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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZNRD1-AS1 Gene

RNA gene   GIFtS: 28
GCID: GC06M029995

ZNRD1 Antisense RNA 1

(Previous names: chromosome 6 open reading frame 12, non-protein coding RNA...)
(Previous symbols: C6orf12, NCRNA00171, ZNRD1AS, ZNRD1-AS)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Subcategory (RNA class): lncRNA

Quality score for this RNA gene is 8

Aliases
ZNRD1 Antisense RNA 11 2 3     Chromosome 6 Open Reading Frame 121
C6orf121 2 3     Non-Protein Coding RNA 1711
NCRNA001711 2 3     ZNRD1 Antisense RNA (Non-Protein Coding)1
ZNRD1-AS1 2     ZNRD1 Antisense RNA 1 (Non-Protein Coding)1
ZNRD1AS1 2     Protein HTEX43
HTEX42 3     ZNRD1 Antisense Gene Protein 13

External Ids:    HGNC: 139241   Entrez Gene: 808622   Ensembl: ENSG000002046237   UniProtKB: Q2KJ033   
ORGUL members:         
NONCODE14:n387545 n407517 n368810 n369431 n407511 see all 54      

Export aliases for ZNRD1-AS1 gene to outside databases

Previous GC identifers: GC06M029771 GC06M029979 GC06M029981 GC06M029987 GC06M029993


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ZNRD1-AS1 Gene: 
ZNRD1-AS1 (ZNRD1 antisense RNA 1) is an RNA gene, and is affiliated with the lncRNA class. Diseases associated with ZNRD1-AS1 include systemic lupus erythematosus, and lupus erythematosus.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.2  NT_007592.15  NT_113891.2  NT_167244.1  NT_167245.1  NT_167246.1  NT_167247.1  
NT_167248.1  NT_167249.1  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for ZNRD1-AS1
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for ZNRD1-AS1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNRD1-AS1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p22.1   Ensembl cytogenetic band:  6p22.1   HGNC cytogenetic band: 6p21.33

ZNRD1-AS1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNRD1-AS1 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M029995:  view genomic region     (about GC identifiers)

Start:
29,968,788 bp from pter      End:
30,029,417 bp from pter
Size:
60,630 bases      Orientation:
minus strand

6/7 alternative locations (see all 7):
Chr6-,NT_167246 1,267,361-1,327,558      Chr6-,NT_167244 1,208,891-1,269,198      Chr6-,NT_167249 1,299,109-1,359,404     
Chr6-,NT_167248 1,261,702-1,321,962      Chr6-,NT_167247 1,350,652-1,410,862      Chr6-,NT_167245 1,262,386-1,322,691     
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for ZNRD1-AS1

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZRAS1_HUMAN, Q2KJ03 (See protein sequence)
Recommended Name: Putative uncharacterized protein ZNRD1-AS1  
Size: 187 amino acids; 22371 Da
Caution: Product of a dubious CDS prediction
Alternative splicing: 2 isoforms:  Q2KJ03-1   Q2KJ03-2   

Explore the universe of human proteins at neXtProt for ZNRD1-AS1: NX_Q2KJ03

ZNRD1-AS1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 : --

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
LNCRNA: Long non-coding RNAs

ProtoNet protein and cluster: Q2KJ03


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Animal Models:
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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNRD1-AS1

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ZNRD1-AS1 (ZRAS1)

Search CenterWatch for drugs/clinical trials and news about ZNRD1-AS1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

Unigene Cluster for ZNRD1-AS1:

ZNRD1 antisense RNA 1
Hs.653168  [show with all ESTs]
Unigene Representative Sequence: CR933629
10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000425604 ENST00000448093 ENST00000376797 ENST00000420251(uc011dme.2)
ENST00000444051 ENST00000437417 ENST00000422224 ENST00000421692(uc003nox.1)
ENST00000431012(uc003rto.3) ENST00000452229
miRNA
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Inhib. RNA
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Additional mRNA sequence: 

AF032109.2 AF032110.1 AF032111.1 AF238323.1 AK055123.1 AK126001.1 BC034573.1 BC036766.1 
BC067890.1 BX648746.1 CR933629.1 L19689.1 L19692.1 NR_026751.1 

24 DOTS entries:

DT.95367099  DT.92016298  DT.92004981  DT.121346042  DT.402222  DT.101968978  DT.311764  DT.95228016 
DT.100711700  DT.121346167  DT.121346217  DT.40231607  DT.91783965  DT.97823698  DT.121345698  DT.40114307 
DT.454677  DT.91992374  DT.100733373  DT.100844024  DT.121346173  DT.121346203  DT.121346290  DT.91806393 

24/29 AceView cDNA sequences (see all 29):

CR611202 L19693 AF032110 AW117311 BC034573 AF032109 BQ423269 CA488670 
AL547982 BE744018 BU603207 X90532 AK126001 BF343945 AF238323 AL572723 
BI827073 BQ434771 BX648746 AF032111 AL705833 BX327835 AW890647 BC067890 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

Expression evidence for ZNRD1-AS1:NONCODE

ZNRD1-AS1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: ATTATTTATT
ZNRD1-AS1 Expression
About this image


Genevestigator expression for ZNRD1-AS1

SOURCE GeneReport for Unigene cluster: Hs.653168

UniProtKB/Swiss-Prot: ZRAS1_HUMAN, Q2KJ03
Tissue specificity: Widely expressed at low levels, including testis

    SABiosciences Custom PCR Arrays for ZNRD1-AS1
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNRD1-AS1

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of human and mouse.

