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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZNF814 Gene

protein-coding   GIFtS: 37
GCID: GC19M058361

Zinc Finger Protein 814

  Search for ZNF814
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Zinc Finger Protein 8141 2
Putative Uncharacterized Zinc Finger Protein 8142
Putative Zinc Finger Protein LOC7300513

External Ids:    HGNC: 332581   Entrez Gene: 7300512   Ensembl: ENSG000002045147   UniProtKB: B7Z6K73   

Export aliases for ZNF814 gene to outside databases

Previous GC identifers: GC19U900727 GC19M063072 GC19M058380 GC19M054692


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ZNF814 Gene: 
ZNF814 (zinc finger protein 814) is a protein-coding gene. GO annotations related to this gene include zinc ion binding and nucleic acid binding. An important paralog of this gene is ZNF549.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.2  NT_011109.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZNF814 gene promoter:
         MEF-2A   HFH-3   FOXI1   Nkx6-1   aMEF-2   RSRFC4   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for ZNF814

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF814


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.43   Ensembl cytogenetic band:  19q13.43   HGNC cytogenetic band: 19q13.43

ZNF814 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF814 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M058361:  view genomic region     (about GC identifiers)

Start:
58,360,099 bp from pter      End:
58,400,442 bp from pter
Size:
40,344 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZN814_HUMAN, B7Z6K7 (See protein sequence)
Recommended Name: Putative uncharacterized zinc finger protein 814  
Size: 855 amino acids; 97337 Da
Secondary accessions: A6NF35

Explore the universe of human proteins at neXtProt for ZNF814: NX_B7Z6K7

Explore proteomics data for ZNF814 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_B7Z6K7

  • ZNF814 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ZNF814 Protein Expression
    REFSEQ proteins: NP_001138461.1  
    ENSEMBL proteins: 
     ENSP00000470328   ENSP00000470296   ENSP00000469912   ENSP00000471385   ENSP00000469704  
     ENSP00000471045   ENSP00000472089   ENSP00000470748   ENSP00000410545   ENSP00000469641  

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    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular IEA--

    ZNF814 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR001909 Krueppel-associated_box
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry B7Z6K7

    ProtoNet protein and cluster: B7Z6K7

    UniProtKB/Swiss-Prot: ZN814_HUMAN, B7Z6K7
    Similarity: Contains 23 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    ZNF814 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding IEA--
    GO:0008270zinc ion binding ----
    GO:0046872metal ion binding IEA--
         
    ZNF814 for ontologies           About GeneDecksing


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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF814

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-dependent IEA--

    ZNF814 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
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    Browse Tocris compounds for ZNF814 (ZN814)

    Search CenterWatch for drugs/clinical trials and news about ZNF814 / ZN814

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    About This Section

    REFSEQ mRNAs for ZNF814 gene: 
    NM_001144989.1  

    Unigene Clusters for ZNF814:

    Zinc finger protein 814
    Hs.634143  [show with all ESTs], Hs.733810  [show with all ESTs]
    Unigene Representative Sequences: NM_001144989, AK096401
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000597652 ENST00000596604 ENST00000597342 ENST00000597832 ENST00000595894
    ENST00000595295 ENST00000596184 ENST00000597348 ENST00000600634 ENST00000595048
    ENST00000594629 ENST00000594159 ENST00000435989(uc002qqk.2 uc010yhl.2 uc002qqo.2 uc002qqp.3)
    ENST00000597807
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    Inhib. RNA
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    Additional mRNA sequence: AK096401.1 

    24/29 DOTS entries (see all 29):

    DT.305829  DT.40114240  DT.100773929  DT.40128049  DT.99993016  DT.91671501  DT.91802392  DT.91653802 
    DT.40211539  DT.91749895  DT.100773930  DT.86821299  DT.86853024  DT.95369520  DT.100035962  DT.100685851 
    DT.100730539  DT.100751796  DT.100751797  DT.100773927  DT.102843465  DT.121503633  DT.121503658  DT.86851471 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZNF814 expression in normal human tissues (normalized intensities)      ZNF814 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTACATTCTG
    ZNF814 Expression
    About this image


