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Aliases for ZNF891 Gene

Aliases for ZNF891 Gene

  • Zinc Finger Protein 891 2 3 5
  • HCG1646157 3

External Ids for ZNF891 Gene

Previous GeneCards Identifiers for ZNF891 Gene

  • GC12M133698
  • GC12M130476

Summaries for ZNF891 Gene

GeneCards Summary for ZNF891 Gene

ZNF891 (Zinc Finger Protein 891) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF559-ZNF177.

UniProtKB/Swiss-Prot for ZNF891 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF891 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF891 Gene

Genomics for ZNF891 Gene

GeneHancer (GH) Regulatory Elements for ZNF891 Gene

Promoters and enhancers for ZNF891 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12I133129 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 583.2 0.0 -28 2.6 PKNOX1 CLOCK ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 SLC30A9 ZNF891 ZNF10 ENSG00000256825 ZNF84 DDX51 ZNF605 ZNF268 ZNF140 CHFR ENSG00000250790
GH12I132597 Enhancer 1.2 Ensembl ENCODE 147.1 +532.2 532159 1.8 HDGF ARNT YBX1 ZNF2 ZNF143 ZNF548 SP3 ZNF662 REST ZNF592 ZNF140 EP400 ZNF84 ZNF268 ZNF891 ZNF26 GOLGA3 ZNF605 ANKLE2 DDX51
GH12I133180 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 46.5 -51.3 -51255 1.7 ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B ZNF766 ZNF213 E2F8 ZNF207 ZNF268 ZNF891 ZNF140 ENSG00000256825 ZNF10 CHFR ZNF26 ENSG00000255919
GH12I132827 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 41 +302.0 301990 2.6 PKNOX1 CLOCK SMAD1 MLX ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 GOLGA3 ANKLE2 ZNF140 ZNF26 EP400 NOC4L CHFR ZNF891 POLE ZNF268
GH12I132886 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 34.2 +242.5 242471 3.2 HDGF PKNOX1 CLOCK SMAD1 ARID4B SIN3A DMAP1 ZNF2 YY1 CBX5 CHFR LOC101928530 ZNF140 ANKLE2 EP400 ZNF26 ZNF891 EP400P1 GOLGA3 ZNF268
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF891 on UCSC Golden Path with GeneCards custom track

Genomic Locations for ZNF891 Gene

Genomic Locations for ZNF891 Gene
chr12:133,106,817-133,130,473
(GRCh38/hg38)
Size:
23,657 bases
Orientation:
Minus strand
chr12:133,694,740-133,707,059
(GRCh37/hg19)

Genomic View for ZNF891 Gene

Genes around ZNF891 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF891 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF891 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF891 Gene

Proteins for ZNF891 Gene

  • Protein details for ZNF891 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A8MT65-ZN891_HUMAN
    Recommended name:
    Zinc finger protein 891
    Protein Accession:
    A8MT65

    Protein attributes for ZNF891 Gene

    Size:
    544 amino acids
    Molecular mass:
    63592 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BC017932; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

neXtProt entry for ZNF891 Gene

Post-translational modifications for ZNF891 Gene

No Post-translational modifications

Other Protein References for ZNF891 Gene

No data available for DME Specific Peptides for ZNF891 Gene

Domains & Families for ZNF891 Gene

Gene Families for ZNF891 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF891 Gene

Suggested Antigen Peptide Sequences for ZNF891 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A8MT65

UniProtKB/Swiss-Prot:

ZN891_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF891: view

Function for ZNF891 Gene

Molecular function for ZNF891 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF891 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF891: view

Phenotypes for ZNF891 Gene

genes like me logo Genes that share phenotypes with ZNF891: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF891 Gene

Localization for ZNF891 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF891 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF891 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF891 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF891: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ZNF891 Gene

