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Aliases for ZNF93 Gene

Aliases for ZNF93 Gene

  • Zinc Finger Protein 93 2 3
  • Zinc Finger Protein 505 2 3 4
  • Zinc Finger Protein HTF34 3 4
  • ZNF505 3 4
  • Zinc Finger Protein 93 (HTF34) 2
  • HPF34 3
  • HTF34 3
  • TF34 3

External Ids for ZNF93 Gene

Previous Symbols for ZNF93 Gene

  • ZNF505

Summaries for ZNF93 Gene

GeneCards Summary for ZNF93 Gene

ZNF93 (Zinc Finger Protein 93) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ZNF253.

UniProtKB/Swiss-Prot for ZNF93 Gene

  • Transcription factor specifically required to repress long interspersed nuclear element 1 (L1) retrotransposons: recognizes and binds L1 sequences and repress their expression by recruiting a repressive complex containing TRIM28/KAP1 (PubMed:25274305). Not able to repress expression of all subtypes of L1 elements. Binds to the 5 end of L1PA4, L1PA5 and L1PA6 subtypes, and some L1PA3 subtypes. Does not bind to L1PA7 or older subtypes nor at the most recently evolved L1PA2 and L1Hs. 50% of L1PA3 elements have lost the ZNF93-binding site, explaining why ZNF93 is not able to repress their expression (PubMed:25274305).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF93 Gene

Genomics for ZNF93 Gene

Genomic Location for ZNF93 Gene

Start:
19,900,913 bp from pter
End:
19,935,575 bp from pter
Size:
34,663 bases
Orientation:
Plus strand

Genomic View for ZNF93 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF93 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF93 Gene

Regulatory Elements for ZNF93 Gene

Proteins for ZNF93 Gene

  • Protein details for ZNF93 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P35789-ZNF93_HUMAN
    Recommended name:
    Zinc finger protein 93
    Protein Accession:
    P35789
    Secondary Accessions:
    • A6NMY2
    • B9EGT2
    • Q8N8Q4
    • Q9H9X5
    • Q9Y2N8

    Protein attributes for ZNF93 Gene

    Size:
    620 amino acids
    Molecular mass:
    70971 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Confers resistance to ET-743 (trabectedin, Yondelis) and PM00104 (Zalypsis), 2 marine derived compounds with antitumor activity in cancer cell lines.
    • ZNF93 is only present in primates and evolved to repress the primate L1 lineage until 12.5 million years. Evolution stopped when the L1PA3-subfamily of retrotransposons, that escape repression by ZNF93 through the removal of the ZNF93-binding site, appeared (PubMed:25274305).
    SequenceCaution:
    • Sequence=AAD22981.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=BAB14093.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF93 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF93 Gene

Proteomics data for ZNF93 Gene at MOPED

Post-translational modifications for ZNF93 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys97

Other Protein References for ZNF93 Gene

No data available for DME Specific Peptides for ZNF93 Gene

Domains for ZNF93 Gene

Gene Families for ZNF93 Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type

UniProtKB/Swiss-Prot:

ZNF93_HUMAN
Domain:
  • Contains 1 KRAB domain.:
    • P35789
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.:
    • P35789
Similarity:
  • Contains 17 C2H2-type zinc fingers.:
    • P35789
genes like me logo Genes that share domains with ZNF93: view

Function for ZNF93 Gene

Molecular function for ZNF93 Gene

GENATLAS Biochemistry: zinc finger protein 93 (HTF34),KRAB subfamily
UniProtKB/Swiss-Prot Function: Transcription factor specifically required to repress long interspersed nuclear element 1 (L1) retrotransposons: recognizes and binds L1 sequences and repress their expression by recruiting a repressive complex containing TRIM28/KAP1 (PubMed:25274305). Not able to repress expression of all subtypes of L1 elements. Binds to the 5 end of L1PA4, L1PA5 and L1PA6 subtypes, and some L1PA3 subtypes. Does not bind to L1PA7 or older subtypes nor at the most recently evolved L1PA2 and L1Hs. 50% of L1PA3 elements have lost the ZNF93-binding site, explaining why ZNF93 is not able to repress their expression (PubMed:25274305).

