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Aliases for ZNRD1 Gene

Aliases for ZNRD1 Gene

  • Zinc Ribbon Domain Containing 1 2 3
  • Rpa12 3 4
  • RNA Polymerase I Small Specific Subunit Rpa12 3
  • Transcription-Associated Zinc Ribbon Protein 3
  • DNA-Directed RNA Polymerase I Subunit RPA12 3
  • Zinc Ribbon Domain-Containing Protein 1 4
  • Zinc Ribbon Domain Containing, 1 2
  • Tctex-6 3
  • HTEX-6 3
  • TCTEX6 3
  • HTEX6 3
  • HZR14 3
  • TEX6 3
  • ZR14 3

External Ids for ZNRD1 Gene

Summaries for ZNRD1 Gene

Entrez Gene Summary for ZNRD1 Gene

  • This gene encodes a DNA-directed RNA polymerase I subunit. The encoded protein contains two potential zinc-binding motifs and may play a role in regulation of cell proliferation. The encoded protein may be involved in cancer and human immunodeficiency virus progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

GeneCards Summary for ZNRD1 Gene

ZNRD1 (Zinc Ribbon Domain Containing 1) is a Protein Coding gene. Diseases associated with ZNRD1 include esophageal cancer and stomach cancer. Among its related pathways are Metabolism and Purine metabolism (KEGG). GO annotations related to this gene include nucleic acid binding and DNA-directed RNA polymerase activity.

UniProtKB/Swiss-Prot for ZNRD1 Gene

  • DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors

Gene Wiki entry for ZNRD1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNRD1 Gene

Genomics for ZNRD1 Gene

Genomic Location for ZNRD1 Gene

Start:
30,058,899 bp from pter
End:
30,064,909 bp from pter
Size:
6,011 bases
Orientation:
Plus strand

Genomic View for ZNRD1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNRD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Regulatory Elements for ZNRD1 Gene

Proteins for ZNRD1 Gene

  • Protein details for ZNRD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P1U0-RPA12_HUMAN
    Recommended name:
    DNA-directed RNA polymerase I subunit RPA12
    Protein Accession:
    Q9P1U0
    Secondary Accessions:

    Protein attributes for ZNRD1 Gene

    Size:
    126 amino acids
    Molecular mass:
    13904 Da
    Quaternary structure:
    • Component of the RNA polymerase I (Pol I) complex consisting of at least 13 subunits.

neXtProt entry for ZNRD1 Gene

Proteomics data for ZNRD1 Gene at MOPED

Post-translational modifications for ZNRD1 Gene

No Post-translational modifications

Other Protein References for ZNRD1 Gene

No data available for DME Specific Peptides for ZNRD1 Gene

Domains for ZNRD1 Gene

UniProtKB/Swiss-Prot:

RPA12_HUMAN
Family:
  • Belongs to the archaeal RpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.:
    • Q9P1U0
Similarity:
  • Contains 1 TFIIS-type zinc finger.:
    • Q9P1U0
genes like me logo Genes that share domains with ZNRD1: view

No data available for Gene Families for ZNRD1 Gene

Function for ZNRD1 Gene

Molecular function for ZNRD1 Gene

UniProtKB/Swiss-Prot Function: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors

Gene Ontology (GO) - Molecular Function for ZNRD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001054 contributes_to RNA polymerase I activity IBA --
GO:0003676 nucleic acid binding IEA --
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with ZNRD1: view

Phenotypes for ZNRD1 Gene

genes like me logo Genes that share phenotypes with ZNRD1: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ZNRD1 Gene

Localization for ZNRD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNRD1 Gene

Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNRD1 Gene COMPARTMENTS Subcellular localization image for ZNRD1 gene
Compartment Confidence
extracellular 3
nucleus 2
cytosol 1

Gene Ontology (GO) - Cellular Components for ZNRD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0005736 DNA-directed RNA polymerase I complex IBA --
genes like me logo Genes that share ontologies with ZNRD1: view

Pathways for ZNRD1 Gene

genes like me logo Genes that share pathways with ZNRD1: view

Pathways by source for ZNRD1 Gene

Interacting Proteins for ZNRD1 Gene

Gene Ontology (GO) - Biological Process for ZNRD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006139 nucleobase-containing compound metabolic process TAS 10662553
GO:0006351 transcription, DNA-templated --
GO:0006360 transcription from RNA polymerase I promoter TAS --
GO:0006361 transcription initiation from RNA polymerase I promoter TAS --
GO:0006362 transcription elongation from RNA polymerase I promoter TAS --
genes like me logo Genes that share ontologies with ZNRD1: view

Compounds for ZNRD1 Gene

(6) HMDB Compounds for ZNRD1 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
Cytidine triphosphate
  • cytidine 5'-(tetrahydrogen triphosphate)
65-47-4
Guanosine triphosphate
  • 5'-GTP
86-01-1
Phosphoric acid
  • acide phosphorique (FRENCH)
7664-38-2
Pyrophosphate
  • (4-)Diphosphoric acid ion
14000-31-8

