Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ZNF821 Gene

Aliases for ZNF821 Gene

  • Zinc Finger Protein 821 2 3 5

External Ids for ZNF821 Gene

Previous GeneCards Identifiers for ZNF821 Gene

  • GC16M070452
  • GC16M057661

Summaries for ZNF821 Gene

Entrez Gene Summary for ZNF821 Gene

  • This gene encodes a protein with two C2H2 zinc finger motifs and a score-and-three (23)-amino acid peptide repeat (STPR) domain. The STPR domain of the encoded protein binds to double stranded DNA and may also contain a nuclear localization signal, suggesting that this protein interacts with chromosomal DNA. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]

GeneCards Summary for ZNF821 Gene

ZNF821 (Zinc Finger Protein 821) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding.

UniProtKB/Swiss-Prot for ZNF821 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF821 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF821 Gene

Genomics for ZNF821 Gene

GeneHancer (GH) Regulatory Elements for ZNF821 Gene

Promoters and enhancers for ZNF821 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16I071893 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE 550.8 -0.3 -312 3.8 MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NFYC IST1 PIR43283 PIR45337 ZNF821 PHLPP2 HYDIN ENSG00000247324 ZNF19 MARVELD3 DHX38
GH16I071880 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE 550.4 +12.2 12184 4.7 HDGF FOXA2 ARNT ZFP64 SIN3A FEZF1 ZNF2 IRF4 YY1 ZNF766 ENSG00000261765 ZNF821 MARVELD3 IST1 HPR PHLPP2 ENSG00000247324 PIR43283 ATXN1L
GH16I071841 Enhancer 1 FANTOM5 ENCODE 3.2 +52.2 52221 2.4 HDGF PKNOX1 CHD4 PAX8 BATF IRF4 ZBTB40 RELA NFATC1 ATF7 PHLPP2 IST1 ZNF23 ZNF821 DHX38 ATXN1L LOC100420489
GH16I071870 Enhancer 0.4 FANTOM5 4 +24.9 24903 0.1 PRDM10 ATXN1L IST1 ZNF821 PHLPP2 PIR47406 ENSG00000261765
GH16I071890 Enhancer 0.7 ENCODE 0.8 +4.7 4663 0.2 PKNOX1 ATF1 TAF9B SAP130 CHD4 SIN3A CEBPG ZNF384 ZBTB40 ZSCAN9 PIR43283 ZNF821 ENSG00000261765 IST1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF821 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF821 gene promoter:

Genomic Locations for ZNF821 Gene

Genomic Locations for ZNF821 Gene
chr16:71,859,680-71,895,336
(GRCh38/hg38)
Size:
35,657 bases
Orientation:
Minus strand
chr16:71,893,583-71,929,239
(GRCh37/hg19)

Genomic View for ZNF821 Gene

Genes around ZNF821 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF821 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF821 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF821 Gene

Proteins for ZNF821 Gene

  • Protein details for ZNF821 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75541-ZN821_HUMAN
    Recommended name:
    Zinc finger protein 821
    Protein Accession:
    O75541
    Secondary Accessions:
    • A6NK48
    • B4DKK4
    • D3DWS3

    Protein attributes for ZNF821 Gene

    Size:
    412 amino acids
    Molecular mass:
    46794 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF821 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF821 Gene

Post-translational modifications for ZNF821 Gene

No Post-translational modifications

No data available for DME Specific Peptides for ZNF821 Gene

Domains & Families for ZNF821 Gene

Gene Families for ZNF821 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ZNF821 Gene

Suggested Antigen Peptide Sequences for ZNF821 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O75541

UniProtKB/Swiss-Prot:

ZN821_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF821: view

Function for ZNF821 Gene

Molecular function for ZNF821 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF821 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 DNA binding transcription factor activity IBA --
GO:0005515 protein binding IPI 25416956
GO:0044212 transcription regulatory region DNA binding IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF821: view

Phenotypes for ZNF821 Gene

genes like me logo Genes that share phenotypes with ZNF821: view

miRNA for ZNF821 Gene

miRTarBase miRNAs that target ZNF821

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF821 Gene

Localization for ZNF821 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF821 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF821 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear speckles (3)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF821 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF821: view

Pathways & Interactions for ZNF821 Gene

SuperPathways for ZNF821 Gene

No Data Available

Interacting Proteins for ZNF821 Gene

Gene Ontology (GO) - Biological Process for ZNF821 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0045944 positive regulation of transcription by RNA polymerase II IBA --
genes like me logo Genes that share ontologies with ZNF821: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF821 Gene

