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Aliases for ZNFX1 Gene

Aliases for ZNFX1 Gene

  • Zinc Finger NFX1-Type Containing 1 2 3 5
  • Zinc Finger, NFX1-Type Containing 1 2
  • KIAA1404 4

External Ids for ZNFX1 Gene

Previous GeneCards Identifiers for ZNFX1 Gene

  • GC20M047287
  • GC20M047296
  • GC20M047854
  • GC20M044611

Summaries for ZNFX1 Gene

GeneCards Summary for ZNFX1 Gene

ZNFX1 (Zinc Finger NFX1-Type Containing 1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include binding. An important paralog of this gene is AQR.

Additional gene information for ZNFX1 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNFX1 Gene

Genomics for ZNFX1 Gene

GeneHancer (GH) Regulatory Elements for ZNFX1 Gene

Promoters and enhancers for ZNFX1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20I049275 Promoter/Enhancer 2.9 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 593.6 -1.5 -1529 9.2 CLOCK MLX ZFP64 FEZF1 DMAP1 YBX1 IRF4 YY1 SLC30A9 ZNF213 ZNFX1 SNORD12B ZFAS1 SNORD12 ENSG00000277830 ENSG00000277967 GC20P049313 GC20P049317 GC20P049318 GC20P049319
GH20I048816 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 14.2 +455.6 455578 13.5 HDGF PKNOX1 ARNT NEUROD1 SIN3A YBX1 ZNF2 ZBTB7B IRF4 E2F8 PREX1 DDX27 ZNFX1 CSE1L SLC9A8 STAU1 LOC105372648 GC20P048702
GH20I049671 Enhancer 2 VISTA FANTOM5 Ensembl ENCODE dbSUPER 14.3 -398.7 -398716 11.7 HDGF PKNOX1 FOXA2 MLX ZFP64 ARID4B SIN3A DMAP1 IRF4 YY1 SLC9A8 B4GALT5 RNF114 ZNFX1 RNU6-919P SNAI1 DDX27 TMEM189 GC20M049705 GC20M049629
GH20I049698 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 15.1 -422.5 -422475 5.8 HDGF PKNOX1 ATF1 IRF4 ZNF121 FOS ATF7 RUNX3 DEK JUNB SLC9A8 SNAI1 B4GALT5 ZNFX1 CEBPB TMEM189 RNF114 GC20M049705 GC20M049629
GH20I049762 Enhancer 1.9 FANTOM5 Ensembl ENCODE dbSUPER 12.7 -491.8 -491823 14.7 MLX ZFP64 DMAP1 IRF4 YY1 SLC30A9 SP3 NFYC PPARGC1A MEF2D SLC9A8 SNAI1 DDX27 B4GALT5 CEBPB RNU6-919P ZNFX1 ARFGEF2 KCNB1 KRT18P4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNFX1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNFX1 gene promoter:

Genomic Locations for ZNFX1 Gene

Genomic Locations for ZNFX1 Gene
40,481 bases
Minus strand

Genomic View for ZNFX1 Gene

Genes around ZNFX1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNFX1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNFX1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNFX1 Gene

Proteins for ZNFX1 Gene

  • Protein details for ZNFX1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    NFX1-type zinc finger-containing protein 1
    Protein Accession:
    Secondary Accessions:
    • Q9BQM7
    • Q9BQM8
    • Q9H8C1
    • Q9H9S2
    • Q9NUM1
    • Q9NWW1

    Protein attributes for ZNFX1 Gene

    1918 amino acids
    Molecular mass:
    220227 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA91264.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA92642.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB14149.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB14696.1; Type=Erroneous termination; Positions=1846; Note=Translated as Trp.; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNFX1 Gene


neXtProt entry for ZNFX1 Gene

Post-translational modifications for ZNFX1 Gene

No data available for DME Specific Peptides for ZNFX1 Gene

Domains & Families for ZNFX1 Gene

Gene Families for ZNFX1 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNFX1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ZNFX1: view

No data available for UniProtKB/Swiss-Prot for ZNFX1 Gene

Function for ZNFX1 Gene

Phenotypes From GWAS Catalog for ZNFX1 Gene

Gene Ontology (GO) - Molecular Function for ZNFX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003700 DNA binding transcription factor activity IEA --
GO:0003723 RNA binding IDA,HDA 22658674
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNFX1: view
genes like me logo Genes that share phenotypes with ZNFX1: view

miRNA for ZNFX1 Gene

miRTarBase miRNAs that target ZNFX1

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNFX1 Gene

Localization for ZNFX1 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNFX1 gene
Compartment Confidence
mitochondrion 3
nucleus 3
cytosol 2
plasma membrane 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNFX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNFX1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ZNFX1 Gene

