ZNF91 Gene(Protein Coding)

Zinc Finger Protein 91

GCID:: GC19M023333

GIFtS:: 46

Genes Participants

Aliases for ZNF91 Gene

Zinc Finger Protein 91 ² ³ ⁵
Zinc Finger Protein 91 (HPF7, HTF10) ² ³
Zinc Finger Protein HTF10 ³ ⁴
Zinc Finger Protein HPF7 ³ ⁴
HTF10 ³
HPF7 ³

External Ids for ZNF91 Gene

HGNC: 13166
Entrez Gene: 7644
Ensembl: ENSG00000167232
OMIM: 603971
UniProtKB: Q05481

Previous GeneCards Identifiers for ZNF91 Gene

GC19M024078
GC19M023871
GC19M023181
GC19M023197
GC19M023540
GC19M023083
GC19M023489

Search aliases for ZNF91 gene in PubMed and other databases

Summaries for ZNF91 Gene

Entrez Gene Summary for ZNF91 Gene

The ZNF91 gene encodes a zinc finger protein of the KRAB (Kruppel-associated box) subfamily (Bellefroid et al., 1991, 1993 [PubMed 2023909] [PubMed 8467795]).[supplied by OMIM, May 2010]

GeneCards Summary for ZNF91 Gene

ZNF91 (Zinc Finger Protein 91) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZNF208.

UniProtKB/Swiss-Prot for ZNF91 Gene

ZNF91_HUMAN,Q05481

Transcription factor specifically required to repress SINE-VNTR-Alu (SVA) retrotransposons: recognizes and binds SVA sequences and represses their expression by recruiting a repressive complex containing TRIM28/KAP1 (PubMed:25274305). May also bind the promoter of the FCGR2B gene, leading to repress its expression; however, additional evidences are required to confirm this result in vivo (PubMed:11470777).

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF91 Gene

Genomics for ZNF91 Gene

Regulatory Elements for ZNF91 Gene

Enhancers for ZNF91 Gene

GeneHancer Identifier	Enhancer Score	Enhancer Sources	Gene-Enhancer Score	TSS distance (kb)	Number of Genes Away	Size (kb)	Transcription Factor Binding Sites within enhancer	Gene Targets for Enhancer
GH19G023685	1	ENCODE	10.2	-291.1	-291086	3.1	PKNOX1 ATF1 ZFP64 ARID4B SIN3A ZNF48 YY1 GTF3C2 CBX5 ZNF143	ZNF675 ENSG00000233836 ZNF91 GC19P023634
GH19G023798	0.6	ENCODE	3.9	-404.4	-404401	2.4	DPF2 GATA3 CTBP1 SMARCA4 ATF3 POLR2A CREB1 CUX1 HNF4A FOS	ENSG00000233836 ZNF681 ENSG00000268362 ENSG00000269397 ZNF726 ZNF675 ZNF91 BNIP3P39 GC19P023828
GH19G023390	1.5	Ensembl ENCODE dbSUPER	0.7	+1.9	1893	5.9	PKNOX1 ATF1 ARID4B DMAP1 ZNF48 YY1 ETS1 ELK1 ZNF207 FOS	LINC01224 ENSG00000267934 ENSG00000233836 ZNF91 CDC42EP3P1

- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF91 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF91 Gene

Ensembl Regulatory Elements (ENSRs)	TSS Distance (bp)	Size (bp)	Binding Sites for Transcription Factors within promoters
ENSR00000108374	660	1801	PKNOX1 ATF1 ARID4B DMAP1 ZNF48 YY1 ETS1 ELK1 ZNF207 FOS

Transcription factor binding sites by QIAGEN in the ZNF91 gene promoter:

See All at QIAGEN

Regulatory Element Products

Genomic Location for ZNF91 Gene

Chromosome:: 19

Start:: 23,304,991 bp from pter
End:: 23,395,560 bp from pter

Size:: 90,570 bases
Orientation:: Minus strand

Genomic View for ZNF91 Gene

Genes around ZNF91 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:

19p12 by Ensembl
19p12 by Entrez Gene
19p12 by HGNC

ZNF91 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)

Genomic Location for ZNF91 Gene — Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for ZNF91 Gene

Proteins for ZNF91 Gene

Protein details for ZNF91 Gene (UniProtKB/Swiss-Prot)
Protein Symbol:

Q05481-ZNF91_HUMAN

Recommended name:

Zinc finger protein 91

Protein Accession:

Q05481

Secondary Accessions:
- A8K5E1
- B7Z6G6
Protein attributes for ZNF91 Gene
Size:

1191 amino acids

Molecular mass:

137217 Da
Quaternary structure:

No Data Available

Miscellaneous:
ZNF91 is only present in primates and emerged in the last common ancestor of humans and Old-World monkeys. It underwent structural changes between 8-12 Million years ago, probably to improve the proteins ability to bind and repress SINE-VNTR-Alu (SVA) retrotransposons elements (PubMed:25274305).
SequenceCaution:
Sequence=AAA58672.1; Type=Frameshift; Positions=184, 197; Evidence={ECO:0000305};
Alternative splice isoforms for ZNF91 Gene
UniProtKB/Swiss-Prot:
Q05481-1

