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Aliases for ZNF91 Gene

Aliases for ZNF91 Gene

  • Zinc Finger Protein 91 2 3 5
  • Zinc Finger Protein 91 (HPF7, HTF10) 2 3
  • Zinc Finger Protein HTF10 3 4
  • Zinc Finger Protein HPF7 3 4
  • HTF10 3
  • HPF7 3

External Ids for ZNF91 Gene

Previous GeneCards Identifiers for ZNF91 Gene

  • GC19M024078
  • GC19M023871
  • GC19M023181
  • GC19M023197
  • GC19M023540
  • GC19M023083
  • GC19M023489

Summaries for ZNF91 Gene

Entrez Gene Summary for ZNF91 Gene

  • The ZNF91 gene encodes a zinc finger protein of the KRAB (Kruppel-associated box) subfamily (Bellefroid et al., 1991, 1993 [PubMed 2023909] [PubMed 8467795]).[supplied by OMIM, May 2010]

GeneCards Summary for ZNF91 Gene

ZNF91 (Zinc Finger Protein 91) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZNF208.

UniProtKB/Swiss-Prot for ZNF91 Gene

  • Transcription factor specifically required to repress SINE-VNTR-Alu (SVA) retrotransposons: recognizes and binds SVA sequences and represses their expression by recruiting a repressive complex containing TRIM28/KAP1 (PubMed:25274305). May also bind the promoter of the FCGR2B gene, leading to repress its expression; however, additional evidences are required to confirm this result in vivo (PubMed:11470777).

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF91 Gene

Genomics for ZNF91 Gene

Regulatory Elements for ZNF91 Gene

Enhancers for ZNF91 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G023685 1 ENCODE 10.2 -291.1 -291086 3.1 PKNOX1 ATF1 ZFP64 ARID4B SIN3A ZNF48 YY1 GTF3C2 CBX5 ZNF143 ZNF675 ENSG00000233836 ZNF91 GC19P023634
GH19G023798 0.6 ENCODE 3.9 -404.4 -404401 2.4 DPF2 GATA3 CTBP1 SMARCA4 ATF3 POLR2A CREB1 CUX1 HNF4A FOS ENSG00000233836 ZNF681 ENSG00000268362 ENSG00000269397 ZNF726 ZNF675 ZNF91 BNIP3P39 GC19P023828
GH19G023390 1.5 Ensembl ENCODE dbSUPER 0.7 +1.9 1893 5.9 PKNOX1 ATF1 ARID4B DMAP1 ZNF48 YY1 ETS1 ELK1 ZNF207 FOS LINC01224 ENSG00000267934 ENSG00000233836 ZNF91 CDC42EP3P1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF91 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF91 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000108374 660 1801 PKNOX1 ATF1 ARID4B DMAP1 ZNF48 YY1 ETS1 ELK1 ZNF207 FOS

Genomic Location for ZNF91 Gene

Chromosome:
19
Start:
23,304,991 bp from pter
End:
23,395,560 bp from pter
Size:
90,570 bases
Orientation:
Minus strand

Genomic View for ZNF91 Gene

Genes around ZNF91 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF91 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF91 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF91 Gene

Proteins for ZNF91 Gene

  • Protein details for ZNF91 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q05481-ZNF91_HUMAN
    Recommended name:
    Zinc finger protein 91
    Protein Accession:
    Q05481
    Secondary Accessions:
    • A8K5E1
    • B7Z6G6

    Protein attributes for ZNF91 Gene

    Size:
    1191 amino acids
    Molecular mass:
    137217 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • ZNF91 is only present in primates and emerged in the last common ancestor of humans and Old-World monkeys. It underwent structural changes between 8-12 Million years ago, probably to improve the proteins ability to bind and repress SINE-VNTR-Alu (SVA) retrotransposons elements (PubMed:25274305).
    SequenceCaution:
    • Sequence=AAA58672.1; Type=Frameshift; Positions=184, 197; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF91 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF91 Gene

Post-translational modifications for ZNF91 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF91 Gene

Domains & Families for ZNF91 Gene

Gene Families for ZNF91 Gene

Suggested Antigen Peptide Sequences for ZNF91 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q05481

UniProtKB/Swiss-Prot:

