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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZNF839 Gene

protein-coding   GIFtS: 45
GCID: GC14P102786

Zinc Finger Protein 839

(Previous name: chromosome 14 open reading frame 131)
(Previous symbol: C14orf131)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Zinc Finger Protein 8391 2
C14orf1311 2 3
Renal Carcinoma Antigen NY-REN-502 3
Chromosome 14 Open Reading Frame 1311

External Ids:    HGNC: 203451   Entrez Gene: 557782   Ensembl: ENSG000000229767   UniProtKB: A8K0R73   

Export aliases for ZNF839 gene to outside databases

Previous GC identifers: GC14P101855 GC14P082969


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ZNF839 Gene: 
ZNF839 (zinc finger protein 839) is a protein-coding gene. Diseases associated with ZNF839 include renal cell carcinoma, and among its related super-pathways are Gene Expression. GO annotations related to this gene include zinc ion binding.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NT_026437.12  NC_018925.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZNF839 gene promoter:
         CREB   Sp1   p53   AP-1   deltaCREB   ATF-2   c-Jun   Ik-3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF839 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZNF839

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF839


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32.31   Ensembl cytogenetic band:  14q32.31   HGNC cytogenetic band: 14q32.32

ZNF839 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF839 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P102786:  view genomic region     (about GC identifiers)

Start:
102,783,714 bp from pter      End:
102,809,044 bp from pter
Size:
25,331 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZN839_HUMAN, A8K0R7 (See protein sequence)
Recommended Name: Zinc finger protein 839  
Size: 811 amino acids; 87484 Da
Sequence caution: Sequence=BAA92026.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=CAD62594.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: B3KSD2 Q53FH5 Q6GPI5 Q86TU1 Q9BQ86 Q9NUU3
Alternative splicing: 3 isoforms:  A8K0R7-1   A8K0R7-2   A8K0R7-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ZNF839: NX_A8K0R7

Explore proteomics data for ZNF839 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_A8K0R7

  • ZNF839 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ZNF839 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001254756.1  NP_001254757.1  NP_060805.3  

    ENSEMBL proteins: 
     ENSP00000453363   ENSP00000453109   ENSP00000399863   ENSP00000453515   ENSP00000453137  
     ENSP00000452983   ENSP00000453415   ENSP00000452819   ENSP00000454159   ENSP00000453744  
     ENSP00000262236  
    Reactome Protein details: A8K0R7
    Human Recombinant Protein Products for ZNF839: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry A8K0R7

    ProtoNet protein and cluster: A8K0R7

    UniProtKB/Swiss-Prot: ZN839_HUMAN, A8K0R7
    Similarity: Contains 1 C2H2-type zinc finger


    ZNF839 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008270zinc ion binding ----
    GO:0046872metal ion binding IEA--
         
    ZNF839 for ontologies           About GeneDecksing


    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ZNF839 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Generic Transcription Pathway
    Generic Transcription Pathway0.47
    Gene Expression0.47

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2        Reactome Pathways for ZNF839
        Generic Transcription Pathway
    Gene Expression



    ZNF839 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF839

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    4 Interacting proteins for ZNF839 (A8K0R73 ENSP000003998634) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    YWHAEP622583, ENSP000002643354I2D: score=3 STRING: ENSP00000264335
    YWHAZP631043, ENSP000003095034I2D: score=2 STRING: ENSP00000309503
    WNK1Q9H4A33, ENSP000003130594I2D: score=1 STRING: ENSP00000313059
    YWHAGP619813I2D: score=2 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZNF839 (ZN839)

    Search CenterWatch for drugs/clinical trials and news about ZNF839 / ZN839

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZNF839 gene (3 alternative transcripts): 
    NM_001267827.1  NM_001267828.1  NM_018335.4  

    Unigene Cluster for ZNF839:

    Zinc finger protein 839
    Hs.743359  [show with all ESTs]
    Unigene Representative Sequence: NM_018335
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000558850 ENST00000559185 ENST00000442396 ENST00000559098(uc001ylq.1)
    ENST00000561251 ENST00000560568 ENST00000559155 ENST00000558490 ENST00000558462
    ENST00000557803(uc001ylt.2) ENST00000560112 ENST00000420933 ENST00000262236(uc001ylo.2 uc010awk.1 uc001ylp.2 uc001ylr.2 uc001yls.2)

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    hsa-miR-23b hsa-miR-130a* hsa-miR-23a hsa-miR-23c hsa-miR-340
    SwitchGear 3'UTR luciferase reporter plasmidZNF839 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AF155112.1 AK001994.1 AK093342.1 AK125678.1 AK223312.1 AK289632.1 AL137478.1 BC006222.2 
    BC006228.2 BC042659.1 BC073137.1 BX248266.1 