Q05481-2

neXtProt entry for ZNF91 Gene

Protein Expression for ZNF91 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for ZNF91 Gene

Modification sites at PhosphoSitePlus
- Q05481
Modification sites at neXtProt
- NX_Q05481

Other Protein References for ZNF91 Gene

ENSEMBL proteins:

REFSEQ proteins:

Antibody Products

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OriGene Antibodies for ZNF91
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Novus Biologicals Antibodies for ZNF91

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Invitrogen Antibodies for ZNF91

antibodies-online Antibodies for ZNF91: See all 29

Search GeneTex for Antibodies for ZNF91

Search Santa Cruz Biotechnology (SCBT) for ZNF91 Antibodies

Protein Products

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Origene Custom Protein Services for ZNF91

GenScript Custom Purified and Recombinant Proteins Services for ZNF91

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Search GeneTex for Proteins for ZNF91

Search for ZNF91 Proteins at ProSci

Assay Products

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GenScript Custom Assay Services for ZNF91

Browse Assay Kits at Cloud-Clone Corp.

Search antibodies-online for kits

No data available for DME Specific Peptides for ZNF91 Gene

Domains & Families for ZNF91 Gene

Gene Families for ZNF91 Gene

HGNC:

28 : Zinc fingers C2H2-type

Protein Domains for ZNF91 Gene

InterPro:

Blocks:

ProtoNet:

Q05481

Suggested Antigen Peptide Sequences for ZNF91 Gene

GenScript: Design optimal peptide antigens:

Zinc finger protein HTF10 (ZNF91_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q05481

UniProtKB/Swiss-Prot:

ZNF91_HUMAN :

Belongs to the krueppel C2H2-type zinc-finger protein family.

Family:

Belongs to the krueppel C2H2-type zinc-finger protein family.

Function for ZNF91 Gene

Molecular function for ZNF91 Gene

GENATLAS Biochemistry:

zinc finger protein 91 (HPF7,HTF10),KRAB subfamily,tightly linked to a full size LTR of human endogenous retrovirus HERV-K

ZNF91

UniProtKB/Swiss-Prot Function:

Transcription factor specifically required to repress SINE-VNTR-Alu (SVA) retrotransposons: recognizes and binds SVA sequences and represses their expression by recruiting a repressive complex containing TRIM28/KAP1 (PubMed:25274305). May also bind the promoter of the FCGR2B gene, leading to repress its expression; however, additional evidences are required to confirm this result in vivo (PubMed:11470777).

ZNF91_HUMAN,Q05481

Gene Ontology (GO) - Molecular Function for ZNF91 Gene

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	IEA	--
GO:0003700	transcription factor activity, sequence-specific DNA binding	NAS	2023909
GO:0008270	zinc ion binding	NAS	8467795
GO:0046872	metal ion binding	IEA	--

Phenotypes for ZNF91 Gene

GenomeRNAi human phenotypes for ZNF91:

Animal Model Products

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Cyagen custom Knockout/knockin (KOKI) mouse models for ZNF91
Cyagen custom CRISPR mouse and rat models for ZNF91
- CRISPR mouse model (ROSA26 knockin) rat model (ROSA26 knockin)
Cyagen custom transgenic mouse and rat models for ZNF91
- PiggyBac transgenic mouse and rat models

ViGene Biosciences lentiviral particle packaged cDNA for ZNF91 gene
- LH888604
ViGene Biosciences ready-to-package AAV shRNAs for ZNF91 gene
- SH888604
Search ViGene Biosciences for ZNF91

CRISPR Products

OriGene CRISPR knockouts for ZNF91
- KN223098

Santa Cruz Biotechnology (SCBT) CRISPR for ZNF91

GenScript: Design CRISPR guide RNA sequences for ZNF91

miRNA for ZNF91 Gene

miRTarBase miRNAs that target ZNF91

VectorBuilder custom plasmid, inducible vectors for ZNF91
VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ZNF91
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression

Cell Line Products

GenScript Custom overexpressing Cell Line Services for ZNF91

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Horizon Cell Lines for ZNF91

ViGene Biosciences adenoviral particle packaged cDNA for ZNF91 gene
- VH888604
ViGene Biosciences lentiviral particle packaged cDNA for ZNF91 gene
- LH888604
ViGene Biosciences ready-to-package AAV shRNAs for ZNF91 gene
- SH888604

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF91 Gene

Localization for ZNF91 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF91 Gene

Nucleus.

Q05481-ZNF91_HUMAN

Subcellular locations from

COMPARTMENTS

Compartment	Confidence
nucleus	5
cytosol	2

Gene Ontology (GO) - Cellular Components for ZNF91 Gene

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	IEA	--
GO:0005634	nucleus	IEA,IDA	23665872

Pathways & Interactions for ZNF91 Gene

SuperPathways for ZNF91 Gene

More details on SuperPathways for ZNF91

No Data Available

Interacting Proteins for ZNF91 Gene

http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000300619%0d%0a9606.ENSP00000369131%0d%0a9606.ENSP00000353622%0d%0a9606.ENSP00000367705%0d%0a9606.ENSP00000264705%0d%0a9606.ENSP00000265773%0d%0a — STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins: ENSP00000300619 Q05481-ZNF91_HUMAN for ZNF91 Gene via STRING IID

