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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ZNF816 Gene

protein-coding GIFtS: 43
GCID: GC19M053453

zinc finger protein 816

(Previous name: zinc finger protein 816A )
(Previous symbol: ZNF816A)

Explore 1 disease affiliated with
ZNF816 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Zinc Finger Protein 816¹ ²
ZNF816A¹ ² ³
Zinc Finger Protein 816A¹ ²

External Ids:	HGNC: 26995¹	Entrez Gene: 125893²	Ensembl: ENSG00000180257⁷	UniProtKB: Q0VGE8³

Export aliases for ZNF816 gene to outside databases

Previous GC identifer: GC19M049780

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: ZN816_HUMAN, Q0VGE8

Function: May be involved in transcriptional regulation

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000019.9 NC_018930.1 NT_011109.16

Regulatory elements:

Search SABiosciences Regulatory transcription factor binding sites for ZNF816
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ZNF816 promoter sequence

Search SABiosciences Chromatin IP Primers for ZNF816

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF816

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.41 Ensembl cytogenetic band: 19q13.41 HGNC cytogenetic band: 19q13.41

ZNF816 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF816 gene location

GeneLoc information about chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19M053453: view genomic region (about GC identifiers)

Start:	53,430,388 bp from pter	End:	53,466,164 bp from pter
Size:	35,777 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ZN816_HUMAN, Q0VGE8 (See protein sequence)

Recommended Name: Zinc finger protein 816

Size: 651 amino acids; 75725 Da

Subcellular location: Nucleus (Probable)

Secondary accessions: A8K7H5 Q3KR39 Q659B3

Explore the universe of human proteins at neXtProt for ZNF816: NX_Q0VGE8

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q0VGE8

ZNF816 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_001026835.1 NP_001189385.1 NP_001189386.1

ENSEMBL proteins:

ENSP00000350295 ENSP00000403266 ENSP00000408965 ENSP00000333199 ENSP00000438519

ENSP00000449832

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Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	--	--
GO:0005634	nucleus	IEA	--

ZNF816 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ZNF816 for domains About GeneDecksing

4 InterPro domains/families:

IPR015880 Znf_C2H2-like

IPR001909 Krueppel-associated_box

IPR013087 Znf_C2H2/integrase_DNA-bd

IPR007087 Znf_C2H2

Graphical View of Domain Structure for InterPro Entry Q0VGE8

ProtoNet protein and cluster: Q0VGE8

1 Blocks protein family: IPB001909 KRAB box

UniProtKB/Swiss-Prot: ZN816_HUMAN, Q0VGE8

Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family

Similarity: Contains 15 C2H2-type zinc fingers

Similarity: Contains 1 KRAB domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: ZN816_HUMAN, Q0VGE8

Function: May be involved in transcriptional regulation

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Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003676	nucleic acid binding	--	--
GO:0003677	DNA binding	IEA	--
GO:0008270	zinc ion binding	IEA	--

ZNF816 for ontologies About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for ZNF816

2 Interacting proteins for ZNF816 (Q0VGE8³) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
DVL2	O14641³	I2D: score=1
DVL3	Q92997³	I2D: score=1

About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006351	transcription, DNA-dependent	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	IEA	--

ZNF816 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ZNF816
Search CenterWatch for drugs/clinical trials and news about ZNF816 / ZN816

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ZNF816 gene (3 alternative transcripts):

NM_001031665.2 NM_001202456.1 NM_001202457.1

Unigene Cluster for ZNF816:

Zinc finger protein 816

Hs.655592 [show with all ESTs]

Unigene Representative Sequence: NM_001031665

10 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000357666(uc002qal.2 uc021uzc.1 uc002qam.2) ENST00000444460

ENST00000391786 ENST00000457013 ENST00000438970 ENST00000270457 ENST00000535506

ENST00000332302 ENST00000434371 ENST00000549216(uc002qaj.1 uc010eqj.3 uc002qak.2)

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Additional cDNA sequence:

AK291990.1 AL713804.1 BC063805.1 BC105739.1 BC105740.1 BC105930.1

10 DOTS entries:

DT.121461929 DT.100754087 DT.102839353 DT.121462326 DT.100797473 DT.86837062 DT.97774348 DT.121462164

DT.40290520 DT.91758862

21 AceView cDNA sequences:

AI085627 AA316179 BU507748 BF890741 NM_203307 CR749224 BC046449 AW516097

BE466270 AK096828 BX479857 BU902042 AI821548 BX097745 BQ007859 BC063805

AA421607 CF135044 AW580473 AI559335 BE832369

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ZNF816 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CAGAACATCA

