ZNF90 Gene
protein-coding GIFtS : 40
GCID: GC19 P020188
zinc finger protein 90 (Previous name: zinc finger protein 90 (HTF9) )
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Aliasesfor ZNF90 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Zinc Finger Protein 90 1 2 HTF91 2 Zinc Finger Protein HTF92 3 Zinc Finger Protein 90 (HTF9)1
Export aliases for ZNF90 gene to outside databases Previous GC identifers: GC19P020725 GC19P020580 GC19P020034 GC19P020073 GC19P020049 GC19P020076 GC19U900566 GC19P019977
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Summariesfor ZNF90 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section UniProtKB/Swiss-Prot: ZNF90_HUMAN, Q03938 Function : May be involved in transcriptional regulation
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Genomic Viewsfor ZNF90 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000019.9 NC_018930.1 NT_011295.11 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the ZNF90 gene promoter: AML1a FOXO3 Evi-1 FOXO3b COMP1 Cart-1 FOXO1a FOXO3a FOXO1 Other transcription factors Search SABiosciences Chromatin IP Primers for ZNF90 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF90
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 19p12 Ensembl cytogenetic band: 19p12 HGNC cytogenetic band: 19p12 ZNF90 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 19 GeneLoc Exon Structure
GeneLoc location for GC19P020188: view genomic region
(about GC identifiers )
Start:
20,188,803 bp from pter
End:
20,237,885 bp from pter
Size:
49,083 bases
Orientation:
plus strand
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Proteinsfor ZNF90 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: ZNF90_HUMAN, Q03938 (See
protein sequence )Recommended Name: Zinc finger protein 90 Size : 601 amino acids; 69058 Da
Subcellular location : Nucleus (Probable)
Developmental stage : Expressed early during embryonic development
Secondary accessions : B9EH87Explore the universe of human proteins at neXtProt for ZNF90: NX_Q03938 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q03938 ZNF90 Protein expression data from MOPED and PaxDb : --REFSEQ proteins: NP_009069.1 ENSEMBL proteins: ENSP00000420111 ENSP00000418166 ENSP00000410466 Human Recombinant Protein Products: Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view) : About this table
ZNF90 for ontologies About GeneDecksing ZNF90 Antibody Products: Assay Products for ZNF90:
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Protein
Domains / Familiesfor ZNF90 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
ZNF90 for domains About GeneDecksing 4 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry Q03938 ProtoNet protein and cluster: Q03938
1 Blocks protein family : IPB001909 KRAB box UniProtKB/Swiss-Prot: ZNF90_HUMAN, Q03938 Similarity : Belongs to the krueppel C2H2-type zinc-finger protein familySimilarity : Contains 15 C2H2-type zinc fingersSimilarity : Contains 1 KRAB domain
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Functionfor ZNF90 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: ZNF90_HUMAN, Q03938 Function : May be involved in transcriptional regulation
Genatlas biochemistry entry for ZNF90 : zinc finger protein 90 (HTF9),KRAB subfamily Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for ZNF90 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for ZNF90OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: ZNF90 (NM_007138 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF90 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat ZNF90
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view) : About this table
ZNF90 for ontologies About GeneDecksing
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Pathways & Interactionsfor ZNF90 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF90 Gene Ontology (GO): 2 biological process terms (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0006351 transcription, DNA-dependent
IEA -- GO:0006355 regulation of transcription, DNA-dependent
NAS --
ZNF90 for ontologies About GeneDecksing
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Drugs & Compoundsfor ZNF90 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for ZNF90 Search CenterWatch for drugs/clinical trials and news about ZNF90
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Transcriptsfor ZNF90 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
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Primers from
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QIAGEN
)About This Section REFSEQ mRNAs for ZNF90 gene: NM_007138.1 Unigene Cluster for ZNF90:
Zinc finger protein 90 Hs.55304 [show with all ESTs ] Unigene Representative Sequence: NM_007138 6 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000469078 ENST00000474284 (uc021url.1 ) ENST00000473524 ENST00000418063 (uc002nor.2 )ENST00000492328 ENST00000484032 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for ZNF90 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for ZNF90OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: ZNF90 (NM_007138 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF90 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat ZNF90
Additional cDNA sequence: AK298173.1 BC137211.1 M61870.1
15 DOTS entries : DT.99995515 DT.91744579
DT.99972817 DT.91640964 DT.91722009 DT.100020145 DT.100804400 DT.40316414 DT.433029 DT.439064 DT.450351 DT.91917593 DT.95100464 DT.95150319 DT.97858455 GeneLoc Exon Structure
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Expression for ZNF90 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section ZNF90 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: ATGAAAATAT
About this image ZNF90 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table Stem Cell Differentiation: 1 LifeMap Cell Name Category Definitive endoderm-like cells (A scalable, suspensi... )Expression: Positive Negative
Selective markerExperimental details:
Curated
Microarrays
In-situ hybridization
Genevestigator expression for ZNF90 SOURCE GeneReport for Unigene cluster: Hs.55304 SABiosciences Custom PCR Arrays for ZNF90 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for ZNF90Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse / rat ZNF90 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat ZNF90 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat ZNF90
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Orthologsfor ZNF90 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of chordates.
