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Aliases for ZNF85 Gene

Aliases for ZNF85 Gene

  • Zinc Finger Protein 85 2 3
  • Zinc Finger Protein 85 (HPF4, HTF1) 2 3
  • Zinc Finger Protein HPF4 4
  • Zinc Finger Protein HTF1 4
  • HPF4 3
  • HTF1 3

External Ids for ZNF85 Gene

Previous GeneCards Identifiers for ZNF85 Gene

  • GC19P021544
  • GC19P021425
  • GC19P020882
  • GC19P020767
  • GC19P020897
  • GC19P021106
  • GC19P020597

Summaries for ZNF85 Gene

GeneCards Summary for ZNF85 Gene

ZNF85 (Zinc Finger Protein 85) is a Protein Coding gene. Diseases associated with ZNF85 include anteroseptal myocardial infarction. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and transcription corepressor activity. An important paralog of this gene is ZNF253.

UniProtKB/Swiss-Prot for ZNF85 Gene

  • May be a transcriptional repressor.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF85 Gene

Genomics for ZNF85 Gene

Regulatory Elements for ZNF85 Gene

Genomic Location for ZNF85 Gene

Start:
20,923,222 bp from pter
End:
20,950,697 bp from pter
Size:
27,476 bases
Orientation:
Plus strand

Genomic View for ZNF85 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF85 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF85 Gene

Proteins for ZNF85 Gene

  • Protein details for ZNF85 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q03923-ZNF85_HUMAN
    Recommended name:
    Zinc finger protein 85
    Protein Accession:
    Q03923
    Secondary Accessions:
    • B9ZVP4
    • Q6NVI0

    Protein attributes for ZNF85 Gene

    Size:
    595 amino acids
    Molecular mass:
    68736 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF85 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF85 Gene

Proteomics data for ZNF85 Gene at MOPED

Post-translational modifications for ZNF85 Gene

  • Ubiquitination at Lys511
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ZNF85 Gene

Domains for ZNF85 Gene

Gene Families for ZNF85 Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type

Suggested Antigen Peptide Sequences for ZNF85 Gene

Graphical View of Domain Structure for InterPro Entry

Q03923

UniProtKB/Swiss-Prot:

ZNF85_HUMAN :
  • Q03923
Domain:
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 16 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF85: view

Function for ZNF85 Gene

Molecular function for ZNF85 Gene

GENATLAS Biochemistry: zinc finger protein (HPF4,HTF1) KRAB subfamily,member of ZNF91 family,expressed in normal adult testis and in seminomas
UniProtKB/Swiss-Prot Function: May be a transcriptional repressor.

Gene Ontology (GO) - Molecular Function for ZNF85 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0003700 sequence-specific DNA binding transcription factor activity TAS 9839802
GO:0003714 transcription corepressor activity TAS 9839802
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with ZNF85: view

Phenotypes for ZNF85 Gene

GenomeRNAi human phenotypes for ZNF85:
genes like me logo Genes that share phenotypes with ZNF85: view

Animal Model Products

CRISPR Products

miRNA for ZNF85 Gene

miRTarBase miRNAs that target ZNF85

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ZNF85 Gene

Localization for ZNF85 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF85 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF85 Gene COMPARTMENTS Subcellular localization image for ZNF85 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF85 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with ZNF85: view

Pathways for ZNF85 Gene

SuperPathways for ZNF85 Gene

No Data Available

Interacting Proteins for ZNF85 Gene

Gene Ontology (GO) - Biological Process for ZNF85 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:1903507 negative regulation of nucleic acid-templated transcription TAS 9839802
genes like me logo Genes that share ontologies with ZNF85: view

No data available for Pathways by source for ZNF85 Gene

Compounds for ZNF85 Gene

(1) Novoseek inferred chemical compound relationships for ZNF85 Gene

Compound -log(P) Hits PubMed IDs
heparin 66.7 14
genes like me logo Genes that share compounds with ZNF85: view

Transcripts for ZNF85 Gene

Unigene Clusters for ZNF85 Gene

Zinc finger protein 85:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF85

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for ZNF85
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF85 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d
SP1: - -
SP2: - - - - - -
SP3: -
SP4: - -
SP5: - - - - - - -
SP6: - - - -

Relevant External Links for ZNF85 Gene

GeneLoc Exon Structure for
ZNF85
ECgene alternative splicing isoforms for
ZNF85

Expression for ZNF85 Gene

mRNA expression in normal human tissues for ZNF85 Gene

mRNA differential expression in normal tissues according to GTEx for ZNF85 Gene

This gene is overexpressed in Testis (6.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ZNF85 Gene

