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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZNF92 Gene

protein-coding   GIFtS: 53
GCID: GC07P064838

zinc finger protein 92

(Previous name: zinc finger protein 92 (HTF12) )
 Explore 1 disease affiliated with
ZNF92 via our new
 Human Malady Compendium 
Biological research products
for ZNF92
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Zinc Finger Protein 921 2
HPF121 2
TF121 2
Zinc Finger Protein HTF122 3
Zinc Finger Protein 92 (HTF12)1
HTF122

External Ids:    HGNC: 131681   Entrez Gene: 1683742   Ensembl: ENSG000001467577   OMIM: 6039745   UniProtKB: Q039363   

Export aliases for ZNF92 gene to outside databases

Previous GC identifers: GC19U990112 GC07P064236 GC07P064250 GC07P064282 GC07P064476 GC07P061127


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: ZNF92_HUMAN, Q03936
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.1  NT_007933.15  NT_079593.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZNF92 gene promoter:
         STAT5B   NF-YA   NF-YB   CBF-B   CBF-A   Ik-2   IRF-7A   CP1A   NF-Y   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ZNF92 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZNF92

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF92


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q11.21   Ensembl cytogenetic band:  7q11.21   HGNC cytogenetic band: 7q11.21

ZNF92 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF92 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P064838:  view genomic region     (about GC identifiers)

Start:
64,838,712 bp from pter      End:
64,866,038 bp from pter
Size:
27,327 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 64,176,361-64,203,591     

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ZNF92_HUMAN, Q03936 (See protein sequence)
Recommended Name: Zinc finger protein 92  
Size: 586 amino acids; 68487 Da
Subcellular location: Nucleus (Probable)
Developmental stage: Expressed early during embryonic development
Secondary accessions: A6NNF9 Q8N492 Q8NB35
Alternative splicing: 3 isoforms:  Q03936-1   Q03936-2   Q03936-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ZNF92: NX_Q03936

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q03936

  • ZNF92 Protein expression data from MOPED and PaxDb:    About this image 
    ZNF92 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_009070.2  NP_689839.1  

    ENSEMBL proteins: 
     ENSP00000332595   ENSP00000400495   ENSP00000396126   ENSP00000350113  
    Reactome Protein details: Q03936
    Human Recombinant Protein Products for ZNF92: 
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    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for ZNF92

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus NAS--
    GO:0005730NOT nucleolus IDA--

    ZNF92 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ZNF92 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR015880 Znf_C2H2-like
     IPR001909 Krueppel-associated_box
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q03936

    ProtoNet protein and cluster: Q03936

    1 Blocks protein family: IPB001909 KRAB box

    UniProtKB/Swiss-Prot: ZNF92_HUMAN, Q03936
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 16 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZNF92_HUMAN, Q03936
    Function: May be involved in transcriptional regulation

         Genatlas biochemistry entry for ZNF92:
    zinc finger protein 92 (HTF12),KRAB subfamily

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity NAS2023909
    GO:0008270zinc ion binding NAS2023909
         
    ZNF92 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ZNF92:
     Low eccentricity cells 

    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for ZNF92 

    miRNA
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF92


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Generic Transcription Pathway
    Generic Transcription Pathway1.00
    Gene Expression0.46

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    2        Reactome Pathways for ZNF92
        Generic Transcription Pathway
    Gene Expression



    ZNF92 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF92

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for ZNF92 (Q039363 ENSP000003325954) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CREB1P162203, ENSP000003876994I2D: score=1 STRING: ENSP00000387699
    STAT6P422263, ENSP000003001344I2D: score=1 STRING: ENSP00000300134
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent NAS--

    ZNF92 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZNF92
    Search CenterWatch for drugs/clinical trials and news about ZNF92 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZNF92 gene (2 alternative transcripts): 
    NM_007139.2  NM_152626.2  

    Unigene Cluster for ZNF92:

    Zinc finger protein 92
    Hs.9521  [show with all ESTs]
    Unigene Representative Sequence: NM_152626
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000328747(uc003ttz.3 uc003tua.3 uc010kzu.3) ENST00000488849
    ENST00000431504(uc003tub.3) ENST00000450302 ENST00000357512

    miRNA
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    Inhib. RNA
    Products:
         
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    Clone
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF92
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    Additional cDNA sequence: 

    AK091618.1 AK093566.1 BC036439.1 BC040594.1 BX647875.1 M61872.1 

    8 DOTS entries:

    DT.100812409  DT.99975752  DT.210131  DT.95157766  DT.121127724  DT.121127558  DT.91646854  DT.95209034 

    24/47 AceView cDNA sequences (see all 47):

    AX747097 NM_007139 AI469706 BX647875 BQ048958 CB162419 BC040594 AA329633 
    NM_152626 BP362173 BQ423752 AK091618 AI821000 BM724070 BQ938007 BE897039 
    AI925835 BG502050 AL598687 BC036439 CA437333 AK093566 AX748205 AA737692 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF92    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b
    SP1:                        
    SP2:        -               


    ECgene alternative splicing isoforms for ZNF92

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZNF92 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTCAGACTAA
    ZNF92 Expression
    About this image
    See ZNF92 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZNF92

