Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZNRD1 Gene

protein-coding   GIFtS: 56
GCID: GC06P030026

Zinc Ribbon Domain Containing 1

(Previous names: zinc ribbon domain containing, 1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Zinc Ribbon Domain Containing 11 2     hZR142
Zinc Ribbon Domain Containing, 11     RNA Polymerase I Small Specific Subunit Rpa122
HTEX-62     tctex-62
Rpa122     Transcription-Associated Zinc Ribbon Protein2
TEX62     RPA123
ZR142     Zinc Ribbon Domain-Containing Protein 13
DNA-Directed RNA Polymerase I Subunit RPA122     

External Ids:    HGNC: 131821   Entrez Gene: 308342   Ensembl: ENSG000000663797   OMIM: 6075255   UniProtKB: Q9P1U03   

Export aliases for ZNRD1 gene to outside databases

Previous GC identifers: GC06P030085 GC06P029799 GC06P030135 GC06P030137


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ZNRD1 Gene:
This gene encodes a DNA-directed RNA polymerase I subunit. The encoded protein contains two potential zinc-binding
motifs and may play a role in regulation of cell proliferation. The encoded protein may be involved in cancer and
human immunodeficiency virus progression. Alternative splicing results in multiple transcript variants. (provided
by RefSeq, Jul 2013)

GeneCards Summary for ZNRD1 Gene: 
ZNRD1 (zinc ribbon domain containing 1) is a protein-coding gene. Diseases associated with ZNRD1 include stomach cancer, and gastric adenocarcinoma, and among its related super-pathways are Pyrimidine metabolism and RNA Polymerase III Chain Elongation. GO annotations related to this gene include DNA-directed RNA polymerase activity and nucleic acid binding.

UniProtKB/Swiss-Prot: RPA12_HUMAN, Q9P1U0
Function: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside
triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors

Gene Wiki entry for ZNRD1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.2  NT_007592.15  NT_113891.2  NT_167244.1  NT_167245.1  NT_167246.1  NT_167247.1  
NT_167248.1  NT_167249.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZNRD1 gene promoter:
         AREB6   Pax-3   AML1a   Bach2   FOXO3a   FOXO3   Nkx2-5   FOXO3b   Arnt   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNRD1 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZNRD1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNRD1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.3   Ensembl cytogenetic band:  6p22.1   HGNC cytogenetic band: 6p21

ZNRD1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNRD1 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P030026:  view genomic region     (about GC identifiers)

Start:
30,026,676 bp from pter      End:
30,032,686 bp from pter
Size:
6,011 bases      Orientation:
plus strand

6/7 alternative locations (see all 7):
Chr6+,NT_167244 1,269,273-1,272,917      Chr6+,NT_167248 1,322,037-1,325,666      Chr6+,NT_167246 1,327,633-1,331,278     
Chr6+,NT_167247 1,410,937-1,414,584      Chr6+,NT_167249 1,359,479-1,363,126      Chr6+,NT_167245 1,322,766-1,326,410     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RPA12_HUMAN, Q9P1U0 (See protein sequence)
Recommended Name: DNA-directed RNA polymerase I subunit RPA12  
Size: 126 amino acids; 13904 Da
Subunit: Component of the RNA polymerase I (Pol I) complex consisting of at least 13 subunits (By similarity)
Subcellular location: Nucleus, nucleolus (By similarity)

Explore the universe of human proteins at neXtProt for ZNRD1: NX_Q9P1U0

Explore proteomics data for ZNRD1 at MOPED 

ZNRD1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

ZNRD1 Protein Expression

REFSEQ proteins (4 alternative transcripts): 
NP_001265714.1  NP_001265715.1  NP_055411.1  NP_740753.1  

ENSEMBL proteins: 
 ENSP00000331111   ENSP00000365978   ENSP00000352333   ENSP00000365981  

