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ZNF821 Gene

protein-coding   GIFtS: 44
GCID: GC16M071893

Zinc Finger Protein 821

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): antisense

Quality score for the ORGUL clustered with this gene is 3

Aliases
Zinc Finger Protein 8211 2

External Ids:    HGNC: 280431   Entrez Gene: 555652   Ensembl: ENSG000001029847   UniProtKB: O755413   
ORGUL members:         

Export aliases for ZNF821 gene to outside databases

Previous GC identifers: GC16M070452 GC16M057661


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ZNF821 Gene:
This gene encodes a protein with two C2H2 zinc finger motifs and a score-and-three (23)-amino acid peptide repeat
(STPR) domain. The STPR domain of the encoded protein binds to double stranded DNA and may also contain a nuclear
localization signal, suggesting that this protein interacts with chromosomal DNA. Alternatively spliced
transcript variants encoding multiple isoforms have been observed for this gene. (provided by RefSeq, Jan 2011)

GeneCards Summary for ZNF821 Gene:
ZNF821 (zinc finger protein 821) is a protein-coding gene. An important paralog of this gene is RREB1.

UniProtKB/Swiss-Prot: ZN821_HUMAN, O75541
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the ZNF821 gene promoter:
         AML1a   p53   RREB-1   POU3F2   C/EBPalpha   AREB6   CHOP-10   HSF2   IRF-7A   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF821 promoter sequence
   Search Chromatin IP Primers for ZNF821

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF821


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q22.2   Ensembl cytogenetic band:  16q22.2   HGNC cytogenetic band: 16q22.3

ZNF821 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF821 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M071893:  view genomic region     (about GC identifiers)

Start:
71,893,583 bp from pter      End:
71,929,239 bp from pter
Size:
35,657 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ZN821_HUMAN, O75541 (See protein sequence)
Recommended Name: Zinc finger protein 821  
Size: 412 amino acids; 46794 Da
Secondary accessions: A6NK48 B4DKK4 D3DWS3
Alternative splicing: 2 isoforms:  O75541-1   O75541-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ZNF821: NX_O75541

Explore proteomics data for ZNF821 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ZNF821 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001188481.1  NP_001188482.1  NP_001188483.1  NP_001188485.1  NP_060000.1  

    ENSEMBL proteins: 
     ENSP00000457396   ENSP00000457985   ENSP00000405908   ENSP00000455738   ENSP00000455648  
     ENSP00000455454   ENSP00000456563   ENSP00000456087   ENSP00000456193   ENSP00000458112  
     ENSP00000456031   ENSP00000457202   ENSP00000456106   ENSP00000457068   ENSP00000398089  
     ENSP00000313822  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    3 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry O75541

    ProtoNet protein and cluster: O75541

    1 Blocks protein domain: IPB007086 C2H2-type zinc finger signature

    UniProtKB/Swiss-Prot: ZN821_HUMAN, O75541
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 2 C2H2-type zinc fingers


    Find genes that share domains with ZNF821           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN821_HUMAN, O75541
    Function: May be involved in transcriptional regulation

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with ZNF821           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ZNF821
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    miRNA
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    hsa-mir-335-5p (MIRT016869)

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    2 qRT-PCR Assays for microRNAs that regulate ZNF821:
    hsa-miR-577 hsa-miR-32*
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZN821_HUMAN, O75541: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    Find genes that share ontologies with ZNF821           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF821
    Interactions:

        Search GeneGlobe Interaction Network for ZNF821

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for ZNF821 (O755412, 3 ENSP000003138224) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CCDC85BQ158342, 3, ENSP000003116954MINT-66114 I2D: score=5 STRING: ENSP00000311695
    LURAP1Q96LR23, ENSP000003610484I2D: score=3 STRING: ENSP00000361048
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--

    Find genes that share ontologies with ZNF821           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
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    Browse Tocris compounds for ZNF821 (ZN821)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ZNF821 gene (5 alternative transcripts): 
    NM_001201552.1  NM_001201553.1  NM_001201554.1  NM_001201556.1  NM_017530.2  

    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 20):
    ENST00000568961(uc002fbg.4) ENST00000566987(uc002fbe.3) ENST00000446827(uc002fbf.3)
    ENST00000564134 ENST00000565601(uc010vmj.2) ENST00000562808 ENST00000568666
    ENST00000563827 ENST00000565516 ENST00000562797 ENST00000563878 ENST00000562985
    ENST00000564943 ENST00000569186 ENST00000565843 ENST00000568322 ENST00000562677
    ENST00000561700
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    hsa-miR-577 hsa-miR-32*
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      QuantiTect SYBR Green Assays in human, mouse, rat ZNF821
      QuantiFast Probe-based Assays in human, mouse, rat ZNF821

    Selected AceView cDNA sequences (see all 101):

