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ZNF831 Gene

protein-coding   GIFtS: 40
GCID: GC20P057766

Zinc Finger Protein 831

(Previous name: chromosome 20 open reading frame 174)
(Previous symbol: C20orf174)
  Search for ZNF831
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger Protein 8311 2
C20orf1741 2 3
Chromosome 20 Open Reading Frame 1741
dJ492J12.12

External Ids:    HGNC: 161671   Entrez Gene: 1286112   Ensembl: ENSG000001242037   UniProtKB: Q5JPB23   

Export aliases for ZNF831 gene to outside databases

Previous GC identifers: GC20P057200 GC20P054553


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZNF831 Gene:
ZNF831 (zinc finger protein 831) is a protein-coding gene. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is HIVEP1.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000020.11  NT_011362.11  NC_018931.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZNF831 gene promoter:
         AML1a   AP-2gamma   Arnt   MZF-1   Max   AP-2beta   AP-2alpha   Pax-4a   AP-2alphaA   c-Myc   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for ZNF831

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF831


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13.32   Ensembl cytogenetic band:  20q13.32   HGNC cytogenetic band: 20q13.32

ZNF831 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF831 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P057766:  view genomic region     (about GC identifiers)

Start:
57,766,075 bp from pter      End:
57,834,168 bp from pter
Size:
68,094 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ZN831_HUMAN, Q5JPB2 (See protein sequence)
Recommended Name: Zinc finger protein 831  
Size: 1677 amino acids; 177949 Da
Sequence caution: Sequence=CAI46154.1; Type=Erroneous initiation;
Secondary accessions: Q5TDR4 Q8TCP0

Explore the universe of human proteins at neXtProt for ZNF831: NX_Q5JPB2

Explore proteomics data for ZNF831 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ZNF831 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_848552.1  
    ENSEMBL proteins: 
     ENSP00000360069  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q5JPB2

    ProtoNet protein and cluster: Q5JPB2

    UniProtKB/Swiss-Prot: ZN831_HUMAN, Q5JPB2
    Similarity: Contains 2 C2H2-type zinc fingers


    Find genes that share domains with ZNF831           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding IEA--
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with ZNF831           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for ZNF831:
     Decreased p24 protein expressi  Decreased viability with pacli 

    Animal Models:
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF831
    Interactions:

        Search GeneGlobe Interaction Network for ZNF831

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZNF831 (ZN831)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ZNF831 gene: 
    NM_178457.2  

    Unigene Cluster for ZNF831:

    Zinc finger protein 831
    Hs.473204  [show with all ESTs]
    Unigene Representative Sequence: NM_178457
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000371030(uc002yan.3)
    miRNA
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    hsa-miR-411* hsa-miR-548j hsa-miR-607 hsa-miR-15a hsa-miR-30d hsa-miR-3916 hsa-miR-30a hsa-miR-3613-3p
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      QuantiFast Probe-based Assays in human, mouse, rat ZNF831

    Additional mRNA sequence: 

    AL713683.1 AL833682.1 BC033155.1 

    1 DOTS entry:

    DT.40227214 

    7 AceView cDNA sequences:

    AL833682 AL713683 AI018584 AI660312 AA903335 BC033155 BF307498 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZNF831 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTCTTGTGCC
    ZNF831 Expression
    About this image

    ZNF831 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZNF831 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.473204
        Custom PCR Arrays for ZNF831
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF831

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ZNF831 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfp8311 , 5 zinc finger protein 8311, 5 69.29(n)1
    58.34(a)1
      2 (98.04 cM)5
    1000437571  NM_001099328.11  NP_001092798.11 
     1746435345 
    lizard
    (Anolis carolinensis)
    Reptilia ZNF8316
    zinc finger protein 831
    46(a)
    1 ↔ 1
    GL343770.1(62730-64685)
    zebrafish
    (Danio rerio)
    Actinopterygii znf8316
    zinc finger protein 831
    22(a)
    1 ↔ 1
    11(397635-413290) ENSDARG00000074906
    fruit fly
    (Drosophila melanogaster)
    Insecta shn6
    schnurri
    9(a)
    1 → many
    2R(7046591-7104899)
    worm
    (Caenorhabditis elegans)
    Secernentea sma-96
    Protein SMA-9, isoform i
    8(a)
    1 → many
    X(10769288-10782962) WBGene00004862


