ZNF85 Gene
protein-coding GIFtS: 49
GCID: GC19P021106
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zinc finger protein 85(Previous names: zinc finger protein 85 (HPF4, HTF1) )
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Aliases
for ZNF85 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger Protein 851 2 | | HPF41 2 | | HTF11 2 | | Zinc Finger Protein 85 (HPF4, HTF1)1 2 | | Zinc Finger Protein HPF43 | | Zinc Finger Protein HTF13 |
Export aliases for ZNF85 gene to outside databasesPrevious GC identifers: GC19P021544 GC19P021425 GC19P020882 GC19P020767 GC19P020897 GC19P020597 |
Summaries
for ZNF85 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: ZNF85_HUMAN, Q03923Function: May be a transcriptional repressor
|
Genomic Views
for ZNF85 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011295.11
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZNF85 gene promoter:
NF-YB CBF-B CBF-A NF-YA CP1A NF-Y CBF(2)
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZNF85
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF85 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19p12 Ensembl cytogenetic band: 19p12 HGNC cytogenetic band: 19p12ZNF85 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P021106: view genomic region
(about GC identifiers)
Start:
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21,106,059 bp from pter |
End:
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21,133,503 bp from pter |
Size:
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27,445 bases |
Orientation:
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plus strand |
1 alternative location:
| Chr19+,PATCHES 21,109,267-21,136,711 |
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Proteins
for ZNF85 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZNF85_HUMAN, Q03923 (See
protein sequence)Recommended Name: Zinc finger protein 85 Size: 595 amino acids; 68736 Da
Subcellular location: Nucleus
Secondary accessions: B9ZVP4 Q6NVI0Alternative splicing: 3 isoforms: Q03923-1 Q03923-2 Q03923-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for ZNF85: NX_Q03923
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q03923
ZNF85 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (4 alternative transcripts):
NP_001243100.1 NP_001243101.1 NP_001243102.1 NP_003420.2
ENSEMBL proteins: ENSP00000329793 ENSP00000342340 ENSP00000300540
Human Recombinant Protein Products for ZNF85:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
ZNF85 for ontologies About GeneDecksing
ZNF85 Antibody Products:
Assay Products for ZNF85: |
Protein
Domains /
Families
for ZNF85 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZNF85 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q03923ProtoNet protein and cluster: Q03923 2 Blocks protein families: IPB001909 KRAB box IPB007086 C2H2-type zinc finger signature
UniProtKB/Swiss-Prot: ZNF85_HUMAN, Q03923Similarity: Belongs to the krueppel C2H2-type zinc-finger protein familySimilarity: Contains 16 C2H2-type zinc fingersSimilarity: Contains 1 KRAB domain |
Function
for ZNF85 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: ZNF85_HUMAN, Q03923Function: May be a transcriptional repressor Genatlas biochemistry entry for ZNF85:zinc finger protein (HPF4,HTF1) KRAB subfamily,member of ZNF91 family,expressed in normal adult testis and in seminomas
Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table
ZNF85 for ontologies About GeneDecksing
Phenotypes:
1 GenomeRNAi human phenotype for ZNF85:
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF85
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF85 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: ZNF85 (NM_003429) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF85 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF85 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF85 |
|
Pathways & Interactions
for ZNF85 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF85
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
-- | -- |
ZNF85 for ontologies About GeneDecksing
|
Drugs & Compounds
for ZNF85 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
ZNF85 for compounds About GeneDecksing
 Browse Tocris compounds for ZNF85
1 Novoseek chemical compound relationship for ZNF85 gene About this table
Search CenterWatch for drugs/clinical trials and news about ZNF85
|
Transcripts
for ZNF85 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZNF85 gene (4 alternative transcripts): NM_001256171.1 NM_001256172.1 NM_001256173.1 NM_003429.4 Unigene Cluster for ZNF85: Zinc finger protein 85 Hs.37138 [show with all ESTs]Unigene Representative Sequence: BC0363943 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000328178(uc002npg.4 uc010ecn.3 uc010eco.3 uc002npi.3)
ENST00000345030 ENST00000300540(uc002npf.3 uc002nph.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF85
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF85 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ZNF85 (NM_003429) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF85 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF85 |
