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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZNF850 Gene

protein-coding   GIFtS: 32
GCID: GC19M037241

Zinc Finger Protein 850

(Previous names: zinc finger protein 850 pseudogene, zinc finger protein...)
(Previous symbol: ZNF850P)
  Search for ZNF850
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Zinc Finger Protein 8501 2
ZNF850P1 2
Zinc Finger Protein 850 (Pseudogene)1
Zinc Finger Protein 850 Pseudogene1
Putative Zinc Finger Protein ENSP000003309942

External Ids:    HGNC: 279941   Entrez Gene: 3428922   Ensembl: ENSG000002670417   UniProtKB: A8MQ143   

Export aliases for ZNF850 gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ZNF850 Gene: 
ZNF850 (zinc finger protein 850) is a protein-coding gene. GO annotations related to this gene include DNA binding and zinc ion binding. An important paralog of this gene is ZNF91.

UniProtKB/Swiss-Prot: ZN850_HUMAN, A8MQ14
Function: May be involved in transcriptional regulation (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NT_011109.16  NC_018930.2  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for ZNF850
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for ZNF850

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF850


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.12   Ensembl cytogenetic band:  19q13.12   HGNC cytogenetic band: 19q13.12

ZNF850 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF850 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M037241:  view genomic region     (about GC identifiers)

Start:
37,205,285 bp from pter      End:
37,263,727 bp from pter
Size:
58,443 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZN850_HUMAN, A8MQ14 (See protein sequence)
Recommended Name: Zinc finger protein 850  
Size: 1090 amino acids; 125431 Da
Subcellular location: Nucleus (By similarity)

Explore the universe of human proteins at neXtProt for ZNF850: NX_A8MQ14

Explore proteomics data for ZNF850 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_A8MQ14

  • ZNF850 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ZNF850 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001180481.1  NP_001254708.1  

    ENSEMBL proteins: 
     ENSP00000465189   ENSP00000464976  

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    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--

    ZNF850 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR001909 Krueppel-associated_box
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry A8MQ14

    ProtoNet protein and cluster: A8MQ14

    UniProtKB/Swiss-Prot: ZN850_HUMAN, A8MQ14
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 32 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    ZNF850 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN850_HUMAN, A8MQ14
    Function: May be involved in transcriptional regulation (By similarity)

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0008270zinc ion binding ----
    GO:0046872metal ion binding IEA--
         
    ZNF850 for ontologies           About GeneDecksing


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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF850

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--

    ZNF850 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for ZNF850 (ZN850)

    Search CenterWatch for drugs/clinical trials and news about ZNF850 / ZN850

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    About This Section

    REFSEQ mRNAs for ZNF850 gene (2 alternative transcripts): 
    NM_001193552.1  NM_001267779.1  

    Unigene Cluster for ZNF850:

    Zinc finger protein 850
    Hs.406307  [show with all ESTs]
    Unigene Representative Sequence: NM_001193552
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000589390 ENST00000591344
    miRNA
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    Additional mRNA sequence: 

    BC052603.1 BC136266.1 BC143637.1 CR627133.1 

    6 DOTS entries:

    DT.121502829  DT.102824818  DT.100009866  DT.309547  DT.92418839  DT.92009575 

    6 AceView cDNA sequences:

    BU163412 BU185502 BC052603 AW440392 BE407543 BE281270 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZNF850 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGTGTCAGGA
    ZNF850 Expression
    About this image


    See ZNF850 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZNF850

    SOURCE GeneReport for Unigene cluster: Hs.406307
        SABiosciences Custom PCR Arrays for ZNF850
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF850

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for ZNF850 gene from 3/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gm72215
    Zfp33b1
    predicted gene 72215
    zinc finger protein 33B1
    59.28(n)1
    51.87(a)1
      7 (28.25 cM)5
    696231  XM_001487796.41  XP_001487846.41 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 116)
    --
    60(a)
    60(a)
    (see all 116)
    possible ortholog
    possible ortholog
    (see all 116)
    AAWZ02037426(981-2798)
    GL344817.1(7665-9254)
    zebrafish
    (Danio rerio)
    Actinopterygii CU929205.16
    AL935044.26
    (see all 3)
    Uncharacterized protein
    (see all 3)
    50(a)
    40(a)
    (see all 3)
    possible ortholog
    possible ortholog
    (see all 3)
    3(62175907-62185073)
    24(16413099-16429687)


    ENSEMBL Gene Tree for ZNF850 (if available)
    TreeFam Gene Tree for ZNF850 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZNF850 gene
    ZNF912  ZNF7212  ZNF5212  ZNF6462  ZNF7292  ZNF4232  ZNF2082  
    18/543 SIMAP similar genes for ZNF850 using alignment to 2 protein entries:     ZN850_HUMAN (see all proteins) (see all similar genes):
    ZNF420    ZNF78L1    ZNF283    ZNF738    ZNF93    DKFZp313M0722
    ZNF323    ZSCAN16    ZNF625    DKFZp686H10254    FIK    ZNF546
    ZNF649    ZSCAN21    ZNF83    ZNF81    ZNF140    ZNF761

    ZNF850 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/471 SNPs in ZNF850 are shown (see all 471)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1445626221,2
    --37233900(+) AAATTC/GTTTTA 2 -- ds5001 int10--------
    rs1927768041,2
    --37233977(+) AGGAAC/TAATGG 2 -- ds5001 int10--------
    rs72503761,2
    C,F,A,H--37233978(+) ggaacG/Aatggc 2 -- ds5001 int114Minor allele frequency- A:0.22NS EA NA WA CSA 751
    rs1849392501,2
    --37234002(+) CCCAGA/CACTTC 2 -- ds5001 int10--------
    rs1478503161,2
    --37234031(+) GATGGC/TTTGAG 2 -- ds5001 int10--------
    rs1894489821,2
    --37234048(+) AGTTCA/GACAGT 2 -- ds5001 int10--------
    rs1921574361,2
    --37234135(+) CCAGGG/TACTTG 2 -- ds5001 int10--------
    rs1161699551,2
    F--37234157(+) TGGAAG/AGACTG 2 -- ds5001 int11Minor allele frequency- A:0.01WA 118
    rs104080631,2
    C,F--37234191(+) gcagtG/Aagcag 2 -- ds5001 int14Minor allele frequency- A:0.16WA CSA 123
    rs114214841,2
    C--37234257(+) AAAAA-/A/CAC 
            
    CACCA
    4 -- ds5001 cds1 int10--------

    HapMap Linkage Disequilibrium report for ZNF850 (37205285 - 37263727 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for ZNF850:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2718509CNV Deletion23290073
    esv271514CNV Insertion20981092
    nsv911649CNV Loss21882294
    nsv817833CNV Loss17921354
    nsv521605CNV Loss19592680
    nsv470139CNV Loss18288195
    esv34384CNV Loss17911159
    nsv911650CNV Gain21882294
    nsv469794CNV Complex16826518

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZNF850 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ZNF850)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    2. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    3. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 342892 HGNC: 27994 AceView: LOC342892 Ensembl:ENSG00000267041 euGenes: HUgn342892
    ECgene: ZNF850 H-InvDB: ZNF850

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZNF850 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZNF850 gene:
    Search GeneIP for patents involving ZNF850

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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