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ZNF823 Gene

protein-coding   GIFtS: 46
GCID: GC19M011832

Zinc Finger Protein 823

  Search for ZNF823
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger Protein 8231 2
ZFP 36 For A Zinc Finger Protein1 2
Zinc Finger Protein ZFP-362 3
HSZFP362
ZFP-36 For A Zinc Finger Protein2
ZFP363

External Ids:    HGNC: 309361   Entrez Gene: 555522   Ensembl: ENSG000001979337   UniProtKB: P164153   

Export aliases for ZNF823 gene to outside databases

Previous GC identifers: GC19M011700 GC19M011410


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZNF823 Gene:
ZNF823 (zinc finger protein 823) is a protein-coding gene. An important paralog of this gene is ZNF669.

UniProtKB/Swiss-Prot: ZN823_HUMAN, P16415
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NT_011295.12  NC_018930.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for ZNF823
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF823 promoter sequence
   Search Chromatin IP Primers for ZNF823

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF823


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.2   Ensembl cytogenetic band:  19p13.2   HGNC cytogenetic band: 19p13.2

ZNF823 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF823 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M011832:  view genomic region     (about GC identifiers)

Start:
11,832,080 bp from pter      End:
11,849,824 bp from pter
Size:
17,745 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ZN823_HUMAN, P16415 (See protein sequence)
Recommended Name: Zinc finger protein 823  
Size: 610 amino acids; 70270 Da
Sequence caution: Sequence=CAA36064.1; Type=Erroneous initiation;
Secondary accessions: A0PJL4 Q6P4A9

Explore the universe of human proteins at neXtProt for ZNF823: NX_P16415

Explore proteomics data for ZNF823 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ZNF823 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001073962.1  
    ENSEMBL proteins: 
     ENSP00000340683   ENSP00000410654   ENSP00000466840   ENSP00000387514   ENSP00000440162  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR001909 Krueppel-associated_box
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry P16415

    ProtoNet protein and cluster: P16415

    1 Blocks protein domain: IPB001909 KRAB box

    UniProtKB/Swiss-Prot: ZN823_HUMAN, P16415
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 16 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    ZNF823 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN823_HUMAN, P16415
    Function: May be involved in transcriptional regulation

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0046872metal ion binding IEA--
         
    ZNF823 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ZNF823
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    miRNA
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    miRTarBase miRNAs that target ZNF823:
    hsa-mir-192-5p (MIRT026425), hsa-mir-193b-3p (MIRT016394)

    Block miRNA regulation of human, mouse, rat ZNF823 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate ZNF823:
    hsa-miR-188-3p
    SwitchGear 3'UTR luciferase reporter plasmidZNF823 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZN823_HUMAN, P16415: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--

    ZNF823 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF823
    Interactions:

        Search GeneGlobe Interaction Network for ZNF823

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for ZNF823 (P164153 ENSP000003406834) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PAK1Q131533, ENSP000002785684I2D: score=3 STRING: ENSP00000278568
    CDK6ENSP000002657344STRING: ENSP00000265734
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--

    ZNF823 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZNF823 (ZN823)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ZNF823 gene: 
    NM_001080493.2  

    Unigene Cluster for ZNF823:

    Zinc finger protein 823
    Hs.142167  [show with all ESTs]
    Unigene Representative Sequence: NM_001080493
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000341191(uc002msm.2 uc010dyi.1) ENST00000431998 ENST00000586121
    ENST00000440527 ENST00000545749(uc010xmd.1)
    miRNA
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    Block miRNA regulation of human, mouse, rat ZNF823 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate ZNF823:
    hsa-miR-188-3p
    SwitchGear 3'UTR luciferase reporter plasmidZNF823 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ZNF823
    Predesigned siRNA for gene silencing in human, mouse, rat ZNF823
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      QuantiFast Probe-based Assays in human, mouse, rat ZNF823

    Additional mRNA sequence: 

    AK300579.1 AK303213.1 AK308189.1 BC052597.1 BC063560.1 X51760.1 

    4 DOTS entries:

    DT.121463026  DT.100016855  DT.121463175  DT.95273439 

    Selected AceView cDNA sequences (see all 48):

