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Aliases for ZNHIT3 Gene

Aliases for ZNHIT3 Gene

  • Zinc Finger, HIT-Type Containing 3 2 3
  • Thyroid Hormone Receptor Interactor 3 2 3 4
  • Thyroid Receptor-Interacting Protein 3 3 4
  • TR-Interacting Protein 3 3 4
  • Zinc Finger, HIT Type 3 2 3
  • HNF-4a Coactivator 3 4
  • TRIP-3 3 4
  • TRIP3 3 4
  • Thyroid Receptor Interacting Protein 3 3
  • Zinc Finger, HIT Domain Containing 3 3

External Ids for ZNHIT3 Gene

Previous HGNC Symbols for ZNHIT3 Gene

  • TRIP3

Previous GeneCards Identifiers for ZNHIT3 Gene

  • GC17P031917
  • GC17P034842
  • GC17P030779

Summaries for ZNHIT3 Gene

GeneCards Summary for ZNHIT3 Gene

ZNHIT3 (Zinc Finger, HIT-Type Containing 3) is a Protein Coding gene. GO annotations related to this gene include thyroid hormone receptor binding.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNHIT3 Gene

Genomics for ZNHIT3 Gene

Regulatory Elements for ZNHIT3 Gene

Genomic Location for ZNHIT3 Gene

Chromosome:
17
Start:
36,486,627 bp from pter
End:
36,499,310 bp from pter
Size:
12,684 bases
Orientation:
Plus strand

Genomic View for ZNHIT3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNHIT3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNHIT3 Gene

Proteins for ZNHIT3 Gene

  • Protein details for ZNHIT3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15649-ZNHI3_HUMAN
    Recommended name:
    Zinc finger HIT domain-containing protein 3
    Protein Accession:
    Q15649
    Secondary Accessions:
    • A8K493
    • K7EQP1
    • Q8WVJ3

    Protein attributes for ZNHIT3 Gene

    Size:
    155 amino acids
    Molecular mass:
    17607 Da
    Quaternary structure:
    • Thyroid receptor interacting proteins (TRIPs) specifically interact with the ligand binding domain of the thyroid receptor (TR). Requires the presence of thyroid hormone for its interaction

    Three dimensional structures from OCA and Proteopedia for ZNHIT3 Gene

    Alternative splice isoforms for ZNHIT3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNHIT3 Gene

Proteomics data for ZNHIT3 Gene at MOPED

Post-translational modifications for ZNHIT3 Gene

  • Ubiquitination at Lys 5, Lys 93, and Lys 123
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ZNHIT3 Gene

Domains & Families for ZNHIT3 Gene

Gene Families for ZNHIT3 Gene

Protein Domains for ZNHIT3 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for ZNHIT3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q15649

UniProtKB/Swiss-Prot:

ZNHI3_HUMAN :
  • Contains 1 HIT-type zinc finger.
Similarity:
  • Contains 1 HIT-type zinc finger.
genes like me logo Genes that share domains with ZNHIT3: view

Function for ZNHIT3 Gene

Gene Ontology (GO) - Molecular Function for ZNHIT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25170085
GO:0046872 metal ion binding IEA --
GO:0046966 thyroid hormone receptor binding TAS 7776974
genes like me logo Genes that share ontologies with ZNHIT3: view
genes like me logo Genes that share phenotypes with ZNHIT3: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNHIT3

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNHIT3 Gene

Localization for ZNHIT3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNHIT3 Gene COMPARTMENTS Subcellular localization image for ZNHIT3 gene
Compartment Confidence
nucleus 2

Gene Ontology (GO) - Cellular Components for ZNHIT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular NAS 7776974
genes like me logo Genes that share ontologies with ZNHIT3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ZNHIT3 Gene

Pathways & Interactions for ZNHIT3 Gene

SuperPathways for ZNHIT3 Gene

No Data Available

Interacting Proteins for ZNHIT3 Gene

Selected Interacting proteins: Q15649-ZNHI3_HUMAN for ZNHIT3 Gene via I2D UniProtKB

Gene Ontology (GO) - Biological Process for ZNHIT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated TAS 7776974
genes like me logo Genes that share ontologies with ZNHIT3: view

No data available for Pathways by source and SIGNOR curated interactions for ZNHIT3 Gene

Drugs & Compounds for ZNHIT3 Gene

No Compound Related Data Available

Transcripts for ZNHIT3 Gene

Unigene Clusters for ZNHIT3 Gene

Zinc finger, HIT-type containing 3:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNHIT3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNHIT3 Gene

