ZNF804A Gene
protein-coding GIFtS: 47
GCID: GC02P185463
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|
zinc finger protein 804A
(Previous symbol: C2orf10)
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Aliases
for ZNF804A gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger Protein 804A1 2 | | C2orf101 2 3 5 | | EC 2.3.1.1818 | | EC 6.3.4.28 |
Export aliases for ZNF804A gene to outside databasesPrevious GC identifers: GC02P185172 GC02P177322 |
Summaries
for ZNF804A gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for ZNF804A gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_005403.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZNF804A gene promoter:
Nkx3-1 Nkx3-1 v4 AML1a Nkx3-1 v1 Gfi-1 Nkx3-1 v2 RORalpha1 S8 POU2F1a Nkx3-1 v3
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZNF804A
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF804A |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2q32.1 Ensembl cytogenetic band: 2q32.1 HGNC cytogenetic band: 2q32.1ZNF804A Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02P185463: view genomic region
(about GC identifiers)
Start:
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185,463,093 bp from pter |
End:
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185,804,219 bp from pter |
Size:
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341,127 bases |
Orientation:
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plus strand |
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Proteins
for ZNF804A gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: Z804A_HUMAN, Q7Z570 (See
protein sequence)Recommended Name: Zinc finger protein 804A Size: 1209 amino acids; 136888 Da
Subunit: Interacts with ATXN1
Secondary accessions: A7E253 Q6ZN26Explore the universe of human proteins at neXtProt for ZNF804A: NX_Q7Z570
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q7Z570
2 DME Specific Peptides for ZNF804A (Q7Z570)
ZNF804A Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_919226.1
ENSEMBL proteins: ENSP00000303252
Human Recombinant Protein Products for ZNF804A:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005622 | intracellular |
IEA | -- |
ZNF804A for ontologies About GeneDecksing
ZNF804A Antibody Products:
Assay Products for ZNF804A: |
Protein
Domains /
Families
for ZNF804A gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZNF804A for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q7Z570ProtoNet protein and cluster: Q7Z570 UniProtKB/Swiss-Prot: Z804A_HUMAN, Q7Z570Similarity: Contains 1 C2H2-type zinc finger |
Function
for ZNF804A gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Enzyme Numbers (IUBMB): EC 2.3.1.1812 EC 6.3.4.22
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008270 | zinc ion binding |
IEA | -- |
ZNF804A for ontologies About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF804A (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF804A
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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Synthesis Service for ZNF804A | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF804A |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF804A |
|
Pathways & Interactions
for ZNF804A gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF804A
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
3 Interacting proteins for ZNF804A (Q7Z5702, 3 ENSP000003032524) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for ZNF804A gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZNF804A
Search CenterWatch for drugs/clinical trials and news about ZNF804A / Z804A
|
Transcripts
for ZNF804A gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZNF804A gene: NM_194250.1 Unigene Cluster for ZNF804A: Zinc finger protein 804A Hs.159528 [show with all ESTs]Unigene Representative Sequence: AY3274071 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000302277(uc002uph.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF804A (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF804A
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ZNF804A (NM_194250) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF804A | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF804A |
Additional cDNA sequence: AF052145.1 AK055275.1 AK127762.1 AK131402.1 AK295280.1 AK307596.1 AY327407.1 BC136602.1 BC142612.1 BC150198.1 1 DOTS entry: DT.91906846 24 AceView cDNA sequences: CA308934 NM_194250 AY327407 CA417236 CD364625 AF052145 BU728482 AK131402 AI916902 AK127762 BP872409 BG253859 AK055275 AI189454 BG251336 AU252746 BM691990 BU581671 T27017 AU254014 R39337 AA452851 BU581346 T79966
GeneLoc Exon Structure
|
Expression
for ZNF804A gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZNF804A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTCCTTGAAA
About this image
See ZNF804A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZNF804A
SOURCE GeneReport for Unigene cluster: Hs.159528
SABiosciences Custom PCR Arrays for ZNF804A
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF804A
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ZNF804A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF804A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF804A | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF804A |