Symbol	External ID(s)	Details
BPTF	ENSP00000307208 ²⁰ Q12830 ¹⁴⁵	STRING: ENSP00000307208 IID: # pred=1
ELAVL1	ENSP00000385269 ²⁰ Q15717 ¹⁴⁵	STRING: ENSP00000385269 IID: # exp=1
HTT	ENSP00000347184 ²⁰ P42858 ¹⁴⁵	STRING: ENSP00000347184 IID: # exp=1
MEF2C	ENSP00000340874 ²⁰ Q06413 ¹⁴⁵	STRING: ENSP00000340874 IID: # exp=1
NDEL1	ENSP00000333982 ²⁰ Q9GZM8 ¹⁴⁵	STRING: ENSP00000333982 IID: # exp=1 # pred=1

Gene Ontology (GO) - Biological Process for ZNF91 Gene

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006351	transcription, DNA-templated	IEA	--
GO:0006355	regulation of transcription, DNA-templated	IEA	--
GO:0045892	negative regulation of transcription, DNA-templated	IDA	25274305
GO:0070895	negative regulation of transposon integration	IDA	25274305

No data available for Pathways by source and SIGNOR curated interactions for ZNF91 Gene

Drugs & Compounds for ZNF91 Gene

No Compound Related Data Available

Drug Products

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Transcripts for ZNF91 Gene

mRNA/cDNA for ZNF91 Gene

(7) REFSEQ mRNAs :

(4) Additional mRNA sequences :

(102) Selected AceView cDNA sequences:

(12) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF91 Gene

Zinc finger protein 91:

Hs.654471

Representative Sequences:

NM_003430

CRISPR Products

OriGene CRISPR knockouts for ZNF91
- KN223098

Santa Cruz Biotechnology (SCBT) CRISPR for ZNF91

GenScript: Design CRISPR guide RNA sequences for ZNF91

miRNA Products

Search ViGene Biosciences for ZNF91

SwitchGear ZNF91 3' UTR sequence
Browse SwitchGear 3'UTR luciferase reporter plasmids

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Inhibitory RNA Products

Origene shRNA, siRNA, and RNAi products in human, mouse, rat for ZNF91
Browse OriGene Inhibitory RNA Products For ZNF91

ViGene Biosciences ready-to-package AAV shRNAs for ZNF91 gene
- SH888604

Search Santa Cruz Biotechnology (SCBT) for ZNF91 siRNA/shRNA

Clone Products

OriGene clones in human for ZNF91
- SC337904
- SC315251
OriGene ORF clones in human for ZNF91
- RC240010
- RC223098
- RC223098L1
- RC223098L2
- RG223098
Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling

GenScript: Next-day shipping cDNA ORF clone for ZNF91 in any vector

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Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat

Search Addgene for plasmids for ZNF91

VectorBuilder custom plasmid, inducible vectors for ZNF91
VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ZNF91
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF91 Gene

No ASD Table

Relevant External Links for ZNF91 Gene

GeneLoc Exon Structure for: ZNF91
ECgene alternative splicing isoforms for: ZNF91

Expression for ZNF91 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF91 Gene

mRNA expression in normal human tissues for ZNF91 Gene

mRNA expression by BioGPS for ZNF91 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Brain (Nervous System)
- Pituitary Gland
Adipose (Muscoskeletal System)
- White adipocyte-like cells(Ahfeldt T et. al. 2012)

Protein differential expression in normal tissues from HIPED for ZNF91 Gene

This gene is overexpressed in Plasma (52.2) and Prostate (12.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZNF91 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZNF91 Gene

Integrated proteomics: cell line protein expression from ProteomicsDB, MOPED and MaxQB for ZNF91 Gene

Protein tissue co-expression partners for ZNF91 Gene

TMEM79

NURSA nuclear receptor signaling pathways regulating expression of ZNF91 Gene:

ZNF91

SOURCE GeneReport for Unigene cluster for ZNF91 Gene:

Hs.654471

Evidence on tissue expression from TISSUES for ZNF91 Gene

Muscle(2.9)
Heart(2.7)
Nervous system(2.7)
Kidney(2.4)
Spleen(2.3)
Lung(2.2)

Primer Products

OriGene qPCR primer pairs for ZNF91
- HP206950

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF91 Gene

Orthologs for ZNF91 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF91 Gene

