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Aliases for ZNF862 Gene

Aliases for ZNF862 Gene

  • Zinc Finger Protein 862 2 3 5
  • KIAA0543 4

External Ids for ZNF862 Gene

Previous GeneCards Identifiers for ZNF862 Gene

  • GC07P149166
  • GC07P149535
  • GC07P143610

Summaries for ZNF862 Gene

GeneCards Summary for ZNF862 Gene

ZNF862 (Zinc Finger Protein 862) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and protein dimerization activity. An important paralog of this gene is KIAA1586.

UniProtKB/Swiss-Prot for ZNF862 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF862 Gene

Genomics for ZNF862 Gene

Regulatory Elements for ZNF862 Gene

Enhancers for ZNF862 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around ZNF862 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF862 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for ZNF862 Gene

Chromosome:
7
Start:
149,838,367 bp from pter
End:
149,867,479 bp from pter
Size:
29,113 bases
Orientation:
Plus strand

Genomic View for ZNF862 Gene

Genes around ZNF862 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF862 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF862 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF862 Gene

Proteins for ZNF862 Gene

  • Protein details for ZNF862 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60290-ZN862_HUMAN
    Recommended name:
    Zinc finger protein 862
    Protein Accession:
    O60290
    Secondary Accessions:
    • A0AUL8

    Protein attributes for ZNF862 Gene

    Size:
    1169 amino acids
    Molecular mass:
    131654 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF862 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF862 Gene

Post-translational modifications for ZNF862 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF862 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF862 Gene

Domains & Families for ZNF862 Gene

Gene Families for ZNF862 Gene

Protein Domains for ZNF862 Gene

Suggested Antigen Peptide Sequences for ZNF862 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O60290

UniProtKB/Swiss-Prot:

ZN862_HUMAN :
  • Contains 2 KRAB domains.
  • Contains 2 TTF-type zinc fingers.
Domain:
  • Contains 2 KRAB domains.
Similarity:
  • Contains 2 TTF-type zinc fingers.
genes like me logo Genes that share domains with ZNF862: view

Function for ZNF862 Gene

Molecular function for ZNF862 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF862 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0003676 nucleic acid binding IEA --
GO:0046872 metal ion binding IEA --
GO:0046983 protein dimerization activity IEA --
genes like me logo Genes that share ontologies with ZNF862: view

Phenotypes for ZNF862 Gene

genes like me logo Genes that share phenotypes with ZNF862: view

Animal Model Products

CRISPR Products

miRNA for ZNF862 Gene

miRTarBase miRNAs that target ZNF862

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF862 Gene

Localization for ZNF862 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF862 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF862 Gene COMPARTMENTS Subcellular localization image for ZNF862 gene
Compartment Confidence
nucleus 4
mitochondrion 3
cytosol 2
endoplasmic reticulum 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for ZNF862 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF862: view

Pathways & Interactions for ZNF862 Gene

SuperPathways for ZNF862 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF862 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with ZNF862: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF862 Gene

Drugs & Compounds for ZNF862 Gene

No Compound Related Data Available

Transcripts for ZNF862 Gene

mRNA/cDNA for ZNF862 Gene

(7) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF862 Gene

Zinc finger protein 862:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF862 Gene

No ASD Table

Relevant External Links for ZNF862 Gene

GeneLoc Exon Structure for
ZNF862
ECgene alternative splicing isoforms for
ZNF862

Expression for ZNF862 Gene

mRNA expression in normal human tissues for ZNF862 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF862 Gene:

ZNF862

SOURCE GeneReport for Unigene cluster for ZNF862 Gene:

Hs.731923
genes like me logo Genes that share expression patterns with ZNF862: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for ZNF862 Gene

Orthologs for ZNF862 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF862 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ZNF862 34
  • 83.55 (n)
  • 81.1 (a)
ZNF862 35
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF862 34
  • 85.14 (n)
  • 85.2 (a)
ZNF862 35
  • 85 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ZNF862 34
  • 99.49 (n)
  • 99.57 (a)
ZNF862 35
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zfp862 34
  • 78.62 (n)
  • 74.38 (a)
oppossum
(Monodelphis domestica)
Mammalia ZNF862 35
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZNF862 35
  • 71 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZNF862 35
  • 25 (a)
OneToOne
Species where no ortholog for ZNF862 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF862 Gene

ENSEMBL:
Gene Tree for ZNF862 (if available)
TreeFam:
Gene Tree for ZNF862 (if available)

Paralogs for ZNF862 Gene

Paralogs for ZNF862 Gene

(1) SIMAP similar genes for ZNF862 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for ZNF862 Gene

genes like me logo Genes that share paralogs with ZNF862: view

Variants for ZNF862 Gene

Sequence variations from dbSNP and Humsavar for ZNF862 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs3735328 - 149,848,026(+) ACTAA(C/T)AGAAG nc-transcript-variant, reference, missense
rs2240361 -- 149,861,320(+) CTGCT(C/G)CCTGT nc-transcript-variant, reference, synonymous-codon
rs2240363 -- 149,863,696(+) CACCG(A/C/G)TGCCT intron-variant
rs2373465 -- 149,866,045(-) GTACC(A/G)GGGAG nc-transcript-variant, utr-variant-3-prime
rs7799865 -- 149,843,725(+) CCTCA(C/T)GTAAA intron-variant, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for ZNF862 Gene

Variant ID Type Subtype PubMed ID
dgv11717n54 CNV gain 21841781
dgv6751n100 CNV gain 25217958
dgv6752n100 CNV gain 25217958
dgv845n27 CNV gain 19166990
esv1920108 CNV deletion 18987734
esv2735335 CNV deletion 23290073
esv2735336 CNV deletion 23290073
esv2735337 CNV deletion 23290073
esv2759571 CNV gain 17122850
esv3576480 CNV gain 25503493
esv3615438 CNV gain 21293372
esv3891234 CNV gain 25118596
nsv1029484 CNV gain 25217958
nsv1033095 CNV gain 25217958
nsv1149876 CNV deletion 26484159
nsv1161666 CNV duplication 26073780
nsv365614 CNV deletion 16902084
nsv469576 CNV loss 16826518
nsv517242 CNV loss 19592680
nsv519323 CNV loss 19592680
nsv521861 CNV loss 19592680
nsv608987 CNV loss 21841781
nsv8229 CNV gain+loss 18304495
nsv831184 CNV gain 17160897
nsv831185 CNV gain 17160897

Variation tolerance for ZNF862 Gene

Residual Variation Intolerance Score: 86.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.13; 80.65% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF862 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF862

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF862 Gene

Disorders for ZNF862 Gene

Relevant External Links for ZNF862

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF862

No disorders were found for ZNF862 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF862 Gene

Publications for ZNF862 Gene

  1. Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9628581) Nagase T. … Ohara O. (DNA Res. 1998) 3 4 65
  2. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 65
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 65
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 65
  5. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier L.W. … Wilson R.K. (Nature 2003) 4 65

Products for ZNF862 Gene

Sources for ZNF862 Gene

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