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Aliases for ZNHIT6 Gene

Aliases for ZNHIT6 Gene

  • Zinc Finger HIT-Type Containing 6 2 3 5
  • Serologically Defined Breast Cancer Antigen NY-BR-75 3 4
  • Zinc Finger HIT Domain-Containing Protein 6 3 4
  • Zinc Finger, HIT Type 6 2 3
  • C1orf181 3 4
  • BCD1 3 4
  • Box C/D SnoRNA Essential 1 Homolog (S. Cerevisiae) 2
  • Chromosome 1 Open Reading Frame 181 2
  • Box C/D SnoRNA Essential 1 Homolog 3
  • Box C/D SnoRNA Protein 1 3
  • NY-BR-75 3

External Ids for ZNHIT6 Gene

Previous HGNC Symbols for ZNHIT6 Gene

  • C1orf181

Previous GeneCards Identifiers for ZNHIT6 Gene

  • GC01M085891
  • GC01M086118
  • GC01M084225

Summaries for ZNHIT6 Gene

GeneCards Summary for ZNHIT6 Gene

ZNHIT6 (Zinc Finger HIT-Type Containing 6) is a Protein Coding gene. GO annotations related to this gene include identical protein binding and enzyme binding.

UniProtKB/Swiss-Prot for ZNHIT6 Gene

  • Required for box C/D snoRNAs accumulation involved in snoRNA processing, snoRNA transport to the nucleolus and ribosome biogenesis.

Additional gene information for ZNHIT6 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNHIT6 Gene

Genomics for ZNHIT6 Gene

Regulatory Elements for ZNHIT6 Gene

Enhancers for ZNHIT6 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H085520 1.9 FANTOM5 Ensembl ENCODE dbSUPER 28.8 +184.4 184362 7 HDGF PKNOX1 ZNF133 FEZF1 BRCA1 ZNF2 ZNF121 FOS ATF7 DEK ZNHIT6 CYR61 DDAH1 C1orf52 ENSG00000282057 ENSG00000273264
GH01H085575 1.7 FANTOM5 ENCODE dbSUPER 24.7 +127.7 127663 11 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ODF2L ZNHIT6 ENSG00000232622 LOC100420166 C1orf52 BCL10 GC01P085583 CYR61
GH01H085604 1.9 FANTOM5 Ensembl ENCODE dbSUPER 16.2 +98.9 98911 9 PKNOX1 FOXA2 ARID4B SIN3A YY1 GLIS2 FOS REST GLIS1 RCOR2 CYR61 ZNHIT6 DDAH1 ODF2L ENSG00000230285 GC01P085628
GH01H085706 1.1 ENCODE 22.5 +0.3 257 2 HDGF PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNHIT6 ODF2L CYR61 DDAH1 PIR53460
GH01H085680 0.9 ENCODE 17.3 +27.1 27056 1 ELF3 TBP FOXA2 ARID4B RAD21 RARA CREM MIXL1 PPARG NFIL3 ZNHIT6 DDAH1 CYR61 PIR53460
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNHIT6 on UCSC Golden Path with GeneCards custom track

Promoters for ZNHIT6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000009274 463 2001 HDGF PKNOX1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9

Genomic Location for ZNHIT6 Gene

Chromosome:
1
Start:
85,649,423 bp from pter
End:
85,708,463 bp from pter
Size:
59,041 bases
Orientation:
Minus strand

Genomic View for ZNHIT6 Gene

Genes around ZNHIT6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNHIT6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNHIT6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNHIT6 Gene

Proteins for ZNHIT6 Gene

  • Protein details for ZNHIT6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NWK9-BCD1_HUMAN
    Recommended name:
    Box C/D snoRNA protein 1
    Protein Accession:
    Q9NWK9
    Secondary Accessions:
    • B2RBA1
    • B4DP13
    • D3DT20
    • Q9H278
    • Q9H3X3
    • Q9NWN0

    Protein attributes for ZNHIT6 Gene

    Size:
    470 amino acids
    Molecular mass:
    53918 Da
    Quaternary structure:
    • Interacts with FBL, SNU13, NOP58, NUFIP1, RUVBL1, RUVBL2 and TAF9.
    SequenceCaution:
    • Sequence=AAG48263.1; Type=Frameshift; Positions=365, 412, 416, 419, 432; Evidence={ECO:0000305}; Sequence=BAA91349.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNHIT6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNHIT6 Gene

Post-translational modifications for ZNHIT6 Gene

  • Ubiquitination at isoforms=2229, Lys362, and Lys424
  • Modification sites at PhosphoSitePlus

Other Protein References for ZNHIT6 Gene

No data available for DME Specific Peptides for ZNHIT6 Gene

Domains & Families for ZNHIT6 Gene

Gene Families for ZNHIT6 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ZNHIT6 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for ZNHIT6 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NWK9

UniProtKB/Swiss-Prot:

BCD1_HUMAN :
  • Belongs to the BCD1 family.
Family:
  • Belongs to the BCD1 family.
genes like me logo Genes that share domains with ZNHIT6: view

Function for ZNHIT6 Gene

Molecular function for ZNHIT6 Gene

UniProtKB/Swiss-Prot Function:
Required for box C/D snoRNAs accumulation involved in snoRNA processing, snoRNA transport to the nucleolus and ribosome biogenesis.

