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Aliases for ZNF878 Gene

Aliases for ZNF878 Gene

  • Zinc Finger Protein 878 2 3 5

External Ids for ZNF878 Gene

Previous GeneCards Identifiers for ZNF878 Gene

  • GC19M012017
  • GC19M012154
  • GC19M011728

Summaries for ZNF878 Gene

GeneCards Summary for ZNF878 Gene

ZNF878 (Zinc Finger Protein 878) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF433.

UniProtKB/Swiss-Prot for ZNF878 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF878 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF878 Gene

Genomics for ZNF878 Gene

Regulatory Elements for ZNF878 Gene

Enhancers for ZNF878 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19H012983 2 FANTOM5 Ensembl ENCODE dbSUPER 40.2 -931.8 -931836 3 HDGF PKNOX1 FOXA2 MLX SIN3A ARID4B DMAP1 ZNF2 ZNF766 ZNF143 ZNF136 ZNF442 CCDC130 ZNF564 ZNF625 ZNF844 ZNF799 WDR83OS MRI1 ZNF44
GH19H012781 1.9 FANTOM5 ENCODE dbSUPER 41.8 -736.3 -736331 15 MLX FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC MEF2D ZNF610 ZNF136 CCDC130 ZNF791 ZNF44 ZNF442 ZNF564 TRMT1 ZNF844 TRIR ZNF700
GH19H011531 1.5 FANTOM5 Ensembl ENCODE 32.8 +520.5 520529 1 PKNOX1 ATF1 ZNF493 ZFP64 FOS ZNF202 ZC3H11A REST ZNF623 ZNF518A ZNF627 ZNF136 ILF3 ZNF442 ZNF844 ZNF625 ZNF44 KRI1 ZNF20 ZNF763
GH19H011150 1.6 Ensembl ENCODE dbSUPER 21.9 +899.1 899145 6 HDGF PKNOX1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 KRI1 ILF3 TIMM29 ZNF20 ZNF700 ZNF627 ZNF433 ZNF878 ZNF763 ZNF440
GH19H012293 1.4 FANTOM5 ENCODE 22.9 -241.6 -241550 2 PKNOX1 MLX ARID4B SIN3A YY1 ZNF766 CBX5 ZNF143 FOS SP3 ZNF44 ZNF136 ZNF20 ZNF763 ZNF700 ZNF878 TRMT1 ZNF490 TRIR ZNF564
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF878 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF878 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000107241 466 1799 HDGF PKNOX1 ARID4B DMAP1 ETS1 SLC30A9 ZNF207 RUNX3 SP5 MXD4

Genomic Location for ZNF878 Gene

Chromosome:
19
Start:
12,043,648 bp from pter
End:
12,052,967 bp from pter
Size:
9,320 bases
Orientation:
Minus strand

Genomic View for ZNF878 Gene

Genes around ZNF878 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF878 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF878 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF878 Gene

Proteins for ZNF878 Gene

  • Protein details for ZNF878 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    C9JN71-ZN878_HUMAN
    Recommended name:
    Zinc finger protein 878
    Protein Accession:
    C9JN71

    Protein attributes for ZNF878 Gene

    Size:
    531 amino acids
    Molecular mass:
    61540 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF878 Gene

Post-translational modifications for ZNF878 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF878 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF878 Gene

Domains & Families for ZNF878 Gene

Gene Families for ZNF878 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF878 Gene

Suggested Antigen Peptide Sequences for ZNF878 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

C9JN71

UniProtKB/Swiss-Prot:

ZN878_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF878: view

Function for ZNF878 Gene

Molecular function for ZNF878 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF878 Gene

Gene Ontology (GO) - Molecular Function for ZNF878 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF878: view

Phenotypes for ZNF878 Gene

genes like me logo Genes that share phenotypes with ZNF878: view

Animal Model Products

CRISPR Products

miRNA for ZNF878 Gene

miRTarBase miRNAs that target ZNF878

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ZNF878
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF878 Gene

Localization for ZNF878 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF878 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF878 gene
Compartment Confidence
nucleus 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF878 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF878: view

Pathways & Interactions for ZNF878 Gene

SuperPathways for ZNF878 Gene

No Data Available

Interacting Proteins for ZNF878 Gene

Gene Ontology (GO) - Biological Process for ZNF878 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF878: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF878 Gene

Drugs & Compounds for ZNF878 Gene

No Compound Related Data Available

Transcripts for ZNF878 Gene

mRNA/cDNA for ZNF878 Gene

(3) REFSEQ mRNAs :
(0) Additional mRNA sequences :
-
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF878 Gene

Zinc finger protein 878:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ZNF878
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF878 Gene

No ASD Table

Relevant External Links for ZNF878 Gene

GeneLoc Exon Structure for
ZNF878
ECgene alternative splicing isoforms for
ZNF878

Expression for ZNF878 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF878 Gene

Protein differential expression in normal tissues from HIPED for ZNF878 Gene

This gene is overexpressed in Bone marrow stromal cell (61.6) and Bone marrow mesenchymal stem cell (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZNF878 Gene



Protein tissue co-expression partners for ZNF878 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF878 Gene:

ZNF878

SOURCE GeneReport for Unigene cluster for ZNF878 Gene:

Hs.704229
genes like me logo Genes that share expression patterns with ZNF878: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF878 Gene

Orthologs for ZNF878 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF878 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF878 33 34
  • 99.4 (n)
mouse
(Mus musculus)
Mammalia Zfp617 33 16
  • 68.25 (n)
Gm14408 34
  • 50 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia LOC102548917 33
  • 66.98 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 53 (a)
ManyToMany
-- 34
  • 46 (a)
ManyToMany
-- 34
  • 46 (a)
ManyToMany
-- 34
  • 45 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 45 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 40 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii CT573234.2 34
  • 41 (a)
ManyToMany
CR388132.2 34
  • 40 (a)
ManyToMany
Species where no ortholog for ZNF878 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF878 Gene

ENSEMBL:
Gene Tree for ZNF878 (if available)
TreeFam:
Gene Tree for ZNF878 (if available)

Paralogs for ZNF878 Gene

(530) SIMAP similar genes for ZNF878 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ZNF878: view

Variants for ZNF878 Gene

Sequence variations from dbSNP and Humsavar for ZNF878 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000060186 -- 12,047,996(+) ATGAC(A/G)TTGTC intron-variant, upstream-variant-2KB
rs1000189957 -- 12,047,779(+) ATGAT(A/G)AAACC intron-variant, upstream-variant-2KB
rs1000196831 -- 12,051,498(+) GGAGT(A/G)CAGTG intron-variant
rs1000270526 -- 12,051,832(+) AACCC(A/G)GGAGG intron-variant
rs1000529517 -- 12,050,142(+) ATCGA(C/T)TGAAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF878 Gene

Variant ID Type Subtype PubMed ID
esv3643691 CNV loss 21293372
nsv525966 CNV gain 19592680
nsv578619 CNV loss 21841781
nsv963005 CNV duplication 23825009

Variation tolerance for ZNF878 Gene

Residual Variation Intolerance Score: 92% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.97; 68.16% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF878 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF878

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF878 Gene

Disorders for ZNF878 Gene

Relevant External Links for ZNF878

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF878

No disorders were found for ZNF878 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF878 Gene

Publications for ZNF878 Gene

  1. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 60
  2. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 4 60

Products for ZNF878 Gene

Sources for ZNF878 Gene

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