    ZNF814 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/1 selected tissues (see all 1) fully expand
     
     Brain (Nervous System)
             Medulla Oblongata

    See ZNF814 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZNF814

    SOURCE GeneReport for Unigene clusters: Hs.634143 Hs.733810
        SABiosciences Custom PCR Arrays for ZNF814
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF814

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for ZNF814 gene from 2/6 species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfp9451 , 5 zinc finger protein 9451, 5 54.65(n)1
    42.6(a)1
      17 (11.40 cM)5
    2400411  NM_001110254.11  NP_001103724.11 
     228490305 
    zebrafish
    (Danio rerio)
    Actinopterygii ZNF814 (5 of 7)6
    ZNF814 (4 of 7)6
    (see all 7)
    zinc finger protein 814
    (see all 7)
    41(a)
    39(a)
    (see all 7)
    many → 1
    many → 1
    (see all 7)
    14(37878824-37889835)
    15(890553-899160)


    ENSEMBL Gene Tree for ZNF814 (if available)
    TreeFam Gene Tree for ZNF814 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZNF814 gene
    ZNF5492  ENSG000002695332  ZNF4172  ENSG000002681332  ENSG000002681072  ZNF4162  ZNF172  ZNF5482  
    ZNF587B2  ZNF7732  ZIK12  ZNF1342  ZNF6712  ZNF7722  ZNF5302  ZNF4192  
    ZNF5872  ZNF2112  ZNF7922  ZNF7492  ZNF5512  ENSG000002687502  ZNF7762  ZNF5472  
    ZNF5842  ENSG000002690262  ZNF3042  ZNF1322  ZNF5862  ZNF4182  ZNF2562  ZNF5522  
    ZNF1542  
    18/531 SIMAP similar genes for ZNF814 using alignment to 9 protein entries:     ZN814_HUMAN (see all proteins) (see all similar genes):
    ZNF552    ZNF78L1    ZNF418    ZNF776    ZNF577    ZNF586
    ZNF738    kr-znf3    ZNF649    ZNF417    TCF4    ZNF587B
    ZFS-4    ZNF17    ZNF559    ZNF350    ZNF211    DKFZp666C237

    ZNF814 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/492 SNPs in ZNF814 are shown (see all 492)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0632614
    ----see VAR_0632612 M V mis40--------
    rs1422998021,2
    C--58380291(+) AACTC-/TGTATCT 1 -- ds50010--------
    rs8908671,2
    C,F,A,H--58380337(-) CAAGGT/CTTAAA 1 -- ds500112Minor allele frequency- C:0.47NA WA CSA EA 510
    rs20120341,2
    C,F,A,H--58380385(-) CACCCA/GGCCCA 1 -- ds50017Minor allele frequency- G:0.37NA WA CSA 248
    rs23751601,2
    C,F--58380389(-) accacA/Gcccag 1 -- ds50011Minor allele frequency- G:0.39WA 118
    rs28890081,2
    F--58380391(-) gcaccA/Gcaccc 1 -- ds50011Minor allele frequency- G:0.26EA 120
    rs28890071,2
    C,F--58380396(-) tagagC/Gcacca 1 -- ds50013Minor allele frequency- G:0.17NA WA 6
    rs561460991,2
    --58380430(+) AGGCCA/GAGGCA 1 -- ds50010--------
    rs1911894861,2
    C--58380479(+) TAACAC/TGGTGA 1 -- ds50010--------
    rs1826482341,2
    --58380557(+) TGCTCA/GGGAGG 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for ZNF814 (58360099 - 58400442 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for ZNF814:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2719092CNV Deletion23290073
    esv2719093CNV Deletion23290073
    esv2302097CNV Deletion18987734
    esv1001775CNV Deletion20482838
    nsv912529CNV Loss21882294
    nsv912528CNV Gain21882294
    nsv7311OTHER Inversion18451855

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZNF814 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ZNF814)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 730051 HGNC: 33258 Ensembl:ENSG00000204514 euGenes: HUgn730051 ECgene: ZNF814
    H-InvDB: ZNF814

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZNF814 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZNF814 gene:
    Search GeneIP for patents involving ZNF814

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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