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Aliases for ZNRD1 Gene

Aliases for ZNRD1 Gene

  • Zinc Ribbon Domain Containing 1 2 3
  • Rpa12 3 4
  • RNA Polymerase I Small Specific Subunit Rpa12 3
  • Transcription-Associated Zinc Ribbon Protein 3
  • Zinc Ribbon Domain-Containing Protein 1 4
  • Zinc Ribbon Domain Containing, 1 2
  • Tctex-6 3
  • HTEX-6 3
  • TCTEX6 3
  • HTEX6 3
  • HZR14 3
  • TEX6 3
  • ZR14 3

External Ids for ZNRD1 Gene

Previous GeneCards Identifiers for ZNRD1 Gene

  • GC06P030085
  • GC06P029799
  • GC06P030135
  • GC06P030137
  • GC06P030026
  • GC06P030233

Summaries for ZNRD1 Gene

Entrez Gene Summary for ZNRD1 Gene

  • This gene encodes a DNA-directed RNA polymerase I subunit. The encoded protein contains two potential zinc-binding motifs and may play a role in regulation of cell proliferation. The encoded protein may be involved in cancer and human immunodeficiency virus progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

GeneCards Summary for ZNRD1 Gene

ZNRD1 (Zinc Ribbon Domain Containing 1) is a Protein Coding gene. Among its related pathways are Metabolism and Gene Expression. GO annotations related to this gene include nucleic acid binding and RNA polymerase I activity.

UniProtKB/Swiss-Prot for ZNRD1 Gene

  • DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors

Gene Wiki entry for ZNRD1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNRD1 Gene

Genomics for ZNRD1 Gene

Regulatory Elements for ZNRD1 Gene

Genomic Location for ZNRD1 Gene

Chromosome:
6
Start:
30,058,899 bp from pter
End:
30,064,909 bp from pter
Size:
6,011 bases
Orientation:
Plus strand

Genomic View for ZNRD1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNRD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for ZNRD1 Gene

  • Protein details for ZNRD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P1U0-RPA12_HUMAN
    Recommended name:
    DNA-directed RNA polymerase I subunit RPA12
    Protein Accession:
    Q9P1U0

    Protein attributes for ZNRD1 Gene

    Size:
    126 amino acids
    Molecular mass:
    13904 Da
    Quaternary structure:
    • Component of the RNA polymerase I (Pol I) complex consisting of at least 13 subunits.

neXtProt entry for ZNRD1 Gene

Proteomics data for ZNRD1 Gene at MOPED

Post-translational modifications for ZNRD1 Gene

No Post-translational modifications

Other Protein References for ZNRD1 Gene

Antibody Products

No data available for DME Specific Peptides for ZNRD1 Gene

Domains & Families for ZNRD1 Gene

Suggested Antigen Peptide Sequences for ZNRD1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9P1U0

UniProtKB/Swiss-Prot:

RPA12_HUMAN :
  • Belongs to the archaeal RpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.
  • Contains 1 TFIIS-type zinc finger.
Family:
  • Belongs to the archaeal RpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.
Similarity:
  • Contains 1 TFIIS-type zinc finger.
genes like me logo Genes that share domains with ZNRD1: view

No data available for Gene Families for ZNRD1 Gene

Function for ZNRD1 Gene

Molecular function for ZNRD1 Gene

UniProtKB/Swiss-Prot Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors

Gene Ontology (GO) - Molecular Function for ZNRD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001054 contributes_to RNA polymerase I activity IBA --
GO:0003676 nucleic acid binding IEA --
GO:0003899 DNA-directed RNA polymerase activity --
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with ZNRD1: view
genes like me logo Genes that share phenotypes with ZNRD1: view

Animal Model Products

miRNA for ZNRD1 Gene

miRTarBase miRNAs that target ZNRD1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNRD1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNRD1 Gene

Localization for ZNRD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNRD1 Gene

Nucleus, nucleolus.

Gene Ontology (GO) - Cellular Components for ZNRD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0005736 DNA-directed RNA polymerase I complex IBA --
genes like me logo Genes that share ontologies with ZNRD1: view

No data available for Subcellular locations from COMPARTMENTS for ZNRD1 Gene

Pathways & Interactions for ZNRD1 Gene

genes like me logo Genes that share pathways with ZNRD1: view

Interacting Proteins for ZNRD1 Gene

Gene Ontology (GO) - Biological Process for ZNRD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006139 nucleobase-containing compound metabolic process TAS 10662553
GO:0006351 transcription, DNA-templated --
GO:0006360 transcription from RNA polymerase I promoter TAS --
GO:0006361 transcription initiation from RNA polymerase I promoter TAS --
GO:0006362 transcription elongation from RNA polymerase I promoter TAS --
genes like me logo Genes that share ontologies with ZNRD1: view

