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Aliases for ZNHIT2 Gene

Aliases for ZNHIT2 Gene

  • Zinc Finger HIT-Type Containing 2 2 3 5
  • Zinc Finger, HIT Domain Containing 2 2 3
  • C11orf5 3 4
  • Zinc Finger HIT Domain-Containing Protein 2 3
  • Chromosome 11 Open Reading Frame 5 2
  • Zinc Finger, HIT Type 2 3
  • Protein FON 4
  • FON 3

External Ids for ZNHIT2 Gene

Previous HGNC Symbols for ZNHIT2 Gene

  • C11orf5

Previous GeneCards Identifiers for ZNHIT2 Gene

  • GC11M064640
  • GC11M064883
  • GC11M061210

Summaries for ZNHIT2 Gene

GeneCards Summary for ZNHIT2 Gene

ZNHIT2 (Zinc Finger HIT-Type Containing 2) is a Protein Coding gene. Diseases associated with ZNHIT2 include Triple-Receptor Negative Breast Cancer.

Additional gene information for ZNHIT2 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNHIT2 Gene

Genomics for ZNHIT2 Gene

Regulatory Elements for ZNHIT2 Gene

Enhancers for ZNHIT2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11H065470 2.7 VISTA FANTOM5 Ensembl ENCODE dbSUPER 33.2 -372.3 -372346 40 MLX ZFP64 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 SP3 MCM3 SF1 ZFPL1 POLA2 LOC105369352 SART1 PCNX3 EIF1AD KAT5 SF3B2 MUS81
GH11H065414 2.2 FANTOM5 Ensembl ENCODE dbSUPER 25.4 -306.4 -306444 18.8 MLX ZFP64 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 SP3 MEF2D SF1 LOC105369352 ZFPL1 KAT5 SART1 MUS81 EIF1AD PCNX3 POLA2 SF3B2
GH11H064331 1.6 Ensembl ENCODE dbSUPER 15.9 +785.8 785846 1.7 HDGF PKNOX1 ARNT ARID4B SIN3A YBX1 ZNF207 ZNF143 FOS MCM3 SF1 POLA2 PLCB3 ZFPL1 ENSG00000257086 FAU ATG2A ZNHIT2 NAALADL1 IMMP1LP1
GH11H065886 1.9 FANTOM5 ENCODE dbSUPER 11.2 -777.7 -777721 18.4 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC ZC3H11A MEF2D SNX32 RBM14 ENSG00000258297 ENSG00000254461 MUS81 SART1 CTSW KAT5 SF3B2 EIF1AD
GH11H065910 1.8 FANTOM5 ENCODE dbSUPER 11.2 -798.0 -797990 11.4 PKNOX1 MLX ARNT ZFP64 ARID4B SIN3A ZBTB7B YY1 ZNF766 CBX5 LOC105369352 RBM14 ZFPL1 ENSG00000254461 ENSG00000258297 MUS81 EIF1AD KAT5 DPF2 SF3B2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNHIT2 on UCSC Golden Path with GeneCards custom track

Promoters for ZNHIT2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000040779 238 1001 HDGF FOXA2 PKNOX1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ZNF207

Genomic Locations for ZNHIT2 Gene

Genomic Locations for ZNHIT2 Gene
chr11:65,116,403-65,117,738
(GRCh38/hg38)
Size:
1,336 bases
Orientation:
Minus strand
chr11:64,883,875-64,885,170
(GRCh37/hg19)

Genomic View for ZNHIT2 Gene

Genes around ZNHIT2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNHIT2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNHIT2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNHIT2 Gene

Proteins for ZNHIT2 Gene

  • Protein details for ZNHIT2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UHR6-ZNHI2_HUMAN
    Recommended name:
    Zinc finger HIT domain-containing protein 2
    Protein Accession:
    Q9UHR6
    Secondary Accessions:
    • Q3SY14
    • Q8IUV0

    Protein attributes for ZNHIT2 Gene

    Size:
    403 amino acids
    Molecular mass:
    42884 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for ZNHIT2 Gene

neXtProt entry for ZNHIT2 Gene

Post-translational modifications for ZNHIT2 Gene

  • Ubiquitination at Lys303
  • Modification sites at PhosphoSitePlus

Other Protein References for ZNHIT2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNHIT2 Gene

Domains & Families for ZNHIT2 Gene

Gene Families for ZNHIT2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ZNHIT2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for ZNHIT2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ZNHIT2: view

No data available for UniProtKB/Swiss-Prot for ZNHIT2 Gene

Function for ZNHIT2 Gene

Phenotypes From GWAS Catalog for ZNHIT2 Gene

Gene Ontology (GO) - Molecular Function for ZNHIT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNHIT2: view

Phenotypes for ZNHIT2 Gene

GenomeRNAi human phenotypes for ZNHIT2:
genes like me logo Genes that share phenotypes with ZNHIT2: view

