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ZNF879 Gene

protein-coding   GIFtS: 36
GCID: GC05P178450

Zinc Finger Protein 879

  Search for ZNF879
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger Protein 8791 2
DKFZp686E24332

External Ids:    HGNC: 372731   Entrez Gene: 3454622   Ensembl: ENSG000002342847   UniProtKB: B4DU553   

Export aliases for ZNF879 gene to outside databases

Previous GC identifers: GC05P178384 GC05P173177


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZNF879 Gene:
ZNF879 (zinc finger protein 879) is a protein-coding gene. An important paralog of this gene is ZNF79.

UniProtKB/Swiss-Prot: ZN879_HUMAN, B4DU55
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000005.10  NT_023133.14  NC_018916.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for ZNF879
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for ZNF879

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF879


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q35.3   Ensembl cytogenetic band:  5q35.3   HGNC cytogenetic band: 5q35.3

ZNF879 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF879 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P178450:  view genomic region     (about GC identifiers)

Start:
178,450,753 bp from pter      End:
178,462,065 bp from pter
Size:
11,313 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ZN879_HUMAN, B4DU55 (See protein sequence)
Recommended Name: Zinc finger protein 879  
Size: 563 amino acids; 64577 Da

Explore the universe of human proteins at neXtProt for ZNF879: NX_B4DU55

Explore proteomics data for ZNF879 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ZNF879 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001129588.1  
    ENSEMBL proteins: 
     ENSP00000414887   ENSP00000430047   ENSP00000428477   ENSP00000431043  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR001909 Krueppel-associated_box
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry B4DU55

    ProtoNet protein and cluster: B4DU55

    UniProtKB/Swiss-Prot: ZN879_HUMAN, B4DU55
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 13 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    ZNF879 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN879_HUMAN, B4DU55
    Function: May be involved in transcriptional regulation

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IBA--
    GO:0046872metal ion binding IEA--
         
    ZNF879 for ontologies           About GeneDecksing


    Animal Models:
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZN879_HUMAN, B4DU55: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--

    ZNF879 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF879
    Interactions:

        Search GeneGlobe Interaction Network for ZNF879

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IBA--

    ZNF879 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZNF879 (ZN879)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ZNF879 gene: 
    NM_001136116.1  

    Unigene Cluster for ZNF879:

    Zinc finger protein 879
    Hs.445740  [show with all ESTs]
    Unigene Representative Sequence: BX648737
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000444149(uc003mjt.4) ENST00000519896 ENST00000522442 ENST00000521285

    miRNA
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    hsa-miR-892b hsa-miR-448 hsa-let-7d hsa-miR-202 hsa-let-7c hsa-miR-3921 hsa-let-7g hsa-let-7a
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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      QuantiFast Probe-based Assays in human, mouse, rat ZNF879

    Additional mRNA sequence: 

    AK300504.1 BX648737.1 

    2 DOTS entries:

    DT.91966419  DT.95121899 

    5 AceView cDNA sequences:

    BM829318 AV750919 CF552564 AV750980 AV748301 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZNF879 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTATTTCACT
    ZNF879 Expression
    About this image

    ZNF879 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZNF879 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.445740
        Custom PCR Arrays for ZNF879
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF879

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for ZNF879 gene from Selected species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfp8791 , 5 zinc figer protein 8795
    zinc finger protein 8791
    79.77(n)1
    80.78(a)1
      11 (30.93 cM)5
    2147791  NM_173387.21  NP_775563.11 
     508320315 


    ENSEMBL Gene Tree for ZNF879 (if available)
    TreeFam Gene Tree for ZNF879 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZNF879 gene
    ZNF792  ZNF5702  ZFP302  ZNF5292  ZNF286B2  ZNF7902  ZNF3832  ZNF1812  
    ZNF2872  ZNF5822  ZNF4712  ZFP822  ZNF286A2  ZNF2502  ZNF354C2  ZNF742  
    ZNF5832  ZNF3912  ZNF5542  ZNF4542  ZFP902  ENSG000001876072  ZFP142  ZNF3312  
    ZNF354A2  ZNF4612  ZNF354B2  ZNF342  ZNF5272  ZNF5652  
    Selected SIMAP similar genes for ZNF879 using alignment to 4 protein entries:     ZN879_HUMAN (see all proteins) (see all similar genes):
    ZNF78L1    ZNF702P    kr-znf3    DKFZp313M0722    FLJ00301    HZF36
    ZNF24    ZNF323    ZNF660    ZNF818P    ZSCAN22    ZSCAN30
    ZSCAN31    zf30    ZNF707    ZNF677    DKFZp666C237    DKFZp762K012

    ZNF879 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for ZNF879
    PGOHUM00000234373 PGOHUM00000258066


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZNF879 (see all 348)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1465072251,2
    --178448806(+) CCAGTC/GATTTC 1 -- us2k10--------
    rs1160563011,2
    F--178448867(+) ACTTGT/CAGCAA 1 -- us2k11Minor allele frequency- C:0.01WA 118
    rs1905841161,2
    --178448925(+) GGTTCC/TTATTT 1 -- us2k10--------
    rs1410154071,2
    --178448957(+) CATCGA/CGGATG 1 -- us2k10--------
    rs1820206591,2
    --178448990(+) CCCTAA/GCTCAT 1 -- us2k10--------
    rs68885391,2
    C,F,A,H--178449010(+) CAAACT/ACCCTA 1 -- us2k114Minor allele frequency- A:0.37NS EA NA WA CSA 785
    rs1862567911,2
    --178449023(+) TTTTAC/TTTACT 1 -- us2k10--------
    rs68885671,2
    C,F,A,H--178449074(+) CTATAT/CCTCTA 1 -- us2k122Minor allele frequency- C:0.35NS EA NA WA CSA 2347
    rs133610771,2
    C,F--178449174(+) TCAGAG/CCACTT 1 -- us2k19Minor allele frequency- C:0.36NA WA CSA EA 368
    rs133595491,2
    C,F,A--178449178(+) AGCACT/ATGTCT 1 -- us2k19Minor allele frequency- A:0.36NA WA CSA EA 368

    HapMap Linkage Disequilibrium report for ZNF879 (178450753 - 178462065 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for ZNF879:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv6389n71CNV Gain21882294
    nsv883221CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ZNF879
    DNA2.0 Custom Variant and Variant Library Synthesis for ZNF879

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZNF879 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with ZNF879)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    2. The DNA sequence and comparative analysis of human chromosome 5. (PubMed id 15372022)2 Schmutz J.... Rubin E.M. (Nature 2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 345462 HGNC: 37273 AceView: LOC345462.1 Ensembl:ENSG00000234284 euGenes: HUgn345462
    ECgene: ZNF879 H-InvDB: ZNF879

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZNF879 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZNF879 gene:
    Search GeneIP for patents involving ZNF879

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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