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Aliases for ZNHIT6 Gene

Aliases for ZNHIT6 Gene

  • Zinc Finger, HIT-Type Containing 6 2 3
  • Serologically Defined Breast Cancer Antigen NY-BR-75 3 4
  • Zinc Finger HIT Domain-Containing Protein 6 3 4
  • Zinc Finger, HIT Type 6 2 3
  • C1orf181 3 4
  • BCD1 3 4
  • Box C/D SnoRNA Essential 1 Homolog (S. Cerevisiae) 2
  • Chromosome 1 Open Reading Frame 181 2
  • Box C/D SnoRNA Essential 1 Homolog 3
  • Box C/D SnoRNA Protein 1 3
  • NY-BR-75 3

External Ids for ZNHIT6 Gene

Previous Symbols for ZNHIT6 Gene

  • C1orf181

Summaries for ZNHIT6 Gene

GeneCards Summary for ZNHIT6 Gene

ZNHIT6 (Zinc Finger, HIT-Type Containing 6) is a Protein Coding gene. Diseases associated with ZNHIT6 include breast cancer. GO annotations related to this gene include identical protein binding.

UniProtKB/Swiss-Prot for ZNHIT6 Gene

  • Required for box C/D snoRNAs accumulation involved in snoRNA processing, snoRNA transport to the nucleolus and ribosome biogenesis.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNHIT6 Gene

Genomics for ZNHIT6 Gene

Genomic Location for ZNHIT6 Gene

Start:
85,649,423 bp from pter
End:
85,708,433 bp from pter
Size:
59,011 bases
Orientation:
Minus strand

Genomic View for ZNHIT6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNHIT6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNHIT6 Gene

Regulatory Elements for ZNHIT6 Gene

Proteins for ZNHIT6 Gene

  • Protein details for ZNHIT6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NWK9-BCD1_HUMAN
    Recommended name:
    Box C/D snoRNA protein 1
    Protein Accession:
    Q9NWK9
    Secondary Accessions:
    • B2RBA1
    • B4DP13
    • D3DT20
    • Q9H278
    • Q9H3X3
    • Q9NWN0

    Protein attributes for ZNHIT6 Gene

    Size:
    470 amino acids
    Molecular mass:
    53918 Da
    Quaternary structure:
    • Interacts with FBL, NHP2L1, NOP58, NUFIP1, RUVBL1, RUVBL2 and TAF9.
    SequenceCaution:
    • Sequence=AAG48263.1; Type=Frameshift; Positions=365, 412, 416, 419, 432; Evidence={ECO:0000305}; Sequence=BAA91349.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNHIT6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNHIT6 Gene

Proteomics data for ZNHIT6 Gene at MOPED

Post-translational modifications for ZNHIT6 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys229, Lys362, and Lys424

Other Protein References for ZNHIT6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNHIT6 Gene

Domains for ZNHIT6 Gene

Gene Families for ZNHIT6 Gene

HGNC:
  • ZNHIT :Zinc fingers, HIT-type

Protein Domains for ZNHIT6 Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

BCD1_HUMAN
Family:
  • Belongs to the BCD1 family.:
    • Q9NWK9
Similarity:
  • Contains 1 HIT-type zinc finger.:
    • Q9NWK9
genes like me logo Genes that share domains with ZNHIT6: view

Function for ZNHIT6 Gene

Molecular function for ZNHIT6 Gene

UniProtKB/Swiss-Prot Function: Required for box C/D snoRNAs accumulation involved in snoRNA processing, snoRNA transport to the nucleolus and ribosome biogenesis.

Gene Ontology (GO) - Molecular Function for ZNHIT6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17636026
GO:0019899 enzyme binding IPI 23382074
GO:0042802 identical protein binding IPI 17636026
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNHIT6: view

miRNA for ZNHIT6 Gene

miRTarBase miRNAs that target ZNHIT6

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for ZNHIT6 Gene

Localization for ZNHIT6 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNHIT6 Gene COMPARTMENTS Subcellular localization image for ZNHIT6 gene
Compartment Confidence
cytosol 2
nucleus 2

Gene Ontology (GO) - Cellular Components for ZNHIT6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 19056867
GO:0070761 pre-snoRNP complex IDA 17636026
genes like me logo Genes that share ontologies with ZNHIT6: view

Pathways for ZNHIT6 Gene

SuperPathways for ZNHIT6 Gene

No Data Available

Interacting Proteins for ZNHIT6 Gene

Gene Ontology (GO) - Biological Process for ZNHIT6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000492 box C/D snoRNP assembly IMP 17636026
GO:0042254 ribosome biogenesis IEA --
genes like me logo Genes that share ontologies with ZNHIT6: view

