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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZNF862 Gene

protein-coding   GIFtS: 42
GCID: GC07P149535

Zinc Finger Protein 862

  Search for ZNF862
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Zinc Finger Protein 8621 2
KIAA05433

External Ids:    HGNC: 345191   Entrez Gene: 6436412   Ensembl: ENSG000001064797   UniProtKB: O602903   

Export aliases for ZNF862 gene to outside databases

Previous GC identifers: GC07P149166 GC07P143610


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ZNF862 Gene: 
ZNF862 (zinc finger protein 862) is a protein-coding gene. GO annotations related to this gene include protein dimerization activity and molecular_function. An important paralog of this gene is KIAA1586.

UniProtKB/Swiss-Prot: ZN862_HUMAN, O60290
Function: May be involved in transcriptional regulation (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NT_007914.15  NC_018918.2  NT_079596.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZNF862 gene promoter:
         NF-1/L   NF-1   Lmo2   AP-2gamma   E47   HEN1   AP-2beta   Hand1   AP-2alpha   AP-2alphaA   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for ZNF862

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF862


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q36.1   Ensembl cytogenetic band:  7q36.1   HGNC cytogenetic band: 7q36.1

ZNF862 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF862 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P149535:  view genomic region     (about GC identifiers)

Start:
149,535,456 bp from pter      End:
149,564,568 bp from pter
Size:
29,113 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 148,873,528-148,902,587     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZN862_HUMAN, O60290 (See protein sequence)
Recommended Name: Zinc finger protein 862  
Size: 1169 amino acids; 131654 Da
Subcellular location: Nucleus (Potential)
Secondary accessions: A0AUL8
Alternative splicing: 2 isoforms:  O60290-1   O60290-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ZNF862: NX_O60290

Explore proteomics data for ZNF862 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O60290

  • ZNF862 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ZNF862 Protein Expression
    REFSEQ proteins: NP_001092690.1  
    ENSEMBL proteins: 
     ENSP00000223210   ENSP00000417450  

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    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--

    ZNF862 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZNF: Zinc fingers, C2H2-type

    5 InterPro protein domains:
     IPR006580 Znf_TTF
     IPR001909 Krueppel-associated_box
     IPR008906 HATC
     IPR026613 KRAB_dom_C2H2_Znf_fam
     IPR012337 RNaseH-like_dom

    Graphical View of Domain Structure for InterPro Entry O60290

    ProtoNet protein and cluster: O60290

    1 Blocks protein domain: IPB001909 KRAB box

    UniProtKB/Swiss-Prot: ZN862_HUMAN, O60290
    Similarity: Contains 2 KRAB domains
    Similarity: Contains 2 TTF-type zinc fingers


    ZNF862 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN862_HUMAN, O60290
    Function: May be involved in transcriptional regulation (By similarity)

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0003676nucleic acid binding IEA--
    GO:0046872metal ion binding IEA--
    GO:0046983protein dimerization activity IEA--
         
    ZNF862 for ontologies           About GeneDecksing


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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF862

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    5/7 Interacting proteins for ZNF862 (O602902, 3 ENSP000002232104) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ATN1P542592, 3, ENSP000003490764MINT-2870666 I2D: score=2 STRING: ENSP00000349076
    TTC28Q96AY43, ENSP000003810034I2D: score=1 STRING: ENSP00000381003
    ATXN7L1Q9ULK23I2D: score=2 
    AMBRA1Q9C0C73I2D: score=1 
    MAP1LC3BQ9GZQ83I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--
    GO:0008150biological_process ND--

    ZNF862 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for ZNF862 (ZN862)

    Search CenterWatch for drugs/clinical trials and news about ZNF862 / ZN862

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZNF862 gene: 
    NM_001099220.1  

    Unigene Cluster for ZNF862:

    Zinc finger protein 862
    Hs.731923  [show with all ESTs]
    Unigene Representative Sequence: NM_001099220
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000223210(uc010lpn.3) ENST00000489820 ENST00000460379 ENST00000488265
    ENST00000466435 ENST00000478024
    miRNA
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    8/39 QIAGEN miScript miRNA Assays for microRNAs that regulate ZNF862 (see all 39):
    hsa-miR-302d hsa-miR-520e hsa-miR-520f hsa-miR-1224-3p hsa-miR-106a hsa-miR-3916 hsa-miR-890 hsa-miR-372
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF862

