ZNF84 Gene
protein-coding GIFtS: 44
GCID: GC12P133613
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|
zinc finger protein 84(Previous name: zinc finger protein 84 (HPF2) )
| |
Aliases
for ZNF84 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger Protein 841 2 | | HPF21 2 | | Zinc Finger Protein HPF22 3 | | Zinc Finger Protein 84 (HPF2)1 |
Export aliases for ZNF84 gene to outside databasesPrevious GC identifers: GC12P131135 GC12P133187 GC12P131801 GC12P131390 GC12P132224 GC12P132124 |
Summaries
for ZNF84 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: ZNF84_HUMAN, P51523Function: May be involved in transcriptional regulation
|
Genomic Views
for ZNF84 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000012.11 NC_018923.1 NT_024477.14
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZNF84 gene promoter:
Pax-2b Pax-2 FOXD3 FOXJ2 Pax-2a
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZNF84
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF84 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 12q24.33 Ensembl cytogenetic band: 12q24.33 HGNC cytogenetic band: 12q24.33ZNF84 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12P133613: view genomic region
(about GC identifiers)
Start:
|
133,613,878 bp from pter |
End:
|
133,639,885 bp from pter |
Size:
|
26,008 bases |
Orientation:
|
plus strand |
0 alternative location:
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Proteins
for ZNF84 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZNF84_HUMAN, P51523 (See
protein sequence)Recommended Name: Zinc finger protein 84 Size: 738 amino acids; 85457 Da
Subcellular location: Nucleus (Probable)
Secondary accessions: B2RAK5 D3DXJ1 Q3ZCV9 Q5D057 Q86XU8 Q9NNX7 Q9UC17 Q9UC18Explore the universe of human proteins at neXtProt for ZNF84: NX_P51523
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P51523
ZNF84 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001120844.1 NP_003419.3
ENSEMBL proteins: ENSP00000437949 ENSP00000445549 ENSP00000442963 ENSP00000387416 ENSP00000445820 ENSP00000445958 ENSP00000331465 ENSP00000438982 ENSP00000437636 ENSP00000439130 ENSP00000376133
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
ZNF84 for ontologies About GeneDecksing
ZNF84 Antibody Products:
Assay Products for ZNF84: |
Protein
Domains /
Families
for ZNF84 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZNF84 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P51523ProtoNet protein and cluster: P51523 2 Blocks protein families: IPB001909 KRAB box IPB007086 C2H2-type zinc finger signature
UniProtKB/Swiss-Prot: ZNF84_HUMAN, P51523Similarity: Belongs to the krueppel C2H2-type zinc-finger protein familySimilarity: Contains 19 C2H2-type zinc fingersSimilarity: Contains 1 KRAB domain |
Function
for ZNF84 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ZNF84_HUMAN, P51523Function: May be involved in transcriptional regulation
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF84 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF84 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): ZNF84 (NM_003428) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF84 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF84 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF84 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
ZNF84 for ontologies About GeneDecksing
|
Pathways & Interactions
for ZNF84 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF84
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
NAS | -- |
ZNF84 for ontologies About GeneDecksing
|
Drugs & Compounds
for ZNF84 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZNF84
Search CenterWatch for drugs/clinical trials and news about ZNF84
|
Transcripts
for ZNF84 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZNF84 gene (2 alternative transcripts): NM_001127372.1 NM_003428.4 Unigene Cluster for ZNF84: Zinc finger protein 84 Hs.445019 [show with all ESTs]Unigene Representative Sequence: NM_00342818 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000543758 ENST00000539354 ENST00000542874 ENST00000438628 ENST00000540031
ENST00000539098 ENST00000539686 ENST00000536123 ENST00000327668(uc009zza.3)
ENST00000543310 ENST00000545299 ENST00000542358 ENST00000441040 ENST00000538726
ENST00000535439 ENST00000543124 ENST00000455093 ENST00000392319(uc001ulm.4 uc009zyy.3 uc009zyz.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF84 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF84 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): ZNF84 (NM_003428) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF84 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF84 |
