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ZNF800 Gene

protein-coding   GIFtS: 47
GCID: GC07M126986

Zinc Finger Protein 800

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger Protein 8001 2

External Ids:    HGNC: 272671   Entrez Gene: 1688502   Ensembl: ENSG000000484057   UniProtKB: Q2TB103   

Export aliases for ZNF800 gene to outside databases

Previous GC identifers: GC07M126797 GC07M121371


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZNF800 Gene:
ZNF800 (zinc finger protein 800) is a protein-coding gene.

UniProtKB/Swiss-Prot: ZN800_HUMAN, Q2TB10
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000007.13  NT_007933.16  NC_018918.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZNF800 gene promoter:
         HFH-3   LUN-1   IRF-1   RORalpha2   FOXI1   FOXJ2 (long isoform)   FOXJ2   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): ZNF800 promoter sequence
   Search Chromatin IP Primers for ZNF800

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF800


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q31.33   Ensembl cytogenetic band:  7q31.33   HGNC cytogenetic band: 7q31.33

ZNF800 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF800 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M126986:  view genomic region     (about GC identifiers)

Start:
126,986,844 bp from pter      End:
127,071,978 bp from pter
Size:
85,135 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 126,393,790-126,416,193     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ZN800_HUMAN, Q2TB10 (See protein sequence)
Recommended Name: Zinc finger protein 800  
Size: 664 amino acids; 75236 Da
Sequence caution: Sequence=AAG17274.1; Type=Frameshift; Positions=335; Sequence=AAG17274.1; Type=Miscellaneous
discrepancy; Note=Contaminating sequence. Potential poly-A sequence;
Secondary accessions: Q9HBN0

Explore the universe of human proteins at neXtProt for ZNF800: NX_Q2TB10

Explore proteomics data for ZNF800 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ZNF800 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_789784.2  
    ENSEMBL proteins: 
     ENSP00000376989   ENSP00000265827   ENSP00000376988   ENSP00000403945   ENSP00000401109  
     ENSP00000389776  

    ZNF800 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for ZNF800

     
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    antibodies-online antibodies for ZNF800 (5 products) 

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    Cloud-Clone Corp. ELISAs for ZNF800
    Cloud-Clone Corp. CLIAs for ZNF800
    Search eBioscience for ELISAs for ZNF800 
    antibodies-online kits for ZNF800 (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    3 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q2TB10

    ProtoNet protein and cluster: Q2TB10

    UniProtKB/Swiss-Prot: ZN800_HUMAN, Q2TB10
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 7 C2H2-type zinc fingers


    Find genes that share domains with ZNF800           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN800_HUMAN, Q2TB10
    Function: May be involved in transcriptional regulation

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with ZNF800           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for ZNF800

    miRNA
    Products:
        
    miRTarBase miRNAs that target ZNF800:
    hsa-mir-101-3p (MIRT027358), hsa-mir-27a-3p (MIRT028743), hsa-mir-128-3p (MIRT022100), hsa-mir-335-5p (MIRT018402)

    Block miRNA regulation of human, mouse, rat ZNF800 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ZNF800 (see all 51):
    hsa-miR-140-5p hsa-miR-21* hsa-miR-520e hsa-miR-302d hsa-miR-520f hsa-miR-106a hsa-miR-624* hsa-miR-301a
    SwitchGear 3'UTR luciferase reporter plasmidZNF800 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ZNF800
    Predesigned siRNA for gene silencing in human, mouse, rat ZNF800

    Gene Editing
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    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF800

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF800


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZN800_HUMAN, Q2TB10: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol2
    plasma membrane1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    Find genes that share ontologies with ZNF800           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF800
    Interactions:

        Search GeneGlobe Interaction Network for ZNF800

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    Selected Interacting proteins for ZNF800 (Q2TB103 ENSP000002658274) via UniProtKB, MINT, STRING, and/or I2D (see all 18)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CSNK2BP678703I2D: score=5 
    ENSG00000206406P678703I2D: score=5 
    ENSG00000224398P678703I2D: score=5 
    ENSG00000224774P678703I2D: score=5 
    ENSG00000228875P678703I2D: score=5 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--

    Find genes that share ontologies with ZNF800           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZNF800 (ZN800)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ZNF800 gene: 
    NM_176814.3  

    Unigene Cluster for ZNF800:

    Zinc finger protein 800
    Hs.159006  [show with all ESTs]
    Unigene Representative Sequence: NM_176814
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000485577 ENST00000393313 ENST00000265827(uc003vlw.1 uc003vlx.1 uc003vly.1 uc010lla.2)
    ENST00000393312 ENST00000434602 ENST00000436992 ENST00000439506
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ZNF800 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ZNF800 (see all 51):
    hsa-miR-140-5p hsa-miR-21* hsa-miR-520e hsa-miR-302d hsa-miR-520f hsa-miR-106a hsa-miR-624* hsa-miR-301a
    SwitchGear 3'UTR luciferase reporter plasmidZNF800 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ZNF800
    Predesigned siRNA for gene silencing in human, mouse, rat ZNF800
    Clone
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    GenScript: all cDNA clones in your preferred vector: ZNF800 (NM_176814)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ZNF800
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF800
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for ZNF800
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ZNF800
      QuantiTect SYBR Green Assays in human, mouse, rat ZNF800
      QuantiFast Probe-based Assays in human, mouse, rat ZNF800

