ZNF8 Gene
protein-coding GIFtS: 47
GCID: GC19P058790
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zinc finger protein 8(Previous name: zinc finger protein 8 (clone HF.18) )
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Aliases
for ZNF8 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger Protein 81 2 | | HF.181 2 | | Zfp1281 2 | | Zinc Finger Protein 8 (Clone HF.18)1 2 | | Zinc Finger Protein HF.182 3 | | Zinc Finger Protein 2722 |
Export aliases for ZNF8 gene to outside databasesPrevious GC identifers: GC19P059695 GC19P059244 GC19P063466 GC19P063482 GC19P055099 |
Summaries
for ZNF8 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: ZNF8_HUMAN, P17098Function: May be involved in transcriptional regulation
Gene Wiki entry for ZNF8
|
Genomic Views
for ZNF8 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011109.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZNF8 gene promoter:
Pbx1a Zic1 Sox9 Pax-2 Pax-2a STAT5A NF-Y CBF(2)
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZNF8
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF8 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19q13.43 Ensembl cytogenetic band: 19q13.43 HGNC cytogenetic band: 19q13.43ZNF8 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P058790: view genomic region
(about GC identifiers)
Start:
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58,790,317 bp from pter |
End:
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58,807,254 bp from pter |
Size:
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16,938 bases |
Orientation:
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plus strand |
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Proteins
for ZNF8 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZNF8_HUMAN, P17098 (See
protein sequence)Recommended Name: Zinc finger protein 8 Size: 575 amino acids; 64970 Da
Subcellular location: Nucleus (Probable)
Secondary accessions: Q6PI99Explore the universe of human proteins at neXtProt for ZNF8: NX_P17098
Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P17098
ZNF8 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_066575.2
ENSEMBL proteins: ENSP00000196548
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
NAS | -- |
ZNF8 for ontologies About GeneDecksing
ZNF8 Antibody Products:
Assay Products for ZNF8: |
Protein
Domains /
Families
for ZNF8 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZNF8 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P17098ProtoNet protein and cluster: P17098 2 Blocks protein families: IPB001909 KRAB box IPB007086 C2H2-type zinc finger signature
UniProtKB/Swiss-Prot: ZNF8_HUMAN, P17098Similarity: Belongs to the krueppel C2H2-type zinc-finger protein familySimilarity: Contains 7 C2H2-type zinc fingersSimilarity: Contains 1 KRAB domain |
Function
for ZNF8 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ZNF8_HUMAN, P17098Function: May be involved in transcriptional regulation Genatlas biochemistry entry for ZNF8:zinc finger protein 8 (clone ZFP.18) (C2H2,Kruppel-like)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF8 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF8
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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| |  | GenScript: all cDNA clones in your preferred vector: ZNF8 (NM_021089) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF8 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF8 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF8 |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
ZNF8 for ontologies About GeneDecksing
|
Pathways & Interactions
for ZNF8 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF8
STRING Interaction
Network Preview (showing 5 interactants - click image to see 8)
5/9 Interacting proteins for ZNF8 (P170983 ENSP000001965484) via UniProtKB, MINT, STRING, and/or I2D (see all 9)About this table
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000122 | negative regulation of transcription from RNA polymerase II promoter |
IEA | -- | | GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
NAS | -- | | GO:0030509 | BMP signaling pathway |
IEA | -- |
ZNF8 for ontologies About GeneDecksing
|
Drugs & Compounds
for ZNF8 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZNF8
Search CenterWatch for drugs/clinical trials and news about ZNF8
|
Transcripts
for ZNF8 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZNF8 gene: NM_021089.2 Unigene Clusters for ZNF8: Zinc finger protein 8 Hs.590941 [show with all ESTs], Hs.713519 Unigene Representative Sequences: AK225825, AK2997161 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000196548(uc002qry.1 uc002qrz.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF8 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF8
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ZNF8 (NM_021089) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF8 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF8 |