    SOURCE GeneReport for Unigene cluster: Hs.9521
        SABiosciences Custom PCR Arrays for ZNF92

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF92

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for ZNF92 gene from 1/4 species (see all 4)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 7)
    --
    57(a)
    47(a)
    (see all 7)
    many ↔ many
    many ↔ many
    (see all 7)
    GL343330.1(1093706-1292239)
    AAWZ02037240(11818-13836)


    ENSEMBL Gene Tree for ZNF92 (if available)
    TreeFam Gene Tree for ZNF92 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZNF92 gene
    ZNF852  ZNF4932  ZNF4862  ZNF1002  ZNF7322  ZNF1382  ZNF6752  ZNF5062  
    ZNF2732  ZNF66P2  ZNF6952  ZNF6262  ZNF6802  ZNF2532  ZNF4792  ZNF932  
    ZNF4922  ZNF6822  ZNF6762  ZNF1412  ZNF6812  ZNF6792  ZNF2572  ZNF2542  
    ZNF7372  ZNF724P2  ZNF982  ZNF849P2  ZNF7162  ZNF7142  ZNF4292  ZNF4302  
    ZNF7302  ZNF6782  ZNF1172  ZNF7082  ZNF1072  ZNF4312  ZNF902  
    18/520 SIMAP similar genes for ZNF92 using alignment to 2 protein entries:     ZNF92_HUMAN (see all proteins) (see all similar genes):
    ZNF78L1    ZNF818P    ZNF708    ZNF726    ZFS-1    ZNF429
    ZNF431    ZNF737    ZNF138    ZNF85    ZNF208    ZNF257
    ZNF430    ZNF98    DKFZp686M04222    DKFZp762K012    ZNF479    ZNF716

    ZNF92 for paralogs           About GeneDecksing


    4 Pseudogenes.org Pseudogenes for ZNF92
    PGOHUM00000234246 PGOHUM00000234629 PGOHUM00000234643 PGOHUM00000233685


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/477 NCBI SNPs in ZNF92 are shown (see all 477    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2005683821,2
    --64836793(+) CTGAC-/TCATCT 2 -- us2k10--------
    rs557982221,2
    C--64836830(+) GGGTTG/AGGCGC 2 -- us2k13Minor allele frequency- A:0.31NA WA 124
    rs1858028041,2
    --64836846(+) CTCACA/GCCTGT 2 -- us2k10--------
    rs1894143891,2
    --64836850(+) CGCCTA/GTAATC 2 -- us2k10--------
    rs348494401,2
    C,F--64836863(-) CCCAA-/AGTGCT 2 -- us2k12Minor allele frequency- A:0.50NA CSA 4
    rs1923231241,2
    --64836867(+) CTTTGA/GGAGGC 2 -- us2k10--------
    rs1438120121,2
    --64836927(+) ACAAGC/GAGAAA 2 -- us2k10--------
    rs1466215311,2
    --64837047(+) GGTTGC/TGGTGA 2 -- us2k10--------
    rs1845341091,2
    --64837062(+) AGATCA/GTGCCA 2 -- us2k10--------
    rs358998511,2
    C--64837095(-) AGTTTC/TGCTCT 2 -- us2k14Minor allele frequency- T:0.12NA WA EA 360

    HapMap Linkage Disequilibrium report for ZNF92 (64838712 - 64866038 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 18 variations for ZNF92
         15/17 CNVs (see all 17): 52268 52269 7636 53749 52271 9058 9057 53866 34593 3682 8564 52270 34594 2698 9059
         1 Inversion: 37292

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ZNF92 for disorders           About GeneDecksing

    OMIM gene information: 603974    OMIM disorders: --

    1 disease for ZNF92:    About MalaCards
    myocardial stunning

    1 disease from the University of Copenhagen DISEASES database for ZNF92:
    Myocardial stunning
    Human Genome Epidemiology (HuGE) Navigator: ZNF92 (4 documents)

    Export disorders for ZNF92 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZNF92 gene, integrated from 9 sources (see all 13):
    (articles sorted by number of sources associating them with ZNF92)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. Clustered organization of homologous KRAB zinc-finger genes with enhanced expression in human T lymphoid cells. (PubMed id 8467795)1, 3 Bellefroid E.J.... Martial J.A. (1993)
    4. The evolutionarily conserved Kruppel-associated box domain defines a subfamily of eukaryotic multifingered proteins. (PubMed id 2023909)1, 2 Bellefroid E.J....Martial J.A. (1991)
    5. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    6. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    7. An atlas of combinatorial transcriptional regulation in mouse and man. (PubMed id 20211142)1 Ravasi T....Hayashizaki Y. (2010)
    8. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1 Bailey S.D....Anand S. (2010)
    9. Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)
    10. Genome-wide and candidate gene association study of cigarette smoking behaviors. (PubMed id 19247474)1 Caporaso N....Bergen A.W. (2009)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 168374 HGNC: 13168 AceView: ZNF92 Ensembl:ENSG00000146757 euGenes: HUgn168374
    ECgene: ZNF92 H-InvDB: ZNF92

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZNF92 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZNF92 gene:
    Search GeneIP for patents involving ZNF92

    GeneCards and IP:
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