Human Recombinant Protein Products for ZNRD1: 
Browse Purified and Recombinant Proteins at EMD Millipore
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
OriGene Purified Protein for ZNRD1
OriGene Protein Over-expression Lysate for ZNRD1
OriGene MassSpec for ZNRD1 
OriGene Custom Protein Services for ZNRD1
GenScript Custom Purified and Recombinant Proteins Services for ZNRD1
Novus Biologicals ZNRD1 Proteins
Novus Biologicals ZNRD1 Lysates
Browse Sino Biological Recombinant Proteins
Browse Sino Biological Cell Lysates 
Browse ProSpec Recombinant Proteins
Cloud-Clone Corp. Proteins for ZNRD1 

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005730nucleolus IEA--

ZNRD1 for ontologies           About GeneDecksing



ZNRD1 Antibody Products: 
Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Browse R&D Systems for Antibodies
OriGene Antibodies for ZNRD1
OriGene Custom Antibody Services for ZNRD1
GenScript Custom Superior Antibodies Services for ZNRD1
Novus Biologicals ZNRD1 Antibodies
Abcam antibodies for ZNRD1
Cloud-Clone Corp. Antibodies for ZNRD1 
Search ThermoFisher Antibodies for ZNRD1
LSBio Antibodies in human, mouse, rat for ZNRD1 

Assay Products for ZNRD1: 
Browse Kits and Assays available from EMD Millipore
OriGene Custom Assay Services for ZNRD1
Browse R&D Systems for biochemical assays
GenScript Custom Assay Services for ZNRD1
Browse Enzo Life Sciences for kits & assays
Cloud-Clone Corp. ELISAs for ZNRD1 
Cloud-Clone Corp. CLIAs for ZNRD1


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
3 InterPro protein domains:
 IPR001222 Znf_TFIIS
 IPR012164 DNA-dir_RNApol_C11
 IPR019761 DNA-dir_RNA_pol-M_15_CS

Graphical View of Domain Structure for InterPro Entry Q9P1U0

ProtoNet protein and cluster: Q9P1U0

1 Blocks protein domain: IPB001529 DNA-directed RNA polymerase

UniProtKB/Swiss-Prot: RPA12_HUMAN, Q9P1U0
Similarity: Belongs to the archaeal RpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family
Similarity: Contains 1 TFIIS-type zinc finger


ZNRD1 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: RPA12_HUMAN, Q9P1U0
Function: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside
triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors

     Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003676nucleic acid binding IEA--
GO:0003899DNA-directed RNA polymerase activity IEA--
GO:0008270zinc ion binding IEA--
     
ZNRD1 for ontologies           About GeneDecksing


Phenotypes:
     2 GenomeRNAi human phenotypes for ZNRD1:
 Decreased Tat-dependent transc  Decreased p24 protein expressi 

Animal Models:
   inGenious Targeting Laboratory - Custom generated mouse model solutions for ZNRD1 
   inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ZNRD1

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ZNRD1 
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ZNRD1 

miRNA
Products:
    
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ZNRD1
Search QIAGEN for miScript miRNA Assays for microRNAs that regulate ZNRD1
SwitchGear 3'UTR luciferase reporter plasmidZNRD1 3' UTR sequence
Inhib. RNA
Products:
    
Browse for Gene Knock-down Tools from EMD Millipore
OriGene RNAi products in human, mouse, rat for ZNRD1
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZNRD1

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for ZNRD1
Sirion Biotech Customized adenovirus for overexpression of ZNRD1

Clone
Products:
     
Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
OriGene clones in human, mouse for ZNRD1 (see all 13)
OriGene ORF clones in mouse, rat for ZNRD1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector (see all 2): ZNRD1 (NM_014596)
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for ZNRD1
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNRD1
Sirion Biotech Customized lentivirus for stable overexpression of ZNRD1 
                     Customized lentivirus expression plasmids for stable overexpression of ZNRD1 

Cell Line
Products:
     
GenScript Custom overexpressing Cell Line Services for ZNRD1
Search LifeMap BioReagents cell lines for ZNRD1
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNRD1


