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Aliases for ZNF816 Gene

Aliases for ZNF816 Gene

  • Zinc Finger Protein 816 2 3 5
  • Zinc Finger Protein 816A 2 3
  • ZNF816A 3 4

External Ids for ZNF816 Gene

Previous HGNC Symbols for ZNF816 Gene

  • ZNF816A

Previous GeneCards Identifiers for ZNF816 Gene

  • GC19M053453
  • GC19M049780

Summaries for ZNF816 Gene

GeneCards Summary for ZNF816 Gene

ZNF816 (Zinc Finger Protein 816) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZNF611.

UniProtKB/Swiss-Prot for ZNF816 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF816 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF816 Gene

Genomics for ZNF816 Gene

Regulatory Elements for ZNF816 Gene

Enhancers for ZNF816 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19H052941 1.9 FANTOM5 Ensembl ENCODE dbSUPER 36.5 +18.4 18419 6.1 HDGF PKNOX1 ATF1 FOXA2 MLX ARID4B DMAP1 ETS1 GLIS2 ATF7 ZNF816 ZNF160 VN1R2 ZNF677 ZNF665 ZNF761 ZNF347 ZNF415 ZNF83 ZNF701
GH19H052137 1.4 FANTOM5 ENCODE 40.3 +823.3 823280 3.3 PKNOX1 FOXA2 ARNT ARID4B SIN3A DMAP1 YY1 ZNF143 SP3 SP5 ZNF137P ZNF160 ZNF808 ENSG00000268970 ZNF600 ZNF350 ZNF816 ZNF836 ZNF577 ZNF841
GH19H053864 1.8 FANTOM5 ENCODE dbSUPER 17.8 -906.0 -906004 9.8 HDGF FOXA2 MLX ZFP64 ARID4B SIN3A DMAP1 ZBTB7B SLC30A9 FOS ENSG00000269001 ZNF845 ZNF765 ZNF816 LENG8 ENSG00000235681 ZNF813 TPM3P6 ZNF160 LENG8-AS1
GH19H052961 1 ENCODE 30.6 +0.2 201 2.4 HDGF ATF1 ARID4B DMAP1 ETS1 GLIS2 ELK1 ZNF143 ATF7 SP3 ZNF816 ZNF137P ZNF665 ENSG00000268970 ZNF701 ZNF611 ENSG00000269001 TPM3P9 ZNF525 ZNF160
GH19H052733 1.4 FANTOM5 ENCODE 11.8 +227.6 227642 2.8 HDGF ARID4B SIN3A ELK1 ATF7 SP3 SP5 REST ZNF518A ZNF592 ZNF611 ZNF613 ZNF137P ENSG00000268970 ZNF701 ENSG00000269001 TPM3P9 ZNF525 ZNF665 TPM3P6
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF816 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF816 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000111337 310 2400 ATF1 ARID4B DMAP1 GLIS2 ELK1 ZNF143 ATF7 SP3 SP5 MXD4

Genomic Locations for ZNF816 Gene

Genomic Locations for ZNF816 Gene
13,533 bases
Minus strand

Genomic View for ZNF816 Gene

Genes around ZNF816 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF816 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF816 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF816 Gene

Proteins for ZNF816 Gene

  • Protein details for ZNF816 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 816
    Protein Accession:
    Secondary Accessions:
    • A8K7H5
    • Q3KR39
    • Q659B3

    Protein attributes for ZNF816 Gene

    651 amino acids
    Molecular mass:
    75725 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF816 Gene

Post-translational modifications for ZNF816 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF816 Gene

Domains & Families for ZNF816 Gene

Gene Families for ZNF816 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Transcription factors

Protein Domains for ZNF816 Gene

Suggested Antigen Peptide Sequences for ZNF816 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF816: view

Function for ZNF816 Gene

Molecular function for ZNF816 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF816 Gene

Gene Ontology (GO) - Molecular Function for ZNF816 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF816: view

Phenotypes for ZNF816 Gene

GenomeRNAi human phenotypes for ZNF816:
genes like me logo Genes that share phenotypes with ZNF816: view

