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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ZNF821 Gene

protein-coding GIFtS: 45
GCID: GC16M071893

zinc finger protein 821

Search for ZNF821
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Zinc Finger Protein 821¹ ²

External Ids:	HGNC: 28043¹	Entrez Gene: 55565²	Ensembl: ENSG00000102984⁷	UniProtKB: O75541³

Export aliases for ZNF821 gene to outside databases

Previous GC identifers: GC16M070452 GC16M057661

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ZNF821:

This gene encodes a protein with two C2H2 zinc finger motifs and a score-and-three (23)-amino acid peptide repeat

(STPR) domain. The STPR domain of the encoded protein binds to double stranded DNA and may also contain a nuclear

localization signal, suggesting that this protein interacts with chromosomal DNA. Alternatively spliced transcript

variants encoding multiple isoforms have been observed for this gene. (provided by RefSeq, Jan 2011)

UniProtKB/Swiss-Prot: ZN821_HUMAN, O75541

Function: May be involved in transcriptional regulation

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000016.9 NC_018927.1 NT_010498.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ZNF821 gene promoter:
AML1a p53 RREB-1 POU3F2 C/EBPalpha AREB6 CHOP-10 HSF2 IRF-7A RSRFC4
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ZNF821 promoter sequence

Search SABiosciences Chromatin IP Primers for ZNF821

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF821

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q22.2 Ensembl cytogenetic band: 16q22.2 HGNC cytogenetic band: 16q22.3

ZNF821 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF821 gene location

GeneLoc information about chromosome 16 GeneLoc Exon Structure

GeneLoc location for GC16M071893: view genomic region (about GC identifiers)

Start:	71,893,583 bp from pter	End:	71,929,239 bp from pter
Size:	35,657 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ZN821_HUMAN, O75541 (See protein sequence)

Recommended Name: Zinc finger protein 821

Size: 412 amino acids; 46794 Da

Subcellular location: Nucleus (Probable)

Secondary accessions: A6NK48 B4DKK4 D3DWS3

Alternative splicing: 2 isoforms: O75541-1 O75541-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ZNF821: NX_O75541

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O75541

ZNF821 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (5 alternative transcripts):

NP_001188481.1 NP_001188482.1 NP_001188483.1 NP_001188485.1 NP_060000.1

ENSEMBL proteins:

ENSP00000457396 ENSP00000457985 ENSP00000405908 ENSP00000455738 ENSP00000455648

ENSP00000455454 ENSP00000456563 ENSP00000456087 ENSP00000456193 ENSP00000458112

ENSP00000456031 ENSP00000457202 ENSP00000456106 ENSP00000457068 ENSP00000398089

ENSP00000313822

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	Uscn Proteins for ZNF821

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	--	--
GO:0005634	nucleus	IEA	--

ZNF821 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for ZNF821

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ZNF821 for domains About GeneDecksing

3 InterPro domains/families:

IPR015880 Znf_C2H2-like

IPR013087 Znf_C2H2/integrase_DNA-bd

IPR007087 Znf_C2H2

Graphical View of Domain Structure for InterPro Entry O75541

ProtoNet protein and cluster: O75541

1 Blocks protein family: IPB007086 C2H2-type zinc finger signature

UniProtKB/Swiss-Prot: ZN821_HUMAN, O75541

Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family

Similarity: Contains 2 C2H2-type zinc fingers

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: ZN821_HUMAN, O75541

Function: May be involved in transcriptional regulation

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In Situ Assay
Products:

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Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003676	nucleic acid binding	--	--
GO:0003677	DNA binding	IEA	--
GO:0008270	zinc ion binding	IEA	--

ZNF821 for ontologies About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for ZNF821

STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

2 Interacting proteins for ZNF821 (O75541^{2, 3} ENSP00000313822⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CCDC85B	Q15834²^,³, ENSP00000311695⁴	MINT-66114 I2D: score=5 STRING: ENSP00000311695
LURAP1	Q96LR2³, ENSP00000361048⁴	I2D: score=3 STRING: ENSP00000361048

