Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ZNF827 Gene

Aliases for ZNF827 Gene

  • Zinc Finger Protein 827 2 3 5

External Ids for ZNF827 Gene

Previous GeneCards Identifiers for ZNF827 Gene

  • GC04M146902
  • GC04M146681
  • GC04M142410

Summaries for ZNF827 Gene

GeneCards Summary for ZNF827 Gene

ZNF827 (Zinc Finger Protein 827) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is REST.

UniProtKB/Swiss-Prot for ZNF827 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF827 Gene

Genomics for ZNF827 Gene

Regulatory Elements for ZNF827 Gene

Enhancers for ZNF827 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04G145803 1.9 FANTOM5 Ensembl ENCODE dbSUPER 5 +131.8 131756 6.9 HDGF PKNOX1 FOXA2 FEZF1 ETS1 TCF12 GLIS2 GATA2 ZNF207 FOS ENSG00000251687 C4orf51 ZNF827 ENSG00000279481 GC04M145759
GH04G145886 0.9 Ensembl ENCODE 9.4 +50.9 50870 1.8 CTCF CBX3 BHLHE40 NR2F1 CHD1 EBF1 CHD7 RAD21 POU5F1 ZNF827 PIR42534 ENSG00000251687
GH04G145880 0.8 Ensembl ENCODE 8.4 +56.6 56570 3.2 RAD51 USF1 BHLHE40 USF2 MLLT1 RELB ZNF827 PIR42534 ENSG00000251687
GH04G145842 0.8 Ensembl ENCODE 8.1 +95.2 95176 1.4 GATA2 JUN CEBPG FOS GABPA ZNF827 ENSG00000251687 PIR42534
GH04G146273 0.9 FANTOM5 1.9 -334.9 -334890 0.6 TBP PKNOX1 EBF1 RELA ARID3A POLR2A EED RELB ETV6 IKZF2 ZNF827 LSM6 LOC105377472 ENSG00000251010
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF827 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF827 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000174326 1035 3601 HDGF PKNOX1 FOXA2 ARNT ZFP64 WRNIP1 ARID4B SIN3A FEZF1 DMAP1

Genomic Location for ZNF827 Gene

Chromosome:
4
Start:
145,757,627 bp from pter
End:
145,938,635 bp from pter
Size:
181,009 bases
Orientation:
Minus strand

Genomic View for ZNF827 Gene

Genes around ZNF827 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF827 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF827 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF827 Gene

Proteins for ZNF827 Gene

  • Protein details for ZNF827 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q17R98-ZN827_HUMAN
    Recommended name:
    Zinc finger protein 827
    Protein Accession:
    Q17R98
    Secondary Accessions:
    • B7ZL52
    • Q7Z4S7
    • Q8N279

    Protein attributes for ZNF827 Gene

    Size:
    1081 amino acids
    Molecular mass:
    119165 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF827 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF827 Gene

Post-translational modifications for ZNF827 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF827 Gene

Domains & Families for ZNF827 Gene

Gene Families for ZNF827 Gene

Protein Domains for ZNF827 Gene

Suggested Antigen Peptide Sequences for ZNF827 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q17R98

UniProtKB/Swiss-Prot:

ZN827_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF827: view

Function for ZNF827 Gene

Molecular function for ZNF827 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF827 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF827: view
genes like me logo Genes that share phenotypes with ZNF827: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF827 Gene

Localization for ZNF827 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF827 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF827 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF827 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF827: view

Pathways & Interactions for ZNF827 Gene

SuperPathways for ZNF827 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF827 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF827: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF827 Gene

Transcripts for ZNF827 Gene

Unigene Clusters for ZNF827 Gene

Zinc finger protein 827:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF827 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b · 15c ^ 16 ^ 17a · 17b
SP1: - - - - -
SP2: - - -
SP3: - - -
SP4: - -
SP5:
SP6: - -
SP7:
SP8:

Relevant External Links for ZNF827 Gene

GeneLoc Exon Structure for
ZNF827
ECgene alternative splicing isoforms for
ZNF827

Expression for ZNF827 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF827 Gene