Additional cDNA sequence: AK054847.1 AK055603.1 AK314232.1 BC036656.1 BC048350.1 BC062552.1 M27878.1 X60156.2 15 DOTS entries: DT.97764240 DT.211879 DT.111116 DT.97803400 DT.95265492 DT.121214062 DT.92423451 DT.121213901 DT.92423449 DT.100714092 DT.121214066 DT.95265485 DT.95364864 DT.95364866 DT.121213898 24/131 AceView cDNA sequences (see all 131): BF436843 AI625085 AU131364 CA445618 AU134480 BU902392 AA928816 AA922661 X60156 CA392686 AW949471 AI817337 BQ787271 BQ050996 AV727502 CF528950 BC062552 AL599919 BM477785 BV199103 AL041644 AA424285 AI686105 AK055603
GeneLoc Exon Structure
5/13 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF84 (see all 13) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | · | 4c | ^ | 5a | · | 5b | · | 5c | · | 5d | · | 5e | ^ | 6a | · | 6b | ^ | 7 | ^ | 8a | · | 8b | · | 8c | · | 8d | · | 8e | ^ | 9 |
|---|
|
| SP1: | | | | | | | | | | | - | | - | | - | | - | | | | | | - | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | - | | - | | - | | - | | - | | | | | | - | | | | | | - | | - | | | | | | - | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | - | | - | | - | | - | | | | | | - | | | | | | - | | - | | | | | | - | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | - | | - | | - | | - | | - | | - | | | | - | | | | | | - | | - | | | | | | - | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | - | | - | | - | | - | | | | | | - | | | | | | - | | - | | | | | | - | | - | | - | | - | | - | | - | | | |
ECgene alternative splicing isoforms for ZNF84
|
Expression
for ZNF84 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZNF84 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See ZNF84 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZNF84
SOURCE GeneReport for Unigene cluster: Hs.445019
SABiosciences Custom PCR Arrays for ZNF84
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF84
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF84 |
Orthologs
for ZNF84 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for ZNF84 gene from 1/8 species (see all 8) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
-- |
-- |
32(a) |
1 → many |
GL343557.1(371826-420180) |
ENSEMBL Gene Tree for ZNF84 (if available)
TreeFam Gene Tree for ZNF84 (if available) |
Paralogs
for ZNF84 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ZNF84 gene
- ZNF1752 ZNF6742 LOC1002875152 ZNF6142 ZNF4322 ZNF6132 ZNF262 ZNF3502
- ZNF812 ZNF6492 ZNF6052 ZNF5772 ZNF6302 ZFP372 ZNF4842 ENSG000002296312
- ZNF1822 ZNF412 ZNF2682 LOC1009964642 ZNF6152 ZNF3002
18/551 SIMAP similar genes for ZNF84 using alignment to 9 protein entries: ZNF84_HUMAN (see all proteins)
(see all similar genes):ZNF559 ZNF818P kr-znf3 ZNF763 ZNF124 ZSCAN16
ZNF577 ZFP90 ZNF268 ZNF721 ZNF625 ZNF436
ZNF81 ZFP41 ZFS-4 ZNF10 ZNF585A ZNF761
ZNF84 for paralogs About GeneDecksing
2 Pseudogenes.org Pseudogenes for ZNF84
PGOHUM00000238410 PGOHUM00000250582
|
Genomic Variants
for ZNF84 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 12 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZNF84 (133613878 - 133639885 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 8 variations for ZNF84
7 CNVs: 86695 76243 3002 66384 3903 30626 66386
1 Indel: 33264 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF84 |
|
Disorders
/ Diseases
for ZNF84 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for ZNF84 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZNF84 gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with ZNF84) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Members of the zinc finger protein gene family sharing a conserved N- terminal module. (PubMed id 1945843)1, 2 Rosati M.... Grimaldi G. (1991)
- The human genome contains hundreds of genes coding for finger proteins of the Kruppel type. (PubMed id 2505992)1, 2 Bellefroid E.J....Martial J.A. (1989)
- System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Assignment to chromosome 12q24.33, gene organization and splicing of the human KRAB/FPB containing zinc finger gene ZNF84. (PubMed id 11856868)1 Rosati M....Grimaldi G. (2001)
|
External Searches for ZNF84 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZNF84 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZNF84 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZNF84 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZNF84 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZNF84 gene:
Search GeneIP for patents involving ZNF84
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZNF84 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ZNF84 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZNF84 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF84 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ZNF84 | | OriGene 3'-UTR Clone for ZNF84 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF84 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF84 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF84 |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF84 |
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