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Aliases for ZNHIT1 Gene

Aliases for ZNHIT1 Gene

  • Zinc Finger HIT-Type Containing 1 2 3
  • Zinc Finger Protein, Subfamily 4A (HIT Domain Containing), Member 1 2 3
  • Zinc Finger Protein Subfamily 4A Member 1 3 4
  • Putative Cyclin G1 Interacting Protein 2 3
  • Zinc Finger, HIT Domain Containing 1 2 3
  • Zinc Finger, HIT-Type Containing 1 3 5
  • Cyclin-G1-Binding Protein 1 3 4
  • P18 Hamlet 3 4
  • ZNFN4A1 3 4
  • Zinc Finger, HIT Type 1 3
  • H_DJ0747G18.14 3
  • P18Hamlet 3
  • CGBP1 4
  • CG1I 3

External Ids for ZNHIT1 Gene

Previous HGNC Symbols for ZNHIT1 Gene

  • ZNFN4A1

Previous GeneCards Identifiers for ZNHIT1 Gene

  • GC07P100407
  • GC07P100421
  • GC07P100454
  • GC07P100647
  • GC07P100860
  • GC07P095454

Summaries for ZNHIT1 Gene

GeneCards Summary for ZNHIT1 Gene

ZNHIT1 (Zinc Finger HIT-Type Containing 1) is a Protein Coding gene. GO annotations related to this gene include chromatin binding and nucleosome binding.

UniProtKB/Swiss-Prot for ZNHIT1 Gene

  • Seems to play a role in p53-mediated apoptosis induction. Binds to NR1D2 and relieves it of its inhibitory effect on the transcription of APOC3 without affecting its DNA-binding activity.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNHIT1 Gene

Genomics for ZNHIT1 Gene

Regulatory Elements for ZNHIT1 Gene

Promoters for ZNHIT1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNHIT1 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNHIT1 Gene

Chromosome:
7
Start:
101,217,668 bp from pter
End:
101,224,192 bp from pter
Size:
6,525 bases
Orientation:
Plus strand

Genomic View for ZNHIT1 Gene

Genes around ZNHIT1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNHIT1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNHIT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNHIT1 Gene

Proteins for ZNHIT1 Gene

  • Protein details for ZNHIT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43257-ZNHI1_HUMAN
    Recommended name:
    Zinc finger HIT domain-containing protein 1
    Protein Accession:
    O43257
    Secondary Accessions:
    • Q6IB12

    Protein attributes for ZNHIT1 Gene

    Size:
    154 amino acids
    Molecular mass:
    17536 Da
    Quaternary structure:
    • Interacts with MAPK11 and MAPK14. Component of the chromatin-remodeling SRCAP complex composed of at least SRCAP, DMAP1, RUVBL1, RUVBL2, ACTL6A, YEATS4, ACTR6 and ZNHIT1. Interacts with NR1D1 and NR2D2.

neXtProt entry for ZNHIT1 Gene

Proteomics data for ZNHIT1 Gene at MOPED

Post-translational modifications for ZNHIT1 Gene

Other Protein References for ZNHIT1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNHIT1 Gene

Domains & Families for ZNHIT1 Gene

Gene Families for ZNHIT1 Gene

Protein Domains for ZNHIT1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZNHIT1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O43257

UniProtKB/Swiss-Prot:

ZNHI1_HUMAN :
  • Belongs to the ZNHIT1 family.
  • Contains 1 HIT-type zinc finger.
Family:
  • Belongs to the ZNHIT1 family.
Similarity:
  • Contains 1 HIT-type zinc finger.
genes like me logo Genes that share domains with ZNHIT1: view

Function for ZNHIT1 Gene

Molecular function for ZNHIT1 Gene

UniProtKB/Swiss-Prot Function:
Seems to play a role in p53-mediated apoptosis induction. Binds to NR1D2 and relieves it of its inhibitory effect on the transcription of APOC3 without affecting its DNA-binding activity.
UniProtKB/Swiss-Prot Induction:
Induced by DNA damage.

Gene Ontology (GO) - Molecular Function for ZNHIT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042826 histone deacetylase binding IBA --
genes like me logo Genes that share ontologies with ZNHIT1: view
genes like me logo Genes that share phenotypes with ZNHIT1: view

Animal Model Products

miRNA for ZNHIT1 Gene

miRTarBase miRNAs that target ZNHIT1

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNHIT1 Gene

Localization for ZNHIT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNHIT1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNHIT1 Gene COMPARTMENTS Subcellular localization image for ZNHIT1 gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1

No data available for Gene Ontology (GO) - Cellular Components for ZNHIT1 Gene

Pathways & Interactions for ZNHIT1 Gene

SuperPathways for ZNHIT1 Gene

No Data Available

SIGNOR curated interactions for ZNHIT1 Gene

Activates:
Is activated by:
Other effect:

Gene Ontology (GO) - Biological Process for ZNHIT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043486 histone exchange IBA --
genes like me logo Genes that share ontologies with ZNHIT1: view

