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ZNF850 Gene

protein-coding   GIFtS: 31
GCID: GC19M037367

Zinc Finger Protein 850

(Previous names: zinc finger protein 850 pseudogene, zinc finger protein...)
(Previous symbol: ZNF850P)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger Protein 8501 2
ZNF850P1 2
Zinc Finger Protein 850 (Pseudogene)1
Zinc Finger Protein 850 Pseudogene1
Putative Zinc Finger Protein ENSP000003309942

External Ids:    HGNC: 279941   Entrez Gene: 3428922   Ensembl: ENSG000002670417   UniProtKB: A8MQ143   

Export aliases for ZNF850 gene to outside databases

Previous GC identifer: GC19M037241


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZNF850 Gene:
ZNF850 (zinc finger protein 850) is a protein-coding gene. An important paralog of this gene is ZNF91.

UniProtKB/Swiss-Prot: ZN850_HUMAN, A8MQ14
Function: May be involved in transcriptional regulation (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NT_011109.17  NC_018930.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for ZNF850
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for ZNF850

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF850


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.12   Ensembl cytogenetic band:  19q13.12   HGNC cytogenetic band: 19q13.12

ZNF850 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF850 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M037367:  view genomic region     (about GC identifiers)

Start:
37,205,285 bp from pter      End:
37,263,727 bp from pter
Size:
58,443 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ZN850_HUMAN, A8MQ14 (See protein sequence)
Recommended Name: Zinc finger protein 850  
Size: 1090 amino acids; 125431 Da

Explore the universe of human proteins at neXtProt for ZNF850: NX_A8MQ14

Explore proteomics data for ZNF850 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ZNF850 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001180481.1  NP_001254708.1  

    ENSEMBL proteins: 
     ENSP00000465189   ENSP00000464976  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR001909 Krueppel-associated_box
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry A8MQ14

    ProtoNet protein and cluster: A8MQ14

    UniProtKB/Swiss-Prot: ZN850_HUMAN, A8MQ14
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 32 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    Find genes that share domains with ZNF850           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN850_HUMAN, A8MQ14
    Function: May be involved in transcriptional regulation (By similarity)

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with ZNF850           About GenesLikeMe


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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZN850_HUMAN, A8MQ14: Nucleus (By similarity)

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--

    Find genes that share ontologies with ZNF850           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF850
    Interactions:

        Search GeneGlobe Interaction Network for ZNF850

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--

    Find genes that share ontologies with ZNF850           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZNF850 (ZN850)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ZNF850 gene (2 alternative transcripts): 
    NM_001193552.1  NM_001267779.1  

    Unigene Cluster for ZNF850:

    Zinc finger protein 850
    Hs.406307  [show with all ESTs]
    Unigene Representative Sequence: NM_001193552
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000589390 ENST00000591344
    miRNA
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    Additional mRNA sequence: 

    BC052603.1 BC136266.1 BC143637.1 CR627133.1 

    6 DOTS entries:

    DT.121502829  DT.102824818  DT.100009866  DT.309547  DT.92418839  DT.92009575 

    6 AceView cDNA sequences:

    BU185502 BC052603 BU163412 AW440392 BE407543 BE281270 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZNF850 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGTGTCAGGA
    ZNF850 Expression
    About this image

    ZNF850 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZNF850 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.406307
        Custom PCR Arrays for ZNF850
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF850

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ZNF850 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gm72215 predicted gene 7221   --   7 (28.25 cM) -
    chicken
    (Gallus gallus)
    Aves LOC1017512271 zinc finger protein 792-like 55.79(n)
    50.3(a)
      101751227  XM_004950673.1  XP_004950730.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 57)
    Uncharacterized protein
    (see all 57)
    56(a)
    55(a)
    (see all 57)
    many ↔ many
    many ↔ many
    (see all 57)
    GL343773.1(15895-27886)
    GL343931.1(39051-65856)
    zebrafish
    (Danio rerio)
    Actinopterygii BX942815.16
    zgc:1714186
    (see all 32)
    zgc:171418
    (see all 32)
    51(a)
    50(a)
    (see all 32)
    many ↔ many
    many ↔ many
    (see all 32)
    8(40886424-40976655) ENSDARG00000075317
    3(11648176-11681259) ENSDARG00000088051
    fruit fly
    (Drosophila melanogaster)
    Insecta Oaz6
    O/E-associated zinc finger protein
    12(a)
    1 → many
    2R(10323404-10353386)


    ENSEMBL Gene Tree for ZNF850 (if available)
    TreeFam Gene Tree for ZNF850 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZNF850 gene
    ZNF912  ZNF5212  PEG32  ZNF7292  ZNF4232  ZNF2082  
    Selected SIMAP similar genes for ZNF850 using alignment to 2 protein entries:     ZN850_HUMAN (see all proteins) (see all similar genes):
    ZNF420    ZNF78L1    ZNF283    ZNF738    ZNF93    DKFZp313M0722
    ZNF323    ZSCAN16    ZNF625    DKFZp686H10254    FIK    ZNF546
    ZNF649    ZSCAN21    ZNF83    ZNF81    ZNF140    ZNF761

    Find genes that share paralogs with ZNF850           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZNF850 (see all 471)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1445626221,2
    --37233900(+) AAATTC/GTTTTA 2 -- ds5001 int10--------
    rs1927768041,2
    --37233977(+) AGGAAC/TAATGG 2 -- ds5001 int10--------
    rs72503761,2
    C,F,A,H--37233978(+) ggaacG/Aatggc 2 -- ds5001 int114Minor allele frequency- A:0.22NS EA NA WA CSA 751
    rs1849392501,2
    --37234002(+) CCCAGA/CACTTC 2 -- ds5001 int10--------
    rs1478503161,2
    --37234031(+) GATGGC/TTTGAG 2 -- ds5001 int10--------
    rs1894489821,2
    --37234048(+) AGTTCA/GACAGT 2 -- ds5001 int10--------
    rs1921574361,2
    --37234135(+) CCAGGG/TACTTG 2 -- ds5001 int10--------
    rs1161699551,2
    F--37234157(+) TGGAAG/AGACTG 2 -- ds5001 int11Minor allele frequency- A:0.01WA 118
    rs104080631,2
    C,F--37234191(+) gcagtG/Aagcag 2 -- ds5001 int14Minor allele frequency- A:0.16WA CSA 123
    rs114214841,2
    C--37234257(+) AAAAA-/A/CAC 
            
    CACCA
    4 -- ds5001 cds1 int10--------

    HapMap Linkage Disequilibrium report for ZNF850 (37205285 - 37263727 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for ZNF850:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2718509CNV Deletion23290073
    esv271514CNV Insertion20981092
    nsv911649CNV Loss21882294
    nsv817833CNV Loss17921354
    nsv521605CNV Loss19592680
    nsv470139CNV Loss18288195
    esv34384CNV Loss17911159
    nsv911650CNV Gain21882294
    nsv469794CNV Complex16826518

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing ZNF850
    DNA2.0 Custom Variant and Variant Library Synthesis for ZNF850

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZNF850 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with ZNF850)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    2. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    3. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (Nature 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 342892 HGNC: 27994 AceView: LOC342892 Ensembl:ENSG00000267041 euGenes: HUgn342892
    ECgene: ZNF850 H-InvDB: ZNF850

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ZNF850 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZNF850 gene:
    Search GeneIP for patents involving ZNF850

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

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