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for ZNRD1 About                                                                                                See pathways by source

SuperPathContained pathways About
1Purine metabolism
Purine metabolism0.38
Pyrimidine metabolism0.38
2RNA Polymerase III Transcription Initiation
RNA polymerase0.50
3Metabolism
Metabolic pathways0.40

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways



4         Kegg Pathways  (Kegg details for ZNRD1):
    Purine metabolism
Pyrimidine metabolism
Metabolic pathways
RNA polymerase


ZNRD1 for pathways           About GeneDecksing

Interactions:

    SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ZNRD1

STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

5/12 Interacting proteins for ZNRD1 (Q9P1U02, 3 ENSP000003311114) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
InteractantInteraction Details
GeneCardExternal ID(s)
NONOQ152333, ENSP000002760794I2D: score=4 STRING: ENSP00000276079
CICQ96RK03, ENSP000001607404I2D: score=2 STRING: ENSP00000160740
GFI1BQ5VTD93, ENSP000003447824I2D: score=2 STRING: ENSP00000344782
SACSQ9NZJ43, ENSP000003717294I2D: score=2 STRING: ENSP00000371729
ATXN2Q997003, ENSP000003668434I2D: score=2 STRING: ENSP00000366843
About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006139nucleobase-containing compound metabolic process TAS10662553
GO:0006351transcription, DNA-dependent IEA--

ZNRD1 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

ZNRD1 for compounds           About GeneDecksing

Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ZNRD1 (RPA12)

6 HMDB Compounds for ZNRD1    About this table
CompoundSynonyms CAS #PubMed Ids
Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
Cytidine triphosphatecytidine 5'-(tetrahydrogen triphosphate) (see all 15)65-47-4--
Guanosine triphosphate5'-GTP (see all 10)86-01-1--
Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--
Uridine triphosphate5'-UTP (see all 7)63-39-8--

3 Novoseek inferred chemical compound relationships for ZNRD1 gene    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
zinc 53.6 6 10662553 (2), 16373708 (2), 14726695 (1), 15358150 (1)
adriamycin 51.7 6 14726695 (2), 16373708 (1)
vincristine 49.3 4 14726695 (2), 16373708 (1)

Search CenterWatch for drugs/clinical trials and news about ZNRD1 / RPA12

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ZNRD1 gene (4 alternative transcripts): 
NM_001278785.1  NM_001278786.1  NM_014596.5  NM_170783.3  

Unigene Cluster for ZNRD1:

Zinc ribbon domain containing 1
Hs.57813  [show with all ESTs]
Unigene Representative Sequence: BM557164
6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000471008 ENST00000332435(uc003npa.3) ENST00000376782 ENST00000359374(uc003noz.3)
ENST00000376785 ENST00000463141
miRNA
Products:
     
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ZNRD1
Search QIAGEN for miScript miRNA Assays for microRNAs that regulate ZNRD1
SwitchGear 3'UTR luciferase reporter plasmidZNRD1 3' UTR sequence
Inhib. RNA
Products:
     
Browse for Gene Knock-down Tools from EMD Millipore
OriGene RNAi products in human, mouse, rat for ZNRD1
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZNRD1
Clone
Products:
     
OriGene clones in human, mouse for ZNRD1 (see all 13)
OriGene ORF clones in mouse, rat for ZNRD1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector (see all 2): ZNRD1 (NM_014596)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for ZNRD1
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNRD1
Sirion Biotech Customized lentivirus for stable overexpression of ZNRD1 
                     Customized lentivirus expression plasmids for stable overexpression of ZNRD1 
Primer
Products:
    
OriGene qPCR primer pairs and template standards for ZNRD1
OriGene qSTAR qPCR primer pairs in human, mouse for ZNRD1
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ZNRD1
  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNRD1
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNRD1

Additional mRNA sequence: 

