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Aliases for ZNF804A Gene

Aliases for ZNF804A Gene

  • Zinc Finger Protein 804A 2 3 5
  • C2orf10 3 4
  • EC 2.3.1.181 61
  • EC 6.3.4.2 61

External Ids for ZNF804A Gene

Previous HGNC Symbols for ZNF804A Gene

  • C2orf10

Previous GeneCards Identifiers for ZNF804A Gene

  • GC02P185172
  • GC02P185463
  • GC02P177322

Summaries for ZNF804A Gene

Entrez Gene Summary for ZNF804A Gene

  • The protein encoded by this gene is a zinc finger binding protein. Polymorphisms in this gene, especially rs1344706, are thought to confer increased susceptibility to schizophrenia, bipolar disorder, and heroin addiciton. [provided by RefSeq, Nov 2015]

GeneCards Summary for ZNF804A Gene

ZNF804A (Zinc Finger Protein 804A) is a Protein Coding gene. Diseases associated with ZNF804A include Bipolar Disorder and Schizophrenia. An important paralog of this gene is ZNF804B.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF804A Gene

Genomics for ZNF804A Gene

Regulatory Elements for ZNF804A Gene

Enhancers for ZNF804A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02G184637 0.5 ENCODE 11.8 +39.9 39877 1.0 SMARCA4 POLR2A HNF4A ZNF804A LOC105373780 RPL23AP33
GH02G184562 0.9 FANTOM5 Ensembl 5.3 -35.7 -35672 0.6 ZNF316 CEBPB CEBPG MAFK ATF2 ZNF804A LOC105373779
GH02G184731 0.3 FANTOM5 2.4 +133.1 133054 0.3 ZNF804A LOC105373780 RPL23AP33
GH02G184596 0.8 ENCODE 0.7 +0.3 272 4.1 TBP CTCF MXI1 FOXA2 SUZ12 MAX CEBPG RAD21 E2F1 ZFHX2 LOC105373780 ZNF804A
GH02G184462 0.7 ENCODE 0.1 -135.5 -135509 1.7 TAF1 CEBPB MAX CEBPG RAD21 FOXA1 YY1 JUND ZNF316 POLR2A LOC105373779 ZNF804A
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF804A on UCSC Golden Path with GeneCards custom track

Promoters for ZNF804A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000295144 -266 2601 TBP CTCF MXI1 FOXA2 SUZ12 MAX CEBPG RAD21 E2F1 ZFHX2
ENSR00000127400 1934 1001 SUZ12 EZH2

Genomic Location for ZNF804A Gene

Chromosome:
2
Start:
184,598,366 bp from pter
End:
184,939,492 bp from pter
Size:
341,127 bases
Orientation:
Plus strand

Genomic View for ZNF804A Gene

Genes around ZNF804A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF804A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF804A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF804A Gene

Proteins for ZNF804A Gene

  • Protein details for ZNF804A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z570-Z804A_HUMAN
    Recommended name:
    Zinc finger protein 804A
    Protein Accession:
    Q7Z570
    Secondary Accessions:
    • A7E253
    • Q6ZN26

    Protein attributes for ZNF804A Gene

    Size:
    1209 amino acids
    Molecular mass:
    136888 Da
    Quaternary structure:
    • Interacts with ATXN1.

neXtProt entry for ZNF804A Gene

Selected DME Specific Peptides for ZNF804A Gene

Q7Z570:
  • EFARNVA
  • EGLTDYE

Post-translational modifications for ZNF804A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF804A Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for ZNF804A Gene

Protein Domains for ZNF804A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF804A Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ZNF804A: view

No data available for Gene Families and UniProtKB/Swiss-Prot for ZNF804A Gene

Function for ZNF804A Gene

Enzyme Numbers (IUBMB) for ZNF804A Gene

Gene Ontology (GO) - Molecular Function for ZNF804A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF804A: view

Phenotypes for ZNF804A Gene

GenomeRNAi human phenotypes for ZNF804A:
genes like me logo Genes that share phenotypes with ZNF804A: view

Animal Model Products

CRISPR Products

miRNA for ZNF804A Gene

miRTarBase miRNAs that target ZNF804A

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF804A Gene

Localization for ZNF804A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF804A gene
Compartment Confidence
nucleus 3

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ZNF804A Gene

Pathways & Interactions for ZNF804A Gene

SuperPathways for ZNF804A Gene

No Data Available

Interacting Proteins for ZNF804A Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000303252%0d%0a9606.ENSP00000244769%0d%0a
Selected Interacting proteins: ENSP00000303252 Q7Z570-Z804A_HUMAN for ZNF804A Gene via STRING IID

Gene Ontology (GO) - Biological Process for ZNF804A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ZNF804A Gene

Drugs & Compounds for ZNF804A Gene

(1) Drugs for ZNF804A Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
antipsychotics Pharma 0
genes like me logo Genes that share compounds with ZNF804A: view

Transcripts for ZNF804A Gene

mRNA/cDNA for ZNF804A Gene

(1) REFSEQ mRNAs :
(10) Additional mRNA sequences :
(24) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF804A Gene

Zinc finger protein 804A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF804A Gene

No ASD Table

Relevant External Links for ZNF804A Gene

GeneLoc Exon Structure for
ZNF804A
ECgene alternative splicing isoforms for
ZNF804A

Expression for ZNF804A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF804A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ZNF804A Gene

This gene is overexpressed in Brain - Anterior cingulate cortex (BA24) (x4.8), Brain - Hypothalamus (x4.8), Brain - Cerebellar Hemisphere (x4.8), Brain - Frontal Cortex (BA9) (x4.1), and Brain - Nucleus accumbens (basal ganglia) (x4.1).