Drugs & Compounds for ZNF821 Gene

No Compound Related Data Available

Transcripts for ZNF821 Gene

Unigene Clusters for ZNF821 Gene

Zinc finger protein 821:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF821 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c · 12d · 12e · 12f
SP1: - - - - - -
SP2: - - - - - - -
SP3: - - - - - - -
SP4: -
SP5: - - - - -
SP6: - - - - -
SP7: - - - -
SP8: - - - -
SP9: - - - -
SP10: - -
SP11: - - - - - - - -
SP12: - - - -
SP13: - - - -

Relevant External Links for ZNF821 Gene

GeneLoc Exon Structure for
ZNF821
ECgene alternative splicing isoforms for
ZNF821

Expression for ZNF821 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF821 Gene

mRNA differential expression in normal tissues according to GTEx for ZNF821 Gene

This gene is overexpressed in Testis (x4.2) and Brain - Cerebellar Hemisphere (x4.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF821 Gene



Protein tissue co-expression partners for ZNF821 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF821 Gene:

ZNF821

SOURCE GeneReport for Unigene cluster for ZNF821 Gene:

Hs.744055

Evidence on tissue expression from TISSUES for ZNF821 Gene

  • Nervous system(4.6)
  • Intestine(4.1)
genes like me logo Genes that share expression patterns with ZNF821: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF821 Gene

Orthologs for ZNF821 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF821 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF821 33 34
  • 99.27 (n)
dog
(Canis familiaris)
Mammalia ZNF821 33 34
  • 94.26 (n)
cow
(Bos Taurus)
Mammalia ZNF821 33 34
  • 93.77 (n)
oppossum
(Monodelphis domestica)
Mammalia ZNF821 34
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZNF821 34
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp821 33 16 34
  • 89.72 (n)
chicken
(Gallus gallus)
Aves ZNF821 33 34
  • 77.67 (n)
lizard
(Anolis carolinensis)
Reptilia ZNF821 34
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia znf821 33
  • 67.43 (n)
Str.882 33
zebrafish
(Danio rerio)
Actinopterygii LOC571740 33
  • 57.85 (n)
CABZ01083862.1 34
  • 50 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta peb 34
  • 4 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 12 (a)
OneToOne
Species where no ortholog for ZNF821 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF821 Gene

ENSEMBL:
Gene Tree for ZNF821 (if available)
TreeFam:
Gene Tree for ZNF821 (if available)

Paralogs for ZNF821 Gene

(3) SIMAP similar genes for ZNF821 Gene using alignment to 9 proteins:

genes like me logo Genes that share paralogs with ZNF821: view

No data available for Paralogs for ZNF821 Gene

Variants for ZNF821 Gene

Sequence variations from dbSNP and Humsavar for ZNF821 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000083044 -- 71,860,637(-) A/T 3_prime_UTR_variant, coding_sequence_variant, missense_variant
rs1000283993 -- 71,884,083(-) C/T 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000373897 -- 71,861,543(-) T/C intron_variant
rs1000448127 -- 71,862,082(-) AAAA/AAA intron_variant
rs1000649436 -- 71,884,858(-) T/G 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF821 Gene

Variant ID Type Subtype PubMed ID
esv1001782 CNV insertion 20482838
esv3303504 CNV mobile element insertion 20981092
esv3431278 CNV insertion 20981092
nsv7285 OTHER inversion 18451855

Variation tolerance for ZNF821 Gene

Residual Variation Intolerance Score: 44.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.54; 11.74% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF821 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF821

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF821 Gene

Disorders for ZNF821 Gene

Additional Disease Information for ZNF821

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for ZNF821 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF821 Gene

Publications for ZNF821 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  2. Large-scale concatenation cDNA sequencing. (PMID: 9110174) Yu W … Gibbs RA (Genome research 1997) 2 3 58
  3. A "double adaptor" method for improved shotgun library construction. (PMID: 8619474) Andersson B … Gibbs RA (Analytical biochemistry 1996) 2 3 58
  4. Systematic identification of molecular links between core and candidate genes in breast cancer. (PMID: 25640309) Arroyo R … Aloy P (Journal of molecular biology 2015) 3 58
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58

Products for ZNF821 Gene

Sources for ZNF821 Gene

Content
Loading form....