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Aliases for ZNF891 Gene

Aliases for ZNF891 Gene

  • Zinc Finger Protein 891 2 3 5
  • HCG1646157 3

External Ids for ZNF891 Gene

Previous GeneCards Identifiers for ZNF891 Gene

  • GC12M133698
  • GC12M130476

Summaries for ZNF891 Gene

GeneCards Summary for ZNF891 Gene

ZNF891 (Zinc Finger Protein 891) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF333.

UniProtKB/Swiss-Prot for ZNF891 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF891 Gene

Genomics for ZNF891 Gene

Regulatory Elements for ZNF891 Gene

Enhancers for ZNF891 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12F133180 0.2 ENCODE 46.5 -51.1 -51116 1.5 CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 CBX5 ZNF207 ZNF143 ZNF891 ZNF140 ZNF268 ZNF10 ENSG00000256825 GOLGA3 ZNF84 ENSG00000255919
GH12F132487 1.6 FANTOM5 Ensembl ENCODE 40.5 +631.1 631124 23.9 HDGF PKNOX1 ARNT CREB3L1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZNF26 EP400NL ZNF891 FBRSL1 EP400 ZNF10 GOLGA3 NOC4L ENSG00000256875 ZNF84
GH12F133129 0.2 ENCODE 33.2 +0.1 78 2.3 PKNOX1 ARNT CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 CBX5 ZNF891 ZNF10 ZNF84 ZNF605 ZNF140 ZNF268 ENSG00000250790 GOLGA3 DDX51 RPL23AP67
GH12F132827 0.5 ENCODE 23 +302.0 301991 2.6 PKNOX1 ARNT CREB3L1 MLX WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ANKLE2 ZNF26 ZNF891 ZNF140 EP400 ZNF10 ENSG00000255919 PUS1 ZNF84 NOC4L
GH12F132954 1 ENCODE 21.7 +174.7 174737 2.4 ATF1 ARID4B SIN3A DMAP1 ZNF2 YY1 ETS1 GLIS2 CBX5 ZNF143 ZNF84 ZNF891 ENSG00000250790 ZNF140 DDX51 LOC101928597 ENSG00000256825 ZNF10 ZNF268 ZNF26
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ZNF891 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF891 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000092102 72 2799 PKNOX1 ARNT CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 CBX5

Genomic Location for ZNF891 Gene

Chromosome:
12
Start:
133,106,817 bp from pter
End:
133,130,473 bp from pter
Size:
23,657 bases
Orientation:
Minus strand

Genomic View for ZNF891 Gene

Genes around ZNF891 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF891 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF891 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF891 Gene

Proteins for ZNF891 Gene

  • Protein details for ZNF891 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A8MT65-ZN891_HUMAN
    Recommended name:
    Zinc finger protein 891
    Protein Accession:
    A8MT65

    Protein attributes for ZNF891 Gene

    Size:
    544 amino acids
    Molecular mass:
    63592 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BC017932; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

neXtProt entry for ZNF891 Gene

Post-translational modifications for ZNF891 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF891 Gene

No data available for DME Specific Peptides for ZNF891 Gene

Domains & Families for ZNF891 Gene

Gene Families for ZNF891 Gene

Protein Domains for ZNF891 Gene

Suggested Antigen Peptide Sequences for ZNF891 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A8MT65

UniProtKB/Swiss-Prot:

ZN891_HUMAN :
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 8 C2H2-type zinc fingers.
Domain:
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 8 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF891: view

Function for ZNF891 Gene

Molecular function for ZNF891 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF891 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF891: view

Phenotypes for ZNF891 Gene

genes like me logo Genes that share phenotypes with ZNF891: view

Animal Model Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF891 Gene

Localization for ZNF891 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF891 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF891 Gene COMPARTMENTS Subcellular localization image for ZNF891 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF891 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF891: view