(3) Novoseek inferred chemical compound relationships for ZNRD1 Gene

Compound -log(P) Hits PubMed IDs
zinc 53.6 6
adriamycin 51.7 3
vincristine 49.3 3
genes like me logo Genes that share compounds with ZNRD1: view

Transcripts for ZNRD1 Gene

mRNA/cDNA for ZNRD1 Gene

(4) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(11) Selected AceView cDNA sequences:
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNRD1 Gene

Zinc ribbon domain containing 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNRD1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c
SP1: -
SP2:
SP3: - -
SP4:
SP5: - -
SP6:

Relevant External Links for ZNRD1 Gene

GeneLoc Exon Structure for
ZNRD1
ECgene alternative splicing isoforms for
ZNRD1

Expression for ZNRD1 Gene

mRNA expression in normal human tissues for ZNRD1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZNRD1 Gene

SOURCE GeneReport for Unigene cluster for ZNRD1 Gene Hs.57813

genes like me logo Genes that share expressions with ZNRD1: view

Orthologs for ZNRD1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ZNRD1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNRD1 36
  • 100 (n)
  • 100 (a)
ZNRD1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZNRD1 36
  • 89.43 (n)
  • 88.62 (a)
ZNRD1 37
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZNRD1 36
  • 80.95 (n)
  • 77.78 (a)
ZNRD1 37
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Znrd1 36
  • 80.76 (n)
  • 82.11 (a)
Znrd1 16
Znrd1 37
  • 82 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZNRD1 37
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZNRD1 37
  • 26 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Znrd1 36
  • 82.66 (n)
  • 83.74 (a)
lizard
(Anolis carolinensis)
Reptilia ZNRD1 37
  • 59 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.33613 36
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.20223 36
znrd1 36
  • 65.29 (n)
  • 66.94 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1899 36
zebrafish
(Danio rerio)
Actinopterygii znrd1 36
  • 62.36 (n)
  • 57.76 (a)
znrd1 37
  • 54 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002375 36
  • 53.15 (n)
  • 41.44 (a)
fruit fly
(Drosophila melanogaster)
Insecta RpI12 36
  • 47.86 (n)
  • 40.17 (a)
RpI12 37
  • 39 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea rpoa-12 37
  • 39 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPA12 37
  • 34 (a)
OneToOne
RPA12 39
Species with no ortholog for ZNRD1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZNRD1 Gene

ENSEMBL:
Gene Tree for ZNRD1 (if available)
TreeFam:
Gene Tree for ZNRD1 (if available)

Paralogs for ZNRD1 Gene

No data available for Paralogs for ZNRD1 Gene

Variants for ZNRD1 Gene

Sequence variations from dbSNP and Humsavar for ZNRD1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs1150739 -- 30,063,568(-) attat(A/G)agaca intron-variant
rs9261276 -- 30,063,282(+) TCCTC(C/T)ATTTC intron-variant
rs9261277 -- 30,063,314(+) TCAAT(C/T)GCTGT intron-variant
rs9261278 -- 30,063,585(+) atctg(C/T)ggatt intron-variant
rs9280880 -- 30,064,306(+) AAAAA(A/T)TTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNRD1 Gene

Variant ID Type Subtype PubMed ID
esv2731777 CNV Deletion 23290073

Relevant External Links for ZNRD1 Gene

HapMap Linkage Disequilibrium report
ZNRD1

Disorders for ZNRD1 Gene

(1) Novoseek inferred disease relationships for ZNRD1 Gene

Disease -log(P) Hits PubMed IDs
gastric cancer 59.6 15

Relevant External Links for ZNRD1

Genetic Association Database (GAD)
ZNRD1
Human Genome Epidemiology (HuGE) Navigator
ZNRD1
genes like me logo Genes that share disorders with ZNRD1: view

No data available for UniProtKB/Swiss-Prot for ZNRD1 Gene

Publications for ZNRD1 Gene

  1. A new zinc ribbon gene (ZNRD1) is cloned from the human MHC class I region. (PMID: 10662553) Fan W. … Lennon G. (Genomics 2000) 2 3 4 23
  2. Overexpression of ZNRD1 promotes multidrug-resistant phenotype of gastric cancer cells through upregulation of P-glycoprotein. (PMID: 14726695) Shi Y. … Fan D. (Cancer Biol. Ther. 2004) 3 23
  3. Suppression of the cell proliferation in stomach cancer cells by the ZNRD1 gene. (PMID: 15358150) Hong L. … Fan D. (Biochem. Biophys. Res. Commun. 2004) 3 23
  4. ZNRD1 gene suppresses cell proliferation through cell cycle arrest in G1 phase. (PMID: 15662122) Hong L. … Fan D. (Cancer Biol. Ther. 2005) 3 23
  5. Systematic sequencing of the human HLA-A/HLA-F region: establishment of a cosmid contig and identification of a new gene cluster within 37 kb of sequence. (PMID: 8938444) Lepourcelet M. … Mosser J. (Genomics 1996) 2 3

Products for ZNRD1 Gene

  • antibodies-online proteins for ZNRD1
  • antibodies-online antibodies for ZNRD1
  • antibodies-online kits for ZNRD1

Sources for ZNRD1 Gene

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