    13 DOTS entries:

    DT.315053  DT.100700350  DT.101968671  DT.100783111  DT.120750184  DT.117932  DT.100644853  DT.75102740 
    DT.92020368  DT.95198829  DT.99934129  DT.91969533  DT.97766481 

    24/107 AceView cDNA sequences (see all 107):

    AA427941 D31113 CF529776 CR613117 BQ673711 CR621855 AI097367 NM_018335 
    AW519238 CR610461 AL137478 BG108371 CR609610 BM980945 AK001994 BX248266 
    AK125678 BM711133 CA495337 BC073137 BQ019232 AI298424 AF155112 BI256242 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF839 (see all 8)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c · 5d ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11
    SP1:        -     -                                                     -                 -                                 
    SP2:                                                                    -                 -                                 
    SP3:                                                                    -                 -                 -     -         
    SP4:                                                                    -                                                   
    SP5:                                                                                      -                                 


    ECgene alternative splicing isoforms for ZNF839

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZNF839 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ZNF839 Expression
    About this image


    See ZNF839 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZNF839

    SOURCE GeneReport for Unigene cluster: Hs.743359
        SABiosciences Custom PCR Arrays for ZNF839
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for ZNF839 gene from 4/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfp8391 , 5 zinc finger protein 8391, 5 68.1(n)1
    54.02(a)1
      12 (60.83 cM)5
    728051  NM_028365.21  NP_082641.11 
     1108502795 
    chicken
    (Gallus gallus)
    Aves ZNF8391 zinc finger protein 839 53.81(n)
    39.57(a)
      423466  XM_421374.3  XP_421374.3 
    lizard
    (Anolis carolinensis)
    Reptilia ZNF8396
    Uncharacterized protein
    41(a)
    1 ↔ 1
    GL343232.1(1804021-1807614)
    zebrafish
    (Danio rerio)
    Actinopterygii znf8396
    zinc finger protein 839
    43(a)
    1 ↔ 1
    17(31687929-31692046)


    ENSEMBL Gene Tree for ZNF839 (if available)
    TreeFam Gene Tree for ZNF839 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZNF839 gene
    2 SIMAP similar genes for ZNF839 using alignment to 8 protein entries:     ZN839_HUMAN (see all proteins):
    DKFZp434M1123    C14orf131

    ZNF839 for paralogs           About GeneDecksing


    4 Pseudogenes.org Pseudogenes for ZNF839
    PGOHUM00000250043 PGOHUM00000250044 PGOHUM00000241171 PGOHUM00000262160


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/690 SNPs in ZNF839 are shown (see all 690)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1466630551,2
    --102781723(+) TCCCTA/GTAATA 1 -- us2k10--------
    rs340024161,2
    C,F--102781750(+) TGCGGA/TGAGCT 1 -- us2k17Minor allele frequency- T:0.15NA CSA WA 248
    rs1863933791,2
    --102781773(+) GGATTA/GGGTTT 1 -- us2k10--------
    rs349926691,2
    C--102781779(+) GGTTTC/-TTTGA 1 -- us2k11Minor allele frequency- -:0.50NA 2
    rs71461721,2
    C,F,H--102781843(+) CTGAGT/AGTCCG 1 -- us2k15Minor allele frequency- A:0.01NS EA WA 536
    rs1402356441,2
    --102781914(+) CATAAA/GATCTT 1 -- us2k10--------
    rs1458739121,2
    --102782077(+) GGGAGA/GCCGAG 1 -- us2k10--------
    rs101457491,2
    C,F,A--102782109(+) AGGAGC/TTCGAG 1 -- us2k14Minor allele frequency- T:0.50NA 8
    rs361532771,2
    C--102782138(+) TGAAA-/CCCCCA 1 -- us2k10--------
    rs2010297151,2
    C--102782158(+) AAAAT-/ACACACACACAC
    ACACACACACACAC
    ACACA
    1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ZNF839 (102783714 - 102809044 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for ZNF839:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv827062CNV Gain20364138
    esv29657CNV Gain19812545

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    2 diseases for ZNF839:    About MalaCards
    renal cell carcinoma    


    ZNF839 for disorders           About GeneDecksing


    Export disorders for ZNF839 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZNF839 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ZNF839)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    2. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
    3. A human MAP kinase interactome. (PubMed id 20936779)1 Bandyopadhyay S....Ideker T. (2010)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    5. The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121)2 Heilig R.... Weissenbach J. (2003)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    7. Antigens recognized by autologous antibody in patients with renal- cell carcinoma. (PubMed id 10508479)1 Scanlan M.J....Old L.J. (1999)
    8. Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (PubMed id 8125298)1 Maruyama K. and Sugano S. (1994)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 55778 HGNC: 20345 AceView: C14orf131 Ensembl:ENSG00000022976 euGenes: HUgn55778
    ECgene: ZNF839 H-InvDB: ZNF839

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZNF839 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZNF839 gene:
    Search GeneIP for patents involving ZNF839

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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