Animal Model Products

miRNA for ZNF816 Gene

miRTarBase miRNAs that target ZNF816

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF816 Gene

Localization for ZNF816 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF816 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF816 gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF816 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ZNF816: view

Pathways & Interactions for ZNF816 Gene

SuperPathways for ZNF816 Gene

No Data Available

Interacting Proteins for ZNF816 Gene

Gene Ontology (GO) - Biological Process for ZNF816 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA,IEA --
genes like me logo Genes that share ontologies with ZNF816: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF816 Gene

Drugs & Compounds for ZNF816 Gene

(1) Drugs for ZNF816 Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Tumor necrosis factor alpha (TNF-alpha) inhibitors Pharma 0
genes like me logo Genes that share compounds with ZNF816: view

Transcripts for ZNF816 Gene

Unigene Clusters for ZNF816 Gene

Zinc finger protein 816:
Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF816 Gene

No ASD Table

Relevant External Links for ZNF816 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF816 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF816 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of ZNF816 Gene:


SOURCE GeneReport for Unigene cluster for ZNF816 Gene:


Evidence on tissue expression from TISSUES for ZNF816 Gene

  • Intestine(4.5)
  • Lung(3.6)
  • Nervous system(3.6)
  • Skin(3.3)
  • Bone(2.2)
genes like me logo Genes that share expression patterns with ZNF816: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF816 Gene

Orthologs for ZNF816 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF816 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC748668 33
  • 98.72 (n)
ZNF816 34
  • 49 (a)
(Rattus norvegicus)
Mammalia Zfp141 33
  • 65.66 (n)
(Canis familiaris)
Mammalia -- 34
  • 52 (a)
(Bos Taurus)
Mammalia -- 34
  • 44 (a)
Species where no ortholog for ZNF816 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF816 Gene

Gene Tree for ZNF816 (if available)
Gene Tree for ZNF816 (if available)

Paralogs for ZNF816 Gene

(516) SIMAP similar genes for ZNF816 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with ZNF816: view

Variants for ZNF816 Gene

Sequence variations from dbSNP and Humsavar for ZNF816 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000116311 -- 52,962,827(+) CTAGG(A/C)AACGC utr-variant-5-prime
rs1000146635 -- 52,964,620(+) CAGTG(G/T)TGGGA upstream-variant-2KB
rs1000212551 -- 52,963,192(+) AGTTC(C/T)TTGCT upstream-variant-2KB
rs1000453405 -- 52,963,899(+) GAAAG(A/G)AGGGG upstream-variant-2KB
rs1000677415 -- 52,958,550(+) AGTAC(A/G)TTGAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF816 Gene

Variant ID Type Subtype PubMed ID
nsv963071 CNV duplication 23825009
nsv580030 CNV gain 21841781
nsv428370 CNV loss 18775914
nsv1140479 CNV deletion 24896259
nsv1127696 CNV deletion 24896259
nsv1078889 OTHER inversion 25765185
nsv1066762 CNV gain 25217958
nsv1064234 CNV gain 25217958
nsv1057118 CNV gain 25217958
esv2758769 CNV loss 17122850
esv2718808 CNV deletion 23290073
esv2718799 CNV deletion 23290073
esv2718796 CNV deletion 23290073
esv2718787 CNV deletion 23290073
esv2718786 CNV deletion 23290073

Variation tolerance for ZNF816 Gene

Residual Variation Intolerance Score: 98.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.29; 94.10% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF816 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF816 Gene

Disorders for ZNF816 Gene

Relevant External Links for ZNF816

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZNF816 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF816 Gene

Publications for ZNF816 Gene

  1. Association analyses identify six new psoriasis susceptibility loci in the Chinese population. (PMID: 20953187) Sun LD … Zhang XJ (Nature genetics 2010) 3 45 60
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  3. The full-ORF clone resource of the German cDNA Consortium. (PMID: 17974005) Bechtel S … Schupp I (BMC genomics 2007) 4 60
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 60
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 4 60

Products for ZNF816 Gene

Sources for ZNF816 Gene

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