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Aliases for ZNF85 Gene

Aliases for ZNF85 Gene

  • Zinc Finger Protein 85 2 3 5
  • Zinc Finger Protein 85 (HPF4, HTF1) 2 3
  • Zinc Finger Protein HPF4 4
  • Zinc Finger Protein HTF1 4
  • HPF4 3
  • HTF1 3

External Ids for ZNF85 Gene

Previous GeneCards Identifiers for ZNF85 Gene

  • GC19P021544
  • GC19P021425
  • GC19P020882
  • GC19P020767
  • GC19P020897
  • GC19P021106
  • GC19P020597

Summaries for ZNF85 Gene

GeneCards Summary for ZNF85 Gene

ZNF85 (Zinc Finger Protein 85) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and transcription corepressor activity. An important paralog of this gene is ZNF681.

UniProtKB/Swiss-Prot for ZNF85 Gene

  • May be a transcriptional repressor.

Additional gene information for ZNF85 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF85 Gene

Genomics for ZNF85 Gene

GeneHancer (GH) Regulatory Elements for ZNF85 Gene

Promoters and enhancers for ZNF85 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I020922 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 550.8 +0.3 307 2.1 PKNOX1 RB1 ARID4B SIN3A ZNF48 ZBTB40 YY1 ZNF335 SCRT2 ZNF207 ZNF85 ZNF100 ZNF66 ZNF90 RPL7AP10 ZNF431 LOC641367 ZNF43 ZNF486 ENSG00000268416
GH19I020775 Promoter/Enhancer 1.4 Ensembl ENCODE 9.4 -146.7 -146703 1.8 PKNOX1 RB1 ARID4B KLF17 ZNF76 SIN3A KLF5 ZNF48 YY1 ZNF335 ZNF66 GC19M022334 ZNF100 ENSG00000267481 ZNF90 ZNF506 LOC641367 ZNF56 ZNF486 ZNF85
GH19I021600 Enhancer 1.4 Ensembl ENCODE dbSUPER 4.9 +679.8 679848 5.7 HDGF PKNOX1 ATF1 ARNT NCOA2 TCF12 ZNF766 E2F8 ATF7 CAVIN1 GC19P021601 ENSG00000268555 ZNF429 ZNF708 LOC105372321 ZNF85 LOC105372323 GC19P021614
GH19I021607 Enhancer 0.5 dbSUPER 5.1 +685.3 685275 2.2 SOX13 FOXA2 SP5 FOXA3 IKZF1 CEBPA SPI1 ENSG00000268555 ZNF708 ZNF85 GC19P021601 GC19P021614 LOC105372323
GH19I020970 Enhancer 0.2 FANTOM5 5.4 +47.2 47201 0.2 ENSG00000268326 ZNF85 GC19P020964
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF85 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF85 gene promoter:

Genomic Locations for ZNF85 Gene

Genomic Locations for ZNF85 Gene
chr19:20,923,221-20,950,697
(GRCh38/hg38)
Size:
27,477 bases
Orientation:
Plus strand
chr19:21,106,028-21,133,503
(GRCh37/hg19)

Genomic View for ZNF85 Gene

Genes around ZNF85 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF85 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF85 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF85 Gene

Proteins for ZNF85 Gene

  • Protein details for ZNF85 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q03923-ZNF85_HUMAN
    Recommended name:
    Zinc finger protein 85
    Protein Accession:
    Q03923
    Secondary Accessions:
    • B9ZVP4
    • Q6NVI0

    Protein attributes for ZNF85 Gene

    Size:
    595 amino acids
    Molecular mass:
    68736 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF85 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF85 Gene

Post-translational modifications for ZNF85 Gene

No Post-translational modifications

No data available for DME Specific Peptides for ZNF85 Gene

Domains & Families for ZNF85 Gene

Gene Families for ZNF85 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Suggested Antigen Peptide Sequences for ZNF85 Gene

Graphical View of Domain Structure for InterPro Entry

Q03923

UniProtKB/Swiss-Prot:

ZNF85_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF85: view

Function for ZNF85 Gene

Molecular function for ZNF85 Gene

GENATLAS Biochemistry:
zinc finger protein (HPF4,HTF1) KRAB subfamily,member of ZNF91 family,expressed in normal adult testis and in seminomas
UniProtKB/Swiss-Prot Function:
May be a transcriptional repressor.