About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006351	transcription, DNA-dependent	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	IEA	--

ZNF821 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ZNF821
Search CenterWatch for drugs/clinical trials and news about ZNF821 / ZN821

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ZNF821 gene (5 alternative transcripts):

NM_001201552.1 NM_001201553.1 NM_001201554.1 NM_001201556.1 NM_017530.2

Unigene Cluster for ZNF821:

Zinc finger protein 821

Hs.744055 [show with all ESTs]

Unigene Representative Sequence: NM_001201552

18/20 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 20):

ENST00000568961(uc002fbg.4) ENST00000566987(uc002fbe.3) ENST00000446827(uc002fbf.3)

ENST00000564134 ENST00000565601(uc010vmj.2) ENST00000562808 ENST00000568666

ENST00000563827 ENST00000565516 ENST00000562797 ENST00000563878 ENST00000562985

ENST00000564943 ENST00000569186 ENST00000565843 ENST00000568322 ENST00000562677

ENST00000561700

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		hsa-miR-577 hsa-miR-32*
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Additional cDNA sequence:

AF070588.1 AK296603.1 AK313693.1 BC004563.2 BC012116.1 BC091492.1 BC106958.1

19 DOTS entries:

DT.100657860 DT.214016 DT.91760848 DT.100787437 DT.75116800 DT.100787438 DT.120688113 DT.120688221

DT.95090924 DT.100787441 DT.120688161 DT.120688205 DT.65288028 DT.91745815 DT.91760851 DT.120688101

DT.91729711 DT.91846874 DT.95090923

24/101 AceView cDNA sequences (see all 101):

CD723155 CB157198 NM_017530 AA364918 CD244270 BF311486 CB155916 BC004563

CR601716 BX283831 AF070588 BC012116 CD557216 BQ614168 BX460597 BQ270829

BM672507 BG337664 BM924142 BM687368 AL038499 AA620843 T06425 CD722992

GeneLoc Exon Structure

5/13 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF821 (see all 13) About this scheme

ExUns:	1	^	2a	·	2b	·	2c	^	3a	·	3b	^	4a	·	4b	^	5	^	6	^	7a	·	7b	·	7c	^	8a	·	8b	^	9	^	10	^	11	^	12a	·	12b	·	12c	·	12d	·	12e	·	12f
SP1:									-		-								-						-				-		-
SP2:									-		-						-		-						-				-						-
SP3:									-		-						-		-						-		-		-
SP4:																									-
SP5:																	-		-						-		-		-

ECgene alternative splicing isoforms for ZNF821

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ZNF821 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAGTTGTGAA

About this image
See ZNF821 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZNF821

SOURCE GeneReport for Unigene cluster: Hs.744055

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for ZNF821 gene from 7/13 species (see all 13) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Zfp821^{1 , 5}	zinc finger protein 821^{1, 5}	89.72(n)¹ 95.63(a)¹		8 (57.21 cM)⁵ 75871¹ NM_001167946.1¹ NP_001161418.1¹ 109705549⁵
chicken (Gallus gallus)	Aves	ZNF821¹	zinc finger protein 821	78.05(n) 83.9(a)		415878 XM_414235.2 XP_414235.1
lizard (Anolis carolinensis)	Reptilia	ZNF821⁶	--	71(a)	1 ↔ 1	GL343483.1(323196-328534)
tropical clawed frog (Xenopus tropicalis)	Amphibia	Str.882²	Transcribed sequence with weak similarity to protein more	76.82(n)		BX725497.1
zebrafish (Danio rerio)	Actinopterygii	LOC571740¹	histone-lysine N-methyltransferase PRDM9-like	59.6(n) 61.02(a)		571740 XM_695359.4 XP_700451.4
fruit fly (Drosophila melanogaster)	Insecta	CG14442⁶ CG14440⁶	--	6(a) 16(a)	many → 1 many → 1	X(6583329-6589034) X(6589896-6592600)
worm (Caenorhabditis elegans)	Secernentea	C05D11.13⁶	Uncharacterized protein C05D11.13	18(a)	1 ↔ 1	III(6443023-6443919)

