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ZNF816 Gene

protein-coding   GIFtS: 46
GCID: GC19M053453

Zinc Finger Protein 816

(Previous name: zinc finger protein 816A)
(Previous symbol: ZNF816A)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger Protein 8161 2
ZNF816A1 2 3
Zinc Finger Protein 816A1 2

External Ids:    HGNC: 269951   Entrez Gene: 1258932   Ensembl: ENSG000001802577   UniProtKB: Q0VGE83   

Export aliases for ZNF816 gene to outside databases

Previous GC identifer: GC19M049780


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZNF816 Gene:
ZNF816 (zinc finger protein 816) is a protein-coding gene. An important paralog of this gene is ZNF534.

UniProtKB/Swiss-Prot: ZN816_HUMAN, Q0VGE8
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NC_018930.2  NT_011109.17  
Regulatory elements:
   Search for regulatory transcription factor binding sites for ZNF816
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF816 promoter sequence
   Search Chromatin IP Primers for ZNF816

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF816


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.41   Ensembl cytogenetic band:  19q13.41   HGNC cytogenetic band: 19q13.41

ZNF816 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF816 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M053453:  view genomic region     (about GC identifiers)

Start:
53,430,388 bp from pter      End:
53,466,164 bp from pter
Size:
35,777 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ZN816_HUMAN, Q0VGE8 (See protein sequence)
Recommended Name: Zinc finger protein 816  
Size: 651 amino acids; 75725 Da
Secondary accessions: A8K7H5 Q3KR39 Q659B3

Explore the universe of human proteins at neXtProt for ZNF816: NX_Q0VGE8

Explore proteomics data for ZNF816 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ZNF816 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001026835.1  NP_001189385.1  NP_001189386.1  

    ENSEMBL proteins: 
     ENSP00000350295   ENSP00000403266   ENSP00000471215   ENSP00000408965   ENSP00000469688  
     ENSP00000472475   ENSP00000470838   ENSP00000333199   ENSP00000438519   ENSP00000449832  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR001909 Krueppel-associated_box
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q0VGE8

    ProtoNet protein and cluster: Q0VGE8

    1 Blocks protein domain: IPB001909 KRAB box

    UniProtKB/Swiss-Prot: ZN816_HUMAN, Q0VGE8
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 15 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    Find genes that share domains with ZNF816           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN816_HUMAN, Q0VGE8
    Function: May be involved in transcriptional regulation

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IBA--
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with ZNF816           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for ZNF816

    miRNA
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    miRTarBase miRNAs that target ZNF816:
    hsa-mir-1301-3p (MIRT035958)

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZN816_HUMAN, Q0VGE8: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--

    Find genes that share ontologies with ZNF816           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF816
    Interactions:

        Search GeneGlobe Interaction Network for ZNF816

    2 Interacting proteins for ZNF816 (Q0VGE83) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DVL2O146413I2D: score=1 
    DVL3Q929973I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IBA--

    Find genes that share ontologies with ZNF816           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZNF816 (ZN816)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ZNF816 gene (3 alternative transcripts): 
    NM_001031665.2  NM_001202456.1  NM_001202457.1  

    Unigene Cluster for ZNF816:

    Zinc finger protein 816
    Hs.655592  [show with all ESTs]
    Unigene Representative Sequence: NM_001031665
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000357666(uc002qal.2 uc021uzc.1 uc002qam.2) ENST00000444460
    ENST00000391786 ENST00000457013 ENST00000438970 ENST00000270457 ENST00000535506
    ENST00000332302 ENST00000434371 ENST00000549216(uc002qaj.1 uc010eqj.3 uc002qak.2)

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    Additional mRNA sequence: 

    AK291990.1 AL713804.1 BC063805.1 BC105739.1 BC105740.1 BC105930.1 

    10 DOTS entries:

    DT.121461929  DT.100754087  DT.102839353  DT.121462326  DT.100797473  DT.86837062  DT.97774348  DT.121462164 
    DT.40290520  DT.91758862 

    21 AceView cDNA sequences:

    BU507748 AA316179 AI085627 CR749224 AW516097 BU902042 NM_203307 AA421607 
    BC046449 BX479857 BQ007859 AI821548 BE466270 BX097745 BF890741 BC063805 
    AK096828 AI559335 AW580473 CF135044 BE832369 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZNF816 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAGAACATCA
    ZNF816 Expression
    About this image


    ZNF816 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Heart (Cardiovascular System)
             Atrioventricular Node
     
     Ovary (Reproductive System)
    ZNF816 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZNF816 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.655592
        Custom PCR Arrays for ZNF816
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF816

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for ZNF816 gene from Selected species (see all 4)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    rat
    (Rattus norvegicus)
    Mammalia Zfp1411 zinc finger protein 141 65.66(n)
    54.33(a)
      690343  XM_006228939.1  XP_006229001.1 


    ENSEMBL Gene Tree for ZNF816 (if available)
    TreeFam Gene Tree for ZNF816 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZNF816 gene
    ZNF5342  ZNF321P2  ZNF4682  ZNF5782  ZNF8802  ZNF7662  ZNF3202  ZNF5252  
    ZNF8602  ZNF4152  ZNF6002  ZNF282  ZNF5282  ZNF6112  ZNF6772  ZNF832  
    ZNF6102  ZNF7012  ZNF7652  ZNF4802  ZNF8132  
    Selected SIMAP similar genes for ZNF816 using alignment to 6 protein entries:     ZN816_HUMAN (see all proteins) (see all similar genes):
    ZNF525    kr-znf3    ZNF675    ZNF431    ZNF616    ZNF78L1
    ZNF808    ZNF83    MGC12518    ZNF321P    ZNF347    ZNF702P
    ZNF320    ZNF845    ZNF578    ZNF670    ZNF28    ZNF682

    Find genes that share paralogs with ZNF816           About GenesLikeMe


    3 Pseudogenes.org Pseudogenes for ZNF816
    PGOHUM00000250842 PGOHUM00000259421 PGOHUM00000259946


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    2 SNPs for ZNF816    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs124590081,2,4
    ----see VAR_0331652 mis40--------
    rs110842101,2,4
    ----see VAR_0331662 mis40--------

    HapMap Linkage Disequilibrium report for ZNF816 (53430388 - 53466164 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for ZNF816:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2718787CNV Deletion23290073
    esv2718799CNV Deletion23290073
    esv2718796CNV Deletion23290073
    esv2718786CNV Deletion23290073
    esv2718808CNV Deletion23290073
    nsv428370CNV Loss18775914
    dgv3987n71CNV Gain21882294
    dgv1116e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with ZNF816           About GenesLikeMe

    Genetic Association Database (GAD): ZNF816
    Human Genome Epidemiology (HuGE) Navigator: ZNF816 (1 document)

    Export disorders for ZNF816 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZNF816 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with ZNF816)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Association analyses identify six new psoriasis susceptibility loci in the Chinese population. (PubMed id 20953187)1, 4 Sun L.D....Zhang X.J. (Nat. Genet. 2010)
    2. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    3. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    4. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    5. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)
    6. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)
    9. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (Nature 2004)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 125893 HGNC: 26995 AceView: MGC35402 Ensembl:ENSG00000180257 euGenes: HUgn125893
    ECgene: ZNF816 H-InvDB: ZNF816

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZNF816 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZNF816 gene:
    Search GeneIP for patents involving ZNF816

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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