    CD557216 BX283831 AF070588 CB157198 BC004563 AA364918 CD723155 CR601716 
    CB155916 CD244270 BF311486 BC012116 NM_017530 AA604190 CD722992 BX461795 
    BQ228179 BF312791 H83052 BF982673 BM672507 BM981022 BM682089 BX451755 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ZNF821 (see all 13)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c · 12d · 12e · 12f
    SP1:                          -     -                       -                 -           -     -                                                   
    SP2:                          -     -                 -     -                 -           -                 -                                       
    SP3:                          -     -                 -     -                 -     -     -                                                         
    SP4:                                                                          -                                                                     
    SP5:                                                  -     -                 -     -     -                                                         


    ECgene alternative splicing isoforms for ZNF821

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZNF821 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGTTGTGAA
    ZNF821 Expression
    About this image

    ZNF821 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZNF821 Protein Expression
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ZNF821 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfp8211 , 5 zinc finger protein 8211, 5 89.72(n)1
    95.63(a)1
      8 (57.21 cM)5
    758711  NM_029468.31  NP_083744.21 
     1097055495 
    chicken
    (Gallus gallus)
    Aves ZNF8211 zinc finger protein 821 77.67(n)
    83.37(a)
      415878  XM_414235.3  XP_414235.2 
    lizard
    (Anolis carolinensis)
    Reptilia ZNF8216
    zinc finger protein 821
    67(a)
    1 ↔ 1
    GL343483.1(323196-328534)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.8822 Transcribed sequence with weak similarity to protein more 76.82(n)    BX725497.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5717401 zinc finger protein 821-like 57.85(n)
    60.32(a)
      571740  XM_695359.5  XP_700451.5 
    fruit fly
    (Drosophila melanogaster)
    Insecta peb6
    pebbled
    4(a)
    1 → many
    X(4511602-4520256)


    ENSEMBL Gene Tree for ZNF821 (if available)
    TreeFam Gene Tree for ZNF821 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZNF821 gene
    RREB12  
    3 SIMAP similar genes for ZNF821 using alignment to 9 protein entries:     ZN821_HUMAN (see all proteins):
    LOC55565    ZNF55    ZNF410

    Find genes that share paralogs with ZNF821           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZNF821 (see all 466)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs71888851,2
    C,F,H--71893178(+) GCTGAC/TTACTG 5 -- ds500120Minor allele frequency- T:0.15NA NS EA WA 1882
    rs1381851491,2
    --71893209(+) ACAATA/GTTGCT 5 -- ds50010--------
    rs1834634921,2
    --71893343(+) TATCTA/TCATTA 5 -- ds50010--------
    rs47885661,2
    C,F,H--71893470(+) GAGCAC/TCCTCC 5 -- ds500120Minor allele frequency- T:0.20NA EA NS WA CSA 758
    rs47885671,2
    C,F,A,H--71893498(+) CACCAG/AAAGCC 5 -- ds500128Minor allele frequency- A:0.42NA NS EA WA 2852
    rs1491714741,2
    C--71893782(+) CTCAGA/GTCCAC 5 -- ut310--------
    rs1997471751,2
    --71893877(+) GGGTGA/GGTGGG 5 -- ut310--------
    rs178508691,2
    C,F--71893981(+) CTGTCC/TAACTC 9 L syn1 ut313Minor allele frequency- T:0.01NA EU 5993
    rs2010276781,2
    --71894002(+) ACAGGC/TAGCTG 9 L syn1 ut310--------
    rs2006214421,2
    C--71894055(+) GTCCTC/GGCCAA 9 Q E mis1 ut310--------

    HapMap Linkage Disequilibrium report for ZNF821 (71893583 - 71929239 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for ZNF821:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv267783CNV Insertion20981092
    esv1001782CNV Insertion20482838
    nsv7285OTHER Inversion18451855

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with ZNF821           About GenesLikeMe

    Genetic Association Database (GAD): ZNF821
    Human Genome Epidemiology (HuGE) Navigator: ZNF821 (1 document)

    Export disorders for ZNF821 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZNF821 gene, integrated from 10 sources (see all 12):
    (articles sorted by number of sources associating them with ZNF821)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    2. Large-scale concatenation cDNA sequencing. (PubMed id 9110174)1, 3 Yu W.... Gibbs R.A. (Genome Res. 1997)
    3. A "double adaptor" method for improved shotgun library construction. (PubMed id 8619474)1, 3 Andersson B.... Gibbs R.A. (Anal. Biochem. 1996)
    4. STPR, a 23-amino acid tandem repeat domain, found in the human function-unknown protein ZNF821. (PubMed id 20795678)1 Nonaka Y....Kawano K. (Biochemistry 2010)
    5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (Genomics 2007)
    6. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    7. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (Nature 2005)
    8. The sequence and analysis of duplication-rich human chromosome 16. (PubMed id 15616553)2 Martin J.... Pennacchio L.A. (Nature 2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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      Query String
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55565 HGNC: 28043 AceView: LOC55565 Ensembl:ENSG00000102984 euGenes: HUgn55565
    ECgene: ZNF821 H-InvDB: ZNF821

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZNF821 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZNF821 gene:
    Search GeneIP for patents involving ZNF821

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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