No ASD Table

Relevant External Links for ZNHIT3 Gene

GeneLoc Exon Structure for
ZNHIT3
ECgene alternative splicing isoforms for
ZNHIT3

Expression for ZNHIT3 Gene

mRNA expression in normal human tissues for ZNHIT3 Gene

Protein differential expression in normal tissues from HIPED for ZNHIT3 Gene

This gene is overexpressed in Lung (50.3) and Bone marrow mesenchymal stem cell (18.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNHIT3 Gene



SOURCE GeneReport for Unigene cluster for ZNHIT3 Gene Hs.2210

genes like me logo Genes that share expression patterns with ZNHIT3: view

Protein tissue co-expression partners for ZNHIT3 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNHIT3 Gene

Orthologs for ZNHIT3 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNHIT3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ZNHIT3 35
  • 85.28 (n)
  • 85.06 (a)
dog
(Canis familiaris)
Mammalia ZNHIT3 35
  • 87.1 (n)
  • 87.74 (a)
mouse
(Mus musculus)
Mammalia Znhit3 35
  • 81.9 (n)
  • 80.79 (a)
Znhit3 16
chimpanzee
(Pan troglodytes)
Mammalia ZNHIT3 35
  • 99.35 (n)
  • 99.35 (a)
rat
(Rattus norvegicus)
Mammalia Znhit3 35
  • 82.43 (n)
  • 80.41 (a)
chicken
(Gallus gallus)
Aves ZNHIT3 35
  • 61.2 (n)
  • 56.25 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia znhit3 35
  • 56.72 (n)
  • 50 (a)
zebrafish
(Danio rerio)
Actinopterygii znhit3 35
  • 56.79 (n)
  • 54.07 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011858 35
  • 51.63 (n)
  • 45.11 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG8204 35
  • 47.95 (n)
  • 43.08 (a)
Species with no ortholog for ZNHIT3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNHIT3 Gene

ENSEMBL:
Gene Tree for ZNHIT3 (if available)
TreeFam:
Gene Tree for ZNHIT3 (if available)

Paralogs for ZNHIT3 Gene

genes like me logo Genes that share paralogs with ZNHIT3: view

No data available for Paralogs for ZNHIT3 Gene

Variants for ZNHIT3 Gene

Sequence variations from dbSNP and Humsavar for ZNHIT3 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs58108691 -- 36,489,638(+) TTTTT(-/T/TT)CTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNHIT3 Gene

Variant ID Type Subtype PubMed ID
nsv428340 CNV Gain 18775914
dgv946e1 CNV Complex 17122850
dgv948e1 CNV Complex 17122850
dgv122e55 CNV Gain 17911159
esv2751645 CNV Gain 17911159
nsv526727 CNV Gain 19592680
nsv469796 CNV Gain 16826518
nsv471697 CNV Gain 15918152
essv6619 CNV CNV 17122850
nsv469853 CNV Complex 16826518
nsv457734 CNV Gain 19166990
nsv516100 CNV Gain+Loss 19592680

Variation tolerance for ZNHIT3 Gene

Residual Variation Intolerance Score: 34.21% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.74; 15.67% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNHIT3 Gene

HapMap Linkage Disequilibrium report
ZNHIT3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNHIT3 Gene

Disorders for ZNHIT3 Gene

Relevant External Links for ZNHIT3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNHIT3
genes like me logo Genes that share disorders with ZNHIT3: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNHIT3 Gene

Publications for ZNHIT3 Gene

  1. Truncated RIP3 (tRIP3) acts upstream of FADD to induce apoptosis in the human hepatocellular carcinoma cell line QGY-7703. (PMID: 16844082) Feng S. … Wu M. (Biochem. Biophys. Res. Commun. 2006) 23 67
  2. Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor. (PMID: 7776974) Lee J.W. … Moore D.D. (Mol. Endocrinol. 1995) 2 67
  3. [Molecular biology and laboratory diagnosis of hypothalamic-pituitary-thyroid axis]. (PMID: 1779466) Miyai K. (Rinsho Byori 1991) 23 67
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  5. Protein Hit1, a novel box C/D snoRNP assembly factor, controls cellular concentration of the scaffolding protein Rsa1 by direct interaction. (PMID: 25170085) RothAc B. … Charpentier B. (Nucleic Acids Res. 2014) 67

Products for ZNHIT3 Gene

Sources for ZNHIT3 Gene

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