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Aliases for ZNF85 Gene

Aliases for ZNF85 Gene

  • Zinc Finger Protein 85 2 3 5
  • Zinc Finger Protein 85 (HPF4, HTF1) 2 3
  • Zinc Finger Protein HPF4 4
  • Zinc Finger Protein HTF1 4
  • HPF4 3
  • HTF1 3

External Ids for ZNF85 Gene

Previous GeneCards Identifiers for ZNF85 Gene

  • GC19P021544
  • GC19P021425
  • GC19P020882
  • GC19P020767
  • GC19P020897
  • GC19P021106
  • GC19P020597

Summaries for ZNF85 Gene

GeneCards Summary for ZNF85 Gene

ZNF85 (Zinc Finger Protein 85) is a Protein Coding gene. Diseases associated with ZNF85 include Heparin-Induced Thrombocytopenia. GO annotations related to this gene include nucleic acid binding and transcription corepressor activity. An important paralog of this gene is ZNF718.

UniProtKB/Swiss-Prot for ZNF85 Gene

  • May be a transcriptional repressor.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF85 Gene

Genomics for ZNF85 Gene

Regulatory Elements for ZNF85 Gene

Enhancers for ZNF85 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZNF85 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF85 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF85 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF85 Gene

Chromosome:
19
Start:
20,923,221 bp from pter
End:
20,950,697 bp from pter
Size:
27,477 bases
Orientation:
Plus strand

Genomic View for ZNF85 Gene

Genes around ZNF85 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF85 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF85 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF85 Gene

Proteins for ZNF85 Gene

  • Protein details for ZNF85 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q03923-ZNF85_HUMAN
    Recommended name:
    Zinc finger protein 85
    Protein Accession:
    Q03923
    Secondary Accessions:
    • B9ZVP4
    • Q6NVI0

    Protein attributes for ZNF85 Gene

    Size:
    595 amino acids
    Molecular mass:
    68736 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF85 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF85 Gene

Proteomics data for ZNF85 Gene at MOPED

Post-translational modifications for ZNF85 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF85 Gene

Domains & Families for ZNF85 Gene

Gene Families for ZNF85 Gene

Protein Domains for ZNF85 Gene

Suggested Antigen Peptide Sequences for ZNF85 Gene

Graphical View of Domain Structure for InterPro Entry

Q03923

UniProtKB/Swiss-Prot:

ZNF85_HUMAN :
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 16 C2H2-type zinc fingers.
Domain:
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 16 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF85: view

Function for ZNF85 Gene

Molecular function for ZNF85 Gene

GENATLAS Biochemistry:
zinc finger protein (HPF4,HTF1) KRAB subfamily,member of ZNF91 family,expressed in normal adult testis and in seminomas
UniProtKB/Swiss-Prot Function:
May be a transcriptional repressor.

Gene Ontology (GO) - Molecular Function for ZNF85 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding TAS 9839802
GO:0003714 transcription corepressor activity TAS 9839802
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with ZNF85: view
genes like me logo Genes that share phenotypes with ZNF85: view

Animal Model Products

CRISPR Products

miRNA for ZNF85 Gene

miRTarBase miRNAs that target ZNF85

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF85 Gene

Localization for ZNF85 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF85 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF85 Gene COMPARTMENTS Subcellular localization image for ZNF85 gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for ZNF85 Gene

Pathways & Interactions for ZNF85 Gene

SuperPathways for ZNF85 Gene

No Data Available

Interacting Proteins for ZNF85 Gene

Gene Ontology (GO) - Biological Process for ZNF85 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903507 negative regulation of nucleic acid-templated transcription TAS 9839802
genes like me logo Genes that share ontologies with ZNF85: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF85 Gene

Drugs & Compounds for ZNF85 Gene

(1) Drugs for ZNF85 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with ZNF85: view

Transcripts for ZNF85 Gene

Unigene Clusters for ZNF85 Gene

Zinc finger protein 85:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF85 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d
SP1: - -
SP2: - - - - - -
SP3: -
SP4: - -
SP5: - - - - - - -
SP6: - - - -

