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Aliases for ZNHIT2 Gene

Aliases for ZNHIT2 Gene

  • Zinc Finger, HIT-Type Containing 2 2 3
  • C11orf5 3 4 6
  • Zinc Finger, HIT Domain Containing 2 2 3
  • FON 3 6
  • Zinc Finger HIT Domain-Containing Protein 2 3
  • Chromosome 11 Open Reading Frame 5 2
  • Zinc Finger, HIT Type 2 3
  • Protein FON 4

External Ids for ZNHIT2 Gene

Previous Symbols for ZNHIT2 Gene

  • C11orf5

Summaries for ZNHIT2 Gene

GeneCards Summary for ZNHIT2 Gene

ZNHIT2 (Zinc Finger, HIT-Type Containing 2) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNHIT2 Gene

Genomics for ZNHIT2 Gene

Genomic Location for ZNHIT2 Gene

65,116,403 bp from pter
65,117,708 bp from pter
1,306 bases
Minus strand

Genomic View for ZNHIT2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNHIT2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNHIT2 Gene

Regulatory Elements for ZNHIT2 Gene

Proteins for ZNHIT2 Gene

  • Protein details for ZNHIT2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger HIT domain-containing protein 2
    Protein Accession:
    Secondary Accessions:
    • Q3SY14
    • Q8IUV0

    Protein attributes for ZNHIT2 Gene

    403 amino acids
    Molecular mass:
    42884 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for ZNHIT2 Gene

neXtProt entry for ZNHIT2 Gene

Proteomics data for ZNHIT2 Gene at MOPED

Post-translational modifications for ZNHIT2 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys303

Other Protein References for ZNHIT2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNHIT2 Gene

Domains for ZNHIT2 Gene

Gene Families for ZNHIT2 Gene

  • ZNHIT :Zinc fingers, HIT-type

Protein Domains for ZNHIT2 Gene



  • Contains 1 HIT-type zinc finger.:
    • Q9UHR6
genes like me logo Genes that share domains with ZNHIT2: view

Function for ZNHIT2 Gene

Gene Ontology (GO) - Molecular Function for ZNHIT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNHIT2: view

miRNA for ZNHIT2 Gene

miRTarBase miRNAs that target ZNHIT2

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for ZNHIT2 Gene

Localization for ZNHIT2 Gene

Subcellular locations from

Jensen Localization Image for ZNHIT2 Gene COMPARTMENTS Subcellular localization image for ZNHIT2 gene
Compartment Confidence
cytosol 2
extracellular 2
nucleus 2

No data available for Gene Ontology (GO) - Cellular Components for ZNHIT2 Gene

Pathways for ZNHIT2 Gene

SuperPathways for ZNHIT2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNHIT2 Gene


No data available for Pathways by source for ZNHIT2 Gene

Transcripts for ZNHIT2 Gene

mRNA/cDNA for ZNHIT2 Gene

Unigene Clusters for ZNHIT2 Gene

Zinc finger, HIT-type containing 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNHIT2 Gene

No ASD Table

Relevant External Links for ZNHIT2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNHIT2 Gene

mRNA expression in normal human tissues for ZNHIT2 Gene

mRNA differential expression in normal tissues according to GTEx for ZNHIT2 Gene

This gene is overexpressed in Testis (6.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZNHIT2 Gene

SOURCE GeneReport for Unigene cluster for ZNHIT2 Gene Hs.121025

mRNA Expression by UniProt/SwissProt for ZNHIT2 Gene

Tissue specificity: Low expression in most tissues; highly expressed in testis.
genes like me logo Genes that share expressions with ZNHIT2: view

Orthologs for ZNHIT2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ZNHIT2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNHIT2 36
  • 99.42 (n)
  • 98.76 (a)
  • 99 (a)
(Bos Taurus)
Mammalia ZNHIT2 36
  • 86.35 (n)
  • 86.68 (a)
  • 86 (a)
(Canis familiaris)
Mammalia ZNHIT2 36
  • 85.61 (n)
  • 83.08 (a)
  • 83 (a)
(Mus musculus)
Mammalia Znhit2 36
  • 81.36 (n)
  • 83.38 (a)
Znhit2 16
Znhit2 37
  • 82 (a)
(Monodelphis domestica)
Mammalia ZNHIT2 37
  • 65 (a)
(Rattus norvegicus)
Mammalia Znhit2 36
  • 80.82 (n)
  • 81.91 (a)
(Anolis carolinensis)
Reptilia ZNHIT2 37
  • 40 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia znhit2 36
  • 45.42 (n)
  • 42.42 (a)
(Danio rerio)
Actinopterygii znhit2 36
  • 45.96 (n)
  • 38.46 (a)
znhit2 37
  • 25 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001270 36
  • 44.36 (n)
  • 31.29 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG31223 36
(Caenorhabditis elegans)
Secernentea zhit-2 37
  • 26 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G63830 36
  • 39.76 (n)
  • 30.55 (a)
(Oryza sativa)
Liliopsida Os10g0520700 36
  • 44.44 (n)
  • 35.06 (a)
Species with no ortholog for ZNHIT2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZNHIT2 Gene

Gene Tree for ZNHIT2 (if available)
Gene Tree for ZNHIT2 (if available)

Paralogs for ZNHIT2 Gene

No data available for Paralogs for ZNHIT2 Gene

Variants for ZNHIT2 Gene

Sequence variations from dbSNP and Humsavar for ZNHIT2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs1211975 -- 65,118,052(-) CCCAG(A/G)GTAGG upstream-variant-2KB
rs7925221 -- 65,118,643(+) CTAAT(A/G)GAGCT upstream-variant-2KB
rs7928262 -- 65,118,657(+) TCTTG(A/T)GGTGG upstream-variant-2KB
rs10501396 -- 65,117,973(+) CGTGG(A/C)CCGAT upstream-variant-2KB
rs11556920 - 65,117,191(+) GAGCT(C/T)CAGCT missense, reference

Structural Variations from Database of Genomic Variants (DGV) for ZNHIT2 Gene

Variant ID Type Subtype PubMed ID
nsv526181 CNV Gain 19592680
dgv1174n71 CNV Loss 21882294

Relevant External Links for ZNHIT2 Gene

HapMap Linkage Disequilibrium report

Disorders for ZNHIT2 Gene

No disorders were found for ZNHIT2 Gene.

No data available for UniProtKB/Swiss-Prot for ZNHIT2 Gene

Publications for ZNHIT2 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. Solution structure of the zinc finger HIT domain in protein FON. (PMID: 17656577) He F. … Yokoyama S. (Protein Sci. 2007) 3 23
  3. Molecular characterization of human and murine c11orf5, a new member of the FAUNA gene cluster. (PMID: 10602999) Lemmens I.H. … Kas K. (Mamm. Genome 2000) 3 4
  4. Characterization of five novel human genes in the 11q13-q22 region. (PMID: 10873569) O'Brien K.P. … Dumanski J.P. (Biochem. Biophys. Res. Commun. 2000) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for ZNHIT2 Gene

  • antibodies-online proteins for ZNHIT2
  • antibodies-online antibodies for ZNHIT2
  • antibodies-online kits for ZNHIT2

Sources for ZNHIT2 Gene

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