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ZNF880 Gene

protein-coding   GIFtS: 34
GCID: GC19P052873

Zinc Finger Protein 880

  Search for ZNF880
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger Protein 8801 2
Zinc Finger Protein LOC4007132

External Ids:    HGNC: 372491   Entrez Gene: 4007132   Ensembl: ENSG000002219237   UniProtKB: Q6PDB43   

Export aliases for ZNF880 gene to outside databases

Previous GC identifers: GC19P057568 GC19P049203


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZNF880 Gene:
ZNF880 (zinc finger protein 880) is a protein-coding gene. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF534.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NT_011109.17  NC_018930.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for ZNF880
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF880


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.41   Ensembl cytogenetic band:  19q13.41   HGNC cytogenetic band: 19q13.41

ZNF880 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF880 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P052873:  view genomic region     (about GC identifiers)

Start:
52,873,170 bp from pter      End:
52,889,048 bp from pter
Size:
15,879 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ZN880_HUMAN, Q6PDB4 (See protein sequence)
Recommended Name: Zinc finger protein 880  
Size: 577 amino acids; 66762 Da
Secondary accessions: B4DNA6
Alternative splicing: 2 isoforms:  Q6PDB4-1   Q6PDB4-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ZNF880: NX_Q6PDB4

Explore proteomics data for ZNF880 at MOPED


See ZNF880 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_001138906.1  
ENSEMBL proteins: 
 ENSP00000414470   ENSP00000471067   ENSP00000343625   ENSP00000471324   ENSP00000406318  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
ZNF: Zinc fingers, C2H2-type

4 InterPro protein domains:
 IPR001909 Krueppel-associated_box
 IPR015880 Znf_C2H2-like
 IPR013087 Znf_C2H2/integrase_DNA-bd
 IPR007087 Znf_C2H2

Graphical View of Domain Structure for InterPro Entry Q6PDB4

ProtoNet protein and cluster: Q6PDB4

1 Blocks protein domain: IPB001909 KRAB box

UniProtKB/Swiss-Prot: ZN880_HUMAN, Q6PDB4
Similarity: Contains 14 C2H2-type zinc fingers
Similarity: Contains 1 KRAB domain


ZNF880 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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     Gene Ontology (GO): 3 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003676nucleic acid binding IEA--
GO:0003700sequence-specific DNA binding transcription factor activity IBA--
GO:0046872metal ion binding IEA--
     
ZNF880 for ontologies           About GeneDecksing


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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
nucleus3
mitochondrion1
peroxisome1

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005622intracellular IEA--

ZNF880 for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF880
Interactions:

    Search GeneGlobe Interaction Network for ZNF880

Gene Ontology (GO): 1 biological process term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006355regulation of transcription, DNA-templated IBA--

ZNF880 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for ZNF880 (ZN880)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for ZNF880 gene: 
NM_001145434.1  

Unigene Cluster for ZNF880:

Zinc finger protein 880
Hs.502314  [show with all ESTs]
Unigene Representative Sequence: AK092566
6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000424032 ENST00000600321 ENST00000344085(uc002pzb.4) ENST00000597976
ENST00000422689(uc002pzc.3 uc021uyu.1) ENST00000595099
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Additional mRNA sequence: 

AF086165.1 AF088022.1 AK092566.1 AK297834.1 BC013198.1 BC056265.1 BC058819.1 

10 DOTS entries:

DT.100019117  DT.92062720  DT.100704289  DT.91957344  DT.121450828  DT.70105164  DT.95176488  DT.97826305 
DT.121450887  DT.425441 

Selected AceView cDNA sequences (see all 30):

W15429 BC058819 AI754701 CF134623 AA448488 BU540094 BU184497 CD521389 
BX357926 BM684189 BM719341 AF088022 AI016262 CA437066 W39561 AA446808 
AI004355 CD684894 CD703413 AW024666 BQ447107 AA992166 AI285722 BV178315 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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ZNF880 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
ZNF880 Expression
About this image

ZNF880 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

ZNF880 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.502314
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In Situ
Assay Products:
 

 
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of mammals.

