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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ZNF814 Gene

protein-coding GIFtS: 37
GCID: GC19M058380

zinc finger protein 814

Search for ZNF814
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Zinc Finger Protein 814¹ ²
Putative Uncharacterized Zinc Finger Protein 814²
Putative Zinc Finger Protein LOC730051³

External Ids:	HGNC: 33258¹	Entrez Gene: 730051²	Ensembl: ENSG00000204514⁷	UniProtKB: B7Z6K7³

Export aliases for ZNF814 gene to outside databases

Previous GC identifers: GC19U900727 GC19M063072 GC19M054692

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000019.9 NC_018930.1 NT_011109.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ZNF814 gene promoter:
MEF-2A HFH-3 FOXI1 Nkx6-1 aMEF-2 RSRFC4
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search SABiosciences Chromatin IP Primers for ZNF814

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF814

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.43 Ensembl cytogenetic band: 19q13.43 HGNC cytogenetic band: 19q13.43

ZNF814 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF814 gene location

GeneLoc information about chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19M058380: view genomic region (about GC identifiers)

Start:	58,380,747 bp from pter	End:	58,400,442 bp from pter
Size:	19,696 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ZN814_HUMAN, B7Z6K7 (See protein sequence)

Recommended Name: Putative uncharacterized zinc finger protein 814

Size: 855 amino acids; 97337 Da

Secondary accessions: A6NF35

Explore the universe of human proteins at neXtProt for ZNF814: NX_B7Z6K7

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_B7Z6K7

ZNF814 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_001138461.1

ENSEMBL proteins:

ENSP00000410545

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Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	IEA	--

ZNF814 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ZNF814 for domains About GeneDecksing

4 InterPro domains/families:

IPR015880 Znf_C2H2-like

IPR001909 Krueppel-associated_box

IPR013087 Znf_C2H2/integrase_DNA-bd

IPR007087 Znf_C2H2

Graphical View of Domain Structure for InterPro Entry B7Z6K7

ProtoNet protein and cluster: B7Z6K7

UniProtKB/Swiss-Prot: ZN814_HUMAN, B7Z6K7

Similarity: Contains 23 C2H2-type zinc fingers

Similarity: Contains 1 KRAB domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003676	nucleic acid binding	IEA	--
GO:0008270	zinc ion binding	IEA	--

ZNF814 for ontologies About GeneDecksing

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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for ZNF814

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006355	regulation of transcription, DNA-dependent	IEA	--

ZNF814 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
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About This Section

REFSEQ mRNAs for ZNF814 gene:

NM_001144989.1

Unigene Clusters for ZNF814:

Zinc finger protein 814

Hs.634143 [show with all ESTs], Hs.733810 [show with all ESTs]

Unigene Representative Sequences: NM_001144989, AK096401

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000435989(uc002qqk.2 uc010yhl.2 uc002qqo.2 uc002qqp.3)

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Additional cDNA sequence: AK096401.1

24/29 DOTS entries (see all 29):

DT.305829 DT.40114240 DT.100773929 DT.40128049 DT.99993016 DT.91671501 DT.91802392 DT.426488

DT.91653802 DT.40211539 DT.91749895 DT.100773930 DT.86821299 DT.86853024 DT.95369520 DT.100035962

DT.100685851 DT.100730539 DT.100751796 DT.100751797 DT.100773927 DT.102843465 DT.121503633 DT.121503658

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ZNF814 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTACATTCTG

About this image

ZNF814 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Brain

Medulla Oblongata

Brain

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See ZNF814 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZNF814

SOURCE GeneReport for Unigene clusters: Hs.634143 Hs.733810

SABiosciences Custom PCR Arrays for ZNF814

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for ZNF814 gene from 2/6 species (see all 6) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	-- ZNF250⁶ (see all 8)	zinc finger protein 85 (HPF4, HTF1) (see all 8)	49(a) 48(a) (see all 8)	1 ↔ many 1 ↔ many (see all 8)	Un(54547117-54550735) 18(22140-94009)
lizard (Anolis carolinensis)	Reptilia	-- -- (see all 174)	--	57(a) 55(a) (see all 174)	possible ortholog possible ortholog (see all 174)	GL343829.1(48346-49953) GL343571.1(186271-187299)

ENSEMBL Gene Tree for ZNF814 (if available)
TreeFam Gene Tree for ZNF814 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs142299802^1,2	C	--	58380291(+)	`AACTC-/TGTATCT`	1	--	ds500¹		0	--	--	--	--
rs890867^1,2	C,F,A,H	--	58380337(-)	`CAAGGT/CTTAAA`	1	--	ds500¹		12		NA WA CSA EA	510
rs2012034^1,2	C,F,A,H	--	58380385(-)	`CACCCA/GGCCCA`	1	--	ds500¹		7		NA WA CSA	248
rs2375160^1,2	F	--	58380389(-)	`accacA/Gcccag`	1	--	ds500¹		1		WA	118
rs2889008^1,2	F	--	58380391(-)	`gcaccA/Gcaccc`	1	--	ds500¹		1		EA	120
rs2889007^1,2	C	--	58380396(-)	`tagagC/Gcacca`	1	--	ds500¹		3		NA WA	6
rs56146099^1,2		--	58380430(+)	`AGGCCA/GAGGCA`	1	--	ds500¹		0	--	--	--	--
rs191189486^1,2		--	58380479(+)	`TAACAC/TGGTGA`	1	--	ds500¹		0	--	--	--	--
rs182648234^1,2		--	58380557(+)	`TGCTCA/GGGAGG`	1	--	ds500¹		0	--	--	--	--
rs146406599^1,2		--	58380709(+)	`AAAAC-/AAAAAA`	1	--	ds500¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for ZNF814 (58380747 - 58400442 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for ZNF814
1 Indel: 45808

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ZNF814 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ZNF814)

Utopia: connect your pdf to the dynamic
world of online information

The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)^{1, 2} Grimwood J.... Lucas S.M. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)¹ Kimura K.... Sugano S. (2006)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 730051	HGNC: 33258	Ensembl:ENSG00000204514	euGenes: HUgn730051	ECgene: ZNF814
H-InvDB: ZNF814

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ZNF814	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ZNF814 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for ZNF814 gene:
Search GeneIP for patents involving ZNF814

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section


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GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 13 May 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
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ZNF814 Gene

zinc finger protein 814

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ZNF814 Gene

zinc finger protein 814

Aliasesfor ZNF814 gene

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Protein Domains /Familiesfor ZNF814 gene

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for ZNF814 gene

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for ZNF814 gene

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for ZNF814 gene

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for ZNF814 gene

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for ZNF814 gene

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for ZNF814 gene

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for ZNF814 gene

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for ZNF814 gene

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