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ZNF883 Gene

protein-coding   GIFtS: 35
GCID: GC09M115760

Zinc Finger Protein 883

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger Protein 8831 2

External Ids:    HGNC: 272711   Entrez Gene: 1698342   Ensembl: ENSG000002286237   UniProtKB: P0CG243   

Export aliases for ZNF883 gene to outside databases

Previous GC identifer: GC09M085357


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZNF883 Gene:
ZNF883 (zinc finger protein 883) is a protein-coding gene.

UniProtKB/Swiss-Prot: ZN883_HUMAN, P0CG24
Function: May be involved in transcriptional regulation (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000009.11  NC_018920.2  NT_008470.20  
Regulatory elements:
   Search for regulatory transcription factor binding sites for ZNF883
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for ZNF883

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF883


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q32   Ensembl cytogenetic band:  9q32   HGNC cytogenetic band: 9q32

ZNF883 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF883 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M115760:  view genomic region     (about GC identifiers)

Start:
115,759,400 bp from pter      End:
115,774,507 bp from pter
Size:
15,108 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ZN883_HUMAN, P0CG24 (See protein sequence)
Recommended Name: Zinc finger protein 883  
Size: 379 amino acids; 43967 Da

Explore the universe of human proteins at neXtProt for ZNF883: NX_P0CG24

Post-translational modifications: 

  • Ubiquitination2 at Lys67
  • Modification sites at PhosphoSitePlus
  • REFSEQ proteins: NP_001094808.1  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    3 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry P0CG24

    ProtoNet protein and cluster: P0CG24

    UniProtKB/Swiss-Prot: ZN883_HUMAN, P0CG24
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 13 C2H2-type zinc fingers


    Find genes that share domains with ZNF883           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN883_HUMAN, P0CG24
    Function: May be involved in transcriptional regulation (By similarity)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with ZNF883           About GenesLikeMe


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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZN883_HUMAN, P0CG24: Nucleus (By similarity)

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    Find genes that share ontologies with ZNF883           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF883
    Interactions:

        Search GeneGlobe Interaction Network for ZNF883

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--

    Find genes that share ontologies with ZNF883           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for ZNF883 (ZN883)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ZNF883 gene: 
    NM_001101338.1  

    Unigene Cluster for ZNF883:

    Zinc finger protein 883
    Hs.192877  [show with all ESTs]
    Unigene Representative Sequence: NM_001101338
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000427548(lincRNA)(uc011lwy.2)
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    Additional mRNA sequence: AK095843.1 

    2 DOTS entries:

    DT.409919  DT.91717898 

    Selected AceView cDNA sequences (see all 46):

    AA460054 AK095843 CR602666 AA459964 BU681651 AI382946 AI379325 BE670938 
    AA176490 BX498615 AA211186 AI423463 AI352101 AI278275 AA442436 BE222323 
    BX410054 BU187906 AA779668 AW183146 AA176763 BU738164 AI827906 BF445116 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZNF883 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGAAAGGCC
    ZNF883 Expression
    About this image

    ZNF883 Protein expression data from MOPED1, PaxDb2 and MaxQB3 --

    SOURCE GeneReport for Unigene cluster: Hs.192877
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and chimp.

    Orthologs for ZNF883 gene from 1 species (see representative species )    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chimpanzee
    (Pan troglodytes)
    Mammalia ZNF8831 zinc finger protein 883 98.42(n)
    97.36(a)
      100610156  XM_003312217.2  XP_003312265.2 


    ENSEMBL Gene Tree for ZNF883 (if available)
    TreeFam Gene Tree for ZNF883 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZNF883 gene
    Selected SIMAP similar genes for ZNF883 using alignment to 1 protein entry:     ZN883_HUMAN(see all similar genes):
    ZNF818P    ZNF78L1    ZNF3    DKFZp686N14223    ZNF286A    ZFS-4
    ZNF232    ZNF286B    DKFZp313M0722    DKFZp547L155    DKFZp666C237    ZNF132
    ZNF16    ZNF22    ZNF323    ZNF485    ZNF56    ZNF

    Find genes that share paralogs with ZNF883           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZNF883 (see all 363)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1932474141,2
    --115758944(+) CGGGCA/GCCTGT 1 -- ds50010--------
    rs1404117311,2
    --115758987(+) AATGGC/TGTGAA 1 -- ds50010--------
    rs19648801,2
    A--115759057(+) cagagC/Tgagac 1 -- ds50011Minor allele frequency- T:0.00NA 2
    rs563503731,2
    --115759059(+) GAGCGA/GGACTC 1 -- ds50010--------
    rs1485531501,2
    --115759112(+) TTTTT-/AAAATAAG 1 -- cds10--------
    rs1464300931,2
    --115759331(+) CTAGGC/GTTGCT 1 -- ds50010--------
    rs1850648351,2
    C--115759372(+) ACCTAC/TGACTG 1 -- ds50010--------
    rs1166126851,2
    C,F--115759443(+) GATGTC/G/TGAATT 3 Q P R mis11WA 118
    rs37398401,2
    C,H--115759468(+) ACAAAA/TGACAT 2 I F mis16Minor allele frequency- T:0.01EA NS NA 1904
    rs3762318611,2
    C--115759518(+) GTATTC/TGCTTA 2 Q R mis10--------

    HapMap Linkage Disequilibrium report for ZNF883 (115759400 - 115774507 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for ZNF883:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv466490CNV Loss19166990
    nsv831691CNV Loss17160897
    nsv466491CNV Loss19166990
    nsv825050CNV Gain20364138
    dgv2412e1CNV Complex17122850

    Human Gene Mutation Database (HGMD): ZNF883
    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with ZNF883           About GenesLikeMe


    Export disorders for ZNF883 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZNF883 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with ZNF883)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (Nature 2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 169834 HGNC: 27271 AceView: LOC169834 Ensembl:ENSG00000228623 euGenes: HUgn169834
    ECgene: ZNF883 H-InvDB: ZNF883

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZNF883 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZNF883 gene:
    Search GeneIP for patents involving ZNF883

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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     Browse SwitchGear Promoter luciferase reporter plasmids for ZNF883
     Search ThermoFisher Antibodies for ZNF883
     Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat ZNF883
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ZNF883
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ZNF883
     LSBio Antibodies in human, mouse, rat for ZNF883
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     Browse compounds at ApexBio
     Search Addgene for plasmids for ZNF883
      Search eBioscience for proteins for ZNF883
      Search eBioscience for elisas for ZNF883
      eBioscience FlowRNA Probe Sets
           
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