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Aliases for ZNF830 Gene

Aliases for ZNF830 Gene

  • Zinc Finger Protein 830 2 3 5
  • Coiled-Coil Domain-Containing Protein 16 3 4
  • Coiled-Coil Domain Containing 16 2 3
  • Orphan Maintenance Of Genome 1 2 3
  • CCDC16 3 4
  • Hypothetical Protein MGC20398 3
  • OMCG1 3

External Ids for ZNF830 Gene

Previous HGNC Symbols for ZNF830 Gene

  • CCDC16

Previous GeneCards Identifiers for ZNF830 Gene

  • GC17P030315
  • GC17P033288
  • GC17P029474

Summaries for ZNF830 Gene

GeneCards Summary for ZNF830 Gene

ZNF830 (Zinc Finger Protein 830) is a Protein Coding gene. Among its related pathways are Transcription-Coupled Nucleotide Excision Repair (TC-NER) and DNA Double-Strand Break Repair. GO annotations related to this gene include nucleic acid binding.

UniProtKB/Swiss-Prot for ZNF830 Gene

  • Acts as an important regulator of the cell cycle that participates in the maintenance of genome integrity. During cell cycle progression in embryonic fibroblast, prevents replication fork collapse, double-strand break formation and cell cycle checkpoint activation. Controls mitotic cell cycle progression and cell survival in rapidly proliferating intestinal epithelium and embryonic stem cells. During the embryo preimplantation, controls different aspects of M phase. During early oocyte growth, plays a role in oocyte survival by preventing chromosomal breaks formation, activation of TP63 and reduction of transcription.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF830 Gene

Genomics for ZNF830 Gene

Regulatory Elements for ZNF830 Gene

Enhancers for ZNF830 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G035763 1.4 Ensembl ENCODE 41.8 +804.0 804013 3.6 PKNOX1 CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZNF143 ZNF548 ZNF263 ENSG00000270871 LIG3 ZNF830 ENSG00000274756 LINC02001 C17orf50 ENSG00000270894 GAS2L2 GC17P035762 MMP28
GH17G035567 1.1 ENCODE 52.5 +606.9 606943 2.9 HDGF PKNOX1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF302 ENSG00000270871 LIG3 ZNF830 LINC02001 AP2B1 ENSG00000270894 LOC100420062 GAS2L2 GC17P035575 GC17P035574
GH17G035083 2 FANTOM5 Ensembl ENCODE dbSUPER 12.1 +125.6 125633 6.6 HDGF FOXA2 PKNOX1 MLX AGO1 WRNIP1 ARID4B SIN3A DMAP1 YY1 LIG3 RFFL SLFN5 ZNF830 CCT6B NLE1 RPL37P22
GH17G034613 1.5 FANTOM5 ENCODE dbSUPER 11.7 -348.1 -348056 0.4 ZNF493 ZSCAN4 INSM2 KLF17 FEZF1 ZNF2 ZNF155 ZNF23 ZNF302 EGR1 LINC02001 ZNF830 LIG3 TMEM132E ENSG00000278860 GC17M034595
GH17G035725 1.1 Ensembl ENCODE 13.7 +765.0 764957 2.4 PKNOX1 NFIB FEZF1 ZNF48 ZNF366 SCRT2 ZNF350 ZNF263 CEBPB ZEB2 AP2B1 ZNF830 C17orf50 MMP28 LIG3 GAS2L2 RPL17P42 RASL10B
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF830 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF830 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000093422 171 2200 PKNOX1 CREB3L1 ZFP64 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143

Genomic Location for ZNF830 Gene

Chromosome:
17
Start:
34,961,530 bp from pter
End:
34,963,775 bp from pter
Size:
2,246 bases
Orientation:
Plus strand

Genomic View for ZNF830 Gene

Genes around ZNF830 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF830 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF830 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF830 Gene

Proteins for ZNF830 Gene

  • Protein details for ZNF830 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96NB3-ZN830_HUMAN
    Recommended name:
    Zinc finger protein 830
    Protein Accession:
    Q96NB3
    Secondary Accessions:
    • Q96F60
    • Q96GZ5
    • Q9BU38

    Protein attributes for ZNF830 Gene

    Size:
    372 amino acids
    Molecular mass:
    41999 Da
    Quaternary structure:
    • Component of the XAB2 complex, a multimeric protein complex composed of XAB2, PRPF19, AQR, ZNF830, ISY1, and PPIE; this complex binds preferentially to RNA. Interacts with XAB2.

neXtProt entry for ZNF830 Gene

Post-translational modifications for ZNF830 Gene

  • Phosphorylated in response to DNA damage by the cell cycle checkpoint kinases ATR/ATM.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF830 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF830 Gene

Domains & Families for ZNF830 Gene

Protein Domains for ZNF830 Gene

Suggested Antigen Peptide Sequences for ZNF830 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ZNF830: view

No data available for Gene Families and UniProtKB/Swiss-Prot for ZNF830 Gene

Function for ZNF830 Gene

Molecular function for ZNF830 Gene

UniProtKB/Swiss-Prot Function:
Acts as an important regulator of the cell cycle that participates in the maintenance of genome integrity. During cell cycle progression in embryonic fibroblast, prevents replication fork collapse, double-strand break formation and cell cycle checkpoint activation. Controls mitotic cell cycle progression and cell survival in rapidly proliferating intestinal epithelium and embryonic stem cells. During the embryo preimplantation, controls different aspects of M phase. During early oocyte growth, plays a role in oocyte survival by preventing chromosomal breaks formation, activation of TP63 and reduction of transcription.

