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Aliases for ZNF846 Gene

Aliases for ZNF846 Gene

  • Zinc Finger Protein 846 2 3 5

External Ids for ZNF846 Gene

Previous GeneCards Identifiers for ZNF846 Gene

  • GC19M009868
  • GC19M009449

Summaries for ZNF846 Gene

GeneCards Summary for ZNF846 Gene

ZNF846 (Zinc Finger Protein 846) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF778.

UniProtKB/Swiss-Prot for ZNF846 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF846 Gene

Genomics for ZNF846 Gene

Regulatory Elements for ZNF846 Gene

Enhancers for ZNF846 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F009674 0.7 ENCODE 21 +118.4 118407 2.1 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A DMAP1 YY1 CBX5 ZNF143 ZNF561 ZNF558 FBXL12 ZNF699 ZNF846 ENSG00000269300 ZNF559 EIF3G MIR1181 LOC100419831
GH19F009620 1 FANTOM5 ENCODE 20.9 +171.3 171290 3.1 PKNOX1 ARNT CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF143 ZNF561 ZNF558 FBXL12 EIF3G ENSG00000269300 ZNF699 ZNF846 LOC100128428 MIR1181 LOC100419831
GH19F009667 0.3 FANTOM5 14.3 +126.3 126344 0.3 ZNF846 ZNF559 ZNF177 PIR46077 ZNF562
GH19F009666 0.7 FANTOM5 14 +127.0 126967 0.4 ZNF846 ZNF559 ZNF559-ZNF177 OR7D4 ZNF121 ZNF426 OLFM2 ZNF177 PIR46077 ZNF562
GH19F009638 0.7 FANTOM5 13.1 +154.8 154829 0.3 ZNF561 OR7D4 ZNF846 ZNF177 OR7E24 OLFM2 ZNF559 ZNF562 ZNF426 ZNF559-ZNF177
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ZNF846 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF846 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000343166 780 2401 HDAC1 CBX3 PKNOX1 ZNF48 EGR1 CREM EGR2 ZNF263 SP3 ZBTB2

Genomic Location for ZNF846 Gene

Chromosome:
19
Start:
9,751,993 bp from pter
End:
9,793,180 bp from pter
Size:
41,188 bases
Orientation:
Minus strand

Genomic View for ZNF846 Gene

Genes around ZNF846 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF846 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF846 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF846 Gene

Proteins for ZNF846 Gene

  • Protein details for ZNF846 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q147U1-ZN846_HUMAN
    Recommended name:
    Zinc finger protein 846
    Protein Accession:
    Q147U1
    Secondary Accessions:
    • A8K0H1
    • B3KUP1

    Protein attributes for ZNF846 Gene

    Size:
    533 amino acids
    Molecular mass:
    60552 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF846 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF846 Gene

Post-translational modifications for ZNF846 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF846 Gene

Domains & Families for ZNF846 Gene

Gene Families for ZNF846 Gene

Protein Domains for ZNF846 Gene

Suggested Antigen Peptide Sequences for ZNF846 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q147U1

UniProtKB/Swiss-Prot:

ZN846_HUMAN :
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 14 C2H2-type zinc fingers.
Domain:
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 14 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF846: view

Function for ZNF846 Gene

Molecular function for ZNF846 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF846 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF846: view
genes like me logo Genes that share phenotypes with ZNF846: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF846 Gene

Localization for ZNF846 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF846 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF846 Gene COMPARTMENTS Subcellular localization image for ZNF846 gene
Compartment Confidence
nucleus 5
cytoskeleton 2
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF846 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF846: view

Pathways & Interactions for ZNF846 Gene

SuperPathways for ZNF846 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF846 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF846: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF846 Gene

Transcripts for ZNF846 Gene

Unigene Clusters for ZNF846 Gene

Zinc finger protein 846:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF846 Gene

No ASD Table

Relevant External Links for ZNF846 Gene

GeneLoc Exon Structure for
ZNF846
ECgene alternative splicing isoforms for
ZNF846

Expression for ZNF846 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF846 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF846 Gene



Protein tissue co-expression partners for ZNF846 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF846 Gene:

ZNF846

SOURCE GeneReport for Unigene cluster for ZNF846 Gene:

Hs.665717
genes like me logo Genes that share expression patterns with ZNF846: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF846 Gene

Orthologs for ZNF846 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF846 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF846 34 35
  • 99.44 (n)
dog
(Canis familiaris)
Mammalia ZNF846 34
  • 78.18 (n)
mouse
(Mus musculus)
Mammalia Zfp846 34 16
  • 64.77 (n)
rat
(Rattus norvegicus)
Mammalia Zfp846 34
  • 64.77 (n)
Species where no ortholog for ZNF846 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF846 Gene

ENSEMBL:
Gene Tree for ZNF846 (if available)
TreeFam:
Gene Tree for ZNF846 (if available)

Paralogs for ZNF846 Gene

Paralogs for ZNF846 Gene

(506) SIMAP similar genes for ZNF846 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ZNF846: view

Variants for ZNF846 Gene

Sequence variations from dbSNP and Humsavar for ZNF846 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1007550 -- 9,768,596(-) CTGCT(A/G)GGTCT intron-variant, nc-transcript-variant, utr-variant-5-prime
rs10401153 -- 9,751,122(+) tgagg(C/G)cttgt nc-transcript-variant, utr-variant-3-prime
rs10406293 -- 9,784,943(+) gcaga(A/C)gaatt intron-variant
rs10408073 -- 9,756,837(+) TTGTG(A/G)AGTAT intron-variant, nc-transcript-variant, downstream-variant-500B, utr-variant-3-prime
rs10410628 -- 9,752,345(+) gctca(C/T)gtcca nc-transcript-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ZNF846 Gene

Variant ID Type Subtype PubMed ID
esv22853 CNV loss 19812545
esv2675791 CNV deletion 23128226
esv3643641 CNV loss 21293372
nsv2413 CNV deletion 18451855
nsv478334 CNV novel sequence insertion 20440878
nsv498892 CNV loss 21111241
nsv514908 CNV loss 21397061
nsv518826 CNV loss 19592680

Variation tolerance for ZNF846 Gene

Residual Variation Intolerance Score: 85.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.76; 78.93% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF846 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF846

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF846 Gene

Disorders for ZNF846 Gene

Relevant External Links for ZNF846

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF846

No disorders were found for ZNF846 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF846 Gene

Publications for ZNF846 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64
  3. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PMID: 21145461) Bennett E.J. … Harper J.W. (Cell 2010) 3 64
  4. A quantitative atlas of mitotic phosphorylation. (PMID: 18669648) Dephoure N. … Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2008) 4 64
  5. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 4 64

Products for ZNF846 Gene

Sources for ZNF846 Gene

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