Organism	Taxonomy	Gene	Similarity	Type	Details
chimpanzee (Pan troglodytes)	Mammalia	ZNF91 ³⁴ ³⁵	99.41 (n)		469069 XM_003316240.2 XP_003316288.2 19:23360819-23396643
dog (Canis familiaris)	Mammalia	ZNF729 ³⁴	63.98 (n)		100685304 XM_005616226.1 XP_005616283.1
dog (Canis familiaris)	Mammalia	-- ³⁵	17 (a)	ManyToMany	1:2976676-3061231
mouse (Mus musculus)	Mammalia	Zfp869 ³⁴ ¹⁶	62.95 (n)		66869 NM_001039965.1 NP_001035054.1 69706332
rat (Rattus norvegicus)	Mammalia	Zfp869 ³⁴	58.12 (n)		100361114 XM_006252990.1 XP_006253052.1
oppossum (Monodelphis domestica)	Mammalia	-- ³⁵	55 (a)	ManyToMany	4:413329120-413351225
		-- ³⁵	55 (a)	ManyToMany	4:413650376-413676069
		-- ³⁵	55 (a)	ManyToMany	Un:43545084-43610158
		-- ³⁵	53 (a)	ManyToMany	4:413485281-413510859
platypus (Ornithorhynchus anatinus)	Mammalia	-- ³⁵	46 (a)	OneToMany	Contig3143:5383-13391
lizard (Anolis carolinensis)	Reptilia	-- ³⁵	59 (a)	ManyToMany	GL343434.1:236401-257660
		-- ³⁵	58 (a)	ManyToMany	GL343434.1:88139-103400
		-- ³⁵	58 (a)	ManyToMany	GL343676.1:133636-262720
		-- ³⁵	57 (a)	ManyToMany	GL343786.1:58917-170574
		-- ³⁵	56 (a)	ManyToMany	GL343626.1:8361-37913
		-- ³⁵	56 (a)	ManyToMany	GL343676.1:69112-82322
		-- ³⁵	56 (a)	ManyToMany	GL343690.1:84834-124121
		-- ³⁵	56 (a)	ManyToMany	GL344142.1:17782-61632
		-- ³⁵	55 (a)	ManyToMany	2:199452678-199472294
		-- ³⁵	55 (a)	ManyToMany	GL343690.1:26887-41290
		-- ³⁵	55 (a)	ManyToMany	GL343733.1:29820-51787
		-- ³⁵	55 (a)	ManyToMany	GL343771.1:40749-72442
		-- ³⁵	55 (a)	ManyToMany	GL343931.1:39051-65856
		-- ³⁵	54 (a)	ManyToMany	2:197151657-197186845
		-- ³⁵	54 (a)	ManyToMany	GL343658.1:106897-136094
		-- ³⁵	54 (a)	ManyToMany	GL343667.1:176729-193915
		-- ³⁵	54 (a)	ManyToMany	GL343667.1:89504-111625
		-- ³⁵	54 (a)	ManyToMany	GL343673.1:117177-138884
		-- ³⁵	54 (a)	ManyToMany	GL343733.1:125230-159240
		-- ³⁵	54 (a)	ManyToMany	GL343773.1:15895-27886
		-- ³⁵	54 (a)	ManyToMany	GL343924.1:15071-52093
		-- ³⁵	54 (a)	ManyToMany	GL343934.1:100369-119417
		-- ³⁵	54 (a)	ManyToMany	GL343955.1:7130-58978
		-- ³⁵	53 (a)	ManyToMany	GL343434.1:478854-492060
		-- ³⁵	53 (a)	ManyToMany	GL343539.1:448629-458888
		-- ³⁵	53 (a)	ManyToMany	GL343571.1:343652-381239
		-- ³⁵	53 (a)	ManyToMany	GL343658.1:66416-82511
		-- ³⁵	53 (a)	ManyToMany	GL343777.1:150136-185200
		-- ³⁵	53 (a)	ManyToMany	GL343924.1:27608-81956
		-- ³⁵	53 (a)	ManyToMany	GL343934.1:30496-57198
		-- ³⁵	53 (a)	ManyToMany	GL344015.1:54868-85434
		-- ³⁵	53 (a)	ManyToMany	GL344187.1:48289-63468
		-- ³⁵	53 (a)	ManyToMany	GL344252.1:3384-46625
		-- ³⁵	52 (a)	ManyToMany	GL343775.1:143192-171801
		-- ³⁵	52 (a)	ManyToMany	GL344624.1:5323-21578
		-- ³⁵	51 (a)	ManyToMany	2:199024767-199103850
		-- ³⁵	51 (a)	ManyToMany	AAWZ02036143:3162-25035
		-- ³⁵	51 (a)	ManyToMany	GL343434.1:670616-700655
		-- ³⁵	51 (a)	ManyToMany	GL343538.1:37061-62541
		-- ³⁵	50 (a)	ManyToMany	2:197532732-197557744
		-- ³⁵	50 (a)	ManyToMany	GL343575.1:19040-66237
		-- ³⁵	50 (a)	ManyToMany	GL343944.1:72047-90252
		-- ³⁵	49 (a)	ManyToMany	2:194840020-194915535
		-- ³⁵	48 (a)	ManyToMany	2:196185385-196203432
		-- ³⁵	48 (a)	ManyToMany	AAWZ02036528:637-19026
		-- ³⁵	48 (a)	ManyToMany	GL343575.1:377918-402975
		-- ³⁵	47 (a)	ManyToMany	GL343312.1:335814-369088
		-- ³⁵	47 (a)	ManyToMany	GL343312.1:704501-722916
		-- ³⁵	47 (a)	ManyToMany	GL343771.1:12032-84600
		-- ³⁵	46 (a)	ManyToMany	GL343312.1:1154756-1203992