Pathways & Interactions for ZNF891 Gene

SuperPathways for ZNF891 Gene

No Data Available

Interacting Proteins for ZNF891 Gene

Selected Interacting proteins: A8MT65-ZN891_HUMAN for ZNF891 Gene via IID

Symbol External ID(s) Details
PSME3

Gene Ontology (GO) - Biological Process for ZNF891 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF891: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF891 Gene

Drugs & Compounds for ZNF891 Gene

No Compound Related Data Available

Transcripts for ZNF891 Gene

mRNA/cDNA for ZNF891 Gene

(4) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF891 Gene

No ASD Table

Relevant External Links for ZNF891 Gene

GeneLoc Exon Structure for
ZNF891
ECgene alternative splicing isoforms for
ZNF891

Expression for ZNF891 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF891 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZNF891 Gene



NURSA nuclear receptor signaling pathways regulating expression of ZNF891 Gene:

ZNF891
genes like me logo Genes that share expression patterns with ZNF891: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF891 Gene

Orthologs for ZNF891 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF891 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC100610530 33
  • 99.51 (n)
ZNF891 34
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia LOC100125388 33
  • 82 (n)
ZNF891 34
  • 40 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 47 (a)
ManyToMany
-- 34
  • 41 (a)
ManyToMany
-- 34
  • 40 (a)
ManyToMany
-- 34
  • 33 (a)
ManyToMany
-- 34
  • 33 (a)
ManyToMany
-- 34
  • 31 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia 2410141K09Rik 34
  • 35 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 27 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii ZNF557 34
  • 21 (a)
OneToMany
Species where no ortholog for ZNF891 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF891 Gene

ENSEMBL:
Gene Tree for ZNF891 (if available)
TreeFam:
Gene Tree for ZNF891 (if available)

Paralogs for ZNF891 Gene

Paralogs for ZNF891 Gene

(461) SIMAP similar genes for ZNF891 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ZNF891: view

Variants for ZNF891 Gene

Sequence variations from dbSNP and Humsavar for ZNF891 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000033140 -- 133,125,116(-) G/T genic_upstream_transcript_variant, intron_variant
rs1000047427 -- 133,131,471(-) TACTGTTA/TA upstream_transcript_variant
rs1000080748 -- 133,130,706(-) T/G upstream_transcript_variant
rs1000134559 -- 133,130,550(-) A/C upstream_transcript_variant
rs1000572596 -- 133,125,858(-) A/G genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF891 Gene

Variant ID Type Subtype PubMed ID
dgv1590n100 CNV gain 25217958
dgv1592n100 CNV gain 25217958
dgv1593n100 CNV gain 25217958
dgv1594n100 CNV gain 25217958
dgv1595n100 CNV gain 25217958
dgv1596n100 CNV gain 25217958
dgv220n27 CNV gain 19166990
dgv3060n54 CNV gain 21841781
dgv534e212 CNV gain 25503493
esv27162 CNV gain+loss 19812545
esv2759923 CNV loss 17122850
esv2760921 CNV gain 21179565
esv2763014 CNV gain 21179565
esv3631326 CNV loss 21293372
esv3631327 CNV gain 21293372
esv3631328 CNV gain 21293372
nsv1054203 CNV gain 25217958
nsv455818 CNV loss 19166990
nsv470337 CNV loss 18288195
nsv518970 CNV gain 19592680
nsv561145 CNV gain 21841781
nsv561148 CNV loss 21841781
nsv975544 CNV duplication 23825009

Variation tolerance for ZNF891 Gene

Gene Damage Index Score: 7.20; 80.95% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF891 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF891

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF891 Gene

Disorders for ZNF891 Gene

Additional Disease Information for ZNF891

No disorders were found for ZNF891 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF891 Gene

Publications for ZNF891 Gene

  1. The finished DNA sequence of human chromosome 12. (PMID: 16541075) Scherer SE … Baylor College of Medicine Human Genome Sequencing Center Sequence Production Team (Nature 2006) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 58

Products for ZNF891 Gene

Sources for ZNF891 Gene

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