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ZNF84 Gene

protein-coding   GIFtS: 44
GCID: GC12P133613

Zinc Finger Protein 84

(Previous name: zinc finger protein 84 (HPF2))
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger Protein 841 2
Zinc Finger Protein HPF22 3
Zinc Finger Protein 84 (HPF2)1
HPF22

External Ids:    HGNC: 131591   Entrez Gene: 76372   Ensembl: ENSG000001980407   UniProtKB: P515233   

Export aliases for ZNF84 gene to outside databases

Previous GC identifers: GC12P131135 GC12P133187 GC12P131801 GC12P131390 GC12P132224 GC12P132124


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZNF84 Gene:
ZNF84 (zinc finger protein 84) is a protein-coding gene. An important paralog of this gene is ZNF334.

UniProtKB/Swiss-Prot: ZNF84_HUMAN, P51523
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NT_024477.15  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZNF84 gene promoter:
         Pax-2b   Pax-2   FOXD3   FOXJ2   Pax-2a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF84 promoter sequence
   Search Chromatin IP Primers for ZNF84

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF84


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.33   Ensembl cytogenetic band:  12q24.33   HGNC cytogenetic band: 12q24.33

ZNF84 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF84 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P133613:  view genomic region     (about GC identifiers)

Start:
133,613,878 bp from pter      End:
133,639,885 bp from pter
Size:
26,008 bases      Orientation:
plus strand

0 alternative location:

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ZNF84_HUMAN, P51523 (See protein sequence)
Recommended Name: Zinc finger protein 84  
Size: 738 amino acids; 85457 Da
Secondary accessions: B2RAK5 D3DXJ1 Q3ZCV9 Q5D057 Q86XU8 Q9NNX7 Q9UC17 Q9UC18

Explore the universe of human proteins at neXtProt for ZNF84: NX_P51523

Explore proteomics data for ZNF84 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ZNF84 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001120844.1  NP_001276900.1  NP_001276901.1  NP_003419.3  

    ENSEMBL proteins: 
     ENSP00000437949   ENSP00000445549   ENSP00000442963   ENSP00000387416   ENSP00000445820  
     ENSP00000445958   ENSP00000331465   ENSP00000438982   ENSP00000437636   ENSP00000439130  
     ENSP00000376133  

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    antibodies-online proteins for ZNF84 (3 products) 

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR001909 Krueppel-associated_box
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry P51523

    ProtoNet protein and cluster: P51523

    2 Blocks protein domains:
    IPB001909 KRAB box
    IPB007086 C2H2-type zinc finger signature


    UniProtKB/Swiss-Prot: ZNF84_HUMAN, P51523
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 19 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    Find genes that share domains with ZNF84           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZNF84_HUMAN, P51523
    Function: May be involved in transcriptional regulation

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding NAS2505992
    GO:0008270zinc ion binding NAS2505992
    GO:0046872metal ion binding ----
         
    Find genes that share ontologies with ZNF84           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for ZNF84

    miRNA
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    miRTarBase miRNAs that target ZNF84:
    hsa-mir-92a-3p (MIRT049366), hsa-mir-26b-5p (MIRT028911)

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    4 qRT-PCR Assays for microRNAs that regulate ZNF84:
    hsa-miR-656 hsa-miR-633 hsa-miR-1263 hsa-miR-4275
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF84


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZNF84_HUMAN, P51523: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--

    Find genes that share ontologies with ZNF84           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF84
    Interactions:

        Search GeneGlobe Interaction Network for ZNF84

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--

    Find genes that share ontologies with ZNF84           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZNF84



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ZNF84 gene (4 alternative transcripts): 
    NM_001127372.2  NM_001289971.1  NM_001289972.1  NM_003428.5  

    Unigene Cluster for ZNF84:

    Zinc finger protein 84
    Hs.445019  [show with all ESTs]
    Unigene Representative Sequence: NM_003428
    18 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000543758 ENST00000539354 ENST00000542874 ENST00000438628 ENST00000540031
    ENST00000539098 ENST00000539686 ENST00000536123 ENST00000327668(uc009zza.3)
    ENST00000543310 ENST00000545299 ENST00000542358 ENST00000441040 ENST00000538726
    ENST00000535439 ENST00000543124 ENST00000455093 ENST00000392319(uc001ulm.4 uc009zyy.3 uc009zyz.3)

    miRNA
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    4 qRT-PCR Assays for microRNAs that regulate ZNF84:
    hsa-miR-656 hsa-miR-633 hsa-miR-1263 hsa-miR-4275
    SwitchGear 3'UTR luciferase reporter plasmidZNF84 3' UTR sequence
    Inhib. RNA
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      QuantiFast Probe-based Assays in human, mouse, rat ZNF84

    Additional mRNA sequence: 

    AK054847.1 AK055603.1 AK314232.1 BC036656.1 BC048350.1 BC062552.1 M27878.1 X60156.2 

    13 DOTS entries:

    DT.97764240  DT.211879  DT.111116  DT.97803400  DT.95265492  DT.92423451  DT.121213901  DT.92423449 
    DT.121214066  DT.95265485  DT.95364864  DT.95364866  DT.121213898 

