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Aliases for ZNHIT2 Gene

Aliases for ZNHIT2 Gene

  • Zinc Finger HIT-Type Containing 2 2 3
  • Zinc Finger, HIT Domain Containing 2 2 3
  • Zinc Finger, HIT-Type Containing 2 3 5
  • C11orf5 3 4
  • Chromosome 11 Open Reading Frame 5 2
  • Zinc Finger, HIT Type 2 3
  • Protein FON 4
  • FON 3

External Ids for ZNHIT2 Gene

Previous HGNC Symbols for ZNHIT2 Gene

  • C11orf5

Previous GeneCards Identifiers for ZNHIT2 Gene

  • GC11M064640
  • GC11M064883
  • GC11M061210

Summaries for ZNHIT2 Gene

GeneCards Summary for ZNHIT2 Gene

ZNHIT2 (Zinc Finger HIT-Type Containing 2) is a Protein Coding gene. Diseases associated with ZNHIT2 include Triple-Receptor Negative Breast Cancer.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNHIT2 Gene

Genomics for ZNHIT2 Gene

Regulatory Elements for ZNHIT2 Gene

Enhancers for ZNHIT2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZNHIT2 on UCSC Golden Path with GeneCards custom track

Promoters for ZNHIT2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNHIT2 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNHIT2 Gene

65,116,403 bp from pter
65,117,738 bp from pter
1,336 bases
Minus strand

Genomic View for ZNHIT2 Gene

Genes around ZNHIT2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNHIT2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNHIT2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNHIT2 Gene

Proteins for ZNHIT2 Gene

  • Protein details for ZNHIT2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger HIT domain-containing protein 2
    Protein Accession:
    Secondary Accessions:
    • Q3SY14
    • Q8IUV0

    Protein attributes for ZNHIT2 Gene

    403 amino acids
    Molecular mass:
    42884 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for ZNHIT2 Gene

neXtProt entry for ZNHIT2 Gene

Proteomics data for ZNHIT2 Gene at MOPED

Post-translational modifications for ZNHIT2 Gene

  • Ubiquitination at Lys 303
  • Modification sites at PhosphoSitePlus

Other Protein References for ZNHIT2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNHIT2 Gene

Domains & Families for ZNHIT2 Gene

Gene Families for ZNHIT2 Gene

Protein Domains for ZNHIT2 Gene


Suggested Antigen Peptide Sequences for ZNHIT2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 HIT-type zinc finger.
  • Contains 1 HIT-type zinc finger.
genes like me logo Genes that share domains with ZNHIT2: view

Function for ZNHIT2 Gene

Phenotypes for ZNHIT2 Gene

GenomeRNAi human phenotypes for ZNHIT2:
genes like me logo Genes that share phenotypes with ZNHIT2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for ZNHIT2

miRNA for ZNHIT2 Gene

miRTarBase miRNAs that target ZNHIT2

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNHIT2 Gene

Localization for ZNHIT2 Gene

Subcellular locations from

Jensen Localization Image for ZNHIT2 Gene COMPARTMENTS Subcellular localization image for ZNHIT2 gene
Compartment Confidence
cytosol 3
nucleus 3
extracellular 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ZNHIT2 Gene

Pathways & Interactions for ZNHIT2 Gene

SuperPathways for ZNHIT2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNHIT2 Gene


No data available for Pathways by source and SIGNOR curated interactions for ZNHIT2 Gene

Drugs & Compounds for ZNHIT2 Gene

No Compound Related Data Available

Transcripts for ZNHIT2 Gene

mRNA/cDNA for ZNHIT2 Gene

Unigene Clusters for ZNHIT2 Gene

Zinc finger, HIT-type containing 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNHIT2 Gene

No ASD Table

Relevant External Links for ZNHIT2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNHIT2 Gene

mRNA expression in normal human tissues for ZNHIT2 Gene

mRNA differential expression in normal tissues according to GTEx for ZNHIT2 Gene

This gene is overexpressed in Testis (x6.7).

