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ZNF830 Gene

protein-coding   GIFtS: 45
GCID: GC17P033288

Zinc Finger Protein 830

(Previous name: coiled-coil domain containing 16)
(Previous symbol: CCDC16)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger Protein 8301 2     Coiled-Coil Domain-Containing Protein 162 3
CCDC161 2 3     OMCG12
Coiled-Coil Domain Containing 161 2     Hypothetical Protein MGC203982
Orphan Maintenance Of Genome 11 2     

External Ids:    HGNC: 282911   Entrez Gene: 916032   Ensembl: ENSG000001987837   UniProtKB: Q96NB33   

Export aliases for ZNF830 gene to outside databases

Previous GC identifers: GC17P030315 GC17P029474


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZNF830 Gene:
ZNF830 (zinc finger protein 830) is a protein-coding gene. Diseases associated with ZNF830 include cockayne syndrome, and xeroderma pigmentosum.

UniProtKB/Swiss-Prot: ZN830_HUMAN, Q96NB3
Function: May act as a regulator of the cell cycle in embryos by participating in control of M phase (By
similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000017.11  NC_018928.2  NT_010783.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZNF830 gene promoter:
         Elk-1   AML1a   p53   FOXJ2 (long isoform)   STAT3   FOXJ2   XBP-1   CUTL1   LyF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF830 promoter sequence
   Search Chromatin IP Primers for ZNF830

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF830


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q12   Ensembl cytogenetic band:  17q12   HGNC cytogenetic band: 17q12

ZNF830 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF830 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P033288:  view genomic region     (about GC identifiers)

Start:
33,288,549 bp from pter      End:
33,290,205 bp from pter
Size:
1,657 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ZN830_HUMAN, Q96NB3 (See protein sequence)
Recommended Name: Zinc finger protein 830  
Size: 372 amino acids; 41999 Da
Secondary accessions: Q96F60 Q96GZ5 Q9BU38

Explore the universe of human proteins at neXtProt for ZNF830: NX_Q96NB3

Explore proteomics data for ZNF830 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ZNF830 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_443089.3  
    ENSEMBL proteins: 
     ENSP00000463839   ENSP00000354518  

    ZNF830 Human Recombinant Protein Products:

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    LSBio Antibodies in human, mouse, rat for ZNF830

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    ProtoNet protein and cluster: Q96NB3

    UniProtKB/Swiss-Prot: ZN830_HUMAN, Q96NB3
    Similarity: Contains 1 C2H2-type zinc finger


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN830_HUMAN, Q96NB3
    Function: May act as a regulator of the cell cycle in embryos by participating in control of M phase (By
    similarity)

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0005515protein binding IPI--
    GO:0008270zinc ion binding ----
    GO:0046872metal ion binding IEA--
         
    ZNF830 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for ZNF830:
     Increased G2M DNA content  Upregulation of NF-kappaB path 

         5 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Zfp830):
     cellular  embryogenesis  mortality/aging  normal  reproductive system 

    ZNF830 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for ZNF830: Zfp830tm2.2Cota Zfp830tm1Cota

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ZNF830
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ZNF830
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ZNF830

    miRNA
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    8 qRT-PCR Assays for microRNAs that regulate ZNF830:
    hsa-miR-16-2* hsa-miR-513a-3p hsa-miR-373* hsa-miR-338-5p hsa-miR-193a-5p hsa-miR-520g hsa-miR-195* hsa-miR-616*
    SwitchGear 3'UTR luciferase reporter plasmidZNF830 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ZNF830
    Predesigned siRNA for gene silencing in human, mouse, rat ZNF830

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF830


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZN830_HUMAN, Q96NB3: Nucleus (By similarity). Note=Excluded from nucleolus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0016607nuclear speck IEA--

    ZNF830 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF830
    Interactions:

        Search GeneGlobe Interaction Network for ZNF830

    STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

    Selected Interacting proteins for ZNF830 (Q96NB31, 2 ENSP000003545184) via UniProtKB, MINT, STRING, and/or I2D (see all 17)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IKQ131231, 2, ENSP000003963014EBI-3920997,EBI-713456 MINT-8337519 MINT-8332053 STRING: ENSP00000396301
    PCBP1Q153651, 2, ENSP000003055564EBI-3920997,EBI-946095 MINT-8332130 MINT-8338223 STRING: ENSP00000305556
    PRPF8Q6P2Q91, 2, ENSP000003043504EBI-3920997,EBI-538479 MINT-8331855 MINT-8336023 STRING: ENSP00000304350
    SNW1Q135731, 2, ENSP000002615314EBI-3920997,EBI-632715 MINT-8337156 MINT-8332031 STRING: ENSP00000261531
    AQRO603061, 2, ENSP000001564714EBI-3920997,EBI-2512328 MINT-8337266 MINT-8332042 STRING: ENSP00000156471
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    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001832blastocyst growth IEA--
    GO:0007049cell cycle ----
    GO:0007067mitosis IEA--
    GO:0033260nuclear cell cycle DNA replication IEA--

    ZNF830 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZNF830 (ZN830)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ZNF830 gene: 
    NM_052857.3  