		-- ³⁵	46 (a)	ManyToMany	GL343312.1:60609-89985
		-- ³⁵	46 (a)	ManyToMany	GL343312.1:772275-786659
		-- ³⁵	46 (a)	ManyToMany	GL343532.1:82185-123726
		-- ³⁵	44 (a)	ManyToMany	GL343532.1:13578-48165
		-- ³⁵	43 (a)	ManyToMany	GL343312.1:1037109-1064987
		-- ³⁵	40 (a)	ManyToMany	2:195991217-196034905
		-- ³⁵	38 (a)	ManyToMany	GL343713.1:141888-153746
tropical clawed frog (Silurana tropicalis)	Amphibia	LOC101732856 ³⁴	52.65 (n)		101732856 XM_004919570.1 XP_004919627.1
zebrafish (Danio rerio)	Actinopterygii	zgc:171418 ³⁵	54 (a)	ManyToMany	3:11648176-11681259
		BX942815.1 ³⁵	53 (a)	ManyToMany	8:40886424-40976655
		zgc:113100 ³⁵	53 (a)	ManyToMany	3:62866741-62992329
		BX005085.3 ³⁵	52 (a)	ManyToMany	3:7708389-7743022
		BX321873.2 ³⁵	52 (a)	ManyToMany	5:54168993-54275750
		si:dkey-14o6.6 ³⁵	52 (a)	ManyToMany	4:48718445-48786306
		si:ch211-209p16.3 ³⁵	51 (a)	ManyToMany	4:50931905-50985314
		si:ch211-245n8.1 ³⁵	51 (a)	ManyToMany	4:54061582-54100085
		si:dkey-111k8.1 ³⁵	51 (a)	ManyToMany	3:61960034-61981874
		CR927215.1 ³⁵	50 (a)	ManyToMany	Zv9_scaffold3498:213095-338670
		si:ch211-208f21.5 ³⁵	50 (a)	ManyToMany	4:53493980-53618392
		si:dkey-92c21.3 ³⁵	50 (a)	ManyToMany	4:54655500-54685611
		BX510909.2 ³⁵	48 (a)	ManyToMany	Zv9_scaffold3560:72844-137635
		BX571760.1 ³⁵	48 (a)	ManyToMany	5:54412566-54549720
		CR847941.1 ³⁵	48 (a)	ManyToMany	5:72786648-72802266
		AL935044.2 ³⁵	47 (a)	ManyToMany	24:16413099-16429687
		BX510909.3 ³⁵	47 (a)	ManyToMany	Zv9_scaffold3560:34047-115165
		CR356223.5 ³⁵	47 (a)	ManyToMany	4:40483555-40572287
		si:dkey-196n19.7 ³⁵	47 (a)	ManyToMany	4:55819566-55945589
		CU929391.1 ³⁵	46 (a)	ManyToMany	15:43202165-43212667
		si:dkey-15h8.4 ³⁵	46 (a)	ManyToMany	22:2991972-3008911
		BX321887.1 ³⁵	45 (a)	ManyToMany	Zv9_scaffold3503:820885-896912
		CABZ01021450.1 ³⁵	45 (a)	ManyToMany	Zv9_scaffold3465:93174-160867
		CABZ01084613.2 ³⁵	45 (a)	ManyToMany	1:59489943-59514625
		CU467646.2 ³⁵	45 (a)	ManyToMany	4:61063651-61100204
		si:dkey-240n22.7 ³⁵	45 (a)	ManyToMany	4:60992875-61025675
		zgc:171570 ³⁵	45 (a)	ManyToMany	2:221432-246482
		zgc:174234 ³⁵	45 (a)	ManyToMany	3:8566034-8627581
		BX324216.1 ³⁵	43 (a)	ManyToMany	22:10129058-10151007
		zgc:113381 ³⁵	42 (a)	ManyToMany	4:58623056-58667327
		si:ch73-40a17.5 ³⁵	40 (a)	ManyToMany	2:319490-340465
		si:dkey-77f5.7 ³⁵	20 (a)	ManyToMany	15:982635-1009030
fruit fly (Drosophila melanogaster)	Insecta	Aef1 ³⁶	57 (a)
		CG4936 ³⁶	45 (a)
		CG9793 ³⁶	45 (a)
		CG14655 ³⁶	42 (a)
		CG18262 ³⁶	41 (a)
		Meics ³⁶	40 (a)
		l(2)35Ea ³⁶	38 (a)
		CG10366 ³⁶	36 (a)
		CG10959 ³⁶	36 (a)
		CG6254 ³⁶	36 (a)
		grau ³⁶	34 (a)
		CG4360 ³⁶	32 (a)
		CG7987 ³⁶	32 (a)
		su(Hw) ³⁶	32 (a)
		CG3281 ³⁶	31 (a)
		CG4707 ³⁶	31 (a)
		D19A ³⁶	30 (a)
		D19B ³⁶	30 (a)
		CG10274 ³⁶	29 (a)
		fu2 ³⁶	28 (a)
		zf30C ³⁶	28 (a)
		CG8484 ³⁶	27 (a)
		CG18476 ³⁶	25 (a)
		CG18011 ³⁶	23 (a)
		Oaz ³⁵	13 (a)	OneToMany	2R:10323404-10353386
African malaria mosquito (Anopheles gambiae)	Insecta	AgaP_AGAP011262 ³⁴	45.74 (n)		1270661 XM_309377.4 XP_309377.4
sea squirt (Ciona savignyi)	Ascidiacea	-- ³⁵	48 (a)	ManyToMany	reftig_249:324773-344406
		-- ³⁵	48 (a)	ManyToMany	reftig_99:375070-422370
		-- ³⁵	47 (a)	ManyToMany	reftig_131:447752-474163
		-- ³⁵	46 (a)	ManyToMany	reftig_97:391199-417749
		-- ³⁵	45 (a)	ManyToMany	reftig_238:345443-408380
		CSA.11281 ³⁵	42 (a)	ManyToMany	reftig_249:256792-298961
		-- ³⁵	41 (a)	ManyToMany	reftig_19:774445-791569