    ENSEMBL Gene Tree for ZNF831 (if available)
    TreeFam Gene Tree for ZNF831 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZNF831 gene
    HIVEP12  HIVEP22  HIVEP32  
    1 SIMAP similar gene for ZNF831 using alignment to 1 protein entry:     ZN831_HUMAN:
    ZNF844

    Find genes that share paralogs with ZNF831           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for ZNF831
    PGOHUM00000241205


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZNF831 (see all 1578)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1395912791,2
    Cuntested157767498(+) CTGGAC/TGCCCC 2 T M mis10--------
    rs2002621791,2
    Cuntested157769303(+) TCCATC/TGCCTC 2 R C mis10--------
    rs1823282981,2
    --57764104(+) GGTGGC/TGCACA 1 -- us2k10--------
    rs1876953351,2
    --57764144(+) GGCAAA/GAGAAT 1 -- us2k10--------
    rs2600101,2
    C,F,A,H--57764298(+) catgaG/Agtttt 1 -- us2k121Minor allele frequency- A:0.37NS EA NA WA CSA 2337
    rs733090221,2
    C,F--57764409(+) TTTGAT/CTGTAA 1 -- us2k12Minor allele frequency- C:0.20WA 120
    rs733090241,2
    C--57764421(+) TTTATG/ATAACG 1 -- us2k12Minor allele frequency- A:0.15WA 120
    rs733090271,2
    C,F--57764465(+) CTTGCG/ACAATT 1 -- us2k12Minor allele frequency- A:0.21WA 120
    rs2600091,2
    C,F,A,H--57764486(-) gctgaT/Ctgtta 1 -- us2k16Minor allele frequency- C:0.08NS EA WA 632
    rs784678781,2
    C,F--57764530(+) TCAATG/ATGCTG 1 -- us2k11Minor allele frequency- A:0.03NA 120

    HapMap Linkage Disequilibrium report for ZNF831 (57766075 - 57834168 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for ZNF831:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2223494CNV Deletion18987734
    esv2722630CNV Deletion23290073
    esv2722629CNV Deletion23290073
    nsv3431CNV Insertion18451855
    nsv834020CNV Loss17160897
    nsv819120CNV Loss19587683
    esv8268CNV Loss19470904
    nsv523738CNV Loss19592680
    nsv178602CNV Loss16902084
    nsv834021CNV Gain17160897

    1 Site Specific Mutation Identification with PCR Assay for ZNF831:
    Cosmic IdAA Change
    110307p.S1474F
    SeqTarget long-range PCR primers for resequencing ZNF831
    DNA2.0 Custom Variant and Variant Library Synthesis for ZNF831

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with ZNF831           About GenesLikeMe

    Genetic Association Database (GAD): ZNF831
    Human Genome Epidemiology (HuGE) Navigator: ZNF831 (1 document)

    Export disorders for ZNF831 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZNF831 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with ZNF831)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genomewide association study of movement-related adverse antipsychotic effects. (PubMed id 19875103)1, 4 Aberg K....van den Oord E.J. (Biol. Psychiatry 2010)
    2. Genome-wide association study of blood pressure and hypertension. (PubMed id 19430479)1, 4 Levy D....van Duijn C.M. (Nat. Genet. 2009)
    3. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (Nature 2001)
    4. Diagnostic exome sequencing in persons with severe intellectual disability. (PubMed id 23033978)2 de Ligt J.... Vissers L.E. (N. Engl. J. Med. 2012)
    5. Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. (PubMed id 23128233)1 Jostins L....Cho J.H. (Nature 2012)
    6. Genetic associations of variants in genes encoding HIV-dependency factors required for HIV-1 infection. (PubMed id 21083371)4 Chinn L.W....O'Brien S.J. (J. Infect. Dis. 2010)
    7. Identification of host proteins required for HIV infection through a functional genomic screen. (PubMed id 18187620)1 Brass A.L....Elledge S.J. (Science 2008)
    8. Genome-wide association with select biomarker traits in the Framingham Heart Study. (PubMed id 17903293)4 Benjamin E.J....Vasan R.S. (BMC Med. Genet. 2007)
    9. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 128611 HGNC: 16167 AceView: C20orf174 Ensembl:ENSG00000124203 euGenes: HUgn128611
    ECgene: ZNF831 H-InvDB: ZNF831

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZNF831 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZNF831 gene:
    Search GeneIP for patents involving ZNF831

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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