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ZNF835 Gene

protein-coding   GIFtS: 40
GCID: GC19M057174

Zinc Finger Protein 835

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger Protein 8351 2
BC37295_32

External Ids:    HGNC: 343321   Entrez Gene: 904852   Ensembl: ENSG000001279037   UniProtKB: Q9Y2P03   

Export aliases for ZNF835 gene to outside databases

Previous GC identifers: GC19M061868 GC19M053484


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZNF835 Gene:
ZNF835 (zinc finger protein 835) is a protein-coding gene. An important paralog of this gene is ZNF436.

UniProtKB/Swiss-Prot: ZN835_HUMAN, Q9Y2P0
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NT_011109.17  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZNF835 gene promoter:
         Nkx3-1   Sox5   Nkx3-1 v1   Nkx5-1   GATA-2   C/EBPalpha   Nkx3-1 v2   FOXO4   Nkx3-1 v3   Hlf   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF835 promoter sequence
   Search Chromatin IP Primers for ZNF835

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF835


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.43   Ensembl cytogenetic band:  19q13.43   HGNC cytogenetic band: 19q13.43

ZNF835 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF835 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M057174:  view genomic region     (about GC identifiers)

Start:
57,174,020 bp from pter      End:
57,183,151 bp from pter
Size:
9,132 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ZN835_HUMAN, Q9Y2P0 (See protein sequence)
Recommended Name: Zinc finger protein 835  
Size: 537 amino acids; 59631 Da
Sequence caution: Sequence=AAD23609.1; Type=Erroneous gene model prediction;
Secondary accessions: B7Z5Y0 G3V1S0

Explore the universe of human proteins at neXtProt for ZNF835: NX_Q9Y2P0

Explore proteomics data for ZNF835 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ZNF835 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001005850.2  
    ENSEMBL proteins: 
     ENSP00000444747   ENSP00000470133  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    3 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q9Y2P0

    ProtoNet protein and cluster: Q9Y2P0

    1 Blocks protein domain: IPB007086 C2H2-type zinc finger signature

    UniProtKB/Swiss-Prot: ZN835_HUMAN, Q9Y2P0
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 14 C2H2-type zinc fingers


    Find genes that share domains with ZNF835           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN835_HUMAN, Q9Y2P0
    Function: May be involved in transcriptional regulation

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IBA--
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with ZNF835           About GenesLikeMe


    Animal Models:
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZN835_HUMAN, Q9Y2P0: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    Find genes that share ontologies with ZNF835           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF835
    Interactions:

        Search GeneGlobe Interaction Network for ZNF835

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IBA--

    Find genes that share ontologies with ZNF835           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Tocris compounds for ZNF835 (ZN835)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ZNF835 gene: 
    NM_001005850.2  

    Unigene Cluster for ZNF835:

    Zinc finger protein 835
    Hs.458438  [show with all ESTs]
    Unigene Representative Sequence: NM_001005850
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000537055(uc010ygn.2) ENST00000601659
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      QuantiFast Probe-based Assays in human, mouse, rat ZNF835

    Additional mRNA sequence: 

    AK023017.1 AK299565.1 

    2 DOTS entries:

    DT.121432399  DT.92018153 

    3 AceView cDNA sequences:

    AK023017 AU151540 AU129418 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZNF835 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAGACAGTTC
    ZNF835 Expression
    About this image

    ZNF835 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZNF835 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.458438
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ZNF835 gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    dog
    (Canis familiaris)
    Mammalia ZNF8351 zinc finger protein 835 81.47(n)
    78.21(a)
      102156834  XM_005616089.1  XP_005616146.1 
    chicken
    (Gallus gallus)
    Aves --
    Uncharacterized protein
    36(a)
    many ↔ many
    16(204633-207109)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    26(a)
    many ↔ many
    2(189201393-189219330)


    ENSEMBL Gene Tree for ZNF835 (if available)
    TreeFam Gene Tree for ZNF835 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZNF835 gene
    ZNF4362  ZNF1802  ZNF3222  ZNF712  ZNF5722  ZFP22  ZKSCAN72  ZNF6782  
    ZNF7742  ZNF102  ZFP372  ZSCAN22  ZNF8522  ZNF3292  ZNF5442  ZFP32  
    ZNF6062  ZNF5022  
    Selected SIMAP similar genes for ZNF835 using alignment to 2 protein entries:     ZN835_HUMAN (see all proteins) (see all similar genes):
    ZFP41    ZNF78L1    DKFZp686N14223    ZSCAN16    ZNF818P    kr-znf3
    zf30    HZF16    HZF30    ZNF146    ZNF24    ZNF324
    ZNF658B    ZNF658    DKFZp547L155    DKFZp666C237    HZF36    ZFS-4

    Find genes that share paralogs with ZNF835           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZNF835 (see all 337)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs48013521,2
    C,F,A,H--57173582(+) CTCCCT/CGAGAA 1 -- ds500123Minor allele frequency- C:0.21NS EA NA WA CSA 2352
    rs118801461,2
    C,F,H--57173599(+) caggtG/Aagatg 1 -- ds50013Minor allele frequency- A:0.10NA WA EA 246
    rs775316131,2
    F--57173679(+) CCAGAC/ACAACA 1 -- ds50011Minor allele frequency- A:0.01WA 118
    rs730532141,2
    C,F--57173775(+) TGATAC/TAAGCA 1 -- ds50016Minor allele frequency- T:0.39NA CSA WA EA 364
    rs736173141,2
    C,F--57173863(+) GCCCAC/TTCTAA 1 -- ds50014Minor allele frequency- T:0.24WA CSA 123
    rs730532151,2
    C--57173873(+) AAAATA/C/TTTTTG 1 -- ds50014NA WA EA 360
    rs1145835881,2
    C,F--57173899(+) CCCTTC/ATTCTA 1 -- ds50011Minor allele frequency- A:0.04WA 118
    rs1882820811,2
    --57174044(+) TATTCA/CCTTTA 1 -- ut310--------
    rs1390211511,2
    C--57174294(+) AGGCCA/GAGGCG 1 -- ut310--------
    rs621309451,2
    C,F--57174345(+) ACATGG/ATGAAA 1 -- ut313Minor allele frequency- A:0.50NA 6

    HapMap Linkage Disequilibrium report for ZNF835 (57174020 - 57183151 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for ZNF835:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv587e201CNV Deletion23290073
    esv2719042CNV Deletion23290073
    esv2719045CNV Deletion23290073
    esv2741485CNV Deletion23290073
    esv2719043CNV Deletion23290073
    esv22638CNV Loss19812545
    nsv912521CNV Gain21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZNF835 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with ZNF835)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    2. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (Nature 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 90485 HGNC: 34332 AceView: LOC90485 Ensembl:ENSG00000127903 euGenes: HUgn90485
    ECgene: ZNF835 H-InvDB: ZNF835

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZNF835 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZNF835 gene:
    Search GeneIP for patents involving ZNF835

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

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