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Aliases for ZNF92 Gene

Aliases for ZNF92 Gene

  • Zinc Finger Protein 92 2 3
  • Zinc Finger Protein HTF12 3 4
  • Zinc Finger Protein 92 (HTF12) 2
  • Epididymis Luminal Protein 203 3
  • HEL-203 3
  • HPF12 3
  • HTF12 3
  • TF12 3

External Ids for ZNF92 Gene

Previous GeneCards Identifiers for ZNF92 Gene

  • GC19U990112
  • GC07P064236
  • GC07P064250
  • GC07P064282
  • GC07P064476
  • GC07P064838
  • GC07P061127

Summaries for ZNF92 Gene

GeneCards Summary for ZNF92 Gene

ZNF92 (Zinc Finger Protein 92) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding and transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZNF253.

UniProtKB/Swiss-Prot for ZNF92 Gene

  • May be involved in transcriptional regulation

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF92 Gene

Genomics for ZNF92 Gene

Regulatory Elements for ZNF92 Gene

Genomic Location for ZNF92 Gene

Chromosome:
7
Start:
65,373,799 bp from pter
End:
65,401,135 bp from pter
Size:
27,337 bases
Orientation:
Plus strand

Genomic View for ZNF92 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF92 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF92 Gene

Proteins for ZNF92 Gene

  • Protein details for ZNF92 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q03936-ZNF92_HUMAN
    Recommended name:
    Zinc finger protein 92
    Protein Accession:
    Q03936
    Secondary Accessions:
    • A6NNF9
    • Q8N492
    • Q8NB35

    Protein attributes for ZNF92 Gene

    Size:
    586 amino acids
    Molecular mass:
    68487 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF92 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF92 Gene

Proteomics data for ZNF92 Gene at MOPED

Post-translational modifications for ZNF92 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF92 Gene

No data available for DME Specific Peptides for ZNF92 Gene

Domains & Families for ZNF92 Gene

Gene Families for ZNF92 Gene

Protein Domains for ZNF92 Gene

Suggested Antigen Peptide Sequences for ZNF92 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q03936

UniProtKB/Swiss-Prot:

ZNF92_HUMAN :
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 16 C2H2-type zinc fingers.
Domain:
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 16 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF92: view

Function for ZNF92 Gene

Molecular function for ZNF92 Gene

GENATLAS Biochemistry:
zinc finger protein 92 (HTF12),KRAB subfamily
UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation

Gene Ontology (GO) - Molecular Function for ZNF92 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IBA --
GO:0003676 nucleic acid binding --
GO:0003700 transcription factor activity, sequence-specific DNA binding NAS 2023909
GO:0008270 zinc ion binding NAS 2023909
GO:0046872 metal ion binding --
genes like me logo Genes that share ontologies with ZNF92: view

Phenotypes for ZNF92 Gene

genes like me logo Genes that share phenotypes with ZNF92: view

Animal Model Products

CRISPR Products

miRNA for ZNF92 Gene

miRTarBase miRNAs that target ZNF92

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF92

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF92 Gene

Localization for ZNF92 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF92 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF92 Gene COMPARTMENTS Subcellular localization image for ZNF92 gene
Compartment Confidence
nucleus 3

Gene Ontology (GO) - Cellular Components for ZNF92 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IBA --
genes like me logo Genes that share ontologies with ZNF92: view

Pathways & Interactions for ZNF92 Gene

SuperPathways for ZNF92 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF92: view

Pathways by source for ZNF92 Gene

2 Reactome pathways for ZNF92 Gene

Gene Ontology (GO) - Biological Process for ZNF92 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA --
genes like me logo Genes that share ontologies with ZNF92: view

No data available for SIGNOR curated interactions for ZNF92 Gene

Drugs & Compounds for ZNF92 Gene

No Compound Related Data Available

Transcripts for ZNF92 Gene

Unigene Clusters for ZNF92 Gene

Zinc finger protein 92:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF92

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF92 Gene

ExUns: 1 ^ 2 ^ 3a · 3b
SP1:
SP2: -

Relevant External Links for ZNF92 Gene

GeneLoc Exon Structure for
ZNF92
ECgene alternative splicing isoforms for
ZNF92

Expression for ZNF92 Gene

mRNA expression in normal human tissues for ZNF92 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