Orthologs
for ZNF804A gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for ZNF804A gene from 5/16 species (see all 16) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
ZNF804A1 |
zinc finger protein 804A |
60.56(n)
50.04(a) |
|
423994 XM_421853.3 XP_421853.3 |
lizard
(Anolis carolinensis) |
Reptilia |
ZNF804A6 |
-- |
45(a) |
1 ↔ 1 |
GL343221.1(761910-774377) |
zebrafish
(Danio rerio) |
Actinopterygii |
LOC5652941 |
zinc finger protein 804A |
47.04(n)
36.19(a) |
|
565294 NM_001122701.1 NP_001116173.1 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
AT5G266106 |
D111/G-patch domain-containing protein |
12(a) |
1 → many |
5(9375183-9377125) |
rice
(Oryza sativa) |
Liliopsida |
-- |
G-patch domain containing protein, expressed |
10(a) |
1 → many |
4(904391-908965) |
ENSEMBL Gene Tree for ZNF804A (if available)
TreeFam Gene Tree for ZNF804A (if available) |
Paralogs
for ZNF804A gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ZNF804A gene
- GPATCH82 ZNF804B2
ZNF804A for paralogs About GeneDecksing
|
Genomic Variants
for ZNF804A gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZNF804A (185463093 - 185713093 bp, first 250kb of ZNF804A)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for ZNF804A
4 CNVs: 50357 4320 50358 9437
Human Gene Mutation Database (HGMD): ZNF804A
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF804A |
|
Disorders
/ Diseases
for ZNF804A gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ZNF804A for disorders About GeneDecksing
OMIM gene information: 612282
OMIM disorders: --
4  diseases for ZNF804A: About MalaCardsmantle cell lymphoma bipolar disorder ataxia schizophrenia
2 diseases from the University of Copenhagen DISEASES database for ZNF804A:Schizophrenia Schizotypal personality disorder Human Genome Epidemiology (HuGE) Navigator: ZNF804A (18 documents)
Export disorders for ZNF804A gene to outside databases
|
Publications
for ZNF804A gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZNF804A gene, integrated from 9 sources (see all 48):
(articles sorted by number of sources associating them with ZNF804A) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. (PubMed id 16713569)1, 2 Lim J.... Zoghbi H.Y. (2006)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- High level of cannabinoid receptor 1, absence of regulator of G protein signalling 13 and differential expression of Cyclin D1 in mantle cell lymphoma. (PubMed id 12970790)1, 3 Islam T.C....Sander B. (2003)
- Evidence that schizophrenia risk variation in the ZNF8 04A gene exerts its effects during fetal brain development. (PubMed id 23212061)1 Hill M.J. and Bray N.J. (2012)
- Influence of ZNF804a on brain structure volumes and sy mptom severity in individuals with schizophrenia. (PubMed id 22945618)1 Wassink T.H....Andreasen N.C. (2012)
- Genome-wide supported psychosis risk variant in ZNF804 A gene and impact on cortico-limbic WM integrity in schizophrenia. (PubMed id 22328493)1 Kuswanto C.N....Sim K. (2012)
- Knockdown of the psychosis susceptibility gene ZNF804A alters expression of genes involved in cell adhesion. (PubMed id 22080834)1 Hill M.J....Bray N.J. (2012)
- The schizophrenia risk gene ZNF804A influences the ant ipsychotic response of positive schizophrenia symptoms. (PubMed id 21892778)1 Mossner R....Maier W. (2012)
- Evidence of IQ-modulated association between ZNF804A g ene polymorphism and cognitive function in schizophrenia patients. (PubMed id 22373944)1 Chen M....Chen C. (2012)
- ZNF804a regulates expression of the schizophrenia-asso ciated genes PRSS16, COMT, PDE4B, and DRD2. (PubMed id 22384243)1 Girgenti M.J....Maher B.J. (2012)
|
External Searches for ZNF804A gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZNF804A gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZNF804A gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZNF804A gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZNF804A | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZNF804A gene:
Search GeneIP for patents involving ZNF804A
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZNF804A gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ZNF804A | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZNF804A | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF804A | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ZNF804A | | OriGene 3'-UTR Clone for ZNF804A | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF804A | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF804A | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ZNF804A | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF804A | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF804A | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZNF804A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF804A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF804A |
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 | | | ZNF804A Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF804A |
|  |  |  |  | | | | Search ThermoFisher Antibodies for ZNF804A |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF804A |
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