AF024617.1 AF230337.1 AF238320.1 AF238321.1 AK225874.1 BC010898.1 BC050608.1 CR457109.1 
L19693.1 

11 DOTS entries:

DT.100751277  DT.454677  DT.92004981  DT.121346042  DT.121346302  DT.75126766  DT.92424132  DT.95272103 
DT.121346150  DT.92424131  DT.92424130 

11 AceView cDNA sequences:

NM_014596 AF230337 AF238321 AF238320 NM_170783 AF024616 BC010898 BC050608 
CR457109 BC051741 AF024617 

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for ZNRD1 (see all 6)    About this scheme

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c
SP1:                                -                                       
SP2:                                                                        
SP3:                          -     -                                       
SP4:                                                                        
SP5:                                -           -                           


ECgene alternative splicing isoforms for ZNRD1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ZNRD1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TGGGGATTAC
ZNRD1 Expression
About this image


See ZNRD1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZNRD1

SOURCE GeneReport for Unigene cluster: Hs.57813
    SABiosciences Custom PCR Arrays for ZNRD1
Primer
Products:
OriGene qPCR primer pairs and template standards for ZNRD1
OriGene qSTAR qPCR primer pairs in human, mouse for ZNRD1
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ZNRD1
QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNRD1
QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNRD1
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNRD1

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals and fungi.

Orthologs for ZNRD1 gene from 7/16 species (see all 16)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Znrd11 , 5 zinc ribbon domain containing, 11, 5 80.76(n)1
82.11(a)1
  17 (19.16 cM)5
661361  NM_023162.41  NP_075651.11 
 369543585 
lizard
(Anolis carolinensis)
Reptilia ZNRD16
DNA-directed RNA polymerase subunit
58(a)
1 ↔ 1
2(192731455-192735520)
African clawed frog
(Xenopus laevis)
Amphibia Xl.336132 Xenopus laevis transcribed sequence with weak similarity more 75.93(n)    BJ613134.1 
zebrafish
(Danio rerio)
Actinopterygii BI867463.12   -- 77.55(n)    BI867463.1 
fruit fly
(Drosophila melanogaster)
Insecta RpI121 CG13418-PA 50(n)
43.86(a)
  42563  NM_079715.2  NP_524439.1 
worm
(Caenorhabditis elegans)
Secernentea rpoa-126
Protein C15H11.8
37(a)
1 ↔ 1
V(14422720-14423361)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPA12(YJR063W)4 RNA polymerase I subunit A12.2; contains two zinc binding more   --   10(555195-555572) 853526  NP_012597.1 


ENSEMBL Gene Tree for ZNRD1 (if available)
TreeFam Gene Tree for ZNRD1 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/49 SNPs in ZNRD1 are shown (see all 49)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 6 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
VAR_0522874
----see VAR_0522872 Q H mis40--------
rs1817847581,2
C--30031019(+) GACCTC/TGAATT 2 -- int10--------
rs92612761,2
C,F,H--30031059(+) TCCTCC/TATTTC 2 -- int19Minor allele frequency- T:0.06NS EA CSA WA NA 778
rs92612771,2
C,F,H--30031091(+) TCAATT/CGCTGT 2 -- int118Minor allele frequency- C:0.19NS EA WA CSA NA 2342
rs11507391,2
C,F,A,H--30031345(-) attatA/Gagaca 2 -- int126Minor allele frequency- G:0.47NS EA NA WA CSA 2940
rs92612781,2
C,F,A,H--30031362(+) atctgC/Tggatt 2 -- int111Minor allele frequency- T:0.19NS EA WA CSA NA 784
rs562706811,2
C,F--30031456(+) AATTCG/AAGTTT 2 -- int12Minor allele frequency- A:0.08NA EA 240
rs1474639691,2
C--30031506(+) CGAGTA/GCTGTA 2 -- int10--------
rs790433701,2
C--30031556(+) ACTATC/TAAGCT 2 -- int10--------
rs744668001,2
C--30031557(+) CTATCA/GAGCTG 2 -- int10--------