ZNF91_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF91: view

Function for ZNF91 Gene

Molecular function for ZNF91 Gene

GENATLAS Biochemistry:
zinc finger protein 91 (HPF7,HTF10),KRAB subfamily,tightly linked to a full size LTR of human endogenous retrovirus HERV-K
UniProtKB/Swiss-Prot Function:
Transcription factor specifically required to repress SINE-VNTR-Alu (SVA) retrotransposons: recognizes and binds SVA sequences and represses their expression by recruiting a repressive complex containing TRIM28/KAP1 (PubMed:25274305). May also bind the promoter of the FCGR2B gene, leading to repress its expression; however, additional evidences are required to confirm this result in vivo (PubMed:11470777).

Gene Ontology (GO) - Molecular Function for ZNF91 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding NAS 2023909
GO:0008270 zinc ion binding NAS 8467795
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF91: view
genes like me logo Genes that share phenotypes with ZNF91: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF91 Gene

Localization for ZNF91 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF91 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF91 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF91 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA,IDA 23665872
genes like me logo Genes that share ontologies with ZNF91: view

Pathways & Interactions for ZNF91 Gene

SuperPathways for ZNF91 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF91 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0045892 negative regulation of transcription, DNA-templated IDA 25274305
GO:0070895 negative regulation of transposon integration IDA 25274305
genes like me logo Genes that share ontologies with ZNF91: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF91 Gene

Drugs & Compounds for ZNF91 Gene

No Compound Related Data Available

Transcripts for ZNF91 Gene

Unigene Clusters for ZNF91 Gene

Zinc finger protein 91:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF91 Gene

No ASD Table

Relevant External Links for ZNF91 Gene

GeneLoc Exon Structure for
ZNF91
ECgene alternative splicing isoforms for
ZNF91

Expression for ZNF91 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF91 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZNF91 Gene

This gene is overexpressed in Plasma (52.2) and Prostate (12.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZNF91 Gene



Protein tissue co-expression partners for ZNF91 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF91 Gene:

ZNF91

SOURCE GeneReport for Unigene cluster for ZNF91 Gene:

Hs.654471

Evidence on tissue expression from TISSUES for ZNF91 Gene

  • Muscle(2.9)
  • Heart(2.7)
  • Nervous system(2.7)
  • Kidney(2.4)
  • Spleen(2.3)
  • Lung(2.2)
genes like me logo Genes that share expression patterns with ZNF91: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF91 Gene