No data available for Pathways by source for ZNHIT6 Gene

Transcripts for ZNHIT6 Gene

Unigene Clusters for ZNHIT6 Gene

Zinc finger, HIT-type containing 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNHIT6 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
SP1:
SP2:

Relevant External Links for ZNHIT6 Gene

GeneLoc Exon Structure for
ZNHIT6
ECgene alternative splicing isoforms for
ZNHIT6

Expression for ZNHIT6 Gene

mRNA expression in normal human tissues for ZNHIT6 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZNHIT6 Gene

SOURCE GeneReport for Unigene cluster for ZNHIT6 Gene Hs.5111

genes like me logo Genes that share expressions with ZNHIT6: view

Orthologs for ZNHIT6 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ZNHIT6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNHIT6 36
  • 99.65 (n)
  • 99.57 (a)
ZNHIT6 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZNHIT6 36
  • 86.02 (n)
  • 79.35 (a)
ZNHIT6 37
  • 79 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZNHIT6 36
  • 84.63 (n)
  • 78.23 (a)
ZNHIT6 37
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Znhit6 36
  • 79.21 (n)
  • 74.61 (a)
Znhit6 16
Znhit6 37
  • 73 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZNHIT6 37
  • 48 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 54 (a)
OneToMany
-- 37
  • 68 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Znhit6 36
  • 77.95 (n)
  • 72.38 (a)
chicken
(Gallus gallus)
Aves ZNHIT6 36
  • 68.87 (n)
  • 65.37 (a)
ZNHIT6 37
  • 60 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZNHIT6 37
  • 60 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.25224 36
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.6177 36
znhit6 36
  • 64.8 (n)
  • 59.6 (a)
zebrafish
(Danio rerio)
Actinopterygii ZNHIT6 37
  • 33 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004678 36
  • 50 (n)
  • 38.6 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG1463 36
  • 44.35 (n)
  • 32.17 (a)
CG1463 37
  • 23 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea zhit-3 37
  • 16 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes BCD1 37
  • 18 (a)
OneToOne
BCD1 39
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 27 (a)
OneToMany
CSA.448 37
  • 31 (a)
OneToMany
Species with no ortholog for ZNHIT6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZNHIT6 Gene

ENSEMBL:
Gene Tree for ZNHIT6 (if available)
TreeFam:
Gene Tree for ZNHIT6 (if available)

Paralogs for ZNHIT6 Gene

No data available for Paralogs for ZNHIT6 Gene

Variants for ZNHIT6 Gene

Sequence variations from dbSNP and Humsavar for ZNHIT6 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs10791 -- 85,652,904(-) TTTGA(A/T)CTCAT utr-variant-3-prime
rs821377 -- 85,674,234(-) AAGCT(C/T)ATCTT intron-variant
rs821378 -- 85,673,406(-) ACATG(A/G)CTTAT intron-variant
rs821379 -- 85,673,276(-) GCTTT(C/T)TAAAT intron-variant
rs821380 -- 85,672,063(-) TGAAA(C/T)TGTAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNHIT6 Gene

Variant ID Type Subtype PubMed ID
nsv871471 CNV Gain 21882294
nsv509369 CNV Insertion 20534489
nsv506942 CNV Insertion 20534489

Relevant External Links for ZNHIT6 Gene

HapMap Linkage Disequilibrium report
ZNHIT6

Disorders for ZNHIT6 Gene

(1) MalaCards Diseases for ZNHIT6 Gene

Search for ZNHIT6 Gene in MalaCards »

Relevant External Links for ZNHIT6

Genetic Association Database (GAD)
ZNHIT6
Human Genome Epidemiology (HuGE) Navigator
ZNHIT6
genes like me logo Genes that share disorders with ZNHIT6: view

No data available for UniProtKB/Swiss-Prot for ZNHIT6 Gene

Publications for ZNHIT6 Gene

  1. Humoral immunity to human breast cancer: antigen definition and quantitative analysis of mRNA expression. (PMID: 12747765) Scanlan M.J. … Old L.J. (Cancer Immun. 2001) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. A dynamic scaffold of pre-snoRNP factors facilitates human box C/D snoRNP assembly. (PMID: 17636026) McKeegan K.S. … Watkins N.J. (Mol. Cell. Biol. 2007) 3 4
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 49

Products for ZNHIT6 Gene

Sources for ZNHIT6 Gene

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