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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZNF98 Gene

protein-coding   GIFtS: 39
GCID: GC19M022573

Zinc Finger Protein 98

  Search for ZNF98
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Zinc Finger Protein 981 2
Zinc Finger Protein 7391 2 3
Zinc Finger Protein F71752 3
ZNF7392 3
F71752

External Ids:    HGNC: 131741   Entrez Gene: 1481982   Ensembl: ENSG000001973607   OMIM: 6039805   UniProtKB: A6NK753   

Export aliases for ZNF98 gene to outside databases

Previous GC identifers: GC19U990118 GC19M022365 GC19P022354


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ZNF98 Gene: 
ZNF98 (zinc finger protein 98) is a protein-coding gene. GO annotations related to this gene include DNA binding and zinc ion binding. An important paralog of this gene is ZNF85.

UniProtKB/Swiss-Prot: ZNF98_HUMAN, A6NK75
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.2  NT_011295.11  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZNF98 gene promoter:
         NF-AT4   NF-AT2   NF-AT3   Evi-1   NF-AT1   NF-AT   GATA-1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for ZNF98

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF98


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p12   Ensembl cytogenetic band:  19p12   HGNC cytogenetic band: 19p12

ZNF98 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF98 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M022573:  view genomic region     (about GC identifiers)

Start:
22,573,821 bp from pter      End:
22,715,287 bp from pter
Size:
141,467 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZNF98_HUMAN, A6NK75 (See protein sequence)
Recommended Name: Zinc finger protein 98  
Size: 572 amino acids; 65799 Da
Subcellular location: Nucleus (Probable)
Sequence caution: Sequence=AAI10577.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAI29811.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

Explore the universe of human proteins at neXtProt for ZNF98: NX_A6NK75

Explore proteomics data for ZNF98 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_A6NK75

  • ZNF98 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ZNF98 Protein Expression
    REFSEQ proteins: NP_001092096.1  
    ENSEMBL proteins: 
     ENSP00000350418   ENSP00000470736   ENSP00000470558   ENSP00000472301  

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    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--

    ZNF98 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR001909 Krueppel-associated_box
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry A6NK75

    ProtoNet protein and cluster: A6NK75

    UniProtKB/Swiss-Prot: ZNF98_HUMAN, A6NK75
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 13 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    ZNF98 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZNF98_HUMAN, A6NK75
    Function: May be involved in transcriptional regulation

         Genatlas biochemistry entry for ZNF98:
    zinc finger protein 98,KRAB subfamily

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0008270zinc ion binding ----
    GO:0046872metal ion binding IEA--
         
    ZNF98 for ontologies           About GeneDecksing


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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF98

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--

    ZNF98 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZNF98

    Search CenterWatch for drugs/clinical trials and news about ZNF98

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    About This Section

    REFSEQ mRNAs for ZNF98 gene: 
    NM_001098626.1  

    Unigene Cluster for ZNF98:

    Zinc finger protein 98
    Hs.667355  [show with all ESTs]
    Unigene Representative Sequence: NM_001098626
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000357774(uc002nqt.2) ENST00000593657 ENST00000601553 ENST00000593802
    ENST00000599879
    miRNA
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    Additional mRNA sequence: 

    BC110576.1 BC129810.1 

    2 DOTS entries:

    DT.91930341  DT.75112103 

    2 AceView cDNA sequences:

    BG286866 AI652968 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZNF98 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ZNF98 Expression
    About this image


    See ZNF98 Protein Expression from SPIRE MOPED and PaxDB
    SOURCE GeneReport for Unigene cluster: Hs.667355
        SABiosciences Custom PCR Arrays for ZNF98
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF98

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for ZNF98 gene from 1/4 species (see all 4)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    26(a)
    1 → many
    GL343733.1(125230-159240)
            Species with no ortholog for ZNF98

