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Aliases for ZNF93 Gene

Aliases for ZNF93 Gene

  • Zinc Finger Protein 93 2 3 5
  • Zinc Finger Protein 505 2 3 4
  • Zinc Finger Protein HTF34 3 4
  • ZNF505 3 4
  • Zinc Finger Protein 93 (HTF34) 2
  • HPF34 3
  • HTF34 3
  • TF34 3

External Ids for ZNF93 Gene

Previous HGNC Symbols for ZNF93 Gene

  • ZNF505

Previous GeneCards Identifiers for ZNF93 Gene

  • GC19U990113
  • GC19M020417
  • GC19P019871
  • GC19P019887
  • GC19P019805
  • GC19P019873
  • GC19P019979
  • GC19P020012

Summaries for ZNF93 Gene

GeneCards Summary for ZNF93 Gene

ZNF93 (Zinc Finger Protein 93) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZNF718.

UniProtKB/Swiss-Prot for ZNF93 Gene

  • Transcription factor specifically required to repress long interspersed nuclear element 1 (L1) retrotransposons: recognizes and binds L1 sequences and repress their expression by recruiting a repressive complex containing TRIM28/KAP1 (PubMed:25274305). Not able to repress expression of all subtypes of L1 elements. Binds to the 5 end of L1PA4, L1PA5 and L1PA6 subtypes, and some L1PA3 subtypes. Does not bind to L1PA7 or older subtypes nor at the most recently evolved L1PA2 and L1Hs. 50% of L1PA3 elements have lost the ZNF93-binding site, explaining why ZNF93 is not able to repress their expression (PubMed:25274305).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF93 Gene

Genomics for ZNF93 Gene

Regulatory Elements for ZNF93 Gene

Enhancers for ZNF93 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZNF93 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF93 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF93 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF93 Gene

Chromosome:
19
Start:
19,900,913 bp from pter
End:
19,935,998 bp from pter
Size:
35,086 bases
Orientation:
Plus strand

Genomic View for ZNF93 Gene

Genes around ZNF93 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF93 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF93 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF93 Gene

Proteins for ZNF93 Gene

  • Protein details for ZNF93 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P35789-ZNF93_HUMAN
    Recommended name:
    Zinc finger protein 93
    Protein Accession:
    P35789
    Secondary Accessions:
    • A6NMY2
    • B9EGT2
    • Q8N8Q4
    • Q9H9X5
    • Q9Y2N8

    Protein attributes for ZNF93 Gene

    Size:
    620 amino acids
    Molecular mass:
    70971 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Confers resistance to ET-743 (trabectedin, Yondelis) and PM00104 (Zalypsis), 2 marine derived compounds with antitumor activity in cancer cell lines.
    • ZNF93 is only present in primates and evolved to repress the primate L1 lineage until 12.5 million years. Evolution stopped when the L1PA3-subfamily of retrotransposons, that escape repression by ZNF93 through the removal of the ZNF93-binding site, appeared (PubMed:25274305).
    SequenceCaution:
    • Sequence=AAD22981.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=BAB14093.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF93 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF93 Gene

Proteomics data for ZNF93 Gene at MOPED

Post-translational modifications for ZNF93 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF93 Gene

Antibody Products

  • Abcam antibodies for ZNF93
  • Santa Cruz Biotechnology (SCBT) Antibodies for ZNF93

No data available for DME Specific Peptides for ZNF93 Gene

Domains & Families for ZNF93 Gene

Gene Families for ZNF93 Gene

Protein Domains for ZNF93 Gene

Suggested Antigen Peptide Sequences for ZNF93 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P35789

UniProtKB/Swiss-Prot:

ZNF93_HUMAN :
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 17 C2H2-type zinc fingers.
Domain:
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 17 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF93: view

Function for ZNF93 Gene

Molecular function for ZNF93 Gene

GENATLAS Biochemistry:
zinc finger protein 93 (HTF34),KRAB subfamily
UniProtKB/Swiss-Prot Function:
Transcription factor specifically required to repress long interspersed nuclear element 1 (L1) retrotransposons: recognizes and binds L1 sequences and repress their expression by recruiting a repressive complex containing TRIM28/KAP1 (PubMed:25274305). Not able to repress expression of all subtypes of L1 elements. Binds to the 5 end of L1PA4, L1PA5 and L1PA6 subtypes, and some L1PA3 subtypes. Does not bind to L1PA7 or older subtypes nor at the most recently evolved L1PA2 and L1Hs. 50% of L1PA3 elements have lost the ZNF93-binding site, explaining why ZNF93 is not able to repress their expression (PubMed:25274305).
genes like me logo Genes that share phenotypes with ZNF93: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF93 Gene

Localization for ZNF93 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF93 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF93 Gene COMPARTMENTS Subcellular localization image for ZNF93 gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for ZNF93 Gene

