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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZNHIT3 Gene

protein-coding   GIFtS: 48
GCID: GC17P034842

Zinc Finger, HIT-Type Containing 3

(Previous names: thyroid hormone receptor interactor 3, zinc finger, HIT...)
(Previous symbol: TRIP3)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Zinc Finger, HIT-Type Containing 31 2     HNF-4a Coactivator2 3
TRIP31 2 3 5     TR-Interacting Protein 32 3
Thyroid Hormone Receptor Interactor 31 2 3     Thyroid Receptor Interacting Protein 32
Zinc Finger, HIT Type 31 2     Zinc Finger HIT Domain-Containing Protein 32
Thyroid Receptor-Interacting Protein 32 3     Zinc Finger, HIT Domain Containing 32
TRIP-32 3     

External Ids:    HGNC: 123091   Entrez Gene: 93262   Ensembl: ENSG000001082787   OMIM: 6045005   UniProtKB: Q156493   

Export aliases for ZNHIT3 gene to outside databases

Previous GC identifers: GC17P031917 GC17P030779


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ZNHIT3 Gene: 
ZNHIT3 (zinc finger, HIT-type containing 3) is a protein-coding gene. Diseases associated with ZNHIT3 include congenital diaphragmatic hernia, and thyroiditis. GO annotations related to this gene include thyroid hormone receptor binding and metal ion binding.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.2  NT_010783.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZNHIT3 gene promoter:
         HNF-4alpha2   HNF-4alpha1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNHIT3 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZNHIT3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNHIT3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q12   Ensembl cytogenetic band:  17q12   HGNC cytogenetic band: 17q21.1

ZNHIT3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNHIT3 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P034842:  view genomic region     (about GC identifiers)

Start:
34,842,473 bp from pter      End:
34,855,154 bp from pter
Size:
12,682 bases      Orientation:
plus strand

1 alternative location:
Chr17+,NW_003315949 371,379-380,568     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZNHI3_HUMAN, Q15649 (See protein sequence)
Recommended Name: Zinc finger HIT domain-containing protein 3  
Size: 155 amino acids; 17607 Da
Subunit: Thyroid receptor interacting proteins (TRIPs) specifically interact with the ligand binding domain of the
thyroid receptor (TR). Requires the presence of thyroid hormone for its interaction
1 PDB 3D structure from and Proteopedia for ZNHIT3:
2YQQ (3D)    
Secondary accessions: A8K493 Q8WVJ3

Explore the universe of human proteins at neXtProt for ZNHIT3: NX_Q15649

Explore proteomics data for ZNHIT3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q15649

  • ZNHIT3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ZNHIT3 Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_001268361.1  NP_001268362.1  NP_001268363.1  NP_004764.1  

    ENSEMBL proteins: 
     ENSP00000465681   ENSP00000225410   ENSP00000465693   ENSP00000467184   ENSP00000467917  
     ENSP00000467894   ENSP00000466628   ENSP00000467835   ENSP00000464706   ENSP00000467550  

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    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular NAS7776974

    ZNHIT3 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZNHIT: Zinc fingers, HIT-type

    1 InterPro protein domain:
     IPR007529 Znf_HIT

    Graphical View of Domain Structure for InterPro Entry Q15649

    ProtoNet protein and cluster: Q15649

    1 Blocks protein domain: IPB007529 HIT Zn-finger

    UniProtKB/Swiss-Prot: ZNHI3_HUMAN, Q15649
    Similarity: Contains 1 HIT-type zinc finger


    ZNHIT3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0046872metal ion binding IEA--
    GO:0046966thyroid hormone receptor binding TAS7776974
         
    ZNHIT3 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for ZNHIT3:
     Decreased POU5F1-GFP protein e  Synthetic lethal with Ras 