Protein differential expression in normal tissues from HIPED for ZNF804A Gene

This gene is overexpressed in Liver (64.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF804A Gene



Protein tissue co-expression partners for ZNF804A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF804A Gene:

ZNF804A

SOURCE GeneReport for Unigene cluster for ZNF804A Gene:

Hs.159528

Evidence on tissue expression from TISSUES for ZNF804A Gene

  • Nervous system(4.5)
genes like me logo Genes that share expression patterns with ZNF804A: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF804A Gene

Orthologs for ZNF804A Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF804A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF804A 34 35
  • 99.28 (n)
cow
(Bos Taurus)
Mammalia ZNF804A 34 35
  • 85.92 (n)
mouse
(Mus musculus)
Mammalia Zfp804a 34 16 35
  • 77.36 (n)
rat
(Rattus norvegicus)
Mammalia Zfp804a 34
  • 77.08 (n)
oppossum
(Monodelphis domestica)
Mammalia ZNF804A 35
  • 59 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF804A 35
  • 54 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZNF804A 35
  • 47 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZNF804A 34 35
  • 61.21 (n)
lizard
(Anolis carolinensis)
Reptilia ZNF804A 35
  • 46 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii znf804a 35
  • 27 (a)
OneToOne
Species where no ortholog for ZNF804A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF804A Gene

ENSEMBL:
Gene Tree for ZNF804A (if available)
TreeFam:
Gene Tree for ZNF804A (if available)

Paralogs for ZNF804A Gene

Paralogs for ZNF804A Gene

genes like me logo Genes that share paralogs with ZNF804A: view

Variants for ZNF804A Gene

Sequence variations from dbSNP and Humsavar for ZNF804A Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
VAR_035599 A colorectal cancer sample
rs61739288 Benign 184,937,029(+) ACACA(A/G)GTCAG reference, missense
rs1000014329 -- 184,934,005(+) GTTGA(A/C)AGCTA intron-variant
rs1000035923 -- 184,668,416(+) ATTTT(C/T)TGACA intron-variant
rs1000038672 -- 184,867,947(+) TATTA(A/T)CATTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF804A Gene

Variant ID Type Subtype PubMed ID
dgv232n21 CNV loss 19592680
dgv4114n100 CNV gain 25217958
dgv755e214 CNV gain 21293372
esv1929674 CNV deletion 18987734
esv2658623 CNV deletion 23128226
esv3305992 CNV mobile element insertion 20981092
esv3310367 CNV mobile element insertion 20981092
esv3423325 CNV insertion 20981092
esv3593625 CNV loss 21293372
esv3593626 CNV loss 21293372
esv3593627 CNV loss 21293372
esv3893517 CNV gain+loss 25118596
nsv1160890 CNV duplication 26073780
nsv3069 CNV insertion 18451855
nsv508189 CNV deletion 20534489
nsv517466 CNV gain 19592680
nsv520974 CNV loss 19592680
nsv818104 CNV gain 17921354
nsv821846 CNV gain 20364138
nsv834484 CNV gain 17160897

Variation tolerance for ZNF804A Gene

Residual Variation Intolerance Score: 69.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 25.20; 99.70% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF804A Gene

Human Gene Mutation Database (HGMD)
ZNF804A
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF804A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF804A Gene

Disorders for ZNF804A Gene

MalaCards: The human disease database

(3) MalaCards diseases for ZNF804A Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
bipolar disorder
  • bipolar depression
schizophrenia
  • schizophrenia 12
disease of mental health
  • mental health
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ZNF804A

Genetic Association Database (GAD)
ZNF804A
Human Genome Epidemiology (HuGE) Navigator
ZNF804A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF804A
genes like me logo Genes that share disorders with ZNF804A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF804A Gene

Publications for ZNF804A Gene

  1. Expanding the range of ZNF804A variants conferring risk of psychosis. (PMID: 20048749) Steinberg S. … Stefansson K. (Mol. Psychiatry 2011) 3 46 64
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  3. Replication of association between schizophrenia and ZNF804A in the Irish Case-Control Study of Schizophrenia sample. (PMID: 19844207) Riley B. … Kendler K.S. (Mol. Psychiatry 2010) 3 46 64
  4. Psychosis susceptibility gene ZNF804A and cognitive performance in schizophrenia. (PMID: 20603450) Walters J.T. … Donohoe G. (Arch. Gen. Psychiatry 2010) 3 46 64
  5. No evidence that rare coding variants in ZNF804A confer risk of schizophrenia. (PMID: 20862696) Dwyer S. … O'Donovan M.C. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010) 3 46 64

Products for ZNF804A Gene

Sources for ZNF804A Gene

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