Additional cDNA sequence: AK308258.1 BC008688.1 BC036394.1 BC047646.1 BC068066.1 D70831.1 M61866.1 M61868.1 NR_045830.1 U35376.1 13 DOTS entries: DT.92431200 DT.92044530 DT.100702930 DT.92414322 DT.100000539 DT.121496517 DT.87004303 DT.87014749 DT.95368438 DT.121496408 DT.121496445 DT.121496672 DT.95114454 24/35 AceView cDNA sequences (see all 35): BM788849 H94743 BC068066 BG030684 BC047646 CA418053 BU620315 BG718610 M61868 BU147159 CA442806 BU680760 W02127 BM801965 AI253261 BI560594 BQ217962 BF699661 BX356542 BX344988 AA337346 BX356543 BG721813 BQ010634
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF85 (see all 6) About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | · | 7c | · | 7d |
|---|
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| SP1: | | | | | | | - | | - | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | - | | - | | - | | - | | - | | - | | | | | | | | | | |
| SP3: | | | | | | | | | | | - | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | - | | - | | | | | | | | | | | | | | |
| SP5: | | | | | - | | - | | - | | - | | - | | - | | - | | | | | | | | | |
ECgene alternative splicing isoforms for ZNF85
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Expression
for ZNF85 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZNF85 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGAAGAATGT
About this image
See ZNF85 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZNF85
SOURCE GeneReport for Unigene cluster: Hs.37138
UniProtKB/Swiss-Prot: ZNF85_HUMAN, Q03923Tissue specificity: Widely expressed, including in testis
SABiosciences Custom PCR Arrays for ZNF85
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF85
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat ZNF85 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF85 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF85 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF85 |
Orthologs
for ZNF85 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for ZNF85 gene from 2/6 species (see all 6) About this table
ENSEMBL Gene Tree for ZNF85 (if available)
TreeFam Gene Tree for ZNF85 (if available) |
Paralogs
for ZNF85 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ZNF85 gene
- ZNF4932 ZNF4862 ZNF1002 ZNF922 ZNF7322 ZNF1382 ZNF6752 ZNF5062
- ZNF2732 ZNF66P2 ZNF6952 ZNF6262 ZNF6802 ZNF2532 ZNF4792 ZNF932
- ZNF4922 ZNF6822 ZNF6762 ZNF1412 ZNF6812 ZNF6792 ZNF2572 ZNF2542
- ZNF7372 ZNF724P2 ZNF982 ZNF849P2 ZNF7162 ZNF7142 ZNF4292 ZNF4302
- ZNF7302 ZNF6782 ZNF1172 ZNF7082 ZNF1072 ZNF4312 ZNF902
18/525 SIMAP similar genes for ZNF85 using alignment to 12 protein entries: ZNF85_HUMAN (see all proteins)
(see all similar genes):ZFS-1 MGC12518 kr-znf3 ZNF273 DKFZp762K012 ZFS-6
ZNF66 ZNF818P ZNF708 ZNF724P DKFZp686M04222 ZNF737
smap-7 ZNF100 ZNF626 ZNF506 ZNF738 ZNF675
ZNF85 for paralogs About GeneDecksing
4 Pseudogenes.org Pseudogenes for ZNF85
PGOHUM00000234554 PGOHUM00000250598 PGOHUM00000234640 PGOHUM00000232727
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Genomic Variants
for ZNF85 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZNF85 (21106059 - 21133503 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for ZNF85
1 CNV: 78137 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF85 |
|
Disorders
/ Diseases
for ZNF85 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ZNF85 for disorders About GeneDecksing
OMIM gene information: 603899
OMIM disorders: --
5  diseases for ZNF85: About MalaCardsheparin-induced thrombocytopenia testis seminoma thrombocytopenia seminoma
thrombosis
2 Novoseek disease relationships for ZNF85 gene About this table
Export disorders for ZNF85 gene to outside databases
|
Publications
for ZNF85 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZNF85 gene, integrated from 9 sources (see all 23):
(articles sorted by number of sources associating them with ZNF85) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Functional analysis of ZNF85 KRAB zinc finger protein, a member of the highly homologous ZNF91 family. (PubMed id 9839802)1, 2, 9 Poncelet D.A.... Martial J.A. (1998)
- The evolutionarily conserved Kruppel-associated box domain defines a subfamily of eukaryotic multifingered proteins. (PubMed id 2023909)1, 2 Bellefroid E.J....Martial J.A. (1991)
- The human genome contains hundreds of genes coding for finger proteins of the Kruppel type. (PubMed id 2505992)1, 3 Bellefroid E.J....Martial J.A. (1989)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- Transcriptome analysis of human gastric cancer. (PubMed id 16341674)1 Oh J.H....Kim N.S. (2005)
- Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PubMed id 15342556)1 Suzuki Y.... Sugano S. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for ZNF85 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZNF85 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZNF85 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZNF85 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZNF85 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZNF85 gene:
Search GeneIP for patents involving ZNF85
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZNF85 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF85 |
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