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ZNF814 Gene

protein-coding   GIFtS: 38
GCID: GC19M058361

Zinc Finger Protein 814

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Zinc Finger Protein 8141 2
Putative Uncharacterized Zinc Finger Protein 8142
Putative Zinc Finger Protein LOC7300513

External Ids:    HGNC: 332581   Entrez Gene: 7300512   Ensembl: ENSG000002045147   UniProtKB: B7Z6K73   
ORGUL members:         

Export aliases for ZNF814 gene to outside databases

Previous GC identifers: GC19U900727 GC19M063072 GC19M058380 GC19M054692


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZNF814 Gene:
ZNF814 (zinc finger protein 814) is a protein-coding gene. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF616.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NC_018930.2  NT_011109.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZNF814 gene promoter:
         MEF-2A   HFH-3   FOXI1   Nkx6-1   aMEF-2   RSRFC4   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for ZNF814

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF814


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.43   Ensembl cytogenetic band:  19q13.43   HGNC cytogenetic band: 19q13.43

ZNF814 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF814 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M058361:  view genomic region     (about GC identifiers)

Start:
58,360,099 bp from pter      End:
58,400,442 bp from pter
Size:
40,344 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ZN814_HUMAN, B7Z6K7 (See protein sequence)
Recommended Name: Putative uncharacterized zinc finger protein 814  
Size: 855 amino acids; 97337 Da
Secondary accessions: A6NF35

Explore the universe of human proteins at neXtProt for ZNF814: NX_B7Z6K7

Explore proteomics data for ZNF814 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ZNF814 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001138461.1  
    ENSEMBL proteins: 
     ENSP00000470328   ENSP00000470296   ENSP00000469912   ENSP00000471385   ENSP00000469704  
     ENSP00000471045   ENSP00000472089   ENSP00000470748   ENSP00000410545   ENSP00000469641  

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    antibodies-online kits for ZNF814 (2 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR001909 Krueppel-associated_box
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry B7Z6K7

    ProtoNet protein and cluster: B7Z6K7

    UniProtKB/Swiss-Prot: ZN814_HUMAN, B7Z6K7
    Similarity: Contains 23 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    Find genes that share domains with ZNF814           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IBA--
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with ZNF814           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for ZNF814

    miRNA
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    miRTarBase miRNAs that target ZNF814:
    hsa-mir-26a-5p (MIRT050054), hsa-mir-193b-3p (MIRT041253), hsa-mir-504-5p (MIRT041074)

    Block miRNA regulation of human, mouse, rat ZNF814 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ZNF814 (see all 10):
    hsa-miR-181c hsa-miR-1260b hsa-miR-181a hsa-miR-181d hsa-miR-1260 hsa-miR-188-3p hsa-miR-199a-5p hsa-miR-199b-5p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular IEA--

    Find genes that share ontologies with ZNF814           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF814
    Interactions:

        Search GeneGlobe Interaction Network for ZNF814

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-templated IBA--

    Find genes that share ontologies with ZNF814           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
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    Browse Tocris compounds for ZNF814 (ZN814)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ZNF814 gene: 
    NM_001144989.1  

    Unigene Cluster for ZNF814:

    Zinc finger protein 814
    Hs.634143  [show with all ESTs]
    Unigene Representative Sequence: NM_001144989
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000597652 ENST00000596604 ENST00000597342 ENST00000597832 ENST00000595894
    ENST00000595295 ENST00000596184 ENST00000597348 ENST00000600634 ENST00000595048
    ENST00000594629 ENST00000594159 ENST00000435989(uc002qqk.2 uc010yhl.2 uc002qqo.2 uc002qqp.3)
    ENST00000597807
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate ZNF814 (see all 10):
    hsa-miR-181c hsa-miR-1260b hsa-miR-181a hsa-miR-181d hsa-miR-1260 hsa-miR-188-3p hsa-miR-199a-5p hsa-miR-199b-5p
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      QuantiFast Probe-based Assays in human, mouse, rat ZNF814

    Additional mRNA sequence: 

    AF086563.1 AK022663.1 AK091350.1 AK300483.1 BC026064.2 BC056684.1 

    Selected DOTS entries (see all 27):