    AI017378 BC052597 AA419037 X51760 BC063560 AA423791 BE883574 CB131908 
    BX953241 AA424784 AI261356 AI417785 AW204741 CB852181 AI073826 AA234320 
    CA775926 AI949668 BG481621 BU685080 AI804312 BF685894 AA974108 CA776145 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF823    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d
    SP1:                                                            
    SP2:                                -                           
    SP3:                          -                                 
    SP4:                          -     -                           


    ECgene alternative splicing isoforms for ZNF823

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZNF823 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ZNF823 Expression
    About this image

    ZNF823 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZNF823 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.142167
        Custom PCR Arrays for ZNF823
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF823

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for ZNF823 gene from Selected species (see all 2)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfp815 zinc finger protein 81   --   17 (17.98 cM) 33329342 


    ENSEMBL Gene Tree for ZNF823 (if available)
    TreeFam Gene Tree for ZNF823 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZNF823 gene
    ZNF6692  ZNF5642  ZNF4902  ZNF4412  ZNF625-ZNF202  ZNF8782  ENSG000002671792  ZNF142  
    ENSG000002697552  ENSG000001968262  ZNF7002  ZNF692  ZNF4402  ZNF4432  ZNF670-ZNF6952  ZNF442  
    ZNF4392  ENSG000001884742  ZNF4912  ZNF5552  ENSG000002688702  ZNF7092  ZNF6252  ZNF7992  
    ZNF202  ZNF7882  ZNF1012  ZNF7912  ZNF4422  ZNF4332  ZNF572  ZNF6272  
    ZNF5632  ENSG000002573552  ZNF1362  ZNF5562  ZNF7632  ENSG000002687442  ZNF8442  ZNF772  
    Selected SIMAP similar genes for ZNF823 using alignment to 5 protein entries:     ZN823_HUMAN (see all proteins) (see all similar genes):
    LOC101928664    ZNF625-ZNF20    ZNF442    ZNF799    ZNF443    ZNF738
    FIK    ZNF563    ZNF44    ZNF688    ZNF818P    ZFS-4
    ZNF274    ZNF627    ZNF55    ZNF709    ZNF224    ZNF669

    ZNF823 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZNF823 (see all 466)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2862781,2
    C,F,A,H--11831589(-) TAACAG/CTTTTG 1 -- int120Minor allele frequency- C:0.06NS EA NA CSA WA 2541
    rs780318811,2
    C,F--11831634(+) TGGAAC/AAAAGC 1 -- int11Minor allele frequency- A:0.02WA 118
    rs2017934321,2
    C--11831699(+) GACTC-/AAAAAA 1 -- int10--------
    rs1468563881,2
    --11831791(+) ATCTGC/TAGCCC 1 -- int10--------
    rs1480070451,2
    C--11831874(+) GTTCTC/TTGAAC 1 -- int10--------
    rs1416986891,2
    C--11831883(+) ACACTC/GATGAT 1 -- int10--------
    rs1505058801,2
    --11832034(+) TTTTGA/GTAAGT 1 -- int10--------
    rs746546161,2
    C,F--11832043(+) GTGTTG/AACATG 1 -- int11Minor allele frequency- A:0.06WA 118
    rs58511,2
    C,F,O,A,H--11832283(-) ATATCC/TTCCAG 1 -- ut3124Minor allele frequency- N:0.00MN NS EA NA WA CSA 2725
    rs1383645411,2
    C--11832369(+) CCCTGC/TAATAT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for ZNF823 (11832080 - 11849824 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for ZNF823:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv522659CNV Loss19592680
    nsv518441CNV Loss19592680
    nsv525966CNV Gain19592680
    nsv911067CNV Gain21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    ZNF823 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ZNF823

    Export disorders for ZNF823 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZNF823 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with ZNF823)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    2. A human MAP kinase interactome. (PubMed id 20936779)1 Bandyopadhyay S....Ideker T. (Nat. Methods 2010)
    3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55552 HGNC: 30936 AceView: HSZFP36 Ensembl:ENSG00000197933 euGenes: HUgn55552
    ECgene: ZNF823 H-InvDB: ZNF823

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZNF823 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZNF823 gene:
    Search GeneIP for patents involving ZNF823

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    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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