HapMap Linkage Disequilibrium report for ZNRD1 (30026676 - 30032686 bp)

Structural Variations
     Database of Genomic Variants (DGV) 1 variation for ZNRD1:    About this table     
Variant IDTypeSubtypePubMed ID
esv2731777CNV Deletion23290073

SABiosciences Cancer Mutation PCR Assays
SeqTarget long-range PCR primers for resequencing ZNRD1
DNA2.0 Custom Variant and Variant Library Synthesis for ZNRD1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
OMIM gene information: 607525    OMIM disorders: --

12 diseases for ZNRD1:    About MalaCards
stomach cancer    gastric adenocarcinoma    gestational diabetes    esophageal cancer
gastric cancer    esophageal squamous cell carcinoma    esophagitis    systemic lupus erythematosus
lupus erythematosus    squamous cell carcinoma    adenocarcinoma    leukemia


ZNRD1 for disorders           About GeneDecksing

1 Novoseek inferred disease relationship for ZNRD1 gene    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
gastric cancer 59.6 17 15358150 (5), 14726695 (4), 16609701 (3), 15662122 (2) (see all 5)

Genetic Association Database (GAD): ZNRD1
Human Genome Epidemiology (HuGE) Navigator: ZNRD1 (10 documents)

Export disorders for ZNRD1 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for ZNRD1 gene, integrated from 9 sources (see all 37):
(articles sorted by number of sources associating them with ZNRD1)
    Utopia: connect your pdf to the dynamic
world of online information

  1. A new zinc ribbon gene (ZNRD1) is cloned from the human MHC class I region. (PubMed id 10662553)1, 2, 3, 9 Fan W.... Lennon G. (2000)
  2. Examination of genetic polymorphisms in newborns for signatures of sex-specific prenatal selection. (PubMed id 20587610)1, 4 Ucisik-Akkaya E....Tevfik Dorak M. (2010)
  3. ZNRD1 (zinc ribbon domain-containing 1) is a host cel lular factor that influences HIV-1 replication and disease progression. (PubMed id 20192730)1, 4 Ballana E....EstAc J.A. (2010)
  4. Common genetic variation and the control of HIV-1 in humans. (PubMed id 20041166)1, 4 Fellay J....Goldstein D.B. (2009)
  5. The HLA-B/-C haplotype block contains major determina nts for host control of HIV. (PubMed id 19693088)1, 4 Trachtenberg E....Wolinsky S. (2009)
  6. Genomewide association study of an AIDS-nonprogression cohort emphasizes the role played by HLA genes (ANRS Genomewide Association Study 02). (PubMed id 19115949)1, 4 Limou S....Zagury J.F. (2009)
  7. Association of HLA-C and HCP5 gene regions with the clinical course of HIV-1 infection. (PubMed id 19050382)1, 4 van Manen D....Schuitemaker H. (2009)
  8. High-density SNP screening of the major histocompatib ility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PubMed id 19851445)1, 4 Barcellos L.F....Criswell L.A. (2009)
  9. HIV-1 disease-influencing effects associated with ZNRD1, HCP5 and HLA-C alleles are attributable mainly to either HLA-A10 or HLA-B*57 alleles. (PubMed id 18982067)1, 4 Catano G....Ahuja S.K. (2008)
  10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Disorders
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 30834 HGNC: 13182 AceView: ZNRD1 Ensembl:ENSG00000066379 euGenes: HUgn30834
ECgene: ZNRD1 Kegg: 30834 H-InvDB: ZNRD1

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for ZNRD1 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for ZNRD1 gene:
Search GeneIP for patents involving ZNRD1

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

 
 EMD Millipore Custom Antibody & Bulk Services
 EMD Millipore Preclinical / Clinical Development Services
 EMD Millipore Immunoassay Services
 EMD Millipore Target Screening & Profiling Services

