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Aliases for ZNF84 Gene

Aliases for ZNF84 Gene

  • Zinc Finger Protein 84 2 3 5
  • Zinc Finger Protein HPF2 3 4
  • Zinc Finger Protein 84 (HPF2) 2
  • HPF2 3

External Ids for ZNF84 Gene

Previous GeneCards Identifiers for ZNF84 Gene

  • GC12P131135
  • GC12P133187
  • GC12P131801
  • GC12P131390
  • GC12P132224
  • GC12P132124
  • GC12P133613

Summaries for ZNF84 Gene

GeneCards Summary for ZNF84 Gene

ZNF84 (Zinc Finger Protein 84) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF268.

UniProtKB/Swiss-Prot for ZNF84 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF84 Gene

Genomics for ZNF84 Gene

Regulatory Elements for ZNF84 Gene

Enhancers for ZNF84 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12G132597 1.3 Ensembl ENCODE 89.6 -439.0 -438972 1.8 HDGF ARNT YBX1 ZNF2 ZNF143 ZNF548 ZNF263 SP3 REST ZNF662 ZNF140 ZNF84 EP400 ZNF26 ZNF605 DDX51 ZNF891 SFSWAP ENSG00000255933 GOLGA3
GH12G132954 1 ENCODE 37.8 -81.6 -81550 2.4 ATF1 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 ETS1 ZNF766 GLIS2 ZNF84 ENSG00000250790 ZNF891 ZNF140 DDX51 LOC101928597 ZNF10 ENSG00000256825 ZNF268 ZNF605
GH12G132502 2 FANTOM5 Ensembl ENCODE dbSUPER 15 -530.2 -530222 8.5 HDGF PKNOX1 CREB3L1 ARNT ZFP64 ARID4B SIN3A DMAP1 FEZF1 ZNF2 ZNF140 ENSG00000256875 FBRSL1 ZNF26 ZNF10 EP400 ZNF84 GOLGA3 DDX51 ZNF605
GH12G132487 1.6 FANTOM5 ENCODE dbSUPER 15 -545.2 -545208 9.3 FOXA2 ARID4B SIN3A ZBTB7B ZNF143 ZNF263 ZHX2 REST ZNF579 SMARCA4 FBRSL1 ZNF140 ENSG00000256875 ZNF10 EP400 EP400NL ZNF891 ZNF84 GOLGA3 DDX51
GH12G132559 1 ENCODE 21.1 -476.7 -476697 2.2 ATF1 AGO1 ARID4B SIN3A TCF12 ZNF121 GATA2 ELK1 ZNF143 ZMIZ1 ZNF84 ZNF605 DDX51 EP400 POLE ENSG00000256875 ENSG00000279700 LOC100996573
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF84 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF84 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000059575 215 2200 MLX CREB3L1 ARID4B SIN3A DMAP1 SLC30A9 ZNF766 ZNF207 ZNF143 FOS

Genomic Location for ZNF84 Gene

133,037,286 bp from pter
133,063,304 bp from pter
26,019 bases
Plus strand

Genomic View for ZNF84 Gene

Genes around ZNF84 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF84 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF84 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF84 Gene

Proteins for ZNF84 Gene

  • Protein details for ZNF84 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 84
    Protein Accession:
    Secondary Accessions:
    • B2RAK5
    • D3DXJ1
    • Q3ZCV9
    • Q5D057
    • Q86XU8
    • Q9NNX7
    • Q9UC17
    • Q9UC18

    Protein attributes for ZNF84 Gene

    738 amino acids
    Molecular mass:
    85457 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF84 Gene

Post-translational modifications for ZNF84 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF84 Gene

Domains & Families for ZNF84 Gene

Gene Families for ZNF84 Gene

Protein Domains for ZNF84 Gene

Suggested Antigen Peptide Sequences for ZNF84 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF84: view

Function for ZNF84 Gene

Molecular function for ZNF84 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF84 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding NAS 2505992
GO:0008270 zinc ion binding NAS 2505992
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF84: view
genes like me logo Genes that share phenotypes with ZNF84: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF84 Gene

Localization for ZNF84 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF84 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF84 gene
Compartment Confidence
nucleus 3

Gene Ontology (GO) - Cellular Components for ZNF84 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF84: view

Pathways & Interactions for ZNF84 Gene

SuperPathways for ZNF84 Gene

No Data Available

Interacting Proteins for ZNF84 Gene

Gene Ontology (GO) - Biological Process for ZNF84 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF84: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF84 Gene

