression
of this gene causes neurite-like elongation. The encoded protein contains both a zinc finger and a RING finger
motif and is localized in the endosome/lysosome compartment, indicating that it may be involved in
ubiquitin-mediated protein modification, and in synaptic vessicle membranes in neurons. (provided by RefSeq, Feb
2012)

GeneCards Summary for ZNRF1 Gene:
ZNRF1 (zinc and ring finger 1, E3 ubiquitin protein ligase) is a protein-coding gene. GO annotations related to this gene include ubiquitin-protein ligase activity. An important paralog of this gene is ZNRF2.

UniProtKB/Swiss-Prot: ZNRF1_HUMAN, Q8ND25
Function: E3 ubiquitin-protein ligase that mediates the ubiquitination of AKT1 and GLUL, thereby playing a role in
neuron cells differentiation. Plays a role in the establishment and maintenance of neuronal transmission and
plasticity. Regulates Schwann cells differentiation by mediating ubiquitination of GLUL. Promotes
neurodegeneration by mediating 'Lys-48'-linked polyubiquitination and subsequent degradation of AKT1 in axons:
degradation of AKT1 prevents AKT1-mediated phosphorylation of GSK3B, leading to GSK3B activation and
phosphorylation of DPYSL2/CRMP2 followed by destabilization of microtubule assembly in axons (Probable)

Gene Wiki entry for ZNRF1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000016.9  NC_018927.2  NT_010498.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZNRF1 gene promoter:
         AML1a   AP-2gamma   Meis-1b   AREB6   STAT3   AP-2beta   Meis-1a   AP-2alpha   Meis-1   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNRF1 promoter sequence
   Search Chromatin IP Primers for ZNRF1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNRF1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q23.1   Ensembl cytogenetic band:  16q23.1   HGNC cytogenetic band: 16q22.3

ZNRF1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNRF1 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P075033:  view genomic region     (about GC identifiers)

Start:
75,032,915 bp from pter      End:
75,144,892 bp from pter
Size:
111,978 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ZNRF1_HUMAN, Q8ND25 (See protein sequence)
Recommended Name: E3 ubiquitin-protein ligase ZNRF1  
Size: 227 amino acids; 23783 Da
Subunit: Interacts with AKT1, GLUL and TUBB2A (By similarity)
Secondary accessions: D3DUJ9 Q9H083
Alternative splicing: 2 isoforms:  Q8ND25-1   Q8ND25-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ZNRF1: NX_Q8ND25

Explore proteomics data for ZNRF1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys150, Lys167
  • Modification sites at PhosphoSitePlus
  • 3 DME Specific Peptides for ZNRF1 (Q8ND25)
     CSKSVAS  QGDTIARLPCLCIYHK  HFIMCLSKPRLSYNDDVL 


    See ZNRF1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_115644.1  
    ENSEMBL proteins: 
     ENSP00000335091   ENSP00000323362   ENSP00000456168   ENSP00000455601   ENSP00000462910  
     ENSP00000457606  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RNF: RING-type (C3HC4) zinc fingers

    2 InterPro protein domains:
     IPR001841 Znf_RING
     IPR013083 Znf_RING/FYVE/PHD

    Graphical View of Domain Structure for InterPro Entry Q8ND25

    ProtoNet protein and cluster: Q8ND25

    1 Blocks protein domain: IPB001841 Zn-finger

    UniProtKB/Swiss-Prot: ZNRF1_HUMAN, Q8ND25
    Domain: The RING-type zinc finger domain is required for E3 ligase activity (By similarity)
    Similarity: Contains 1 RING-type zinc finger


    Find genes that share domains with ZNRF1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZNRF1_HUMAN, Q8ND25
    Function: E3 ubiquitin-protein ligase that mediates the ubiquitination of AKT1 and GLUL, thereby playing a role in
    neuron cells differentiation. Plays a role in the establishment and maintenance of neuronal transmission and
    plasticity. Regulates Schwann cells differentiation by mediating ubiquitination of GLUL. Promotes
    neurodegeneration by mediating 'Lys-48'-linked polyubiquitination and subsequent degradation of AKT1 in axons:
    degradation of AKT1 prevents AKT1-mediated phosphorylation of GSK3B, leading to GSK3B activation and
    phosphorylation of DPYSL2/CRMP2 followed by destabilization of microtubule assembly in axons (Probable)

         Enzyme Numbers (IUBMB): EC 6.3.2.-1 EC 6.3.22

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity ISS--
    GO:0005515protein binding IPI19549727
    GO:0008270zinc ion binding IEA--
    GO:0046872metal ion binding ----
         