Pathways & Interactions for ZNF891 Gene

SuperPathways for ZNF891 Gene

No Data Available

Interacting Proteins for ZNF891 Gene

Selected Interacting proteins: A8MT65-ZN891_HUMAN for ZNF891 Gene via IID

Symbol External ID(s) Details
PSME3

Gene Ontology (GO) - Biological Process for ZNF891 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF891: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF891 Gene

Transcripts for ZNF891 Gene

mRNA/cDNA for ZNF891 Gene

(4) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF891 Gene

No ASD Table

Relevant External Links for ZNF891 Gene

GeneLoc Exon Structure for
ZNF891
ECgene alternative splicing isoforms for
ZNF891

Expression for ZNF891 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF891 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZNF891 Gene



NURSA nuclear receptor signaling pathways regulating expression of ZNF891 Gene:

ZNF891
genes like me logo Genes that share expression patterns with ZNF891: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for ZNF891 Gene

Orthologs for ZNF891 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF891 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC100610530 34
  • 99.51 (n)
ZNF891 35
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia LOC100125388 34
  • 82 (n)
ZNF891 35
  • 40 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 47 (a)
ManyToMany
-- 35
  • 41 (a)
ManyToMany
-- 35
  • 40 (a)
ManyToMany
-- 35
  • 33 (a)
ManyToMany
-- 35
  • 33 (a)
ManyToMany
-- 35
  • 31 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia 2410141K09Rik 35
  • 35 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 27 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii ZNF557 35
  • 21 (a)
OneToMany
Species where no ortholog for ZNF891 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF891 Gene

ENSEMBL:
Gene Tree for ZNF891 (if available)
TreeFam:
Gene Tree for ZNF891 (if available)

Paralogs for ZNF891 Gene

Paralogs for ZNF891 Gene

(461) SIMAP similar genes for ZNF891 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ZNF891: view

Variants for ZNF891 Gene

Sequence variations from dbSNP and Humsavar for ZNF891 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1011481 -- 133,125,140(-) TTTCC(A/G)TTTTC intron-variant
rs10593642 -- 133,117,965(+) TTTTT(-/T)GAGAT utr-variant-3-prime
rs10711540 -- 133,125,184(+) TTTTT(-/A)GAGAC intron-variant
rs10747096 -- 133,128,077(+) GATGT(A/G)GAAAG intron-variant
rs10870580 -- 133,119,266(+) Tggcc(A/G)ggcac utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ZNF891 Gene

Variant ID Type Subtype PubMed ID
dgv1590n100 CNV gain 25217958
dgv1592n100 CNV gain 25217958
dgv1593n100 CNV gain 25217958
dgv1594n100 CNV gain 25217958
dgv1595n100 CNV gain 25217958
dgv1596n100 CNV gain 25217958
dgv220n27 CNV gain 19166990
dgv3060n54 CNV gain 21841781
dgv534e212 CNV gain 25503493
esv27162 CNV gain+loss 19812545
esv2759923 CNV loss 17122850
esv2760921 CNV gain 21179565
esv2763014 CNV gain 21179565
esv3631326 CNV loss 21293372
esv3631327 CNV gain 21293372
esv3631328 CNV gain 21293372
nsv1054203 CNV gain 25217958
nsv455818 CNV loss 19166990
nsv470337 CNV loss 18288195
nsv518970 CNV gain 19592680
nsv561145 CNV gain 21841781
nsv561148 CNV loss 21841781
nsv975544 CNV duplication 23825009

Variation tolerance for ZNF891 Gene

Gene Damage Index Score: 7.20; 80.95% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF891 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF891

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF891 Gene

Disorders for ZNF891 Gene

Relevant External Links for ZNF891

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF891

No disorders were found for ZNF891 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF891 Gene

Publications for ZNF891 Gene

  1. The finished DNA sequence of human chromosome 12. (PMID: 16541075) Scherer S.E. … Gibbs R.A. (Nature 2006) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 64
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for ZNF891 Gene

Sources for ZNF891 Gene

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