Drugs & Compounds for ZNF84 Gene

No Compound Related Data Available

Transcripts for ZNF84 Gene

Unigene Clusters for ZNF84 Gene

Zinc finger protein 84:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF84 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b · 5c · 5d · 5e ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c · 8d · 8e ^ 9
SP1: - - - - - - -
SP2: - - - - - - - - -
SP3: - - - - - - - -
SP4: - - - - - - - - - -
SP5: - - - - - - - - - - - - -
SP6: - - - - - - -
SP7: - - - - -
SP8: - - - - - -
SP9: - - - - -
SP10: - - - - -
SP11: - -
SP12: - -

Relevant External Links for ZNF84 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF84 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF84 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF84 Gene:


SOURCE GeneReport for Unigene cluster for ZNF84 Gene:


Evidence on tissue expression from TISSUES for ZNF84 Gene

  • Nervous system(4.7)
  • Lung(4.2)
genes like me logo Genes that share expression patterns with ZNF84: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF84 Gene

Orthologs for ZNF84 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF84 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF84 34 35
  • 99.64 (n)
(Bos Taurus)
Mammalia ZNF84 34
  • 89.57 (n)
-- 35
  • 83 (a)
(Canis familiaris)
Mammalia ZNF26 34
  • 88.89 (n)
-- 35
  • 83 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG14711 36
  • 50 (a)
Kr 36
  • 49 (a)
CG3485 36
  • 44 (a)
crol 36
  • 43 (a)
CG15436 36
  • 42 (a)
CG5245 36
  • 41 (a)
CG12299 36
  • 40 (a)
CG18555 36
  • 40 (a)
CG11762 36
  • 39 (a)
BG:DS02740.8 36
  • 37 (a)
CG11247 36
  • 37 (a)
CG8319 36
  • 37 (a)
Neu2 36
  • 36 (a)
CG10543 36
  • 33 (a)
CG7987 36
  • 31 (a)
CG8301 36
  • 31 (a)
CG18476 36
  • 30 (a)
CG18011 36
  • 25 (a)
(Caenorhabditis elegans)
Secernentea M03D4.4 36
  • 32 (a)
Species where no ortholog for ZNF84 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for ZNF84 Gene

Gene Tree for ZNF84 (if available)
Gene Tree for ZNF84 (if available)

Paralogs for ZNF84 Gene

(562) SIMAP similar genes for ZNF84 Gene using alignment to 9 proteins: Pseudogenes for ZNF84 Gene

genes like me logo Genes that share paralogs with ZNF84: view

Variants for ZNF84 Gene

Sequence variations from dbSNP and Humsavar for ZNF84 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000003753 -- 133,056,299(+) CCCAG(C/G)CTGGA intron-variant
rs1000338308 -- 133,062,934(+) TCTAT(A/G)TGAAC utr-variant-3-prime
rs1000515326 -- 133,050,876(+) TCTTC(A/C)CTTTA intron-variant
rs1000687647 -- 133,044,838(+) GAACC(C/T)GGGAG intron-variant
rs1000737825 -- 133,044,698(+) ATCAC(A/G/T)AGGTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF84 Gene

Variant ID Type Subtype PubMed ID
dgv1590n100 CNV gain 25217958
dgv1592n100 CNV gain 25217958
dgv1593n100 CNV gain 25217958
dgv330e199 CNV deletion 23128226
dgv917n106 CNV deletion 24896259
esv27162 CNV gain+loss 19812545
esv2759923 CNV loss 17122850
esv3631326 CNV loss 21293372
esv3631327 CNV gain 21293372
nsv1048027 CNV gain 25217958
nsv1054933 CNV gain 25217958
nsv1071081 CNV deletion 25765185
nsv525745 CNV gain 19592680
nsv9048 CNV gain 18304495
nsv9049 CNV gain 18304495

Relevant External Links for ZNF84 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for ZNF84 Gene

Disorders for ZNF84 Gene

Relevant External Links for ZNF84

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZNF84 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF84 Gene

Publications for ZNF84 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Members of the zinc finger protein gene family sharing a conserved N- terminal module. (PMID: 1945843) Rosati M. … Grimaldi G. (Nucleic Acids Res. 1991) 3 4 64
  4. The human genome contains hundreds of genes coding for finger proteins of the Kruppel type. (PMID: 2505992) Bellefroid E.J. … Martial J.A. (DNA 1989) 3 4 64
  5. PAK4 promotes kinase-independent stabilization of RhoU to modulate cell adhesion. (PMID: 26598620) Dart A.E. … Wells C.M. (J. Cell Biol. 2015) 3 64

Products for ZNF84 Gene

Sources for ZNF84 Gene

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