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Aliases for ZNF91 Gene

Aliases for ZNF91 Gene

  • Zinc Finger Protein 91 2 3
  • Zinc Finger Protein 91 (HPF7, HTF10) 2 3
  • Zinc Finger Protein HTF10 3 4
  • Zinc Finger Protein HPF7 3 4
  • HTF10 3
  • HPF7 3

External Ids for ZNF91 Gene

Summaries for ZNF91 Gene

Entrez Gene Summary for ZNF91 Gene

  • The ZNF91 gene encodes a zinc finger protein of the KRAB (Kruppel-associated box) subfamily (Bellefroid et al., 1991, 1993 [PubMed 2023909] [PubMed 8467795]).[supplied by OMIM, May 2010]

GeneCards Summary for ZNF91 Gene

ZNF91 (Zinc Finger Protein 91) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ZNF729.

UniProtKB/Swiss-Prot for ZNF91 Gene

  • Transcription factor specifically required to repress SINE-VNTR-Alu (SVA) retrotransposons: recognizes and binds SVA sequences and represses their expression by recruiting a repressive complex containing TRIM28/KAP1 (PubMed:25274305). May also bind the promoter of the FCGR2B gene, leading to repress its expression; however, additional evidences are required to confirm this result in vivo (PubMed:11470777).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF91 Gene

Genomics for ZNF91 Gene

Genomic Location for ZNF91 Gene

Start:
23,304,991 bp from pter
End:
23,395,560 bp from pter
Size:
90,570 bases
Orientation:
Minus strand

Genomic View for ZNF91 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF91 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF91 Gene

Regulatory Elements for ZNF91 Gene

Proteins for ZNF91 Gene

  • Protein details for ZNF91 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q05481-ZNF91_HUMAN
    Recommended name:
    Zinc finger protein 91
    Protein Accession:
    Q05481
    Secondary Accessions:
    • A8K5E1
    • B7Z6G6

    Protein attributes for ZNF91 Gene

    Size:
    1191 amino acids
    Molecular mass:
    137217 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • ZNF91 is only present in primates and emerged in the last common ancestor of humans and Old-World monkeys. It underwent structural changes between 8-12 Million years ago, probably to improve the proteins ability to bind and repress SINE-VNTR-Alu (SVA) retrotransposons elements (PubMed:25274305).
    SequenceCaution:
    • Sequence=AAA58672.1; Type=Frameshift; Positions=184, 197; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF91 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF91 Gene

Proteomics data for ZNF91 Gene at MOPED

Post-translational modifications for ZNF91 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF91 Gene

No data available for DME Specific Peptides for ZNF91 Gene

Domains for ZNF91 Gene

Gene Families for ZNF91 Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type

Suggested Antigen Peptide Sequences for ZNF91 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q05481

UniProtKB/Swiss-Prot:

ZNF91_HUMAN
Domain:
  • Contains 1 KRAB domain.:
    • Q05481
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.:
    • Q05481
Similarity:
  • Contains 36 C2H2-type zinc fingers.:
    • Q05481
genes like me logo Genes that share domains with ZNF91: view

Function for ZNF91 Gene

Molecular function for ZNF91 Gene

GENATLAS Biochemistry: zinc finger protein 91 (HPF7,HTF10),KRAB subfamily,tightly linked to a full size LTR of human endogenous retrovirus HERV-K
UniProtKB/Swiss-Prot Function: Transcription factor specifically required to repress SINE-VNTR-Alu (SVA) retrotransposons: recognizes and binds SVA sequences and represses their expression by recruiting a repressive complex containing TRIM28/KAP1 (PubMed:25274305). May also bind the promoter of the FCGR2B gene, leading to repress its expression; however, additional evidences are required to confirm this result in vivo (PubMed:11470777).

Gene Ontology (GO) - Molecular Function for ZNF91 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0003700 sequence-specific DNA binding transcription factor activity NAS 2023909
GO:0008270 zinc ion binding NAS 8467795
GO:0046872 metal ion binding --
genes like me logo Genes that share ontologies with ZNF91: view

Phenotypes for ZNF91 Gene

GenomeRNAi human phenotypes for ZNF91:
genes like me logo Genes that share phenotypes with ZNF91: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ZNF91 Gene

Localization for ZNF91 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF91 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF91 Gene COMPARTMENTS Subcellular localization image for ZNF91 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF91 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IDA 23665872
genes like me logo Genes that share ontologies with ZNF91: view

Pathways for ZNF91 Gene

SuperPathways for ZNF91 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF91 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated --
GO:0045892 negative regulation of transcription, DNA-templated IDA 25274305
GO:0070895 negative regulation of transposon integration IDA 25274305
genes like me logo Genes that share ontologies with ZNF91: view

No data available for Pathways by source for ZNF91 Gene

Transcripts for ZNF91 Gene

Unigene Clusters for ZNF91 Gene

Zinc finger protein 91:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF91 Gene

No ASD Table

Relevant External Links for ZNF91 Gene

GeneLoc Exon Structure for
ZNF91
ECgene alternative splicing isoforms for
ZNF91

Expression for ZNF91 Gene

mRNA expression in normal human tissues for ZNF91 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZNF91 Gene

SOURCE GeneReport for Unigene cluster for ZNF91 Gene Hs.654471

genes like me logo Genes that share expressions with ZNF91: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF91 Gene

Orthologs for ZNF91 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF91 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF91 35
  • 99.41 (n)
  • 98.82 (a)
ZNF91 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 36
  • 17 (a)
ManyToMany
ZNF729 35
  • 63.98 (n)
  • 53.17 (a)
mouse
(Mus musculus)
Mammalia AA987161 16
Zfp869 35
  • 62.95 (n)
  • 54.35 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 55 (a)
ManyToMany
-- 36
  • 53 (a)
ManyToMany
-- 36
  • 55 (a)
ManyToMany
-- 36
  • 55 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 46 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Zfp869 35
  • 58.12 (n)
  • 48.83 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 49 (a)
ManyToMany
-- 36
  • 40 (a)
ManyToMany
-- 36
  • 48 (a)
ManyToMany
-- 36
  • 54 (a)
ManyToMany
-- 36
  • 50 (a)
ManyToMany
-- 36
  • 51 (a)
ManyToMany
-- 36
  • 55 (a)
ManyToMany
-- 36
  • 51 (a)
ManyToMany
-- 36
  • 48 (a)
ManyToMany
-- 36
  • 43 (a)
ManyToMany
-- 36
  • 46 (a)
ManyToMany
-- 36
  • 47 (a)
ManyToMany
-- 36
  • 46 (a)
ManyToMany
-- 36
  • 47 (a)
ManyToMany
-- 36
  • 46 (a)
ManyToMany
-- 36
  • 59 (a)
ManyToMany
-- 36
  • 53 (a)
ManyToMany
-- 36
  • 51 (a)
ManyToMany
-- 36
  • 58 (a)
ManyToMany
-- 36
  • 44 (a)
ManyToMany
-- 36
  • 46 (a)
ManyToMany
-- 36
  • 51 (a)
ManyToMany
-- 36
  • 53 (a)
ManyToMany
-- 36
  • 53 (a)
ManyToMany
-- 36
  • 50 (a)
ManyToMany
-- 36
  • 48 (a)
ManyToMany
-- 36
  • 56 (a)
ManyToMany
-- 36
  • 54 (a)
ManyToMany
-- 36
  • 53 (a)
ManyToMany
-- 36
  • 54 (a)
ManyToMany
-- 36
  • 54 (a)
ManyToMany
-- 36
  • 54 (a)
ManyToMany
-- 36
  • 58 (a)
ManyToMany
-- 36
  • 56 (a)
ManyToMany
-- 36
  • 55 (a)
ManyToMany
-- 36
  • 56 (a)
ManyToMany
-- 36
  • 38 (a)
ManyToMany
-- 36
  • 54 (a)
ManyToMany
-- 36
  • 55 (a)
ManyToMany
-- 36
  • 47 (a)
ManyToMany
-- 36
  • 55 (a)
ManyToMany
-- 36
  • 54 (a)
ManyToMany
-- 36
  • 52 (a)
ManyToMany
-- 36
  • 53 (a)
ManyToMany
-- 36
  • 57 (a)
ManyToMany
-- 36
  • 54 (a)
ManyToMany
-- 36
  • 53 (a)
ManyToMany
-- 36
  • 55 (a)
ManyToMany
-- 36
  • 54 (a)
ManyToMany
-- 36
  • 53 (a)
ManyToMany
-- 36
  • 50 (a)
ManyToMany
-- 36
  • 54 (a)
ManyToMany
-- 36
  • 53 (a)
ManyToMany
-- 36
  • 56 (a)
ManyToMany
-- 36
  • 53 (a)
ManyToMany
-- 36
  • 53 (a)
ManyToMany
-- 36
  • 52 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101732856 35
  • 52.65 (n)
  • 49.54 (a)
zebrafish
(Danio rerio)
Actinopterygii AL935044.2 36
  • 47 (a)
ManyToMany
BX005085.3 36
  • 52 (a)
ManyToMany
BX321873.2 36
  • 52 (a)
ManyToMany
BX321887.1 36
  • 45 (a)
ManyToMany
BX324216.1 36
  • 43 (a)
ManyToMany
BX510909.2 36
  • 48 (a)
ManyToMany
BX510909.3 36
  • 47 (a)
ManyToMany
BX571760.1 36
  • 48 (a)
ManyToMany
BX942815.1 36
  • 53 (a)
ManyToMany
CABZ01021450.1 36
  • 45 (a)
ManyToMany
CABZ01084613.2 36
  • 45 (a)
ManyToMany
CR356223.5 36
  • 47 (a)
ManyToMany
CR847941.1 36
  • 48 (a)
ManyToMany
CR927215.1 36
  • 50 (a)
ManyToMany
CU467646.2 36
  • 45 (a)
ManyToMany
CU929391.1 36
  • 46 (a)
ManyToMany
si:ch211-208f21.5 36
  • 50 (a)
ManyToMany
si:ch211-209p16.3 36
  • 51 (a)
ManyToMany
si:ch211-245n8.1 36
  • 51 (a)
ManyToMany
si:ch73-40a17.5 36
  • 40 (a)
ManyToMany
si:dkey-111k8.1 36
  • 51 (a)
ManyToMany
si:dkey-14o6.6 36
  • 52 (a)
ManyToMany
si:dkey-15h8.4 36
  • 46 (a)
ManyToMany
si:dkey-196n19.7 36
  • 47 (a)
ManyToMany
si:dkey-240n22.7 36
  • 45 (a)
ManyToMany
si:dkey-77f5.7 36
  • 20 (a)
ManyToMany
si:dkey-92c21.3 36
  • 50 (a)
ManyToMany
zgc:113100 36
  • 53 (a)
ManyToMany
zgc:113381 36
  • 42 (a)
ManyToMany
zgc:171418 36
  • 54 (a)
ManyToMany
zgc:171570 36
  • 45 (a)
ManyToMany
zgc:174234 36
  • 45 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011262 35
  • 45.74 (n)
  • 37.82 (a)
fruit fly
(Drosophila melanogaster)
Insecta Oaz 36
  • 13 (a)
OneToMany
CG8484 37
  • 27 (a)
su(Hw) 37
  • 32 (a)
CG10366 37
  • 36 (a)
CG4707 37
  • 31 (a)
Meics 37
  • 40 (a)
CG9793 37
  • 45 (a)
CG10959 37
  • 36 (a)
zf30C 37
  • 28 (a)
l(2)35Ea 37
  • 38 (a)
CG18011 37
  • 23 (a)
CG18262 37
  • 41 (a)
CG10274 37
  • 29 (a)
D19A 37
  • 30 (a)
CG4360 37
  • 32 (a)
CG6254 37
  • 36 (a)
grau 37
  • 34 (a)
CG7987 37
  • 32 (a)
CG18476 37
  • 25 (a)
CG14655 37
  • 42 (a)
D19B 37
  • 30 (a)
CG4936 37
  • 45 (a)
CG3281 37
  • 31 (a)
fu2 37
  • 28 (a)
Aef1 37
  • 57 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 47 (a)
ManyToMany
-- 36
  • 41 (a)
ManyToMany
-- 36
  • 45 (a)
ManyToMany
-- 36
  • 48 (a)
ManyToMany
-- 36
  • 46 (a)
ManyToMany
-- 36
  • 48 (a)
ManyToMany
CSA.11281 36
  • 42 (a)
ManyToMany
Species with no ortholog for ZNF91:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF91 Gene

ENSEMBL:
Gene Tree for ZNF91 (if available)
TreeFam:
Gene Tree for ZNF91 (if available)

Paralogs for ZNF91 Gene

Paralogs for ZNF91 Gene

Selected SIMAP similar genes for ZNF91 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ZNF91: view

Variants for ZNF91 Gene

Sequence variations from dbSNP and Humsavar for ZNF91 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs29987 -- 23,340,196(+) gaaca(C/G)aacca intron-variant
rs29988 -- 23,340,814(+) aatca(A/G)caggg intron-variant
rs29989 -- 23,354,235(+) aaaga(A/T)tatcc intron-variant
rs29990 -- 23,357,516(-) AAGTT(C/T)GAAAC intron-variant, downstream-variant-500B
rs29991 -- 23,357,870(+) GCGAT(C/T)GTTAT utr-variant-3-prime, intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF91 Gene

Variant ID Type Subtype PubMed ID
esv731 CNV CNV 17122850
esv2751784 CNV Gain 17911159
dgv138e55 CNV Gain 17911159
essv17031 CNV CNV 17122850
dgv1068e1 CNV Complex 17122850
nsv9686 CNV Gain+Loss 18304495
nsv817826 CNV Gain 17921354
nsv833790 CNV Gain 17160897
dgv555e201 CNV Deletion 23290073

Relevant External Links for ZNF91 Gene

HapMap Linkage Disequilibrium report
ZNF91

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF91 Gene

Disorders for ZNF91 Gene

Relevant External Links for ZNF91

Genetic Association Database (GAD)
ZNF91
Human Genome Epidemiology (HuGE) Navigator
ZNF91
genes like me logo Genes that share disorders with ZNF91: view

No data available for UniProtKB/Swiss-Prot for ZNF91 Gene

Publications for ZNF91 Gene

  1. Clustered organization of homologous KRAB zinc-finger genes with enhanced expression in human T lymphoid cells. (PMID: 8467795) Bellefroid E.J. … Martial J.A. (EMBO J. 1993) 3 4 23
  2. The evolutionarily conserved Kruppel-associated box domain defines a subfamily of eukaryotic multifingered proteins. (PMID: 2023909) Bellefroid E.J. … Martial J.A. (Proc. Natl. Acad. Sci. U.S.A. 1991) 2 3 4
  3. The human genome contains hundreds of genes coding for finger proteins of the Kruppel type. (PMID: 2505992) Bellefroid E.J. … Martial J.A. (DNA 1989) 2 3
  4. Characterization of the human Fc gamma RIIB gene promoter: human zinc-finger proteins (ZNF140 and ZNF91) that bind to different regions function as transcription repressors. (PMID: 11470777) Nishimura T. … Taniyama T. (Int. Immunol. 2001) 3 4
  5. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G. … Wijmenga C. (Gut 2009) 3 48

Products for ZNF91 Gene

Sources for ZNF91 Gene

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