    Find genes that share ontologies with ZNRF1           About GenesLikeMe


    Phenotypes:
         4 GenomeRNAi human phenotypes for ZNRF1:
     G0/1 arrest  Increased G1 DNA content  Increased cell death HMECs cel  Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ZNRF1
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    Selected qRT-PCR Assays for microRNAs that regulate ZNRF1 (see all 89):
    hsa-miR-3607-3p hsa-miR-607 hsa-miR-642a hsa-miR-1914* hsa-miR-938 hsa-miR-219-5p hsa-miR-30d hsa-miR-371-5p
    SwitchGear 3'UTR luciferase reporter plasmidZNRF1 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZNRF1_HUMAN, Q8ND25: Endosome. Lysosome. Membrane; Peripheral membrane protein. Cytoplasmic vesicle, secretory
    vesicle, synaptic vesicle membrane; Peripheral membrane protein (Potential). Note=Associated with synaptic
    vesicle membranes in neurons
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endosome5
    lysosome5
    vacuole5
    extracellular2
    mitochondrion2
    cytosol1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005764lysosome IEA--
    GO:0005768endosome IDA--
    GO:0030054cell junction IEA--
    GO:0030672synaptic vesicle membrane IEA--

    Find genes that share ontologies with ZNRF1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    UniProtKB/Swiss-Prot: ZNRF1_HUMAN, Q8ND25
    Pathway: Protein modification; protein ubiquitination

        Pathway & Disease-focused RT2 Profiler PCR Array including ZNRF1: 

              Ubiquitin Ligases in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for ZNRF1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    Selected Interacting proteins for ZNRF1 (Q8ND251, 3 ENSP000003350914) via UniProtKB, MINT, STRING, and/or I2D (see all 16)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBE2D2P628371, 3, ENSP000003817174EBI-2129250,EBI-347677 I2D: score=2 STRING: ENSP00000381717
    UBE2D3P610771, 3, ENSP000003497224EBI-2129250,EBI-348268 I2D: score=2 STRING: ENSP00000349722
    UBE2NP610881, 3, ENSP000003161764EBI-2129250,EBI-1052908 I2D: score=2 STRING: ENSP00000316176
    UBE2V1Q134041, 3, ENSP000003403054EBI-2129250,EBI-1050671 I2D: score=2 STRING: ENSP00000340305
    UBE2D1P516681, 3, ENSP000003630194EBI-2129250,EBI-743540 I2D: score=2 STRING: ENSP00000363019
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0043161proteasome-mediated ubiquitin-dependent protein catabolic process ISS--
    GO:0070936protein K48-linked ubiquitination ISS--

    Find genes that share ontologies with ZNRF1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for ZNRF1

    4 HMDB Compounds for ZNRF1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ZNRF1 gene: 
    NM_032268.4  

    Unigene Cluster for ZNRF1:

    Zinc and ring finger 1, E3 ubiquitin protein ligase
    Hs.427284  [show with all ESTs]
    Unigene Representative Sequence: NM_032268
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000335325(uc010vmz.1 uc002fdk.3 uc002fdl.1 uc010cgr.1)
    ENST00000320619 ENST00000566250 ENST00000567962 ENST00000564320 ENST00000568511
    ENST00000579084 ENST00000566244 ENST00000568351 ENST00000568494 ENST00000568844

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    Selected qRT-PCR Assays for microRNAs that regulate ZNRF1 (see all 89):
    hsa-miR-3607-3p hsa-miR-607 hsa-miR-642a hsa-miR-1914* hsa-miR-938 hsa-miR-219-5p hsa-miR-30d hsa-miR-371-5p
    SwitchGear 3'UTR luciferase reporter plasmidZNRF1 3' UTR sequence
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    Additional mRNA sequence: 

    AK027752.1 AK294434.1 AL136903.1 AL834440.1 BC007235.1 

    8 DOTS entries:

    DT.311875  DT.100792987  DT.100760151  DT.100029009  DT.100775890  DT.95279682  DT.100645627  DT.121625620 

    Selected AceView cDNA sequences (see all 234):

    BM917961 AI031696 BF432625 BM128095 AI561230 AA345830 BE500924 Z39895 
    AW105734 BE671247 BU856635 AI635536 BQ086362 BF447788 BC007235 AI144394 
    AA354443 BX104196 BU726800 AA972786 CA389198 BF063289 AI918934 BX384249 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for ZNRF1    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b
    SP1:              -     -                                             
    SP2:              -     -           -                                 
    SP3:              -     -           -                       -         
    SP4:                                -                                 
    SP5:                                                                  


    ECgene alternative splicing isoforms for ZNRF1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZNRF1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTTCTCCCTT
    ZNRF1 Expression
    About this image

    ZNRF1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZNRF1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.427284

    UniProtKB/Swiss-Prot: ZNRF1_HUMAN, Q8ND25
    Tissue specificity: Expressed primarily in the nervous system, with expression higher in developing brain relative
    to adult. Expressed at low levels in testis and thymus

        Pathway & Disease-focused RT2 Profiler PCR Array including ZNRF1: 
              Ubiquitin Ligases in human mouse rat