    DT.305829  DT.40114240  DT.100773929  DT.40128049  DT.91671501  DT.91802392  DT.91653802  DT.40211539 
    DT.91749895  DT.100773930  DT.86821299  DT.86853024  DT.95369520  DT.100035962  DT.100685851  DT.100730539 
    DT.100751796  DT.100751797  DT.100773927  DT.102843465  DT.121503633  DT.121503658  DT.86851471  DT.121503760 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZNF814 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTACATTCTG
    ZNF814 Expression
    About this image


    ZNF814 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Brain (Nervous System)
             Medulla Oblongata
    ZNF814 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZNF814 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.634143
        Custom PCR Arrays for ZNF814
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF814

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ZNF814 gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfp9455 zinc finger protein 945   --   17 (11.40 cM) 22849030 
    chicken
    (Gallus gallus)
    Aves ZNF8146
    zinc finger protein 814
    41(a)
    1 ↔ 1
    2(382547-405259)
    lizard
    (Anolis carolinensis)
    Reptilia ZNF8146
    zinc finger protein 814
    39(a)
    1 ↔ 1
    AAWZ02037823(6168-8108)
    zebrafish
    (Danio rerio)
    Actinopterygii CU672268.16
    si:zfos-44a5.26
    (see all 14)
    si:zfos-44a5.2
    (see all 14)
    43(a)
    43(a)
    (see all 14)
    many ↔ many
    many ↔ many
    (see all 14)
    3(7791025-7806093) ENSDARG00000091679
    3(62175530-62185073) ENSDARG00000091987


    ENSEMBL Gene Tree for ZNF814 (if available)
    TreeFam Gene Tree for ZNF814 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZNF814 gene
    ZNF6162  ZNF4732  ZNF1602  ZNF4932  ZNF5462  ZNF992  ZNF8362  ZNF7212  
    ZNF5942  ZFP622  ZNF8412  ZNF432  ZNF780B2  ZNF1972  ZNF1072  ZNF585A2  
    ZNF8082  ZNF3472  ZNF8452  ZNF585B2  ZNF6582  ZNF6292  ZNF6242  ZNF2682  
    Selected SIMAP similar genes for ZNF814 using alignment to 9 protein entries:     ZN814_HUMAN (see all proteins) (see all similar genes):
    ZNF552    ZNF78L1    ZNF418    ZNF776    ZNF577    ZNF586
    ZNF738    kr-znf3    ZNF587B    ZNF649    ZNF417    TCF4
    ZFS-4    ZNF17    ZNF350    ZNF211    DKFZp666C237    ZNF826P

    Find genes that share paralogs with ZNF814           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZNF814 (see all 492)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1422998021,2
    C--58380291(+) AACTC-/TGTATCT 1 -- ds50010--------
    rs8908671,2
    C,F,A,H--58380337(-) CAAGGT/CTTAAA 1 -- ds500112Minor allele frequency- C:0.47NA WA CSA EA 510
    rs20120341,2
    C,F,A,H--58380385(-) CACCCA/GGCCCA 1 -- ds50017Minor allele frequency- G:0.37NA WA CSA 248
    rs23751601,2
    C,F--58380389(-) accacA/Gcccag 1 -- ds50011Minor allele frequency- G:0.39WA 118
    rs28890081,2
    F--58380391(-) gcaccA/Gcaccc 1 -- ds50011Minor allele frequency- G:0.26EA 120
    rs28890071,2
    C,F--58380396(-) tagagC/Gcacca 1 -- ds50013Minor allele frequency- G:0.17NA WA 6
    rs561460991,2
    --58380430(+) AGGCCA/GAGGCA 1 -- ds50010--------
    rs1911894861,2
    C--58380479(+) TAACAC/TGGTGA 1 -- ds50010--------
    rs1826482341,2
    --58380557(+) TGCTCA/GGGAGG 1 -- ds50010--------
    rs1464065991,2
    C--58380715(+) AAAAC-/AAAAAA 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for ZNF814 (58360099 - 58400442 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for ZNF814:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2719092CNV Deletion23290073
    esv2719093CNV Deletion23290073
    esv2302097CNV Deletion18987734
    esv1001775CNV Deletion20482838
    nsv912529CNV Loss21882294
    nsv912528CNV Gain21882294
    nsv7311OTHER Inversion18451855

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZNF814 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with ZNF814)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (Nature 2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 730051 HGNC: 33258 Ensembl:ENSG00000204514 euGenes: HUgn730051 ECgene: ZNF814
    H-InvDB: ZNF814

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZNF814 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZNF814 gene:
    Search GeneIP for patents involving ZNF814

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

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