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ZNHIT1 Gene

protein-coding   GIFtS: 49
GCID: GC07P100860

Zinc Finger, HIT-Type Containing 1

(Previous names: zinc finger protein, subfamily 4A (HIT domain containing),...)
(Previous symbol: ZNFN4A1)
  Search for ZNHIT1
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Zinc Finger, HIT-Type Containing 11 2     P18 Hamlet2 3
ZNFN4A11 2 3     CG1I2
Zinc Finger Protein, Subfamily 4A (HIT Domain Containing), Member 11 2     H_DJ0747G18.142
Zinc Finger, HIT Domain Containing 11 2     p18Hamlet2
Putative Cyclin G1 Interacting Protein1 2     Zinc Finger HIT Domain-Containing Protein 12
Cyclin-G1-Binding Protein 12 3     Zinc Finger, HIT Type 12
Zinc Finger Protein Subfamily 4A Member 12 3     CGBP13

External Ids:    HGNC: 216881   Entrez Gene: 104672   Ensembl: ENSG000001064007   UniProtKB: O432573   
ORGUL members:         

Export aliases for ZNHIT1 gene to outside databases

Previous GC identifers: GC07P100407 GC07P100421 GC07P100454 GC07P100647 GC07P095454


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZNHIT1 Gene:
ZNHIT1 (zinc finger, HIT-type containing 1) is a protein-coding gene. GO annotations related to this gene include histone deacetylase binding and chromatin binding.

UniProtKB/Swiss-Prot: ZNHI1_HUMAN, O43257
Function: Seems to play a role in p53-mediated apoptosis induction. Binds to NR1D2 and relieves it of its
inhibitory effect on the transcription of APOC3 without affecting its DNA-binding activity




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000007.13  NC_018918.2  NT_007933.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZNHIT1 gene promoter:
         p53   HTF   Olf-1   HNF-4alpha2   NF-kappaB   FOXL1   HNF-4alpha1   NF-kappaB2   Pax-4a   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): ZNHIT1 promoter sequence
   Search Chromatin IP Primers for ZNHIT1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNHIT1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q22.1   Ensembl cytogenetic band:  7q22.1   HGNC cytogenetic band: 7q22.1

ZNHIT1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNHIT1 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P100860:  view genomic region     (about GC identifiers)

Start:
100,860,949 bp from pter      End:
100,867,471 bp from pter
Size:
6,523 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 100,219,372-100,225,858     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ZNHI1_HUMAN, O43257 (See protein sequence)
Recommended Name: Zinc finger HIT domain-containing protein 1  
Size: 154 amino acids; 17536 Da
Subunit: Interacts with MAPK11 and MAPK14. Component of the chromatin-remodeling SRCAP complex composed of at
least SRCAP, DMAP1, RUVBL1, RUVBL2, ACTL6A, YEATS4, ACTR6 and ZNHIT1. Interacts with NR1D1 and NR2D2
Secondary accessions: Q6IB12

Explore the universe of human proteins at neXtProt for ZNHIT1: NX_O43257

Explore proteomics data for ZNHIT1 at MOPED

Post-translational modifications: 

  • Phosphorylated on Thr by MAPK11 or MAPK141
  • Stres-induced ZNHIT1 is mainly regulated at the level of protein1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ZNHIT1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006340.1  
    ENSEMBL proteins: 
     ENSP00000304593  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNHIT: Zinc fingers, HIT-type

    1 InterPro protein domain:
     IPR007529 Znf_HIT

    Graphical View of Domain Structure for InterPro Entry O43257

    ProtoNet protein and cluster: O43257

    UniProtKB/Swiss-Prot: ZNHI1_HUMAN, O43257
    Similarity: Belongs to the ZNHIT1 family
    Similarity: Contains 1 HIT-type zinc finger


    Find genes that share domains with ZNHIT1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZNHI1_HUMAN, O43257
    Function: Seems to play a role in p53-mediated apoptosis induction. Binds to NR1D2 and relieves it of its
    inhibitory effect on the transcription of APOC3 without affecting its DNA-binding activity
    Induction: Induced by DNA damage

