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ZNF846 Gene

protein-coding   GIFtS: 38
GCID: GC19M009868

Zinc Finger Protein 846

  Search for ZNF846
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger Protein 8461 2

External Ids:    HGNC: 272601   Entrez Gene: 1629932   Ensembl: ENSG000001966057   UniProtKB: Q147U13   

Export aliases for ZNF846 gene to outside databases

Previous GC identifers: GC19M009730 GC19M009449


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZNF846 Gene:
ZNF846 (zinc finger protein 846) is a protein-coding gene. An important paralog of this gene is ZNF812.

UniProtKB/Swiss-Prot: ZN846_HUMAN, Q147U1
Function: May be involved in transcriptional regulation (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NT_011295.12  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZNF846 gene promoter:
         p53   HTF   Pax-6   XBP-1   HNF-1A   C/EBPalpha   CREB   deltaCREB   HNF-1   POU2F1c   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for ZNF846

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF846


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.2   Ensembl cytogenetic band:  19p13.2   HGNC cytogenetic band: 19p13.2

ZNF846 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF846 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M009868:  view genomic region     (about GC identifiers)

Start:
9,862,669 bp from pter      End:
9,903,856 bp from pter
Size:
41,188 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ZN846_HUMAN, Q147U1 (See protein sequence)
Recommended Name: Zinc finger protein 846  
Size: 533 amino acids; 60552 Da
Secondary accessions: A8K0H1 B3KUP1
Alternative splicing: 2 isoforms:  Q147U1-1   Q147U1-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ZNF846: NX_Q147U1

Explore proteomics data for ZNF846 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ZNF846 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001071092.1  
    ENSEMBL proteins: 
     ENSP00000467021   ENSP00000465467   ENSP00000467891   ENSP00000466236   ENSP00000380999  
     ENSP00000466547   ENSP00000466599   ENSP00000466175  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR001909 Krueppel-associated_box
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q147U1

    ProtoNet protein and cluster: Q147U1

    UniProtKB/Swiss-Prot: ZN846_HUMAN, Q147U1
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 14 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    ZNF846 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN846_HUMAN, Q147U1
    Function: May be involved in transcriptional regulation (By similarity)

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0046872metal ion binding IEA--
         
    ZNF846 for ontologies           About GeneDecksing


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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZN846_HUMAN, Q147U1: Nucleus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--

    ZNF846 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF846
    Interactions:

        Search GeneGlobe Interaction Network for ZNF846

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--

    ZNF846 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for ZNF846 (ZN846)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ZNF846 gene: 
    NM_001077624.1  

    Unigene Cluster for ZNF846:

    Zinc finger protein 846
    Hs.665717  [show with all ESTs]
    Unigene Representative Sequence: NM_001077624
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000589453 ENST00000588267 ENST00000592859 ENST00000586293 ENST00000397902(uc021uoq.1 uc010dww.3 uc002mmb.1 uc002mmc.1)
    ENST00000591377 ENST00000589412 ENST00000586814 ENST00000592587 ENST00000587650
    ENST00000590471 ENST00000589038
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    Additional mRNA sequence: 

    AK097652.1 AK289536.1 AK308938.1 BC037359.1 BC118576.1 BC118657.1 

    4 DOTS entries:

    DT.101976553  DT.75199827  DT.92417633  DT.40125831 

    Selected AceView cDNA sequences (see all 29):

    AW206489 AK097652 AI253579 BE644878 AW197386 AA825470 BE467522 AI648518 
    CA307779 BC037359 BG259867 BE218035 AI912686 AI149813 AI299487 BX099894 
    AW119131 AW140126 BG761308 BU075959 AI028737 AI936565 AI376632 AI928161 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZNF846 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGAAAAAACC
    ZNF846 Expression
    About this image

    ZNF846 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZNF846 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.665717
        Custom PCR Arrays for ZNF846
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for ZNF846 gene from Selected species (see all 4)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfp8461 , 5 zinc finger protein 8461, 5 64.77(n)1
    53.62(a)1
      9 (7.58 cM)5
    2447211  NM_172919.21  NP_766507.21 
     205813255 


    ENSEMBL Gene Tree for ZNF846 (if available)
    TreeFam Gene Tree for ZNF846 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZNF846 gene
    ZNF8122  ZNF7782  ZNF2662  ZNF4262  ZNF5602  ZNF1212  ZNF5612  ZNF5592  
    ZNF5622  
    Selected SIMAP similar genes for ZNF846 using alignment to 5 protein entries:     ZN846_HUMAN (see all proteins) (see all similar genes):
    ZNF559    ZNF124    ZNF649    ZNF776    ZNF420    ZNF556
    ZNF177    ZNF519    ZNF571    ZNF789    ZNF625    ZNF317
    ZNF283    ZNF229    ZNF738    ZNF439    ZNF415    ZFS-4

    ZNF846 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZNF846 (see all 338)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1114718431,2
    C,F--9867668(+) AGATCG/AAGACC 1 -- ds50011Minor allele frequency- A:0.50NA 2
    rs1998005531,2
    C--9867708(+) CTACT-/AAAAAT 1 -- ds50010--------
    rs1460121171,2
    C--9867748(+) TGCCCA/GTAGTC 1 -- ds50010--------
    rs1129051671,2
    C,F--9867795(+) GAACCC/TAGGAG 1 -- ds50011Minor allele frequency- T:0.50NA 2
    rs1926821171,2
    --9867818(+) GTGGGA/CCAAGG 1 -- ds50010--------
    rs1835849191,2
    --9867913(+) CAAAGA/GCTTTA 1 -- ds50010--------
    rs1882767191,2
    --9867916(+) AGGCTA/TTACCA 1 -- ds50010--------
    rs1812082421,2
    --9867960(+) GAGTTC/TTTACA 1 -- ds50010--------
    rs1847912681,2
    --9867981(+) TGTGAA/CGAATT 1 -- ds50010--------
    rs1896503261,2
    --9868013(+) TATCAC/TTGGGA 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for ZNF846 (9862669 - 9903856 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for ZNF846:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2675791CNV Deletion23128226
    nsv2413CNV Loss18451855
    nsv518826CNV Loss19592680
    nsv498892CNV Loss21111241
    esv22853CNV Loss19812545
    nsv514908CNV Loss21397061

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZNF846 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with ZNF846)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    2. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    3. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (Cell 2010)
    4. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    5. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (Nature 2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 162993 HGNC: 27260 AceView: LOC162993 Ensembl:ENSG00000196605 euGenes: HUgn162993
    ECgene: ZNF846 H-InvDB: ZNF846

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZNF846 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZNF846 gene:
    Search GeneIP for patents involving ZNF846

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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