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Aliases for ZNFX1 Gene

Aliases for ZNFX1 Gene

  • Zinc Finger NFX1-Type Containing 1 2 3 5
  • Zinc Finger, NFX1-Type Containing 1 2
  • KIAA1404 4

External Ids for ZNFX1 Gene

Previous GeneCards Identifiers for ZNFX1 Gene

  • GC20M047287
  • GC20M047296
  • GC20M047854
  • GC20M044611

Summaries for ZNFX1 Gene

GeneCards Summary for ZNFX1 Gene

ZNFX1 (Zinc Finger NFX1-Type Containing 1) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding and binding. An important paralog of this gene is AQR.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNFX1 Gene

Genomics for ZNFX1 Gene

Regulatory Elements for ZNFX1 Gene

Enhancers for ZNFX1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20G049275 2.1 FANTOM5 Ensembl ENCODE dbSUPER 24 -1.5 -1529 9.2 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF416 ZNF143 CSE1L ZNFX1 ZFAS1 SNORD12B B4GALT5 SNORD12 ARFGEF2 GC20P049304 ENSG00000274760
GH20G049671 2.3 VISTA FANTOM5 Ensembl ENCODE dbSUPER 14.3 -398.7 -398717 11.7 HNRNPUL1 HDGF PKNOX1 FOXA2 MLX ZFP64 WRNIP1 ARID4B SIN3A DMAP1 SLC9A8 B4GALT5 RNF114 ZNFX1 RNU6-919P ENSG00000232043 SNAI1 LINC01273 ARFGEF2 TMEM189
GH20G049698 2 FANTOM5 Ensembl ENCODE dbSUPER 15.1 -422.5 -422476 5.8 HDGF PKNOX1 WRNIP1 SIN3A ZNF207 FOS DEK ZNF263 JUNB REST SLC9A8 SNAI1 B4GALT5 ZNFX1 CEBPB TMEM189 RNF114 GC20M049705 GC20M049629
GH20G048816 2 FANTOM5 Ensembl ENCODE dbSUPER 14.2 +455.6 455578 13.5 HDGF FOXA2 PKNOX1 ARNT CREB3L1 WRNIP1 SIN3A DMAP1 YBX1 ZNF2 PREX1 ZNFX1 STAU1 GC20P048702
GH20G049762 2.1 FANTOM5 Ensembl ENCODE dbSUPER 12.7 -491.8 -491823 14.7 MLX ZFP64 DMAP1 YBX1 YY1 SLC30A9 ZNF143 SP3 NFYC TBX21 SLC9A8 SNAI1 B4GALT5 CEBPB RNU6-919P ZNFX1 PTGIS LINC01273 KCNB1 RNF114
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNFX1 on UCSC Golden Path with GeneCards custom track

Promoters for ZNFX1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000138214 226 3601 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF416 ZNF143

Genomic Location for ZNFX1 Gene

Chromosome:
20
Start:
49,237,946 bp from pter
End:
49,278,426 bp from pter
Size:
40,481 bases
Orientation:
Minus strand

Genomic View for ZNFX1 Gene

Genes around ZNFX1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNFX1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNFX1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNFX1 Gene

Proteins for ZNFX1 Gene

  • Protein details for ZNFX1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P2E3-ZNFX1_HUMAN
    Recommended name:
    NFX1-type zinc finger-containing protein 1
    Protein Accession:
    Q9P2E3
    Secondary Accessions:
    • Q9BQM7
    • Q9BQM8
    • Q9H8C1
    • Q9H9S2
    • Q9NUM1
    • Q9NWW1

    Protein attributes for ZNFX1 Gene

    Size:
    1918 amino acids
    Molecular mass:
    220227 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA91264.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA92642.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB14149.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB14696.1; Type=Erroneous termination; Positions=1846; Note=Translated as Trp.; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNFX1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNFX1 Gene

Post-translational modifications for ZNFX1 Gene

  • Ubiquitination at isoforms=2544
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ZNFX1 Gene

Domains & Families for ZNFX1 Gene

Gene Families for ZNFX1 Gene

Protein Domains for ZNFX1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ZNFX1: view

No data available for UniProtKB/Swiss-Prot for ZNFX1 Gene

Function for ZNFX1 Gene

Gene Ontology (GO) - Molecular Function for ZNFX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003700 transcription factor activity, sequence-specific DNA binding IEA --
GO:0003723 RNA binding IDA 22658674
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNFX1: view
genes like me logo Genes that share phenotypes with ZNFX1: view

Animal Model Products

CRISPR Products

miRNA for ZNFX1 Gene

miRTarBase miRNAs that target ZNFX1

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNFX1 Gene

Localization for ZNFX1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNFX1 gene
Compartment Confidence
mitochondrion 3
nucleus 3
cytosol 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for ZNFX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNFX1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ZNFX1 Gene

Pathways & Interactions for ZNFX1 Gene

SuperPathways for ZNFX1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNFX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNFX1: view

