ZNFX1 Gene
protein-coding GIFtS: 45
GCID: GC20M047854
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|
zinc finger, NFX1-type containing 1
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Aliases
for ZNFX1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger, NFX1-Type Containing 11 2 | | KIAA14041 3 | | FLJ112771 | | NFX1-Type Zinc Finger-Containing Protein 12 |
Export aliases for ZNFX1 gene to outside databasesPrevious GC identifers: GC20M047287 GC20M047296 GC20M044611 |
Summaries
for ZNFX1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for ZNFX1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000020.10 NC_018931.1 NT_011362.10
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZNFX1 gene promoter:
Bach1 Sp1 HOXA3 AML1a HTF Ik-3 LCR-F1 HFH-1 ATF6
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZNFX1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNFX1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 20q13.13 Ensembl cytogenetic band: 20q13.13 HGNC cytogenetic band: 20q13.13ZNFX1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 20 GeneLoc Exon Structure GeneLoc location for GC20M047854: view genomic region
(about GC identifiers)
Start:
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47,854,483 bp from pter |
End:
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47,894,963 bp from pter |
Size:
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40,481 bases |
Orientation:
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minus strand |
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Proteins
for ZNFX1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZNFX1_HUMAN, Q9P2E3 (See
protein sequence)Recommended Name: NFX1-type zinc finger-containing protein 1 Size: 1918 amino acids; 220227 Da
Sequence caution: Sequence=BAA91264.1; Type=Erroneous initiation; Sequence=BAA92642.1; Type=Erroneous initiation;Sequence=BAB14149.1; Type=Erroneous initiation; Sequence=BAB14696.1; Type=Erroneous termination; Positions=1846;Note=Translated as Trp;
Secondary accessions: Q9BQM7 Q9BQM8 Q9H8C1 Q9H9S2 Q9NUM1 Q9NWW1Alternative splicing: 2 isoforms: Q9P2E3-1 Q9P2E3-2 Explore the universe of human proteins at neXtProt for ZNFX1: NX_Q9P2E3
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9P2E3
ZNFX1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_066363.1
ENSEMBL proteins: ENSP00000360819 ENSP00000360817 ENSP00000360809 ENSP00000413800 ENSP00000379412
Human Recombinant Protein Products:
ZNFX1 Antibody Products:
Assay Products for ZNFX1: |
Protein
Domains /
Families
for ZNFX1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q9P2E3 1 Blocks protein family: IPB001368 TNFR/CD27/30/40/95 cysteine-rich region
UniProtKB/Swiss-Prot: ZNFX1_HUMAN, Q9P2E3Similarity: Contains 6 NF-X1-type zinc fingers |
Function
for ZNFX1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNFX1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNFX1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: ZNFX1 (NM_021035) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNFX1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNFX1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNFX1 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0046872 | metal ion binding |
IEA | -- |
ZNFX1 for ontologies About GeneDecksing
|
Pathways & Interactions
for ZNFX1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNFX1
STRING Interaction
Network Preview (showing 5 interactants - click image to see more details)
5 Interacting proteins for ZNFX1 (Q9P2E33 ENSP000003608174) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for ZNFX1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZNFX1
Search CenterWatch for drugs/clinical trials and news about ZNFX1
|
Transcripts
for ZNFX1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZNFX1 gene: NM_021035.2 Unigene Cluster for ZNFX1: Zinc finger, NFX1-type containing 1 Hs.371794 [show with all ESTs]Unigene Representative Sequence: NM_0210356 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000371754 ENST00000469991 ENST00000371752 ENST00000371744 ENST00000455070
ENST00000396105(uc002xui.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNFX1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNFX1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ZNFX1 (NM_021035) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNFX1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNFX1 |
Additional cDNA sequence: AB037825.2 AK000573.1 AK002139.1 AK022226.1 AK022641.1 AK023836.1 AK096594.1 AK307392.1 BC014041.2 BC030789.1 BC041630.1 BC062347.1 BC110888.1 21 DOTS entries: DT.95303736 DT.215476 DT.95366698 DT.101982243 DT.100781751 DT.65287656 DT.99999819 DT.97799356 DT.100028348 DT.97763707 DT.75159797 DT.95103708 DT.95303735 DT.100651867 DT.120795508 DT.121460060 DT.75193936 DT.91920233 DT.95152227 DT.95222599 DT.95303732 24/241 AceView cDNA sequences (see all 241): BC014041 BF477818 AW027734 BQ892171 BQ673498 AK002139 BQ932293 BQ774196 NM_021035 BQ425345 BE674545 BG328752 BQ888741 AA478774 AL708008 AI312009 BQ774733 BU150445 AL449612 BM128654 AI243980 CB529692 AL449863 AI040211
GeneLoc Exon Structure
5/7 Alternative Splicing Database (ASD) splice patterns (SP) for ZNFX1 (see all 7) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10a | · | 10b | · | 10c | · | 10d | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 |
|---|
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| SP1: | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for ZNFX1
|
Expression
for ZNFX1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZNFX1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCAGCAGCTT
About this image
See ZNFX1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZNFX1
SOURCE GeneReport for Unigene cluster: Hs.371794
UniProtKB/Swiss-Prot: ZNFX1_HUMAN, Q9P2E3Tissue specificity: Widely expressed
SABiosciences Custom PCR Arrays for ZNFX1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNFX1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ZNFX1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNFX1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNFX1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNFX1 |
Orthologs
for ZNFX1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for ZNFX1 gene from 5/24 species (see all 24) About this table
ENSEMBL Gene Tree for ZNFX1 (if available)
TreeFam Gene Tree for ZNFX1 (if available) |
Paralogs
for ZNFX1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ZNFX1 gene
- AQR2 UPF12 C4orf212
ZNFX1 for paralogs About GeneDecksing
|
Genomic Variants
for ZNFX1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 20 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZNFX1 (47854483 - 47894963 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for ZNFX1
1 Indel: 26844 | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for ZNFX1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ZNFX1 for disorders About GeneDecksing
3  diseases for ZNFX1: About MalaCardsprostate cancer prostatitis malaria
Export disorders for ZNFX1 gene to outside databases
|
Publications
for ZNFX1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZNFX1 gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with ZNFX1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198)1, 2, 3 Nagase T.... Ohara O. (2000)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Hundreds of variants clustered in genomic loci and bi ological pathways affect human height. (PubMed id 20881960)1 Lango Allen H....Hirschhorn J.N. (2010)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- Antigen-specific IgG elicited in subjects with prostate cancer treated with flt3 ligand. (PubMed id 15838384)1 Dunphy E.J. and McNeel D.G. (2005)
- Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs. (PubMed id 12421765)1 Nakayama M....Ohara O. (2002)
|
External Searches for ZNFX1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZNFX1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZNFX1 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing ZNFX1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZNFX1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZNFX1 gene:
Search GeneIP for patents involving ZNFX1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZNFX1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ZNFX1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZNFX1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNFX1 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ZNFX1 | | OriGene 3'-UTR Clone for ZNFX1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNFX1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNFX1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for ZNFX1 | | OriGene Custom Protein Services for ZNFX1 | | | OriGene Custom Immunoassay Development | | |
| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ZNFX1 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNFX1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNFX1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZNFX1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNFX1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNFX1 |
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| | | | Search Tocris compounds for ZNFX1 |
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 | | | ZNFX1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNFX1 |
|  |  |  | | | | Search ThermoFisher Antibodies for ZNFX1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNFX1 |
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