ENSEMBL Gene Tree for ZNF821 (if available)
TreeFam Gene Tree for ZNF821 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ZNF821 gene

RREB1²

5 SIMAP similar genes for ZNF821 using alignment to 9 protein entries: ZN821_HUMAN (see all proteins):

LOC55565 ZNF55 ZNF410 RREB1 kr-znf3

ZNF821 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 16 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs7188885^1,2	C,F,H,	--	71893178(+)	`GCTGAC/TTACTG`	6	--	int¹ ds500¹		20		NA NS EA WA	1882
rs138185149^1,2		--	71893209(+)	`ACAATA/GTTGCT`	6	--	ds500¹ int¹		0	--	--	--	--
rs183463492^1,2		--	71893343(+)	`TATCTA/TCATTA`	6	--	int¹ ds500¹		0	--	--	--	--
rs4788566^1,2	C,F,H,	--	71893470(+)	`GAGCAC/TCCTCC`	6	--	int¹ ds500¹		20		NA EA NS WA CSA	758
rs4788567^1,2	C,F,A,H,	--	71893498(+)	`CACCAG/AAAGCC`	6	--	ds500¹ int¹		28		NA NS EA WA	2852
rs149171474^1,2		--	71893782(+)	`CTCAGA/GTCCAC`	6	--	int¹ ut3¹		0	--	--	--	--
rs199747175^1,2		--	71893877(+)	`GGGTGA/GGTGGG`	6	--	int¹ ut3¹		0	--	--	--	--
rs17850869^1,2	C,F,	--	71893981(+)	`CTGTCC/TAACTC`	10	L	syn¹ ut3¹ int¹		3		NA EU	5993
rs201027678^1,2		--	71894002(+)	`ACAGGC/TAGCTG`	10	L	int¹ syn¹ ut3¹		0	--	--	--	--
rs200621442^1,2	C,	--	71894055(+)	`GTCCTC/GGCCAA`	10	Q E	int¹ mis¹ ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for ZNF821 (71893583 - 71929239 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ZNF821: --

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ZNF821 for disorders About MalaCards

ZNF821 for disorders About GeneDecksing

Human Genome Epidemiology (HuGE) Navigator: ZNF821 (1 document)

Export disorders for ZNF821 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ZNF821 gene, integrated from 9 sources (see all 12):
(articles sorted by number of sources associating them with ZNF821)

Utopia: connect your pdf to the dynamic
world of online information

Large-scale concatenation cDNA sequencing. (PubMed id 9110174)^{1, 3} Yu W.... Gibbs R.A. (1997)
A "double adaptor" method for improved shotgun library construction. (PubMed id 8619474)^{1, 3} Andersson B.... Gibbs R.A. (1996)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)¹ Rose J.E....Uhl G.R. (2010)
STPR, a 23-amino acid tandem repeat domain, found in the human function-unknown protein ZNF821. (PubMed id 20795678)¹ Nonaka Y....Kawano K. (2010)
hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)¹ Lamesch P.... Vidal M. (2007)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)¹ Kimura K.... Sugano S. (2006)
Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)¹ Rual J.F....Vidal M. (2005)
The sequence and analysis of duplication-rich human chromosome 16. (PubMed id 15616553)² Martin J.... Pennacchio L.A. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)² Ota T.... Sugano S. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 55565	HGNC: 28043	AceView: LOC55565	Ensembl:ENSG00000102984	euGenes: HUgn55565
ECgene: ZNF821	H-InvDB: ZNF821

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for ZNF821	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ZNF821 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for ZNF821 gene:
Search GeneIP for patents involving ZNF821

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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zinc finger protein 821

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zinc finger protein 821

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