Phenotypes From GWAS Catalog for ZNHIT6 Gene

Gene Ontology (GO) - Molecular Function for ZNHIT6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001094 TFIID-class transcription factor binding IPI 17636026
GO:0005515 protein binding IPI 17636026
GO:0019899 enzyme binding IPI 23382074
GO:0042802 identical protein binding IPI 17636026
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNHIT6: view

Phenotypes for ZNHIT6 Gene

genes like me logo Genes that share phenotypes with ZNHIT6: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ZNHIT6
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNHIT6 Gene

Localization for ZNHIT6 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNHIT6 gene
Compartment Confidence
extracellular 5
cytosol 4
nucleus 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear speckles (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNHIT6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 19056867
GO:0070761 pre-snoRNP complex IDA 17636026
genes like me logo Genes that share ontologies with ZNHIT6: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ZNHIT6 Gene

Pathways & Interactions for ZNHIT6 Gene

SuperPathways for ZNHIT6 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNHIT6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000492 box C/D snoRNP assembly IMP 17636026
GO:0042254 ribosome biogenesis IEA --
GO:0048254 snoRNA localization IMP 17636026
GO:0051259 protein oligomerization IMP 17636026
genes like me logo Genes that share ontologies with ZNHIT6: view

No data available for Pathways by source and SIGNOR curated interactions for ZNHIT6 Gene

Drugs & Compounds for ZNHIT6 Gene

No Compound Related Data Available

Transcripts for ZNHIT6 Gene

mRNA/cDNA for ZNHIT6 Gene

Unigene Clusters for ZNHIT6 Gene

Zinc finger, HIT-type containing 6:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ZNHIT6
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for ZNHIT6 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
SP1:
SP2:

Relevant External Links for ZNHIT6 Gene

GeneLoc Exon Structure for
ZNHIT6
ECgene alternative splicing isoforms for
ZNHIT6

Expression for ZNHIT6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNHIT6 Gene

Protein differential expression in normal tissues from HIPED for ZNHIT6 Gene

This gene is overexpressed in Lung (43.3), Liver (13.9), and Fetal Liver (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZNHIT6 Gene



Protein tissue co-expression partners for ZNHIT6 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNHIT6 Gene:

ZNHIT6

SOURCE GeneReport for Unigene cluster for ZNHIT6 Gene:

Hs.5111

Evidence on tissue expression from TISSUES for ZNHIT6 Gene

  • Liver(4.2)
  • Nervous system(2.2)
genes like me logo Genes that share expression patterns with ZNHIT6: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNHIT6 Gene

Orthologs for ZNHIT6 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ZNHIT6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNHIT6 33 34
  • 99.65 (n)
cow
(Bos Taurus)
Mammalia ZNHIT6 33 34
  • 86.02 (n)
dog
(Canis familiaris)
Mammalia ZNHIT6 33 34
  • 84.63 (n)
mouse
(Mus musculus)
Mammalia Znhit6 33 16 34
  • 79.21 (n)
rat
(Rattus norvegicus)
Mammalia Znhit6 33
  • 77.95 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 68 (a)
OneToMany
-- 34
  • 54 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia ZNHIT6 34
  • 48 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZNHIT6 33 34
  • 68.87 (n)
lizard
(Anolis carolinensis)
Reptilia ZNHIT6 34
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia znhit6 33
  • 64.8 (n)
Str.6177 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.25224 33
zebrafish
(Danio rerio)
Actinopterygii ZNHIT6 34
  • 33 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004678 33
  • 50 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG1463 33 34
  • 44.35 (n)
worm
(Caenorhabditis elegans)
Secernentea zhit-3 34
  • 16 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes BCD1 34 36
  • 18 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.448 34
  • 31 (a)
OneToMany
-- 34
  • 27 (a)
OneToMany
Species where no ortholog for ZNHIT6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZNHIT6 Gene

ENSEMBL:
Gene Tree for ZNHIT6 (if available)
TreeFam:
Gene Tree for ZNHIT6 (if available)

Paralogs for ZNHIT6 Gene

No data available for Paralogs for ZNHIT6 Gene

Variants for ZNHIT6 Gene

Sequence variations from dbSNP and Humsavar for ZNHIT6 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
VAR_035721 A colorectal cancer sample
rs1000154701 -- 85,680,076(+) TGGCC(G/T)GAGCC intron-variant
rs1000231408 -- 85,673,908(+) TCTAA(C/T)TTCAT intron-variant
rs1000242561 -- 85,680,065(+) GCTGG(A/G)CGTGA intron-variant
rs1000398591 -- 85,666,003(+) AATTT(G/T)GTGAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNHIT6 Gene

Variant ID Type Subtype PubMed ID
nsv506942 OTHER sequence alteration 20534489
nsv509369 CNV insertion 20534489

Variation tolerance for ZNHIT6 Gene

Residual Variation Intolerance Score: 63.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.68; 46.00% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNHIT6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNHIT6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNHIT6 Gene

Disorders for ZNHIT6 Gene

Relevant External Links for ZNHIT6

Genetic Association Database (GAD)
ZNHIT6
Human Genome Epidemiology (HuGE) Navigator
ZNHIT6
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNHIT6

No disorders were found for ZNHIT6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNHIT6 Gene

Publications for ZNHIT6 Gene

  1. Humoral immunity to human breast cancer: antigen definition and quantitative analysis of mRNA expression. (PMID: 12747765) Scanlan MJ … Old LJ (Cancer immunity 2001) 2 3 4 60
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60
  3. A dynamic scaffold of pre-snoRNP factors facilitates human box C/D snoRNP assembly. (PMID: 17636026) McKeegan KS … Watkins NJ (Molecular and cellular biology 2007) 3 4 60
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 60
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60

Products for ZNHIT6 Gene

Sources for ZNHIT6 Gene

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