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Aliases for ZNF93 Gene

Aliases for ZNF93 Gene

  • Zinc Finger Protein 93 2 3 5
  • Zinc Finger Protein 505 2 3 4
  • Zinc Finger Protein HTF34 3 4
  • ZNF505 3 4
  • Zinc Finger Protein 93 (HTF34) 2
  • HPF34 3
  • HTF34 3
  • TF34 3

External Ids for ZNF93 Gene

Previous HGNC Symbols for ZNF93 Gene

  • ZNF505

Previous GeneCards Identifiers for ZNF93 Gene

  • GC19U990113
  • GC19M020417
  • GC19P019871
  • GC19P019887
  • GC19P019805
  • GC19P019873
  • GC19P019979
  • GC19P020012

Summaries for ZNF93 Gene

GeneCards Summary for ZNF93 Gene

ZNF93 (Zinc Finger Protein 93) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZNF66.

UniProtKB/Swiss-Prot for ZNF93 Gene

  • Transcription factor specifically required to repress long interspersed nuclear element 1 (L1) retrotransposons: recognizes and binds L1 sequences and repress their expression by recruiting a repressive complex containing TRIM28/KAP1 (PubMed:25274305). Not able to repress expression of all subtypes of L1 elements. Binds to the 5 end of L1PA4, L1PA5 and L1PA6 subtypes, and some L1PA3 subtypes. Does not bind to L1PA7 or older subtypes nor at the most recently evolved L1PA2 and L1Hs. 50% of L1PA3 elements have lost the ZNF93-binding site, explaining why ZNF93 is not able to repress their expression (PubMed:25274305).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF93 Gene

Genomics for ZNF93 Gene

Regulatory Elements for ZNF93 Gene

Enhancers for ZNF93 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F019865 1.6 FANTOM5 Ensembl ENCODE 20.2 -34.1 -34107 3.2 ATF1 PKNOX1 ARID4B SIN3A DMAP1 ZNF48 ETS1 YY1 GATA2 CBX5 ZNF93 ZNF506 GMIP ZNF14 LPAR2 PBX4 ZNF253 ENSG00000267268 ZNF101 ZNF682
GH19F019899 1 ENCODE 29.5 +0.2 246 3.0 ATF1 PKNOX1 SIN3A ZNF2 YY1 GTF3C2 ELK1 FOS YY2 NFYC ZNF93 ZNF506 ZNF66 ZNF90 ZNF101 ATP13A1 LOC101928960 BNIP3P24 ENSG00000267268 LOC102724360
GH19F019860 0.8 Ensembl ENCODE 17.9 -39.8 -39792 1.4 L3MBTL2 NFYA POLR2A NFYB FOS REST MGA ZNF93 ATP13A1 ZNF101 BNIP3P9 ZNF253
GH19F019374 1.4 Ensembl ENCODE 9.7 -524.0 -523961 4.5 PKNOX1 ARNT ZFP64 ARID4B SIN3A FEZF1 YY1 ZNF766 ZNF207 FOS ENSG00000268030 ZNF90 UPF1 ENSG00000267481 ENSG00000268938 ZNF253 ZNF506 ZNF14 GATAD2A ELL
GH19F019261 0.9 ENCODE 9.7 -639.1 -639098 0.5 HDAC1 ATF1 CREB3L1 NFRKB ZNF48 ZBTB40 ZNF766 CREM ZNF202 ZBTB2 ZNF90 ENSG00000268030 UPF1 ENSG00000267481 ZNF93 HAPLN4 ENSG00000280282
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF93 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF93 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001418417 387 2600 PKNOX1 SIN3A ZNF2 GTF3C2 ELK1 FOS YY2 NFYC REST CREB3

Genomic Location for ZNF93 Gene

Chromosome:
19
Start:
19,900,913 bp from pter
End:
19,935,998 bp from pter
Size:
35,086 bases
Orientation:
Plus strand