  
 Browse Antibodies   Browse Cell Culture Products  
 Browse ELISAs   Browse Flow Cytometry Kits  
 Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
 Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
 Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
 Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
 Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
 Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
 Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
 Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
 OriGene Antibodies for ZNRD1   OriGene RNAi products in human, mouse, rat for ZNRD1  
 OriGene qPCR primer pairs and template standards for ZNRD1   OriGene Protein Over-expression Lysate for ZNRD1  
 OriGene MassSpec something-or-other for ZNRD1   OriGene clones in human, mouse for ZNRD1  
 OriGene qSTAR qPCR primer pairs in human, mouse for ZNRD1   OriGene Purified Protein for ZNRD1  
 OriGene ORF clones in mouse, rat for ZNRD1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
 OriGene Custom Antibody Services for ZNRD1   OriGene Custom Protein Services for ZNRD1  

 
 
 QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ZNRD1
 QIAGEN SeqTarget long-range PCR primers for resequencing ZNRD1
 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNRD1
 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZNRD1
 QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNRD1
 QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNRD1
 GenScript Custom Purified and Recombinant Proteins Services for ZNRD1 GenScript cDNA clones with any tag delivered in your preferred vector for ZNRD1
 GenScript Custom Assay Services for ZNRD1 GenScript Custom Superior Antibodies Services for ZNRD1
 GenScript Custom overexpressing Cell Line Services for ZNRD1 CloneReady with Over 120,000 Genes
 Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
 Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
 Custom Peptide Services
 Search for Antibodies & Assays

 Regulatory tfbs in ZNRD1 promoter
 Search Chromatin IP Primers for ZNRD1
 RT2 qPCR Primer Assay in human, mouse, rat ZNRD1
 GNC Network for ZNRD1
 SABiosciences Custom PCR Arrays for ZNRD1
 Search Tocris compounds for ZNRD1 (RPA12)
 Browse Sino Biological Proteins and Antibodies
 Browse Sino Biological Cell Lysates
 Browse Sino Biological cDNA Clones
 4000+ Proteins
 Search Sino Biological for antibodies, proteins & pathways
 Protein Production Services
 Transfection Reagents
 Protein A/G/L resins
 Isotyping reagents
 Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
 Novus Tissue Slides
 ZNRD1 antibodies
 ZNRD1 proteins
 ZNRD1 lysates
 Antibodies for ZNRD1
 See all of Abcam's Antibodies, Kits and Proteins for ZNRD1
 Custom Antibody / Protein Production Service
 Bulk Purchasing
 Advantages of Rabbit Monoclonal antibodies
 Abcam protocols and scientific support
 Browse ProSpec Recombinant Proteins




 Proteins for ZNRD1
 Antibodies for ZNRD1
 ELISAs for ZNRD1
 CLIAs for ZNRD1
 Search LifeMap BioReagents cell lines for ZNRD1
 Gene Synthesis
 Protein Engineering
 Variant Library Synthesis
 Codon Optimization
 Protein Production and Purification
 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNRD1
 SwitchGear 3'UTR luciferase reporter plasmids for ZNRD1
 SwitchGear Promoter luciferase reporter plasmids for ZNRD1
 Search ThermoFisher Antibodies for ZNRD1
 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNRD1
 inGenious Targeting Laboratory - Custom generated mouse model solutions for ZNRD1
 inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ZNRD1
Customized:
 lentivirus for stable overexpression of ZNRD1
 lentivirus expression plasmids for stable overexpression of ZNRD1
 adenovirus for overexpression of ZNRD1
 LSBio Antibodies in human, mouse, rat for ZNRD1
Customized transgenic rodents for:
 Humanization
 Biomarker expression
 Off-target effect monitoring
 Translational medicine
 Tissue-specific gene expresssion
 Time-controlled gene expresssion
       
GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

View Random Gene

Category
(GIFtS: 73)
transforming growth factor, beta 1
GIFtS Group
The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes      Disease genes      ZNRD1 gene at Home site.
hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4