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ZNF865 Gene

protein-coding   GIFtS: 30
GCID: GC19P056125

Zinc Finger Protein 865

  Search for ZNF865
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger Protein 8651 2

External Ids:    HGNC: 387051   Entrez Gene: 1005072902   Ensembl: ENSG000002612217   UniProtKB: P0CJ783   

Export aliases for ZNF865 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZNF865 Gene:
ZNF865 (zinc finger protein 865) is a protein-coding gene.

UniProtKB/Swiss-Prot: ZN865_HUMAN, P0CJ78
Function: May be involved in transcriptional regulation (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Search for regulatory transcription factor binding sites for ZNF865
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for ZNF865

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF865


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.42   Ensembl cytogenetic band:  19q13.42   HGNC cytogenetic band: 19q13.42

ZNF865 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF865 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P056125:  view genomic region     (about GC identifiers)

Start:
56,116,771 bp from pter      End:
56,129,911 bp from pter
Size:
13,141 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ZN865_HUMAN, P0CJ78 (See protein sequence)
Recommended Name: Zinc finger protein 865  
Size: 1059 amino acids; 111077 Da

Explore the universe of human proteins at neXtProt for ZNF865: NX_P0CJ78

Explore proteomics data for ZNF865 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ZNF865 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001182534.1  
    ENSEMBL proteins: 
     ENSP00000457715  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    3 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry P0CJ78

    ProtoNet protein and cluster: P0CJ78

    UniProtKB/Swiss-Prot: ZN865_HUMAN, P0CJ78
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 20 C2H2-type zinc fingers


    ZNF865 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN865_HUMAN, P0CJ78
    Function: May be involved in transcriptional regulation (By similarity)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0046872metal ion binding IEA--
         
    ZNF865 for ontologies           About GeneDecksing


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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZN865_HUMAN, P0CJ78: Nucleus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    mitochondrion1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    ZNF865 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Interactions:

        Search GeneGlobe Interaction Network for ZNF865

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--

    ZNF865 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Tocris compounds for ZNF865 (ZN865)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ZNF865 gene: 
    NM_001195605.1  

    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000568956
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    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    See probesets specificity/sensitivity at GeneAnnot
    CGAP TAG: --

    ZNF865 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZNF865 Protein Expression
        Custom PCR Arrays for ZNF865
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ZNF865 gene from Selected species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfp8651 , 5 zinc finger protein 8651, 5 83.6(n)1
    88.75(a)1
      7 (2.90 cM)5
    3197481  NM_001033383.21  NP_001028555.11 
     50203765 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia znf8651 zinc finger protein 865 64.69(n)
    72.46(a)
      100145461  NM_001126914.1  NP_001120386.1 
    zebrafish
    (Danio rerio)
    Actinopterygii znf8656
    zinc finger protein 865
    17(a)
    1 ↔ 1
    19(10823706-10836801) ENSDARG00000036698


    ENSEMBL Gene Tree for ZNF865 (if available)
    TreeFam Gene Tree for ZNF865 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZNF865 gene
    Selected SIMAP similar genes for ZNF865 using alignment to 1 protein entry:     ZN865_HUMAN(see all similar genes):
    ZNF55    ZNF    ZNF78L1    ZFP41    DKFZp434J0650    ZFS-5
    DKFZp666C237    ZFS-6    DKFZp313M0722    GLI4    ZNF323    ZNF568
    ZNF697    ZNF707    kr-znf3    DKFZp686H10254    ZIK1    ZNF22

    ZNF865 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZNF865 (see all 85)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs744941781,2
    F--56122976(+) ATGGCG/ATTTGG 1 -- us2k11Minor allele frequency- A:0.50NA 2
    rs1474165511,2
    C--56123117(+) CCCCCA/GTCGGG 1 -- us2k10--------
    rs1855687161,2
    --56123119(+) CCCATC/TGGGTA 1 -- us2k10--------
    rs1181729621,2
    C,F--56123120(+) CCATCG/TGGTAG 1 -- us2k11Minor allele frequency- T:0.03NA 120
    rs1396534851,2
    C--56123154(+) AGACCA/TCATGG 1 -- us2k10--------
    rs1451922891,2
    --56123161(+) ATGGGC/TCCTTC 1 -- us2k10--------
    rs1404318791,2
    C--56123199(+) AGGTG-/CCTTCC 1 -- us2k10--------
    rs1476417911,2
    C--56123244(+) AGTTAC/TGGGTG 1 -- us2k10--------
    rs1140083921,2
    C--56123245(+) GTTACA/GGGTGC 1 -- us2k10--------
    rs1496709351,2
    --56123311(+) AAGTCA/GTGTAA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ZNF865 (56116771 - 56129911 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for ZNF865:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2658464CNV Deletion23128226
    nsv912499CNV Loss21882294
    nsv828643CNV Loss20364138
    nsv912502CNV Loss21882294
    dgv4025n71CNV Loss21882294
    nsv912473CNV Loss21882294
    nsv912500CNV Loss21882294
    nsv912501CNV Loss21882294
    nsv912486CNV Loss21882294
    dgv4026n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZNF865 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with ZNF865)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (Nature 2004)
    2. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    3. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 100507290 HGNC: 38705 Ensembl:ENSG00000261221 euGenes: HUgn100507290 ECgene: ZNF865
    H-InvDB: ZNF865

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZNF865 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZNF865 gene:
    Search GeneIP for patents involving ZNF865

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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     Browse SwitchGear 3'UTR luciferase reporter plasmids for ZNF865
     Browse SwitchGear Promoter luciferase reporter plasmids for ZNF865
     Search ThermoFisher Antibodies for ZNF865
     Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat ZNF865
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ZNF865
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ZNF865
     LSBio Antibodies in human, mouse, rat for ZNF865
    Customized transgenic rodents for:
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