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Aliases for ZNHIT1 Gene

Aliases for ZNHIT1 Gene

  • Zinc Finger, HIT-Type Containing 1 2 3
  • Zinc Finger Protein, Subfamily 4A (HIT Domain Containing), Member 1 2 3
  • Zinc Finger Protein Subfamily 4A Member 1 3 4
  • Putative Cyclin G1 Interacting Protein 2 3
  • Zinc Finger, HIT Domain Containing 1 2 3
  • Cyclin-G1-Binding Protein 1 3 4
  • P18 Hamlet 3 4
  • ZNFN4A1 3 4
  • Zinc Finger HIT Domain-Containing Protein 1 3
  • Zinc Finger, HIT Type 1 3
  • H_DJ0747G18.14 3
  • P18Hamlet 3
  • CGBP1 4
  • CG1I 3

External Ids for ZNHIT1 Gene

Previous HGNC Symbols for ZNHIT1 Gene

  • ZNFN4A1

Previous GeneCards Identifiers for ZNHIT1 Gene

  • GC07P100407
  • GC07P100421
  • GC07P100454
  • GC07P100647
  • GC07P100860
  • GC07P095454

Summaries for ZNHIT1 Gene

GeneCards Summary for ZNHIT1 Gene

ZNHIT1 (Zinc Finger, HIT-Type Containing 1) is a Protein Coding gene. GO annotations related to this gene include chromatin binding and histone deacetylase binding.

UniProtKB/Swiss-Prot for ZNHIT1 Gene

  • Seems to play a role in p53-mediated apoptosis induction. Binds to NR1D2 and relieves it of its inhibitory effect on the transcription of APOC3 without affecting its DNA-binding activity.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNHIT1 Gene

Genomics for ZNHIT1 Gene

Regulatory Elements for ZNHIT1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ZNHIT1 Gene

101,217,668 bp from pter
101,224,190 bp from pter
6,523 bases
Plus strand

Genomic View for ZNHIT1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNHIT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNHIT1 Gene

Proteins for ZNHIT1 Gene

  • Protein details for ZNHIT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger HIT domain-containing protein 1
    Protein Accession:
    Secondary Accessions:
    • Q6IB12

    Protein attributes for ZNHIT1 Gene

    154 amino acids
    Molecular mass:
    17536 Da
    Quaternary structure:
    • Interacts with MAPK11 and MAPK14. Component of the chromatin-remodeling SRCAP complex composed of at least SRCAP, DMAP1, RUVBL1, RUVBL2, ACTL6A, YEATS4, ACTR6 and ZNHIT1. Interacts with NR1D1 and NR2D2.

neXtProt entry for ZNHIT1 Gene

Proteomics data for ZNHIT1 Gene at MOPED

Post-translational modifications for ZNHIT1 Gene

Other Protein References for ZNHIT1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNHIT1 Gene

Domains for ZNHIT1 Gene

Gene Families for ZNHIT1 Gene

  • ZNHIT :Zinc fingers, HIT-type

Protein Domains for ZNHIT1 Gene


Suggested Antigen Peptide Sequences for ZNHIT1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • O43257
  • Belongs to the ZNHIT1 family.
  • Contains 1 HIT-type zinc finger.
genes like me logo Genes that share domains with ZNHIT1: view

Function for ZNHIT1 Gene

Molecular function for ZNHIT1 Gene

UniProtKB/Swiss-Prot Function: Seems to play a role in p53-mediated apoptosis induction. Binds to NR1D2 and relieves it of its inhibitory effect on the transcription of APOC3 without affecting its DNA-binding activity.
UniProtKB/Swiss-Prot Induction: Induced by DNA damage.

Gene Ontology (GO) - Molecular Function for ZNHIT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding --
GO:0005515 protein binding IPI 15647280
GO:0031491 nucleosome binding IBA --
GO:0042826 histone deacetylase binding IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNHIT1: view

Animal Model Products

CRISPR Products

miRNA for ZNHIT1 Gene

miRTarBase miRNAs that target ZNHIT1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNHIT1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for ZNHIT1 Gene

Localization for ZNHIT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNHIT1 Gene

Subcellular locations from

Jensen Localization Image for ZNHIT1 Gene COMPARTMENTS Subcellular localization image for ZNHIT1 gene
Compartment Confidence
nucleus 3
cytosol 2
extracellular 1

Gene Ontology (GO) - Cellular Components for ZNHIT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000812 Swr1 complex IBA --
GO:0005634 nucleus IDA 17892483
genes like me logo Genes that share ontologies with ZNHIT1: view

Pathways for ZNHIT1 Gene

SuperPathways for ZNHIT1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNHIT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0031063 regulation of histone deacetylation IBA --
GO:0042129 regulation of T cell proliferation IEA --
GO:0043486 histone exchange IBA --
GO:0070317 negative regulation of G0 to G1 transition IEA --
genes like me logo Genes that share ontologies with ZNHIT1: view

