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Aliases for ZNHIT3 Gene

Aliases for ZNHIT3 Gene

  • Zinc Finger, HIT-Type Containing 3 2 3
  • Thyroid Hormone Receptor Interactor 3 2 3 4
  • TRIP3 3 4 6
  • Thyroid Receptor-Interacting Protein 3 3 4
  • TR-Interacting Protein 3 3 4
  • Zinc Finger, HIT Type 3 2 3
  • HNF-4a Coactivator 3 4
  • TRIP-3 3 4
  • Zinc Finger HIT Domain-Containing Protein 3 3
  • Thyroid Receptor Interacting Protein 3 3
  • Zinc Finger, HIT Domain Containing 3 3

External Ids for ZNHIT3 Gene

Previous HGNC Symbols for ZNHIT3 Gene

  • TRIP3

Previous GeneCards Identifiers for ZNHIT3 Gene

  • GC17P031917
  • GC17P034842
  • GC17P030779

Summaries for ZNHIT3 Gene

GeneCards Summary for ZNHIT3 Gene

ZNHIT3 (Zinc Finger, HIT-Type Containing 3) is a Protein Coding gene. GO annotations related to this gene include thyroid hormone receptor binding.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNHIT3 Gene

Genomics for ZNHIT3 Gene

Regulatory Elements for ZNHIT3 Gene

Genomic Location for ZNHIT3 Gene

36,486,627 bp from pter
36,499,310 bp from pter
12,684 bases
Plus strand

Genomic View for ZNHIT3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNHIT3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNHIT3 Gene

Proteins for ZNHIT3 Gene

  • Protein details for ZNHIT3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger HIT domain-containing protein 3
    Protein Accession:
    Secondary Accessions:
    • A8K493
    • K7EQP1
    • Q8WVJ3

    Protein attributes for ZNHIT3 Gene

    155 amino acids
    Molecular mass:
    17607 Da
    Quaternary structure:
    • Thyroid receptor interacting proteins (TRIPs) specifically interact with the ligand binding domain of the thyroid receptor (TR). Requires the presence of thyroid hormone for its interaction

    Three dimensional structures from OCA and Proteopedia for ZNHIT3 Gene

    Alternative splice isoforms for ZNHIT3 Gene


neXtProt entry for ZNHIT3 Gene

Proteomics data for ZNHIT3 Gene at MOPED

Post-translational modifications for ZNHIT3 Gene

  • Ubiquitination at Lys5, Lys93, Lys123, and Lys125
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ZNHIT3 Gene

Domains for ZNHIT3 Gene

Gene Families for ZNHIT3 Gene

  • ZNHIT :Zinc fingers, HIT-type

Protein Domains for ZNHIT3 Gene


Suggested Antigen Peptide Sequences for ZNHIT3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q15649
  • Contains 1 HIT-type zinc finger.
genes like me logo Genes that share domains with ZNHIT3: view

Function for ZNHIT3 Gene

Gene Ontology (GO) - Molecular Function for ZNHIT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046872 metal ion binding IEA --
GO:0046966 thyroid hormone receptor binding TAS 7776974
genes like me logo Genes that share ontologies with ZNHIT3: view

Phenotypes for ZNHIT3 Gene

GenomeRNAi human phenotypes for ZNHIT3:
genes like me logo Genes that share phenotypes with ZNHIT3: view

Animal Model Products

miRNA for ZNHIT3 Gene

miRTarBase miRNAs that target ZNHIT3

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNHIT3

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ZNHIT3 Gene

Localization for ZNHIT3 Gene

Subcellular locations from

Jensen Localization Image for ZNHIT3 Gene COMPARTMENTS Subcellular localization image for ZNHIT3 gene
Compartment Confidence
extracellular 2
cytosol 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for ZNHIT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular NAS 7776974
genes like me logo Genes that share ontologies with ZNHIT3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ZNHIT3 Gene

Pathways for ZNHIT3 Gene

SuperPathways for ZNHIT3 Gene

No Data Available

Interacting Proteins for ZNHIT3 Gene

Selected Interacting proteins: Q15649-ZNHI3_HUMAN for ZNHIT3 Gene via I2D

Gene Ontology (GO) - Biological Process for ZNHIT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated TAS 7776974
genes like me logo Genes that share ontologies with ZNHIT3: view

