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ZNHIT2 Gene

protein-coding   GIFtS: 49
GCID: GC11M064883

Zinc Finger, HIT-Type Containing 2

(Previous names: chromosome 11 open reading frame 5, zinc finger, HIT domain...)
(Previous symbol: C11orf5)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger, HIT-Type Containing 21 2     Chromosome 11 Open Reading Frame 51
C11orf51 2 3 5     Zinc Finger HIT Domain-Containing Protein 22
Zinc Finger, HIT Domain Containing 21 2     Zinc Finger, HIT Type 22
FON2 5     Protein FON3

External Ids:    HGNC: 11771   Entrez Gene: 7412   Ensembl: ENSG000001742767   OMIM: 6045755   UniProtKB: Q9UHR63   

Export aliases for ZNHIT2 gene to outside databases

Previous GC identifers: GC11M064640 GC11M061210


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZNHIT2 Gene:
ZNHIT2 (zinc finger, HIT-type containing 2) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NC_018922.2  NT_167190.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZNHIT2 gene promoter:
         HEN1   GR   AP-1   GR-beta   GR-alpha   ATF   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNHIT2 promoter sequence
   Search Chromatin IP Primers for ZNHIT2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNHIT2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13   Ensembl cytogenetic band:  11q13.1   HGNC cytogenetic band: 11q13

ZNHIT2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNHIT2 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M064883:  view genomic region     (about GC identifiers)

Start:
64,883,875 bp from pter      End:
64,885,170 bp from pter
Size:
1,296 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ZNHI2_HUMAN, Q9UHR6 (See protein sequence)
Recommended Name: Zinc finger HIT domain-containing protein 2  
Size: 403 amino acids; 42884 Da
1 PDB 3D structure from and Proteopedia for ZNHIT2:
1X4S (3D)    
Secondary accessions: Q3SY14 Q8IUV0

Explore the universe of human proteins at neXtProt for ZNHIT2: NX_Q9UHR6

Explore proteomics data for ZNHIT2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys303
  • Modification sites at PhosphoSitePlus

  • See ZNHIT2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_055020.1  
    ENSEMBL proteins: 
     ENSP00000436896   ENSP00000308548  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNHIT: Zinc fingers, HIT-type

    1 InterPro protein domain:
     IPR007529 Znf_HIT

    Graphical View of Domain Structure for InterPro Entry Q9UHR6

    ProtoNet protein and cluster: Q9UHR6

    1 Blocks protein domain: IPB007529 HIT Zn-finger

    UniProtKB/Swiss-Prot: ZNHI2_HUMAN, Q9UHR6
    Similarity: Contains 1 HIT-type zinc finger


    Find genes that share domains with ZNHIT2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with ZNHIT2           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ZNHIT2
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    miRNA
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    miRTarBase miRNAs that target ZNHIT2:
    hsa-mir-26b-5p (MIRT030125)

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNHIT2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    extracellular2
    nucleus2

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNHIT2
    Interactions:

        Search GeneGlobe Interaction Network for ZNHIT2

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for ZNHIT2 (Q9UHR63 ENSP000003085484) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RUVBL2Q9Y2303, ENSP000002214134I2D: score=1 STRING: ENSP00000221413
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZNHIT2 (ZNHI2)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ZNHIT2 gene: 
    NM_014205.2  

    Unigene Cluster for ZNHIT2:

    Zinc finger, HIT-type containing 2
    Hs.121025  [show with all ESTs]
    Unigene Representative Sequence: AK027081
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000528598 ENST00000310597(uc001ocw.3)
    miRNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ZNHIT2
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    Primer
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    OriGene qPCR primer pairs and template standards for ZNHIT2
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ZNHIT2
      QuantiTect SYBR Green Assays in human, mouse, rat ZNHIT2
      QuantiFast Probe-based Assays in human, mouse, rat ZNHIT2

    Additional mRNA sequence: 

    AF119497.1 AK027081.1 AK223333.1 AK223358.1 BC029825.1 BC038089.1 BC052240.1 BC057799.1 
    BC104002.2 BC104003.2 

    3 DOTS entries:

    DT.100849242  DT.114951  DT.120731422 

    Selected AceView cDNA sequences (see all 687):

    BU163109 AA211074 BU858215 AW005207 BQ130521 AI936858 CR600382 AW003124 
    AI205807 BU197059 AI472149 CF131311 BQ883122 BG250495 BQ681149 BQ691731 
    BM454522 CR598452 BU168456 BE049388 C00030 BX102551 BU632136 BE858727 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZNHIT2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGTGGTAGC
    ZNHIT2 Expression
    About this image

    ZNHIT2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZNHIT2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.121025

