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Aliases for ZNHIT6 Gene

Aliases for ZNHIT6 Gene

  • Zinc Finger, HIT-Type Containing 6 2 3
  • Serologically Defined Breast Cancer Antigen NY-BR-75 3 4
  • Zinc Finger HIT Domain-Containing Protein 6 3 4
  • Zinc Finger, HIT Type 6 2 3
  • C1orf181 3 4
  • BCD1 3 4
  • Box C/D SnoRNA Essential 1 Homolog (S. Cerevisiae) 2
  • Chromosome 1 Open Reading Frame 181 2
  • Box C/D SnoRNA Essential 1 Homolog 3
  • Box C/D SnoRNA Protein 1 3
  • NY-BR-75 3

External Ids for ZNHIT6 Gene

Previous HGNC Symbols for ZNHIT6 Gene

  • C1orf181

Previous GeneCards Identifiers for ZNHIT6 Gene

  • GC01M085891
  • GC01M086118
  • GC01M084225

Summaries for ZNHIT6 Gene

GeneCards Summary for ZNHIT6 Gene

ZNHIT6 (Zinc Finger, HIT-Type Containing 6) is a Protein Coding gene. Diseases associated with ZNHIT6 include breast cancer. GO annotations related to this gene include identical protein binding.

UniProtKB/Swiss-Prot for ZNHIT6 Gene

  • Required for box C/D snoRNAs accumulation involved in snoRNA processing, snoRNA transport to the nucleolus and ribosome biogenesis.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNHIT6 Gene

Genomics for ZNHIT6 Gene

Regulatory Elements for ZNHIT6 Gene

Genomic Location for ZNHIT6 Gene

85,649,423 bp from pter
85,708,433 bp from pter
59,011 bases
Minus strand

Genomic View for ZNHIT6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNHIT6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNHIT6 Gene

Proteins for ZNHIT6 Gene

  • Protein details for ZNHIT6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Box C/D snoRNA protein 1
    Protein Accession:
    Secondary Accessions:
    • B2RBA1
    • B4DP13
    • D3DT20
    • Q9H278
    • Q9H3X3
    • Q9NWN0

    Protein attributes for ZNHIT6 Gene

    470 amino acids
    Molecular mass:
    53918 Da
    Quaternary structure:
    • Interacts with FBL, NHP2L1, NOP58, NUFIP1, RUVBL1, RUVBL2 and TAF9.
    • Sequence=AAG48263.1; Type=Frameshift; Positions=365, 412, 416, 419, 432; Evidence={ECO:0000305}; Sequence=BAA91349.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNHIT6 Gene


neXtProt entry for ZNHIT6 Gene

Proteomics data for ZNHIT6 Gene at MOPED

Post-translational modifications for ZNHIT6 Gene

  • Ubiquitination at Lys229, Lys362, and Lys424
  • Modification sites at PhosphoSitePlus

Other Protein References for ZNHIT6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNHIT6 Gene

Domains for ZNHIT6 Gene

Gene Families for ZNHIT6 Gene

  • ZNHIT :Zinc fingers, HIT-type

Protein Domains for ZNHIT6 Gene


Suggested Antigen Peptide Sequences for ZNHIT6 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q9NWK9
  • Belongs to the BCD1 family.
  • Contains 1 HIT-type zinc finger.
genes like me logo Genes that share domains with ZNHIT6: view

Function for ZNHIT6 Gene

Molecular function for ZNHIT6 Gene

UniProtKB/Swiss-Prot Function: Required for box C/D snoRNAs accumulation involved in snoRNA processing, snoRNA transport to the nucleolus and ribosome biogenesis.

Gene Ontology (GO) - Molecular Function for ZNHIT6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17636026
GO:0019899 enzyme binding IPI 23382074
GO:0042802 identical protein binding IPI 17636026
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNHIT6: view

Animal Model Products

CRISPR Products

miRNA for ZNHIT6 Gene

miRTarBase miRNAs that target ZNHIT6

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNHIT6

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for ZNHIT6 Gene

Localization for ZNHIT6 Gene

Subcellular locations from

Jensen Localization Image for ZNHIT6 Gene COMPARTMENTS Subcellular localization image for ZNHIT6 gene
Compartment Confidence
cytosol 2
nucleus 2

Gene Ontology (GO) - Cellular Components for ZNHIT6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 19056867
GO:0070761 pre-snoRNP complex IDA 17636026
genes like me logo Genes that share ontologies with ZNHIT6: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ZNHIT6 Gene

