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ZNHIT3 Gene

protein-coding   GIFtS: 50
GCID: GC17P034842

Zinc Finger, HIT-Type Containing 3

(Previous names: thyroid hormone receptor interactor 3, zinc finger, HIT...)
(Previous symbol: TRIP3)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger, HIT-Type Containing 31 2     HNF-4a Coactivator2 3
TRIP31 2 3 5     TR-Interacting Protein 32 3
Thyroid Hormone Receptor Interactor 31 2 3     Thyroid Receptor Interacting Protein 32
Zinc Finger, HIT Type 31 2     Zinc Finger HIT Domain-Containing Protein 32
Thyroid Receptor-Interacting Protein 32 3     Zinc Finger, HIT Domain Containing 32
TRIP-32 3     

External Ids:    HGNC: 123091   Entrez Gene: 93262   Ensembl: ENSG000001082787   OMIM: 6045005   UniProtKB: Q156493   

Export aliases for ZNHIT3 gene to outside databases

Previous GC identifers: GC17P031917 GC17P030779


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZNHIT3 Gene:
ZNHIT3 (zinc finger, HIT-type containing 3) is a protein-coding gene. GO annotations related to this gene include thyroid hormone receptor binding.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NC_018928.2  NT_010783.16  NT_187614.1  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZNHIT3 gene promoter:
         HNF-4alpha2   HNF-4alpha1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNHIT3 promoter sequence
   Search Chromatin IP Primers for ZNHIT3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNHIT3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q12   Ensembl cytogenetic band:  17q12   HGNC cytogenetic band: 17q21.1

ZNHIT3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNHIT3 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P034842:  view genomic region     (about GC identifiers)

Start:
34,842,473 bp from pter      End:
34,855,154 bp from pter
Size:
12,682 bases      Orientation:
plus strand

1 alternative location:
Chr17+,NW_003315949 371,379-380,568     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ZNHI3_HUMAN, Q15649 (See protein sequence)
Recommended Name: Zinc finger HIT domain-containing protein 3  
Size: 155 amino acids; 17607 Da
Subunit: Thyroid receptor interacting proteins (TRIPs) specifically interact with the ligand binding domain of the
thyroid receptor (TR). Requires the presence of thyroid hormone for its interaction
1 PDB 3D structure from and Proteopedia for ZNHIT3:
2YQQ (3D)    
Secondary accessions: A8K493 Q8WVJ3

Explore the universe of human proteins at neXtProt for ZNHIT3: NX_Q15649

Explore proteomics data for ZNHIT3 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys5, Lys93, Lys123, Lys125
  • Modification sites at PhosphoSitePlus

  • See ZNHIT3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001268361.1  NP_001268362.1  NP_001268363.1  NP_004764.1  

    ENSEMBL proteins: 
     ENSP00000465681   ENSP00000225410   ENSP00000465693   ENSP00000467184   ENSP00000467917  
     ENSP00000467894   ENSP00000466628   ENSP00000467835   ENSP00000464706   ENSP00000467550  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNHIT: Zinc fingers, HIT-type

    1 InterPro protein domain:
     IPR007529 Znf_HIT

    Graphical View of Domain Structure for InterPro Entry Q15649

    ProtoNet protein and cluster: Q15649

    1 Blocks protein domain: IPB007529 HIT Zn-finger

    UniProtKB/Swiss-Prot: ZNHI3_HUMAN, Q15649
    Similarity: Contains 1 HIT-type zinc finger


    Find genes that share domains with ZNHIT3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0046872metal ion binding IEA--
    GO:0046966thyroid hormone receptor binding TAS7776974
         
    Find genes that share ontologies with ZNHIT3           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for ZNHIT3:
     Decreased POU5F1-GFP protein e  Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ZNHIT3
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    miRTarBase miRNAs that target ZNHIT3:
    hsa-mir-192-5p (MIRT026564), hsa-mir-378a-3p (MIRT043888), hsa-mir-215-5p (MIRT024305)