Species where no ortholog for ZNF91 was found in the sources mined by GeneCards:

A. gosspyii yeast (Ashbya gossypii)
Actinobacteria (Mycobacterium tuberculosis)
African clawed frog (Xenopus laevis)
Alicante grape (Vitis vinifera)
alpha proteobacteria (Wolbachia pipientis)
amoeba (Dictyostelium discoideum)
Archea (Pyrococcus horikoshii)
baker's yeast (Saccharomyces cerevisiae)
barley (Hordeum vulgare)
beta proteobacteria (Neisseria meningitidis)
bread mold (Neurospora crassa)
chicken (Gallus gallus)
Chromalveolata (Phytophthora infestans)
common water flea (Daphnia pulex)
corn (Zea mays)
cow (Bos Taurus)
E. coli (Escherichia coli)
filamentous fungi (Aspergillus nidulans)
Firmicute bacteria (Streptococcus pneumoniae)
fission yeast (Schizosaccharomyces pombe)
green algae (Chlamydomonas reinhardtii)
honey bee (Apis mellifera)
K. lactis yeast (Kluyveromyces lactis)
loblloly pine (Pinus taeda)
malaria parasite (Plasmodium falciparum)
medicago trunc (Medicago Truncatula)
moss (Physcomitrella patens)
orangutan (Pongo pygmaeus)
pig (Sus scrofa)
rainbow trout (Oncorhynchus mykiss)
rice (Oryza sativa)
rice blast fungus (Magnaporthe grisea)
schistosome parasite (Schistosoma mansoni)
sea anemone (Nematostella vectensis)
sea urchin (Strongylocentrotus purpuratus)
sorghum (Sorghum bicolor)
soybean (Glycine max)
stem rust fungus (Puccinia graminis)
sugarcane (Saccharum officinarum)
thale cress (Arabidopsis thaliana)
tomato (Lycopersicon esculentum)
toxoplasmosis (Toxoplasma gondii)
Trichoplax (Trichoplax adhaerens)
wheat (Triticum aestivum)
worm (Caenorhabditis elegans)

Evolution for ZNF91 Gene

ENSEMBL:: Gene Tree for ZNF91 (if available)
TreeFam:: Gene Tree for ZNF91 (if available)

Paralogs for ZNF91 Gene

ZNF208 ⁵
ZNF729 ⁵
ZNF107 ⁵
ZNF721 ⁵
ZNF99 ⁵
ZNF841 ⁵
ZNF845 ⁵
ZNF160 ⁵
ZNF850 ⁵
ZNF836 ⁵
ZNF808 ⁵
ZFP62 ⁵
ZNF347 ⁵
ZNF658 ⁵
ZNF665 ⁵
ZNF268 ⁵
ZNF624 ⁵
ZNF197 ⁵
ZNF585B ⁵
ZNF594 ⁵
ZNF585A ⁵
ZNF84 ⁵
ZNF420 ⁵
ZNF814 ⁵

(393) SIMAP similar genes for ZNF91 Gene using alignment to 3 proteins:

Variants for ZNF91 Gene

Sequence variations from dbSNP and Humsavar for ZNF91 Gene

SNP ID	Clin	Chr 19 pos	Sequence Context	Type
rs1000048132	--	23,324,324(+)	CTCCT(C/T)TTCTT	intron-variant
rs1000068217	--	23,362,982(+)	CATTA(C/T)CCTGC	intron-variant
rs1000103304	--	23,337,585(+)	AACAC(A/C)GAAAA	intron-variant
rs1000118544	--	23,341,280(+)	TTCTG(A/C/G)CCTCA	intron-variant
rs1000145293	--	23,304,565(+)	AATCC(C/T)AGCAC	downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for ZNF91 Gene

Variant ID	Type	Subtype	PubMed ID
dgv138e55	CNV	gain	17911159
dgv1741n106	OTHER	inversion	24896259
dgv514e201	CNV	deletion	23290073
esv2751784	CNV	gain	17911159
esv2758750	CNV	gain+loss	17122850
esv3643991	CNV	gain	21293372
esv3643993	CNV	gain	21293372
nsv1057420	CNV	gain	25217958
nsv1064929	CNV	gain	25217958
nsv1078888	OTHER	inversion	25765185
nsv1153393	OTHER	inversion	26484159
nsv579034	CNV	gain	21841781
nsv817826	CNV	gain	17921354
nsv833790	CNV	gain	17160897
nsv960817	CNV	duplication	23825009
nsv9686	CNV	gain+loss	18304495

Variation tolerance for ZNF91 Gene

Residual Variation Intolerance Score: 77.3% of all genes are more intolerant (likely to be disease-causing)

Gene Damage Index Score: 9.77; 89.47% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF91 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for: ZNF91

