Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ZNFX1 Gene

Aliases for ZNFX1 Gene

  • Zinc Finger NFX1-Type Containing 1 2 3
  • Zinc Finger, NFX1-Type Containing 1 2 5
  • KIAA1404 4

External Ids for ZNFX1 Gene

Previous GeneCards Identifiers for ZNFX1 Gene

  • GC20M047287
  • GC20M047296
  • GC20M047854
  • GC20M044611

Summaries for ZNFX1 Gene

GeneCards Summary for ZNFX1 Gene

ZNFX1 (Zinc Finger NFX1-Type Containing 1) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding and binding. An important paralog of this gene is AQR.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNFX1 Gene

Genomics for ZNFX1 Gene

Regulatory Elements for ZNFX1 Gene

Enhancers for ZNFX1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZNFX1 on UCSC Golden Path with GeneCards custom track

Promoters for ZNFX1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNFX1 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNFX1 Gene

Chromosome:
20
Start:
49,237,946 bp from pter
End:
49,278,426 bp from pter
Size:
40,481 bases
Orientation:
Minus strand

Genomic View for ZNFX1 Gene

Genes around ZNFX1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNFX1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNFX1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNFX1 Gene

Proteins for ZNFX1 Gene

  • Protein details for ZNFX1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P2E3-ZNFX1_HUMAN
    Recommended name:
    NFX1-type zinc finger-containing protein 1
    Protein Accession:
    Q9P2E3
    Secondary Accessions:
    • Q9BQM7
    • Q9BQM8
    • Q9H8C1
    • Q9H9S2
    • Q9NUM1
    • Q9NWW1

    Protein attributes for ZNFX1 Gene

    Size:
    1918 amino acids
    Molecular mass:
    220227 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA91264.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA92642.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB14149.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB14696.1; Type=Erroneous termination; Positions=1846; Note=Translated as Trp.; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNFX1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNFX1 Gene

Proteomics data for ZNFX1 Gene at MOPED

Post-translational modifications for ZNFX1 Gene

  • Ubiquitination at Lys 544
  • Modification sites at PhosphoSitePlus

Other Protein References for ZNFX1 Gene

No data available for DME Specific Peptides for ZNFX1 Gene

Domains & Families for ZNFX1 Gene

Gene Families for ZNFX1 Gene

Protein Domains for ZNFX1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9P2E3

UniProtKB/Swiss-Prot:

ZNFX1_HUMAN :
  • Contains 6 NF-X1-type zinc fingers.
Similarity:
  • Contains 6 NF-X1-type zinc fingers.
genes like me logo Genes that share domains with ZNFX1: view

Function for ZNFX1 Gene

Gene Ontology (GO) - Molecular Function for ZNFX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005488 binding IEA --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with ZNFX1: view
genes like me logo Genes that share phenotypes with ZNFX1: view

Animal Model Products

miRNA for ZNFX1 Gene

miRTarBase miRNAs that target ZNFX1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNFX1 Gene

Localization for ZNFX1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNFX1 Gene COMPARTMENTS Subcellular localization image for ZNFX1 gene
Compartment Confidence
mitochondrion 3
cytosol 2
nucleus 2
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ZNFX1 Gene

Pathways & Interactions for ZNFX1 Gene

SuperPathways for ZNFX1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNFX1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ZNFX1 Gene

Drugs & Compounds for ZNFX1 Gene

No Compound Related Data Available

Transcripts for ZNFX1 Gene

Unigene Clusters for ZNFX1 Gene

Zinc finger, NFX1-type containing 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNFX1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c · 10d ^ 11 ^ 12 ^ 13 ^ 14 ^ 15
SP1: -
SP2:
SP3: -
SP4:
SP5:
SP6: -
SP7: - -

Relevant External Links for ZNFX1 Gene

GeneLoc Exon Structure for
ZNFX1
ECgene alternative splicing isoforms for
ZNFX1

Expression for ZNFX1 Gene

mRNA expression in normal human tissues for ZNFX1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZNFX1 Gene