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    2 qRT-PCR Assays for microRNAs that regulate ZNHIT3:
    hsa-miR-141 hsa-miR-200a
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular2
    cytosol1
    mitochondrion1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular NAS7776974

    Find genes that share ontologies with ZNHIT3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNHIT3
    Interactions:

        Search GeneGlobe Interaction Network for ZNHIT3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    Selected Interacting proteins for ZNHIT3 (Q156493 ENSP000002254104) via UniProtKB, MINT, STRING, and/or I2D (see all 14)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ESR2Q927313, ENSP000003439254I2D: score=1 STRING: ENSP00000343925
    PITX2Q996973, ENSP000003041694I2D: score=1 STRING: ENSP00000304169
    HNF4AP412353, ENSP000003129874I2D: score=2 STRING: ENSP00000312987
    RXRAP197933, ENSP000004196924I2D: score=1 STRING: ENSP00000419692
    THRBP108283, ENSP000003488274I2D: score=1 STRING: ENSP00000348827
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-templated TAS7776974

    Find genes that share ontologies with ZNHIT3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZNHIT3 (ZNHI3)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ZNHIT3 gene (5 alternative transcripts): 
    NM_001033577.1  NM_001281432.1  NM_001281433.1  NM_001281434.1  NM_004773.3  

    Unigene Cluster for ZNHIT3:

    Zinc finger, HIT-type containing 3
    Hs.2210  [show with all ESTs]
    Unigene Representative Sequence: AK308583
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000490126 ENST00000225410(uc010cus.1 uc002hms.1 uc002hmt.1 uc010cut.1)
    ENST00000588253 ENST00000592684 ENST00000586660 ENST00000592616 ENST00000590827
    ENST00000590858 ENST00000588357 ENST00000590424 ENST00000588902 ENST00000591067

    miRNA
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    2 qRT-PCR Assays for microRNAs that regulate ZNHIT3:
    hsa-miR-141 hsa-miR-200a
    SwitchGear 3'UTR luciferase reporter plasmidZNHIT3 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AF400652.1 AK290858.1 AK308583.1 AK310022.1 BC017931.1 BC105608.1 L40410.1 

    14 DOTS entries:

    DT.99976135  DT.446418  DT.423511  DT.121002694  DT.91820265  DT.100020445  DT.100677229  DT.97855154 
    DT.100826426  DT.121002681  DT.95373356  DT.120941836  DT.40286630  DT.40305723 

    Selected AceView cDNA sequences (see all 345):

    AI572259 AA534840 BG913516 BM720331 BE253046 AA554340 AA854985 BU622808 
    CA865499 AI005604 BM992618 BM128035 BQ893966 AA039697 BQ771907 BC017931 
    CA844264 AI016243 BM985038 BU169291 CF529300 AA512895 BI754761 AI217130 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for ZNHIT3    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b
    SP1:                                    
    SP2:              -                     


    ECgene alternative splicing isoforms for ZNHIT3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZNHIT3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTCAGGCAG
    ZNHIT3 Expression
    About this image

    ZNHIT3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZNHIT3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.2210
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ZNHIT3 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Znhit31 , 5 zinc finger, HIT type 31, 5 81.9(n)1
    80.79(a)1
      11 (51.34 cM)5
    4488501  NM_001005223.21  NP_001005223.11 
     849109505 
    chicken
    (Gallus gallus)
    Aves ZNHIT31 zinc finger, HIT-type containing 3 61.2(n)
    56.25(a)
      100859083  XM_003642411.2  XP_003642459.2 
    lizard
    (Anolis carolinensis)
    Reptilia ZNHIT36
    zinc finger, HIT-type containing 3
    42(a)
    1 ↔ 1
    GL344386.1(25692-31217)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia znhit31 zinc finger, HIT-type containing 3 56.72(n)
    50(a)
      733819  NM_001045581.1  NP_001039046.1 
    zebrafish
    (Danio rerio)
    Actinopterygii znhit31 zinc finger, HIT-type containing 3 56.79(n)
    54.07(a)
      393243  NM_200273.1  NP_956567.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG82041 CG8204 47.95(n)
    43.08(a)
      36728  NM_137206.2  NP_611050.1 


