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Aliases for ZNF888 Gene

Aliases for ZNF888 Gene

  • Zinc Finger Protein 888 2 3 5
  • CTD-2331H12.6 3

External Ids for ZNF888 Gene

Previous GeneCards Identifiers for ZNF888 Gene

  • GC19M053410

Summaries for ZNF888 Gene

GeneCards Summary for ZNF888 Gene

ZNF888 (Zinc Finger Protein 888) is a Protein Coding gene.

UniProtKB/Swiss-Prot for ZNF888 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF888 Gene

Genomics for ZNF888 Gene

Regulatory Elements for ZNF888 Gene

Enhancers for ZNF888 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F053364 0.5 ENCODE 10.8 -442.2 -442221 1.6 HDGF CREB3L1 ZFP64 ARID4B SIN3A DMAP1 KLF13 ZNF263 SP3 REST ZNF525 ZNF808 ZNF845 ENSG00000268970 ZNF137P ZNF765 ZNF816 ENSG00000269825 ZNF813 TPM3P6
GH19F053389 0.2 ENCODE 10.8 -466.5 -466459 1.8 KLF1 SUZ12 CREB3L1 ZNF76 DEAF1 DIDO1 ZNF766 ZNF366 POLR2A ZNF143 ZNF808 ZNF765 ZNF525 ZNF813 ENSG00000268970 ZNF845 ZNF137P ZNF816 ENSG00000269825 TPM3P6
GH19F053864 1 FANTOM5 ENCODE 10.8 -945.4 -945445 9.8 PKNOX1 CREB3L1 MLX ZFP64 ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF766 ZNF845 ZNF765 ZNF816 ENSG00000235681 ZNF813 TPM3P6 LENG8-AS1 MYADM ZNF525 ZNF665
GH19F052137 1.3 FANTOM5 ENCODE 10.8 +783.8 783839 3.3 PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 YY1 ZNF143 FOS ZNF808 ZNF137P ENSG00000268970 ZNF816 ZNF350 ZNF836 ZNF600 ZNF468 ZNF616 ZNF841
GH19F053893 0.2 ENCODE 10.8 -969.7 -969712 0.2 SUZ12 CREB3L1 HCFC1 ZBTB11 ZNF76 DEAF1 SIX5 ZEB2 ETS1 MBD2 ZNF765 CDC42EP5 ZNF813 ZNF845 ZNF816 ENSG00000235681 TPM3P6 LENG8-AS1 ZNF525 ZNF665
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ZNF888 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF888 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001420036 170 2201 ATF1 WRNIP1 ARID4B SIN3A BRCA1 ELK1 ZNF207 SP3 ETV4 NBN

Genomic Location for ZNF888 Gene

Chromosome:
19
Start:
52,905,893 bp from pter
End:
52,923,470 bp from pter
Size:
17,578 bases
Orientation:
Minus strand

Genomic View for ZNF888 Gene

Genes around ZNF888 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF888 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF888 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF888 Gene

Proteins for ZNF888 Gene

  • Protein details for ZNF888 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0CJ79-ZN888_HUMAN
    Recommended name:
    Zinc finger protein 888
    Protein Accession:
    P0CJ79

    Protein attributes for ZNF888 Gene

    Size:
    500 amino acids
    Molecular mass:
    58727 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF888 Gene

Post-translational modifications for ZNF888 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF888 Gene

No data available for DME Specific Peptides for ZNF888 Gene

Domains & Families for ZNF888 Gene

Gene Families for ZNF888 Gene

Protein Domains for ZNF888 Gene

Suggested Antigen Peptide Sequences for ZNF888 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P0CJ79

UniProtKB/Swiss-Prot:

ZN888_HUMAN :
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 12 C2H2-type zinc fingers.
Domain:
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 12 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF888: view

Function for ZNF888 Gene

Molecular function for ZNF888 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF888 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF888: view

Phenotypes for ZNF888 Gene

GenomeRNAi human phenotypes for ZNF888:
genes like me logo Genes that share phenotypes with ZNF888: view

Animal Model Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZNF888 Gene

Localization for ZNF888 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF888 Gene

Gene Ontology (GO) - Cellular Components for ZNF888 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF888: view

No data available for Subcellular locations from COMPARTMENTS for ZNF888 Gene

Pathways & Interactions for ZNF888 Gene

SuperPathways for ZNF888 Gene

No Data Available

Interacting Proteins for ZNF888 Gene

Gene Ontology (GO) - Biological Process for ZNF888 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA --
genes like me logo Genes that share ontologies with ZNF888: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF888 Gene

Transcripts for ZNF888 Gene

mRNA/cDNA for ZNF888 Gene

(5) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF888 Gene

No ASD Table

Relevant External Links for ZNF888 Gene

GeneLoc Exon Structure for
ZNF888
ECgene alternative splicing isoforms for
ZNF888

Expression for ZNF888 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF888 Gene

mRNA differential expression in normal tissues according to GTEx for ZNF888 Gene

This gene is overexpressed in Bladder (x7.3).

Protein differential expression in normal tissues from HIPED for ZNF888 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (52.8) and Amniocyte (16.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF888 Gene



Protein tissue co-expression partners for ZNF888 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF888 Gene:

ZNF888
genes like me logo Genes that share expression patterns with ZNF888: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for ZNF888 Gene

Orthologs for ZNF888 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for ZNF888 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC456268 34
  • 95.44 (n)
Species where no ortholog for ZNF888 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF888 Gene

ENSEMBL:
Gene Tree for ZNF888 (if available)
TreeFam:
Gene Tree for ZNF888 (if available)

Paralogs for ZNF888 Gene

(539) SIMAP similar genes for ZNF888 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ZNF888: view

No data available for Paralogs for ZNF888 Gene

Variants for ZNF888 Gene

Sequence variations from dbSNP and Humsavar for ZNF888 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10401262 -- 52,917,943(+) AAGTC(A/G)ATCAT intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs10402041 -- 52,910,797(+) ccagt(G/T)taagc intron-variant
rs10404213 -- 52,926,918(+) cacca(C/T)gcctg intron-variant, downstream-variant-500B
rs10404660 -- 52,927,109(+) ATAGC(C/T)ttttt intron-variant, downstream-variant-500B
rs10406306 -- 52,915,365(+) AGGAG(A/T)TCTTA intron-variant

Relevant External Links for ZNF888 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF888

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for ZNF888 Gene

Disorders for ZNF888 Gene

Relevant External Links for ZNF888

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF888

No disorders were found for ZNF888 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF888 Gene

Publications for ZNF888 Gene

  1. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 3 4 64

Products for ZNF888 Gene

Sources for ZNF888 Gene

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