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF91 Gene

Disorders for ZNF91 Gene

Relevant External Links for ZNF91

Genetic Association Database (GAD): ZNF91
Human Genome Epidemiology (HuGE) Navigator: ZNF91
Atlas of Genetics and Cytogenetics in Oncology and Haematology:: ZNF91

No disorders were found for ZNF91 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF91 Gene

Publications for ZNF91 Gene

Clustered organization of homologous KRAB zinc-finger genes with enhanced expression in human T lymphoid cells. (PMID: 8467795) Bellefroid E.J. … Martial J.A. (EMBO J. 1993) ³ ⁴ ²² ⁶⁴
The evolutionarily conserved Kruppel-associated box domain defines a subfamily of eukaryotic multifingered proteins. (PMID: 2023909) Bellefroid E.J. … Martial J.A. (Proc. Natl. Acad. Sci. U.S.A. 1991) ² ³ ⁴ ⁶⁴
An evolutionary arms race between KRAB zinc-finger genes ZNF91/93 and SVA/L1 retrotransposons. (PMID: 25274305) Jacobs F.M. … Haussler D. (Nature 2014) ³ ⁴ ⁶⁴
Novel activity of KRAB domain that functions to reinforce nuclear localization of KRAB-containing zinc finger proteins by interacting with KAP1. (PMID: 23665872) Wang W. … Huang Z. (Cell. Mol. Life Sci. 2013) ³ ⁴ ⁶⁴
Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G. … Wijmenga C. (Gut 2009) ³ ⁴⁶ ⁶⁴

Search for latest publications for ZNF91 gene in PubMed and other databases

Products for ZNF91 Gene

OriGene Antibodies for ZNF91
- TA342423
- TA342424
Custom Antibody Services
Browse OriGene ELISA Kits
Custom Assay Services
Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for ZNF91
Origene Custom Protein Services for ZNF91
Origene shRNA, siRNA, and RNAi products in human, mouse, rat for ZNF91
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OriGene qPCR primer pairs for ZNF91
- HP206950
OriGene CRISPR knockouts for ZNF91
- KN223098
OriGene clones in human for ZNF91
- SC337904
- SC315251
OriGene ORF clones in human for ZNF91
- RC240010
- RC223098
- RC223098L1
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- RG223098
Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
Browse OriGene miRNA Products For ZNF91

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Novus Biologicals Antibodies for ZNF91
Novus Biologicals
Novus Biologicals Tissue Microarrays

Browse ProSpec Recombinant Proteins

Browse ESI BIO Cell Lines and PureStem Progenitors for ZNF91

SwitchGear ZNF91 3' UTR sequence
Browse SwitchGear 3'UTR luciferase reporter plasmids
SwitchGear ZNF91 promoter sequence
- S702694
Browse SwitchGear Promoter luciferase reporter plasmids

Invitrogen Antibodies for ZNF91

Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat

Browse compounds at ApexBio

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antibodies-online Antibodies for ZNF91: See all 29
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Search GeneTex for Proteins for ZNF91

ViGene Biosciences adenoviral particle packaged cDNA for ZNF91 gene
- VH888604
ViGene Biosciences lentiviral particle packaged cDNA for ZNF91 gene
- LH888604
ViGene Biosciences ready-to-package AAV shRNAs for ZNF91 gene
- SH888604
Search ViGene Biosciences for ZNF91

Search Santa Cruz Biotechnology (SCBT) for ZNF91 Antibodies
Search Santa Cruz Biotechnology (SCBT) for ZNF91 siRNA/shRNA
Santa Cruz Biotechnology (SCBT) CRISPR for ZNF91

Horizon Cell Lines for ZNF91

Cyagen custom Knockout/knockin (KOKI) mouse models for ZNF91
Cyagen custom CRISPR mouse and rat models for ZNF91
- CRISPR mouse model (ROSA26 knockin) rat model (ROSA26 knockin)
Cyagen custom transgenic mouse and rat models for ZNF91
- PiggyBac transgenic mouse and rat models

VectorBuilder custom plasmid, inducible vectors for ZNF91
VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ZNF91
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression

Sources for ZNF91 Gene

(1) GeneCards
(2) HGNC
(3) EntrezGene
(4) Swiss-Prot
(5) Ensembl
(6) OMIM
(7) GeneLoc
(8) Gene Wiki
(9) UCSC
(10) PhosphoSitePlus
(11) GO
(12) TrEMBL
(13) InterPro
(14) ProtoNet
(15) Blocks
(16) MGI
(17) IUBMB
(18) KEGG
(19) MINT
(20) STRING
(21) IntAct
(22) Novoseek
(23) PharmGKB
(24) DrugBank
(25) HMDB
(26) UniGene
(27) AceView
(28) RNAdb
(29) ASD
(30) ECgene
(31) GeneAnnot
(32) CGAP SAGE
(33) SOURCE
(34) HomoloGene
(35) PanEnsembl
(36) euGenes
(37) SGD
(38) FlyBase
(39) WormBase