Additional cDNA sequence: AK299716.1 4 DOTS entries: DT.99955168 DT.40106242 DT.422120 DT.91755868 24/253 AceView cDNA sequences (see all 253): BU507738 AW518178 AI023419 AA557252 BM710953 BQ224422 BP431087 AX747928 AA946658 CN482722 AW162774 BU838911 BM352593 BU789862 AW162665 BC039323 AV708502 AI597719 BM725035 AA603338 BP367623 BM565592 BQ026811 BQ684259
GeneLoc Exon Structure
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Expression
for ZNF8 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZNF8 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGTGACTTCT
About this image
See ZNF8 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZNF8
SOURCE GeneReport for Unigene clusters: Hs.590941 Hs.713519
UniProtKB/Swiss-Prot: ZNF8_HUMAN, P17098Tissue specificity: Ubiquitously present in many human cell lines of different embryological derivation
SABiosciences Custom PCR Arrays for ZNF8
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF8
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ZNF8 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF8 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF8 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF8 |
Orthologs
for ZNF8 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for ZNF8 (if available)
TreeFam Gene Tree for ZNF8 (if available) |
Paralogs
for ZNF8 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ZNF8 gene
- ZNF5702 ZNF2872 ZNF1812 ZFP282 ZNF4712 ZNF72 ZNF2502 ZNF8792
- ZNF3022 ZNF354C2 ZNF742 ZNF5832 ZFP902 ZNF1892 ZNF354A2 ZNF354B2
- ZNF1352 ZNF5682 ZNF342 ZNF5272 ZNF5692 ZNF4702
18/392 SIMAP similar genes for ZNF8 using alignment to 1 protein entry: ZNF8_HUMAN(see all similar genes):ZNF78L1 ZFP41 ZKSCAN1 ZNF22 ZFS-2 ZNF781
ZNF844 ZSCAN30 ZNF DKFZp434J0650 ZNF72 HZF36
ZNF323 ZNF702P ZSCAN29 DKFZp666C237 ZNF32 ZNF833P
ZNF8 for paralogs About GeneDecksing
|
Genomic Variants
for ZNF8 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZNF8 (58790317 - 58807254 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ZNF8: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF8 |
|
Disorders
/ Diseases
for ZNF8 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 ZNF8 for disorders About MalaCards
ZNF8 for disorders About GeneDecksing
OMIM gene information: 194532
OMIM disorders: --
Export disorders for ZNF8 gene to outside databases
|
Publications
for ZNF8 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZNF8 gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with ZNF8) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- cDNA isolation, expression analysis, and chromosomal localization of two human zinc finger genes. (PubMed id 2106481)1, 2, 3 Lania L.... Pelicci P.-G. (1990)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Maintenance of silent chromatin through replication r equires SWI/SNF-like chromatin remodeler SMARCAD1. (PubMed id 21549307)1 Rowbotham S.P....Mermoud J.E. (2011)
- Analysis of the human HP1 interactome reveals novel bi nding partners. (PubMed id 21888893)1 Rosnoblet C....Angrand P.O. (2011)
- Systematic analysis of human protein complexes identi fies chromosome segregation proteins. (PubMed id 20360068)1 Hutchins J.R....Peters J.M. (2010)
- Human POGZ modulates dissociation of HP1alpha from mi totic chromosome arms through Aurora B activation. (PubMed id 20562864)1 Nozawa R.S....Obuse C. (2010)
- A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1 Beausoleil S.A.... Gygi S.P. (2006)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
- Identification of mZnf8, a mouse Kruppel-like transcriptional repressor, as a novel nuclear interaction partner of Smad1. (PubMed id 12370310)1 Jiao K....Hogan B.L. (2002)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for ZNF8 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing ZNF8 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZNF8 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZNF8 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZNF8 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for ZNF8 gene:
Search GeneIP for patents involving ZNF8
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZNF8 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | Browse OriGene shRNA RFPs | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZNF8 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF8 | | | OriGene Protein Over-expression Lysate for ZNF8 | | Browse OriGene Fluorogenic Cell Assay Kits | | | Browse OriGene siRNAs | | OriGene 3'-UTR Clone for ZNF8 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF8 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF8 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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 | | | ZNF8 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF8 |
|  |  |  | | | | ThermoFisher Antibodies for ZNF8 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF8 |
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