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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZNF85 Gene

protein-coding   GIFtS: 50
GCID: GC19P021106

Zinc Finger Protein 85

(Previous names: zinc finger protein 85 (HPF4, HTF1))
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Zinc Finger Protein 851 2
Zinc Finger Protein 85 (HPF4, HTF1)1 2
HPF42
HTF12
Zinc Finger Protein HPF43
Zinc Finger Protein HTF13

External Ids:    HGNC: 131601   Entrez Gene: 76392   Ensembl: ENSG000001057507   OMIM: 6038995   UniProtKB: Q039233   

Export aliases for ZNF85 gene to outside databases

Previous GC identifers: GC19P021544 GC19P021425 GC19P020882 GC19P020767 GC19P020897 GC19P020597


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ZNF85 Gene: 
ZNF85 (zinc finger protein 85) is a protein-coding gene. Diseases associated with ZNF85 include testis seminoma, and heparin-induced thrombocytopenia. GO annotations related to this gene include transcription corepressor activity and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ZNF486.

UniProtKB/Swiss-Prot: ZNF85_HUMAN, Q03923
Function: May be a transcriptional repressor




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.2  NT_011295.11  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZNF85 gene promoter:
         NF-YB   CBF-B   CBF-A   NF-YA   CP1A   NF-Y   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF85 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZNF85

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF85


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p12   Ensembl cytogenetic band:  19p12   HGNC cytogenetic band: 19p12

ZNF85 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF85 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P021106:  view genomic region     (about GC identifiers)

Start:
21,106,028 bp from pter      End:
21,133,503 bp from pter
Size:
27,476 bases      Orientation:
plus strand

1 alternative location:
Chr19+,NW_003315962 266,529-293,973     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZNF85_HUMAN, Q03923 (See protein sequence)
Recommended Name: Zinc finger protein 85  
Size: 595 amino acids; 68736 Da
Subcellular location: Nucleus
Secondary accessions: B9ZVP4 Q6NVI0
Alternative splicing: 3 isoforms:  Q03923-1   Q03923-2   Q03923-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ZNF85: NX_Q03923

Explore proteomics data for ZNF85 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q03923

  • ZNF85 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ZNF85 Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_001243100.1  NP_001243101.1  NP_001243102.1  NP_003420.2  

    ENSEMBL proteins: 
     ENSP00000471467   ENSP00000471286   ENSP00000300540   ENSP00000469243   ENSP00000470347  
     ENSP00000329793   ENSP00000470667   ENSP00000469496   ENSP00000342340   ENSP00000471588  
     ENSP00000472145   ENSP00000473059   ENSP00000469673   ENSP00000472206  

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    Cloud-Clone Corp. Proteins for ZNF85 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--

    ZNF85 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR001909 Krueppel-associated_box
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q03923

    ProtoNet protein and cluster: Q03923

    2 Blocks protein domains:
    IPB001909 KRAB box
    IPB007086 C2H2-type zinc finger signature


    UniProtKB/Swiss-Prot: ZNF85_HUMAN, Q03923
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 16 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    ZNF85 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZNF85_HUMAN, Q03923
    Function: May be a transcriptional repressor

         Genatlas biochemistry entry for ZNF85:
    zinc finger protein (HPF4,HTF1) KRAB subfamily,member of ZNF91 family,expressed in normal adult testis and in
    seminomas

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity TAS9839802
    GO:0003714transcription corepressor activity TAS9839802
    GO:0008270zinc ion binding ----
         
    ZNF85 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ZNF85:
     Increased G2M DNA content 

    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF85

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent ----

    ZNF85 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ZNF85 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZNF85

    1 Novoseek inferred chemical compound relationship for ZNF85 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    heparin 66.7 29 10848821 (3), 11342462 (2), 8695787 (2), 19452409 (2) (see all 9)

    Search CenterWatch for drugs/clinical trials and news about ZNF85

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZNF85 gene (4 alternative transcripts): 
    NM_001256171.1  NM_001256172.1  NM_001256173.1  NM_003429.4  

    Unigene Cluster for ZNF85:

    Zinc finger protein 85
    Hs.37138  [show with all ESTs]
    Unigene Representative Sequence: BC036394
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000597314 ENST00000601924 ENST00000300540(uc002npf.3 uc002nph.1)
    ENST00000595854 ENST00000601284 ENST00000328178(uc002npg.4 uc010ecn.3 uc010eco.3 uc002npi.3)
    ENST00000599885 ENST00000596476 ENST00000345030 ENST00000599064 ENST00000596534
    ENST00000598862 ENST00000595742 ENST00000601023
    miRNA
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    Inhib. RNA
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    Additional mRNA sequence: 

    AK308258.1 BC008688.1 BC036394.1 BC047646.1 BC068066.1 D70831.1 M61866.1 M61868.1 
    NR_045830.1 U35376.1 

    13 DOTS entries:

    DT.92431200  DT.92044530  DT.100702930  DT.92414322  DT.100000539  DT.121496517  DT.87004303  DT.87014749 
    DT.95368438  DT.121496408  DT.121496445  DT.121496672  DT.95114454 

    24/35 AceView cDNA sequences (see all 35):

    BC047646 BG030684 BC068066 H94743 BM788849 AA778551 BU680760 BI560594 
    BX344988 BQ010634 CA418053 AI253261 BG721813 BX356542 BF699661 BM801965 
    W02127 BU620315 BU147159 BX356543 M61868 CA442806 BG718610 AA337346 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF85 (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d
    SP1:                    -     -                                                   
    SP2:                    -     -     -     -     -     -                           
    SP3:                                -                                             
    SP4:                                -     -                                       
    SP5:              -     -     -     -     -     -     -                           