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003682chromatin binding IEA--
    GO:0005515protein binding IPI15647280
    GO:0042826histone deacetylase binding IEA--
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with ZNHIT1           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ZNHIT1
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    miRNA
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    miRTarBase miRNAs that target ZNHIT1:
    hsa-mir-26b-5p (MIRT029663)

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZNHI1_HUMAN, O43257: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol2
    extracellular1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA17892483

    Find genes that share ontologies with ZNHIT1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNHIT1
    Interactions:

        GeneGlobe Interaction Network for ZNHIT1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ZNHIT1 (O432571, 2, 3 ENSP000003045934) via UniProtKB, MINT, STRING, and/or I2D (see all 269)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000206406P678702, 3MINT-62614 MINT-62712 MINT-62788 I2D: score=4 
    ENSG00000224398P678702, 3MINT-62614 MINT-62712 MINT-62788 I2D: score=4 
    ENSG00000228875P678702, 3MINT-62614 MINT-62712 MINT-62788 I2D: score=4 
    ENSG00000230700P678702, 3MINT-62614 MINT-62712 MINT-62788 I2D: score=4 
    CSNK2BP678702, 3, ENSP000003650254MINT-62614 MINT-62712 MINT-62788 I2D: score=4 STRING: ENSP00000365025
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IEA--
    GO:0031063regulation of histone deacetylation IEA--
    GO:0042129regulation of T cell proliferation IEA--
    GO:0070317negative regulation of G0 to G1 transition IEA--

    Find genes that share ontologies with ZNHIT1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZNHIT1 (ZNHI1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ZNHIT1 gene: 
    NM_006349.2  

    Unigene Cluster for ZNHIT1:

    Zinc finger, HIT-type containing 1
    Hs.211079  [show with all ESTs]
    Unigene Representative Sequence: BM807959
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000305105(uc003uye.3) ENST00000461205 ENST00000492315(uc003uyf.3)
    ENST00000485387
    miRNA
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      QuantiTect SYBR Green Assays in human, mouse, rat ZNHIT1
      QuantiFast Probe-based Assays in human, mouse, rat ZNHIT1

    Additional mRNA sequence: 

    AF093571.1 AK312136.1 BC001877.1 BC017333.2 CR456992.1 U61837.1 

    13 DOTS entries:

    DT.446678  DT.95282626  DT.100674540  DT.100791402  DT.95260306  DT.99939154  DT.75176411  DT.91761063 
    DT.95260323  DT.91958992  DT.100791405  DT.121126478  DT.95260321 

    Selected AceView cDNA sequences (see all 386):

    BU508289 BF792955 BE385476 BQ920241 BQ082825 BI859688 BQ437550 CB108045 
    BQ012553 BI253076 BU157443 BM670523 CB159022 BG676319 BC010454 N53748 
    AA888038 AA809965 BF845162 BG030630 BM826155 BU615900 AL701885 AA293807 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ZNHIT1 (see all 8)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b
    SP1:                          -     -     -     -     -     -                                       
    SP2:                                      -     -     -     -                                       
    SP3:                                      -     -     -     -                                       
    SP4:              -     -     -     -     -     -     -     -                                       
    SP5:                          -     -     -     -                                                   


    ECgene alternative splicing isoforms for ZNHIT1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZNHIT1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCGAAAAGCT
    ZNHIT1 Expression
    About this image

    ZNHIT1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZNHIT1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.211079

    UniProtKB/Swiss-Prot: ZNHI1_HUMAN, O43257
    Tissue specificity: Expressed abundantly in liver, but weakly in skeletal muscle, ovary and small intestine

