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ZNF91 Gene

protein-coding   GIFtS: 51
GCID: GC19M023489

Zinc Finger Protein 91

(Previous names: zinc finger protein 91 (HPF7, HTF10))
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Aliases
for ZNF91 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Zinc Finger Protein 911 2
Zinc Finger Protein 91 (HPF7, HTF10)1 2
Zinc Finger Protein HPF72 3
Zinc Finger Protein HTF102 3
HPF72
HTF102

External Ids:    HGNC: 131661   Entrez Gene: 76442   Ensembl: ENSG000001672327   OMIM: 6039715   UniProtKB: Q054813   
ORGUL members:         

Export aliases for ZNF91 gene to outside databases

Previous GC identifers: GC19M024078 GC19M023871 GC19M023181 GC19M023333 GC19M023197 GC19M023540 GC19M023083


Summaries
for ZNF91 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ZNF91 Gene:
The ZNF91 gene encodes a zinc finger protein of the KRAB (Kruppel-associated box) subfamily (Bellefroid et al.,
1991, 1993 (PubMed 2023909) (PubMed 8467795)).(supplied by OMIM, May 2010)

GeneCards Summary for ZNF91 Gene:
ZNF91 (zinc finger protein 91) is a protein-coding gene. Diseases associated with ZNF91 include schizophrenia, and malaria. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ZNF521.




Genomic Views
for ZNF91 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NT_011295.12  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZNF91 gene promoter:
         C/EBPbeta   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ZNF91 promoter sequence
   Search Chromatin IP Primers for ZNF91

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF91


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p12   Ensembl cytogenetic band:  19p12   HGNC cytogenetic band: 19p12

ZNF91 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF91 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M023489:  view genomic region     (about GC identifiers)

Start:
 23,487,793 bp from pter      End:
 23,578,362 bp from pter
Size:
 90,570 bases      Orientation:
 minus strand

Proteins
for ZNF91 gene

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ZNF91_HUMAN, Q05481 (See protein sequence)
Recommended Name: Zinc finger protein 91  
Size: 1191 amino acids; 137217 Da
Sequence caution: Sequence=AAA58672.1; Type=Frameshift; Positions=184, 197;
Secondary accessions: A8K5E1 B7Z6G6
Alternative splicing: 2 isoforms:  Q05481-1   Q05481-2   

Explore the universe of human proteins at neXtProt for ZNF91: NX_Q05481

Explore proteomics data for ZNF91 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

    • See ZNF91 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003421.2  
    ENSEMBL proteins: 
     ENSP00000468867   ENSP00000300619   ENSP00000380272   ENSP00000471709  

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    Domains /
    Families
    for ZNF91 gene

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus    		 HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR001909 Krueppel-associated_box
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q05481

    ProtoNet protein and cluster: Q05481

    2 Blocks protein domains:
    IPB001909 KRAB box
    IPB007086 C2H2-type zinc finger signature


    UniProtKB/Swiss-Prot: ZNF91_HUMAN, Q05481
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 36 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    ZNF91 for domains           About GeneDecksing


    Function
    for ZNF91 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:
         Genatlas biochemistry entry for ZNF91:
    zinc finger protein 91 (HPF7,HTF10),KRAB subfamily,tightly linked to a full size LTR of human endogenous
    retrovirus HERV-K

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity NAS2023909
    GO:0008270zinc ion binding NAS8467795
    GO:0046872metal ion binding ----
         
    ZNF91 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ZNF91:
     Increased circadian period len 

    Animal Models:
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    Gene Editing
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    Localization
    for ZNF91 gene

    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZNF91_HUMAN, Q05481: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IDA--

    ZNF91 for ontologies           About GeneDecksing


    Pathways & Interactions
    for ZNF91 gene

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF91
    Interactions:

        Search GeneGlobe Interaction Network for ZNF91

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    5 Interacting proteins for ZNF91 (Q054813 ENSP000003006194) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NDEL1Q9GZM83, ENSP000003339824I2D: score=2 STRING: ENSP00000333982
    CHMP5Q9NZZ33, ENSP000002235004I2D: score=1 STRING: ENSP00000223500
    MAP4K3Q8IVH83I2D: score=2 
    MEF2CQ064133I2D: score=2 
    ELAVL1ENSP000003852694STRING: ENSP00000385269
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    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated ----

