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ZNF8 Gene

protein-coding   GIFtS: 45
GCID: GC19P058790

Zinc Finger Protein 8

(Previous name: zinc finger protein 8 (clone HF.18))
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger Protein 81 2
Zinc Finger Protein 8 (Clone HF.18)1 2
Zinc Finger Protein HF.182 3
HF.182
Zfp1282
Zinc Finger Protein 2722

External Ids:    HGNC: 131541   Entrez Gene: 75542   Ensembl: ENSG000002734397   OMIM: 1945325   UniProtKB: P170983   

Export aliases for ZNF8 gene to outside databases

Previous GC identifers: GC19P059695 GC19P059244 GC19P063466 GC19P063482 GC19P055099


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZNF8 Gene:
ZNF8 (zinc finger protein 8) is a protein-coding gene. An important paralog of this gene is GFI1.

UniProtKB/Swiss-Prot: ZNF8_HUMAN, P17098
Function: May be involved in transcriptional regulation

Gene Wiki entry for ZNF8 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NC_018930.2  NT_011109.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZNF8 gene promoter:
         Pbx1a   Zic1   Sox9   Pax-2   Pax-2a   STAT5A   NF-Y   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF8 promoter sequence
   Search Chromatin IP Primers for ZNF8

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.43   Ensembl cytogenetic band:  19q13.43   HGNC cytogenetic band: 19q13.43

ZNF8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF8 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P058790:  view genomic region     (about GC identifiers)

Start:
58,790,318 bp from pter      End:
58,807,254 bp from pter
Size:
16,937 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ZNF8_HUMAN, P17098 (See protein sequence)
Recommended Name: Zinc finger protein 8  
Size: 575 amino acids; 64970 Da
Secondary accessions: Q6PI99

Explore the universe of human proteins at neXtProt for ZNF8: NX_P17098

Explore proteomics data for ZNF8 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ZNF8 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_066575.2  
    ENSEMBL proteins: 
     ENSP00000476449  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR001909 Krueppel-associated_box
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry P17098

    ProtoNet protein and cluster: P17098

    2 Blocks protein domains:
    IPB001909 KRAB box
    IPB007086 C2H2-type zinc finger signature


    UniProtKB/Swiss-Prot: ZNF8_HUMAN, P17098
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 7 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    Find genes that share domains with ZNF8           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZNF8_HUMAN, P17098
    Function: May be involved in transcriptional regulation

         Genatlas biochemistry entry for ZNF8:
    zinc finger protein 8 (clone ZFP.18) (C2H2,Kruppel-like)

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding NAS2106481
    GO:0008270zinc ion binding NAS2106481
    GO:0046872metal ion binding ----
         
    Find genes that share ontologies with ZNF8           About GenesLikeMe


    Animal Models:
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZNF8_HUMAN, P17098: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--

    Find genes that share ontologies with ZNF8           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF8
    Interactions:

        Search GeneGlobe Interaction Network for ZNF8

    5 Interacting proteins for ZNF8 (P170983) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMAD1Q157973I2D: score=1 
    SMAD2Q157963I2D: score=1 
    SMAD3P840223I2D: score=1 
    SMAD4Q134853I2D: score=1 
    SMAD5Q997173I2D: score=1 
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter ----
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--
    GO:0030509BMP signaling pathway ----

    Find genes that share ontologies with ZNF8           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZNF8



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ZNF8 gene: 
    NM_021089.2  

    Unigene Cluster for ZNF8:

    Zinc finger protein 8
    Hs.590941  [show with all ESTs]
    Unigene Representative Sequence: AK225825
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000608843
    miRNA
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    Additional mRNA sequence: 

    AK093110.1 AK225825.1 BC039323.1 M29581.1 

    4 DOTS entries:

    DT.99955168  DT.40106242  DT.422120  DT.91755868 

    Selected AceView cDNA sequences (see all 253):

    NM_021089 AV708502 AA902358 BU838911 AW162774 AI017900 BM800060 BU166526 
    AK093110 AX747928 AA603338 BM695659 AW005336 CN482722 BX109278 AA860817 
    BQ001150 BM352593 AW162665 BM680245 BC039323 AK128657 AI023419 BP431087 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZNF8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGTGACTTCT
    ZNF8 Expression
    About this image

    ZNF8 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZNF8 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.590941

    UniProtKB/Swiss-Prot: ZNF8_HUMAN, P17098
    Tissue specificity: Ubiquitously present in many human cell lines of different embryological derivation

