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Aliases for ZNF831 Gene

Aliases for ZNF831 Gene

  • Zinc Finger Protein 831 2 3 5
  • C20orf174 3 4
  • Chromosome 20 Open Reading Frame 174 2

External Ids for ZNF831 Gene

Previous HGNC Symbols for ZNF831 Gene

  • C20orf174

Previous GeneCards Identifiers for ZNF831 Gene

  • GC20P057200
  • GC20P057766
  • GC20P054553

Summaries for ZNF831 Gene

GeneCards Summary for ZNF831 Gene

ZNF831 (Zinc Finger Protein 831) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is HIVEP1.

Additional gene information for ZNF831 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF831 Gene

Genomics for ZNF831 Gene

GeneHancer (GH) Regulatory Elements for ZNF831 Gene

Promoters and enhancers for ZNF831 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20I059120 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 553.4 -0.9 -868 4.8 CTCF MXI1 ESRRA RFX1 CBFB MAX SIN3A EBF1 BMI1 ZIC2 ZNF831 STX16 MRPS16P2
GH20I059191 Promoter 0.5 EPDnew 550.2 +67.7 67716 0.1 ZNF831 EDN3
GH20I059158 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 17.8 +40.1 40060 9.2 CTCF FOXA2 NFIB GATAD2B RAD21 ZBTB40 FOXA1 GATA3 LCORL NFIC ZNF831 TUBB1 EDN3
GH20I059039 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 11.2 -81.2 -81196 4.8 HDGF PKNOX1 FOXA2 ARID4B NEUROD1 SIN3A DMAP1 ZNF2 ZBTB7B ZNF766 PRELID3B SLMO2-ATP5E NELFCD PPP4R1L ZNF831 LOC101927932 GNAS ENSG00000254419 ATP5F1E
GH20I059145 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 15.5 +25.2 25227 5.8 NFIB CBFA2T3 REST MNT NR2F2 FOXA1 ZFHX2 NFIC POLR2A SCRT2 ZNF831 PHACTR3 STX16 EDN3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF831 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF831 gene promoter:

Genomic Locations for ZNF831 Gene

Genomic Locations for ZNF831 Gene
chr20:59,123,381-59,259,113
(GRCh38/hg38)
Size:
135,733 bases
Orientation:
Plus strand
chr20:57,766,075-57,834,168
(GRCh37/hg19)

Genomic View for ZNF831 Gene

Genes around ZNF831 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF831 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF831 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF831 Gene

Proteins for ZNF831 Gene

  • Protein details for ZNF831 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5JPB2-ZN831_HUMAN
    Recommended name:
    Zinc finger protein 831
    Protein Accession:
    Q5JPB2
    Secondary Accessions:
    • Q5TDR4
    • Q8TCP0

    Protein attributes for ZNF831 Gene

    Size:
    1677 amino acids
    Molecular mass:
    177949 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAI46154.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ZNF831 Gene

Post-translational modifications for ZNF831 Gene

No Post-translational modifications

No data available for DME Specific Peptides for ZNF831 Gene

Domains & Families for ZNF831 Gene

Gene Families for ZNF831 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ZNF831 Gene

Suggested Antigen Peptide Sequences for ZNF831 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ZNF831: view

No data available for UniProtKB/Swiss-Prot for ZNF831 Gene

Function for ZNF831 Gene

Phenotypes From GWAS Catalog for ZNF831 Gene

Gene Ontology (GO) - Molecular Function for ZNF831 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding IBA --
GO:0003676 nucleic acid binding IEA --
GO:0043565 sequence-specific DNA binding IBA --
GO:0044212 transcription regulatory region DNA binding IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF831: view
genes like me logo Genes that share phenotypes with ZNF831: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF831 Gene

Localization for ZNF831 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF831 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for ZNF831 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
genes like me logo Genes that share ontologies with ZNF831: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for ZNF831 Gene

Pathways & Interactions for ZNF831 Gene

SuperPathways for ZNF831 Gene

No Data Available

Interacting Proteins for ZNF831 Gene

Gene Ontology (GO) - Biological Process for ZNF831 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IEA --
GO:0006366 transcription by RNA polymerase II IBA --
GO:0007165 signal transduction IBA --
GO:0007275 multicellular organism development IBA --
genes like me logo Genes that share ontologies with ZNF831: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF831 Gene

Drugs & Compounds for ZNF831 Gene

No Compound Related Data Available

Transcripts for ZNF831 Gene

mRNA/cDNA for ZNF831 Gene

(12) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF831 Gene

Zinc finger protein 831:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF831 Gene

No ASD Table

Relevant External Links for ZNF831 Gene

GeneLoc Exon Structure for
ZNF831
ECgene alternative splicing isoforms for
ZNF831

Expression for ZNF831 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF831 Gene

mRNA differential expression in normal tissues according to GTEx for ZNF831 Gene

This gene is overexpressed in Whole Blood (x7.0) and Spleen (x5.5).

