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ZNF839 Gene

protein-coding   GIFtS: 42
GCID: GC14P102786

Zinc Finger Protein 839

(Previous name: chromosome 14 open reading frame 131)
(Previous symbol: C14orf131)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger Protein 8391 2
C14orf1311 2 3
Renal Carcinoma Antigen NY-REN-502 3
Chromosome 14 Open Reading Frame 1311

External Ids:    HGNC: 203451   Entrez Gene: 557782   Ensembl: ENSG000000229767   UniProtKB: A8K0R73   

Export aliases for ZNF839 gene to outside databases

Previous GC identifers: GC14P101855 GC14P082969


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZNF839 Gene:
ZNF839 (zinc finger protein 839) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the ZNF839 gene promoter:
         CREB   Sp1   p53   AP-1   deltaCREB   ATF-2   c-Jun   Ik-3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF839 promoter sequence
   Search Chromatin IP Primers for ZNF839

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF839


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32.31   Ensembl cytogenetic band:  14q32.31   HGNC cytogenetic band: 14q32.32

ZNF839 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF839 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P102786:  view genomic region     (about GC identifiers)

Start:
102,783,714 bp from pter      End:
102,809,044 bp from pter
Size:
25,331 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ZN839_HUMAN, A8K0R7 (See protein sequence)
Recommended Name: Zinc finger protein 839  
Size: 811 amino acids; 87484 Da
Sequence caution: Sequence=BAA92026.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=CAD62594.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: B3KSD2 Q53FH5 Q6GPI5 Q86TU1 Q9BQ86 Q9NUU3
Alternative splicing: 3 isoforms:  A8K0R7-1   A8K0R7-2   A8K0R7-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ZNF839: NX_A8K0R7

Explore proteomics data for ZNF839 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ZNF839 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001254756.1  NP_001254757.1  NP_060805.3  

    ENSEMBL proteins: 
     ENSP00000453363   ENSP00000453109   ENSP00000399863   ENSP00000453515   ENSP00000453137  
     ENSP00000452983   ENSP00000453415   ENSP00000452819   ENSP00000454159   ENSP00000453744  
     ENSP00000262236  
    Reactome Protein details: A8K0R7

    ZNF839 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for ZNF839

     
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    Cloud-Clone Corp. ELISAs for ZNF839
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry A8K0R7

    ProtoNet protein and cluster: A8K0R7

    UniProtKB/Swiss-Prot: ZN839_HUMAN, A8K0R7
    Similarity: Contains 1 C2H2-type zinc finger


    Find genes that share domains with ZNF839           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with ZNF839           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ZNF839
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    miRNA
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    miRTarBase miRNAs that target ZNF839:
    hsa-mir-26b-5p (MIRT029938)

    Block miRNA regulation of human, mouse, rat ZNF839 using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate ZNF839:
    hsa-miR-23b hsa-miR-130a* hsa-miR-23a hsa-miR-23c hsa-miR-340
    SwitchGear 3'UTR luciferase reporter plasmidZNF839 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat ZNF839

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector: ZNF839 (NM_018335)
    Browse Sino Biological Human cDNA Clones
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF839


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol2
    plasma membrane1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ZNF839 About    
    See pathways by source

    SuperPathContained pathways About
    1Gene Expression
    Generic Transcription Pathway0.40
    Gene Expression0.40


    Find genes that share SuperPaths with ZNF839           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for ZNF839
        Generic Transcription Pathway


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF839
    Interactions:

        Search GeneGlobe Interaction Network for ZNF839

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    4 Interacting proteins for ZNF839 (A8K0R73 ENSP000003998634) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    YWHAEP622583, ENSP000002643354I2D: score=3 STRING: ENSP00000264335
    YWHAZP631043, ENSP000003095034I2D: score=2 STRING: ENSP00000309503
    WNK1Q9H4A33, ENSP000003130594I2D: score=1 STRING: ENSP00000313059
    YWHAGP619813I2D: score=2 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZNF839 (ZN839)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ZNF839 gene (3 alternative transcripts): 
    NM_001267827.1  NM_001267828.1  NM_018335.4  

    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000558850 ENST00000559185 ENST00000442396 ENST00000559098(uc001ylq.1)
    ENST00000561251 ENST00000560568 ENST00000559155 ENST00000558490 ENST00000558462
    ENST00000557803(uc001ylt.2) ENST00000560112 ENST00000420933 ENST00000262236(uc001ylo.2 uc010awk.1 uc001ylp.2 uc001ylr.2 uc001yls.2)

    miRNA
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    5 qRT-PCR Assays for microRNAs that regulate ZNF839:
    hsa-miR-23b hsa-miR-130a* hsa-miR-23a hsa-miR-23c hsa-miR-340
    SwitchGear 3'UTR luciferase reporter plasmidZNF839 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ZNF839
    Predesigned siRNA for gene silencing in human, mouse, rat ZNF839
    Clone
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    OriGene clones in human, mouse for ZNF839 (see all 7)
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    GenScript: all cDNA clones in your preferred vector: ZNF839 (NM_018335)
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    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ZNF839
      QuantiTect SYBR Green Assays in human, mouse, rat ZNF839
      QuantiFast Probe-based Assays in human, mouse, rat ZNF839