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ZNF8 gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfp1281 , 5 zinc finger protein 1281, 5 79.09(n)1
    74.17(a)1
      7 (7.67 cM)5
    2438331  NM_153802.41  NP_722497.11 
     128811775 
    zebrafish
    (Danio rerio)
    Actinopterygii gfi1aa6
    growth factor independent 1aa
    24(a)
    many ↔ many
    2(10558049-10576954) ENSDARG00000020746
    fruit fly
    (Drosophila melanogaster)
    Insecta sens6
    senseless
    14(a)
    many ↔ many
    3L(13389328-13394225)


    ENSEMBL Gene Tree for ZNF8 (if available)
    TreeFam Gene Tree for ZNF8 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZNF8 gene
    GFI12  GFI1B2  FEZF12  FEZF22  
    Selected SIMAP similar genes for ZNF8 using alignment to 1 protein entry:     ZNF8_HUMAN(see all similar genes):
    ZNF78L1    ZFP41    ZKSCAN1    ZNF22    ZFS-2    ZNF781
    ZNF844    ZSCAN30    ZNF    DKFZp434J0650    ZNF72    HZF36
    ZNF323    ZNF702P    ZSCAN29    DKFZp666C237    ZNF32    ZNF833P

    Find genes that share paralogs with ZNF8           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZNF8 (see all 491)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs21686441,2
    C,F,A,H--58788393(+) GGATCT/CACCTG 1 -- us2k118Minor allele frequency- C:0.19NS EA NA WA CSA 1208
    rs1858648651,2
    --58788443(+) TGACTC/GTGTCT 1 -- us2k10--------
    rs1902923311,2
    --58788544(+) TCCTTC/TTCAGG 1 -- us2k10--------
    rs1453514291,2
    --58788552(+) AGGAAC/TGAGGC 1 -- us2k10--------
    rs1425830761,2
    --58788575(+) AGAGAC/TGGTAC 1 -- us2k10--------
    rs1825646321,2
    --58788580(+) CGGTAC/TAGGGC 1 -- us2k10--------
    rs1122115991,2
    C,F--58788657(+) TGTGGC/ACAGCT 1 -- us2k12Minor allele frequency- A:0.07WA 120
    rs786754221,2
    C--58788673(+) CCCTCG/AGGAGT 1 -- us2k11Minor allele frequency- A:0.50WA 2
    rs768016371,2
    C,F--58788784(+) CCATGG/AGGGTG 1 -- us2k11Minor allele frequency- A:0.02NA 120
    rs739418041,2
    C,F--58788827(+) TATGTG/ATCTGG 1 -- us2k11Minor allele frequency- A:0.50WA 2

    HapMap Linkage Disequilibrium report for ZNF8 (58790318 - 58807254 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for ZNF8:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv833887CNV Loss17160897
    nsv912537CNV Loss21882294
    nsv833886CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 194532    OMIM disorders: --


    Find genes that share disorders with ZNF8           About GenesLikeMe


    Export disorders for ZNF8 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZNF8 gene, integrated from 10 sources (see all 12):
    (articles sorted by number of sources associating them with ZNF8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. cDNA isolation, expression analysis, and chromosomal localization of two human zinc finger genes. (PubMed id 2106481)1, 2, 3 Lania L.... Pelicci P.-G. (Genomics 1990)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    4. Maintenance of silent chromatin through replication requires SWI/SNF- like chromatin remodeler SMARCAD1. (PubMed id 21549307)1 Rowbotham S.P.... Mermoud J.E. (Mol. Cell 2011)
    5. Analysis of the human HP1 interactome reveals novel binding partners. (PubMed id 21888893)1 Rosnoblet C....Angrand P.O. (Biochem. Biophys. Res. Commun. 2011)
    6. Systematic analysis of human protein complexes identifies chromosome segregation proteins. (PubMed id 20360068)1 Hutchins J.R.... Peters J.M. (Science 2010)
    7. Human POGZ modulates dissociation of HP1alpha from mitotic chromosome arms through Aurora B activation. (PubMed id 20562864)1 Nozawa R.S.... Obuse C. (Nat. Cell Biol. 2010)
    8. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1 Beausoleil S.A.... Gygi S.P. (Nat. Biotechnol. 2006)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (Nat. Genet. 2004)
    10. Identification of mZnf8, a mouse KrA1ppel-like transcriptional repressor, as a novel nuclear interaction partner of Smad1. (PubMed id 12370310)1 Jiao K....Hogan B.L. (Mol. Cell. Biol. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7554 HGNC: 13154 AceView: ZNF8 Ensembl:ENSG00000273439 euGenes: HUgn7554
    ECgene: ZNF8 H-InvDB: ZNF8

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZNF8 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZNF8 gene:
    Search GeneIP for patents involving ZNF8

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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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