Orthologs for ZNF90 gene from 1/7 species (see all 7 ) About this table
ENSEMBL Gene Tree for ZNF90 (if available)TreeFam Gene Tree for ZNF90 (if available)
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Paralogsfor ZNF90 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for ZNF90 gene ZNF85 2 ZNF493 2 ZNF486 2 ZNF100 2 ZNF92 2 ZNF732 2 ZNF138 2 ZNF675 2 ZNF506 2 ZNF273 2 ZNF66P 2 ZNF695 2 ZNF626 2 ZNF680 2 ZNF253 2 ZNF479 2 ZNF93 2 ZNF492 2 ZNF682 2 ZNF676 2 ZNF141 2 ZNF681 2 ZNF679 2 ZNF257 2 ZNF254 2 ZNF737 2 ZNF724P 2 ZNF98 2 ZNF849P 2 ZNF716 2 ZNF714 2 ZNF429 2 ZNF430 2 ZNF730 2 ZNF678 2 ZNF708 2 ZNF117 2 ZNF107 2 ZNF431 2 18/505 SIMAP similar genes for ZNF90 using alignment to 3 protein entries: ZNF90_HUMAN (see all proteins )
(see all similar genes ):ZNF506 MGC12518 ZNF93 ZNF66 ZNF66P ZNF273 ZNF726 ZNF85 ZNF430 ZNF420 ZFS-4 ZFS-6 ZNF738 ZNF729 ZNF737 ZNF624 ZFP90 ZNF254
ZNF90 for paralogs About GeneDecksing 5/6 Pseudogenes.org Pseudogenes for ZNF90 (see all 6 )PGOHUM00000259306 PGOHUM00000259311 PGOHUM00000262381 PGOHUM00000262383 PGOHUM00000234564
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Genomic Variantsfor ZNF90 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 19 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for ZNF90 (20188803 - 20237885 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 4 variations for ZNF90 4 CNVs : 9789 3182 8865 4069
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing ZNF90
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Disorders
/ Diseasesfor ZNF90 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
ZNF90 for disorders About MalaCards
ZNF90 for disorders About GeneDecksing
OMIM gene information: 603973
OMIM disorders : --Export disorders for ZNF90 gene to outside databases
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Publicationsfor ZNF90 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for ZNF90 gene integrated from 9 sources : (articles sorted by number of sources associating them with ZNF90) Utopia : connect your pdf to the dynamic world of online information
Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PubMed id 15146197) 1 , 2 Brandenberger R.... Stanton L.W. (2004) Clustered organization of homologous KRAB zinc-finger genes with enhanced expression in human T lymphoid cells. (PubMed id 8467795) 1 , 3 Bellefroid E.J.... Martial J.A. (1993) The evolutionarily conserved Kruppel-associated box domain defines a subfamily of eukaryotic multifingered proteins. (PubMed id 2023909) 1 , 2 Bellefroid E.J....Martial J.A. (1991) Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724) 1 Udeshi N.D....Carr S.A. (2012) Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348) 1 Barbe L....Andersson-Svahn H. (2008) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 2 Gerhard D.S....Malek J. (2004) The DNA sequence and biology of human chromosome 19. (PubMed id 15057824) 2 Grimwood J.... Lucas S.M. (2004) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 Strausberg R.L....Marra M.A. (2002) The sequence of the human genome. (PubMed id 11181995) 1 Venter J.C.... Zhu X. (2001)
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External Searches for ZNF90 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing ZNF90 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing ZNF90 gene
(According to HUGE )
About This Section --
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Specialized Databases showing ZNF90 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for ZNF90 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for ZNF90 gene: Search GeneIP for patents involving ZNF90 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor ZNF90 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for ZNF90 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for ZNF90 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for ZNF90 Browse OriGene Protein Over-expression Lysates Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for ZNF90 OriGene 3'-UTR Clone for ZNF90 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for ZNF90 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for ZNF90 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for ZNF90 OriGene Custom Protein Services for ZNF90 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ZNF90 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing ZNF90 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF90 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat ZNF90 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat ZNF90 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat ZNF90
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Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat ZNF90
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