No data available for Pathways by source for ZNHIT1 Gene

Drugs & Compounds for ZNHIT1 Gene

No Compound Related Data Available

Transcripts for ZNHIT1 Gene

Unigene Clusters for ZNHIT1 Gene

Zinc finger, HIT-type containing 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNHIT1 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b
SP1: - - - - - -
SP2: - - - -
SP3: - - - -
SP4: - - - - - - - -
SP5: - - - -
SP6: - - -
SP7:
SP8:

Relevant External Links for ZNHIT1 Gene

GeneLoc Exon Structure for
ZNHIT1
ECgene alternative splicing isoforms for
ZNHIT1

Expression for ZNHIT1 Gene

mRNA expression in normal human tissues for ZNHIT1 Gene

Protein differential expression in normal tissues from HIPED for ZNHIT1 Gene

This gene is overexpressed in Heart (26.4), Testis (14.4), Blymphocyte (12.2), Placenta (8.3), and NK cells (7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZNHIT1 Gene



SOURCE GeneReport for Unigene cluster for ZNHIT1 Gene Hs.211079

mRNA Expression by UniProt/SwissProt for ZNHIT1 Gene

O43257-ZNHI1_HUMAN
Tissue specificity: Expressed abundantly in liver, but weakly in skeletal muscle, ovary and small intestine.
genes like me logo Genes that share expression patterns with ZNHIT1: view

Protein tissue co-expression partners for ZNHIT1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for ZNHIT1 Gene

Orthologs for ZNHIT1 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNHIT1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ZNHIT1 35
  • 93.29 (n)
  • 100 (a)
ZNHIT1 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZNHIT1 35
  • 91.99 (n)
  • 100 (a)
ZNHIT1 36
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Znhit1 35
  • 88.66 (n)
  • 98.64 (a)
Znhit1 16
Znhit1 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ZNHIT1 35
  • 99.35 (n)
  • 100 (a)
ZNHIT1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Znhit1 35
  • 87.53 (n)
  • 98.64 (a)
oppossum
(Monodelphis domestica)
Mammalia ZNHIT1 36
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZNHIT1 36
  • 54 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.1370 35
znhit1 35
  • 75.38 (n)
  • 83.01 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.6977 35
zebrafish
(Danio rerio)
Actinopterygii Dr.16573 35
znhit1 35
  • 72.51 (n)
  • 79.87 (a)
znhit1 36
  • 79 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007853 35
  • 56.08 (n)
  • 52.03 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG31917 35
  • 57.76 (n)
  • 56.16 (a)
CG31917 36
  • 50 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea zhit-1 35
  • 46.71 (n)
  • 42.18 (a)
zhit-1 36
  • 34 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 53 (a)
OneToOne
Species with no ortholog for ZNHIT1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZNHIT1 Gene

ENSEMBL:
Gene Tree for ZNHIT1 (if available)
TreeFam:
Gene Tree for ZNHIT1 (if available)

Paralogs for ZNHIT1 Gene

Pseudogenes.org Pseudogenes for ZNHIT1 Gene

genes like me logo Genes that share paralogs with ZNHIT1: view

No data available for Paralogs for ZNHIT1 Gene

Variants for ZNHIT1 Gene

Sequence variations from dbSNP and Humsavar for ZNHIT1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
VAR_035719 A colorectal cancer sample
rs12410 -- 101,224,014(+) GAAAG(A/C/G/T)CAGAA utr-variant-3-prime
rs14179 -- 101,223,747(+) CCCTT(C/T)TGTGC reference, synonymous-codon
rs1044491 -- 101,224,094(+) TGTGT(C/T)TTATC utr-variant-3-prime
rs1044500 -- 101,224,099(+) CTTAT(C/T)TGCCA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ZNHIT1 Gene

Variant ID Type Subtype PubMed ID
esv2734888 CNV Deletion 23290073
nsv831075 CNV Loss 17160897
esv2422376 CNV Duplication 17116639
dgv7409n71 CNV Loss 21882294
esv2752134 CNV Gain 17911159
nsv831076 CNV Loss 17160897
dgv7410n71 CNV Loss 21882294
esv2422326 CNV Duplication 17116639

Variation tolerance for ZNHIT1 Gene

Residual Variation Intolerance Score: 45.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.48; 10.41% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNHIT1 Gene

HapMap Linkage Disequilibrium report
ZNHIT1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNHIT1 Gene

Disorders for ZNHIT1 Gene

Relevant External Links for ZNHIT1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNHIT1

No disorders were found for ZNHIT1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNHIT1 Gene

Publications for ZNHIT1 Gene

  1. A zinc finger HIT domain-containing protein, ZNHIT-1, interacts with orphan nuclear hormone receptor Rev-erbbeta and removes Rev-erbbeta-induced inhibition of apoCIII transcription. (PMID: 17892483) Wang J. … Lu H. (FEBS J. 2007) 3 4 67
  2. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A. … Stelzl U. (Mol. Syst. Biol. 2015) 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. Essential role of p18Hamlet/SRCAP-mediated histone H2A.Z chromatin incorporation in muscle differentiation. (PMID: 20473270) Cuadrado A. … Nebreda A.R. (EMBO J. 2010) 3

Products for ZNHIT1 Gene

Sources for ZNHIT1 Gene

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