Genomic View for ZNF93 Gene

Genes around ZNF93 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF93 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF93 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF93 Gene

Proteins for ZNF93 Gene

  • Protein details for ZNF93 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P35789-ZNF93_HUMAN
    Recommended name:
    Zinc finger protein 93
    Protein Accession:
    P35789
    Secondary Accessions:
    • A6NMY2
    • B9EGT2
    • Q8N8Q4
    • Q9H9X5
    • Q9Y2N8

    Protein attributes for ZNF93 Gene

    Size:
    620 amino acids
    Molecular mass:
    70971 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Confers resistance to ET-743 (trabectedin, Yondelis) and PM00104 (Zalypsis), 2 marine derived compounds with antitumor activity in cancer cell lines.
    • ZNF93 is only present in primates and evolved to repress the primate L1 lineage until 12.5 million years. Evolution stopped when the L1PA3-subfamily of retrotransposons, that escape repression by ZNF93 through the removal of the ZNF93-binding site, appeared (PubMed:25274305).
    SequenceCaution:
    • Sequence=AAD22981.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=BAB14093.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF93 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF93 Gene

Post-translational modifications for ZNF93 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF93 Gene

No data available for DME Specific Peptides for ZNF93 Gene

Domains & Families for ZNF93 Gene

Gene Families for ZNF93 Gene

Suggested Antigen Peptide Sequences for ZNF93 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P35789

UniProtKB/Swiss-Prot:

ZNF93_HUMAN :
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 17 C2H2-type zinc fingers.
Domain:
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 17 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF93: view

Function for ZNF93 Gene

Molecular function for ZNF93 Gene

GENATLAS Biochemistry:
zinc finger protein 93 (HTF34),KRAB subfamily
UniProtKB/Swiss-Prot Function:
Transcription factor specifically required to repress long interspersed nuclear element 1 (L1) retrotransposons: recognizes and binds L1 sequences and repress their expression by recruiting a repressive complex containing TRIM28/KAP1 (PubMed:25274305). Not able to repress expression of all subtypes of L1 elements. Binds to the 5 end of L1PA4, L1PA5 and L1PA6 subtypes, and some L1PA3 subtypes. Does not bind to L1PA7 or older subtypes nor at the most recently evolved L1PA2 and L1Hs. 50% of L1PA3 elements have lost the ZNF93-binding site, explaining why ZNF93 is not able to repress their expression (PubMed:25274305).

Gene Ontology (GO) - Molecular Function for ZNF93 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding NAS 2023909
GO:0008270 zinc ion binding NAS 2023909
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF93: view
genes like me logo Genes that share phenotypes with ZNF93: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF93 Gene

Localization for ZNF93 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF93 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF93 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF93 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF93: view

Pathways & Interactions for ZNF93 Gene

SuperPathways for ZNF93 Gene

No Data Available

Interacting Proteins for ZNF93 Gene

Gene Ontology (GO) - Biological Process for ZNF93 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0045892 negative regulation of transcription, DNA-templated IDA 25274305
GO:0070895 negative regulation of transposon integration IDA 25274305
genes like me logo Genes that share ontologies with ZNF93: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF93 Gene

Transcripts for ZNF93 Gene

Unigene Clusters for ZNF93 Gene

Zinc finger protein 93:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF93 Gene

No ASD Table

Relevant External Links for ZNF93 Gene

GeneLoc Exon Structure for
ZNF93
ECgene alternative splicing isoforms for
ZNF93

Expression for ZNF93 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF93 Gene

Protein differential expression in normal tissues from HIPED for ZNF93 Gene

This gene is overexpressed in Liver (42.0) and Lymph node (27.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF93 Gene



Protein tissue co-expression partners for ZNF93 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF93 Gene:

ZNF93

SOURCE GeneReport for Unigene cluster for ZNF93 Gene:

Hs.301059
genes like me logo Genes that share expression patterns with ZNF93: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF93 Gene

