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Aliases for ZNF98 Gene

Aliases for ZNF98 Gene

  • Zinc Finger Protein 98 2 3
  • Zinc Finger Protein 739 2 3 4
  • Zinc Finger Protein F7175 3 4
  • ZNF739 3 4
  • F7175 3

External Ids for ZNF98 Gene

Previous GeneCards Identifiers for ZNF98 Gene

  • GC19U990118
  • GC19M022365
  • GC19M022573
  • GC19P022354

Summaries for ZNF98 Gene

GeneCards Summary for ZNF98 Gene

ZNF98 (Zinc Finger Protein 98) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF253.

UniProtKB/Swiss-Prot for ZNF98 Gene

  • May be involved in transcriptional regulation

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF98 Gene

Genomics for ZNF98 Gene

Regulatory Elements for ZNF98 Gene

Genomic Location for ZNF98 Gene

Chromosome:
19
Start:
22,391,011 bp from pter
End:
22,532,485 bp from pter
Size:
141,475 bases
Orientation:
Minus strand

Genomic View for ZNF98 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF98 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF98 Gene

Proteins for ZNF98 Gene

  • Protein details for ZNF98 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NK75-ZNF98_HUMAN
    Recommended name:
    Zinc finger protein 98
    Protein Accession:
    A6NK75

    Protein attributes for ZNF98 Gene

    Size:
    572 amino acids
    Molecular mass:
    65799 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAI10577.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAI29811.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for ZNF98 Gene

Proteomics data for ZNF98 Gene at MOPED

Post-translational modifications for ZNF98 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF98 Gene

No data available for DME Specific Peptides for ZNF98 Gene

Domains & Families for ZNF98 Gene

Gene Families for ZNF98 Gene

Protein Domains for ZNF98 Gene

Suggested Antigen Peptide Sequences for ZNF98 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A6NK75

UniProtKB/Swiss-Prot:

ZNF98_HUMAN :
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 13 C2H2-type zinc fingers.
Domain:
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 13 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF98: view

Function for ZNF98 Gene

Molecular function for ZNF98 Gene

GENATLAS Biochemistry:
zinc finger protein 98,KRAB subfamily
UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation

Gene Ontology (GO) - Molecular Function for ZNF98 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IBA --
GO:0003676 nucleic acid binding --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF98: view

Phenotypes for ZNF98 Gene

GenomeRNAi human phenotypes for ZNF98:
genes like me logo Genes that share phenotypes with ZNF98: view

Animal Model Products

CRISPR Products

miRNA for ZNF98 Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF98

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF98 Gene

Localization for ZNF98 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF98 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF98 Gene COMPARTMENTS Subcellular localization image for ZNF98 gene
Compartment Confidence
nucleus 3

Gene Ontology (GO) - Cellular Components for ZNF98 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IBA --
genes like me logo Genes that share ontologies with ZNF98: view

Pathways & Interactions for ZNF98 Gene

SuperPathways for ZNF98 Gene

No Data Available

Interacting Proteins for ZNF98 Gene

Gene Ontology (GO) - Biological Process for ZNF98 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA --
genes like me logo Genes that share ontologies with ZNF98: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF98 Gene

Drugs & Compounds for ZNF98 Gene

No Compound Related Data Available

Transcripts for ZNF98 Gene

mRNA/cDNA for ZNF98 Gene

(3) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF98 Gene

Zinc finger protein 98:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF98

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF98 Gene

No ASD Table

Relevant External Links for ZNF98 Gene

GeneLoc Exon Structure for
ZNF98
ECgene alternative splicing isoforms for
ZNF98

Expression for ZNF98 Gene

mRNA expression in normal human tissues for ZNF98 Gene

mRNA differential expression in normal tissues according to GTEx for ZNF98 Gene

This gene is overexpressed in Pancreas (x10.0), Testis (x5.8), and Brain - Caudate (basal ganglia) (x4.0).

