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Aliases for ZNFX1 Gene

Aliases for ZNFX1 Gene

  • Zinc Finger, NFX1-Type Containing 1 2 3
  • KIAA1404 4

External Ids for ZNFX1 Gene

Previous GeneCards Identifiers for ZNFX1 Gene

  • GC20M047287
  • GC20M047296
  • GC20M047854
  • GC20M044611

Summaries for ZNFX1 Gene

GeneCards Summary for ZNFX1 Gene

ZNFX1 (Zinc Finger, NFX1-Type Containing 1) is a Protein Coding gene. An important paralog of this gene is SETX.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNFX1 Gene

Genomics for ZNFX1 Gene

Regulatory Elements for ZNFX1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ZNFX1 Gene

49,237,946 bp from pter
49,278,426 bp from pter
40,481 bases
Minus strand

Genomic View for ZNFX1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNFX1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNFX1 Gene

Proteins for ZNFX1 Gene

  • Protein details for ZNFX1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    NFX1-type zinc finger-containing protein 1
    Protein Accession:
    Secondary Accessions:
    • Q9BQM7
    • Q9BQM8
    • Q9H8C1
    • Q9H9S2
    • Q9NUM1
    • Q9NWW1

    Protein attributes for ZNFX1 Gene

    1918 amino acids
    Molecular mass:
    220227 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA91264.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA92642.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB14149.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB14696.1; Type=Erroneous termination; Positions=1846; Note=Translated as Trp.; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNFX1 Gene


neXtProt entry for ZNFX1 Gene

Proteomics data for ZNFX1 Gene at MOPED

Post-translational modifications for ZNFX1 Gene

  • Ubiquitination at Lys544 and Lys1665
  • Modification sites at PhosphoSitePlus

Other Protein References for ZNFX1 Gene

No data available for DME Specific Peptides for ZNFX1 Gene

Domains for ZNFX1 Gene

Protein Domains for ZNFX1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 6 NF-X1-type zinc fingers.
  • Contains 6 NF-X1-type zinc fingers.
genes like me logo Genes that share domains with ZNFX1: view

No data available for Gene Families for ZNFX1 Gene

Function for ZNFX1 Gene

Gene Ontology (GO) - Molecular Function for ZNFX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding --
GO:0003700 sequence-specific DNA binding transcription factor activity --
GO:0005488 binding --
GO:0005524 ATP binding --
GO:0008270 zinc ion binding --
genes like me logo Genes that share ontologies with ZNFX1: view

Animal Model Products

miRNA for ZNFX1 Gene

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNFX1

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNFX1 Gene

Localization for ZNFX1 Gene

Subcellular locations from

Jensen Localization Image for ZNFX1 Gene COMPARTMENTS Subcellular localization image for ZNFX1 gene
Compartment Confidence
cytosol 2
nucleus 2
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for ZNFX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
genes like me logo Genes that share ontologies with ZNFX1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ZNFX1 Gene

Pathways for ZNFX1 Gene

SuperPathways for ZNFX1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNFX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated --
genes like me logo Genes that share ontologies with ZNFX1: view

No data available for Pathways by source for ZNFX1 Gene

Transcripts for ZNFX1 Gene

Unigene Clusters for ZNFX1 Gene

Zinc finger, NFX1-type containing 1:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNFX1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNFX1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c · 10d ^ 11 ^ 12 ^ 13 ^ 14 ^ 15
SP1: -
SP3: -
SP6: -
SP7: - -

Relevant External Links for ZNFX1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNFX1 Gene

mRNA expression in normal human tissues for ZNFX1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for ZNFX1 Gene

This gene is overexpressed in Heart (18.3), Adrenal (13.7), and Plasma (9.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZNFX1 Gene

SOURCE GeneReport for Unigene cluster for ZNFX1 Gene Hs.371794

mRNA Expression by UniProt/SwissProt for ZNFX1 Gene

Tissue specificity: Widely expressed
genes like me logo Genes that share expressions with ZNFX1: view

Expression partners for ZNFX1 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for ZNFX1 Gene

Orthologs for ZNFX1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ZNFX1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ZNFX1 35
  • 88.62 (n)
  • 89.04 (a)
ZNFX1 36
  • 89 (a)
(Canis familiaris)
Mammalia ZNFX1 35
  • 89.93 (n)
  • 91.18 (a)
ZNFX1 36
  • 91 (a)
(Mus musculus)
Mammalia Znfx1 35
  • 85.98 (n)
  • 88.06 (a)
Znfx1 16
Znfx1 36
  • 88 (a)
(Pan troglodytes)
Mammalia ZNFX1 35
  • 99.57 (n)
  • 99.74 (a)
ZNFX1 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Znfx1 35
  • 86.04 (n)
  • 87.61 (a)
(Monodelphis domestica)
Mammalia ZNFX1 36
  • 79 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 77 (a)
-- 36
  • 54 (a)
(Gallus gallus)
Aves ZNFX1 35
  • 67.95 (n)
  • 68.38 (a)
ZNFX1 36
  • 62 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 45 (a)
-- 36
  • 43 (a)
-- 36
  • 53 (a)
-- 36
  • 61 (a)
-- 36
  • 55 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100486840 35
  • 62.54 (n)
  • 61.86 (a)
(Danio rerio)
Actinopterygii LOC100536767 35
  • 59.25 (n)
  • 56.79 (a)
ZNFX1 36
  • 53 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006235 35
  • 47.76 (n)
  • 37.95 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG6204 35
  • 45.61 (n)
  • 36.67 (a)
CG6204 36
  • 30 (a)
(Caenorhabditis elegans)
Secernentea ZK1067.2 36
  • 22 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SEN1 36
  • 10 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 42 (a)
-- 36
  • 49 (a)
-- 36
  • 52 (a)
Species with no ortholog for ZNFX1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZNFX1 Gene

Gene Tree for ZNFX1 (if available)
Gene Tree for ZNFX1 (if available)

Paralogs for ZNFX1 Gene

Paralogs for ZNFX1 Gene

genes like me logo Genes that share paralogs with ZNFX1: view

Variants for ZNFX1 Gene

Sequence variations from dbSNP and Humsavar for ZNFX1 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs3021 -- 49,257,468(+) CCACA(A/G/T)TGGTC missense, synonymous-codon, reference
rs7689 -- 49,245,913(-) AAAAC(A/G)ATGAT utr-variant-3-prime
rs57950 -- 49,270,147(+) AAGTC(A/G)TATCT reference, synonymous-codon
rs171131 -- 49,250,491(-) ttttt(A/T)aaaat intron-variant
rs171132 -- 49,258,902(-) ggtct(C/T)gagct intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNFX1 Gene

Variant ID Type Subtype PubMed ID
esv1336829 CNV Deletion 17803354
nsv437839 CNV Loss 16327808

Relevant External Links for ZNFX1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNFX1 Gene

Disorders for ZNFX1 Gene

No disorders were found for ZNFX1 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for ZNFX1 Gene

Publications for ZNFX1 Gene

  1. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10718198) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4
  2. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Antigen-specific IgG elicited in subjects with prostate cancer treated with flt3 ligand. (PMID: 15838384) Dunphy E.J. … McNeel D.G. (J. Immunother. 2005) 3
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for ZNFX1 Gene

Sources for ZNFX1 Gene

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