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Aliases for ZNF8 Gene

Aliases for ZNF8 Gene

  • Zinc Finger Protein 8 2 3
  • Zinc Finger Protein 8 (Clone HF.18) 2 3
  • Zinc Finger Protein HF.18 3 4
  • Zinc Finger Protein 272 3
  • Zfp128 3
  • HF.18 3

External Ids for ZNF8 Gene

Previous GeneCards Identifiers for ZNF8 Gene

  • GC19P059695
  • GC19P059244
  • GC19P063466
  • GC19P063482
  • GC19P058790
  • GC19P055099

Summaries for ZNF8 Gene

GeneCards Summary for ZNF8 Gene

ZNF8 (Zinc Finger Protein 8) is a Protein Coding gene.

UniProtKB/Swiss-Prot for ZNF8 Gene

  • May be involved in transcriptional regulation

Gene Wiki entry for ZNF8 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF8 Gene

Genomics for ZNF8 Gene

Regulatory Elements for ZNF8 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ZNF8 Gene

Start:
58,278,951 bp from pter
End:
58,302,805 bp from pter
Size:
23,855 bases
Orientation:
Plus strand

Genomic View for ZNF8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF8 Gene

Proteins for ZNF8 Gene

  • Protein details for ZNF8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P17098-ZNF8_HUMAN
    Recommended name:
    Zinc finger protein 8
    Protein Accession:
    P17098
    Secondary Accessions:
    • Q6PI99

    Protein attributes for ZNF8 Gene

    Size:
    575 amino acids
    Molecular mass:
    64970 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF8 Gene

Proteomics data for ZNF8 Gene at MOPED

Post-translational modifications for ZNF8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF8 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF8 Gene

Domains for ZNF8 Gene

Gene Families for ZNF8 Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type

Suggested Antigen Peptide Sequences for ZNF8 Gene

Graphical View of Domain Structure for InterPro Entry

P17098

UniProtKB/Swiss-Prot:

ZNF8_HUMAN :
  • P17098
Domain:
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 7 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF8: view

Function for ZNF8 Gene

Molecular function for ZNF8 Gene

GENATLAS Biochemistry: zinc finger protein 8 (clone ZFP.18) (C2H2,Kruppel-like)
UniProtKB/Swiss-Prot Function: May be involved in transcriptional regulation

Gene Ontology (GO) - Molecular Function for ZNF8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding NAS 2106481
GO:0005515 protein binding --
GO:0008270 zinc ion binding NAS 2106481
GO:0046872 metal ion binding --
genes like me logo Genes that share ontologies with ZNF8: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF8

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ZNF8 Gene

Localization for ZNF8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF8 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF8 Gene COMPARTMENTS Subcellular localization image for ZNF8 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF8: view

Pathways for ZNF8 Gene

SuperPathways for ZNF8 Gene

No Data Available

Interacting Proteins for ZNF8 Gene

Selected Interacting proteins: P17098-ZNF8_HUMAN for ZNF8 Gene via I2D

Gene Ontology (GO) - Biological Process for ZNF8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated --
GO:0030509 BMP signaling pathway IEA --
genes like me logo Genes that share ontologies with ZNF8: view

No data available for Pathways by source for ZNF8 Gene

Transcripts for ZNF8 Gene

mRNA/cDNA for ZNF8 Gene

(253) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF8 Gene

Zinc finger protein 8:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF8

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for ZNF8

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF8 Gene

No ASD Table

Relevant External Links for ZNF8 Gene

GeneLoc Exon Structure for
ZNF8
ECgene alternative splicing isoforms for
ZNF8

Expression for ZNF8 Gene

mRNA expression in normal human tissues for ZNF8 Gene

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for ZNF8 Gene

SOURCE GeneReport for Unigene cluster for ZNF8 Gene Hs.590941

mRNA Expression by UniProt/SwissProt for ZNF8 Gene

P17098-ZNF8_HUMAN
Tissue specificity: Ubiquitously present in many human cell lines of different embryological derivation.
genes like me logo Genes that share expressions with ZNF8: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for ZNF8 Gene

Orthologs for ZNF8 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF8 35
  • 99.25 (n)
  • 99.13 (a)
dog
(Canis familiaris)
Mammalia ZNF8 35
  • 83.28 (n)
  • 81.88 (a)
mouse
(Mus musculus)
Mammalia Zfp128 35
  • 79.09 (n)
  • 74.17 (a)
Zfp128 16
rat
(Rattus norvegicus)
Mammalia LOC102553002 35
  • 79.02 (n)
  • 75.52 (a)
Species with no ortholog for ZNF8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF8 Gene

ENSEMBL:
Gene Tree for ZNF8 (if available)
TreeFam:
Gene Tree for ZNF8 (if available)

Paralogs for ZNF8 Gene

Selected SIMAP similar genes for ZNF8 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ZNF8: view

No data available for Paralogs for ZNF8 Gene

Variants for ZNF8 Gene

Sequence variations from dbSNP and Humsavar for ZNF8 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs260470 -- 58,293,447(+) AGGTG(G/T)ACCCA intron-variant
rs260471 -- 58,294,717(-) CGCTC(A/G)TGCTG synonymous-codon, reference
rs260473 -- 58,286,771(+) CTGGT(C/T)TCAGG intron-variant
rs260474 -- 58,286,934(+) TCATT(C/T)CCTCT intron-variant
rs260475 -- 58,287,124(+) agcct(C/T)gacct intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF8 Gene

Variant ID Type Subtype PubMed ID
nsv833886 CNV Gain 17160897
nsv912537 CNV Loss 21882294
nsv833887 CNV Loss 17160897

Relevant External Links for ZNF8 Gene

HapMap Linkage Disequilibrium report
ZNF8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF8 Gene

Disorders for ZNF8 Gene

No disorders were found for ZNF8 Gene.

No data available for UniProtKB/Swiss-Prot for ZNF8 Gene

Publications for ZNF8 Gene

  1. cDNA isolation, expression analysis, and chromosomal localization of two human zinc finger genes. (PMID: 2106481) Lania L. … Pelicci P.-G. (Genomics 1990) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil S.A. … Gygi S.P. (Nat. Biotechnol. 2006) 3
  4. Systematic analysis of human protein complexes identifies chromosome segregation proteins. (PMID: 20360068) Hutchins J.R. … Peters J.M. (Science 2010) 3
  5. Human POGZ modulates dissociation of HP1alpha from mitotic chromosome arms through Aurora B activation. (PMID: 20562864) Nozawa R.S. … Obuse C. (Nat. Cell Biol. 2010) 3

Products for ZNF8 Gene

Sources for ZNF8 Gene

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