No data available for Pathways by source and SIGNOR curated interactions for ZNFX1 Gene

Drugs & Compounds for ZNFX1 Gene

No Compound Related Data Available

Transcripts for ZNFX1 Gene

Unigene Clusters for ZNFX1 Gene

Zinc finger, NFX1-type containing 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNFX1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c · 10d ^ 11 ^ 12 ^ 13 ^ 14 ^ 15
SP1: -
SP2:
SP3: -
SP4:
SP5:
SP6: -
SP7: - -

Relevant External Links for ZNFX1 Gene

GeneLoc Exon Structure for
ZNFX1
ECgene alternative splicing isoforms for
ZNFX1

Expression for ZNFX1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNFX1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZNFX1 Gene

This gene is overexpressed in Heart (18.3), Adrenal (13.7), and Plasma (9.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZNFX1 Gene



Protein tissue co-expression partners for ZNFX1 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNFX1 Gene:

ZNFX1

SOURCE GeneReport for Unigene cluster for ZNFX1 Gene:

Hs.371794

mRNA Expression by UniProt/SwissProt for ZNFX1 Gene:

Q9P2E3-ZNFX1_HUMAN
Tissue specificity: Widely expressed.

Evidence on tissue expression from TISSUES for ZNFX1 Gene

  • Nervous system(4.4)
  • Lung(2.7)
genes like me logo Genes that share expression patterns with ZNFX1: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNFX1 Gene

Orthologs for ZNFX1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ZNFX1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNFX1 34 35
  • 99.57 (n)
dog
(Canis familiaris)
Mammalia ZNFX1 34 35
  • 89.93 (n)
cow
(Bos Taurus)
Mammalia ZNFX1 34 35
  • 88.62 (n)
rat
(Rattus norvegicus)
Mammalia Znfx1 34
  • 86.04 (n)
mouse
(Mus musculus)
Mammalia Znfx1 34 16 35
  • 85.98 (n)
oppossum
(Monodelphis domestica)
Mammalia ZNFX1 35
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 77 (a)
OneToMany
-- 35
  • 54 (a)
OneToMany
chicken
(Gallus gallus)
Aves ZNFX1 34 35
  • 67.95 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 61 (a)
OneToMany
-- 35
  • 55 (a)
OneToMany
-- 35
  • 53 (a)
OneToMany
-- 35
  • 45 (a)
OneToMany
-- 35
  • 43 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100486840 34
  • 62.54 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC100536767 34
  • 59.25 (n)
ZNFX1 35
  • 53 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006235 34
  • 47.76 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG6204 34 35
  • 45.61 (n)
worm
(Caenorhabditis elegans)
Secernentea ZK1067.2 35
  • 22 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SEN1 35
  • 10 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 52 (a)
OneToMany
-- 35
  • 49 (a)
OneToMany
-- 35
  • 42 (a)
OneToMany
Species where no ortholog for ZNFX1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZNFX1 Gene

ENSEMBL:
Gene Tree for ZNFX1 (if available)
TreeFam:
Gene Tree for ZNFX1 (if available)

Paralogs for ZNFX1 Gene

Paralogs for ZNFX1 Gene

genes like me logo Genes that share paralogs with ZNFX1: view

Variants for ZNFX1 Gene

Sequence variations from dbSNP and Humsavar for ZNFX1 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs1000042643 -- 49,277,336(+) TGTGA(C/G)GTGGC intron-variant, upstream-variant-2KB
rs1000070514 -- 49,279,695(+) AGGTT(C/T)CTGGT intron-variant, upstream-variant-2KB
rs1000085785 -- 49,274,637(+) ACCTG(C/T)AATCC intron-variant
rs1000262921 -- 49,267,456(+) CAAGA(C/T)GTCCA intron-variant
rs1000314916 -- 49,250,983(+) GGATT(A/G)CAGGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNFX1 Gene

Variant ID Type Subtype PubMed ID
dgv1248e212 CNV loss 25503493
esv1336829 CNV deletion 17803354
esv3445061 CNV duplication 20981092
nsv1064443 CNV gain 25217958
nsv1067146 CNV loss 25217958
nsv1072545 CNV deletion 25765185
nsv437839 CNV loss 16327808
nsv476410 CNV novel sequence insertion 20440878

Variation tolerance for ZNFX1 Gene

Residual Variation Intolerance Score: 11.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.49; 71.75% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNFX1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNFX1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNFX1 Gene

Disorders for ZNFX1 Gene

Relevant External Links for ZNFX1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNFX1

No disorders were found for ZNFX1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNFX1 Gene

Publications for ZNFX1 Gene

  1. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10718198) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4 64
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64
  5. A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning. (PMID: 26673895) KA+rlA+ K. … GAPrlich D. (Elife 2015) 3 64

Products for ZNFX1 Gene

Sources for ZNFX1 Gene

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