No data available for SIGNOR curated interactions for ZNRD1 Gene

Drugs & Compounds for ZNRD1 Gene

(7) Drugs for ZNRD1 Gene - From: HMDB and NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
Vincristine Approved, Investigational Pharma Microtubule disrupter,antitumor agent 836
Zinc Approved Pharma 1404
Cytidine triphosphate Experimental Pharma 0
Diphosphate Experimental Pharma 0

(2) Additional Compounds for ZNRD1 Gene - From: HMDB and NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
Adriamycin
genes like me logo Genes that share compounds with ZNRD1: view

Transcripts for ZNRD1 Gene

mRNA/cDNA for ZNRD1 Gene

(4) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(11) Selected AceView cDNA sequences:
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNRD1 Gene

Zinc ribbon domain containing 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNRD1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNRD1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c
SP1: -
SP2:
SP3: - -
SP4:
SP5: - -
SP6:

Relevant External Links for ZNRD1 Gene

GeneLoc Exon Structure for
ZNRD1
ECgene alternative splicing isoforms for
ZNRD1

Expression for ZNRD1 Gene

mRNA expression in normal human tissues for ZNRD1 Gene

Protein differential expression in normal tissues from HIPED for ZNRD1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (37.4) and Fetal ovary (31.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZNRD1 Gene



SOURCE GeneReport for Unigene cluster for ZNRD1 Gene Hs.57813

genes like me logo Genes that share expression patterns with ZNRD1: view

Protein tissue co-expression partners for ZNRD1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNRD1 Gene

Orthologs for ZNRD1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ZNRD1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ZNRD1 35
  • 89.43 (n)
  • 88.62 (a)
ZNRD1 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZNRD1 35
  • 80.95 (n)
  • 77.78 (a)
ZNRD1 36
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Znrd1 35
  • 80.76 (n)
  • 82.11 (a)
Znrd1 16
Znrd1 36
  • 82 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ZNRD1 35
  • 100 (n)
  • 100 (a)
ZNRD1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Znrd1 35
  • 82.66 (n)
  • 83.74 (a)
oppossum
(Monodelphis domestica)
Mammalia ZNRD1 36
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZNRD1 36
  • 26 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZNRD1 36
  • 59 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.20223 35
znrd1 35
  • 65.29 (n)
  • 66.94 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.33613 35
zebrafish
(Danio rerio)
Actinopterygii znrd1 35
  • 62.36 (n)
  • 57.76 (a)
znrd1 36
  • 54 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1899 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002375 35
  • 53.15 (n)
  • 41.44 (a)
fruit fly
(Drosophila melanogaster)
Insecta RpI12 35
  • 47.86 (n)
  • 40.17 (a)
RpI12 36
  • 39 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea rpoa-12 36
  • 39 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPA12 36
  • 34 (a)
OneToOne
RPA12 38
Species with no ortholog for ZNRD1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZNRD1 Gene

ENSEMBL:
Gene Tree for ZNRD1 (if available)
TreeFam:
Gene Tree for ZNRD1 (if available)

Paralogs for ZNRD1 Gene

No data available for Paralogs for ZNRD1 Gene

Variants for ZNRD1 Gene

Sequence variations from dbSNP and Humsavar for ZNRD1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
VAR_052287 -

Structural Variations from Database of Genomic Variants (DGV) for ZNRD1 Gene

Variant ID Type Subtype PubMed ID
esv2731777 CNV Deletion 23290073

Variation tolerance for ZNRD1 Gene

Residual Variation Intolerance Score: 64.03% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.65; 45.62% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNRD1 Gene

HapMap Linkage Disequilibrium report
ZNRD1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNRD1 Gene

Disorders for ZNRD1 Gene

Relevant External Links for ZNRD1

Genetic Association Database (GAD)
ZNRD1
Human Genome Epidemiology (HuGE) Navigator
ZNRD1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNRD1
genes like me logo Genes that share disorders with ZNRD1: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNRD1 Gene

Publications for ZNRD1 Gene

  1. A new zinc ribbon gene (ZNRD1) is cloned from the human MHC class I region. (PMID: 10662553) Fan W. … Lennon G. (Genomics 2000) 2 23 67
  2. ZNRD1 mediates resistance of gastric cancer cells to methotrexate by regulation of IMPDH2 and Bcl-2. (PMID: 16609701) Hong L. … Fan D. (Biochem. Cell Biol. 2006) 23 67
  3. Zinc ribbon domain-containing 1 (ZNRD1) mediates multidrug resistance of leukemia cells through regulation of P-glycoprotein and Bcl-2. (PMID: 16373708) Hong L. … Fan D. (Mol. Cancer Ther. 2005) 23 67
  4. ZNRD1 gene suppresses cell proliferation through cell cycle arrest in G1 phase. (PMID: 15662122) Hong L. … Fan D. (Cancer Biol. Ther. 2005) 23 67
  5. Overexpression of ZNRD1 promotes multidrug-resistant phenotype of gastric cancer cells through upregulation of P-glycoprotein. (PMID: 14726695) Shi Y. … Fan D. (Cancer Biol. Ther. 2004) 23 67

Products for ZNRD1 Gene

Sources for ZNRD1 Gene

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