About this image
See ZNF816 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZNF816

SOURCE GeneReport for Unigene cluster: Hs.655592

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

--

ENSEMBL Gene Tree for ZNF816 (if available)
TreeFam Gene Tree for ZNF816 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ZNF816 gene

ZNF534² ZNF321P² ZNF468² ZNF578² ZNF880² ZNF766² ZNF320² ZNF525²

ZNF860² ZNF415² ZNF600² ZNF28² ZNF528² ZNF611² ZNF677² ZNF83²

ZNF610² ZNF701² ZNF765² ZNF480² ZNF813²

18/507 SIMAP similar genes for ZNF816 using alignment to 6 protein entries: ZN816_HUMAN (see all proteins) (see all similar genes):

kr-znf3 MGC12518 ZNF78L1 ZNF761 ZNF28 ZNF321P

ZNF525 ZNF702P ZNF195 ZNF808 ZFS-5 ZNF670

ZNF578 DKFZp686M04222 ZFS-6 ZNF726 ZNF624 APOPT1

ZNF816 for paralogs About GeneDecksing

3 Pseudogenes.org Pseudogenes for ZNF816
PGOHUM00000250842 PGOHUM00000259421 PGOHUM00000259946

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs182446695^1,2		--	53452133(+)	`TTGCAA/GTGAGC`	4	--	int¹		0	--	--	--	--
rs187904855^1,2		--	53452166(+)	`AGCCTA/GGGTGA`	4	--	int¹		0	--	--	--	--
rs192417868^1,2		--	53452226(+)	`TAAATA/CAAAAT`	4	--	int¹		0	--	--	--	--
rs148433185^1,2		--	53452246(+)	`AGCATA/GGTGTG`	4	--	int¹		0	--	--	--	--
rs145524339^1,2		--	53452284(+)	`TCAGGA/GGGCTG`	4	--	int¹		0	--	--	--	--
rs184511435^1,2		--	53452377(+)	`GAGCAA/GGACTC`	4	--	int¹		0	--	--	--	--
rs111541336^1,2	C,	--	53452475(+)	`ATCTACCTG/- CCTGC`	4	--	int¹		1		CSA	2
rs56113757^1,2	C	--	53452482(+)	`TGCCT-/GCCT TGGCC`	4	--	int¹		0	--	--	--	--
rs8105805^1,2	A	--	53452511(+)	`acaggC/Tatgag`	4	--	int¹		0	--	--	--	--
rs147713568^1,2		--	53452644(+)	`TTTATC/GATTTT`	4	--	int¹ ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for ZNF816 (53430388 - 53466164 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ZNF816: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ZNF816 for disorders About GeneDecksing

1 disease for ZNF816: About MalaCards

psoriasis

Human Genome Epidemiology (HuGE) Navigator: ZNF816 (1 document)

Export disorders for ZNF816 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ZNF816 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ZNF816)

Utopia: connect your pdf to the dynamic
world of online information

Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)¹ Udeshi N.D....Carr S.A. (2012)
Association analyses identify six new psoriasis susce ptibility loci in the Chinese population. (PubMed id 20953187)¹ Sun L.D....Zhang X.J. (2010)
The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)² Bechtel S.... Schupp I. (2007)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)¹ Kimura K.... Sugano S. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)² Ota T.... Sugano S. (2004)
The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)² Grimwood J.... Lucas S.M. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 125893	HGNC: 26995	AceView: MGC35402	Ensembl:ENSG00000180257	euGenes: HUgn125893
ECgene: ZNF816	H-InvDB: ZNF816

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ZNF816	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ZNF816 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for ZNF816 gene:
Search GeneIP for patents involving ZNF816

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
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About This Section


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GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
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The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes ZNF816 gene at Home site.

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ZNF816 Gene

zinc finger protein 816

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ZNF816 Gene

zinc finger protein 816

Aliasesfor ZNF816 gene

Summariesfor ZNF816 gene

Genomic Viewsfor ZNF816 gene

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Protein Domains /Familiesfor ZNF816 gene

Functionfor ZNF816 gene

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for ZNF816 gene

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for ZNF816 gene

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for ZNF816 gene

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for ZNF816 gene

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for ZNF816 gene

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for ZNF816 gene

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for ZNF816 gene

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for ZNF816 gene

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for ZNF816 gene

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for ZNF816 gene

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for ZNF816 gene

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