SOURCE GeneReport for Unigene cluster for ZNF85 Gene Hs.37138

mRNA Expression by UniProt/SwissProt for ZNF85 Gene

Q03923-ZNF85_HUMAN
Tissue specificity: Widely expressed, including in testis.
genes like me logo Genes that share expressions with ZNF85: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for ZNF85 Gene

Orthologs for ZNF85 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF85 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF85 35
  • 99.09 (n)
  • 98.39 (a)
ZNF85 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 58 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 42 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Zfp493 36
  • 58 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 43 (a)
ManyToMany
-- 36
  • 52 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 54 (a)
ManyToMany
-- 36
  • 39 (a)
ManyToMany
-- 36
  • 46 (a)
ManyToMany
-- 36
  • 41 (a)
ManyToMany
-- 36
  • 36 (a)
ManyToMany
-- 36
  • 36 (a)
ManyToMany
-- 36
  • 35 (a)
ManyToMany
-- 36
  • 30 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii wufc22b08 35
fruit fly
(Drosophila melanogaster)
Insecta CG10147 37
  • 36 (a)
sob 37
  • 46 (a)
EG:95B7.7 37
  • 32 (a)
CG18764 37
  • 43 (a)
bowl 37
  • 46 (a)
CG7386 37
  • 30 (a)
Species with no ortholog for ZNF85:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF85 Gene

ENSEMBL:
Gene Tree for ZNF85 (if available)
TreeFam:
Gene Tree for ZNF85 (if available)

Paralogs for ZNF85 Gene

Pseudogenes.org Pseudogenes for ZNF85 Gene

genes like me logo Genes that share paralogs with ZNF85: view

Variants for ZNF85 Gene

Sequence variations from dbSNP and Humsavar for ZNF85 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs1054688 -- 20,943,064(+) AGCCT(C/G)TTCAC intron-variant, utr-variant-3-prime, nc-transcript-variant
rs1063156 - 20,949,310(+) GCAAA(A/G)CTTTT reference, missense
rs2059139 -- 20,932,553(-) ccagc(C/T)ttccc intron-variant
rs2081049 -- 20,932,796(-) TTTTA(G/T)GCAAA intron-variant
rs2161459 -- 20,932,209(-) TCTTT(C/T)TCCTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF85 Gene

Variant ID Type Subtype PubMed ID
dgv3794n71 CNV Loss 21882294
nsv458377 CNV Gain 19166990
dgv201n21 CNV Loss 19592680
nsv509727 CNV Insertion 20534489
nsv2438 CNV Insertion 18451855

Relevant External Links for ZNF85 Gene

HapMap Linkage Disequilibrium report
ZNF85

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF85 Gene

Disorders for ZNF85 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for ZNF85 Gene including...

Search for ZNF85 Gene in MalaCards »

(2) University of Copenhagen DISEASES for ZNF85 Gene

(2) Novoseek inferred disease relationships for ZNF85 Gene

Disease -log(P) Hits PubMed IDs
thrombocytopenia 70.9 9
thrombosis 46.1 2
genes like me logo Genes that share disorders with ZNF85: view

No data available for UniProtKB/Swiss-Prot for ZNF85 Gene

Publications for ZNF85 Gene

  1. Functional analysis of ZNF85 KRAB zinc finger protein, a member of the highly homologous ZNF91 family. (PMID: 9839802) Poncelet D.A. … Martial J.A. (DNA Cell Biol. 1998) 3 4 23
  2. The evolutionarily conserved Kruppel-associated box domain defines a subfamily of eukaryotic multifingered proteins. (PMID: 2023909) Bellefroid E.J. … Martial J.A. (Proc. Natl. Acad. Sci. U.S.A. 1991) 3 4
  3. The human genome contains hundreds of genes coding for finger proteins of the Kruppel type. (PMID: 2505992) Bellefroid E.J. … Martial J.A. (DNA 1989) 2 3
  4. Clustered organization of homologous KRAB zinc-finger genes with enhanced expression in human T lymphoid cells. (PMID: 8467795) Bellefroid E.J. … Martial J.A. (EMBO J. 1993) 3
  5. Enhanced expression in seminoma of human zinc finger genes located on chromosome 19. (PMID: 9406578) Ogawa T. … Hosaka M. (Cancer Genet. Cytogenet. 1998) 3

Products for ZNF85 Gene

Sources for ZNF85 Gene

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