(40) Pseudogene
(41) DGV
(42) dbSNP
(43) GenAtlas
(44) GeneTests
(45) HGMD
(46) GAD
(47) LSDB
(48) BGMUT
(49) HuGE
(50) eBioscience
(51) Atlas
(52) Cell Signaling Technology
(53) GenBank
(54) H-invDB
(55) HORDE
(56) HUGE
(57) IMGT
(58) Leiden
(59) MILLIPORE
(60) miRBase
(61) DME
(62) NCBI
(63) OriGene
(64) PubMed
(65) R&D Systems
(66) TGDB
(67) Tocris
(68) Abcam
(69) Novus
(70) ProSpec
(71) Sino Biological
(72) GenScript
(73) Qiagen
(74) Cloud-Clone Corp.
(75) Enzo Life Sciences
(76) OCA
(77) Proteopedia
(78) MOPED

(79) SPIRE
(80) neXtProt
(81) Reactome
(82) GeneGo (Thomson Reuters)
(83) fRNAdb
(84) DISEASES
(85) SIMAP
(86) GenomeRNAi
(87) LifeMap
(88) miRTarBase
(89) MalaCards
(90) Invitrogen
(91) BitterDB
(92) Vector BioLabs
(93) ESI-BIO
(94) RefSeq
(95) BioSystems
(96) MaxQB
(97) IUPHAR
(98) BioGPS
(99) Illumina
(100) COMPARTMENTS
(101) HOMER
(102) PaxDb
(103) ApexBio
(104) Addgene
(105) antibodies-online
(106) CYP
(107) NONCODE
(108) SwitchGear Genomics
(109) TreeFam
(110) PathCards
(111) GeneReviews
(112) GeneTex
(113) Taconic Biosciences
(114) GTEx
(115) ProteomicsDB
(116) SCBT
(117) DGIdb

(118) ClinicalTrials
(119) FDA Approved Drugs
(120) RVIS
(121) SIGNOR
(122) diseasecard
(123) NIH Rare Diseases
(124) Orphanet
(125) UMLS
(126) GTR
(127) Disease Ontology
(128) Genetics Home Reference
(129) MeSH
(130) MedlinePlus
(131) CDC
(132) NINDS
(133) NCBI Bookshelf
(134) ClinVar
(135) Gene Damage Index
(136) ViGene Biosciences
(137) HPO
(138) UDN
(139) VISTA
(140) FANTOM5
(141) ENCODE
(142) ProSci
(143) Horizon
(144) NURSA
(145) IID
(146) Cyagen
(147) VectorBuilder
(148) SNPedia
(149) BRCA Exchange
(150) St John's Lab
(151) CIViC
(152) ProteoGenix
(153) dbSUPER
(154) TISSUES
(155) Gene ORGANizer

ZNF91 Gene(Protein Coding)

Zinc Finger Protein 91

Aliases for ZNF91 Gene

Aliases for ZNF91 Gene

External Ids for ZNF91 Gene

Previous GeneCards Identifiers for ZNF91 Gene

Summaries for ZNF91 Gene

Entrez Gene Summary for ZNF91 Gene

GeneCards Summary for ZNF91 Gene

UniProtKB/Swiss-Prot for ZNF91 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF91 Gene

Genomics for ZNF91 Gene

Products:

Regulatory Elements for ZNF91 Gene

Regulatory Element Products

Genomic Location for ZNF91 Gene

Genomic View for ZNF91 Gene

RefSeq DNA sequence for ZNF91 Gene

Proteins for ZNF91 Gene

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Protein details for ZNF91 Gene (UniProtKB/Swiss-Prot)

Protein attributes for ZNF91 Gene

Alternative splice isoforms for ZNF91 Gene

neXtProt entry for ZNF91 Gene

Protein Expression for ZNF91 Gene

Post-translational modifications for ZNF91 Gene

Other Protein References for ZNF91 Gene

Antibody Products

Protein Products

Assay Products

No data available for DME Specific Peptides for ZNF91 Gene

Domains & Families for ZNF91 Gene

Gene Families for ZNF91 Gene

Protein Domains for ZNF91 Gene

Suggested Antigen Peptide Sequences for ZNF91 Gene

Graphical View of Domain Structure for InterPro Entry

UniProtKB/Swiss-Prot:

Function for ZNF91 Gene

Products:

Molecular function for ZNF91 Gene

Gene Ontology (GO) - Molecular Function for ZNF91 Gene

Phenotypes for ZNF91 Gene

Animal Model Products

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miRNA for ZNF91 Gene

miRNA Products

Inhibitory RNA Products

Clone Products

Cell Line Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF91 Gene

Localization for ZNF91 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF91 Gene

Subcellular locations from

Gene Ontology (GO) - Cellular Components for ZNF91 Gene

Pathways & Interactions for ZNF91 Gene

SuperPathways for ZNF91 Gene

Interacting Proteins for ZNF91 Gene

Gene Ontology (GO) - Biological Process for ZNF91 Gene

No data available for Pathways by source and SIGNOR curated interactions for ZNF91 Gene

Drugs & Compounds for ZNF91 Gene

Products:

Drug Products

Transcripts for ZNF91 Gene

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mRNA/cDNA for ZNF91 Gene

Unigene Clusters for ZNF91 Gene

CRISPR Products

miRNA Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF91 Gene

Relevant External Links for ZNF91 Gene

Expression for ZNF91 Gene

Products:

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF91 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZNF91 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZNF91 Gene

Protein tissue co-expression partners for ZNF91 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF91 Gene: