ZNF91 Gene(Protein Coding)

Zinc Finger Protein 91

GCID:: GC19M023333

GIFtS:: 47

Genes Participants

Aliases for ZNF91 Gene

Zinc Finger Protein 91 ² ³ ⁵
Zinc Finger Protein 91 (HPF7, HTF10) ² ³
Zinc Finger Protein HTF10 ³ ⁴
Zinc Finger Protein HPF7 ³ ⁴
HTF10 ³
HPF7 ³

External Ids for ZNF91 Gene

HGNC: 13166
Entrez Gene: 7644
Ensembl: ENSG00000167232
OMIM: 603971
UniProtKB: Q05481

Previous GeneCards Identifiers for ZNF91 Gene

GC19M024078
GC19M023871
GC19M023181
GC19M023197
GC19M023540
GC19M023083
GC19M023489

Export aliases for ZNF91 gene to outside databases

Summaries for ZNF91 Gene

Entrez Gene Summary for ZNF91 Gene

The ZNF91 gene encodes a zinc finger protein of the KRAB (Kruppel-associated box) subfamily (Bellefroid et al., 1991, 1993 [PubMed 2023909] [PubMed 8467795]).[supplied by OMIM, May 2010]

GeneCards Summary for ZNF91 Gene

ZNF91 (Zinc Finger Protein 91) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZNF729.

UniProtKB/Swiss-Prot for ZNF91 Gene

ZNF91_HUMAN,Q05481

Transcription factor specifically required to repress SINE-VNTR-Alu (SVA) retrotransposons: recognizes and binds SVA sequences and represses their expression by recruiting a repressive complex containing TRIM28/KAP1 (PubMed:25274305). May also bind the promoter of the FCGR2B gene, leading to repress its expression; however, additional evidences are required to confirm this result in vivo (PubMed:11470777).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF91 Gene

Genomics for ZNF91 Gene

Regulatory Elements for ZNF91 Gene

Enhancers for ZNF91 Gene

GeneHancer Identifier	Score	Enhancer Sources	TSS distance (kb)	Number of Genes Away	Size (kb)	Transcription Factor Binding Sites within enhancer	Other Gene Targets for Enhancer

Enhancers around ZNF91 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF91 Gene

Ensembl Regulatory Elements (ENSRs)	TSS Distance (bp)	Size (bp)	Binding Sites for Transcription Factors within promoters

ENSRs around ZNF91 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the ZNF91 gene promoter:

See All at QIAGEN

Regulatory Element Products

Genomic Location for ZNF91 Gene

Chromosome:: 19

Start:: 23,304,991 bp from pter
End:: 23,395,560 bp from pter

Size:: 90,570 bases
Orientation:: Minus strand

Genomic View for ZNF91 Gene

Genes around ZNF91 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:

19p12 by Ensembl
19p12 by Entrez Gene
19p12 by HGNC

ZNF91 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)

Genomic Location for ZNF91 Gene — Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for ZNF91 Gene

Proteins for ZNF91 Gene

Protein details for ZNF91 Gene (UniProtKB/Swiss-Prot)
Protein Symbol:

Q05481-ZNF91_HUMAN

Recommended name:

Zinc finger protein 91

Protein Accession:

Q05481

Secondary Accessions:
- A8K5E1
- B7Z6G6
Protein attributes for ZNF91 Gene
Size:

1191 amino acids

Molecular mass:

137217 Da
Quaternary structure:

No Data Available

Miscellaneous:
ZNF91 is only present in primates and emerged in the last common ancestor of humans and Old-World monkeys. It underwent structural changes between 8-12 Million years ago, probably to improve the proteins ability to bind and repress SINE-VNTR-Alu (SVA) retrotransposons elements (PubMed:25274305).
SequenceCaution:
Sequence=AAA58672.1; Type=Frameshift; Positions=184, 197; Evidence={ECO:0000305};
Alternative splice isoforms for ZNF91 Gene
UniProtKB/Swiss-Prot:
Q05481-1

Q05481-2

neXtProt entry for ZNF91 Gene

Proteomics data for ZNF91 Gene at MOPED

Protein Expression for ZNF91 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for ZNF91 Gene

Modification sites at PhosphoSitePlus
- Q05481
Modification sites at neXtProt
- NX_Q05481

Other Protein References for ZNF91 Gene

ENSEMBL proteins:

REFSEQ proteins:

Antibody Products

Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies

Browse R&D Systems for Antibodies

OriGene Antibodies for ZNF91
- TA342423
- TA342424
Custom Antibody Services

Novus Biologicals Antibodies for ZNF91

Search for Antibodies for ZNF91 at Abcam

Browse Antibodies at Cloud-Clone Corp.

Invitrogen Antibodies for ZNF91

antibodies-online Antibodies for ZNF91: See all 29

Search GeneTex for Antibodies for ZNF91

Search Santa Cruz Biotechnology (SCBT) for ZNF91 Antibodies

Protein Products

Browse Purified and Recombinant Proteins at EMD Millipore

Browse R&D Systems for Human Recombinant Proteins

Browse Enzo Life Sciences for proteins

Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for ZNF91
Origene Custom Protein Services for ZNF91

GenScript Custom Purified and Recombinant Proteins Services for ZNF91

Browse ProSpec Recombinant Proteins

Browse Proteins at Cloud-Clone Corp.

Search eBioscience for ZNF91 related proteins

Search GeneTex for Proteins for ZNF91

Search for Proteins for ZNF91 at Abcam

Assay Products

Browse Kits and Assays available from EMD Millipore

Browse R&D Systems for biochemical assays

GenScript Custom Assay Services for ZNF91

Browse Enzo Life Sciences for kits & assays

Browse Assay Kits at Cloud-Clone Corp.

Search eBioscience for ZNF91 related elisas

Search antibodies-online for kits

Search for Assays for ZNF91 at Abcam

No data available for DME Specific Peptides for ZNF91 Gene

Domains & Families for ZNF91 Gene

Gene Families for ZNF91 Gene

HGNC:

28 : Zinc fingers C2H2-type

Protein Domains for ZNF91 Gene

InterPro:

Blocks:

ProtoNet:

Q05481

Suggested Antigen Peptide Sequences for ZNF91 Gene

GenScript: Design optimal peptide antigens:

Zinc finger protein HTF10 (ZNF91_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q05481

UniProtKB/Swiss-Prot:

ZNF91_HUMAN :

Contains 1 KRAB domain.
Belongs to the krueppel C2H2-type zinc-finger protein family.
Contains 36 C2H2-type zinc fingers.

Domain:

Contains 1 KRAB domain.

Family:

Belongs to the krueppel C2H2-type zinc-finger protein family.

Similarity:

Contains 36 C2H2-type zinc fingers.

Function for ZNF91 Gene

Molecular function for ZNF91 Gene

GENATLAS Biochemistry:

zinc finger protein 91 (HPF7,HTF10),KRAB subfamily,tightly linked to a full size LTR of human endogenous retrovirus HERV-K

ZNF91

UniProtKB/Swiss-Prot Function:

Transcription factor specifically required to repress SINE-VNTR-Alu (SVA) retrotransposons: recognizes and binds SVA sequences and represses their expression by recruiting a repressive complex containing TRIM28/KAP1 (PubMed:25274305). May also bind the promoter of the FCGR2B gene, leading to repress its expression; however, additional evidences are required to confirm this result in vivo (PubMed:11470777).

ZNF91_HUMAN,Q05481

Phenotypes for ZNF91 Gene

GenomeRNAi human phenotypes for ZNF91:

Animal Model Products

Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study

ViGene Biosciences lentiviral particle packaged cDNA for ZNF91 gene
- LH888604
ViGene Biosciences ready-to-package AAV shRNAs for ZNF91 gene
- SH888604
Search ViGene Biosciences for ZNF91

CRISPR Products

OriGene CRISPR knockouts for ZNF91
- KN223098

Santa Cruz Biotechnology (SCBT) CRISPR for ZNF91

GenScript: Design CRISPR guide RNA sequences for ZNF91

miRNA for ZNF91 Gene

miRTarBase miRNAs that target ZNF91

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF91 Gene

Localization for ZNF91 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF91 Gene

Nucleus.

Q05481-ZNF91_HUMAN

Subcellular locations from

COMPARTMENTS

Jensen Localization Image for ZNF91 Gene

Compartment	Confidence
nucleus	5
cytosol	2

No data available for Gene Ontology (GO) - Cellular Components for ZNF91 Gene

Pathways & Interactions for ZNF91 Gene

SuperPathways for ZNF91 Gene

More details on SuperPathways for ZNF91

No Data Available

Interacting Proteins for ZNF91 Gene

http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000300619%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000347184%0d%0a9606.ENSP00000223500%0d%0a9606.ENSP00000385269%0d%0a9606.ENSP00000333982%0d%0a — STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins: ENSP00000300619 Q05481-ZNF91_HUMAN for ZNF91 Gene via STRING I2D

Symbol	External ID(s)	Details
CHMP5	ENSP00000223500 ²⁰ Q9NZZ3 ²¹	STRING: ENSP00000223500 I2D: score=1
MAP4K3	ENSP00000263881 ²⁰ Q8IVH8 ²¹	STRING: ENSP00000263881 I2D: score=2
MEF2C	ENSP00000340874 ²⁰ Q06413 ²¹	STRING: ENSP00000340874 I2D: score=2
NDEL1	ENSP00000333982 ²⁰ Q9GZM8 ²¹	STRING: ENSP00000333982 I2D: score=2
AAK1	ENSP00000386456 ²⁰	STRING: ENSP00000386456

Gene Ontology (GO) - Biological Process for ZNF91 Gene

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0045892	negative regulation of transcription, DNA-templated	IDA	25274305
GO:0070895	negative regulation of transposon integration	IDA	25274305

No data available for Pathways by source and SIGNOR curated interactions for ZNF91 Gene

Drugs & Compounds for ZNF91 Gene

No Compound Related Data Available

Drug Products

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ZNF91

Browse compounds at ApexBio

Transcripts for ZNF91 Gene

mRNA/cDNA for ZNF91 Gene

(5) REFSEQ mRNAs :

(4) Additional mRNA sequences :

(102) Selected AceView cDNA sequences:

(12) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF91 Gene

Zinc finger protein 91:

Hs.654471

Representative Sequences:

NM_003430

CRISPR Products

OriGene CRISPR knockouts for ZNF91
- KN223098

Santa Cruz Biotechnology (SCBT) CRISPR for ZNF91

GenScript: Design CRISPR guide RNA sequences for ZNF91

miRNA Products

Search ViGene Biosciences for ZNF91

SwitchGear ZNF91 3' UTR sequence
Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhibitory RNA Products

Origene RNAi, shRNA, and siRNA products in human, mouse, rat for ZNF91
Browse OriGene Inhibitory RNA Products For ZNF91

ViGene Biosciences ready-to-package AAV shRNAs for ZNF91 gene
- SH888604

Search Santa Cruz Biotechnology (SCBT) for ZNF91 siRNA/shRNA

Clone Products

OriGene clones in human for ZNF91
OriGene ORF clones in human for ZNF91
Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling

GenScript: Next-day shipping cDNA clones in your preferred vector

Browse Sino Biological cDNA Clones

Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat

Search Addgene for plasmids for ZNF91

Flow Cytometry Products

eBioscience FlowRNA Probe Sets

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF91 Gene

No ASD Table

Relevant External Links for ZNF91 Gene

GeneLoc Exon Structure for: ZNF91
ECgene alternative splicing isoforms for: ZNF91

Expression for ZNF91 Gene

mRNA expression in normal human tissues for ZNF91 Gene

mRNA expression by BioGPS for ZNF91 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Brain (Nervous System)
- Pituitary Gland
Adipose (Muscoskeletal System)
- White adipocyte-like cells(Ahfeldt T et. al. 2012)

Protein differential expression in normal tissues from HIPED for ZNF91 Gene

This gene is overexpressed in Plasma (52.2) and Prostate (12.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZNF91 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZNF91 Gene

Integrated proteomics: cell line protein expression from ProteomicsDB, MOPED and MaxQB for ZNF91 Gene

SOURCE GeneReport for Unigene cluster for ZNF91 Gene Hs.654471

Protein tissue co-expression partners for ZNF91 Gene

TMEM79

Primer Products

OriGene qPCR primer pairs for ZNF91
- HP206950

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF91 Gene

Orthologs for ZNF91 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF91 Gene

Organism	Taxonomy	Gene	Similarity	Type	Details
dog (Canis familiaris)	Mammalia	ZNF729 ³⁵	63.98 (n) 53.17 (a)		100685304 XM_005616226.1 XP_005616283.1
dog (Canis familiaris)	Mammalia	-- ³⁶	17 (a)	ManyToMany	1:2976676-3061231
mouse (Mus musculus)	Mammalia	Zfp869 ³⁵	62.95 (n) 54.35 (a)		66869 NM_001039965.1 NP_001035054.1
mouse (Mus musculus)	Mammalia	Zfp869 ¹⁶			69706332
chimpanzee (Pan troglodytes)	Mammalia	ZNF91 ³⁵	99.41 (n) 98.82 (a)		469069 XM_003316240.2 XP_003316288.2
chimpanzee (Pan troglodytes)	Mammalia	ZNF91 ³⁶	99 (a)	OneToOne	19:23360819-23396643
rat (Rattus norvegicus)	Mammalia	Zfp869 ³⁵	58.12 (n) 48.83 (a)		100361114 XM_006252990.1 XP_006253052.1
oppossum (Monodelphis domestica)	Mammalia	-- ³⁶	55 (a)	ManyToMany	4:413329120-413351225
		-- ³⁶	53 (a)	ManyToMany	4:413485281-413510859
		-- ³⁶	55 (a)	ManyToMany	4:413650376-413676069
		-- ³⁶	55 (a)	ManyToMany	Un:43545084-43610158
platypus (Ornithorhynchus anatinus)	Mammalia	-- ³⁶	46 (a)	OneToMany	Contig3143:5383-13391
lizard (Anolis carolinensis)	Reptilia	-- ³⁶	49 (a)	ManyToMany	2:194840020-194915535
		-- ³⁶	40 (a)	ManyToMany	2:195991217-196034905
		-- ³⁶	48 (a)	ManyToMany	2:196185385-196203432
		-- ³⁶	54 (a)	ManyToMany	2:197151657-197186845
		-- ³⁶	50 (a)	ManyToMany	2:197532732-197557744
		-- ³⁶	51 (a)	ManyToMany	2:199024767-199103850
		-- ³⁶	55 (a)	ManyToMany	2:199452678-199472294
		-- ³⁶	51 (a)	ManyToMany	AAWZ02036143:3162-25035
		-- ³⁶	48 (a)	ManyToMany	AAWZ02036528:637-19026
		-- ³⁶	43 (a)	ManyToMany	GL343312.1:1037109-1064987
		-- ³⁶	46 (a)	ManyToMany	GL343312.1:1154756-1203992
		-- ³⁶	47 (a)	ManyToMany	GL343312.1:335814-369088
		-- ³⁶	46 (a)	ManyToMany	GL343312.1:60609-89985
		-- ³⁶	47 (a)	ManyToMany	GL343312.1:704501-722916
		-- ³⁶	46 (a)	ManyToMany	GL343312.1:772275-786659
		-- ³⁶	59 (a)	ManyToMany	GL343434.1:236401-257660
		-- ³⁶	53 (a)	ManyToMany	GL343434.1:478854-492060
		-- ³⁶	51 (a)	ManyToMany	GL343434.1:670616-700655
		-- ³⁶	58 (a)	ManyToMany	GL343434.1:88139-103400
		-- ³⁶	44 (a)	ManyToMany	GL343532.1:13578-48165
		-- ³⁶	46 (a)	ManyToMany	GL343532.1:82185-123726
		-- ³⁶	51 (a)	ManyToMany	GL343538.1:37061-62541
		-- ³⁶	53 (a)	ManyToMany	GL343539.1:448629-458888
		-- ³⁶	53 (a)	ManyToMany	GL343571.1:343652-381239
		-- ³⁶	50 (a)	ManyToMany	GL343575.1:19040-66237
		-- ³⁶	48 (a)	ManyToMany	GL343575.1:377918-402975
		-- ³⁶	56 (a)	ManyToMany	GL343626.1:8361-37913
		-- ³⁶	54 (a)	ManyToMany	GL343658.1:106897-136094
		-- ³⁶	53 (a)	ManyToMany	GL343658.1:66416-82511
		-- ³⁶	54 (a)	ManyToMany	GL343667.1:176729-193915
		-- ³⁶	54 (a)	ManyToMany	GL343667.1:89504-111625
		-- ³⁶	54 (a)	ManyToMany	GL343673.1:117177-138884
		-- ³⁶	58 (a)	ManyToMany	GL343676.1:133636-262720
		-- ³⁶	56 (a)	ManyToMany	GL343676.1:69112-82322
		-- ³⁶	55 (a)	ManyToMany	GL343690.1:26887-41290
		-- ³⁶	56 (a)	ManyToMany	GL343690.1:84834-124121
		-- ³⁶	38 (a)	ManyToMany	GL343713.1:141888-153746
		-- ³⁶	54 (a)	ManyToMany	GL343733.1:125230-159240
		-- ³⁶	55 (a)	ManyToMany	GL343733.1:29820-51787
		-- ³⁶	47 (a)	ManyToMany	GL343771.1:12032-84600
		-- ³⁶	55 (a)	ManyToMany	GL343771.1:40749-72442
		-- ³⁶	54 (a)	ManyToMany	GL343773.1:15895-27886
		-- ³⁶	52 (a)	ManyToMany	GL343775.1:143192-171801
		-- ³⁶	53 (a)	ManyToMany	GL343777.1:150136-185200
		-- ³⁶	57 (a)	ManyToMany	GL343786.1:58917-170574
		-- ³⁶	54 (a)	ManyToMany	GL343924.1:15071-52093
		-- ³⁶	53 (a)	ManyToMany	GL343924.1:27608-81956
		-- ³⁶	55 (a)	ManyToMany	GL343931.1:39051-65856
		-- ³⁶	54 (a)	ManyToMany	GL343934.1:100369-119417
		-- ³⁶	53 (a)	ManyToMany	GL343934.1:30496-57198
		-- ³⁶	50 (a)	ManyToMany	GL343944.1:72047-90252
		-- ³⁶	54 (a)	ManyToMany	GL343955.1:7130-58978
		-- ³⁶	53 (a)	ManyToMany	GL344015.1:54868-85434
		-- ³⁶	56 (a)	ManyToMany	GL344142.1:17782-61632
		-- ³⁶	53 (a)	ManyToMany	GL344187.1:48289-63468
		-- ³⁶	53 (a)	ManyToMany	GL344252.1:3384-46625
		-- ³⁶	52 (a)	ManyToMany	GL344624.1:5323-21578
tropical clawed frog (Silurana tropicalis)	Amphibia	LOC101732856 ³⁵	52.65 (n) 49.54 (a)		101732856 XM_004919570.1 XP_004919627.1
zebrafish (Danio rerio)	Actinopterygii	AL935044.2 ³⁶	47 (a)	ManyToMany	24:16413099-16429687
		BX005085.3 ³⁶	52 (a)	ManyToMany	3:7708389-7743022
		BX321873.2 ³⁶	52 (a)	ManyToMany	5:54168993-54275750
		BX321887.1 ³⁶	45 (a)	ManyToMany	Zv9_scaffold3503:820885-896912
		BX324216.1 ³⁶	43 (a)	ManyToMany	22:10129058-10151007
		BX510909.2 ³⁶	48 (a)	ManyToMany	Zv9_scaffold3560:72844-137635
		BX510909.3 ³⁶	47 (a)	ManyToMany	Zv9_scaffold3560:34047-115165
		BX571760.1 ³⁶	48 (a)	ManyToMany	5:54412566-54549720
		BX942815.1 ³⁶	53 (a)	ManyToMany	8:40886424-40976655
		CABZ01021450.1 ³⁶	45 (a)	ManyToMany	Zv9_scaffold3465:93174-160867
		CABZ01084613.2 ³⁶	45 (a)	ManyToMany	1:59489943-59514625
		CR356223.5 ³⁶	47 (a)	ManyToMany	4:40483555-40572287
		CR847941.1 ³⁶	48 (a)	ManyToMany	5:72786648-72802266
		CR927215.1 ³⁶	50 (a)	ManyToMany	Zv9_scaffold3498:213095-338670
		CU467646.2 ³⁶	45 (a)	ManyToMany	4:61063651-61100204
		CU929391.1 ³⁶	46 (a)	ManyToMany	15:43202165-43212667
		si:ch211-208f21.5 ³⁶	50 (a)	ManyToMany	4:53493980-53618392
		si:ch211-209p16.3 ³⁶	51 (a)	ManyToMany	4:50931905-50985314
		si:ch211-245n8.1 ³⁶	51 (a)	ManyToMany	4:54061582-54100085
		si:ch73-40a17.5 ³⁶	40 (a)	ManyToMany	2:319490-340465
		si:dkey-111k8.1 ³⁶	51 (a)	ManyToMany	3:61960034-61981874
		si:dkey-14o6.6 ³⁶	52 (a)	ManyToMany	4:48718445-48786306
		si:dkey-15h8.4 ³⁶	46 (a)	ManyToMany	22:2991972-3008911
		si:dkey-196n19.7 ³⁶	47 (a)	ManyToMany	4:55819566-55945589
		si:dkey-240n22.7 ³⁶	45 (a)	ManyToMany	4:60992875-61025675
		si:dkey-77f5.7 ³⁶	20 (a)	ManyToMany	15:982635-1009030
		si:dkey-92c21.3 ³⁶	50 (a)	ManyToMany	4:54655500-54685611
		zgc:113100 ³⁶	53 (a)	ManyToMany	3:62866741-62992329
		zgc:113381 ³⁶	42 (a)	ManyToMany	4:58623056-58667327
		zgc:171418 ³⁶	54 (a)	ManyToMany	3:11648176-11681259
		zgc:171570 ³⁶	45 (a)	ManyToMany	2:221432-246482
		zgc:174234 ³⁶	45 (a)	ManyToMany	3:8566034-8627581
fruit fly (Drosophila melanogaster)	Insecta	Aef1 ³⁷	57 (a)
		CG10274 ³⁷	29 (a)
		CG10366 ³⁷	36 (a)
		CG10959 ³⁷	36 (a)
		CG14655 ³⁷	42 (a)
		CG18011 ³⁷	23 (a)
		CG18262 ³⁷	41 (a)
		CG18476 ³⁷	25 (a)
		CG3281 ³⁷	31 (a)
		CG4360 ³⁷	32 (a)
		CG4707 ³⁷	31 (a)
		CG4936 ³⁷	45 (a)
		CG6254 ³⁷	36 (a)
		CG7987 ³⁷	32 (a)
		CG8484 ³⁷	27 (a)
		CG9793 ³⁷	45 (a)
		D19A ³⁷	30 (a)
		D19B ³⁷	30 (a)
		fu2 ³⁷	28 (a)
		grau ³⁷	34 (a)
		l(2)35Ea ³⁷	38 (a)
		Meics ³⁷	40 (a)
		su(Hw) ³⁷	32 (a)
		zf30C ³⁷	28 (a)
		Oaz ³⁶	13 (a)	OneToMany	2R:10323404-10353386
African malaria mosquito (Anopheles gambiae)	Insecta	AgaP_AGAP011262 ³⁵	45.74 (n) 37.82 (a)		1270661 XM_309377.4 XP_309377.4
sea squirt (Ciona savignyi)	Ascidiacea	-- ³⁶	47 (a)	ManyToMany	reftig_131:447752-474163
		-- ³⁶	41 (a)	ManyToMany	reftig_19:774445-791569
		-- ³⁶	45 (a)	ManyToMany	reftig_238:345443-408380
		-- ³⁶	48 (a)	ManyToMany	reftig_249:324773-344406
		-- ³⁶	46 (a)	ManyToMany	reftig_97:391199-417749
		-- ³⁶	48 (a)	ManyToMany	reftig_99:375070-422370
		CSA.11281 ³⁶	42 (a)	ManyToMany	reftig_249:256792-298961

Species with no ortholog for ZNF91:

A. gosspyii yeast (Ashbya gossypii)
Actinobacteria (Mycobacterium tuberculosis)
African clawed frog (Xenopus laevis)
Alicante grape (Vitis vinifera)
alpha proteobacteria (Wolbachia pipientis)
amoeba (Dictyostelium discoideum)
Archea (Pyrococcus horikoshii)
baker's yeast (Saccharomyces cerevisiae)
barley (Hordeum vulgare)
beta proteobacteria (Neisseria meningitidis)
bread mold (Neurospora crassa)
chicken (Gallus gallus)
Chromalveolata (Phytophthora infestans)
common water flea (Daphnia pulex)
corn (Zea mays)
cow (Bos Taurus)
E. coli (Escherichia coli)
filamentous fungi (Aspergillus nidulans)
Firmicute bacteria (Streptococcus pneumoniae)
fission yeast (Schizosaccharomyces pombe)
green algae (Chlamydomonas reinhardtii)
honey bee (Apis mellifera)
K. lactis yeast (Kluyveromyces lactis)
loblloly pine (Pinus taeda)
malaria parasite (Plasmodium falciparum)
medicago trunc (Medicago Truncatula)
moss (Physcomitrella patens)
orangutan (Pongo pygmaeus)
pig (Sus scrofa)
rainbow trout (Oncorhynchus mykiss)
rice (Oryza sativa)
rice blast fungus (Magnaporthe grisea)
schistosome parasite (Schistosoma mansoni)
sea anemone (Nematostella vectensis)
sea urchin (Strongylocentrotus purpuratus)
sorghum (Sorghum bicolor)
soybean (Glycine max)
stem rust fungus (Puccinia graminis)
sugarcane (Saccharum officinarum)
thale cress (Arabidopsis thaliana)
tomato (Lycopersicon esculentum)
toxoplasmosis (Toxoplasma gondii)
Trichoplax (Trichoplax adhaerens)
wheat (Triticum aestivum)
worm (Caenorhabditis elegans)

Evolution for ZNF91 Gene

ENSEMBL:: Gene Tree for ZNF91 (if available)
TreeFam:: Gene Tree for ZNF91 (if available)

Paralogs for ZNF91 Gene

ZNF729 ⁵
ZNF624 ⁵
ZNF268 ⁵
ZNF836 ⁵
ZNF99 ⁵
ZNF594 ⁵
ZNF841 ⁵
ZFP62 ⁵
ZNF585B ⁵
ZNF658 ⁵
ZNF208 ⁵
ZNF845 ⁵
ZNF616 ⁵
ZNF850 ⁵
ZNF721 ⁵

(393) SIMAP similar genes for ZNF91 Gene using alignment to 3 proteins:

Variants for ZNF91 Gene

Sequence variations from dbSNP and Humsavar for ZNF91 Gene

SNP ID	Clin	Chr 19 pos	Sequence Context	Type
rs296091	-	23,362,645(-)	GAAAA(C/T)ATGAA	reference, missense
rs296093	-	23,360,293(-)	CCTCA(A/G)CCCTT	reference, missense
rs440638	-	23,361,616(+)	ATGAA(A/T)TCTTT	reference, missense
rs428549	-	23,359,488(+)	AAAGT(A/G)GTGGG	reference, missense
rs385750	-	23,359,489(-)	TCCCA(C/G)TACTT	reference, missense

Structural Variations from Database of Genomic Variants (DGV) for ZNF91 Gene

Variant ID	Type	Subtype	PubMed ID
esv731	CNV	CNV	17122850
esv2751784	CNV	Gain	17911159
dgv138e55	CNV	Gain	17911159
essv17031	CNV	CNV	17122850
dgv1068e1	CNV	Complex	17122850
nsv9686	CNV	Gain+Loss	18304495
nsv817826	CNV	Gain	17921354
nsv833790	CNV	Gain	17160897
dgv555e201	CNV	Deletion	23290073

Variation tolerance for ZNF91 Gene

Residual Variation Intolerance Score: 77.3% of all genes are more intolerant (likely to be disease-causing)

Gene Damage Index Score: 9.77; 89.47% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ZNF91 Gene

Disorders for ZNF91 Gene

Relevant External Links for ZNF91

Genetic Association Database (GAD): ZNF91
Human Genome Epidemiology (HuGE) Navigator: ZNF91
Atlas of Genetics and Cytogenetics in Oncology and Haematology:: ZNF91

No disorders were found for ZNF91 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF91 Gene

Publications for ZNF91 Gene

The evolutionarily conserved Kruppel-associated box domain defines a subfamily of eukaryotic multifingered proteins. (PMID: 2023909) Bellefroid E.J. … Martial J.A. (Proc. Natl. Acad. Sci. U.S.A. 1991) ² ³ ⁴ ⁶⁷
Clustered organization of homologous KRAB zinc-finger genes with enhanced expression in human T lymphoid cells. (PMID: 8467795) Bellefroid E.J. … Martial J.A. (EMBO J. 1993) ³ ²³
The human genome contains hundreds of genes coding for finger proteins of the Kruppel type. (PMID: 2505992) Bellefroid E.J. … Martial J.A. (DNA 1989) ² ³
A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) ³
An evolutionary arms race between KRAB zinc-finger genes ZNF91/93 and SVA/L1 retrotransposons. (PMID: 25274305) Jacobs F.M. … Haussler D. (Nature 2014) ³