SOURCE GeneReport for Unigene cluster for ZNF92 Gene Hs.9521

genes like me logo Genes that share expression patterns with ZNF92: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for ZNF92 Gene

Orthologs for ZNF92 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF92 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF92 35
  • 99.6 (n)
  • 99.83 (a)
ZNF92 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 56 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 40 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 41 (a)
ManyToMany
-- 36
  • 51 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Zfp493 36
  • 61 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 52 (a)
ManyToMany
-- 36
  • 35 (a)
ManyToMany
-- 36
  • 42 (a)
ManyToMany
-- 36
  • 40 (a)
ManyToMany
-- 36
  • 34 (a)
ManyToMany
-- 36
  • 33 (a)
ManyToMany
-- 36
  • 32 (a)
ManyToMany
-- 36
  • 29 (a)
ManyToMany
Species with no ortholog for ZNF92:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF92 Gene

ENSEMBL:
Gene Tree for ZNF92 (if available)
TreeFam:
Gene Tree for ZNF92 (if available)

Paralogs for ZNF92 Gene

(525) SIMAP similar genes for ZNF92 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for ZNF92 Gene

genes like me logo Genes that share paralogs with ZNF92: view

Variants for ZNF92 Gene

Sequence variations from dbSNP and Humsavar for ZNF92 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs1237946 -- 65,394,895(-) gccaa(C/G)gcggg intron-variant
rs3846970 -- 65,394,032(-) gacaa(C/T)gtccc intron-variant
rs3846971 -- 65,394,175(-) aggaa(A/C)aatat intron-variant
rs3846972 -- 65,399,999(-) AATTA(G/T)CTTAC utr-variant-3-prime
rs3857680 -- 65,390,398(-) aaaac(C/T)tgaag intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF92 Gene

Variant ID Type Subtype PubMed ID
dgv1147e201 CNV Deletion 23290073
dgv226e55 CNV Loss 17911159
nsv517778 CNV Gain+Loss 19592680
esv2734586 CNV Deletion 23290073
dgv227e55 CNV Loss 17911159
nsv888287 CNV Gain 21882294
dgv1213e199 CNV Deletion 23128226
dgv2088e1 CNV Complex 17122850
dgv228e55 CNV Gain 17911159
nsv7400 OTHER Inversion 18451855
esv33731 CNV Gain+Loss 17666407
nsv435849 CNV Deletion 17901297
dgv7310n71 CNV Gain 21882294
dgv7311n71 CNV Gain+Loss 21882294
dgv7312n71 CNV Loss 21882294
dgv7313n71 CNV Loss 21882294
nsv470266 CNV Gain 18288195
nsv470277 CNV Loss 18288195
dgv818n27 CNV Loss 19166990
dgv819n27 CNV Gain 19166990
dgv8n29 CNV Complex 16826518
nsv464530 CNV Loss 19166990
nsv831016 CNV Loss 17160897
dgv7316n71 CNV Loss 21882294
dgv229e55 CNV Loss 17911159
nsv888310 CNV Gain 21882294
nsv464534 CNV Loss 19166990
dgv7317n71 CNV Gain 21882294
nsv888316 CNV Gain+Loss 21882294
dgv7318n71 CNV Loss 21882294

Variation tolerance for ZNF92 Gene

Residual Variation Intolerance Score: 21.78% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.71; 83.04% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF92 Gene

HapMap Linkage Disequilibrium report
ZNF92

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF92 Gene

Disorders for ZNF92 Gene

Relevant External Links for ZNF92

Genetic Association Database (GAD)
ZNF92
Human Genome Epidemiology (HuGE) Navigator
ZNF92
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF92
genes like me logo Genes that share disorders with ZNF92: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF92 Gene

Publications for ZNF92 Gene

  1. Clustered organization of homologous KRAB zinc-finger genes with enhanced expression in human T lymphoid cells. (PMID: 8467795) Bellefroid E.J. … Martial J.A. (EMBO J. 1993) 2 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 67
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 67
  5. An atlas of combinatorial transcriptional regulation in mouse and man. (PMID: 20211142) Ravasi T. … Hayashizaki Y. (Cell 2010) 67

Products for ZNF92 Gene

Sources for ZNF92 Gene

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