SOURCE GeneReport for Unigene cluster for ZNF98 Gene Hs.667355

genes like me logo Genes that share expression patterns with ZNF98: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for ZNF98 Gene

Orthologs for ZNF98 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF98 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC100611724 35
  • 95.5 (n)
  • 91.54 (a)
-- 36
  • 97 (a)
OneToMany
cow
(Bos Taurus)
Mammalia -- 36
  • 57 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 40 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 41 (a)
ManyToMany
-- 36
  • 51 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Zfp71-rs1 36
  • 59 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 55 (a)
ManyToMany
-- 36
  • 36 (a)
ManyToMany
-- 36
  • 43 (a)
ManyToMany
-- 36
  • 41 (a)
ManyToMany
-- 36
  • 33 (a)
ManyToMany
-- 36
  • 32 (a)
ManyToMany
-- 36
  • 32 (a)
ManyToMany
-- 36
  • 30 (a)
ManyToMany
Species with no ortholog for ZNF98:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF98 Gene

ENSEMBL:
Gene Tree for ZNF98 (if available)
TreeFam:
Gene Tree for ZNF98 (if available)

Paralogs for ZNF98 Gene

(518) SIMAP similar genes for ZNF98 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ZNF98: view

Variants for ZNF98 Gene

Sequence variations from dbSNP and Humsavar for ZNF98 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs1368476 -- 22,403,390(-) GTCTT(C/T)GTGGG synonymous-codon, reference, intron-variant
rs1368477 -- 22,403,207(-) tttga(C/T)ctgaa intron-variant
rs1821294 -- 22,403,264(-) ttttt(G/T)ttttt intron-variant
rs1835995 -- 22,401,445(-) ttatt(A/T)ttgtc intron-variant
rs1897612 -- 22,403,674(-) AGAAT(A/G)CATTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF98 Gene

Variant ID Type Subtype PubMed ID
esv4924 CNV Complex 18987735
esv2718335 CNV Deletion 23290073
dgv552e201 CNV Deletion 23290073
dgv1066e1 CNV Complex 17122850
esv731 CNV CNV 17122850
esv34340 CNV Loss 17911159
dgv553e201 CNV Deletion 23290073
dgv633e199 CNV Deletion 23128226
nsv436853 CNV Insertion 17901297
nsv525240 CNV Gain 19592680
dgv3813n71 CNV Gain 21882294
dgv3814n71 CNV Gain 21882294
dgv3n43 CNV Gain 19587683
nsv911441 CNV Gain 21882294
essv3682 CNV CNV 17122850
nsv911446 CNV Loss 21882294
dgv1067e1 CNV Complex 17122850
nsv911447 CNV Loss 21882294
esv2751784 CNV Gain 17911159
esv1314456 CNV Deletion 17803354

Variation tolerance for ZNF98 Gene

Residual Variation Intolerance Score: 87.86% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.04; 50.31% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF98 Gene

HapMap Linkage Disequilibrium report
ZNF98

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF98 Gene

Disorders for ZNF98 Gene

Relevant External Links for ZNF98

Genetic Association Database (GAD)
ZNF98
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF98
genes like me logo Genes that share disorders with ZNF98: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF98 Gene

Publications for ZNF98 Gene

  1. GWAS of dental caries patterns in the permanent dentition. (PMID: 23064961) Shaffer J.R. … Marazita M.L. (J. Dent. Res. 2013) 67
  2. Genetic determinants of statin-induced low-density lipoprotein cholesterol reduction: the Justification for the Use of Statins in Prevention: an Intervention Trial Evaluating Rosuvastatin (JUPITER) trial. (PMID: 22331829) Chasman D.I. … Ridker P.M. (Circ Cardiovasc Genet 2012) 67
  3. A genome-wide association study identifies a potential novel gene locus for keratoconus, one of the commonest causes for corneal transplantation in developed countries. (PMID: 21979947) Li X. … Rabinowitz Y.S. (Hum. Mol. Genet. 2012) 67
  4. Genome-wide association scan of dental caries in the permanent dentition. (PMID: 23259602) Wang X. … Marazita M.L. (BMC Oral Health 2012) 67
  5. Genome-wide association identifies OBFC1 as a locus involved in human leukocyte telomere biology. (PMID: 20421499) Levy D. … Aviv A. (Proc. Natl. Acad. Sci. U.S.A. 2010) 67

Products for ZNF98 Gene

Sources for ZNF98 Gene

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