This gene is overexpressed in Heart (18.3), Adrenal (13.7), and Plasma (9.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZNFX1 Gene



SOURCE GeneReport for Unigene cluster for ZNFX1 Gene Hs.371794

mRNA Expression by UniProt/SwissProt for ZNFX1 Gene

Q9P2E3-ZNFX1_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expression patterns with ZNFX1: view

Protein tissue co-expression partners for ZNFX1 Gene

Primer Products

No data available for mRNA differential expression in normal tissues for ZNFX1 Gene

Orthologs for ZNFX1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ZNFX1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ZNFX1 35
  • 88.62 (n)
  • 89.04 (a)
ZNFX1 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZNFX1 35
  • 89.93 (n)
  • 91.18 (a)
ZNFX1 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Znfx1 35
  • 85.98 (n)
  • 88.06 (a)
Znfx1 16
Znfx1 36
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ZNFX1 35
  • 99.57 (n)
  • 99.74 (a)
ZNFX1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Znfx1 35
  • 86.04 (n)
  • 87.61 (a)
oppossum
(Monodelphis domestica)
Mammalia ZNFX1 36
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 77 (a)
OneToMany
-- 36
  • 54 (a)
OneToMany
chicken
(Gallus gallus)
Aves ZNFX1 35
  • 67.95 (n)
  • 68.38 (a)
ZNFX1 36
  • 62 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 45 (a)
OneToMany
-- 36
  • 43 (a)
OneToMany
-- 36
  • 53 (a)
OneToMany
-- 36
  • 61 (a)
OneToMany
-- 36
  • 55 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100486840 35
  • 62.54 (n)
  • 61.86 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100536767 35
  • 59.25 (n)
  • 56.79 (a)
ZNFX1 36
  • 53 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006235 35
  • 47.76 (n)
  • 37.95 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG6204 35
  • 45.61 (n)
  • 36.67 (a)
CG6204 36
  • 30 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea ZK1067.2 36
  • 22 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SEN1 36
  • 10 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 42 (a)
OneToMany
-- 36
  • 49 (a)
OneToMany
-- 36
  • 52 (a)
OneToMany
Species with no ortholog for ZNFX1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZNFX1 Gene

ENSEMBL:
Gene Tree for ZNFX1 (if available)
TreeFam:
Gene Tree for ZNFX1 (if available)

Paralogs for ZNFX1 Gene

Paralogs for ZNFX1 Gene

genes like me logo Genes that share paralogs with ZNFX1: view

Variants for ZNFX1 Gene

Sequence variations from dbSNP and Humsavar for ZNFX1 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs2664578 - 49,257,491(+) CAGAA(C/G)CATTT reference, missense
rs2273148 - 49,255,884(+) CATGG(C/G/T)GTTCA reference, missense
rs238221 - 49,255,840(-) TGGCA(C/G)CTGGA reference, missense
rs238209 - 49,248,972(-) CAAAA(C/T)CATTC reference, missense
rs6512577 - 49,249,247(+) CGGAG(C/T)ATGGG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for ZNFX1 Gene

Variant ID Type Subtype PubMed ID
esv1336829 CNV Deletion 17803354
nsv437839 CNV Loss 16327808

Variation tolerance for ZNFX1 Gene

Residual Variation Intolerance Score: 11.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.49; 71.75% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ZNFX1 Gene

Disorders for ZNFX1 Gene

Relevant External Links for ZNFX1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNFX1

No disorders were found for ZNFX1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNFX1 Gene

Publications for ZNFX1 Gene

  1. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10718198) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4 67
  2. A novel common variant in DCST2 is associated with length in early life and height in adulthood. (PMID: 25281659) van der Valk R.J. … Jaddoe V.W. (Hum. Mol. Genet. 2015) 3
  3. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  4. A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning. (PMID: 26673895) KA+rlA+ K. … GAPrlich D. (Elife 2015) 3
  5. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 3

Products for ZNFX1 Gene

Sources for ZNFX1 Gene

Content