Protein differential expression in normal tissues from HIPED for ZNHIT2 Gene

This gene is overexpressed in Testis (41.2) and Peripheral blood mononuclear cells (8.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZNHIT2 Gene

SOURCE GeneReport for Unigene cluster for ZNHIT2 Gene Hs.121025

mRNA Expression by UniProt/SwissProt for ZNHIT2 Gene

Tissue specificity: Low expression in most tissues; highly expressed in testis.
genes like me logo Genes that share expression patterns with ZNHIT2: view

Protein tissue co-expression partners for ZNHIT2 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for ZNHIT2 Gene

Orthologs for ZNHIT2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ZNHIT2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ZNHIT2 35
  • 86.35 (n)
  • 86.68 (a)
  • 86 (a)
(Canis familiaris)
Mammalia ZNHIT2 35
  • 85.61 (n)
  • 83.08 (a)
  • 83 (a)
(Mus musculus)
Mammalia Znhit2 35
  • 81.36 (n)
  • 83.38 (a)
Znhit2 16
Znhit2 36
  • 82 (a)
(Pan troglodytes)
Mammalia ZNHIT2 35
  • 99.42 (n)
  • 98.76 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Znhit2 35
  • 80.82 (n)
  • 81.91 (a)
(Monodelphis domestica)
Mammalia ZNHIT2 36
  • 65 (a)
(Anolis carolinensis)
Reptilia ZNHIT2 36
  • 40 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia znhit2 35
  • 45.42 (n)
  • 42.42 (a)
(Danio rerio)
Actinopterygii znhit2 35
  • 45.96 (n)
  • 38.46 (a)
znhit2 36
  • 25 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001270 35
  • 44.36 (n)
  • 31.29 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG31223 35
(Caenorhabditis elegans)
Secernentea zhit-2 36
  • 26 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G63830 35
  • 39.76 (n)
  • 30.55 (a)
(Oryza sativa)
Liliopsida Os10g0520700 35
  • 44.44 (n)
  • 35.06 (a)
Species with no ortholog for ZNHIT2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZNHIT2 Gene

Gene Tree for ZNHIT2 (if available)
Gene Tree for ZNHIT2 (if available)

Paralogs for ZNHIT2 Gene

No data available for Paralogs for ZNHIT2 Gene

Variants for ZNHIT2 Gene

Sequence variations from dbSNP and Humsavar for ZNHIT2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
VAR_035720 A breast cancer sample
rs11556920 - 65,117,191(+) GAGCT(C/T)CAGCT reference, missense
rs35983251 - 65,117,127(+) CGGCG(A/G)CCGCG reference, missense
rs1211975 -- 65,118,052(-) CCCAG(A/G)GTAGG upstream-variant-2KB
rs61736618 -- 65,117,387(+) GCCGG(A/C/G)CCGGA reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for ZNHIT2 Gene

Variant ID Type Subtype PubMed ID
nsv526181 CNV Gain 19592680
dgv1174n71 CNV Loss 21882294

Variation tolerance for ZNHIT2 Gene

Residual Variation Intolerance Score: 76.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.18; 51.95% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ZNHIT2 Gene

Disorders for ZNHIT2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZNHIT2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
triple-receptor negative breast cancer
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ZNHIT2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with ZNHIT2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNHIT2 Gene

Publications for ZNHIT2 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. Solution structure of the zinc finger HIT domain in protein FON. (PMID: 17656577) He F. … Yokoyama S. (Protein Sci. 2007) 3 23
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  5. Kelch Domain of Gigaxonin Interacts with Intermediate Filament Proteins Affected in Giant Axonal Neuropathy. (PMID: 26460568) Johnson-Kerner B.L. … Wichterle H. (PLoS ONE 2015) 3

Products for ZNHIT2 Gene

Sources for ZNHIT2 Gene