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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZNF827 Gene

protein-coding   GIFtS: 45
GCID: GC04M146681

Zinc Finger Protein 827

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Zinc Finger Protein 8271 2

External Ids:    HGNC: 271931   Entrez Gene: 1524852   Ensembl: ENSG000001516127   UniProtKB: Q17R983   

Export aliases for ZNF827 gene to outside databases

Previous GC identifers: GC04M146902 GC04M142410


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ZNF827 Gene: 
ZNF827 (zinc finger protein 827) is a protein-coding gene. Diseases associated with ZNF827 include smallpox. GO annotations related to this gene include DNA binding and zinc ion binding. An important paralog of this gene is ZNF683.

UniProtKB/Swiss-Prot: ZN827_HUMAN, Q17R98
Function: May be involved in transcriptional regulation (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NT_016354.19  NC_018915.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZNF827 gene promoter:
         GR   Oct-B1   oct-B2   oct-B3   GR-beta   POU2F2   POU2F1   POU2F1a   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF827 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZNF827

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF827


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q31.22   Ensembl cytogenetic band:  4q31.22   HGNC cytogenetic band: 4q31.22

ZNF827 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF827 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M146681:  view genomic region     (about GC identifiers)

Start:
146,678,779 bp from pter      End:
146,859,787 bp from pter
Size:
181,009 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZN827_HUMAN, Q17R98 (See protein sequence)
Recommended Name: Zinc finger protein 827  
Size: 1081 amino acids; 119165 Da
Subcellular location: Nucleus (By similarity)
Secondary accessions: B7ZL52 Q7Z4S7 Q8N279
Alternative splicing: 3 isoforms:  Q17R98-1   Q17R98-2   Q17R98-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ZNF827: NX_Q17R98

Explore proteomics data for ZNF827 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q17R98

  • ZNF827 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ZNF827 Protein Expression
    REFSEQ proteins: NP_849157.2  
    ENSEMBL proteins: 
     ENSP00000421863   ENSP00000423130   ENSP00000368761   ENSP00000424541   ENSP00000424456  

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    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    ZNF827 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZNF: Zinc fingers, C2H2-type

    3 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q17R98

    ProtoNet protein and cluster: Q17R98

    UniProtKB/Swiss-Prot: ZN827_HUMAN, Q17R98
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 9 C2H2-type zinc fingers


    ZNF827 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN827_HUMAN, Q17R98
    Function: May be involved in transcriptional regulation (By similarity)

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0008270zinc ion binding ----
    GO:0046872metal ion binding IEA--
         
    ZNF827 for ontologies           About GeneDecksing


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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF827

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for ZNF827 (ENSP000003687614) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PPP1CAENSP000003260314STRING: ENSP00000326031
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--

    ZNF827 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZNF827 (ZN827)

    Search CenterWatch for drugs/clinical trials and news about ZNF827 / ZN827

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZNF827 gene: 
    NM_178835.3  

    Unigene Cluster for ZNF827:

    Zinc finger protein 827
    Hs.633543  [show with all ESTs]
    Unigene Representative Sequence: AK225805
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000508784(uc003ikn.3) ENST00000513320(uc003ikl.3 uc010iox.3)
    ENST00000379448(uc003ikm.3) ENST00000503462 ENST00000511659 ENST00000515386
    ENST00000509940 ENST00000511534 ENST00000508995 ENST00000513840
    miRNA
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    8/33 QIAGEN miScript miRNA Assays for microRNAs that regulate ZNF827 (see all 33):
    hsa-miR-140-5p hsa-miR-128 hsa-miR-578 hsa-miR-219-5p hsa-miR-766 hsa-miR-4267 hsa-miR-298 hsa-miR-508-5p
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    Additional mRNA sequence: 

    AB074279.1 AF450485.1 AK056492.1 AK091130.1 AK094136.1 AK131430.1 AK225805.1 AL117519.1 
    BC033248.1 BC033655.1 BC033879.1 BC117407.1 BC143577.1 

    6 DOTS entries:

    DT.86845960  DT.101974551  DT.91669774  DT.100772558  DT.121232820  DT.91907705 

    24/166 AceView cDNA sequences (see all 166):

    AW043923 AW294631 BX112429 Z39326 BU608180 BQ424328 BC033248 AI589176 
    AA809788 BF437279 H98869 BE884558 BE747354 AA031947 BM718601 BU616184 
    BQ437718 AI887089 AI149999 BM673064 AI370476 AA779513 AI826095 CD674371 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF827 (see all 8)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b · 15c ^ 16 ^ 17a · 17b
    SP1:              -     -                       -                                                                                   -     -                     
    SP2:                                            -                                                                                   -     -                     
    SP3:                                                                                                                                -     -     -               
    SP4:                                                                                                                                      -     -               
    SP5:                                                                                                                                                            


    ECgene alternative splicing isoforms for ZNF827

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZNF827 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTCTGTACCA
    ZNF827 Expression
    About this image