Pathways & Interactions for ZNF93 Gene

SuperPathways for ZNF93 Gene

No Data Available

Interacting Proteins for ZNF93 Gene

Gene Ontology (GO) - Biological Process for ZNF93 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045892 negative regulation of transcription, DNA-templated IDA 25274305
GO:0070895 negative regulation of transposon integration IDA 25274305
genes like me logo Genes that share ontologies with ZNF93: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF93 Gene

Drugs & Compounds for ZNF93 Gene

No Compound Related Data Available

Transcripts for ZNF93 Gene

Unigene Clusters for ZNF93 Gene

Zinc finger protein 93:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF93 Gene

No ASD Table

Relevant External Links for ZNF93 Gene

GeneLoc Exon Structure for
ZNF93
ECgene alternative splicing isoforms for
ZNF93

Expression for ZNF93 Gene

mRNA expression in normal human tissues for ZNF93 Gene

Protein differential expression in normal tissues from HIPED for ZNF93 Gene

This gene is overexpressed in Liver (42.0) and Lymph node (27.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF93 Gene



SOURCE GeneReport for Unigene cluster for ZNF93 Gene Hs.301059

genes like me logo Genes that share expression patterns with ZNF93: view

Protein tissue co-expression partners for ZNF93 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF93 Gene

Orthologs for ZNF93 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF93 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Zfp457 35
  • 65.73 (n)
  • 56.44 (a)
Zfp457 16
Zfp386 36
  • 37 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia ZNF93 35
  • 95.86 (n)
  • 95.48 (a)
cow
(Bos Taurus)
Mammalia -- 36
  • 57 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 40 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 40 (a)
ManyToMany
-- 36
  • 52 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 55 (a)
ManyToMany
-- 36
  • 37 (a)
ManyToMany
-- 36
  • 46 (a)
ManyToMany
-- 36
  • 42 (a)
ManyToMany
-- 36
  • 35 (a)
ManyToMany
-- 36
  • 35 (a)
ManyToMany
-- 36
  • 34 (a)
ManyToMany
-- 36
  • 31 (a)
ManyToMany
Species with no ortholog for ZNF93:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF93 Gene

ENSEMBL:
Gene Tree for ZNF93 (if available)
TreeFam:
Gene Tree for ZNF93 (if available)

Paralogs for ZNF93 Gene

(526) SIMAP similar genes for ZNF93 Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for ZNF93 Gene

genes like me logo Genes that share paralogs with ZNF93: view

Variants for ZNF93 Gene

Sequence variations from dbSNP and Humsavar for ZNF93 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs12151060 - 19,933,232(+) TAAAA(G/T)ATTCT reference, missense
rs7256224 -- 19,932,871(+) AATGC(A/T)GTGAG intron-variant
rs7257629 -- 19,929,862(+) gaacc(C/T)gggag intron-variant
rs7258260 -- 19,929,666(+) GGGCG(C/T)GGTGG intron-variant
rs7359838 -- 19,923,989(+) gaaat(C/T)atccg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF93 Gene

Variant ID Type Subtype PubMed ID
dgv3791n71 CNV Loss 21882294
nsv519535 CNV Gain 19592680
esv2718296 CNV Deletion 23290073
dgv550e201 CNV Deletion 23290073
dgv3792n71 CNV Gain 21882294
esv2718298 CNV Deletion 23290073
nsv458376 CNV Gain 19166990
nsv911319 CNV Gain 21882294
esv2718300 CNV Deletion 23290073
esv2656893 CNV Deletion 23128226
esv2718301 CNV Deletion 23290073

Variation tolerance for ZNF93 Gene

Residual Variation Intolerance Score: 89.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.86; 83.64% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ZNF93 Gene

Disorders for ZNF93 Gene

Relevant External Links for ZNF93

Genetic Association Database (GAD)
ZNF93
Human Genome Epidemiology (HuGE) Navigator
ZNF93
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF93

No disorders were found for ZNF93 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF93 Gene

Publications for ZNF93 Gene

  1. The evolutionarily conserved Kruppel-associated box domain defines a subfamily of eukaryotic multifingered proteins. (PMID: 2023909) Bellefroid E.J. … Martial J.A. (Proc. Natl. Acad. Sci. U.S.A. 1991) 2 3 4 67
  2. Clustered organization of homologous KRAB zinc-finger genes with enhanced expression in human T lymphoid cells. (PMID: 8467795) Bellefroid E.J. … Martial J.A. (EMBO J. 1993) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. An evolutionary arms race between KRAB zinc-finger genes ZNF91/93 and SVA/L1 retrotransposons. (PMID: 25274305) Jacobs F.M. … Haussler D. (Nature 2014) 3
  5. A whole genome screen for HIV restriction factors. (PMID: 22082156) Liu L. … McKnight A. (Retrovirology 2011) 3

Products for ZNF93 Gene

Sources for ZNF93 Gene

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