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ZNHIT1 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Znhit11 , 5 zinc finger, HIT domain containing 11, 5 88.66(n)1
    98.64(a)1
      5 (76.09 cM)5
    701031  NM_027318.31  NP_081594.11 
     1369821645 
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.69772 Xenopus laevis transcribed sequence with moderate similarity more 79.45(n)    AW640334.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.165732 Transcribed sequence with moderate similarity to protein more 76.52(n)    CD751216.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG319171 CG31917 57.76(n)
    56.16(a)
      326171  NM_135051.5  NP_608895.1 
    worm
    (Caenorhabditis elegans)
    Secernentea zhit-11 zhit-1 46.71(n)
    42.18(a)
      183878  NM_001129422.2  NP_001122894.1 


    ENSEMBL Gene Tree for ZNHIT1 (if available)
    TreeFam Gene Tree for ZNHIT1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZNHIT1 gene

    Find genes that share paralogs with ZNHIT1           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for ZNHIT1
    PGOHUM00000249811


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZNHIT1 (see all 138)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0357194
    A colorectal cancer sample4--see VAR_0357192 R W mis40--------
    rs1159502701,2
    C,F--100863082(+) TACCCC/TGCTGT 1 -- int11Minor allele frequency- T:0.24WA 118
    rs795282521,2
    --100863156(+) TTCCCC/TGACTA 1 -- int10--------
    rs1486471741,2
    --100863222(+) GTATCC/GTAGCC 1 -- int10--------
    rs1144722151,2
    C,F--100863233(+) TACTCC/AATGCT 1 -- int11Minor allele frequency- A:0.02WA 118
    rs752745611,2
    C,F--100863238(+) CATGCT/CGTACT 1 -- int12Minor allele frequency- C:0.05WA NA 238
    rs1420499821,2
    C--100863346(+) CAGAGG/TAGTAC 1 -- int10--------
    rs117679331,2
    C,H--100863392(+) TTTTGG/TGtttt 1 -- int11Minor allele frequency- T:0.50NA 2
    rs572256901,2
    C,F--100863575(+) TTTGTA/TTTTTT 1 -- int12Minor allele frequency- T:0.10WA 120
    rs1897598561,2
    --100863632(+) TCCCGC/TGCTCA 1 -- int10--------

    HapMap Linkage Disequilibrium report for ZNHIT1 (100860949 - 100867471 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for ZNHIT1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2734888CNV Deletion23290073
    esv2422376CNV Duplication17116639
    esv2422326CNV Duplication17116639
    nsv831075CNV Loss17160897
    nsv831076CNV Loss17160897
    dgv7409n71CNV Loss21882294
    dgv7410n71CNV Loss21882294
    esv2752134CNV Gain17911159

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZNHIT1 gene, integrated from 10 sources (see all 17):
    (articles sorted by number of sources associating them with ZNHIT1)
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    1. A zinc finger HIT domain-containing protein, ZNHIT-1, interacts with orphan nuclear hormone receptor Rev-erbbeta and removes Rev-erbbeta-induced inhibition of apoCIII transcription. (PubMed id 17892483)1, 2 Wang J....Lu H. (FEBS J. 2007)
    2. A new p38 MAP kinase-regulated transcriptional coactivator that stimulates p53-dependent apoptosis. (PubMed id 17380123)1, 2 Cuadrado A....Nebreda A.R. (EMBO J. 2007)
    3. The mammalian YL1 protein is a shared subunit of the TRRAP/TIP60 histone acetyltransferase and SRCAP complexes. (PubMed id 15647280)1, 2 Cai Y.... Conaway J.W. (J. Biol. Chem. 2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (Nature 2003)
    6. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    7. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    8. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    9. Essential role of p18Hamlet/SRCAP-mediated histone H2A.Z chromatin incorporation in muscle differentiation. (PubMed id 20473270)1 Cuadrado A....Nebreda A.R. (EMBO J. 2010)
    10. Protein interaction data set highlighted with human Ras-MAPK/PI3K signaling pathways. (PubMed id 18624398)1 Wang J....He F. (J. Proteome Res. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10467 HGNC: 21688 AceView: ZNHIT1 Ensembl:ENSG00000106400 euGenes: HUgn10467
    ECgene: ZNHIT1 H-InvDB: ZNHIT1

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZNHIT1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
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    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZNHIT1 gene:
    Search GeneIP for patents involving ZNHIT1

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