Orthologs for ZNF880 gene from Selected species (see all 3)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
dog
(Canis familiaris)
Mammalia --
Uncharacterized protein
48(a)
many ↔ many
1(104870859-104886591)


ENSEMBL Gene Tree for ZNF880 (if available)
TreeFam Gene Tree for ZNF880 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for ZNF880 gene
ZNF5342  ZNF321P2  ZNF4682  ZNF5782  ZNF7662  ZNF3202  ZNF5252  ZNF8602  
ZNF4152  ZNF6002  ZNF282  ZNF5282  ZNF6112  ZNF6772  ZNF832  ZNF8162  
ZNF6102  ZNF7012  ZNF7652  ZNF4802  ZNF8132  
Selected SIMAP similar genes for ZNF880 using alignment to 3 protein entries:     ZN880_HUMAN (see all proteins) (see all similar genes):
ZNF818P    ZNF721    ZNF616    ZNF78L1    ZNF610    ZNF519
ZNF677    ZNF83    kr-znf3    ZNF480    ZNF611    AURA2
ZNF701    smap-7    ZNF528    ZNF808    ZNF766    ZNF836

ZNF880 for paralogs           About GeneDecksing


1 Pseudogenes.org Pseudogene for ZNF880
PGOHUM00000259419


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for ZNF880 (see all 481)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 19 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1383972531,2
Cuntested152887130(+) AATGCC/TGGAAA 2 A syn10--------
rs576014921,2
C--49202491(+) AAAAA-/AA/AA 
AA
/AAAAA
GGAAA
1 -- us2k11NA 2
rs1457275271,2
C--52871241(+) GAGGTA/CAGGAG 1 -- us2k10--------
rs1883360021,2
--52871308(+) AAAAAA/GATTAG 1 -- us2k10--------
rs1918715001,2
--52871448(+) GCAAGG/TCTCCG 1 -- us2k10--------
rs568282081,2
C--52871471(+) AAAAA-/T/TAAT
        
AATAA
1 -- us2k10--------
rs26579421,2
C--52871477(-) GTATTT/ATTATT 1 -- us2k11Minor allele frequency- A:0.00WA 2
rs176972221,2
C,F,H--52871546(+) TGTTCA/GCCCAT 1 -- us2k121Minor allele frequency- G:0.14NA EA NS 2314
rs1378556981,2
C--52871551(+) ACCCA-/TCTTCTTT 1 -- us2k10--------
rs1866884801,2
--52871673(+) ACTTGA/TTTGAA 1 -- us2k10--------

HapMap Linkage Disequilibrium report for ZNF880 (52873170 - 52889048 bp)

Structural Variations
     Database of Genomic Variants (DGV) Selected variations for ZNF880 (see all 15):    About this table    
Variant IDTypeSubtypePubMed ID
esv2718781CNV Deletion23290073
dgv657e199CNV Deletion23128226
nsv507900CNV Insertion20534489
nsv828615CNV Loss20364138
nsv512590CNV Loss21212237
esv32843CNV Loss17666407
nsv521079CNV Loss19592680
esv2750580CNV Loss17666407
dgv3979n71CNV Loss21882294
dgv3978n71CNV Loss21882294

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for ZNF880 gene integrated from 10 sources:
(articles sorted by number of sources associating them with ZNF880)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
  2. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
  3. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (Nature 2004)
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
  6. Gene expression profile of human bone marrow stromal cells: high-throughput expressed sequence tag sequencing analysis. (PubMed id 11827452)1 Jia L....Francomano C.A. (Genomics 2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 400713 HGNC: 37249 AceView: LOC400713 Ensembl:ENSG00000221923 euGenes: HUgn400713
ECgene: ZNF880 H-InvDB: ZNF880

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for ZNF880 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for ZNF880 gene:
Search GeneIP for patents involving ZNF880

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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 Codon Optimization
 Protein Production and Purification
 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF880
 Browse SwitchGear 3'UTR luciferase reporter plasmids for ZNF880
 Browse SwitchGear Promoter luciferase reporter plasmids for ZNF880
 ThermoFisher Antibodies for ZNF880
 Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat ZNF880
 inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ZNF880
 inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ZNF880
 Search LSBio for Antibodies for ZNF880
Customized transgenic rodents for:
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 Biomarker expression
 Off-target effect monitoring
 Translational medicine
 Tissue-specific gene expresssion
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GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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