    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNHIT3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    5/14 Interacting proteins for ZNHIT3 (Q156493 ENSP000002254104) via UniProtKB, MINT, STRING, and/or I2D (see all 14)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ESR2Q927313, ENSP000003439254I2D: score=1 STRING: ENSP00000343925
    PITX2Q996973, ENSP000003041694I2D: score=1 STRING: ENSP00000304169
    HNF4AP412353, ENSP000003129874I2D: score=2 STRING: ENSP00000312987
    RXRAP197933, ENSP000004196924I2D: score=1 STRING: ENSP00000419692
    THRBP108283, ENSP000003488274I2D: score=1 STRING: ENSP00000348827
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-dependent TAS7776974

    ZNHIT3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZNHIT3 (ZNHI3)

    Search CenterWatch for drugs/clinical trials and news about ZNHIT3 / ZNHI3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZNHIT3 gene (5 alternative transcripts): 
    NM_001033577.1  NM_001281432.1  NM_001281433.1  NM_001281434.1  NM_004773.3  

    Unigene Cluster for ZNHIT3:

    Zinc finger, HIT-type containing 3
    Hs.2210  [show with all ESTs]
    Unigene Representative Sequence: AK308583
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000490126 ENST00000225410(uc010cus.1 uc002hms.1 uc002hmt.1 uc010cut.1)
    ENST00000588253 ENST00000592684 ENST00000586660 ENST00000592616 ENST00000590827
    ENST00000590858 ENST00000588357 ENST00000590424 ENST00000588902 ENST00000591067

    miRNA
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    hsa-miR-141 hsa-miR-200a
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    Inhib. RNA
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    Additional mRNA sequence: 

    AF400652.1 AK290858.1 AK308583.1 AK310022.1 BC017931.1 BC105608.1 L40410.1 

    14 DOTS entries:

    DT.99976135  DT.446418  DT.423511  DT.121002694  DT.91820265  DT.100020445  DT.100677229  DT.97855154 
    DT.100826426  DT.121002681  DT.95373356  DT.120941836  DT.40286630  DT.40305723 

    24/345 AceView cDNA sequences (see all 345):

    AI217130 Z40838 BM977322 CF529210 BM128035 BU664946 BE409038 BM562484 
    AA534840 BM683449 BU169291 BQ003462 BQ439864 BM982929 AI879491 CK819116 
    BQ011663 BG913516 BX279874 BU626179 AI082197 L40410 BU738121 AA258703 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for ZNHIT3    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b
    SP1:                                    
    SP2:              -                     


    ECgene alternative splicing isoforms for ZNHIT3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZNHIT3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTCAGGCAG
    ZNHIT3 Expression
    About this image


    See ZNHIT3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZNHIT3

    SOURCE GeneReport for Unigene cluster: Hs.2210
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for ZNHIT3 gene from 5/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Znhit31 , 5 zinc finger, HIT type 31, 5 81.9(n)1
    80.79(a)1
      11 (51.34 cM)5
    4488501  NM_001005223.21  NP_001005223.11 
     849109505 
    chicken
    (Gallus gallus)
    Aves LOC1008590831 zinc finger HIT domain-containing protein 3-like 61.2(n)
    56.25(a)
      100859083  XM_003642411.1  XP_003642459.1 
    lizard
    (Anolis carolinensis)
    Reptilia ZNHIT36
    zinc finger, HIT-type containing 3
    39(a)
    1 ↔ 1
    GL344386.1(25692-31217)
    zebrafish
    (Danio rerio)
    Actinopterygii znhit31 zinc finger, HIT-type containing 3 56.69(n)
    53.28(a)
      393243  NM_200273.1  NP_956567.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG82041 CG8204 47.95(n)
    43.08(a)
      36728  NM_137206.2  NP_611050.1 


    ENSEMBL Gene Tree for ZNHIT3 (if available)
    TreeFam Gene Tree for ZNHIT3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZNHIT3 gene
    18/37 SIMAP similar genes for ZNHIT3 using alignment to 9 protein entries:     ZNHI3_HUMAN (see all proteins) (see all similar genes):
    IFT122    FAM3A    WDR6    KLHDC1    ZNF23    ZNF568
    C19orf25    CNOT2    MKRN1    SENP7    ZNF738    LRTOMT
    NDUFS7    COX7A2    FANCA    PSD3    ANAPC11    SPSB4

