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ZNF799 Gene

protein-coding   GIFtS: 44
GCID: GC19M012500

Zinc Finger Protein 799

(Previous name: zinc finger protein 842)
(Previous symbol: ZNF842)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger Protein 7991 2     Protein For MGC718052
Zinc Finger Protein 8421 2 3     Zinc Finger Protein 142
ZNF8421 2 3     Zinc Finger Protein HIT-402
HIT-402     

External Ids:    HGNC: 280711   Entrez Gene: 905762   Ensembl: ENSG000001964667   UniProtKB: Q96GE53   

Export aliases for ZNF799 gene to outside databases

Previous GC identifers: GC19M012353 GC19M012492 GC19M012075


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZNF799 Gene:
ZNF799 (zinc finger protein 799) is a protein-coding gene. An important paralog of this gene is ZNF669.

UniProtKB/Swiss-Prot: ZN799_HUMAN, Q96GE5
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NC_018930.2  NT_011295.12  
Regulatory elements:
   Search for regulatory transcription factor binding sites for ZNF799
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for ZNF799

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF799


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.2   Ensembl cytogenetic band:  19p13.2   HGNC cytogenetic band: 19p13.2

ZNF799 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF799 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M012500:  view genomic region     (about GC identifiers)

Start:
12,500,828 bp from pter      End:
12,512,088 bp from pter
Size:
11,261 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ZN799_HUMAN, Q96GE5 (See protein sequence)
Recommended Name: Zinc finger protein 799  
Size: 643 amino acids; 74288 Da
Alternative splicing: 2 isoforms:  Q96GE5-1   Q96GE5-2   

Explore the universe of human proteins at neXtProt for ZNF799: NX_Q96GE5

Explore proteomics data for ZNF799 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ZNF799 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001074290.1  
    ENSEMBL proteins: 
     ENSP00000415278   ENSP00000411084   ENSP00000471169  
    Reactome Protein details: Q96GE5

    ZNF799 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR001909 Krueppel-associated_box
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q96GE5

    ProtoNet protein and cluster: Q96GE5

    UniProtKB/Swiss-Prot: ZN799_HUMAN, Q96GE5
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 18 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    Find genes that share domains with ZNF799           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN799_HUMAN, Q96GE5
    Function: May be involved in transcriptional regulation

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with ZNF799           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for ZNF799:
     Increased S DNA content 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ZNF799
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    miRNA
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    miRTarBase miRNAs that target ZNF799:
    hsa-mir-1 (MIRT023771)

    Block miRNA regulation of human, mouse, rat ZNF799 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate ZNF799:
    hsa-miR-188-3p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZN799_HUMAN, Q96GE5: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--

    Find genes that share ontologies with ZNF799           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ZNF799 About    
    See pathways by source

    SuperPathContained pathways About
    1Gene Expression
    Generic Transcription Pathway0.40
    Gene Expression0.40


    Find genes that share SuperPaths with ZNF799           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for ZNF799
        Generic Transcription Pathway


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF799
    Interactions:

        Search GeneGlobe Interaction Network for ZNF799

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--

    Find genes that share ontologies with ZNF799           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZNF799 (ZN799)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ZNF799 gene (2 alternative transcripts): 
    NM_203381.1  NM_001080821.2  

    Unigene Cluster for ZNF799:

    Zinc finger protein 799
    Hs.546637  [show with all ESTs]
    Unigene Representative Sequence: AL832890
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000460935 ENST00000419318(uc010dyt.3) ENST00000430385 ENST00000595766

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ZNF799 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate ZNF799:
    hsa-miR-188-3p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ZNF799
    Predesigned siRNA for gene silencing in human, mouse, rat ZNF799
    Clone
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    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat ZNF799
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ZNF799
      QuantiTect SYBR Green Assays in human, mouse, rat ZNF799
      QuantiFast Probe-based Assays in human, mouse, rat ZNF799

    Additional mRNA sequence: 

