ZNHIT2 Gene
protein-coding GIFtS: 41
GCID: GC11M064883
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zinc finger, HIT-type containing 2(Previous names: chromosome 11 open reading frame 5, zinc finger, HIT domain...)
(Previous symbol: C11orf5)
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Aliases
for ZNHIT2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger, HIT-Type Containing 21 2 | | Chromosome 11 Open Reading Frame 51 | | C11orf51 2 3 5 | | Zinc Finger HIT Domain-Containing Protein 22 | | FON1 2 5 | | Zinc Finger, HIT Type 22 | | Zinc Finger, HIT Domain Containing 21 2 | | Protein FON3 |
Export aliases for ZNHIT2 gene to outside databasesPrevious GC identifers: GC11M064640 GC11M061210 |
Summaries
for ZNHIT2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for ZNHIT2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_167190.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZNHIT2 gene promoter:
HEN1 GR AP-1 GR-beta GR-alpha ATF ATF6
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZNHIT2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNHIT2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11q13 Ensembl cytogenetic band: 11q13.1 HGNC cytogenetic band: 11q13ZNHIT2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11M064883: view genomic region
(about GC identifiers)
Start:
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64,883,875 bp from pter |
End:
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64,885,170 bp from pter |
Size:
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1,296 bases |
Orientation:
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minus strand |
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Proteins
for ZNHIT2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZNHI2_HUMAN, Q9UHR6 (See
protein sequence)Recommended Name: Zinc finger HIT domain-containing protein 2 Size: 403 amino acids; 42884 Da
1 PDB 3D structure from  and Proteopedia  for ZNHIT2:1X4S (3D)
Secondary accessions: Q3SY14 Q8IUV0Explore the universe of human proteins at neXtProt for ZNHIT2: NX_Q9UHR6
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9UHR6
ZNHIT2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_055020.1
ENSEMBL proteins: ENSP00000436896 ENSP00000308548
Human Recombinant Protein Products:
ZNHIT2 Antibody Products:
Assay Products for ZNHIT2: |
Protein
Domains /
Families
for ZNHIT2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZNHIT2 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9UHR6ProtoNet protein and cluster: Q9UHR6 1 Blocks protein family: IPB007529 HIT Zn-finger
UniProtKB/Swiss-Prot: ZNHI2_HUMAN, Q9UHR6Similarity: Contains 1 HIT-type zinc finger |
Function
for ZNHIT2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNHIT2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNHIT2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: ZNHIT2 (NM_014205) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNHIT2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNHIT2 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0046872 | metal ion binding |
IEA | -- |
ZNHIT2 for ontologies About GeneDecksing
|
Pathways & Interactions
for ZNHIT2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNHIT2
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
2 Interacting proteins for ZNHIT2 (Q9UHR63 ENSP000003085484) via UniProtKB, MINT, STRING, and/or I2DAbout this table
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Drugs & Compounds
for ZNHIT2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZNHIT2
Search CenterWatch for drugs/clinical trials and news about ZNHIT2 / ZNHI2
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Transcripts
for ZNHIT2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZNHIT2 gene: NM_014205.2 Unigene Cluster for ZNHIT2: Zinc finger, HIT-type containing 2 Hs.121025 [show with all ESTs]Unigene Representative Sequence: AK0270812 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000528598 ENST00000310597(uc001ocw.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNHIT2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNHIT2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ZNHIT2 (NM_014205) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNHIT2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNHIT2 |
Additional cDNA sequence: AF119497.1 AK027081.1 AK223333.1 AK223358.1 BC029825.1 BC038089.1 BC052240.1 BC057799.1 BC104002.2 BC104003.2 3 DOTS entries: DT.100849242 DT.114951 DT.120731422 24/687 AceView cDNA sequences (see all 687): AI049653 BQ690084 AA378334 BU070969 BQ678659 BU944592 AI869263 CB151362 BQ019307 BQ899275 BE503262 BM455834 CF127455 AF119497 BQ877338 AA652228 AI796073 AK129795 AI862036 BQ878332 AI024415 BP378529 BM552327 AI760611
GeneLoc Exon Structure
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Expression
for ZNHIT2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZNHIT2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTGTGGTAGC
About this image
See ZNHIT2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZNHIT2
SOURCE GeneReport for Unigene cluster: Hs.121025
UniProtKB/Swiss-Prot: ZNHI2_HUMAN, Q9UHR6Tissue specificity: Low expression in most tissues; highly expressed in testis
SABiosciences Custom PCR Arrays for ZNHIT2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNHIT2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ZNHIT2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNHIT2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNHIT2 |
Orthologs
for ZNHIT2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for ZNHIT2 gene from 7/21 species (see all 21) About this table
ENSEMBL Gene Tree for ZNHIT2 (if available)
TreeFam Gene Tree for ZNHIT2 (if available) |
Paralogs
for ZNHIT2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for ZNHIT2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
| | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNHIT2 |
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Disorders
/ Diseases
for ZNHIT2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ZNHIT2 for disorders About GeneDecksing
OMIM gene information: 604575
OMIM disorders: --
2  diseases for ZNHIT2: About MalaCardschoriocarcinoma malaria
Export disorders for ZNHIT2 gene to outside databases
|
Publications
for ZNHIT2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZNHIT2 gene, integrated from 9 sources (see all 16):
(articles sorted by number of sources associating them with ZNHIT2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Molecular characterization of human and murine c11orf5, a new member of the FAUNA gene cluster. (PubMed id 10602999)1, 2 Lemmens I.H.... Kas K. (2000)
- Solution structure of the zinc finger HIT domain in protein FON. (PubMed id 17656577)1, 9 He F....Yokoyama S. (2007)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Global identification of modular cullin-RING ligase su bstrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (2011)
- Systematic analysis of human protein complexes identi fies chromosome segregation proteins. (PubMed id 20360068)1 Hutchins J.R....Peters J.M. (2010)
- Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. (PubMed id 18691976)2 Daub H.... Mann M. (2008)
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External Searches for ZNHIT2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing ZNHIT2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
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Other Databases showing ZNHIT2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZNHIT2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZNHIT2 | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for ZNHIT2 gene:
Search GeneIP for patents involving ZNHIT2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZNHIT2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ZNHIT2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZNHIT2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNHIT2 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ZNHIT2 | | OriGene 3'-UTR Clone for ZNHIT2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNHIT2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNHIT2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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 | | | ZNHIT2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | Search ThermoFisher Antibodies for ZNHIT2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNHIT2 |
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