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Aliases for ZNF804A Gene

Aliases for ZNF804A Gene

  • Zinc Finger Protein 804A 2 3
  • C2orf10 3 4
  • EC 63
  • EC 63

External Ids for ZNF804A Gene

Previous HGNC Symbols for ZNF804A Gene

  • C2orf10

Previous GeneCards Identifiers for ZNF804A Gene

  • GC02P185172
  • GC02P185463
  • GC02P177322

Summaries for ZNF804A Gene

Entrez Gene Summary for ZNF804A Gene

  • The protein encoded by this gene is a zinc finger binding protein. Polymorphisms in this gene, especially rs1344706, are thought to confer increased susceptibility to schizophrenia, bipolar disorder, and heroin addiciton. [provided by RefSeq, Nov 2015]

GeneCards Summary for ZNF804A Gene

ZNF804A (Zinc Finger Protein 804A) is a Protein Coding gene. Diseases associated with ZNF804A include bipolar disorder and psychotic disorder. An important paralog of this gene is ZNF804B.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF804A Gene

Genomics for ZNF804A Gene

Regulatory Elements for ZNF804A Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ZNF804A Gene

184,598,366 bp from pter
184,939,492 bp from pter
341,127 bases
Plus strand

Genomic View for ZNF804A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF804A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF804A Gene

Proteins for ZNF804A Gene

  • Protein details for ZNF804A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 804A
    Protein Accession:
    Secondary Accessions:
    • A7E253
    • Q6ZN26

    Protein attributes for ZNF804A Gene

    1209 amino acids
    Molecular mass:
    136888 Da
    Quaternary structure:
    • Interacts with ATXN1.

neXtProt entry for ZNF804A Gene

Proteomics data for ZNF804A Gene at MOPED

Selected DME Specific Peptides for ZNF804A Gene

Post-translational modifications for ZNF804A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF804A Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for ZNF804A Gene

Protein Domains for ZNF804A Gene

Suggested Antigen Peptide Sequences for ZNF804A Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 C2H2-type zinc finger.
  • Contains 1 C2H2-type zinc finger.
genes like me logo Genes that share domains with ZNF804A: view

No data available for Gene Families for ZNF804A Gene

Function for ZNF804A Gene

Enzyme Numbers (IUBMB) for ZNF804A Gene

Gene Ontology (GO) - Molecular Function for ZNF804A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF804A: view

Phenotypes for ZNF804A Gene

GenomeRNAi human phenotypes for ZNF804A:
genes like me logo Genes that share phenotypes with ZNF804A: view

Animal Model Products

CRISPR Products

miRNA for ZNF804A Gene

miRTarBase miRNAs that target ZNF804A

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF804A

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF804A Gene

Localization for ZNF804A Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for ZNF804A Gene

Pathways & Interactions for ZNF804A Gene

SuperPathways for ZNF804A Gene

No Data Available

Interacting Proteins for ZNF804A Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: Q7Z570-Z804A_HUMAN ENSP00000303252 for ZNF804A Gene via MINT I2D STRING

Gene Ontology (GO) - Biological Process for ZNF804A Gene


No data available for Pathways by source and SIGNOR curated interactions for ZNF804A Gene

Drugs & Compounds for ZNF804A Gene

(1) Drugs for ZNF804A Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
antipsychotics Pharma 0
genes like me logo Genes that share compounds with ZNF804A: view

Transcripts for ZNF804A Gene

mRNA/cDNA for ZNF804A Gene

(1) REFSEQ mRNAs :
(10) Additional mRNA sequences :
(24) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF804A Gene

Zinc finger protein 804A:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF804A

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF804A Gene

No ASD Table

Relevant External Links for ZNF804A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF804A Gene

mRNA expression in normal human tissues for ZNF804A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ZNF804A Gene

This gene is overexpressed in Brain - Anterior cingulate cortex (BA24) (x4.8), Brain - Hypothalamus (x4.8), Brain - Cerebellar Hemisphere (x4.8), Brain - Frontal Cortex (BA9) (x4.1), and Brain - Nucleus accumbens (basal ganglia) (x4.1).

