ZNF839 Gene
protein-coding GIFtS: 44
GCID: GC14P102786
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|
zinc finger protein 839(Previous name: chromosome 14 open reading frame 131 )
(Previous symbol: C14orf131)
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Aliases
for ZNF839 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger Protein 8391 2 | | C14orf1311 2 3 | | Renal Carcinoma Antigen NY-REN-502 3 | | Chromosome 14 Open Reading Frame 1311 |
Export aliases for ZNF839 gene to outside databasesPrevious GC identifers: GC14P101855 GC14P082969 |
Summaries
for ZNF839 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for ZNF839 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000014.8 NC_018925.1 NT_026437.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZNF839 gene promoter:
CREB Sp1 p53 AP-1 deltaCREB ATF-2 c-Jun Ik-3
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZNF839
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF839 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 14q32.31 Ensembl cytogenetic band: 14q32.31 HGNC cytogenetic band: 14q32.32ZNF839 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 14 GeneLoc Exon Structure GeneLoc location for GC14P102786: view genomic region
(about GC identifiers)
Start:
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102,783,714 bp from pter |
End:
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102,809,044 bp from pter |
Size:
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25,331 bases |
Orientation:
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plus strand |
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Proteins
for ZNF839 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZN839_HUMAN, A8K0R7 (See
protein sequence)Recommended Name: Zinc finger protein 839 Size: 811 amino acids; 87484 Da
Sequence caution: Sequence=BAA92026.1; Type=Erroneous initiation; Note=Translation N-terminally extended;Sequence=CAD62594.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: B3KSD2 Q53FH5 Q6GPI5 Q86TU1 Q9BQ86 Q9NUU3Alternative splicing: 3 isoforms: A8K0R7-1 A8K0R7-2 A8K0R7-5 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for ZNF839: NX_A8K0R7
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_A8K0R7
ZNF839 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001254756.1 NP_001254757.1 NP_060805.3
ENSEMBL proteins: ENSP00000453363 ENSP00000453109 ENSP00000399863 ENSP00000453515 ENSP00000453137 ENSP00000452983 ENSP00000453415 ENSP00000452819 ENSP00000454159 ENSP00000453744 ENSP00000262236 Reactome Protein details: A8K0R7
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005622 | intracellular |
IEA | -- |
ZNF839 for ontologies About GeneDecksing
ZNF839 Antibody Products:
Assay Products for ZNF839: |
Protein
Domains /
Families
for ZNF839 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZNF839 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry A8K0R7ProtoNet protein and cluster: A8K0R7 UniProtKB/Swiss-Prot: ZN839_HUMAN, A8K0R7Similarity: Contains 1 C2H2-type zinc finger |
Function
for ZNF839 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF839 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF839 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: ZNF839 (NM_018335) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF839 | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat ZNF839 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF839 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008270 | zinc ion binding |
IEA | -- |
ZNF839 for ontologies About GeneDecksing
|
Pathways & Interactions
for ZNF839 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Generic Transcription Pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 
Reactome Pathways for ZNF839
ZNF839 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF839
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
4 Interacting proteins for ZNF839 (A8K0R73 ENSP000003998634) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for ZNF839 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZNF839
Search CenterWatch for drugs/clinical trials and news about ZNF839 / ZN839
|
Transcripts
for ZNF839 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZNF839 gene (3 alternative transcripts): NM_001267827.1 NM_001267828.1 NM_018335.4 Unigene Cluster for ZNF839: Zinc finger protein 839 Hs.743359 [show with all ESTs]Unigene Representative Sequence: NM_01833513 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000558850 ENST00000559185 ENST00000442396 ENST00000559098(uc001ylq.1)
ENST00000561251 ENST00000560568 ENST00000559155 ENST00000558490 ENST00000558462
ENST00000557803(uc001ylt.2) ENST00000560112 ENST00000420933 ENST00000262236(uc001ylo.2 uc010awk.1 uc001ylp.2 uc001ylr.2 uc001yls.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF839 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF839 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ZNF839 (NM_018335) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF839 | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat ZNF839 |
Additional cDNA sequence: AF155112.1 AK001994.1 AK093342.1 AK125678.1 AK223312.1 AK289632.1 AL137478.1 BC006222.2 BC006228.2 BC042659.1 BC073137.1 BX248266.1 13 DOTS entries: DT.315053 DT.100700350 DT.101968671 DT.100783111 DT.120750184 DT.117932 DT.100644853 DT.75102740 DT.92020368 DT.95198829 DT.99934129 DT.91969533 DT.97766481 24/107 AceView cDNA sequences (see all 107): AI097367 CF529776 BC073137 D31113 BM980945 AA427941 CR613117 CR621855 BQ673711 AW519238 NM_018335 BX248266 AK001994 CA495337 AL137478 BG108371 CR609610 AK125678 BM711133 CR610461 CD250716 AA044752 CB161873 BX367755
GeneLoc Exon Structure
5/8 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF839 (see all 8) About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5a | · | 5b | · | 5c | · | 5d | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9a | · | 9b | ^ | 10a | · | 10b | ^ | 11 |
|---|
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| SP1: | | | - | | - | | | | | | | | | | | | | | | | | | - | | | | | | - | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | - | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | - | | | | | | - | | - | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | |
ECgene alternative splicing isoforms for ZNF839
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Expression
for ZNF839 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZNF839 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See ZNF839 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZNF839
SOURCE GeneReport for Unigene cluster: Hs.743359
SABiosciences Custom PCR Arrays for ZNF839
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF839
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ZNF839 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF839 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF839 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF839 |
Orthologs
for ZNF839 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for ZNF839 gene from 5/12 species (see all 12) About this table
ENSEMBL Gene Tree for ZNF839 (if available)
TreeFam Gene Tree for ZNF839 (if available) |
Paralogs
for ZNF839 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ZNF839 gene
2 SIMAP similar genes for ZNF839 using alignment to 8 protein entries: ZN839_HUMAN (see all proteins):DKFZp434M1123 C14orf131
ZNF839 for paralogs About GeneDecksing
4 Pseudogenes.org Pseudogenes for ZNF839
PGOHUM00000250043 PGOHUM00000250044 PGOHUM00000241171 PGOHUM00000262160
|
Genomic Variants
for ZNF839 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 14 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZNF839 (102783714 - 102809044 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for ZNF839
1 CNV: 71967 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF839 |
|
Disorders
/ Diseases
for ZNF839 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ZNF839 for disorders About GeneDecksing
3  diseases for ZNF839: About MalaCardsrenal carcinoma carcinoma renal cell carcinoma
Export disorders for ZNF839 gene to outside databases
|
Publications
for ZNF839 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZNF839 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ZNF839) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- A human MAP kinase interactome. (PubMed id 20936779)1 Bandyopadhyay S....Ideker T. (2010)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121)2 Heilig R.... Weissenbach J. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Antigens recognized by autologous antibody in patients with renal- cell carcinoma. (PubMed id 10508479)1 Scanlan M.J....Old L.J. (1999)
- Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (PubMed id 8125298)1 Maruyama K. and Sugano S. (1994)
|
External Searches for ZNF839 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZNF839 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZNF839 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZNF839 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZNF839 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZNF839 gene:
Search GeneIP for patents involving ZNF839
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZNF839 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ZNF839 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF839 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF839 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZNF839 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF839 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF839 |
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 | | | ZNF839 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF839 |
|  |  |  | | | | Search ThermoFisher Antibodies for ZNF839 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat ZNF839 |
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