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ZNF805 Gene

protein-coding   GIFtS: 40
GCID: GC19P057752

Zinc Finger Protein 805

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disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger Protein 8051 2
CTC-444N24.82

External Ids:    HGNC: 232721   Entrez Gene: 3909802   Ensembl: ENSG000002045247   UniProtKB: Q5CZA53   

Export aliases for ZNF805 gene to outside databases

Previous GC identifers: GC19P062456 GC19P054064


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZNF805 Gene:
ZNF805 (zinc finger protein 805) is a protein-coding gene. An important paralog of this gene is ZNF80.

UniProtKB/Swiss-Prot: ZN805_HUMAN, Q5CZA5
Function: May be involved in transcriptional regulation (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NC_018930.2  NT_011109.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZNF805 gene promoter:
         GR   FOXF2   AML1a   GCNF   GR-beta   STAT5A   GCNF-1   GR-alpha   GCNF-2   Hlf   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for ZNF805

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF805


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.43   Ensembl cytogenetic band:  19q13.43   HGNC cytogenetic band: 19q13.43

ZNF805 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF805 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P057752:  view genomic region     (about GC identifiers)

Start:
57,751,973 bp from pter      End:
57,774,106 bp from pter
Size:
22,134 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ZN805_HUMAN, Q5CZA5 (See protein sequence)
Recommended Name: Zinc finger protein 805  
Size: 627 amino acids; 71143 Da
Sequence caution: Sequence=CAI56760.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: B4DNM5
Alternative splicing: 2 isoforms:  Q5CZA5-1   Q5CZA5-2   (Gene prediction based on similarity to orthologs)

Explore the universe of human proteins at neXtProt for ZNF805: NX_Q5CZA5

Explore proteomics data for ZNF805 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ZNF805 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001018857.2  NP_001138550.1  

    ENSEMBL proteins: 
     ENSP00000365414   ENSP00000412999   ENSP00000440067  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR001909 Krueppel-associated_box
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q5CZA5

    ProtoNet protein and cluster: Q5CZA5

    UniProtKB/Swiss-Prot: ZN805_HUMAN, Q5CZA5
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 13 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    Find genes that share domains with ZNF805           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN805_HUMAN, Q5CZA5
    Function: May be involved in transcriptional regulation (By similarity)

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with ZNF805           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for ZNF805

    miRNA
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    miRTarBase miRNAs that target ZNF805:
    hsa-let-7e-5p (MIRT051652), hsa-mir-454-3p (MIRT039235), hsa-mir-93-5p (MIRT028005), hsa-mir-425-5p (MIRT016664), hsa-mir-7-5p (MIRT025803), hsa-mir-186-5p (MIRT021207), hsa-let-7b-5p (MIRT052075)

    Block miRNA regulation of human, mouse, rat ZNF805 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ZNF805 (see all 25):
    hsa-miR-498 hsa-miR-605 hsa-miR-3133 hsa-miR-378b hsa-miR-924 hsa-miR-186 hsa-miR-378 hsa-miR-520g
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZN805_HUMAN, Q5CZA5: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--

    Find genes that share ontologies with ZNF805           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF805
    Interactions:

        Search GeneGlobe Interaction Network for ZNF805

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--

    Find genes that share ontologies with ZNF805           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZNF805 (ZN805)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ZNF805 gene (2 alternative transcripts): 
    NM_001023563.3  NM_001145078.1  

    Unigene Cluster for ZNF805:

    Zinc finger protein 805
    Hs.22488  [show with all ESTs]
    Unigene Representative Sequence: NM_001023563
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000354309(uc010ygu.2) ENST00000414468(uc010ygt.2) ENST00000535550

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate ZNF805 (see all 25):
    hsa-miR-498 hsa-miR-605 hsa-miR-3133 hsa-miR-378b hsa-miR-924 hsa-miR-186 hsa-miR-378 hsa-miR-520g
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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      QuantiFast Probe-based Assays in human, mouse, rat ZNF805

    Additional mRNA sequence: 