Gene Ontology (GO) - Molecular Function for ZNF85 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA,TAS --
GO:0003700 DNA binding transcription factor activity TAS 9839802
GO:0003714 transcription corepressor activity TAS 9839802
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF85: view
genes like me logo Genes that share phenotypes with ZNF85: view

miRNA for ZNF85 Gene

miRTarBase miRNAs that target ZNF85

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF85 Gene

Localization for ZNF85 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF85 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF85 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF85 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus TAS,IDA --
genes like me logo Genes that share ontologies with ZNF85: view

Pathways & Interactions for ZNF85 Gene

SuperPathways for ZNF85 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF85 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:1903507 negative regulation of nucleic acid-templated transcription IEA --
genes like me logo Genes that share ontologies with ZNF85: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF85 Gene

Drugs & Compounds for ZNF85 Gene

(1) Drugs for ZNF85 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with ZNF85: view

Transcripts for ZNF85 Gene

Unigene Clusters for ZNF85 Gene

Zinc finger protein 85:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF85 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d
SP1: - -
SP2: - - - - - -
SP3: -
SP4: - -
SP5: - - - - - - -
SP6: - - - -

Relevant External Links for ZNF85 Gene

GeneLoc Exon Structure for
ZNF85
ECgene alternative splicing isoforms for
ZNF85

Expression for ZNF85 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF85 Gene

mRNA differential expression in normal tissues according to GTEx for ZNF85 Gene

This gene is overexpressed in Testis (x6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF85 Gene



NURSA nuclear receptor signaling pathways regulating expression of ZNF85 Gene:

ZNF85

SOURCE GeneReport for Unigene cluster for ZNF85 Gene:

Hs.37138

mRNA Expression by UniProt/SwissProt for ZNF85 Gene:

Q03923-ZNF85_HUMAN
Tissue specificity: Widely expressed, including in testis.

Evidence on tissue expression from TISSUES for ZNF85 Gene

  • Lung(4.2)
genes like me logo Genes that share expression patterns with ZNF85: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF85 Gene

Orthologs for ZNF85 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF85 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF85 33 34
  • 99.09 (n)
cow
(Bos Taurus)
Mammalia -- 34
  • 58 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Zfp493 34
  • 58 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 52 (a)
ManyToMany
-- 34
  • 43 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 34
  • 42 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 54 (a)
ManyToMany
-- 34
  • 46 (a)
ManyToMany
-- 34
  • 41 (a)
ManyToMany
-- 34
  • 39 (a)
ManyToMany
-- 34
  • 36 (a)
ManyToMany
-- 34
  • 36 (a)
ManyToMany
-- 34
  • 35 (a)
ManyToMany
-- 34
  • 30 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii wufc22b08 33
fruit fly
(Drosophila melanogaster)
Insecta bowl 35
  • 46 (a)
sob 35
  • 46 (a)
CG18764 35
  • 43 (a)
CG10147 35
  • 36 (a)
EG:95B7.7 35
  • 32 (a)
CG7386 35
  • 30 (a)
Species where no ortholog for ZNF85 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF85 Gene

ENSEMBL:
Gene Tree for ZNF85 (if available)
TreeFam:
Gene Tree for ZNF85 (if available)

Paralogs for ZNF85 Gene

genes like me logo Genes that share paralogs with ZNF85: view

Variants for ZNF85 Gene

Sequence variations from dbSNP and Humsavar for ZNF85 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000023550 -- 20,945,251(+) G/A genic_downstream_transcript_variant, intron_variant
rs1000178116 -- 20,942,900(+) C/T 3_prime_UTR_variant, intron_variant, non_coding_transcript_variant
rs1000195288 -- 20,940,198(+) T/G intron_variant
rs1000230490 -- 20,922,122(+) C/G upstream_transcript_variant
rs1000337557 -- 20,928,564(+) G/A/C genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF85 Gene

Variant ID Type Subtype PubMed ID
dgv201n21 CNV loss 19592680
dgv3470n100 CNV gain 25217958
esv2763043 CNV gain 21179565
esv3583298 CNV loss 25503493
esv3583299 CNV loss 25503493
nsv1055738 CNV gain 25217958
nsv1058430 CNV loss 25217958
nsv1063954 CNV gain 25217958
nsv1066170 CNV loss 25217958
nsv1067455 CNV gain 25217958
nsv1138680 CNV deletion 24896259
nsv2438 CNV insertion 18451855
nsv458377 CNV gain 19166990
nsv509727 CNV insertion 20534489
nsv578809 CNV gain 21841781
nsv578946 CNV loss 21841781
nsv578947 CNV loss 21841781
nsv960809 CNV duplication 23825009

Variation tolerance for ZNF85 Gene

Residual Variation Intolerance Score: 97.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.95; 59.76% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF85 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF85

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF85 Gene

Disorders for ZNF85 Gene

Additional Disease Information for ZNF85

No disorders were found for ZNF85 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF85 Gene

Publications for ZNF85 Gene

  1. Functional analysis of ZNF85 KRAB zinc finger protein, a member of the highly homologous ZNF91 family. (PMID: 9839802) Poncelet DA … Martial JA (DNA and cell biology 1998) 3 4 22 58
  2. The evolutionarily conserved Krüppel-associated box domain defines a subfamily of eukaryotic multifingered proteins. (PMID: 2023909) Bellefroid EJ … Martial JA (Proceedings of the National Academy of Sciences of the United States of America 1991) 3 4 58
  3. The human genome contains hundreds of genes coding for finger proteins of the Krüppel type. (PMID: 2505992) Bellefroid EJ … Martial JA (DNA (Mary Ann Liebert, Inc.) 1989) 2 3 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58

Products for ZNF85 Gene

Sources for ZNF85 Gene

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