ZNHIT1 Gene
protein-coding GIFtS: 44
GCID: GC07P100860
|
|
zinc finger, HIT-type containing 1(Previous names: zinc finger protein, subfamily 4A (HIT domain containing),...)
(Previous symbol: ZNFN4A1)
| |
Aliases
for ZNHIT1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger, HIT-Type Containing 11 2 | | Zinc Finger Protein Subfamily 4A Member 12 3 | | ZNFN4A11 2 3 | | P18 Hamlet2 3 | | CG1I1 2 | | P18Hamlet1 | | H_DJ0747G18.141 2 | | Putative Cyclin G1 Interacting Protein2 | | Zinc Finger Protein, Subfamily 4A (HIT Domain Containing), Member 11 2 | | Zinc Finger HIT Domain-Containing Protein 12 | | Zinc Finger, HIT Domain Containing 11 2 | | Zinc Finger, HIT Type 12 | | Cyclin-G1-Binding Protein 12 3 | | CGBP13 |
Export aliases for ZNHIT1 gene to outside databasesPrevious GC identifers: GC07P100407 GC07P100421 GC07P100454 GC07P100647 GC07P095454 |
Summaries
for ZNHIT1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: ZNHI1_HUMAN, O43257Function: Seems to play a role in p53-mediated apoptosis induction
|
Genomic Views
for ZNHIT1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000007.13 NC_018918.1 NT_007933.15 NT_079596.2
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZNHIT1 gene promoter:
p53 HTF Olf-1 HNF-4alpha2 NF-kappaB FOXL1 HNF-4alpha1 NF-kappaB2 Pax-4a NF-kappaB1
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZNHIT1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNHIT1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 7q22.1 Ensembl cytogenetic band: 7q22.1 HGNC cytogenetic band: 7q22.1ZNHIT1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07P100860: view genomic region
(about GC identifiers)
Start:
|
100,860,949 bp from pter |
End:
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100,867,471 bp from pter |
Size:
|
6,523 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr7+,CRA_TCAG 100,219,372-100,225,858 |
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Proteins
for ZNHIT1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZNHI1_HUMAN, O43257 (See
protein sequence)Recommended Name: Zinc finger HIT domain-containing protein 1 Size: 154 amino acids; 17536 Da
Subunit: Interacts with MAPK11 and MAPK14. Component of the chromatin-remodeling SRCAP complex composed of at leastSRCAP, DMAP1, RUVBL1, RUVBL2, ACTL6A, YEATS4, ACTR6 and ZNHIT1
Secondary accessions: Q6IB12Explore the universe of human proteins at neXtProt for ZNHIT1: NX_O43257
Post-translational modifications:
Phosphorylated on Thr by MAPK11 or MAPK141
Stres-induced ZNHIT1 is mainly regulated at the level of protein1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O43257
ZNHIT1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_006340.1
ENSEMBL proteins: ENSP00000304593
Human Recombinant Protein Products:
ZNHIT1 Antibody Products:
Assay Products for ZNHIT1: |
Protein
Domains /
Families
for ZNHIT1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZNHIT1 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry O43257ProtoNet protein and cluster: O43257 UniProtKB/Swiss-Prot: ZNHI1_HUMAN, O43257Similarity: Belongs to the ZNHIT1 familySimilarity: Contains 1 HIT-type zinc finger |
Function
for ZNHIT1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ZNHI1_HUMAN, O43257Function: Seems to play a role in p53-mediated apoptosis inductionInduction: Induced by DNA damage
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNHIT1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNHIT1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNHIT1 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
ZNHIT1 for ontologies About GeneDecksing
|
Pathways & Interactions
for ZNHIT1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ZNHIT1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 23)
5/26 Interacting proteins for ZNHIT1 (O432572, 3 ENSP000003045934) via UniProtKB, MINT, STRING, and/or I2D (see all 26)About this table
|
Drugs & Compounds
for ZNHIT1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZNHIT1
Search CenterWatch for drugs/clinical trials and news about ZNHIT1 / ZNHI1
|
Transcripts
for ZNHIT1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZNHIT1 gene: NM_006349.2 Unigene Cluster for ZNHIT1: Zinc finger, HIT-type containing 1 Hs.211079 [show with all ESTs]Unigene Representative Sequence: BM8079594 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000305105(uc003uye.3) ENST00000461205 ENST00000492315(uc003uyf.3)
ENST00000485387
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNHIT1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNHIT1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ZNHIT1 (NM_006349) | | | DNA2.0 Custom Codon Optimized Gene
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Additional cDNA sequence: AF093571.1 AK312136.1 BC001877.1 BC017333.2 CR456992.1 U61837.1 13 DOTS entries: DT.446678 DT.95282626 DT.100674540 DT.100791402 DT.95260306 DT.99939154 DT.75176411 DT.91761063 DT.95260323 DT.91958992 DT.100791405 DT.121126478 DT.95260321 24/386 AceView cDNA sequences (see all 386): CR597071 AI083841 BE902948 CA312608 BG030630 BQ433305 BE908095 BC017333 CA947089 CB113139 BQ012553 BE047672 BF727178 BU738263 CA942657 AI734107 BU615900 BG768658 BM792797 CF529967 BM020224 BU157443 BM700407 AI352704
