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Aliases for ZNF84 Gene

Aliases for ZNF84 Gene

  • Zinc Finger Protein 84 2 3 5
  • Zinc Finger Protein HPF2 3 4
  • Zinc Finger Protein 84 (HPF2) 2
  • HPF2 3

External Ids for ZNF84 Gene

Previous GeneCards Identifiers for ZNF84 Gene

  • GC12P131135
  • GC12P133187
  • GC12P131801
  • GC12P131390
  • GC12P132224
  • GC12P132124
  • GC12P133613

Summaries for ZNF84 Gene

GeneCards Summary for ZNF84 Gene

ZNF84 (Zinc Finger Protein 84) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF268.

UniProtKB/Swiss-Prot for ZNF84 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF84 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF84 Gene

Genomics for ZNF84 Gene

GeneHancer (GH) Regulatory Elements for ZNF84 Gene

Promoters and enhancers for ZNF84 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12I133036 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.8 +0.2 215 2.2 CLOCK MLX ARID4B SIN3A DMAP1 SLC30A9 POLR2B ZNF766 ZNF207 ZNF143 LOC101928597 ZNF84 ZNF140 ZNF26 ZNF268 GOLGA3 ZNF891 ZNF10 EP400P1 ENSG00000279466
GH12I133038 Promoter 0.5 EPDnew 550.8 +1.7 1709 0.1 LOC101928597 ZNF84 ENSG00000279466
GH12I132597 Enhancer 1.2 Ensembl ENCODE 164.3 -439.0 -438972 1.8 HDGF ARNT YBX1 ZNF2 ZNF143 ZNF548 SP3 ZNF662 REST ZNF592 ZNF140 EP400 ZNF84 ZNF268 ZNF891 ZNF26 GOLGA3 ZNF605 ANKLE2 DDX51
GH12I133129 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 44.3 +93.2 93215 2.6 PKNOX1 CLOCK ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 SLC30A9 ZNF891 ZNF10 ENSG00000256825 ZNF84 DDX51 ZNF605 ZNF268 ZNF140 CHFR ENSG00000250790
GH12I132954 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 36.1 -81.4 -81421 2.7 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 ETS1 ZNF280A ZNF766 GLIS2 CHFR ZNF605 ZNF84 ZNF268 ZNF140 ZNF10 ZNF891 ENSG00000250790 ZNF26 EP400P1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF84 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF84 gene promoter:

Genomic Locations for ZNF84 Gene

Genomic Locations for ZNF84 Gene
chr12:133,037,286-133,063,304
(GRCh38/hg38)
Size:
26,019 bases
Orientation:
Plus strand
chr12:133,613,878-133,639,885
(GRCh37/hg19)

Genomic View for ZNF84 Gene

Genes around ZNF84 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF84 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF84 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF84 Gene

Proteins for ZNF84 Gene

  • Protein details for ZNF84 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P51523-ZNF84_HUMAN
    Recommended name:
    Zinc finger protein 84
    Protein Accession:
    P51523
    Secondary Accessions:
    • B2RAK5
    • D3DXJ1
    • Q3ZCV9
    • Q5D057
    • Q86XU8
    • Q9NNX7
    • Q9UC17
    • Q9UC18

    Protein attributes for ZNF84 Gene

    Size:
    738 amino acids
    Molecular mass:
    85457 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF84 Gene

Post-translational modifications for ZNF84 Gene

No Post-translational modifications

No data available for DME Specific Peptides for ZNF84 Gene

Domains & Families for ZNF84 Gene

Gene Families for ZNF84 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Suggested Antigen Peptide Sequences for ZNF84 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P51523

UniProtKB/Swiss-Prot:

ZNF84_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF84: view

Function for ZNF84 Gene

Molecular function for ZNF84 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF84 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding NAS 2505992
GO:0008270 zinc ion binding NAS 2505992
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF84: view
genes like me logo Genes that share phenotypes with ZNF84: view

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF84 Gene

Localization for ZNF84 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF84 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF84 gene
Compartment Confidence
nucleus 3

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF84 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF84: view

Pathways & Interactions for ZNF84 Gene

SuperPathways for ZNF84 Gene

No Data Available

Interacting Proteins for ZNF84 Gene

Gene Ontology (GO) - Biological Process for ZNF84 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF84: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF84 Gene