    ENSEMBL Gene Tree for ZNF98 (if available)
    TreeFam Gene Tree for ZNF98 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZNF98 gene
    ZNF4921 2  ZNF852  ZNF4862  ZNF1952  ZNF7272  ZNF922  ZNF1002  ZNF7322  
    ZNF6752  ZNF1382  ZNF5062  ZNF662  ZNF2732  ZNF6952  ZNF6262  ZNF6802  
    ZNF4792  ZNF2532  ZNF6822  ZNF6762  ZNF6812  ZNF1412  ZNF7362  ZNF6792  
    ZNF2572  ZNF2672  ZNF2542  ZNF7372  ZNF7162  ZNF7142  ZNF5192  ZNF4302  
    ZNF7302  ZNF7082  ZNF1172  ZNF4312  ZNF902  ZNF7262  ZNF7282  
    18/517 SIMAP similar genes for ZNF98 using alignment to 4 protein entries:     ZNF98_HUMAN (see all proteins) (see all similar genes):
    ZNF492    MGC12518    ZNF724P    ZNF273    ZNF430    ZNF675
    ZNF506    ZNF730    ZNF66    ZNF90    ZNF100    ZNF737
    ZNF726    ZNF818P    ZNF493    ZNF254    ZNF429    ZNF257

    ZNF98 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/786 SNPs in ZNF98 are shown (see all 786)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1426583521,2
    C--22573484(+) TAATT-/ACAACATT 1 -- cds10--------
    rs2005339911,2
    C--22573509(+) ATTTG-/ACAGTTA 1 -- ds50010--------
    rs104180431,2
    C,F,H--22573521(+) TTTACT/ATTTAA 1 -- ds50015Minor allele frequency- A:0.03NS EA WA 524
    rs18976131,2
    C,F,A,H--22573575(-) AGATTT/CTTTGG 1 -- ds50016Minor allele frequency- C:0.47NS EA WA NA 422
    rs1506817291,2
    C--22573673(+) AAAGTA/CTGAAG 1 -- ds50010--------
    rs1453145471,2
    C--22573710(+) TAAAT-/TCTCTGA 1 -- ds50010--------
    rs1479541201,2
    --22573838(+) TCTAAA/GTTTAT 1 -- ds50010--------
    rs1884202101,2
    --22574094(+) TCTCTA/GATGCT 1 -- ut310--------
    rs1931971611,2
    --22574156(+) ACATTC/TGTTCT 1 -- ut310--------
    rs104185991,2
    C--22574278(+) CCAGTC/GTGATA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for ZNF98 (22573821 - 22715287 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/20 variations for ZNF98 (see all 20):    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv552e201CNV Deletion23290073
    esv2718335CNV Deletion23290073
    dgv553e201CNV Deletion23290073
    esv1314456CNV Deletion17803354
    dgv633e199CNV Deletion23128226
    nsv436853CNV Insertion17901297
    nsv911446CNV Loss21882294
    esv34340CNV Loss17911159
    nsv911447CNV Loss21882294
    nsv911441CNV Gain21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ZNF98 for disorders           About MalaCards
    OMIM gene information: 603980    OMIM disorders: --


    ZNF98 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ZNF98

    Export disorders for ZNF98 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZNF98 gene, integrated from 9 sources (see all 15):
    (articles sorted by number of sources associating them with ZNF98)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genetic determinants of statin-induced low-density lip oprotein cholesterol reduction: the Justification for the Use of Statins in Prev ention: an Intervention Trial Evaluating Rosuvastatin (JUPITER) trial. (PubMed id 22331829)1, 4 Chasman D.I....Ridker P.M. (2012)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (2004)
    4. Clustered organization of homologous KRAB zinc-finger genes with enhanced expression in human T lymphoid cells. (PubMed id 8467795)1, 2 Bellefroid E.J.... Martial J.A. (1993)
    5. GWAS of dental caries patterns in the permanent dentit ion. (PubMed id 23064961)1 Shaffer J.R....Marazita M.L. (2013)
    6. A genome-wide association study identifies a potential novel gene locus for keratoconus, one of the commonest causes for corneal trans plantation in developed countries. (PubMed id 21979947)4 Li X....Rabinowitz Y.S. (2012)
    7. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    8. Genome-wide association scan of dental caries in the p ermanent dentition. (PubMed id 23259602)1 Wang X....Marazita M.L. (2012)
    9. Genome-wide association identifies OBFC1 as a locus i nvolved in human leukocyte telomere biology. (PubMed id 20421499)4 Levy D....Aviv A. (2010)
    10. Framingham Heart Study 100K Project: genome-wide associations for blood pressure and arterial stiffness. (PubMed id 17903302)4 Levy D....Mitchell G.F. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 148198 HGNC: 13174 AceView: LOC148198.1 Ensembl:ENSG00000197360 euGenes: HUgn148198
    ECgene: ZNF98 H-InvDB: ZNF98

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZNF98 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZNF98 gene:
    Search GeneIP for patents involving ZNF98

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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