    AF024708.1 AK297977.1 BC140786.1 CR936617.1 

    4 DOTS entries:

    DT.442491  DT.95358759  DT.91740216  DT.97789457 

    4 AceView cDNA sequences:

    BX091482 AI017912 BE154026 AI948953 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZNF805 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GACTTTTATG
    ZNF805 Expression
    About this image

    ZNF805 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZNF805 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.22488
        Custom PCR Arrays for ZNF805
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ZNF805 gene from Selected species (see all 4)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    dog
    (Canis familiaris)
    Mammalia ZNF8051 zinc finger protein 805 86.46(n)
    86.41(a)
      100685869  XM_005616078.1  XP_005616135.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    41(a)
    1 → many
    GL344452.1(42241-44649)
    zebrafish
    (Danio rerio)
    Actinopterygii si:dkey-7j22.36
    CU138542.36
    Uncharacterized protein
    51(a)
    43(a)
    many ↔ many
    many ↔ many
    4(50336373-50347976) ENSDARG00000088640
    Zv9_scaffold3506(185121-205552) ENSDARG00000088627


    ENSEMBL Gene Tree for ZNF805 (if available)
    TreeFam Gene Tree for ZNF805 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZNF805 gene
    ZNF802  ZNF4602  ZNF5992  ZNF5432  ZNF5502  ZNF2642  
    Selected SIMAP similar genes for ZNF805 using alignment to 2 protein entries:     ZN805_HUMAN (see all proteins) (see all similar genes):
    ZNF264    ZNF543    kr-znf3    ZNF78L1    ZNF818P    DKFZp666C237
    ZFS-4    ZNF484    zf30    ZNF345    ZNF323    ZNF599
    HZF16    HZF30    ZNF826P    ZNF460    ZFS-1    ZNF501

    Find genes that share paralogs with ZNF805           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZNF805 (see all 561)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1488925501,2
    --57750062(+) AACTTA/GAAATA 2 -- us2k10--------
    rs7581001,2
    C,F,O,A,H--57750186(+) TCAAAC/TTGATC 2 -- us2k113Minor allele frequency- T:0.20MN NA NS EA WA 974
    rs1470214001,2
    --57750357(+) ATTTGC/TAACAT 2 -- us2k10--------
    rs1926250851,2
    --57750529(+) AAATTG/TTTTTT 2 -- us2k10--------
    rs755379991,2
    C--57750537(+) TTTGAG/TTAGGC 2 -- us2k10--------
    rs1381137141,2
    --57750600(+) GTGGAA/TCACTT 2 -- us2k10--------
    rs1168287091,2
    C,F--57750674(+) AAAACA/GAAAAA 2 -- us2k11Minor allele frequency- G:0.02WA 118
    rs1124347501,2
    F--57750744(+) AGGTGG/AGAGGA 2 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs1119523501,2
    C,F--57750773(+) TTGAGG/TCTGCA 2 -- us2k11Minor allele frequency- T:0.50NA 2
    rs1126327381,2
    C,F--57750828(+) CGAGAC/TCCTGT 2 -- us2k11Minor allele frequency- T:0.50WA 2

    HapMap Linkage Disequilibrium report for ZNF805 (57751973 - 57774106 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for ZNF805:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv588e201CNV Deletion23290073
    esv2719069CNV Deletion23290073
    esv1942885CNV Deletion18987734
    esv22387CNV Loss19812545

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with ZNF805           About GenesLikeMe

    Genetic Association Database (GAD): ZNF805

    Export disorders for ZNF805 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZNF805 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with ZNF805)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genome-wide association scan of quantitative traits for attention deficit hyperactivity disorder identifies novel associations and confirms candidate gene associations. (PubMed id 18821565)1, 4 Lasky-Su J....Faraone S.V. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2008)
    2. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)
    3. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (Nature 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 390980 HGNC: 23272 AceView: LOC390980 Ensembl:ENSG00000204524 euGenes: HUgn390980
    ECgene: ZNF805 H-InvDB: ZNF805

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZNF805 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZNF805 gene:
    Search GeneIP for patents involving ZNF805

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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