Orthologs for ZNF91 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF91 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF91 34 35
  • 99.41 (n)
dog
(Canis familiaris)
Mammalia ZNF729 34
  • 63.98 (n)
-- 35
  • 17 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Zfp869 34 16
  • 62.95 (n)
rat
(Rattus norvegicus)
Mammalia Zfp869 34
  • 58.12 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 55 (a)
ManyToMany
-- 35
  • 55 (a)
ManyToMany
-- 35
  • 55 (a)
ManyToMany
-- 35
  • 53 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 46 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 59 (a)
ManyToMany
-- 35
  • 58 (a)
ManyToMany
-- 35
  • 58 (a)
ManyToMany
-- 35
  • 57 (a)
ManyToMany
-- 35
  • 56 (a)
ManyToMany
-- 35
  • 56 (a)
ManyToMany
-- 35
  • 56 (a)
ManyToMany
-- 35
  • 56 (a)
ManyToMany
-- 35
  • 55 (a)
ManyToMany
-- 35
  • 55 (a)
ManyToMany
-- 35
  • 55 (a)
ManyToMany
-- 35
  • 55 (a)
ManyToMany
-- 35
  • 55 (a)
ManyToMany
-- 35
  • 54 (a)
ManyToMany
-- 35
  • 54 (a)
ManyToMany
-- 35
  • 54 (a)
ManyToMany
-- 35
  • 54 (a)
ManyToMany
-- 35
  • 54 (a)
ManyToMany
-- 35
  • 54 (a)
ManyToMany
-- 35
  • 54 (a)
ManyToMany
-- 35
  • 54 (a)
ManyToMany
-- 35
  • 54 (a)
ManyToMany
-- 35
  • 54 (a)
ManyToMany
-- 35
  • 53 (a)
ManyToMany
-- 35
  • 53 (a)
ManyToMany
-- 35
  • 53 (a)
ManyToMany
-- 35
  • 53 (a)
ManyToMany
-- 35
  • 53 (a)
ManyToMany
-- 35
  • 53 (a)
ManyToMany
-- 35
  • 53 (a)
ManyToMany
-- 35
  • 53 (a)
ManyToMany
-- 35
  • 53 (a)
ManyToMany
-- 35
  • 53 (a)
ManyToMany
-- 35
  • 52 (a)
ManyToMany
-- 35
  • 52 (a)
ManyToMany
-- 35
  • 51 (a)
ManyToMany
-- 35
  • 51 (a)
ManyToMany
-- 35
  • 51 (a)
ManyToMany
-- 35
  • 51 (a)
ManyToMany
-- 35
  • 50 (a)
ManyToMany
-- 35
  • 50 (a)
ManyToMany
-- 35
  • 50 (a)
ManyToMany
-- 35
  • 49 (a)
ManyToMany
-- 35
  • 48 (a)
ManyToMany
-- 35
  • 48 (a)
ManyToMany
-- 35
  • 48 (a)
ManyToMany
-- 35
  • 47 (a)
ManyToMany
-- 35
  • 47 (a)
ManyToMany
-- 35
  • 47 (a)
ManyToMany
-- 35
  • 46 (a)
ManyToMany
-- 35
  • 46 (a)
ManyToMany
-- 35
  • 46 (a)
ManyToMany
-- 35
  • 46 (a)
ManyToMany
-- 35
  • 44 (a)
ManyToMany
-- 35
  • 43 (a)
ManyToMany
-- 35
  • 40 (a)
ManyToMany
-- 35
  • 38 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101732856 34
  • 52.65 (n)
zebrafish
(Danio rerio)
Actinopterygii zgc:171418 35
  • 54 (a)
ManyToMany
BX942815.1 35
  • 53 (a)
ManyToMany
zgc:113100 35
  • 53 (a)
ManyToMany
BX005085.3 35
  • 52 (a)
ManyToMany
BX321873.2 35
  • 52 (a)
ManyToMany
si:dkey-14o6.6 35
  • 52 (a)
ManyToMany
si:ch211-209p16.3 35
  • 51 (a)
ManyToMany
si:ch211-245n8.1 35
  • 51 (a)
ManyToMany
si:dkey-111k8.1 35
  • 51 (a)
ManyToMany
CR927215.1 35
  • 50 (a)
ManyToMany
si:ch211-208f21.5 35
  • 50 (a)
ManyToMany
si:dkey-92c21.3 35
  • 50 (a)
ManyToMany
BX510909.2 35
  • 48 (a)
ManyToMany
BX571760.1 35
  • 48 (a)
ManyToMany
CR847941.1 35
  • 48 (a)
ManyToMany
AL935044.2 35
  • 47 (a)
ManyToMany
BX510909.3 35
  • 47 (a)
ManyToMany
CR356223.5 35
  • 47 (a)
ManyToMany
si:dkey-196n19.7 35
  • 47 (a)
ManyToMany
CU929391.1 35
  • 46 (a)
ManyToMany
si:dkey-15h8.4 35
  • 46 (a)
ManyToMany
BX321887.1 35
  • 45 (a)
ManyToMany
CABZ01021450.1 35
  • 45 (a)
ManyToMany
CABZ01084613.2 35
  • 45 (a)
ManyToMany
CU467646.2 35
  • 45 (a)
ManyToMany
si:dkey-240n22.7 35
  • 45 (a)
ManyToMany
zgc:171570 35
  • 45 (a)
ManyToMany
zgc:174234 35
  • 45 (a)
ManyToMany
BX324216.1 35
  • 43 (a)
ManyToMany
zgc:113381 35
  • 42 (a)
ManyToMany
si:ch73-40a17.5 35
  • 40 (a)
ManyToMany
si:dkey-77f5.7 35
  • 20 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Aef1 36
  • 57 (a)
CG4936 36
  • 45 (a)
CG9793 36
  • 45 (a)
CG14655 36
  • 42 (a)
CG18262 36
  • 41 (a)
Meics 36
  • 40 (a)
l(2)35Ea 36
  • 38 (a)
CG10366 36
  • 36 (a)
CG10959 36
  • 36 (a)
CG6254 36
  • 36 (a)
grau 36
  • 34 (a)
CG4360 36
  • 32 (a)
CG7987 36
  • 32 (a)
su(Hw) 36
  • 32 (a)
CG3281 36
  • 31 (a)
CG4707 36
  • 31 (a)
D19A 36
  • 30 (a)
D19B 36
  • 30 (a)
CG10274 36
  • 29 (a)
fu2 36
  • 28 (a)
zf30C 36
  • 28 (a)
CG8484 36
  • 27 (a)
CG18476 36
  • 25 (a)
CG18011 36
  • 23 (a)
Oaz 35
  • 13 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011262 34
  • 45.74 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 48 (a)
ManyToMany
-- 35
  • 48 (a)
ManyToMany
-- 35
  • 47 (a)
ManyToMany
-- 35
  • 46 (a)
ManyToMany
-- 35
  • 45 (a)
ManyToMany
CSA.11281 35
  • 42 (a)
ManyToMany
-- 35
  • 41 (a)
ManyToMany
Species where no ortholog for ZNF91 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF91 Gene