Gene Ontology (GO) - Molecular Function for ZNF830 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0005515 protein binding IPI 22365833
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF830: view
genes like me logo Genes that share phenotypes with ZNF830: view

Animal Models for ZNF830 Gene

MGI Knock Outs for ZNF830:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZNF830 Gene

Localization for ZNF830 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF830 Gene

Nucleus. Chromosome. Nucleus speckle. Note=Excluded from nucleolus. {ECO:0000250 UniProtKB:Q8R1N0}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF830 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF830 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IBA --
GO:0005654 nucleoplasm TAS --
GO:0005694 chromosome IEA --
GO:0016607 nuclear speck IEA --
genes like me logo Genes that share ontologies with ZNF830: view

Pathways & Interactions for ZNF830 Gene

genes like me logo Genes that share pathways with ZNF830: view

Gene Ontology (GO) - Biological Process for ZNF830 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001541 ovarian follicle development ISS --
GO:0001546 preantral ovarian follicle growth IEA,ISS --
GO:0001832 blastocyst growth IEA --
GO:0006283 transcription-coupled nucleotide-excision repair TAS --
GO:0007049 cell cycle IEA --
genes like me logo Genes that share ontologies with ZNF830: view

No data available for SIGNOR curated interactions for ZNF830 Gene

Drugs & Compounds for ZNF830 Gene

No Compound Related Data Available

Transcripts for ZNF830 Gene

mRNA/cDNA for ZNF830 Gene

Unigene Clusters for ZNF830 Gene

Zinc finger protein 830:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF830 Gene

No ASD Table

Relevant External Links for ZNF830 Gene

GeneLoc Exon Structure for
ZNF830
ECgene alternative splicing isoforms for
ZNF830

Expression for ZNF830 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF830 Gene

Protein differential expression in normal tissues from HIPED for ZNF830 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (25.7), NK cells (8.2), and Pancreas (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZNF830 Gene



Protein tissue co-expression partners for ZNF830 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF830 Gene:

ZNF830

SOURCE GeneReport for Unigene cluster for ZNF830 Gene:

Hs.413678

Evidence on tissue expression from TISSUES for ZNF830 Gene

  • Liver(4.3)
  • Intestine(4.2)
  • Skin(4.2)
genes like me logo Genes that share expression patterns with ZNF830: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF830 Gene

Orthologs for ZNF830 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF830 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF830 34 35
  • 99.64 (n)
cow
(Bos Taurus)
Mammalia ZNF830 34 35
  • 87.28 (n)
dog
(Canis familiaris)
Mammalia ZNF830 34 35
  • 86.48 (n)
mouse
(Mus musculus)
Mammalia Zfp830 34 16 35
  • 83.38 (n)
rat
(Rattus norvegicus)
Mammalia Zfp830 34
  • 82.34 (n)
oppossum
(Monodelphis domestica)
Mammalia ZNF830 35
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZNF830 35
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZNF830 34 35
  • 66.11 (n)
lizard
(Anolis carolinensis)
Reptilia ZNF830 35
  • 54 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia znf830 34
  • 57.69 (n)
Str.16211 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.16517 34
zebrafish
(Danio rerio)
Actinopterygii zgc:77398 34
  • 57.87 (n)
Dr.25429 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.305 34
fruit fly
(Drosophila melanogaster)
Insecta CG11839 34 35
  • 49.02 (n)
Species where no ortholog for ZNF830 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF830 Gene

ENSEMBL:
Gene Tree for ZNF830 (if available)
TreeFam:
Gene Tree for ZNF830 (if available)

Paralogs for ZNF830 Gene

No data available for Paralogs for ZNF830 Gene

Variants for ZNF830 Gene

Sequence variations from dbSNP and Humsavar for ZNF830 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1002989528 -- 34,962,284(+) GGAGA(A/G)AAAAC intron-variant, upstream-variant-2KB, reference, missense
rs1003114732 -- 34,962,842(+) ACTTT(A/G)GAAAA intron-variant, upstream-variant-2KB, utr-variant-3-prime
rs1003321442 -- 34,961,173(+) CACAG(A/C/T)GCTAC intron-variant, upstream-variant-2KB
rs1003378809 -- 34,960,984(+) TGAGA(C/G)ACTAA intron-variant, upstream-variant-2KB
rs1005432992 -- 34,961,452(+) AAAAA(C/G)GGCAA intron-variant, upstream-variant-2KB, utr-variant-5-prime

Variation tolerance for ZNF830 Gene

Residual Variation Intolerance Score: 39.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.30; 88.26% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF830 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF830

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ZNF830 Gene

Disorders for ZNF830 Gene

Relevant External Links for ZNF830

Genetic Association Database (GAD)
ZNF830
Human Genome Epidemiology (HuGE) Navigator
ZNF830
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF830

No disorders were found for ZNF830 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF830 Gene

Publications for ZNF830 Gene

  1. "Orphan" retrogenes in the human genome. (PMID: 23066043) Ciomborowska J. … MakaA8owska I. (Mol. Biol. Evol. 2013) 2 3 64
  2. Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity. (PMID: 19773279) Hosgood H.D. … Lan Q. (Occup Environ Med 2009) 3 46 64
  3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for ZNF830 Gene

Sources for ZNF830 Gene

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