    ENSEMBL Gene Tree for ZNHIT3 (if available)
    TreeFam Gene Tree for ZNHIT3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZNHIT3 gene
    Selected SIMAP similar genes for ZNHIT3 using alignment to 9 protein entries:     ZNHI3_HUMAN (see all proteins) (see all similar genes):
    IFT122    FAM3A    WDR6    KLHDC1    ZNF23    ZNF568
    C19orf25    CNOT2    MKRN1    SENP7    ZNF738    LRTOMT
    ECD    NDUFS7    COX7A2    FANCA    PSD3    ANAPC11

    Find genes that share paralogs with ZNHIT3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZNHIT3 (see all 254)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1898863681,2
    --34840495(+) CACCAC/TACCCA 1 -- us2k10--------
    rs1817502151,2
    --34840631(+) CACTGC/TGCCTG 1 -- us2k10--------
    rs1841175501,2
    C--34840661(+) AAGACA/GGGGTC 1 -- us2k10--------
    rs347130241,2
    C,F--34840664(+) ACGGGG/ATCTCT 1 -- us2k17Minor allele frequency- A:0.43NA EA 250
    rs1423869591,2
    --34840815(+) CACAGA/GATTTA 1 -- us2k10--------
    rs1172314641,2
    F--34840817(+) CAGGAT/CTTAAA 1 -- us2k11Minor allele frequency- C:0.01EA 120
    rs1432904991,2
    C--34840952(+) ACTGGA/GCCTGT 1 -- us2k10--------
    rs1482975271,2
    --34841080(+) TGGGTC/TGCCAC 1 -- us2k10--------
    rs1163486441,2
    C,F--34841081(+) GGGTCG/ACCACG 1 -- us2k11Minor allele frequency- A:0.01WA 118
    rs1885103971,2
    --34841183(+) CATGCA/GGTCCA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ZNHIT3 (34842473 - 34855154 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for ZNHIT3 (see all 12):    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv122e55CNV Gain17911159
    nsv526727CNV Gain19592680
    nsv428340CNV Gain18775914
    nsv469796CNV Gain16826518
    esv2751645CNV Gain17911159
    nsv471697CNV Gain15918152
    nsv457734CNV Gain19166990
    nsv516100CNV Gain+Loss19592680
    essv6619CNV CNV17122850
    nsv469853CNV Complex16826518

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604500    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for ZNHIT3:
    Congenital diaphragmatic hernia

    Find genes that share disorders with ZNHIT3           About GenesLikeMe


    Export disorders for ZNHIT3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZNHIT3 gene, integrated from 10 sources (see all 18):
    (articles sorted by number of sources associating them with ZNHIT3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor. (PubMed id 7776974)1, 2, 3 Lee J.W.... Moore D.D. (Mol. Endocrinol. 1995)
    2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Thyroid hormone receptor interacting protein 3 (trip3) is a novel coactivator of hepatocyte nuclear factor-4alpha. (PubMed id 11916906)1, 2 Iwahashi H.... Matsuzawa Y. (Diabetes 2002)
    5. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    6. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)
    7. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (Sci. Signal. 2011)
    8. Systematic analysis of human protein complexes identifies chromosome segregation proteins. (PubMed id 20360068)1 Hutchins J.R.... Peters J.M. (Science 2010)
    9. An atlas of combinatorial transcriptional regulation in mouse and man. (PubMed id 20211142)1 Ravasi T....Hayashizaki Y. (Cell 2010)
    10. [Relationship between expression of GYPC and TRIP3 genes and prognosis of acute lymphoblastic leukemia in children]. (PubMed id 19149918)1 Zhang J.B....Guo X.S. (Zhongguo Dang Dai Er Ke Za Zhi 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9326 HGNC: 12309 AceView: TRIP3 Ensembl:ENSG00000108278 euGenes: HUgn9326
    ECgene: ZNHIT3 H-InvDB: ZNHIT3

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZNHIT3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZNHIT3 gene:
    Search GeneIP for patents involving ZNHIT3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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