    Unigene Cluster for ZNF830:

    Zinc finger protein 830
    Hs.413678  [show with all ESTs]
    Unigene Representative Sequence: NM_052857
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000578339 ENST00000361952(uc002hih.4)
    miRNA
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    8 qRT-PCR Assays for microRNAs that regulate ZNF830:
    hsa-miR-16-2* hsa-miR-513a-3p hsa-miR-373* hsa-miR-338-5p hsa-miR-193a-5p hsa-miR-520g hsa-miR-195* hsa-miR-616*
    SwitchGear 3'UTR luciferase reporter plasmidZNF830 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ZNF830
    Predesigned siRNA for gene silencing in human, mouse, rat ZNF830
    Clone
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    OriGene clones in human, mouse for ZNF830 (see all 7)
    OriGene ORF clones in mouse, rat for ZNF830
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ZNF830 (NM_052857)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF830
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for ZNF830
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ZNF830
      QuantiTect SYBR Green Assays in human, mouse, rat ZNF830
      QuantiFast Probe-based Assays in human, mouse, rat ZNF830

    Additional mRNA sequence: 

    AK055707.1 AK315671.1 BC002913.2 BC009044.1 BC011584.1 

    4 DOTS entries:

    DT.95374937  DT.113704  DT.75113916  DT.99953302 

    Selected AceView cDNA sequences (see all 116):

    BE043032 AI082230 BX098787 AA310726 CR617791 AA806462 AA282045 AA909511 
    AI275024 AA913794 BU687023 NM_052857 BX092810 AL697685 AI914296 AI079480 
    AI566327 CR606415 AW803474 AI217360 CR620924 AI086137 BC009044 AA227558 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZNF830 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTTTGAGGT
    ZNF830 Expression
    About this image

    ZNF830 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZNF830 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.413678
        Custom PCR Arrays for ZNF830
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF830

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ZNF830 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfp8301 , 5 zinc finger protein 8301, 5 83.38(n)1
    84.85(a)1
      11 (50.22 cM)5
    669831  NM_025884.41  NP_080160.21 
     827643455 
    chicken
    (Gallus gallus)
    Aves ZNF8301 zinc finger protein 830 66.11(n)
    64.43(a)
      420966  XM_419050.4  XP_419050.1 
    lizard
    (Anolis carolinensis)
    Reptilia ZNF8306
    zinc finger protein 830
    54(a)
    1 ↔ 1
    6(56670043-56689325)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.165172 Xenopus laevis transcribed sequence with weak similarity more 76.09(n)    BG731294.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.254292 Danio rerio cDNA clone IMAGE6789857, partial cds 74.65(n)    BC053136.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG118391 CG11839 49.02(n)
    38.5(a)
      43006  NM_170198.3  NP_733077.3 


    ENSEMBL Gene Tree for ZNF830 (if available)
    TreeFam Gene Tree for ZNF830 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    7 SNPs for ZNF830    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs794662641,2
    C,F--33290533(+) AAATAT/CTATCT 1 -- ds50011Minor allele frequency- C:0.02NA 120
    rs1425063381,2
    --33290694(+) TCCTTC/GCTTTA 1 -- ds50010--------
    rs9311961,2,4
    ----see VAR_0240592 mis40--------
    rs37443551,2,4
    ----see VAR_0240602 mis40--------
    rs80782171,2,4
    ----see VAR_0309422 mis40--------
    rs80780591,2,4
    ----see VAR_0309412 mis40--------
    rs80738251,2,4
    ----see VAR_0309402 mis40--------

    HapMap Linkage Disequilibrium report for ZNF830 (33288549 - 33290205 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for ZNF830: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ZNF830
    DNA2.0 Custom Variant and Variant Library Synthesis for ZNF830

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    3 diseases for ZNF830:    
    About MalaCards
    cockayne syndrome    xeroderma pigmentosum    malaria

    1 disease from the University of Copenhagen DISEASES database for ZNF830:
    Cockayne syndrome

    ZNF830 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ZNF830
    Human Genome Epidemiology (HuGE) Navigator: ZNF830 (1 document)

    Export disorders for ZNF830 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZNF830 gene, integrated from 10 sources (see all 20):
    (articles sorted by number of sources associating them with ZNF830)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. &quot;Orphan&quot; retrogenes in the human genome. (PubMed id 23066043)1, 3 Ciomborowska J....MakaA8owska I. (Mol. Biol. Evol. 2013)
    2. Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity. (PubMed id 19773279)1, 4 Hosgood H.D....Lan Q. (Occup Environ Med 2009)
    3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. Dynamic protein-protein interaction wiring of the human spliceosome. (PubMed id 22365833)1 Hegele A....Stelzl U. (Mol. Cell 2012)
    7. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    8. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    9. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)
    10. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (Sci. Signal. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 91603 HGNC: 28291 AceView: MGC20398 Ensembl:ENSG00000198783 euGenes: HUgn91603
    ECgene: ZNF830 H-InvDB: ZNF830

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZNF830 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZNF830 gene:
    Search GeneIP for patents involving ZNF830

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