No data available for Pathways by source for ZNHIT3 Gene

Transcripts for ZNHIT3 Gene

Unigene Clusters for ZNHIT3 Gene

Zinc finger, HIT-type containing 3:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNHIT3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNHIT3 Gene

No ASD Table

Relevant External Links for ZNHIT3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNHIT3 Gene

mRNA expression in normal human tissues for ZNHIT3 Gene

Protein differential expression in normal tissues for ZNHIT3 Gene

This gene is overexpressed in Lung (50.3) and Bone marrow mesenchymal stem cell (18.7).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for ZNHIT3 Gene

SOURCE GeneReport for Unigene cluster for ZNHIT3 Gene Hs.2210

genes like me logo Genes that share expressions with ZNHIT3: view

Expression partners for ZNHIT3 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNHIT3 Gene

Orthologs for ZNHIT3 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNHIT3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ZNHIT3 35
  • 85.28 (n)
  • 85.06 (a)
(Canis familiaris)
Mammalia ZNHIT3 35
  • 87.1 (n)
  • 87.74 (a)
(Mus musculus)
Mammalia Znhit3 35
  • 81.9 (n)
  • 80.79 (a)
Znhit3 16
(Pan troglodytes)
Mammalia ZNHIT3 35
  • 99.35 (n)
  • 99.35 (a)
(Rattus norvegicus)
Mammalia Znhit3 35
  • 82.43 (n)
  • 80.41 (a)
(Gallus gallus)
Aves ZNHIT3 35
  • 61.2 (n)
  • 56.25 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia znhit3 35
  • 56.72 (n)
  • 50 (a)
(Danio rerio)
Actinopterygii znhit3 35
  • 56.79 (n)
  • 54.07 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011858 35
  • 51.63 (n)
  • 45.11 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG8204 35
  • 47.95 (n)
  • 43.08 (a)
Species with no ortholog for ZNHIT3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNHIT3 Gene

Gene Tree for ZNHIT3 (if available)
Gene Tree for ZNHIT3 (if available)

Paralogs for ZNHIT3 Gene

genes like me logo Genes that share paralogs with ZNHIT3: view

No data available for Paralogs for ZNHIT3 Gene

Variants for ZNHIT3 Gene

Sequence variations from dbSNP and Humsavar for ZNHIT3 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs1542611 -- 36,492,592(+) GACAG(G/T)TTCTT intron-variant
rs1872064 -- 36,487,055(+) TTGGC(C/G)TGCGC intron-variant
rs2277662 -- 36,493,853(+) CTGTT(C/G)AAGTA intron-variant
rs2306589 -- 36,493,030(+) TAGCC(C/T)TGAGC intron-variant
rs3830269 -- 36,492,952(+) AAGTC(-/GAAAG)CGAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNHIT3 Gene

Variant ID Type Subtype PubMed ID
nsv428340 CNV Gain 18775914
dgv946e1 CNV Complex 17122850
dgv948e1 CNV Complex 17122850
dgv122e55 CNV Gain 17911159
esv2751645 CNV Gain 17911159
nsv526727 CNV Gain 19592680
nsv469796 CNV Gain 16826518
nsv471697 CNV Gain 15918152
essv6619 CNV CNV 17122850
nsv469853 CNV Complex 16826518
nsv457734 CNV Gain 19166990
nsv516100 CNV Gain+Loss 19592680

Relevant External Links for ZNHIT3 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNHIT3 Gene

Disorders for ZNHIT3 Gene

(1) University of Copenhagen DISEASES for ZNHIT3 Gene

genes like me logo Genes that share disorders with ZNHIT3: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships , Genatlas and External Links for ZNHIT3 Gene

Publications for ZNHIT3 Gene

  1. Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor. (PMID: 7776974) Lee J.W. … Moore D.D. (Mol. Endocrinol. 1995) 2 3 4
  2. Thyroid hormone receptor interacting protein 3 (trip3) is a novel coactivator of hepatocyte nuclear factor-4alpha. (PMID: 11916906) Iwahashi H. … Matsuzawa Y. (Diabetes 2002) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4
  5. [Relationship between expression of GYPC and TRIP3 genes and prognosis of acute lymphoblastic leukemia in children]. (PMID: 19149918) Zhang J.B. … Guo X.S. (Zhongguo Dang Dai Er Ke Za Zhi 2009) 3

Products for ZNHIT3 Gene

Sources for ZNHIT3 Gene

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