    See ZNF827 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZNF827

    SOURCE GeneReport for Unigene cluster: Hs.633543
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for ZNF827 gene from 6/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfp8271 , 5 zinc finger protein 8271, 5 89.4(n)1
    93.94(a)1
      8 (37.36 cM)5
    6226751  NM_178267.31  NP_839998.21 
     790284375 
    chicken
    (Gallus gallus)
    Aves ZNF8271 zinc finger protein 827 80.61(n)
    83.16(a)
      422465  XM_420430.3  XP_420430.3 
    lizard
    (Anolis carolinensis)
    Reptilia ZNF8276
    Uncharacterized protein
    79(a)
    1 ↔ 1
    5(117640333-117743590)
    zebrafish
    (Danio rerio)
    Actinopterygii znf8271 zinc finger protein 827 61.76(n)
    60.65(a)
      565077  XM_001919166.3  XP_001919201.3 
    fruit fly
    (Drosophila melanogaster)
    Insecta her6
    hermaphrodite
    14(a)
    1 → many
    2L(16677210-16679383)
    worm
    (Caenorhabditis elegans)
    Secernentea slr-26
    Protein SLR-2, isoform b
    7(a)
    1 → many
    V(18087133-18098119)


    ENSEMBL Gene Tree for ZNF827 (if available)
    TreeFam Gene Tree for ZNF827 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZNF827 gene
    ZNF6832  PRDM12  
    18/34 SIMAP similar genes for ZNF827 using alignment to 4 protein entries:     ZN827_HUMAN (see all proteins) (see all similar genes):
    kr-znf3    DKFZp434J0650    DKFZp686N0199    ZFX    ZFS-6    KLF1
    HZF16    PLAGL1    ZNF72    ZNFN1A2    DKFZp547H249    REST
    ZNF473    ZNF600    ZNF671    ZNF702P    ZNF    ZNF808

    ZNF827 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3331 SNPs in ZNF827 are shown (see all 3331)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2009096941,2
    Cuntested1146823888(+) CTTCTC/TGGCCA 2 K E mis10--------
    rs757389241,2
    F--146681471(+) CACACG/AACACA 1 -- ds50011Minor allele frequency- A:0.03EA 120
    rs125003711,2
    C,F,H--146681477(+) ACACAC/TGGCTT 1 -- ds50019Minor allele frequency- T:0.02NS EA NA 688
    rs1117345191,2
    C--146681651(+) GTGGGA/GGTGGG 1 -- ds50012Minor allele frequency- G:0.04CSA WA 120
    rs1833750251,2
    --146681715(+) GAAGAC/TTGGAT 1 -- ds50010--------
    rs1138034941,2
    C--146681864(+) TTTAAG/CTTTTG 1 -- ds50011Minor allele frequency- C:0.50CSA 2
    rs107153911,2
    C--146681873(+) TGTGG-/T/TT  
            
    TTTTT
    1 -- ds50011NA 2
    rs1996526881,2
    C--146681890(-) AAAGAA/CAAAAA 1 -- ut310--------
    rs752332861,2
    C--146681892(+) TTTGTC/TTTTTG 1 -- ut310--------
    rs1502455241,2
    C--146681969(+) ATAGG-/CCAGGA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for ZNF827 (146678779 - 146859787 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for ZNF827:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2544769CNV Deletion19546169
    esv1522611CNV Insertion17803354
    esv1009413CNV Insertion20482838
    nsv830106CNV Gain17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    2 diseases for ZNF827:    About MalaCards
    smallpox    


    ZNF827 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ZNF827
    Human Genome Epidemiology (HuGE) Navigator: ZNF827 (3 documents)

    Export disorders for ZNF827 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZNF827 gene, integrated from 9 sources (see all 20):
    (articles sorted by number of sources associating them with ZNF827)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genome-wide association study identifies loci influenc ing concentrations of liver enzymes in plasma. (PubMed id 22001757)1, 4 Chambers J.C....Kooner J.S. (2011)
    2. Large-scale genome-wide association studies in East As ians identify new genetic loci influencing metabolic traits. (PubMed id 21909109)1, 4 Kim Y.J....Cho Y.S. (2011)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    4. Coeliac disease associated risk variants in TNFAIP3 and REL implicate altered NF-{kappa}B signalling. (PubMed id 19240061)1, 4 Trynka G....Wijmenga C. (2009)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    7. GWAS of dental caries patterns in the permanent dentit ion. (PubMed id 23064961)1 Shaffer J.R....Marazita M.L. (2013)
    8. The functional interactome landscape of the human hist one deacetylase family. (PubMed id 23752268)1 Joshi P....Cristea I.M. (2013)
    9. A strategy for modulation of enzymes in the ubiquitin system. (PubMed id 23287719)1 Ernst A.... Sidhu S.S. (2013)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 152485 HGNC: 27193 AceView: LOC152485 Ensembl:ENSG00000151612 euGenes: HUgn152485
    ECgene: ZNF827 H-InvDB: ZNF827

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZNF827 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZNF827 gene:
    Search GeneIP for patents involving ZNF827

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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