    ECgene alternative splicing isoforms for ZNF85

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZNF85 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGAAGAATGT
    ZNF85 Expression
    About this image


    See ZNF85 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZNF85

    SOURCE GeneReport for Unigene cluster: Hs.37138

    UniProtKB/Swiss-Prot: ZNF85_HUMAN, Q03923
    Tissue specificity: Widely expressed, including in testis

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for ZNF85 gene from 2/6 species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    29(a)
    1 → many
    GL343733.1(125230-159240)
    zebrafish
    (Danio rerio)
    Actinopterygii wufc22b082 wufc22b08 73.15(n)   324228  57044031 
            Species with no ortholog for ZNF85

    ENSEMBL Gene Tree for ZNF85 (if available)
    TreeFam Gene Tree for ZNF85 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZNF85 gene
    ZNF4862  ZNF1952  ZNF7272  ZNF922  ZNF1002  ZNF7322  ZNF6752  ZNF1382  
    ZNF5062  ZNF662  ZNF2732  ZNF6952  ZNF6262  ZNF6802  ZNF4792  ZNF2532  
    ZNF6822  ZNF4922  ZNF6762  ZNF6812  ZNF1412  ZNF7362  ZNF6792  ZNF2572  
    ZNF2672  ZNF2542  ZNF7372  ZNF982  ZNF7162  ZNF7142  ZNF5192  ZNF4302  
    ZNF7302  ZNF7082  ZNF1172  ZNF4312  ZNF902  ZNF7262  ZNF7282  
    18/598 SIMAP similar genes for ZNF85 using alignment to 12 protein entries:     ZNF85_HUMAN (see all proteins) (see all similar genes):
    ZFS-1    OK/SW-cl.41    ARL6IP5    C12orf76    X-linked retinopathy protein    FP6651
    pp12301    LINC00269    TUBA1C    ZNF818P    C3orf64    MGC12518
    ADCK1    EEF1E1    LOC100996426    SEC14L3    ZNF138    ZNF506

    ZNF85 for paralogs           About GeneDecksing


    4 Pseudogenes.org Pseudogenes for ZNF85
    PGOHUM00000234554 PGOHUM00000250598 PGOHUM00000234640 PGOHUM00000232727


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/948 SNPs in ZNF85 are shown (see all 948)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs561957181,2
    C--21051758(+) TGTGT-/GTGT  
            
    ATGTG
    5 -- int11Minor allele frequency- GTGT:0.00NA 2
    rs1476592431,2
    C--21104146(+) GAACCC/TAGGAG 5 -- us2k10--------
    rs1917398841,2
    --21104174(+) CAGAGA/GTCGCA 5 -- us2k10--------
    rs1451659201,2
    --21104177(+) AGATCA/GCACCA 5 -- us2k10--------
    rs1468392541,2
    C--21104201(+) TGGGCA/GACAGA 5 -- us2k10--------
    rs1406741371,2
    --21104216(+) GACTCC/TGTCTC 5 -- us2k10--------
    rs81044851,2
    C,F,A,H--21104446(+) gcattT/Gcaatt 5 -- us2k121Minor allele frequency- G:0.35NS EA NA WA 2348
    rs730034911,2
    C,F--21104478(+) GGTTCA/GTTATG 5 -- us2k14Minor allele frequency- G:0.12CSA WA NA 242
    rs1839843621,2
    --21104560(+) GTTACC/TTTCTA 5 -- us2k10--------
    rs775953011,2
    C,F--21104580(+) ACCATA/GAAAGT 5 -- us2k11Minor allele frequency- G:0.03NA 120

    HapMap Linkage Disequilibrium report for ZNF85 (21106028 - 21133503 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for ZNF85:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv2438CNV Insertion18451855
    nsv509727CNV Insertion20534489
    dgv3794n71CNV Loss21882294
    dgv201n21CNV Loss19592680
    nsv458377CNV Gain19166990

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 603899    OMIM disorders: --

    6 diseases for ZNF85:    About MalaCards
    testis seminoma    heparin-induced thrombocytopenia    seminoma    thrombocytopenia
    thrombosis    gastric cancer

    2 diseases from the University of Copenhagen DISEASES database for ZNF85:
    Thrombocytopenia     Anteroseptal myocardial infarction

    ZNF85 for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for ZNF85 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    thrombocytopenia 70.9 11 8695787 (2), 9930558 (1), 10848821 (1), 9238439 (1) (see all 8)
    thrombosis 46.1 2 11342462 (1), 8695787 (1)


    Export disorders for ZNF85 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZNF85 gene, integrated from 9 sources (see all 23):
    (articles sorted by number of sources associating them with ZNF85)
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    world of online information

    1. Functional analysis of ZNF85 KRAB zinc finger protein, a member of the highly homologous ZNF91 family. (PubMed id 9839802)1, 2, 9 Poncelet D.A.... Martial J.A. (1998)
    2. The evolutionarily conserved Kruppel-associated box domain defines a subfamily of eukaryotic multifingered proteins. (PubMed id 2023909)1, 2 Bellefroid E.J....Martial J.A. (1991)
    3. The human genome contains hundreds of genes coding for finger proteins of the Kruppel type. (PubMed id 2505992)1, 3 Bellefroid E.J....Martial J.A. (1989)
    4. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    6. Transcriptome analysis of human gastric cancer. (PubMed id 16341674)1 Oh J.H....Kim N.S. (2005)
    7. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PubMed id 15342556)1 Suzuki Y.... Sugano S. (2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    9. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (2004)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7639 HGNC: 13160 AceView: ZNF85 Ensembl:ENSG00000105750 euGenes: HUgn7639
    ECgene: ZNF85 H-InvDB: ZNF85

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZNF85 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZNF85 gene:
    Search GeneIP for patents involving ZNF85

    GeneCards and IP:
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