Relevant External Links for ZNF85 Gene

GeneLoc Exon Structure for
ZNF85
ECgene alternative splicing isoforms for
ZNF85

Expression for ZNF85 Gene

mRNA expression in normal human tissues for ZNF85 Gene

mRNA differential expression in normal tissues according to GTEx for ZNF85 Gene

This gene is overexpressed in Testis (x6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF85 Gene



SOURCE GeneReport for Unigene cluster for ZNF85 Gene Hs.37138

mRNA Expression by UniProt/SwissProt for ZNF85 Gene

Q03923-ZNF85_HUMAN
Tissue specificity: Widely expressed, including in testis.
genes like me logo Genes that share expression patterns with ZNF85: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues and Protein tissue co-expression partners for ZNF85 Gene

Orthologs for ZNF85 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF85 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF85 35
  • 99.09 (n)
  • 98.39 (a)
ZNF85 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 58 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 42 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 43 (a)
ManyToMany
-- 36
  • 52 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Zfp493 36
  • 58 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 54 (a)
ManyToMany
-- 36
  • 39 (a)
ManyToMany
-- 36
  • 46 (a)
ManyToMany
-- 36
  • 41 (a)
ManyToMany
-- 36
  • 36 (a)
ManyToMany
-- 36
  • 36 (a)
ManyToMany
-- 36
  • 35 (a)
ManyToMany
-- 36
  • 30 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii wufc22b08 35
fruit fly
(Drosophila melanogaster)
Insecta bowl 37
  • 46 (a)
CG10147 37
  • 36 (a)
CG18764 37
  • 43 (a)
CG7386 37
  • 30 (a)
EG:95B7.7 37
  • 32 (a)
sob 37
  • 46 (a)
Species with no ortholog for ZNF85:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF85 Gene

ENSEMBL:
Gene Tree for ZNF85 (if available)
TreeFam:
Gene Tree for ZNF85 (if available)

Paralogs for ZNF85 Gene

Pseudogenes.org Pseudogenes for ZNF85 Gene

genes like me logo Genes that share paralogs with ZNF85: view

Variants for ZNF85 Gene

Sequence variations from dbSNP and Humsavar for ZNF85 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
VAR_033552 -
VAR_033553 -
VAR_033554 -
VAR_047515 -
VAR_061932 -

Structural Variations from Database of Genomic Variants (DGV) for ZNF85 Gene

Variant ID Type Subtype PubMed ID
dgv3794n71 CNV Loss 21882294
nsv458377 CNV Gain 19166990
dgv201n21 CNV Loss 19592680
nsv509727 CNV Insertion 20534489
nsv2438 CNV Insertion 18451855

Variation tolerance for ZNF85 Gene

Residual Variation Intolerance Score: 97.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.95; 59.76% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ZNF85 Gene

Disorders for ZNF85 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZNF85 Gene - From: GeneCards

Disorder Aliases PubMed IDs
heparin-induced thrombocytopenia
  • hit
- elite association - COSMIC cancer census association via MalaCards
Search ZNF85 in MalaCards View complete list of genes associated with diseases

Relevant External Links for ZNF85

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF85
genes like me logo Genes that share disorders with ZNF85: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF85 Gene

Publications for ZNF85 Gene

  1. Functional analysis of ZNF85 KRAB zinc finger protein, a member of the highly homologous ZNF91 family. (PMID: 9839802) Poncelet D.A. … Martial J.A. (DNA Cell Biol. 1998) 3 4 23 67
  2. The human genome contains hundreds of genes coding for finger proteins of the Kruppel type. (PMID: 2505992) Bellefroid E.J. … Martial J.A. (DNA 1989) 2 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. An update on the prevalence and characterization of H-PF4 antibodies in Asian-Indian patients. (PMID: 19452409) Kannan M. … Fareed J. (Semin. Thromb. Hemost. 2009) 23
  5. Heparin-induced thrombocytopenia: diagnosis and management. (PMID: 18544310) Liebman H.A. (Vascular 2008) 23

Products for ZNF85 Gene

Sources for ZNF85 Gene

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