Gene Ontology (GO) - Molecular Function for ZNF93 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0003700 sequence-specific DNA binding transcription factor activity NAS 2023909
GO:0008270 zinc ion binding NAS 2023909
GO:0046872 metal ion binding --
genes like me logo Genes that share ontologies with ZNF93: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ZNF93 Gene

Localization for ZNF93 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF93 Gene

Gene Ontology (GO) - Cellular Components for ZNF93 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF93: view

Pathways for ZNF93 Gene

SuperPathways for ZNF93 Gene

No Data Available

Interacting Proteins for ZNF93 Gene

Gene Ontology (GO) - Biological Process for ZNF93 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA --
GO:0045892 negative regulation of transcription, DNA-templated IDA 25274305
GO:0070895 negative regulation of transposon integration IDA 25274305
genes like me logo Genes that share ontologies with ZNF93: view

No data available for Pathways by source for ZNF93 Gene

Transcripts for ZNF93 Gene

Unigene Clusters for ZNF93 Gene

Zinc finger protein 93:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF93 Gene

No ASD Table

Relevant External Links for ZNF93 Gene

GeneLoc Exon Structure for
ZNF93
ECgene alternative splicing isoforms for
ZNF93

Expression for ZNF93 Gene

mRNA expression in normal human tissues for ZNF93 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ZNF93 Gene

SOURCE GeneReport for Unigene cluster for ZNF93 Gene Hs.301059

genes like me logo Genes that share expressions with ZNF93: view

Orthologs for ZNF93 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF93 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF93 36
  • 95.86 (n)
  • 95.48 (a)
cow
(Bos Taurus)
Mammalia -- 37
  • 57 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 37
  • 40 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Zfp386 37
  • 37 (a)
OneToMany
Zfp457 36
  • 65.73 (n)
  • 56.44 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 40 (a)
ManyToMany
-- 37
  • 52 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 55 (a)
ManyToMany
-- 37
  • 37 (a)
ManyToMany
-- 37
  • 46 (a)
ManyToMany
-- 37
  • 42 (a)
ManyToMany
-- 37
  • 35 (a)
ManyToMany
-- 37
  • 35 (a)
ManyToMany
-- 37
  • 34 (a)
ManyToMany
-- 37
  • 31 (a)
ManyToMany
Species with no ortholog for ZNF93:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF93 Gene

ENSEMBL:
Gene Tree for ZNF93 (if available)
TreeFam:
Gene Tree for ZNF93 (if available)

Paralogs for ZNF93 Gene

Selected SIMAP similar genes for ZNF93 Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for ZNF93 Gene

genes like me logo Genes that share paralogs with ZNF93: view

Variants for ZNF93 Gene

Sequence variations from dbSNP and Humsavar for ZNF93 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs11786 -- 19,935,409(-) AGAAG(A/G)TAAAG utr-variant-3-prime
rs1048421 -- 19,935,338(+) GACCA(A/G)GCTAA utr-variant-3-prime
rs1303719 -- 19,906,581(+) CGTAG(C/T)TTCAT intron-variant
rs2110589 -- 19,899,008(+) ggaac(A/G)gcact upstream-variant-2KB
rs2192622 -- 19,898,930(+) AGTCT(G/T)CCCTT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ZNF93 Gene

Variant ID Type Subtype PubMed ID
dgv3791n71 CNV Loss 21882294
nsv519535 CNV Gain 19592680
esv2718296 CNV Deletion 23290073
dgv550e201 CNV Deletion 23290073
dgv3792n71 CNV Gain 21882294
esv2718298 CNV Deletion 23290073
nsv458376 CNV Gain 19166990
nsv911319 CNV Gain 21882294
esv2718300 CNV Deletion 23290073
esv2656893 CNV Deletion 23128226
esv2718301 CNV Deletion 23290073

Relevant External Links for ZNF93 Gene

HapMap Linkage Disequilibrium report
ZNF93

Disorders for ZNF93 Gene

Relevant External Links for ZNF93

Genetic Association Database (GAD)
ZNF93
Human Genome Epidemiology (HuGE) Navigator
ZNF93
genes like me logo Genes that share disorders with ZNF93: view

No data available for UniProtKB/Swiss-Prot for ZNF93 Gene

Publications for ZNF93 Gene

  1. The evolutionarily conserved Kruppel-associated box domain defines a subfamily of eukaryotic multifingered proteins. (PMID: 2023909) Bellefroid E.J. … Martial J.A. (Proc. Natl. Acad. Sci. U.S.A. 1991) 2 3 4
  2. Clustered organization of homologous KRAB zinc-finger genes with enhanced expression in human T lymphoid cells. (PMID: 8467795) Bellefroid E.J. … Martial J.A. (EMBO J. 1993) 2 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 3 4
  5. Genome-wide and candidate gene association study of cigarette smoking behaviors. (PMID: 19247474) Caporaso N. … Bergen A.W. (PLoS ONE 2009) 3 49

Products for ZNF93 Gene

Sources for ZNF93 Gene

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