    Additional mRNA sequence: 

    AF218032.1 AK125291.1 AK297946.1 AK309674.1 BC037348.1 BC047641.1 BC110623.1 BC110624.1 
    DQ655936.2 

    7 DOTS entries:

    DT.75101931  DT.40207154  DT.101962147  DT.100738486  DT.101980592  DT.40201794  DT.95150469 

    Selected AceView cDNA sequences (see all 114):

    AL042740 AA721676 BG112338 AI351384 AA283049 BM761183 BM469460 AA811296 
    AA485859 AA973112 AW059674 AI076890 NM_176814 BM761051 BF434229 CR611240 
    BF063962 AI632745 AA588543 AI078083 AI478171 BU581251 AA485723 AI400331 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF800    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6
    SP1:                    -                                       
    SP2:                    -                                       
    SP3:                                                            


    ECgene alternative splicing isoforms for ZNF800

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZNF800 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTCTTGTTGG
    ZNF800 Expression
    About this image

    ZNF800 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZNF800 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.159006
        Custom PCR Arrays for ZNF800
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF800

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ZNF800 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfp8001 , 5 zinc finger protein 8001, 5 93.39(n)1
    94.86(a)1
      6 (11.99 cM)5
    6270491  NM_001081678.11  NP_001075147.11 
     282399315 
    chicken
    (Gallus gallus)
    Aves ZNF8001 zinc finger protein 800 83.99(n)
    85.69(a)
      417747  NM_001199499.1  NP_001186428.1 
    lizard
    (Anolis carolinensis)
    Reptilia ZNF8006
    zinc finger protein 800
    70(a)
    1 ↔ 1
    5(65063431-65071582)
    African clawed frog
    (Xenopus laevis)
    Amphibia BJ068877.12   -- 81.64(n)    BJ068877.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC054916.12   -- 73.56(n)   393408  BC054916.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG109796
    --
    15(a)
    1 ↔ 1
    3R(1620426-1624348)


    ENSEMBL Gene Tree for ZNF800 (if available)
    TreeFam Gene Tree for ZNF800 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZNF800 (see all 548)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs178653791,2
    H--127009919(+) TCTATA/CGTATT 1 -- int14Minor allele frequency- C:0.00NS EA 418
    rs178684871,2
    H--127010112(+) CATATA/CGGTTT 1 -- int14Minor allele frequency- C:0.00NS EA 416
    rs178670241,2
    C,F,H--127010124(+) ATAATG/ATGCAA 1 -- int14Minor allele frequency- A:0.02EA NS WA 416
    rs1438794031,2
    --127010213(+) TTAGAG/TCTATA 1 -- int10--------
    rs50223211,2
    H--127010324(+) GTGTAG/CCTGCT 1 -- int12Minor allele frequency- C:0.00NS 236
    rs178672031,2
    C,F--127010327(+) TAGCTG/TCTCAT 1 -- int13Minor allele frequency- T:0.03NA WA 122
    rs178623671,2
    C,F,H--127010336(+) ATAGTC/AACTGA 1 -- int111Minor allele frequency- A:0.06NS EA NA 1590
    rs1881316301,2
    --127010444(+) ATCACA/TTATAG 1 -- ut310--------
    rs1824027091,2
    C--127010494(+) CATTTC/TCAGCA 1 -- ut310--------
    rs1486067351,2
    --127010516(+) CTTTCC/TAGTTT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for ZNF800 (126986844 - 127071978 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for ZNF800:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv820163CNV Gain19587683

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ZNF800
    DNA2.0 Custom Variant and Variant Library Synthesis for ZNF800

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with ZNF800           About GenesLikeMe

    Genetic Association Database (GAD): ZNF800

    Export disorders for ZNF800 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZNF800 gene, integrated from 10 sources (see all 15):
    (articles sorted by number of sources associating them with ZNF800)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    2. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    3. Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians. (PubMed id 22158537)4 Cho Y.S....Seielstad M. (Nat. Genet. 2012)
    4. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    5. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (Sci. Signal. 2010)
    6. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (EMBO J. 2009)
    7. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    8. Structured RNAs in the ENCODE selected regions of the human genome. (PubMed id 17568003)1 Washietl S....Stadler P.F. (Genome Res. 2007)
    9. Genome-wide association to body mass index and waist circumference: the Framingham Heart Study 100K project. (PubMed id 17903300)4 Fox C.S....Atwood L.D. (BMC Med. Genet. 2007)
    10. Prominent use of distal 5' transcription start sites and discovery of a large number of additional exons in ENCODE regions. (PubMed id 17567994)1 Denoeud F....Reymond A. (Genome Res. 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 168850 HGNC: 27267 AceView: LOC168850 Ensembl:ENSG00000048405 euGenes: HUgn168850
    ECgene: ZNF800 H-InvDB: ZNF800

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZNF800 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZNF800 gene:
    Search GeneIP for patents involving ZNF800

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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