GeneLoc Exon Structure
5/8 Alternative Splicing Database (ASD) splice patterns (SP) for ZNHIT1 (see all 8) About this scheme
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b |
|---|
|
| SP1: | | | | | | | | | - | | - | | - | | - | | - | | - | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | - | | - | | - | | - | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | - | | - | | - | | - | | | | | | | | | | | | | | |
| SP4: | | | | | - | | - | | - | | - | | - | | - | | - | | - | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | - | | - | | - | | - | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for ZNHIT1
|
Expression
for ZNHIT1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZNHIT1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCGAAAAGCT
About this image
See ZNHIT1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZNHIT1
SOURCE GeneReport for Unigene cluster: Hs.211079
SABiosciences Custom PCR Arrays for ZNHIT1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNHIT1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ZNHIT1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNHIT1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNHIT1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNHIT1 |
Orthologs
for ZNHIT1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for ZNHIT1 gene from 7/23 species (see all 23) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Znhit11 , 5 |
zinc finger, HIT domain containing 11, 5 |
88.66(n)1
98.64(a)1 |
|
5 (76.09 cM)5
701031 NM_027318.31 NP_081594.11
1369821645 |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.69772 |
Xenopus laevis transcribed sequence with moderate similarity more |
79.45(n) |
|
AW640334.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
Dr.165732 |
Transcribed sequence with moderate similarity to protein more |
76.52(n) |
|
CD751216.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG319171 |
CG31917 |
58.16(n)
56.55(a) |
|
326171 NM_135051.4 NP_608895.1 |
worm
(Caenorhabditis elegans) |
Secernentea |
zhit-11 |
Protein ZHIT-1 |
47.85(n)
45.58(a) |
|
183878 NM_001129422.1 NP_001122894.1 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
ATSWC66 |
zinc finger HIT domain-containing protein 1 |
29(a) |
1 ↔ 1 |
5(14641551-14642440) |
rice
(Oryza sativa) |
Liliopsida |
-- |
HIT zinc finger domain containing protein, express... |
27(a) |
1 ↔ 1 |
3(14423318-14426558) |
ENSEMBL Gene Tree for ZNHIT1 (if available)
TreeFam Gene Tree for ZNHIT1 (if available) |
Paralogs
for ZNHIT1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ZNHIT1 gene
ZNHIT1 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for ZNHIT1
PGOHUM00000249811
|
Genomic Variants
for ZNHIT1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 7 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZNHIT1 (100860949 - 100867471 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for ZNHIT1
3 CNVs: 5244 8576 5245 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNHIT1 |
|
Disorders
/ Diseases
for ZNHIT1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for ZNHIT1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZNHIT1 gene, integrated from 9 sources (see all 14):
(articles sorted by number of sources associating them with ZNHIT1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A new p38 MAP kinase-regulated transcriptional coactivator that stimulates p53-dependent apoptosis. (PubMed id 17380123)1, 2 Cuadrado A....Nebreda A.R. (2007)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (2003)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Essential role of p18Hamlet/SRCAP-mediated histone H2A .Z chromatin incorporation in muscle differentiation. (PubMed id 20473270)1 Cuadrado A....Nebreda A.R. (2010)
- Protein interaction data set highlighted with human Ras-MAPK/PI3K signaling pathways. (PubMed id 18624398)1 Wang J....He F. (2008)
- The interactome of the histone gene regulatory factor HiNF-P suggests novel cell cycle related roles in transcriptional control and RNA processing. (PubMed id 17577209)1 Miele A....Stein J.L. (2007)
- p18(Hamlet) mediates different p53-dependent responses to DNA-damage inducing agents. (PubMed id 17700068)1 Lafarga V....Nebreda A.R. (2007)
- The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (2006)
- The mammalian YL1 protein is a shared subunit of the TRRAP/TIP60 histone acetyltransferase and SRCAP complexes. (PubMed id 15647280)2 Cai Y.... Conaway J.W. (2005)
|
External Searches for ZNHIT1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZNHIT1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZNHIT1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZNHIT1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZNHIT1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZNHIT1 gene:
Search GeneIP for patents involving ZNHIT1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZNHIT1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| |
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| |  |  |  |  | | | | |
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 |
 |
 | | | ZNHIT1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNHIT1 |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNHIT1 |
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