Orthologs for ZNRD1-AS1 gene from 1 species (see representative species )    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Znrd1as5 ZNRD1 antisense RNA   --   17 (19.16 cM) 36958592 


ENSEMBL Gene Tree for ZNRD1-AS1 (if available)
TreeFam Gene Tree for ZNRD1-AS1 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/1292 SNPs in ZNRD1-AS1 are shown (see all 1292)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 6 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs92610631,2
C,F--29968306(+) GGTCTG/TGCCAA 1 -- int14Minor allele frequency- T:0.07CSA NA EA 244
rs623887301,2
--29968357(+) ACTGGA/TAGAGC 1 -- int10--------
rs92610641,2
C,F,H--29968374(+) ATAAAA/C/GCCCCG 1 -- int18NS EA CSA WA NA 778
rs1161393481,2
F--29968379(+) GCCCCG/AGGCAC 1 -- int11Minor allele frequency- A:0.03NA 120
rs92610651,2
C,F--29968394(+) TGTGCC/AGCTGT 1 -- int12Minor allele frequency- A:0.07NA EA 240
rs92610661,2
C--29968407(+) ATTTGG/ATGAGT 1 -- int13Minor allele frequency- A:0.06CSA NA EA 242
rs1897680311,2
--29968414(+) GAGTGC/TATTCC 1 -- int10--------
rs3569611,2
C,F,A,H--29968426(-) TTggaG/Atggaa 1 -- int16Minor allele frequency- A:0.26NA WA EA 364
rs109470421,2
C,F,A,H--29968455(+) ctgggC/Tgcagt 1 -- int17Minor allele frequency- T:0.18NA WA EA 366
rs92610671,2
C,F--29968457(+) gggcgC/Tagtag 1 -- int12Minor allele frequency- T:0.05WA NA 238

HapMap Linkage Disequilibrium report for ZNRD1-AS1 (29968788 - 30029417 bp)

Structural Variations
     Database of Genomic Variants (DGV) 10/15 variations for ZNRD1-AS1 (see all 15):    About this table     
Variant IDTypeSubtypePubMed ID
dgv1040e201CNV Deletion23290073
esv2731778CNV Deletion23290073
esv2641340CNV Deletion19546169
esv2731777CNV Deletion23290073
esv2670487CNV Deletion23128226
dgv1088e199CNV Deletion23128226
esv270150CNV Insertion20981092
esv1527047CNV Insertion17803354
esv272388CNV Insertion20981092
dgv6517n71CNV Loss21882294

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
2 diseases for ZNRD1-AS1:    About MalaCards
systemic lupus erythematosus    lupus erythematosus


ZNRD1-AS1 for disorders           About GeneDecksing


Export disorders for ZNRD1-AS1 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for ZNRD1-AS1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ZNRD1-AS1)
    Utopia: connect your pdf to the dynamic
world of online information

  1. HTEX4, a new human gene in the MHC class I region, undergoes alternative splicing and polyadenylation processes in testis. (PubMed id 9553157)1, 2, 3 Lepourcelet M....Mosser J. (1998)
  2. Transcriptional analysis of the 69-kb sequence centromeric to HLA-J: a dense and complex structure of five genes. (PubMed id 11130983)1, 3 Coriton O.... Mosser J. (2000)
  3. Genome-wide association study identifies multiple loci influencing human serum metabolite levels. (PubMed id 22286219)1 Kettunen J....Ripatti S. (2012)
  4. Identification of independent risk loci for Graves' di sease within the MHC in the Japanese population. (PubMed id 21900946)1 Nakabayashi K....Shirasawa S. (2011)
  5. High-density SNP screening of the major histocompatib ility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PubMed id 19851445)1 Barcellos L.F....Criswell L.A. (2009)
  6. Common genetic variation and the control of HIV-1 in humans. (PubMed id 20041166)1 Fellay J....Goldstein D.B. (2009)
  7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
  8. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)2 Mungall A.J.... Beck S. (2003)
  9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 80862 HGNC: 13924 AceView: C6orf12andHCP5P2 Ensembl:ENSG00000204623 euGenes: HUgn80862
ECgene: ZNRD1-AS1 H-InvDB: ZNRD1-AS1

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for ZNRD1-AS1 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for ZNRD1-AS1 gene:
Search GeneIP for patents involving ZNRD1-AS1

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

 
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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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