Protein differential expression in normal tissues from HIPED for ZNF827 Gene

This gene is overexpressed in Liver (41.8), Urine (19.5), and Lung (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF827 Gene



Protein tissue co-expression partners for ZNF827 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF827 Gene:

ZNF827

SOURCE GeneReport for Unigene cluster for ZNF827 Gene:

Hs.633543

Evidence on tissue expression from TISSUES for ZNF827 Gene

  • Liver(4.1)
genes like me logo Genes that share expression patterns with ZNF827: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF827 Gene

Orthologs for ZNF827 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF827 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF827 34 35
  • 99.78 (n)
dog
(Canis familiaris)
Mammalia ZNF827 34 35
  • 93.85 (n)
cow
(Bos Taurus)
Mammalia ZNF827 34 35
  • 91.57 (n)
mouse
(Mus musculus)
Mammalia Zfp827 34 16 35
  • 89.4 (n)
rat
(Rattus norvegicus)
Mammalia Zfp827 34
  • 89.02 (n)
oppossum
(Monodelphis domestica)
Mammalia ZNF827 35
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZNF827 35
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZNF827 34 35
  • 79.89 (n)
lizard
(Anolis carolinensis)
Reptilia ZNF827 35
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia znf827 34
  • 71.04 (n)
zebrafish
(Danio rerio)
Actinopterygii znf827 34 35
  • 61.99 (n)
fruit fly
(Drosophila melanogaster)
Insecta ken 35
  • 13 (a)
OneToMany
CG11966 35
  • 8 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea blmp-1 35
  • 12 (a)
OneToOne
Species where no ortholog for ZNF827 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZNF827 Gene

ENSEMBL:
Gene Tree for ZNF827 (if available)
TreeFam:
Gene Tree for ZNF827 (if available)

Paralogs for ZNF827 Gene

Variants for ZNF827 Gene

Sequence variations from dbSNP and Humsavar for ZNF827 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1000016675 -- 145,854,886(+) CACAG(A/C)AATTA intron-variant
rs1000026999 -- 145,906,800(+) CTAGA(C/T)AATTT intron-variant
rs1000028648 -- 145,897,983(+) AACCC(C/T)ATCTC intron-variant
rs1000042734 -- 145,864,149(+) CAACA(A/G)GGTGA intron-variant
rs1000059662 -- 145,906,967(+) TTCAA(G/T)AAATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF827 Gene

Variant ID Type Subtype PubMed ID
esv1009413 CNV insertion 20482838
esv1522611 CNV insertion 17803354
esv2544769 CNV deletion 19546169
esv3369279 CNV duplication 20981092
esv3564753 CNV deletion 23714750
esv3569738 CNV loss 25503493
esv3602566 CNV loss 21293372
nsv1073378 CNV deletion 25765185
nsv1109644 CNV deletion 24896259
nsv1126700 CNV deletion 24896259
nsv478398 CNV novel sequence insertion 20440878
nsv830106 CNV gain 17160897
nsv949827 CNV deletion 24416366

Variation tolerance for ZNF827 Gene

Residual Variation Intolerance Score: 5.66% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.54; 29.83% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF827 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF827

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF827 Gene

Disorders for ZNF827 Gene

Relevant External Links for ZNF827

Genetic Association Database (GAD)
ZNF827
Human Genome Epidemiology (HuGE) Navigator
ZNF827
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF827

No disorders were found for ZNF827 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF827 Gene

Publications for ZNF827 Gene

  1. NuRD-ZNF827 recruitment to telomeres creates a molecular scaffold for homologous recombination. (PMID: 25150861) Conomos D. … Pickett H.A. (Nat. Struct. Mol. Biol. 2014) 2 3 64
  2. Large-scale genome-wide association studies in East Asians identify new genetic loci influencing metabolic traits. (PMID: 21909109) Kim Y.J. … Cho Y.S. (Nat. Genet. 2011) 3 46 64
  3. Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma. (PMID: 22001757) Chambers J.C. … Kooner J.S. (Nat. Genet. 2011) 3 46 64
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  5. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G. … Wijmenga C. (Gut 2009) 3 46 64

Products for ZNF827 Gene

Sources for ZNF827 Gene

Content
Loading form....