ZNHIT6 Gene
protein-coding GIFtS: 46
GCID: GC01M086118
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zinc finger, HIT-type containing 6(Previous names: chromosome 1 open reading frame 181, zinc finger, HIT type...)
(Previous symbol: C1orf181)
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Aliases
for ZNHIT6 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger, HIT-Type Containing 61 2 | | Zinc Finger HIT Domain-Containing Protein 62 3 | | BCD11 2 3 | | FLJ207291 | | C1orf1811 2 3 | | Chromosome 1 Open Reading Frame 1811 | | NY-BR-751 2 | | Box C/D SnoRNA Essential 1 Homolog2 | | Zinc Finger, HIT Type 61 2 | | Box C/D SnoRNA Protein 12 | | Serologically Defined Breast Cancer Antigen NY-BR-752 3 | | |
Export aliases for ZNHIT6 gene to outside databasesPrevious GC identifers: GC01M085891 GC01M084225 |
Summaries
for ZNHIT6 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: BCD1_HUMAN, Q9NWK9Function: Required for box C/D snoRNAs accumulation involved in snoRNA processing, snoRNA transport to the nucleolusand ribosome biogenesis
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Genomic Views
for ZNHIT6 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_032977.9
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZNHIT6 gene promoter:
AhR Tal-1 E4BP4 E47 Arnt AREB6 HEN1 HSF2 FOXO1a FOXO1
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZNHIT6
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNHIT6 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p22.3 Ensembl cytogenetic band: 1p22.3 HGNC cytogenetic band: 1p22.3ZNHIT6 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M086118: view genomic region
(about GC identifiers)
Start:
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86,115,106 bp from pter |
End:
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86,174,116 bp from pter |
Size:
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59,011 bases |
Orientation:
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minus strand |
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Proteins
for ZNHIT6 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: BCD1_HUMAN, Q9NWK9 (See
protein sequence)Recommended Name: Box C/D snoRNA protein 1 Size: 470 amino acids; 53918 Da
Subunit: Interacts with FBL, NHP2L1, NOP58, NUFIP1, RUVBL1, RUVBL2 and TAF9
Sequence caution: Sequence=AAG48263.1; Type=Frameshift; Positions=365, 412, 416, 419, 432; Sequence=BAA91349.1;Type=Erroneous initiation;
Secondary accessions: B2RBA1 B4DP13 D3DT20 Q9H278 Q9H3X3 Q9NWN0Alternative splicing: 2 isoforms: Q9NWK9-1 Q9NWK9-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for ZNHIT6: NX_Q9NWK9
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9NWK9
ZNHIT6 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001164141.1 NP_060423.3
ENSEMBL proteins: ENSP00000359606 ENSP00000414344
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table
ZNHIT6 for ontologies About GeneDecksing
ZNHIT6 Antibody Products:
Assay Products for ZNHIT6: |
Protein
Domains /
Families
for ZNHIT6 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZNHIT6 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9NWK9ProtoNet protein and cluster: Q9NWK9 1 Blocks protein family: IPB007529 HIT Zn-finger
UniProtKB/Swiss-Prot: BCD1_HUMAN, Q9NWK9Similarity: Belongs to the BCD1 familySimilarity: Contains 1 HIT-type zinc finger |
Function
for ZNHIT6 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: BCD1_HUMAN, Q9NWK9Function: Required for box C/D snoRNAs accumulation involved in snoRNA processing, snoRNA transport to the nucleolusand ribosome biogenesis
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNHIT6 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNHIT6 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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Synthesis Service for ZNHIT6 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNHIT6 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNHIT6 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
ZNHIT6 for ontologies About GeneDecksing
|
Pathways & Interactions
for ZNHIT6 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNHIT6
STRING Interaction
Network Preview (showing 5 interactants - click image to see 7)
5/39 Interacting proteins for ZNHIT6 (Q9NWK92, 3 ENSP000003596064) via UniProtKB, MINT, STRING, and/or I2D (see all 39)About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table
ZNHIT6 for ontologies About GeneDecksing
|
Drugs & Compounds
for ZNHIT6 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZNHIT6
Search CenterWatch for drugs/clinical trials and news about ZNHIT6 / BCD1
|
Transcripts
for ZNHIT6 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZNHIT6 gene (2 alternative transcripts): NM_001170670.1 NM_017953.3 Unigene Cluster for ZNHIT6: Zinc finger, HIT-type containing 6 Hs.5111 [show with all ESTs]Unigene Representative Sequence: NM_0179532 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000370574 ENST00000431532(uc010osc.2 uc001dlh.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNHIT6 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNHIT6 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): ZNHIT6 (NM_017953) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNHIT6 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNHIT6 |