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    QuantiFast Probe-based Assays in human, mouse, rat ZNRF1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNRF1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ZNRF1 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Znrf11 , 5 zinc and ring finger 11, 5 95.01(n)1
    99.12(a)1
      8 (57.98 cM)5
    1707371  NM_133206.31  NP_573469.11 
     1115360975 
    chicken
    (Gallus gallus)
    Aves ZNRF11 zinc and ring finger 1, E3 ubiquitin protein ligase 84.74(n)
    90.85(a)
      425231  XM_003641904.2  XP_003641952.2 
    lizard
    (Anolis carolinensis)
    Reptilia ZNRF16
    zinc and ring finger 1, E3 ubiquitin protein ligas...
    98(a)
    1 ↔ 1
    GL343840.1(33966-34854)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC047964.12   -- 81.76(n)    BC047964.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc778962 hypothetical protein MGC77896 79.69(n)   393844  BC063239.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG144356
    --
    29(a)
    1 → many
    X(6733455-6737953)
    worm
    (Caenorhabditis elegans)
    Secernentea Y71F9AL.106
    Protein Y71F9AL.10 (Y71F9AL.10) mRNA, complete cds...
    37(a)
    1 → many
    I(2866429-2870105) WBGene00022115


    ENSEMBL Gene Tree for ZNRF1 (if available)
    TreeFam Gene Tree for ZNRF1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZNRF1 gene
    ZNRF22  
    1 SIMAP similar gene for ZNRF1 using alignment to 5 protein entries:     ZNRF1_HUMAN (see all proteins):
    ZNRF2

    Find genes that share paralogs with ZNRF1           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for ZNRF1
    PGOHUM00000238232


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZNRF1 (see all 2658)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1432654891,2
    --75030941(+) AATACC/TTGTGA 1 -- us2k10--------
    rs1475419041,2
    --75030948(+) GTGACA/GGGCTA 1 -- us2k10--------
    rs736120811,2
    C,F--75030951(+) ACGGGC/GTAGCC 1 -- us2k12Minor allele frequency- G:0.14WA 120
    rs1927410651,2
    --75031007(+) GGTCCC/TCCAGT 1 -- us2k10--------
    rs1850289611,2
    --75031010(+) CCCCCA/GGTTTA 1 -- us2k10--------
    rs1384494631,2
    --75031040(+) AATAGA/GTGGAA 1 -- us2k10--------
    rs1477937791,2
    C--75031244(+) TACAC-/ATATATA 1 -- us2k10--------
    rs97086051,2
    C,F--75031253(+) TATATA/GTATCA 1 -- us2k12Minor allele frequency- G:0.37NA EA 240
    rs2017399171,2
    --75031416(+) GGCTA-/AATT  
            
    ATTTA
    1 -- us2k10--------
    rs1386963831,2
    C--75031438(+) TTTCA-/TATTTT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ZNRF1 (75032915 - 75144892 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for ZNRF1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2714703CNV Deletion23290073
    esv1789347CNV Deletion17803354
    esv2714704CNV Deletion23290073
    esv3003CNV Deletion18987735
    nsv1878CNV Insertion18451855
    nsv833280CNV Loss17160897
    nsv906908CNV Loss21882294
    nsv103814CNV Loss16902084

    Human Gene Mutation Database (HGMD): ZNRF1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ZNRF1
    DNA2.0 Custom Variant and Variant Library Synthesis for ZNRF1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 612060    OMIM disorders: --


    Find genes that share disorders with ZNRF1           About GenesLikeMe

    Genetic Association Database (GAD): ZNRF1
    Human Genome Epidemiology (HuGE) Navigator: ZNRF1 (1 document)

    Export disorders for ZNRF1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZNRF1 gene, integrated from 10 sources (see all 19):
    (articles sorted by number of sources associating them with ZNRF1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Fine mapping and association studies of a high-density lipoprotein cholesterol linkage region on chromosome 16 in French-Canadian subjects. (PubMed id 19844255)1, 4 Dastani Z....Genest J. (Eur. J. Hum. Genet. 2010)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. ZNRF proteins constitute a family of presynaptic E3 ubiquitin ligases. (PubMed id 14561866)1, 2 Araki T. and Milbrandt J. (J. Neurosci. 2003)
    4. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (Genome Res. 2001)
    5. Identification of genes induced in peripheral nerve after injury. Expression profiling and novel gene discovery. (PubMed id 11427537)1, 2 Araki T.... Milbrandt J. (J. Biol. Chem. 2001)
    6. Multidimensional prognostic risk assessment identifies association between IL12B variation and surgery in Crohn's disease. (PubMed id 23665963)1 Dubinsky M.C....McGovern D.P. (Inflamm. Bowel Dis. 2013)
    7. ZNRF2 is released from membranes by growth factors and, together with ZNRF1, regulates the Na+/K+ATPase. (PubMed id 22797923)1 Hoxhaj G....MacKintosh C. (J. Cell. Sci. 2012)
    8. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    9. Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network. (PubMed id 19549727)1 Markson G....Sanderson C.M. (Genome Res. 2009)
    10. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (Sci. Signal. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 84937 HGNC: 18452 AceView: ZNRF1 Ensembl:ENSG00000186187 euGenes: HUgn84937
    ECgene: ZNRF1 H-InvDB: ZNRF1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZNRF1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZNRF1 gene:
    Search GeneIP for patents involving ZNRF1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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