No data available for Pathways by source for ZNHIT1 Gene

Transcripts for ZNHIT1 Gene

mRNA/cDNA for ZNHIT1 Gene

Unigene Clusters for ZNHIT1 Gene

Zinc finger, HIT-type containing 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNHIT1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNHIT1 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b
SP1: - - - - - -
SP2: - - - -
SP3: - - - -
SP4: - - - - - - - -
SP5: - - - -
SP6: - - -

Relevant External Links for ZNHIT1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNHIT1 Gene

mRNA expression in normal human tissues for ZNHIT1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZNHIT1 Gene

SOURCE GeneReport for Unigene cluster for ZNHIT1 Gene Hs.211079

mRNA Expression by UniProt/SwissProt for ZNHIT1 Gene

Tissue specificity: Expressed abundantly in liver, but weakly in skeletal muscle, ovary and small intestine.
genes like me logo Genes that share expressions with ZNHIT1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for ZNHIT1 Gene

Orthologs for ZNHIT1 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNHIT1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNHIT1 35
  • 99.35 (n)
  • 100 (a)
  • 100 (a)
(Bos Taurus)
Mammalia ZNHIT1 35
  • 93.29 (n)
  • 100 (a)
  • 100 (a)
(Canis familiaris)
Mammalia ZNHIT1 35
  • 91.99 (n)
  • 100 (a)
  • 77 (a)
(Mus musculus)
Mammalia Znhit1 35
  • 88.66 (n)
  • 98.64 (a)
Znhit1 16
Znhit1 36
  • 95 (a)
(Monodelphis domestica)
Mammalia ZNHIT1 36
  • 98 (a)
(Ornithorhynchus anatinus)
Mammalia ZNHIT1 36
  • 54 (a)
(Rattus norvegicus)
Mammalia Znhit1 35
  • 87.53 (n)
  • 98.64 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.6977 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.1370 35
znhit1 35
  • 75.38 (n)
  • 83.01 (a)
(Danio rerio)
Actinopterygii Dr.16573 35
znhit1 35
  • 72.51 (n)
  • 79.87 (a)
znhit1 36
  • 79 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007853 35
  • 56.08 (n)
  • 52.03 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG31917 35
  • 57.76 (n)
  • 56.16 (a)
CG31917 36
  • 50 (a)
(Caenorhabditis elegans)
Secernentea zhit-1 35
  • 46.71 (n)
  • 42.18 (a)
zhit-1 36
  • 34 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 53 (a)
Species with no ortholog for ZNHIT1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZNHIT1 Gene

Gene Tree for ZNHIT1 (if available)
Gene Tree for ZNHIT1 (if available)

Paralogs for ZNHIT1 Gene Pseudogenes for ZNHIT1 Gene

genes like me logo Genes that share paralogs with ZNHIT1: view

No data available for Paralogs for ZNHIT1 Gene

Variants for ZNHIT1 Gene

Sequence variations from dbSNP and Humsavar for ZNHIT1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs12410 -- 101,224,014(+) GAAAG(A/C/G/T)CAGAA utr-variant-3-prime
rs14179 -- 101,223,747(+) CCCTT(C/T)TGTGC reference, synonymous-codon
rs1044491 -- 101,224,094(+) TGTGT(C/T)TTATC utr-variant-3-prime
rs1044500 -- 101,224,099(+) CTTAT(C/T)TGCCA utr-variant-3-prime
rs1044511 -- 101,224,135(+) ACTGT(C/T)TGGCA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ZNHIT1 Gene

Variant ID Type Subtype PubMed ID
esv2734888 CNV Deletion 23290073
nsv831075 CNV Loss 17160897
esv2422376 CNV Duplication 17116639
dgv7409n71 CNV Loss 21882294
esv2752134 CNV Gain 17911159
nsv831076 CNV Loss 17160897
dgv7410n71 CNV Loss 21882294
esv2422326 CNV Duplication 17116639

Relevant External Links for ZNHIT1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNHIT1 Gene

Disorders for ZNHIT1 Gene

No disorders were found for ZNHIT1 Gene.

No data available for UniProtKB/Swiss-Prot for ZNHIT1 Gene

Publications for ZNHIT1 Gene

  1. A zinc finger HIT domain-containing protein, ZNHIT-1, interacts with orphan nuclear hormone receptor Rev-erbbeta and removes Rev-erbbeta-induced inhibition of apoCIII transcription. (PMID: 17892483) Wang J. … Lu H. (FEBS J. 2007) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. The mammalian YL1 protein is a shared subunit of the TRRAP/TIP60 histone acetyltransferase and SRCAP complexes. (PMID: 15647280) Cai Y. … Conaway J.W. (J. Biol. Chem. 2005) 3 4
  4. A new p38 MAP kinase-regulated transcriptional coactivator that stimulates p53-dependent apoptosis. (PMID: 17380123) Cuadrado A. … Nebreda A.R. (EMBO J. 2007) 3 4
  5. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier L.W. … Wilson R.K. (Nature 2003) 3 4

Products for ZNHIT1 Gene

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