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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZNF878 Gene

protein-coding   GIFtS: 31
GCID: GC19M012154

Zinc Finger Protein 878

  Search for ZNF878
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Zinc Finger Protein 8781 2

External Ids:    HGNC: 372461   Entrez Gene: 7297472   Ensembl: ENSG000002574467   UniProtKB: C9JN713   

Export aliases for ZNF878 gene to outside databases

Previous GC identifers: GC19M012017 GC19M011728


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ZNF878 Gene: 
ZNF878 (zinc finger protein 878) is a protein-coding gene. GO annotations related to this gene include zinc ion binding and nucleic acid binding. An important paralog of this gene is ZNF669.

UniProtKB/Swiss-Prot: ZN878_HUMAN, C9JN71
Function: May be involved in transcriptional regulation (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.2  NT_011295.11  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for ZNF878
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for ZNF878

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF878


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.2   Ensembl cytogenetic band:  19p13.2   HGNC cytogenetic band: 19p13.2

ZNF878 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF878 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M012154:  view genomic region     (about GC identifiers)

Start:
12,154,620 bp from pter      End:
12,167,127 bp from pter
Size:
12,508 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZN878_HUMAN, C9JN71 (See protein sequence)
Recommended Name: Zinc finger protein 878  
Size: 531 amino acids; 61540 Da
Subcellular location: Nucleus (Potential)

Explore the universe of human proteins at neXtProt for ZNF878: NX_C9JN71

Explore proteomics data for ZNF878 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_C9JN71

  • ZNF878 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ZNF878 Protein Expression
    REFSEQ proteins: NP_001073873.2  
    ENSEMBL proteins: 
     ENSP00000447931   ENSP00000472036  

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    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--

    ZNF878 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR001909 Krueppel-associated_box
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry C9JN71

    ProtoNet protein and cluster: C9JN71

    UniProtKB/Swiss-Prot: ZN878_HUMAN, C9JN71
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 15 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    ZNF878 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN878_HUMAN, C9JN71
    Function: May be involved in transcriptional regulation (By similarity)

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding IEA--
    GO:0008270zinc ion binding ----
    GO:0046872metal ion binding IEA--
         
    ZNF878 for ontologies           About GeneDecksing


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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF878

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--

    ZNF878 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for ZNF878 (ZN878)

    Search CenterWatch for drugs/clinical trials and news about ZNF878 / ZN878

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    About This Section

    REFSEQ mRNAs for ZNF878 gene: 
    NM_001080404.2  

    Unigene Cluster for ZNF878:

    Zinc finger protein 878
    Hs.704229  [show with all ESTs]
    Unigene Representative Sequence: NM_001080404
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000547628(uc021upl.1 uc002mta.1) ENST00000602107
    miRNA
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    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZNF878 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAAGGACTCA
    ZNF878 Expression
    About this image


    See ZNF878 Protein Expression from SPIRE MOPED and PaxDB
    SOURCE GeneReport for Unigene cluster: Hs.704229
        SABiosciences Custom PCR Arrays for ZNF878
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of human and mouse.

    Orthologs for ZNF878 gene from 1/5 species (see all 5)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfp9581 , 5 zinc finger protein 9581, 5 68.09(n)1
    58.03(a)1
      8 (2.07 cM)5
    2339871  NM_145591.41  NP_663566.11 
     46258405 


    ENSEMBL Gene Tree for ZNF878 (if available)
    TreeFam Gene Tree for ZNF878 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZNF878 gene
    ZNF6692  ZNF5642  ZNF4902  ZNF4412  ZNF625-ZNF202  ENSG000002671792  ZNF142  ENSG000002697552  
    ENSG000001968262  ZNF7002  ZNF692  ZNF4402  ZNF4432  ZNF442  ZNF4392  ZNF8232  
    ENSG000001884742  ZNF4912  ZNF5552  ENSG000002688702  ZNF7092  ZNF6252  ZNF7992  ZNF202  
    ZNF7882  ZNF1012  ZNF7912  ZNF4422  ZNF4332  ZNF572  ZNF5632  ZNF6272  
    ENSG000002573552  ZNF1362  ZNF5562  ZNF6702  ZNF7632  ZNF1242  ENSG000002687442  ZNF6992  
    ZNF8442  ZNF772  
    18/528 SIMAP similar genes for ZNF878 using alignment to 2 protein entries:     ZN878_HUMAN (see all proteins) (see all similar genes):
    ZNF669    FIK    ZNF274    ZNF78L1    ZNF761    ZNF625
    HZF16    ZNF826P    ZNF433    MGC12518    ZNF791    DKFZp313M0722
    DKFZp666C237    KRBOX4    ZNF20    ZNF323    ZNF664    ZNF528

    ZNF878 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/248 SNPs in ZNF878 are shown (see all 248)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs81047591,2
    C,F--12154120(+) tttatT/Gtattt 1 -- ds50012Minor allele frequency- G:0.00NA 4
    rs1468455561,2
    --12154188(+) ATCTCA/GGCTTA 1 -- ds50010--------
    rs1406844301,2
    --12154319(+) CTCTAC/TGTCGA 1 -- ds50010--------
    rs1128178371,2
    C,F--12154337(+) GGTCTC/TGAACT 1 -- ds50012Minor allele frequency- T:0.50WA CSA 4
    rs783983451,2
    C--12154448(+) ATAACG/ATCTCA 1 -- ds50014Minor allele frequency- A:0.14NA CSA WA 242
    rs1842807891,2
    --12154482(+) ACCTCG/TTCAGC 1 -- ds50010--------
    rs1454891801,2
    C--12154495(+) AAGCAA/GTCCTC 1 -- ds50010--------
    rs1488570001,2
    --12154521(+) AAAATA/GCTGAG 1 -- ds50010--------
    rs1166939431,2
    C,F--12154535(+) ACAGGT/AGTCTC 1 -- ds50011Minor allele frequency- A:0.02WA 118
    rs1434287421,2
    --12154557(+) CTTCCA/GTGCAT 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for ZNF878 (12154620 - 12167127 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for ZNF878:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv911069CNV Loss21882294
    nsv525966CNV Gain19592680
    nsv911068CNV Gain21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZNF878 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ZNF878)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    2. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    3. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 729747 HGNC: 37246 Ensembl:ENSG00000257446 euGenes: HUgn729747 ECgene: ZNF878
    H-InvDB: ZNF878

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZNF878 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZNF878 gene:
    Search GeneIP for patents involving ZNF878

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
    transforming growth factor, beta 1
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