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ZNF853 Gene

protein-coding   GIFtS: 35
GCID: GC07P006661

Zinc Finger Protein 853

  Search for ZNF853
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger Protein 8531 2

External Ids:    HGNC: 217671   Entrez Gene: 547532   Ensembl: ENSG000002366097   UniProtKB: P0CG233   

Export aliases for ZNF853 gene to outside databases

Previous GC identifers: GC07P006649 GC07P006621 GC07P006656 GC07P006657


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZNF853 Gene:
ZNF853 (zinc finger protein 853) is a protein-coding gene. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF787.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000007.14  NC_018918.2  NT_007819.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZNF853 gene promoter:
         NF-1   AML1a   Tal-1   Pax-5   Lmo2   Zic3   E47   c-Ets-1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for ZNF853

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF853


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p22.1   Ensembl cytogenetic band:  7p22.1   HGNC cytogenetic band: 7p22.1

ZNF853 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF853 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P006661:  view genomic region     (about GC identifiers)

Start:
6,655,248 bp from pter      End:
6,663,921 bp from pter
Size:
8,674 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 6,702,580-6,710,967     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ZN853_HUMAN, P0CG23 (See protein sequence)
Recommended Name: Zinc finger protein 853  
Size: 659 amino acids; 74878 Da

Explore the universe of human proteins at neXtProt for ZNF853: NX_P0CG23

Explore proteomics data for ZNF853 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ZNF853 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_060030.1  
    ENSEMBL proteins: 
     ENSP00000455585  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    3 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry P0CG23

    ProtoNet protein and cluster: P0CG23

    UniProtKB/Swiss-Prot: ZN853_HUMAN, P0CG23
    Similarity: Contains 5 C2H2-type zinc fingers


    ZNF853 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding IEA--
    GO:0046872metal ion binding IEA--
         
    ZNF853 for ontologies           About GeneDecksing


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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF853
    Interactions:

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    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZNF853 (ZN853)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ZNF853 gene: 
    NM_017560.1  

    Unigene Cluster for ZNF853:

    Zinc finger protein 853
    Hs.592170  [show with all ESTs]
    Unigene Representative Sequence: NM_017560
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000457543(uc011jwz.2)
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    Additional mRNA sequence: 

    AL133055.1 AL390175.1 

    5 DOTS entries:

    DT.443530  DT.40223642  DT.92005216  DT.100800875  DT.120808118 

    Selected AceView cDNA sequences (see all 54):

    AI095022 CD674236 BQ940467 BM930152 BG059923 AW874500 BF527438 AW026444 
    BM141884 BG056605 CK906091 BX433149 AL048863 AW264366 CA418704 AW475080 
    BF437357 BM142191 AW615734 BF204282 BM127175 AI627908 AI138531 AL390175 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZNF853 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTTGGTAAG
    ZNF853 Expression
    About this image

    ZNF853 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZNF853 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.592170
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ZNF853 gene from Selected species (see all 5)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfp8535 zinc finger protein 853   --   5 (82.06 cM) 143287755 
    zebrafish
    (Danio rerio)
    Actinopterygii ZNF7876
    zinc finger protein 787
    31(a)
    1 → many
    17(50980703-50986718) ENSDARG00000097191
    fruit fly
    (Drosophila melanogaster)
    Insecta phol6
    pho6
    pleiohomeotic
    7(a)
    7(a)
    many ↔ many
    many ↔ many
    3L(9446148-9449381)
    4(1193094-1202271)


    ENSEMBL Gene Tree for ZNF853 (if available)
    TreeFam Gene Tree for ZNF853 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZNF853 gene
    ZNF7872  YY22  ZFP422  YY12  
    Selected SIMAP similar genes for ZNF853 using alignment to 2 protein entries:     ZN853_HUMAN (see all proteins) (see all similar genes):
    ZFS-4    ZNF818P    ZNF154    DKFZp666C237    ZNF514    ZNF586
    ZNF697    DKFZp686O111    GLI4    ZFS-5    ZNF78L1    HZF36
    ZNF146    ZNF260    ZNF35    ZNF570    ZNF585B    zf30

    ZNF853 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZNF853 (see all 197)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1420429591,2
    --6626171(+) TTAAGA/TTGGGA 1 -- us2k10--------
    rs1865390061,2
    --6626183(+) AGCCCC/TGAGGA 1 -- us2k10--------
    rs1918980971,2
    --6626350(+) CTGCTC/TGTCCT 1 -- us2k10--------
    rs624413171,2
    C,F--6626393(+) ACAGAC/TGCAAG 1 -- us2k17Minor allele frequency- T:0.31NA CSA WA EA 365
    rs1511721401,2
    --6626395(+) AGACGC/TAAGGC 1 -- us2k10--------
    rs799362671,2
    C,F--6653647(+) TCAGGC/AAAGGG 1 -- us2k11Minor allele frequency- A:0.05EA 120
    rs1175026041,2
    C,F--6653703(+) ATTCCA/CAAAAC 1 -- us2k11Minor allele frequency- C:0.03NA 120
    rs567573371,2
    C--6653783(+) CCCTGA/GGGGCT 1 -- us2k13Minor allele frequency- G:0.09CSA WA NA 240
    rs1390683631,2
    C--6653985(+) GGTGAC/TCTGCC 1 -- us2k10--------
    rs1831867311,2
    --6654245(+) AGATGC/GGGTCT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ZNF853 (6655248 - 6663921 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for ZNF853 (see all 11):    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv436904CNV Insertion17901297
    dgv7149n71CNV Loss21882294
    dgv7150n71CNV Loss21882294
    nsv830895CNV Loss17160897
    dgv7148n71CNV Loss21882294
    dgv7147n71CNV Loss21882294
    nsv515978CNV Loss19592680
    nsv508444CNV Loss20534489
    dgv1090n67CNV Gain20364138
    esv1914954OTHER Inversion16254605

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZNF853 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with ZNF853)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (Nature 2003)
    2. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)1 Dephoure N.... Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 54753 HGNC: 21767 AceView: DKFZp434J1015 Ensembl:ENSG00000236609 euGenes: HUgn54753
    ECgene: ZNF853 H-InvDB: ZNF853

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZNF853 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZNF853 gene:
    Search GeneIP for patents involving ZNF853

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF853
     Browse SwitchGear 3'UTR luciferase reporter plasmids for ZNF853
     Browse SwitchGear Promoter luciferase reporter plasmids for ZNF853
     Search ThermoFisher Antibodies for ZNF853
     Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat ZNF853
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ZNF853
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ZNF853
     LSBio Antibodies in human, mouse, rat for ZNF853
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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