    ZNHIT3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/254 SNPs in ZNHIT3 are shown (see all 254)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1898863681,2
    --34840495(+) CACCAC/TACCCA 1 -- us2k10--------
    rs1817502151,2
    --34840631(+) CACTGC/TGCCTG 1 -- us2k10--------
    rs1841175501,2
    C--34840661(+) AAGACA/GGGGTC 1 -- us2k10--------
    rs347130241,2
    C,F--34840664(+) ACGGGG/ATCTCT 1 -- us2k17Minor allele frequency- A:0.43NA EA 250
    rs1423869591,2
    --34840815(+) CACAGA/GATTTA 1 -- us2k10--------
    rs1172314641,2
    F--34840817(+) CAGGAT/CTTAAA 1 -- us2k11Minor allele frequency- C:0.01EA 120
    rs1432904991,2
    C--34840952(+) ACTGGA/GCCTGT 1 -- us2k10--------
    rs1482975271,2
    --34841080(+) TGGGTC/TGCCAC 1 -- us2k10--------
    rs1163486441,2
    C,F--34841081(+) GGGTCG/ACCACG 1 -- us2k11Minor allele frequency- A:0.01WA 118
    rs1885103971,2
    --34841183(+) CATGCA/GGTCCA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ZNHIT3 (34842473 - 34855154 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/12 variations for ZNHIT3 (see all 12):    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv122e55CNV Gain17911159
    nsv526727CNV Gain19592680
    nsv428340CNV Gain18775914
    nsv469796CNV Gain16826518
    esv2751645CNV Gain17911159
    nsv471697CNV Gain15918152
    nsv457734CNV Gain19166990
    nsv516100CNV Gain+Loss19592680
    essv6619CNV CNV17122850
    nsv469853CNV Complex16826518

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 604500    OMIM disorders: --

    7 diseases for ZNHIT3:    About MalaCards
    congenital diaphragmatic hernia    thyroiditis    hernia    acute lymphoblastic leukemia
    lymphoblastic leukemia    hepatocellular carcinoma    leukemia

    1 disease from the University of Copenhagen DISEASES database for ZNHIT3:
    Congenital diaphragmatic hernia

    ZNHIT3 for disorders           About GeneDecksing


    Export disorders for ZNHIT3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZNHIT3 gene, integrated from 9 sources (see all 18):
    (articles sorted by number of sources associating them with ZNHIT3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor. (PubMed id 7776974)1, 2, 3 Lee J.W....Moore D.D. (1995)
    2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Thyroid hormone receptor interacting protein 3 (trip3) is a novel coactivator of hepatocyte nuclear factor-4alpha. (PubMed id 11916906)1, 2 Iwahashi H.... Matsuzawa Y. (2002)
    5. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    6. Toward an understanding of the protein interaction net work of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (2011)
    7. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
    8. Systematic analysis of human protein complexes identi fies chromosome segregation proteins. (PubMed id 20360068)1 Hutchins J.R....Peters J.M. (2010)
    9. An atlas of combinatorial transcriptional regulation in mouse and man. (PubMed id 20211142)1 Ravasi T....Hayashizaki Y. (2010)
    10. [Relationship between expression of GYPC and TRIP3 genes and prognosis of acute lymphoblastic leukemia in children] (PubMed id 19149918)1 Zhang J.B....Guo X.S. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9326 HGNC: 12309 AceView: TRIP3 Ensembl:ENSG00000108278 euGenes: HUgn9326
    ECgene: ZNHIT3 H-InvDB: ZNHIT3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZNHIT3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZNHIT3 gene:
    Search GeneIP for patents involving ZNHIT3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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