    Selected AceView cDNA sequences (see all 131):

    AA928816 AI625085 AU131364 AW949471 BU902392 AI817337 CA445618 X60156 
    AU134480 AA922661 CA392686 BF436843 BX505317 BM678788 AW771804 AA587259 
    BQ786992 AI222356 BM991826 CD512791 AI686105 BQ892924 AU127242 AU127827 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ZNF84 (see all 13)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b · 5c · 5d · 5e ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c · 8d · 8e ^ 9
    SP1:                                -     -     -     -                 -                 -     -                                                         
    SP2:                          -     -     -     -     -                 -                 -     -                 -                                       
    SP3:                                -     -     -     -                 -                 -     -                 -                                       
    SP4:                          -     -     -     -     -     -           -                 -     -                 -                                       
    SP5:                                -     -     -     -                 -                 -     -                 -     -     -     -     -     -         


    ECgene alternative splicing isoforms for ZNF84

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZNF84 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ZNF84 Expression
    About this image

    ZNF84 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZNF84 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.445019
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of mammals.

    Orthologs for ZNF84 gene from Selected species (see all 5)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    dog
    (Canis familiaris)
    Mammalia ZNF261 zinc finger protein 26 88.89(n)
    89.97(a)
      100686099  XM_003433428.1  XP_003433476.1 


    ENSEMBL Gene Tree for ZNF84 (if available)
    TreeFam Gene Tree for ZNF84 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZNF84 gene
    ZNF3342  ZNF4202  ZNF780A2  ZNF6652  ZNF72  ZNF232  ZNF33A2  RBAK2  
    ZNF7172  ZNF302  ZNF5732  ZNF33B2  ZNF5402  ZNF2512  ZNF6052  ZNF1892  
    ZNF5712  ZNF6302  ZNF3372  ZNF2832  ZNF4042  ZNF1352  ZNF4842  ZNF122  
    ZNF3452  ZNF1842  ZNF6992  ZNF412  ZNF6152  ZNF4702  ZNF5692  
    Selected SIMAP similar genes for ZNF84 using alignment to 9 protein entries:     ZNF84_HUMAN (see all proteins) (see all similar genes):
    ZNF649    ZNF818P    FIK    ZNF625-ZNF20    kr-znf3    ZNF177
    ZNF763    ZNF559    ZSCAN16    ZFP90    ZNF577    ZNF268
    ZNF721    ZNF350    ZNF320    ZNF625    ZNF615    ZNF83

    Find genes that share paralogs with ZNF84           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for ZNF84
    PGOHUM00000238410 PGOHUM00000250582


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZNF84 (see all 273)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1150994341,2
    C--133612017(+) AAGAAA/GCCAGT 2 -- us2k10--------
    rs1174377741,2
    C--133612641(+) TCACAA/GTAGTG 2 -- us2k10--------
    rs1145555331,2
    C--133612945(+) TTCCAC/TATTGG 2 -- us2k10--------
    rs1149793271,2
    C--133612989(+) GGTGAC/GTTCTA 2 -- us2k10--------
    rs1158559591,2
    C--133613136(+) CCCATC/GTTGTC 2 -- us2k10--------
    rs1162657711,2
    C--133613167(+) CAAATA/TATCAA 2 -- us2k10--------
    rs1155312751,2
    C--133613184(+) TAGTAC/TAGAGC 2 -- us2k10--------
    rs1409038411,2
    C--133613435(+) GGGCGA/CGGTGG 2 -- us2k10--------
    rs1401064471,2
    C--133613711(+) CTCAAA/GAAAAT 2 -- us2k10--------
    rs1142249751,2
    C--133613790(+) TCACTC/GCGTCT 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for ZNF84 (133613878 - 133639885 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for ZNF84:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv330e199CNV Deletion23128226
    nsv899835CNV Loss21882294
    nsv9048CNV Gain18304495
    nsv899836CNV Gain21882294
    nsv9049CNV Gain18304495
    nsv525745CNV Gain19592680
    esv27162CNV Gain+Loss19812545
    essv8522CNV CNV17122850
    dgv538e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZNF84 gene, integrated from 10 sources (see all 13):
    (articles sorted by number of sources associating them with ZNF84)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. Members of the zinc finger protein gene family sharing a conserved N- terminal module. (PubMed id 1945843)1, 2 Rosati M.... Grimaldi G. (Nucleic Acids Res. 1991)
    4. The human genome contains hundreds of genes coding for finger proteins of the Kruppel type. (PubMed id 2505992)1, 2 Bellefroid E.J....Martial J.A. (DNA 1989)
    5. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    6. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    7. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (Sci. Signal. 2011)
    8. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    9. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (amp 2008)
    10. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7637 HGNC: 13159 AceView: ZNF84 Ensembl:ENSG00000198040 euGenes: HUgn7637
    ECgene: ZNF84 H-InvDB: ZNF84

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZNF84 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
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    Patent Information for ZNF84 gene:
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    GeneCards and IP:
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