    ZNF91 for ontologies           About GeneDecksing



    Drugs & Compounds
    for ZNF91 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZNF91



    Transcripts
    for ZNF91 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ZNF91 gene: 
    NM_003430.2  

    Unigene Cluster for ZNF91:

    Zinc finger protein 91
    Hs.654471  [show with all ESTs]
    Unigene Representative Sequence: NM_003430
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000593645 ENST00000593292 ENST00000596528 ENST00000595893 ENST00000596989
    ENST00000597458 ENST00000599743 ENST00000599281 ENST00000593341 ENST00000300619(uc002nre.3 uc010xrj.2)
    ENST00000397082 ENST00000595533
    miRNA
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    Additional mRNA sequence: 

    AK291256.1 AK300294.1 L11672.1 M61871.1 

    8 DOTS entries:

    DT.210522  DT.100818305  DT.100818307  DT.101955200  DT.92422690  DT.102840677  DT.40190361  DT.95253698 

    Selected AceView cDNA sequences (see all 102):

    BX114356 AI377352 BQ777484 AW079579 AI801595 CA426699 BF446324 T17176 
    AU137884 AA493206 BQ788148 AA757237 CB154257 AI302001 BX471799 BQ012065 
    BX951206 AL706414 M61871 BP347428 AK090916 CD656997 BV188796 AI675444 

    GeneLoc Exon Structure


    Expression
    for ZNF91 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZNF91 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ZNF91 Expression
    About this image


    ZNF91 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Adipose (Muscoskeletal System)
             White adipocyte-like cells
    ZNF91 Protein expression data from MOPED1, PaxDb2 and MaxQB3:     About this image

    ZNF91 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.654471
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    In Situ
    Assay Products:     
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    Orthologs
    for ZNF91 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ZNF91 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia AA9871615
    Zfp8691    		 expressed sequence AA9871615
    zinc finger protein 8691    		 62.95(n)1
    54.35(a)1    		   13 (34.59 cM)5
    668691  NM_001039965.11  NP_001035054.11 
     675894435 
    lizard
    (Anolis carolinensis)    		 Reptilia --
    --
    (see all 57)    		 Uncharacterized protein
    (see all 57)    		 59(a)
    58(a)
    (see all 57)    		 many ↔ many
    many ↔ many
    (see all 57)    		 GL343434.1(236401-257660)
    GL343676.1(133636-262720)
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia LOC1017328561 zinc finger protein 91-like 52.65(n)
    49.54(a)    		   101732856  XM_004919570.1  XP_004919627.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii zgc:1714186
    zgc:1131006
    (see all 32)    		 zgc:113100
    (see all 32)    		 54(a)
    53(a)
    (see all 32)    		 many ↔ many
    many ↔ many
    (see all 32)    		 3(11648176-11681259) ENSDARG00000088051
    3(62866741-62992329) ENSDARG00000069796
    fruit fly
    (Drosophila melanogaster)    		 Insecta Aef13 negative regulation of transcription
    from Pol more    		 57(a)
    (best of 24)    		   78D2   --


    ENSEMBL Gene Tree for ZNF91 (if available)
    TreeFam Gene Tree for ZNF91 (if available)

    Paralogs
    for ZNF91 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZNF91 gene
    ZNF5212  PEG32  ZNF8502  ZNF7292  ZNF4232  ZNF2082  
    Selected SIMAP similar genes for ZNF91 using alignment to 3 protein entries:     ZNF91_HUMAN (see all proteins) (see all similar genes):
    MGC12518    ZNF468    ZNF701    ZNF724P    ZNF554    ZNF726
    ZNF254    ZNF273    ZNF721    ZNF726P1    ZNF675    ZNF98
    ZNF429    ZNF208    ZNF738    ZNF93    ZNF320    ZFS-1