ENSEMBL:
Gene Tree for ZNF91 (if available)
TreeFam:
Gene Tree for ZNF91 (if available)

Paralogs for ZNF91 Gene

(393) SIMAP similar genes for ZNF91 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ZNF91: view

Variants for ZNF91 Gene

Sequence variations from dbSNP and Humsavar for ZNF91 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000048132 -- 23,324,324(+) CTCCT(C/T)TTCTT intron-variant
rs1000068217 -- 23,362,982(+) CATTA(C/T)CCTGC intron-variant
rs1000103304 -- 23,337,585(+) AACAC(A/C)GAAAA intron-variant
rs1000118544 -- 23,341,280(+) TTCTG(A/C/G)CCTCA intron-variant
rs1000145293 -- 23,304,565(+) AATCC(C/T)AGCAC downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for ZNF91 Gene

Variant ID Type Subtype PubMed ID
dgv138e55 CNV gain 17911159
dgv1741n106 OTHER inversion 24896259
dgv514e201 CNV deletion 23290073
esv2751784 CNV gain 17911159
esv2758750 CNV gain+loss 17122850
esv3643991 CNV gain 21293372
esv3643993 CNV gain 21293372
nsv1057420 CNV gain 25217958
nsv1064929 CNV gain 25217958
nsv1078888 OTHER inversion 25765185
nsv1153393 OTHER inversion 26484159
nsv579034 CNV gain 21841781
nsv817826 CNV gain 17921354
nsv833790 CNV gain 17160897
nsv960817 CNV duplication 23825009
nsv9686 CNV gain+loss 18304495

Variation tolerance for ZNF91 Gene

Residual Variation Intolerance Score: 77.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.77; 89.47% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF91 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF91

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF91 Gene

Disorders for ZNF91 Gene

Relevant External Links for ZNF91

Genetic Association Database (GAD)
ZNF91
Human Genome Epidemiology (HuGE) Navigator
ZNF91
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF91

No disorders were found for ZNF91 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF91 Gene

Publications for ZNF91 Gene

  1. Clustered organization of homologous KRAB zinc-finger genes with enhanced expression in human T lymphoid cells. (PMID: 8467795) Bellefroid E.J. … Martial J.A. (EMBO J. 1993) 3 4 22 64
  2. The evolutionarily conserved Kruppel-associated box domain defines a subfamily of eukaryotic multifingered proteins. (PMID: 2023909) Bellefroid E.J. … Martial J.A. (Proc. Natl. Acad. Sci. U.S.A. 1991) 2 3 4 64
  3. An evolutionary arms race between KRAB zinc-finger genes ZNF91/93 and SVA/L1 retrotransposons. (PMID: 25274305) Jacobs F.M. … Haussler D. (Nature 2014) 3 4 64
  4. Novel activity of KRAB domain that functions to reinforce nuclear localization of KRAB-containing zinc finger proteins by interacting with KAP1. (PMID: 23665872) Wang W. … Huang Z. (Cell. Mol. Life Sci. 2013) 3 4 64
  5. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G. … Wijmenga C. (Gut 2009) 3 46 64

Products for ZNF91 Gene

Sources for ZNF91 Gene

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