    Selected AceView cDNA sequences (see all 107):

    BC073137 BG108371 CR610461 CR613117 BM980945 BQ673711 AW519238 AI097367 
    D31113 CR621855 CF529776 AK125678 CA495337 AK001994 CR609610 AA427941 
    BX248266 AL137478 NM_018335 BM711133 BG119277 AF155112 AI699350 CB161873 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ZNF839 (see all 8)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c · 5d ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11
    SP1:        -     -                                                     -                 -                                 
    SP2:                                                                    -                 -                                 
    SP3:                                                                    -                 -                 -     -         
    SP4:                                                                    -                                                   
    SP5:                                                                                      -                                 


    ECgene alternative splicing isoforms for ZNF839

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZNF839 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ZNF839 Expression
    About this image

    ZNF839 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZNF839 Protein Expression
        Custom PCR Arrays for ZNF839
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF839

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ZNF839 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfp8391 , 5 zinc finger protein 8391, 5 67.29(n)1
    53.32(a)1
      12 (60.83 cM)5
    728051  NM_001199785.11  NP_001186714.11 
     1108502795 
    chicken
    (Gallus gallus)
    Aves ZNF8396
    zinc finger protein 839
    36(a)
    1 ↔ 1
    5(49479157-49490005)
    lizard
    (Anolis carolinensis)
    Reptilia ZNF8396
    zinc finger protein 839
    42(a)
    1 ↔ 1
    GL343232.1(1804021-1807614)
    zebrafish
    (Danio rerio)
    Actinopterygii znf8396
    zinc finger protein 839
    21(a)
    1 ↔ 1
    17(31682466-31698955) ENSDARG00000076988


    ENSEMBL Gene Tree for ZNF839 (if available)
    TreeFam Gene Tree for ZNF839 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZNF839 gene
    2 SIMAP similar genes for ZNF839 using alignment to 8 protein entries:     ZN839_HUMAN (see all proteins):
    DKFZp434M1123    C14orf131

    Find genes that share paralogs with ZNF839           About GenesLikeMe


    4 Pseudogenes.org Pseudogenes for ZNF839
    PGOHUM00000250043 PGOHUM00000250044 PGOHUM00000241171 PGOHUM00000262160


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZNF839 (see all 690)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1466630551,2
    --102781723(+) TCCCTA/GTAATA 1 -- us2k10--------
    rs340024161,2
    C,F--102781750(+) TGCGGA/TGAGCT 1 -- us2k17Minor allele frequency- T:0.15NA CSA WA 248
    rs1863933791,2
    --102781773(+) GGATTA/GGGTTT 1 -- us2k10--------
    rs349926691,2
    C--102781779(+) GGTTTC/-TTTGA 1 -- us2k11Minor allele frequency- -:0.50NA 2
    rs71461721,2
    C,F,H--102781843(+) CTGAGT/AGTCCG 1 -- us2k15Minor allele frequency- A:0.01NS EA WA 536
    rs1402356441,2
    --102781914(+) CATAAA/GATCTT 1 -- us2k10--------
    rs1458739121,2
    --102782077(+) GGGAGA/GCCGAG 1 -- us2k10--------
    rs101457491,2
    C,F,A--102782109(+) AGGAGC/TTCGAG 1 -- us2k14Minor allele frequency- T:0.50NA 8
    rs361532771,2
    C--102782138(+) TGAAA-/CCCCCA 1 -- us2k10--------
    rs2010297151,2
    C--102782158(+) AAAAT-/ACACACACACAC
    ACACACACACACAC
    ACACA
    1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ZNF839 (102783714 - 102809044 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for ZNF839:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv827062CNV Gain20364138
    esv29657CNV Gain19812545

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ZNF839
    DNA2.0 Custom Variant and Variant Library Synthesis for ZNF839

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZNF839 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with ZNF839)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    2. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
    3. A human MAP kinase interactome. (PubMed id 20936779)1 Bandyopadhyay S....Ideker T. (Nat. Methods 2010)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121)2 Heilig R.... Weissenbach J. (Nature 2003)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    7. Antigens recognized by autologous antibody in patients with renal- cell carcinoma. (PubMed id 10508479)1 Scanlan M.J....Old L.J. (Int. J. Cancer 1999)
    8. Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (PubMed id 8125298)1 Maruyama K. and Sugano S. (Gene 1994)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55778 HGNC: 20345 AceView: C14orf131 Ensembl:ENSG00000022976 euGenes: HUgn55778
    ECgene: ZNF839 H-InvDB: ZNF839

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZNF839 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZNF839 gene:
    Search GeneIP for patents involving ZNF839

    GeneCards and IP:
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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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