    ZNF91 for paralogs           About GeneDecksing



    Genomic Variants
    for ZNF91 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZNF91 (see all 942)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 19 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs20095361,2
    		C,F--23540004(-) TCTCCC/TGGGCT 1 -- int17Minor allele frequency- T:0.16NA WA EA 366
    rs1478069571,2
    		C--23540039(+) AAACA-/AAC   
      AACAAC    AACAA     		1 -- cds10--------
    rs104151921,2
    		C,F--23540098(+) AACAAA/CAAATT 1 -- int12Minor allele frequency- C:0.08NA WA 120
    rs1425561241,2
    		C--23540145(+) AATTTC/GCATGG 1 -- int10--------
    rs1842261351,2
    		--23540151(+) CATGGA/GGAGAC 1 -- int10--------
    rs779672981,2
    		C,F--23540155(+) GGGAGA/GCTCTG 1 -- int11Minor allele frequency- G:0.03WA 118
    rs10200751,2
    		C,F,A,H--23540217(-) AAGCAA/GATTTA 1 -- int123Minor allele frequency- G:0.14NA EA NS WA 2560
    rs735650251,2
    		C,F--23540291(+) CAATAC/TTGCTT 1 -- int12Minor allele frequency- T:0.50WA 4
    rs299901,2
    		C,F,A--23540318(-) AAGTTT/CGAAAC 1 -- int111Minor allele frequency- C:0.32NA WA CSA EA 372
    rs1893661501,2
    		--23540364(+) ATCTTA/GGACTA 1 -- int10--------

    HapMap Linkage Disequilibrium report for ZNF91 (23487793 - 23578362 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for ZNF91:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv555e201CNV Deletion23290073
    nsv817826CNV Gain17921354
    dgv138e55CNV Gain17911159
    nsv833790CNV Gain17160897
    esv2751784CNV Gain17911159
    nsv9686CNV Gain+Loss18304495
    esv731CNV CNV17122850
    essv17031CNV CNV17122850
    dgv1068e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
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    Disorders / Diseases
    for ZNF91 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603971    OMIM disorders: --

    2 diseases for ZNF91:    
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    schizophrenia    malaria


    ZNF91 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ZNF91
    Human Genome Epidemiology (HuGE) Navigator: ZNF91 (1 document)

    Export disorders for ZNF91 gene to outside databases

    Publications
    for ZNF91 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZNF91 gene, integrated from 10 sources (see all 16):
    (articles sorted by number of sources associating them with ZNF91)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The evolutionarily conserved Kruppel-associated box domain defines a subfamily of eukaryotic multifingered proteins. (PubMed id 2023909)1, 2, 3 Bellefroid E.J....Martial J.A. (Proc. Natl. Acad. Sci. U.S.A. 1991)
    2. Clustered organization of homologous KRAB zinc-finger genes with enhanced expression in human T lymphoid cells. (PubMed id 8467795)1, 2, 9 Bellefroid E.J.... Martial J.A. (EMBO J. 1993)
    3. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PubMed id 19240061)1, 4 Trynka G....Wijmenga C. (Gut 2009)
    4. The human genome contains hundreds of genes coding for finger proteins of the Kruppel type. (PubMed id 2505992)1, 3 Bellefroid E.J....Martial J.A. (DNA 1989)
    5. Novel activity of KRAB domain that functions to reinforce nuclear localization of KRAB-containing zinc finger proteins by interacting with KAP1. (PubMed id 23665872)2 Wang W....Huang Z. (Cell. Mol. Life Sci. 2013)
    6. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    7. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    8. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    9. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (EMBO J. 2009)
    10. Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia. (PubMed id 17043677)1 Camargo L.M....Brandon N.J. (Mol. Psychiatry 2007)

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    Entrez Gene: 7644 HGNC: 13166 AceView: ZNF91 Ensembl:ENSG00000167232 euGenes: HUgn7644
    ECgene: ZNF91 H-InvDB: ZNF91

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    Specialized Databases showing ZNF91 gene

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    PharmGKB entry for ZNF91 Pharmacogenomics, SNPs, Pathways

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