Animal Model Products

CRISPR Products

miRNA for ZNHIT2 Gene

miRTarBase miRNAs that target ZNHIT2

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNHIT2 Gene

Localization for ZNHIT2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNHIT2 gene
Compartment Confidence
nucleus 3
cytosol 3
extracellular 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for ZNHIT2 Gene

Pathways & Interactions for ZNHIT2 Gene

SuperPathways for ZNHIT2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNHIT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0022008 neurogenesis IBA --
genes like me logo Genes that share ontologies with ZNHIT2: view

No data available for Pathways by source and SIGNOR curated interactions for ZNHIT2 Gene

Drugs & Compounds for ZNHIT2 Gene

No Compound Related Data Available

Transcripts for ZNHIT2 Gene

mRNA/cDNA for ZNHIT2 Gene

Unigene Clusters for ZNHIT2 Gene

Zinc finger, HIT-type containing 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNHIT2 Gene

No ASD Table

Relevant External Links for ZNHIT2 Gene

GeneLoc Exon Structure for
ZNHIT2
ECgene alternative splicing isoforms for
ZNHIT2

Expression for ZNHIT2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNHIT2 Gene

mRNA differential expression in normal tissues according to GTEx for ZNHIT2 Gene

This gene is overexpressed in Testis (x6.7).

Protein differential expression in normal tissues from HIPED for ZNHIT2 Gene

This gene is overexpressed in Testis (41.2) and Peripheral blood mononuclear cells (8.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZNHIT2 Gene



Protein tissue co-expression partners for ZNHIT2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNHIT2 Gene:

ZNHIT2

SOURCE GeneReport for Unigene cluster for ZNHIT2 Gene:

Hs.121025

mRNA Expression by UniProt/SwissProt for ZNHIT2 Gene:

Q9UHR6-ZNHI2_HUMAN
Tissue specificity: Low expression in most tissues; highly expressed in testis.

Evidence on tissue expression from TISSUES for ZNHIT2 Gene

  • Pancreas(4.1)
  • Nervous system(2.1)
genes like me logo Genes that share expression patterns with ZNHIT2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNHIT2 Gene

Orthologs for ZNHIT2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ZNHIT2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNHIT2 33 34
  • 99.42 (n)
cow
(Bos Taurus)
Mammalia ZNHIT2 33 34
  • 86.35 (n)
dog
(Canis familiaris)
Mammalia ZNHIT2 33 34
  • 85.61 (n)
mouse
(Mus musculus)
Mammalia Znhit2 33 16 34
  • 81.36 (n)
rat
(Rattus norvegicus)
Mammalia Znhit2 33
  • 80.82 (n)
oppossum
(Monodelphis domestica)
Mammalia ZNHIT2 34
  • 65 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZNHIT2 34
  • 40 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia znhit2 33
  • 45.42 (n)
zebrafish
(Danio rerio)
Actinopterygii znhit2 33 34
  • 45.96 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001270 33
  • 44.36 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG31223 33
worm
(Caenorhabditis elegans)
Secernentea zhit-2 34
  • 26 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G63830 33
  • 39.76 (n)
rice
(Oryza sativa)
Liliopsida Os10g0520700 33
  • 44.44 (n)
Species where no ortholog for ZNHIT2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZNHIT2 Gene

ENSEMBL:
Gene Tree for ZNHIT2 (if available)
TreeFam:
Gene Tree for ZNHIT2 (if available)

Paralogs for ZNHIT2 Gene

No data available for Paralogs for ZNHIT2 Gene

Variants for ZNHIT2 Gene

Sequence variations from dbSNP and Humsavar for ZNHIT2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
VAR_035720 A breast cancer sample
rs1001542660 -- 65,117,560(+) GCGCA(A/G)CGAGC reference, synonymous-codon
rs1002431275 -- 65,117,519(+) CGGTA(G/T)AAGTT reference, missense
rs1002573048 -- 65,118,280(+) ACTAA(C/G)AATAC upstream-variant-2KB
rs1002948993 -- 65,118,624(+) GGAGC(A/C)GGGGG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ZNHIT2 Gene

Variant ID Type Subtype PubMed ID
nsv526181 CNV gain 19592680

Variation tolerance for ZNHIT2 Gene

Residual Variation Intolerance Score: 76.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.18; 51.95% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNHIT2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNHIT2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNHIT2 Gene

Disorders for ZNHIT2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZNHIT2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
triple-receptor negative breast cancer
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ZNHIT2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNHIT2
genes like me logo Genes that share disorders with ZNHIT2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNHIT2 Gene

Publications for ZNHIT2 Gene

  1. Solution structure of the zinc finger HIT domain in protein FON. (PMID: 17656577) He F … Yokoyama S (Protein science : a publication of the Protein Society 2007) 3 22 60
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  3. Molecular characterization of human and murine C11orf5, a new member of the FAUNA gene cluster. (PMID: 10602999) Lemmens IH … Kas K (Mammalian genome : official journal of the International Mammalian Genome Society 2000) 3 4 60
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 60

Products for ZNHIT2 Gene

Sources for ZNHIT2 Gene

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