Additional cDNA sequence: AF308296.1 AK000736.1 AK000767.1 AK022664.1 AK298149.1 AK314566.1 AL442074.1 BC026236.1 BC110898.1 5 DOTS entries: DT.445746 DT.206030 DT.121346731 DT.121346743 DT.91846853 24/108 AceView cDNA sequences (see all 108): CN479528 AA707350 BP357858 BQ216260 CR623162 BM999375 AK000767 AL602717 CA450269 CK822464 BU169764 AA190578 BM128077 BU616955 BM504972 BM504646 BQ220369 AI080350 AL556536 AA743633 BQ019692 BC026236 AK000736 AI632307
GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for ZNHIT6 About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 |
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| SP1: | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for ZNHIT6
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Expression
for ZNHIT6 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZNHIT6 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TACTGAAAAA
About this image
See ZNHIT6 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZNHIT6
SOURCE GeneReport for Unigene cluster: Hs.5111
SABiosciences Custom PCR Arrays for ZNHIT6
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNHIT6
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ZNHIT6 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNHIT6 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNHIT6 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNHIT6 |
Orthologs
for ZNHIT6 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for ZNHIT6 gene from 8/28 species (see all 28) About this table
ENSEMBL Gene Tree for ZNHIT6 (if available)
TreeFam Gene Tree for ZNHIT6 (if available) |
Paralogs
for ZNHIT6 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for ZNHIT6 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZNHIT6 (86115106 - 86174116 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ZNHIT6: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNHIT6 |
|
Disorders
/ Diseases
for ZNHIT6 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ZNHIT6 for disorders About GeneDecksing
2  diseases for ZNHIT6: About MalaCardsbreast cancer gout
Human Genome Epidemiology (HuGE) Navigator: ZNHIT6 (1 document)
Export disorders for ZNHIT6 gene to outside databases
|
Publications
for ZNHIT6 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZNHIT6 gene, integrated from 9 sources (see all 21):
(articles sorted by number of sources associating them with ZNHIT6) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Humoral immunity to human breast cancer: antigen definition and quantitative analysis of mRNA expression. (PubMed id 12747765)1, 2, 3 Scanlan M.J.... Old L.J. (2001)
- A dynamic scaffold of pre-snoRNP factors facilitates human box C/D snoRNP assembly. (PubMed id 17636026)1, 2 McKeegan K.S....Watkins N.J. (2007)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Comparative proteomic analysis identifies a role for S UMO in protein quality control. (PubMed id 21693764)1 Tatham M.H....Hay R.T. (2011)
- Global identification of modular cullin-RING ligase su bstrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (2011)
- Purification and identification of endogenous polySUMO conjugates. (PubMed id 21252943)1 Bruderer R....Hay R.T. (2011)
|
External Searches for ZNHIT6 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing ZNHIT6 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZNHIT6 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZNHIT6 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZNHIT6 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for ZNHIT6 gene:
Search GeneIP for patents involving ZNHIT6
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZNHIT6 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ZNHIT6 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZNHIT6 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNHIT6 | | | OriGene Protein Over-expression Lysate for ZNHIT6 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ZNHIT6 | | OriGene 3'-UTR Clone for ZNHIT6 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNHIT6 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNHIT6 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ZNHIT6 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNHIT6 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNHIT6 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZNHIT6 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNHIT6 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNHIT6 |
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| | | | Search Tocris compounds for ZNHIT6 |
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 | | | ZNHIT6 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNHIT6 |
|  |  |  | | | | Search ThermoFisher Antibodies for ZNHIT6 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNHIT6 |
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