Pathways for ZNHIT6 Gene

SuperPathways for ZNHIT6 Gene

No Data Available

Interacting Proteins for ZNHIT6 Gene

Gene Ontology (GO) - Biological Process for ZNHIT6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000492 box C/D snoRNP assembly IMP 17636026
GO:0042254 ribosome biogenesis IEA --
genes like me logo Genes that share ontologies with ZNHIT6: view

No data available for Pathways by source for ZNHIT6 Gene

Transcripts for ZNHIT6 Gene

Unigene Clusters for ZNHIT6 Gene

Zinc finger, HIT-type containing 6:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNHIT6

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNHIT6 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11

Relevant External Links for ZNHIT6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNHIT6 Gene

mRNA expression in normal human tissues for ZNHIT6 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZNHIT6 Gene

SOURCE GeneReport for Unigene cluster for ZNHIT6 Gene Hs.5111

genes like me logo Genes that share expressions with ZNHIT6: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNHIT6 Gene

Orthologs for ZNHIT6 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ZNHIT6 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNHIT6 35
  • 99.65 (n)
  • 99.57 (a)
  • 100 (a)
(Bos Taurus)
Mammalia ZNHIT6 35
  • 86.02 (n)
  • 79.35 (a)
  • 79 (a)
(Canis familiaris)
Mammalia ZNHIT6 35
  • 84.63 (n)
  • 78.23 (a)
  • 78 (a)
(Mus musculus)
Mammalia Znhit6 35
  • 79.21 (n)
  • 74.61 (a)
Znhit6 16
Znhit6 36
  • 73 (a)
(Monodelphis domestica)
Mammalia ZNHIT6 36
  • 48 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 54 (a)
-- 36
  • 68 (a)
(Rattus norvegicus)
Mammalia Znhit6 35
  • 77.95 (n)
  • 72.38 (a)
(Gallus gallus)
Aves ZNHIT6 35
  • 68.87 (n)
  • 65.37 (a)
  • 60 (a)
(Anolis carolinensis)
Reptilia ZNHIT6 36
  • 60 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.25224 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.6177 35
znhit6 35
  • 64.8 (n)
  • 59.6 (a)
(Danio rerio)
Actinopterygii ZNHIT6 36
  • 33 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004678 35
  • 50 (n)
  • 38.6 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG1463 35
  • 44.35 (n)
  • 32.17 (a)
CG1463 36
  • 23 (a)
(Caenorhabditis elegans)
Secernentea zhit-3 36
  • 16 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes BCD1 36
  • 18 (a)
BCD1 38
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 27 (a)
CSA.448 36
  • 31 (a)
Species with no ortholog for ZNHIT6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZNHIT6 Gene

Gene Tree for ZNHIT6 (if available)
Gene Tree for ZNHIT6 (if available)

Paralogs for ZNHIT6 Gene

No data available for Paralogs for ZNHIT6 Gene

Variants for ZNHIT6 Gene

Sequence variations from dbSNP and Humsavar for ZNHIT6 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs10791 -- 85,652,904(-) TTTGA(A/T)CTCAT utr-variant-3-prime
rs821377 -- 85,674,234(-) AAGCT(C/T)ATCTT intron-variant
rs821378 -- 85,673,406(-) ACATG(A/G)CTTAT intron-variant
rs821379 -- 85,673,276(-) GCTTT(C/T)TAAAT intron-variant
rs821380 -- 85,672,063(-) TGAAA(C/T)TGTAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNHIT6 Gene

Variant ID Type Subtype PubMed ID
nsv871471 CNV Gain 21882294
nsv509369 CNV Insertion 20534489
nsv506942 CNV Insertion 20534489

Relevant External Links for ZNHIT6 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNHIT6 Gene

Disorders for ZNHIT6 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for ZNHIT6 Gene including...

Search for ZNHIT6 Gene in MalaCards »

Relevant External Links for ZNHIT6

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with ZNHIT6: view

No data available for UniProtKB/Swiss-Prot for ZNHIT6 Gene

Publications for ZNHIT6 Gene

  1. Humoral immunity to human breast cancer: antigen definition and quantitative analysis of mRNA expression. (PMID: 12747765) Scanlan M.J. … Old L.J. (Cancer Immun. 2001) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. A dynamic scaffold of pre-snoRNP factors facilitates human box C/D snoRNP assembly. (PMID: 17636026) McKeegan K.S. … Watkins N.J. (Mol. Cell. Biol. 2007) 3 4
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48

Products for ZNHIT6 Gene

Sources for ZNHIT6 Gene

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