    UniProtKB/Swiss-Prot: ZNHI2_HUMAN, Q9UHR6
    Tissue specificity: Low expression in most tissues; highly expressed in testis

        Custom PCR Arrays for ZNHIT2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNHIT2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ZNHIT2 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Znhit21 , 5 zinc finger, HIT domain containing 2, pseudogene5
    zinc finger, HIT domain containing 21
    81.36(n)1
    83.38(a)1
      19 (4.34 cM)5
    298051  NM_013859.21  NP_038887.21 
     60611925 
    lizard
    (Anolis carolinensis)
    Reptilia ZNHIT26
    zinc finger, HIT-type containing 2
    40(a)
    1 ↔ 1
    GL344606.1(14107-16473)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia znhit21 zinc finger, HIT-type containing 2 45.42(n)
    42.42(a)
      448072  NM_001005625.1  NP_001005625.1 
    zebrafish
    (Danio rerio)
    Actinopterygii znhit21 zinc finger, HIT-type containing 2 45.96(n)
    38.46(a)
      777606  NM_001077618.1  NP_001071086.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG312231 CG31223   --   326127  NM_169932.2  NP_732563.1 
    worm
    (Caenorhabditis elegans)
    Secernentea zhit-26
    Protein ZHIT-2 (zhit-2) mRNA, complete cds
    26(a)
    1 ↔ 1
    III(4243669-4244385) WBGene00009648
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G638301 AT5G63830 39.76(n)
    30.55(a)
      836503  NM_125778.3  NP_201188.3 
    rice
    (Oryza sativa)
    Liliopsida Os10g05207001 Os10g0520700 44.44(n)
    35.06(a)
      4349140  NM_001071621.1  NP_001065086.1 


    ENSEMBL Gene Tree for ZNHIT2 (if available)
    TreeFam Gene Tree for ZNHIT2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZNHIT2 (see all 101)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0357204
    A breast cancer sample4--see VAR_0357202 A P mis40--------
    rs3751442011,2
    C--64803892(+) CTCGCC/TTGCTT 2 S G mis10--------
    rs359768141,2
    C,F--64803948(+) AGACTT/CGCTGG 2 /Q /R mis12Minor allele frequency- C:0.00NA 2534
    rs2005640111,2
    C--64803968(+) GCTCCG/AGAAAC 2 /S syn11Minor allele frequency- A:0.00EU 457
    rs1995555421,2
    --64804011(+) GCGCGA/TCGTCA 2 D V mis10--------
    rs2017604691,2
    --64804086(+) CGAGCA/GGCGAG 2 P L mis10--------
    rs2005080221,2
    --64804157(+) GCCCCC/GGGGAC 2 P syn10--------
    rs359849381,2
    C--64804178(+) ACCCGC/ATCGGC 2 /E /D mis11Minor allele frequency- A:0.01NA 74
    rs359832511,2,,4
    C,F--64804185(+) CGGCGG/ACCGCG 2 /A /V mis14Minor allele frequency- A:0.10NA WA 196
    rs351783031,2
    C,F--64804206(+) CGGAGG/TCATCT 2 D A mis12Minor allele frequency- T:0.00NA EU 499

    HapMap Linkage Disequilibrium report for ZNHIT2 (64883875 - 64885170 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for ZNHIT2:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv1174n71CNV Loss21882294
    nsv526181CNV Gain19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ZNHIT2
    DNA2.0 Custom Variant and Variant Library Synthesis for ZNHIT2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604575    OMIM disorders: --


    Find genes that share disorders with ZNHIT2           About GenesLikeMe


    Export disorders for ZNHIT2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZNHIT2 gene, integrated from 10 sources (see all 17):
    (articles sorted by number of sources associating them with ZNHIT2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    2. Molecular characterization of human and murine c11orf5, a new member of the FAUNA gene cluster. (PubMed id 10602999)1, 2 Lemmens I.H.... Kas K. (Mamm. Genome 2000)
    3. Solution structure of the zinc finger HIT domain in protein FON. (PubMed id 17656577)1, 9 He F....Yokoyama S. (Protein Sci. 2007)
    4. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    5. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    6. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    7. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    8. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    9. Global identification of modular cullin-RING ligase substrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (Cell 2011)
    10. Systematic analysis of human protein complexes identifies chromosome segregation proteins. (PubMed id 20360068)1 Hutchins J.R.... Peters J.M. (Science 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 741 HGNC: 1177 AceView: MRPL49 Ensembl:ENSG00000174276 euGenes: HUgn741
    ECgene: ZNHIT2 H-InvDB: ZNHIT2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZNHIT2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZNHIT2 gene:
    Search GeneIP for patents involving ZNHIT2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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