Drugs & Compounds for ZNF84 Gene

No Compound Related Data Available

Transcripts for ZNF84 Gene

Unigene Clusters for ZNF84 Gene

Zinc finger protein 84:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF84 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b · 5c · 5d · 5e ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c · 8d · 8e ^ 9
SP1: - - - - - - -
SP2: - - - - - - - - -
SP3: - - - - - - - -
SP4: - - - - - - - - - -
SP5: - - - - - - - - - - - - -
SP6: - - - - - - -
SP7: - - - - -
SP8: - - - - - -
SP9: - - - - -
SP10: - - - - -
SP11: - -
SP12: - -
SP13:

Relevant External Links for ZNF84 Gene

GeneLoc Exon Structure for
ZNF84
ECgene alternative splicing isoforms for
ZNF84

Expression for ZNF84 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF84 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF84 Gene:

ZNF84

SOURCE GeneReport for Unigene cluster for ZNF84 Gene:

Hs.445019

Evidence on tissue expression from TISSUES for ZNF84 Gene

  • Nervous system(4.7)
  • Lung(4.2)
genes like me logo Genes that share expression patterns with ZNF84: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF84 Gene

Orthologs for ZNF84 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF84 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF84 33 34
  • 99.64 (n)
cow
(Bos Taurus)
Mammalia ZNF84 33
  • 89.57 (n)
-- 34
  • 83 (a)
OneToMany
dog
(Canis familiaris)
Mammalia ZNF26 33
  • 88.89 (n)
-- 34
  • 83 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG14711 35
  • 50 (a)
Kr 35
  • 49 (a)
CG3485 35
  • 44 (a)
crol 35
  • 43 (a)
CG15436 35
  • 42 (a)
CG5245 35
  • 41 (a)
CG12299 35
  • 40 (a)
CG18555 35
  • 40 (a)
CG11762 35
  • 39 (a)
BG:DS02740.8 35
  • 37 (a)
CG11247 35
  • 37 (a)
CG8319 35
  • 37 (a)
Neu2 35
  • 36 (a)
CG10543 35
  • 33 (a)
CG7987 35
  • 31 (a)
CG8301 35
  • 31 (a)
CG18476 35
  • 30 (a)
CG18011 35
  • 25 (a)
worm
(Caenorhabditis elegans)
Secernentea M03D4.4 35
  • 32 (a)
Species where no ortholog for ZNF84 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for ZNF84 Gene

ENSEMBL:
Gene Tree for ZNF84 (if available)
TreeFam:
Gene Tree for ZNF84 (if available)

Paralogs for ZNF84 Gene

(562) SIMAP similar genes for ZNF84 Gene using alignment to 9 proteins:

Pseudogenes.org Pseudogenes for ZNF84 Gene

genes like me logo Genes that share paralogs with ZNF84: view

Variants for ZNF84 Gene

Sequence variations from dbSNP and Humsavar for ZNF84 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000003753 -- 133,056,299(+) G/C intron_variant
rs1000338308 -- 133,062,934(+) A/G 3_prime_UTR_variant
rs1000515326 -- 133,050,876(+) A/C intron_variant
rs1000687647 -- 133,044,838(+) T/C intron_variant
rs1000737825 -- 133,044,698(+) G/A/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF84 Gene

Variant ID Type Subtype PubMed ID
dgv1590n100 CNV gain 25217958
dgv1592n100 CNV gain 25217958
dgv1593n100 CNV gain 25217958
dgv330e199 CNV deletion 23128226
dgv917n106 CNV deletion 24896259
esv27162 CNV gain+loss 19812545
esv2759923 CNV loss 17122850
esv3631326 CNV loss 21293372
esv3631327 CNV gain 21293372
nsv1048027 CNV gain 25217958
nsv1054933 CNV gain 25217958
nsv1071081 CNV deletion 25765185
nsv525745 CNV gain 19592680
nsv9048 CNV gain 18304495
nsv9049 CNV gain 18304495

Additional Variant Information for ZNF84 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF84

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for ZNF84 Gene

Disorders for ZNF84 Gene

Additional Disease Information for ZNF84

No disorders were found for ZNF84 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF84 Gene

Publications for ZNF84 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Members of the zinc finger protein gene family sharing a conserved N-terminal module. (PMID: 1945843) Rosati M … Grimaldi G (Nucleic acids research 1991) 3 4 58
  4. The human genome contains hundreds of genes coding for finger proteins of the Krüppel type. (PMID: 2505992) Bellefroid EJ … Martial JA (DNA (Mary Ann Liebert, Inc.) 1989) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for ZNF84 Gene

Sources for ZNF84 Gene

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