    Additional mRNA sequence: 

    AK054924.1 AK128787.1 BC041427.1 BC045757.1 BC092506.1 BC113087.1 

    11 DOTS entries:

    DT.99950625  DT.211597  DT.411971  DT.100813852  DT.75105802  DT.100813851  DT.91838669  DT.121117194 
    DT.121117228  DT.100742684  DT.95157722 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZNF862 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTGATTCCT
    ZNF862 Expression
    About this image


    See ZNF862 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZNF862

    SOURCE GeneReport for Unigene cluster: Hs.731923
        SABiosciences Custom PCR Arrays for ZNF862
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for ZNF862 gene from 2/7 species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfp8625 zinc finger protein 862   --   6 (23.48 cM) 48504339 
    lizard
    (Anolis carolinensis)
    Reptilia ZNF8626
    Uncharacterized protein
    24(a)
    1 ↔ 1
    GL343241.1(1687975-1689336)


    ENSEMBL Gene Tree for ZNF862 (if available)
    TreeFam Gene Tree for ZNF862 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZNF862 gene
    KIAA15862  
    1 SIMAP similar gene for ZNF862 using alignment to 2 protein entries:     ZN862_HUMAN (see all proteins):
    ZNF250

    ZNF862 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for ZNF862
    PGOHUM00000242659 PGOHUM00000236284


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/759 SNPs in ZNF862 are shown (see all 759)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs715316521,2
    C--149533584(+) ATCTC-/A/AAA 
            
    AAAAA
    2 -- us2k1 cds11NA 2
    rs125306071,2
    C,F,A,H--149533632(+) GCCCTC/TGATAC 1 -- us2k114Minor allele frequency- T:0.26NS EA NA WA CSA 754
    rs1475491351,2
    --149533647(+) TTCCTA/GGACCC 1 -- us2k10--------
    rs1156838031,2
    C,F--149533744(+) TGACTC/GATATC 1 -- us2k11Minor allele frequency- G:0.09WA 118
    rs1810714741,2
    --149533761(+) CTACTA/GCTTTG 1 -- us2k10--------
    rs743742751,2
    C,F--149533783(+) CCCCCT/AAGATA 1 -- us2k11Minor allele frequency- A:0.03EA 120
    rs1142597331,2
    F--149533812(+) AAAGAT/CGGAAA 1 -- us2k11Minor allele frequency- C:0.01WA 118
    rs69582351,2
    C,F,A,H--149533883(+) accccT/CaAAAG 1 -- us2k110Minor allele frequency- C:0.23NS EA NA WA CSA 736
    rs1398230811,2
    --149533957(+) TAGTCA/GAGGTG 1 -- us2k10--------
    rs1156584561,2
    C,F--149534073(+) TCCTCG/AAACGG 1 -- us2k11Minor allele frequency- A:0.05WA 118

    HapMap Linkage Disequilibrium report for ZNF862 (149535456 - 149564568 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/22 variations for ZNF862 (see all 22):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2735336CNV Deletion23290073
    esv2735335CNV Deletion23290073
    esv1920108CNV Deletion18987734
    esv2735337CNV Deletion23290073
    nsv521861CNV Loss19592680
    nsv365614CNV Loss16902084
    nsv519323CNV Loss19592680
    dgv7530n71CNV Loss21882294
    nsv889409CNV Loss21882294
    nsv517242CNV Loss19592680

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZNF862 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ZNF862)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9628581)1, 2 Nagase T....Ohara O. (1998)
    2. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
    5. The DNA sequence of human chromosome 7. (PubMed id 12853948)2 Hillier L.W.... Wilson R.K. (2003)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 643641 HGNC: 34519 Ensembl:ENSG00000106479 euGenes: HUgn643641 ECgene: ZNF862
    H-InvDB: ZNF862

    (According to HUGE)
    About This Section
    HUGE: KIAA0543

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZNF862 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZNF862 gene:
    Search GeneIP for patents involving ZNF862

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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