Orthologs for ZNF93 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF93 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF93 34
  • 95.86 (n)
mouse
(Mus musculus)
Mammalia Zfp457 34 16
  • 65.73 (n)
Zfp386 35
  • 37 (a)
OneToMany
cow
(Bos Taurus)
Mammalia -- 35
  • 57 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 52 (a)
ManyToMany
-- 35
  • 40 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 35
  • 40 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 55 (a)
ManyToMany
-- 35
  • 46 (a)
ManyToMany
-- 35
  • 42 (a)
ManyToMany
-- 35
  • 37 (a)
ManyToMany
-- 35
  • 35 (a)
ManyToMany
-- 35
  • 35 (a)
ManyToMany
-- 35
  • 34 (a)
ManyToMany
-- 35
  • 31 (a)
ManyToMany
Species where no ortholog for ZNF93 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF93 Gene

ENSEMBL:
Gene Tree for ZNF93 (if available)
TreeFam:
Gene Tree for ZNF93 (if available)

Paralogs for ZNF93 Gene

(526) SIMAP similar genes for ZNF93 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with ZNF93: view

Variants for ZNF93 Gene

Sequence variations from dbSNP and Humsavar for ZNF93 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10401345 -- 19,934,077(+) GAATG(C/T)GGCAA reference, synonymous-codon
rs10401486 -- 19,899,192(+) tcaaa(C/T)agctg upstream-variant-2KB
rs10406758 -- 19,920,890(+) aaaac(C/T)agctc intron-variant
rs10407726 -- 19,900,209(+) aactt(G/T)cttgt upstream-variant-2KB
rs10407807 -- 19,935,293(+) CAAGC(A/C)AGCTA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ZNF93 Gene

Variant ID Type Subtype PubMed ID
nsv961192 CNV duplication 23825009
nsv578800 CNV gain 21841781
nsv519535 CNV gain 19592680
nsv458376 CNV gain 19166990
nsv1061846 CNV loss 25217958
esv3893169 CNV loss 25118596
esv3643861 CNV gain 21293372
esv3556152 CNV deletion 23714750
esv2718301 CNV deletion 23290073
esv2718300 CNV deletion 23290073
esv2718298 CNV deletion 23290073
esv2718296 CNV deletion 23290073
esv2656893 CNV deletion 23128226
dgv509e201 CNV deletion 23290073
dgv3456n100 CNV gain 25217958

Variation tolerance for ZNF93 Gene

Residual Variation Intolerance Score: 89.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.86; 83.64% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF93 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF93

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF93 Gene

Disorders for ZNF93 Gene

Relevant External Links for ZNF93

Genetic Association Database (GAD)
ZNF93
Human Genome Epidemiology (HuGE) Navigator
ZNF93
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF93

No disorders were found for ZNF93 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF93 Gene

Publications for ZNF93 Gene

  1. The evolutionarily conserved Kruppel-associated box domain defines a subfamily of eukaryotic multifingered proteins. (PMID: 2023909) Bellefroid E.J. … Martial J.A. (Proc. Natl. Acad. Sci. U.S.A. 1991) 2 3 4 64
  2. An evolutionary arms race between KRAB zinc-finger genes ZNF91/93 and SVA/L1 retrotransposons. (PMID: 25274305) Jacobs F.M. … Haussler D. (Nature 2014) 3 4 64
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  4. Genome-wide and candidate gene association study of cigarette smoking behaviors. (PMID: 19247474) Caporaso N. … Bergen A.W. (PLoS ONE 2009) 3 46 64
  5. ZNF93 increases resistance to ET-743 (Trabectedin; Yondelis) and PM00104 (Zalypsis) in human cancer cell lines. (PMID: 19742314) Duan Z. … Hornicek F.J. (PLoS ONE 2009) 3 4 64

Products for ZNF93 Gene

Sources for ZNF93 Gene

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