Pathways & Interactions for ZNFX1 Gene

SuperPathways for ZNFX1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNFX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNFX1: view

No data available for Pathways by source and SIGNOR curated interactions for ZNFX1 Gene

Drugs & Compounds for ZNFX1 Gene

No Compound Related Data Available

Transcripts for ZNFX1 Gene

Unigene Clusters for ZNFX1 Gene

Zinc finger, NFX1-type containing 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNFX1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c · 10d ^ 11 ^ 12 ^ 13 ^ 14 ^ 15
SP1: -
SP3: -
SP6: -
SP7: - -

Relevant External Links for ZNFX1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNFX1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNFX1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZNFX1 Gene

This gene is overexpressed in Heart (18.3), Adrenal (13.7), and Plasma (9.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZNFX1 Gene

Protein tissue co-expression partners for ZNFX1 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNFX1 Gene:


SOURCE GeneReport for Unigene cluster for ZNFX1 Gene:


mRNA Expression by UniProt/SwissProt for ZNFX1 Gene:

Tissue specificity: Widely expressed.

Evidence on tissue expression from TISSUES for ZNFX1 Gene

  • Nervous system(4.4)
  • Lung(2.7)
genes like me logo Genes that share expression patterns with ZNFX1: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNFX1 Gene

Orthologs for ZNFX1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ZNFX1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNFX1 33 34
  • 99.57 (n)
(Canis familiaris)
Mammalia ZNFX1 33 34
  • 89.93 (n)
(Bos Taurus)
Mammalia ZNFX1 33 34
  • 88.62 (n)
(Rattus norvegicus)
Mammalia Znfx1 33
  • 86.04 (n)
(Mus musculus)
Mammalia Znfx1 33 16 34
  • 85.98 (n)
(Monodelphis domestica)
Mammalia ZNFX1 34
  • 79 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 77 (a)
-- 34
  • 54 (a)
(Gallus gallus)
Aves ZNFX1 33 34
  • 67.95 (n)
(Anolis carolinensis)
Reptilia -- 34
  • 61 (a)
-- 34
  • 55 (a)
-- 34
  • 53 (a)
-- 34
  • 45 (a)
-- 34
  • 43 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100486840 33
  • 62.54 (n)
(Danio rerio)
Actinopterygii LOC100536767 33
  • 59.25 (n)
ZNFX1 34
  • 53 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006235 33
  • 47.76 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG6204 33 34
  • 45.61 (n)
(Caenorhabditis elegans)
Secernentea ZK1067.2 34
  • 22 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SEN1 34
  • 10 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 52 (a)
-- 34
  • 49 (a)
-- 34
  • 42 (a)
Species where no ortholog for ZNFX1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZNFX1 Gene

Gene Tree for ZNFX1 (if available)
Gene Tree for ZNFX1 (if available)

Paralogs for ZNFX1 Gene

Paralogs for ZNFX1 Gene

genes like me logo Genes that share paralogs with ZNFX1: view

Variants for ZNFX1 Gene

Sequence variations from dbSNP and Humsavar for ZNFX1 Gene

SNP ID Clin Chr 20 pos Variation AA Info Type
rs1000042643 -- 49,277,336(-) G/C genic_upstream_transcript_variant, intron_variant
rs1000070514 -- 49,279,695(-) T/C upstream_transcript_variant
rs1000085785 -- 49,274,637(-) T/C genic_upstream_transcript_variant, intron_variant
rs1000262921 -- 49,267,456(-) C/T intron_variant
rs1000314916 -- 49,250,983(-) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNFX1 Gene

Variant ID Type Subtype PubMed ID
dgv1248e212 CNV loss 25503493
esv1336829 CNV deletion 17803354
esv3445061 CNV duplication 20981092
nsv1064443 CNV gain 25217958
nsv1067146 CNV loss 25217958
nsv1072545 CNV deletion 25765185
nsv437839 CNV loss 16327808
nsv476410 CNV novel sequence insertion 20440878

Variation tolerance for ZNFX1 Gene

Residual Variation Intolerance Score: 11.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.49; 71.75% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNFX1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNFX1 Gene

Disorders for ZNFX1 Gene

Additional Disease Information for ZNFX1

No disorders were found for ZNFX1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNFX1 Gene

Publications for ZNFX1 Gene

  1. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10718198) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 2 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P … Rogers J (Nature 2001) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. A novel common variant in DCST2 is associated with length in early life and height in adulthood. (PMID: 25281659) van der Valk RJ … Early Growth Genetics (EGG) Consortium (Human molecular genetics 2015) 3 58

Products for ZNFX1 Gene

Sources for ZNFX1 Gene

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