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Aliases for ZNF8 Gene

Aliases for ZNF8 Gene

  • Zinc Finger Protein 8 2 3 5
  • Zinc Finger Protein 8 (Clone HF.18) 2 3
  • Zinc Finger Protein HF.18 3 4
  • Zinc Finger Protein 272 3
  • Zfp128 3
  • HF.18 3

External Ids for ZNF8 Gene

Previous GeneCards Identifiers for ZNF8 Gene

  • GC19P059695
  • GC19P059244
  • GC19P063466
  • GC19P063482
  • GC19P058790
  • GC19P055099

Summaries for ZNF8 Gene

GeneCards Summary for ZNF8 Gene

ZNF8 (Zinc Finger Protein 8) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF514.

UniProtKB/Swiss-Prot for ZNF8 Gene

  • May be involved in transcriptional regulation.

Gene Wiki entry for ZNF8 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF8 Gene

Genomics for ZNF8 Gene

Regulatory Elements for ZNF8 Gene

Enhancers for ZNF8 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZNF8 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF8 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF8 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF8 Gene

58,278,951 bp from pter
58,302,805 bp from pter
23,855 bases
Plus strand

Genomic View for ZNF8 Gene

Genes around ZNF8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF8 Gene

Proteins for ZNF8 Gene

  • Protein details for ZNF8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 8
    Protein Accession:
    Secondary Accessions:
    • Q6PI99

    Protein attributes for ZNF8 Gene

    575 amino acids
    Molecular mass:
    64970 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF8 Gene

Proteomics data for ZNF8 Gene at MOPED

Post-translational modifications for ZNF8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF8 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF8 Gene

Domains & Families for ZNF8 Gene

Gene Families for ZNF8 Gene

Protein Domains for ZNF8 Gene

Suggested Antigen Peptide Sequences for ZNF8 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 7 C2H2-type zinc fingers.
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 7 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF8: view

Function for ZNF8 Gene

Molecular function for ZNF8 Gene

GENATLAS Biochemistry:
zinc finger protein 8 (clone ZFP.18) (C2H2,Kruppel-like)
UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with ZNF8: view
genes like me logo Genes that share phenotypes with ZNF8: view

Animal Model Products

CRISPR Products

miRNA for ZNF8 Gene

miRTarBase miRNAs that target ZNF8

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF8 Gene

Localization for ZNF8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF8 Gene

Subcellular locations from

Jensen Localization Image for ZNF8 Gene COMPARTMENTS Subcellular localization image for ZNF8 gene
Compartment Confidence
nucleus 5
cytosol 3

No data available for Gene Ontology (GO) - Cellular Components for ZNF8 Gene

Pathways & Interactions for ZNF8 Gene

SuperPathways for ZNF8 Gene

No Data Available

Interacting Proteins for ZNF8 Gene

Selected Interacting proteins: P17098-ZNF8_HUMAN for ZNF8 Gene via I2D

Gene Ontology (GO) - Biological Process for ZNF8 Gene


No data available for Pathways by source and SIGNOR curated interactions for ZNF8 Gene

Drugs & Compounds for ZNF8 Gene

No Compound Related Data Available

Transcripts for ZNF8 Gene

mRNA/cDNA for ZNF8 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(253) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF8 Gene

Zinc finger protein 8:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF8 Gene

No ASD Table

Relevant External Links for ZNF8 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF8 Gene

mRNA expression in normal human tissues for ZNF8 Gene

Protein differential expression in normal tissues from HIPED for ZNF8 Gene

This gene is overexpressed in Heart (30.7), Islet of Langerhans (15.9), and Saliva (13.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for ZNF8 Gene

SOURCE GeneReport for Unigene cluster for ZNF8 Gene Hs.590941

mRNA Expression by UniProt/SwissProt for ZNF8 Gene

Tissue specificity: Ubiquitously present in many human cell lines of different embryological derivation.
genes like me logo Genes that share expression patterns with ZNF8: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein tissue co-expression partners for ZNF8 Gene

Orthologs for ZNF8 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF8 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia ZNF8 35
  • 83.28 (n)
  • 81.88 (a)
(Mus musculus)
Mammalia Zfp128 35
  • 79.09 (n)
  • 74.17 (a)
Zfp128 16
(Pan troglodytes)
Mammalia ZNF8 35
  • 99.25 (n)
  • 99.13 (a)
(Rattus norvegicus)
Mammalia LOC102553002 35
  • 79.02 (n)
  • 75.52 (a)
Species with no ortholog for ZNF8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF8 Gene

Gene Tree for ZNF8 (if available)
Gene Tree for ZNF8 (if available)

Paralogs for ZNF8 Gene

Paralogs for ZNF8 Gene

(375) SIMAP similar genes for ZNF8 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ZNF8: view

Variants for ZNF8 Gene

Sequence variations from dbSNP and Humsavar for ZNF8 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs7258422 -- 58,292,405(+) agaga(C/G)aggaa intron-variant
rs8104061 -- 58,284,620(+) gaggc(A/G)ggtgg intron-variant
rs12986027 -- 58,282,230(+) taatg(A/G)tgttg intron-variant
rs8105044 -- 58,285,439(+) gttta(C/G)gccag intron-variant
rs67853886 -- 58,285,157(+) TTTTT(-/T)GAGAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF8 Gene

Variant ID Type Subtype PubMed ID
nsv833886 CNV Gain 17160897
nsv912537 CNV Loss 21882294
nsv833887 CNV Loss 17160897

Variation tolerance for ZNF8 Gene

Residual Variation Intolerance Score: 70.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.08; 22.08% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ZNF8 Gene

Disorders for ZNF8 Gene

Relevant External Links for ZNF8

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZNF8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF8 Gene

Publications for ZNF8 Gene

  1. cDNA isolation, expression analysis, and chromosomal localization of two human zinc finger genes. (PMID: 2106481) Lania L. … Pelicci P.-G. (Genomics 1990) 2 3 4 67
  2. Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes. (PMID: 25281560) Lambert J.P. … Gingras A.C. (J Proteomics 2015) 3
  3. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 3
  4. Maintenance of silent chromatin through replication requires SWI/SNF- like chromatin remodeler SMARCAD1. (PMID: 21549307) Rowbotham S.P. … Mermoud J.E. (Mol. Cell 2011) 3
  5. Analysis of the human HP1 interactome reveals novel binding partners. (PMID: 21888893) Rosnoblet C. … Angrand P.O. (Biochem. Biophys. Res. Commun. 2011) 3

Products for ZNF8 Gene

Sources for ZNF8 Gene