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Aliases for ZNF81 Gene

Aliases for ZNF81 Gene

  • Zinc Finger Protein 81 2 3
  • MRX45 3 6
  • HFZ20 3 4
  • Mental Retardation, X-Linked 45 2
  • Zinc Finger Protein 81 (HFZ20) 2
  • DJ54B20.6 3

External Ids for ZNF81 Gene

Previous HGNC Symbols for ZNF81 Gene

  • MRX45

Previous GeneCards Identifiers for ZNF81 Gene

  • GC0XU990240
  • GC0XM046035
  • GC0XM046352
  • GC0XP046779
  • GC0XP047452
  • GC0XP047581
  • GC0XP047696
  • GC0XP045408

Summaries for ZNF81 Gene

Entrez Gene Summary for ZNF81 Gene

  • This gene encodes a protein that likely functions as a transcription factor. The protein contains an N-terminal KRAB domain and several C2H2-type zinc finger motifs. Mutations in this gene cause mental retardation X-linked type 45 (MRX45). [provided by RefSeq, May 2010]

GeneCards Summary for ZNF81 Gene

ZNF81 (Zinc Finger Protein 81) is a Protein Coding gene. Diseases associated with ZNF81 include non-syndromic x-linked intellectual disability and aland island eye disease. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ZNF182.

UniProtKB/Swiss-Prot for ZNF81 Gene

  • May be involved in transcriptional regulation

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF81 Gene

Genomics for ZNF81 Gene

Regulatory Elements for ZNF81 Gene

Genomic Location for ZNF81 Gene

47,836,871 bp from pter
48,002,561 bp from pter
165,691 bases
Plus strand

Genomic View for ZNF81 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF81 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF81 Gene

Proteins for ZNF81 Gene

  • Protein details for ZNF81 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 81
    Protein Accession:
    Secondary Accessions:
    • Q6RX22
    • Q96QH6

    Protein attributes for ZNF81 Gene

    661 amino acids
    Molecular mass:
    75960 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF81 Gene

Proteomics data for ZNF81 Gene at MOPED

Post-translational modifications for ZNF81 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF81 Gene

No data available for DME Specific Peptides for ZNF81 Gene

Domains for ZNF81 Gene

Gene Families for ZNF81 Gene

  • ZNF :Zinc fingers, C2H2-type

Protein Domains for ZNF81 Gene

Graphical View of Domain Structure for InterPro Entry



  • P51508
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 12 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF81: view

Function for ZNF81 Gene

Molecular function for ZNF81 Gene

GENATLAS Biochemistry: zinc finger protein 81 (H2F10) (C2H2 type,Kruppel-like)
UniProtKB/Swiss-Prot Function: May be involved in transcriptional regulation

Gene Ontology (GO) - Molecular Function for ZNF81 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0003700 sequence-specific DNA binding transcription factor activity IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF81: view

Animal Model Products

CRISPR Products

miRNA for ZNF81 Gene

miRTarBase miRNAs that target ZNF81

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF81

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for ZNF81 Gene

Localization for ZNF81 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF81 Gene

Subcellular locations from

Jensen Localization Image for ZNF81 Gene COMPARTMENTS Subcellular localization image for ZNF81 gene
Compartment Confidence
nucleus 5
cytosol 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for ZNF81 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF81: view

Pathways for ZNF81 Gene

SuperPathways for ZNF81 Gene

No Data Available

Interacting Proteins for ZNF81 Gene

Gene Ontology (GO) - Biological Process for ZNF81 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA --
genes like me logo Genes that share ontologies with ZNF81: view

No data available for Pathways by source for ZNF81 Gene

Transcripts for ZNF81 Gene

Unigene Clusters for ZNF81 Gene

Zinc finger protein 81:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF81

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for ZNF81
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF81 Gene

No ASD Table

Relevant External Links for ZNF81 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF81 Gene

mRNA expression in normal human tissues for ZNF81 Gene

SOURCE GeneReport for Unigene cluster for ZNF81 Gene Hs.114246

genes like me logo Genes that share expressions with ZNF81: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein expression and mRNA Expression by UniProt/SwissProt for ZNF81 Gene

Orthologs for ZNF81 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF81 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF81 35
  • 99.85 (n)
  • 99.85 (a)
ZNF81 36
  • 100 (a)
(Bos Taurus)
Mammalia ZNF81 35
  • 88.5 (n)
  • 86.23 (a)
ZNF81 36
  • 87 (a)
(Canis familiaris)
Mammalia ZNF81 35
  • 90.12 (n)
  • 87.59 (a)
ZNF81 36
  • 78 (a)
(Rattus norvegicus)
Mammalia LOC100363372 35
  • 81.74 (n)
  • 75.11 (a)
Species with no ortholog for ZNF81:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF81 Gene

Gene Tree for ZNF81 (if available)
Gene Tree for ZNF81 (if available)

Paralogs for ZNF81 Gene

Selected SIMAP similar genes for ZNF81 Gene using alignment to 4 proteins: Pseudogenes for ZNF81 Gene

genes like me logo Genes that share paralogs with ZNF81: view

Variants for ZNF81 Gene

Sequence variations from dbSNP and Humsavar for ZNF81 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs480186 -- 47,919,483(-) gggta(A/G)agggg utr-variant-3-prime
rs482066 -- 47,919,288(-) tcaat(A/G)gaaat utr-variant-3-prime
rs486108 -- 47,913,452(-) gctca(C/T)ggcag intron-variant
rs502054 -- 47,916,909(-) TTTCT(A/G)TAGGA utr-variant-3-prime
rs511023 -- 47,913,049(-) TCCAG(A/G)TGTAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF81 Gene

Variant ID Type Subtype PubMed ID
esv2545209 CNV Deletion 19546169
dgv2442e1 CNV Complex 17122850
esv271510 CNV Insertion 20981092

Relevant External Links for ZNF81 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)
Locus Specific Mutation Databases (LSDB)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF81 Gene

Disorders for ZNF81 Gene

(1) OMIM Diseases for ZNF81 Gene (314998)


  • Mental retardation, X-linked 45 (MRX45) [MIM:300498]: A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. Intellectual deficiency is the only primary symptom of non-syndromic X-linked mental retardation, while syndromic mental retardation presents with associated physical, neurological and/or psychiatric manifestations. {ECO:0000269 PubMed:15121780}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Note=A chromosomal aberration involving ZNF81 is found in a severe mental retardation patient. Translocation t(X;9)(p11.23;q34.3).

(2) University of Copenhagen DISEASES for ZNF81 Gene

genes like me logo Genes that share disorders with ZNF81: view

Publications for ZNF81 Gene

  1. A novel X-linked member of the human zinc finger protein gene family: isolation, mapping, and expression. (PMID: 8507979) Marino M. … Grimaldi G. (Mamm. Genome 1993) 2 3 4
  2. Zinc finger 81 (ZNF81) mutations associated with X-linked mental retardation. (PMID: 15121780) Kleefstra T. … van Bokhoven H. (J. Med. Genet. 2004) 2 3 4
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  4. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 4
  5. Clustered organization of KrA1ppel zinc-finger genes at Xp11.23, flanking a translocation breakpoint at OATL1: a physical map with locus assignments for ZNF21, ZNF41, ZNF81, and ELK1. (PMID: 8088786) Knight J.C. … Coleman M.P. (Genomics 1994) 3

Products for ZNF81 Gene

Sources for ZNF81 Gene

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