Protein differential expression in normal tissues from HIPED for ZNF831 Gene

This gene is overexpressed in Heart (37.9) and Tlymphocyte (28.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF831 Gene



Protein tissue co-expression partners for ZNF831 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF831 Gene:

ZNF831

SOURCE GeneReport for Unigene cluster for ZNF831 Gene:

Hs.473204

Evidence on tissue expression from TISSUES for ZNF831 Gene

  • Lymph node(4.1)
genes like me logo Genes that share expression patterns with ZNF831: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF831 Gene

Orthologs for ZNF831 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF831 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF831 33 34
  • 99.3 (n)
dog
(Canis familiaris)
Mammalia ZNF831 33 34
  • 76.01 (n)
cow
(Bos Taurus)
Mammalia LOC100140850 33
  • 73.64 (n)
ZNF831 34
  • 60 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp831 33 16 34
  • 69.29 (n)
rat
(Rattus norvegicus)
Mammalia RGD1565819 33
  • 69.01 (n)
oppossum
(Monodelphis domestica)
Mammalia ZNF831 34
  • 34 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 20 (a)
OneToMany
-- 34
  • 7 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia ZNF831 34
  • 46 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii znf831 34
  • 22 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta shn 34
  • 9 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea sma-9 34
  • 8 (a)
OneToMany
Species where no ortholog for ZNF831 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ZNF831 Gene

ENSEMBL:
Gene Tree for ZNF831 (if available)
TreeFam:
Gene Tree for ZNF831 (if available)

Paralogs for ZNF831 Gene

Paralogs for ZNF831 Gene

(1) SIMAP similar genes for ZNF831 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for ZNF831 Gene

genes like me logo Genes that share paralogs with ZNF831: view

Variants for ZNF831 Gene

Sequence variations from dbSNP and Humsavar for ZNF831 Gene

SNP ID Clin Chr 20 pos Variation AA Info Type
rs1000004268 -- 59,167,610(+) A/C genic_upstream_transcript_variant, intron_variant
rs1000083124 -- 59,186,341(+) G/A/C/T genic_upstream_transcript_variant, intron_variant
rs1000123041 -- 59,227,871(+) A/C genic_downstream_transcript_variant, intron_variant
rs1000144065 -- 59,222,914(+) G/A genic_downstream_transcript_variant, intron_variant
rs1000177126 -- 59,228,176(+) A/G genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF831 Gene

Variant ID Type Subtype PubMed ID
dgv2275n106 CNV deletion 24896259
esv2223494 CNV deletion 18987734
esv2722629 CNV deletion 23290073
esv2722630 CNV deletion 23290073
esv3557276 CNV deletion 23714750
esv8268 CNV loss 19470904
nsv1073072 CNV deletion 25765185
nsv178602 CNV deletion 16902084
nsv3431 CNV insertion 18451855
nsv523738 CNV loss 19592680
nsv819120 CNV loss 19587683
nsv834020 CNV loss 17160897
nsv834021 CNV gain 17160897

Variation tolerance for ZNF831 Gene

Residual Variation Intolerance Score: 82.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.34; 63.14% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF831 Gene

Human Gene Mutation Database (HGMD)
ZNF831
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF831

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF831 Gene

Disorders for ZNF831 Gene

Additional Disease Information for ZNF831

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for ZNF831 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF831 Gene

Publications for ZNF831 Gene

  1. Genomewide association study of movement-related adverse antipsychotic effects. (PMID: 19875103) Aberg K … van den Oord EJ (Biological psychiatry 2010) 3 44 58
  2. Genome-wide association study of blood pressure and hypertension. (PMID: 19430479) Levy D … van Duijn CM (Nature genetics 2009) 3 44 58
  3. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P … Rogers J (Nature 2001) 3 4 58
  4. Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. (PMID: 23128233) Jostins L … Cho JH (Nature 2012) 3 58
  5. Diagnostic exome sequencing in persons with severe intellectual disability. (PMID: 23033978) de Ligt J … Vissers LE (The New England journal of medicine 2012) 4 58

Products for ZNF831 Gene

Sources for ZNF831 Gene

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