Protein differential expression in normal tissues from HIPED for ZNF804A Gene

This gene is overexpressed in Liver (64.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF804A Gene

SOURCE GeneReport for Unigene cluster for ZNF804A Gene Hs.159528

genes like me logo Genes that share expression patterns with ZNF804A: view

Protein tissue co-expression partners for ZNF804A Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for ZNF804A Gene

Orthologs for ZNF804A Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF804A Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ZNF804A 35
  • 85.92 (n)
  • 79.27 (a)
ZNF804A 36
  • 77 (a)
(Mus musculus)
Mammalia Zfp804a 35
  • 77.36 (n)
  • 67.34 (a)
Zfp804a 16
Zfp804a 36
  • 64 (a)
(Pan troglodytes)
Mammalia ZNF804A 35
  • 99.28 (n)
  • 98.84 (a)
ZNF804A 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Zfp804a 35
  • 77.08 (n)
  • 66.08 (a)
(Canis familiaris)
Mammalia ZNF804A 36
  • 54 (a)
(Monodelphis domestica)
Mammalia ZNF804A 36
  • 59 (a)
(Ornithorhynchus anatinus)
Mammalia ZNF804A 36
  • 47 (a)
(Gallus gallus)
Aves ZNF804A 35
  • 61.21 (n)
  • 50.68 (a)
ZNF804A 36
  • 45 (a)
(Anolis carolinensis)
Reptilia ZNF804A 36
  • 46 (a)
(Danio rerio)
Actinopterygii znf804a 36
  • 27 (a)
Species with no ortholog for ZNF804A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF804A Gene

Gene Tree for ZNF804A (if available)
Gene Tree for ZNF804A (if available)

Paralogs for ZNF804A Gene

Paralogs for ZNF804A Gene

genes like me logo Genes that share paralogs with ZNF804A: view

Variants for ZNF804A Gene

Sequence variations from dbSNP and Humsavar for ZNF804A Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs181700 -- 184,604,376(+) caccg(G/T)gttag intron-variant
rs189644 -- 184,604,190(+) tttga(A/G)acgga intron-variant
rs359875 -- 184,616,921(+) CTTCA(A/G)TGGAC intron-variant
rs359881 -- 184,618,762(+) TACCT(A/C/G)GAAGT intron-variant
rs359882 -- 184,619,131(+) CAGAC(A/G)TTTGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF804A Gene

Variant ID Type Subtype PubMed ID
nsv875497 CNV Loss 21882294
dgv232n21 CNV Loss 19592680
nsv875512 CNV Loss 21882294
nsv834484 CNV Gain 17160897
nsv3069 CNV Insertion 18451855
esv2658623 CNV Deletion 23128226
esv1929674 CNV Deletion 18987734
nsv508189 CNV Loss 20534489
nsv520974 CNV Loss 19592680
nsv821846 CNV Gain 20364138
nsv818104 CNV Gain 17921354
nsv517466 CNV Gain 19592680
esv274639 CNV Insertion 20981092
esv270269 CNV Insertion 20981092

Variation tolerance for ZNF804A Gene

Residual Variation Intolerance Score: 69.77% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 25.20; 99.70% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF804A Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF804A Gene

Disorders for ZNF804A Gene

MalaCards: The human disease database

(3) MalaCards diseases for ZNF804A Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
bipolar disorder
  • major affective disorder 1
psychotic disorder
  • mental
  • schizophrenia 12
- elite association

Relevant External Links for ZNF804A

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with ZNF804A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF804A Gene

Publications for ZNF804A Gene

  1. High level of cannabinoid receptor 1, absence of regulator of G protein signalling 13 and differential expression of Cyclin D1 in mantle cell lymphoma. (PMID: 12970790) Islam T.C. … Sander B. (Leukemia 2003) 2 67
  2. ZNF804A genetic variation (rs1344706) affects brain grey but not white matter in schizophrenia and healthy subjects. (PMID: 25065377) Nenadic I. … Gaser C. (Psychol Med 2015) 67
  3. Expression of ZNF804A in human brain and alterations in schizophrenia, bipolar disorder, and major depressive disorder: a novel transcript fetally regulated by the psychosis risk variant rs1344706. (PMID: 25162540) Tao R. … Kleinman J.E. (JAMA Psychiatry 2014) 67
  4. How might ZNF804A variants influence risk for schizophrenia and bipolar disorder? A literature review, synthesis, and bioinformatic analysis. (PMID: 24123948) Hess J.L. … Glatt S.J. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2014) 67
  5. No effect of schizophrenia risk genes MIR137, TCF4, and ZNF804A on macroscopic brain structure. (PMID: 25217366) Cousijn H. … Arias-VA!squez A. (Schizophr. Res. 2014) 67

Products for ZNF804A Gene

Sources for ZNF804A Gene

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