    AK027660.1 AL832890.1 BC009517.1 

    6 DOTS entries:

    DT.100749418  DT.100020380  DT.100749417  DT.65285526  DT.96085418  DT.121421433 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZNF799 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATAAGGAAAA
    ZNF799 Expression
    About this image

    ZNF799 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZNF799 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.546637
        Custom PCR Arrays for ZNF799
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF799

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ZNF799 gene from Selected species (see all 5)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfp7991 , 5 zinc finger protein 7991, 5 63.61(n)1
    49.68(a)1
      17 (17.98 cM)5
    2400641  NM_177359.41  NP_796333.31 
     328154555 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.158072 Transcribed sequence with weak similarity to protein more 80.46(n)    BM533522.1 


    ENSEMBL Gene Tree for ZNF799 (if available)
    TreeFam Gene Tree for ZNF799 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZNF799 gene
    ZNF6692  ZNF5642  ZNF4902  ZNF4412  ZNF625-ZNF202  ZNF8782  ENSG000002671792  ZNF142  
    ENSG000002697552  ENSG000001968262  ZNF7002  ZNF692  ZNF4402  ZNF4432  ZNF670-ZNF6952  ZNF442  
    ZNF4392  ZNF8232  ENSG000001884742  ZNF4912  ZNF5552  ENSG000002688702  ZNF7092  ZNF6252  
    ZNF202  ZNF7882  ZNF1012  ZNF7912  ZNF4422  ZNF4332  ZNF572  ZNF6272  
    ZNF5632  ENSG000002573552  ZNF1362  ZNF5562  ZNF7632  ENSG000002687442  ZNF8442  ZNF772  
    Selected SIMAP similar genes for ZNF799 using alignment to 3 protein entries:     ZN799_HUMAN (see all proteins) (see all similar genes):
    LOC101928664    ARL6IP5    C1orf143    HDGFRP2    RAD51    ZNF443
    RRM2B    BIRC3    KIAA1651    pp12301    AARSD1    ZNF442
    ZNF823    PARK2    TNNT1    VPS33A    AAMDC    ADCK1

    Find genes that share paralogs with ZNF799           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for ZNF799
    PGOHUM00000239154


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZNF799 (see all 395)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1113297741,2
    C,F--12500363(+) GGTACG/AATCCT 1 -- ds50011Minor allele frequency- A:0.50WA 2
    rs21128541,2
    C--12500413(-) TTGTTA/GTTTCT 1 -- ds50012Minor allele frequency- G:0.00NA 4
    rs1507980201,2
    --12500487(+) CTATAA/GCTAAG 1 -- ds50010--------
    rs1821704781,2
    --12500648(+) GCCTGC/TCAAGA 1 -- ds50010--------
    rs603783291,2
    C--12500747(+) TCATC-/ATTGTTAT 1 -- cds10--------
    rs2000838611,2
    C--12500747(+) ATCATC/TGTTAT 1 -- ds50010--------
    rs1863323411,2
    --12500800(+) TGGTAA/GGTGTT 1 -- ds50010--------
    rs29104331,2
    --12500828(+) CAATAG/TGTGAG 1 -- ut310--------
    rs1909386981,2
    --12500861(+) TGTTCC/TGGCTG 1 -- ut310--------
    rs1437418201,2
    --12500940(+) CATGAG/TTCCCT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for ZNF799 (12500828 - 12512088 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for ZNF799 (see all 11):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2718193CNV Deletion23290073
    esv2528408CNV Deletion19546169
    esv2718192CNV Deletion23290073
    esv2718194CNV Deletion23290073
    esv2421660CNV Duplication20811451
    dgv3732n71CNV Loss21882294
    nsv911073CNV Loss21882294
    nsv911068CNV Gain21882294
    esv21983CNV Gain19812545
    nsv911071CNV Gain21882294

    Human Gene Mutation Database (HGMD): ZNF799
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ZNF799
    DNA2.0 Custom Variant and Variant Library Synthesis for ZNF799

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with ZNF799           About GenesLikeMe


    Export disorders for ZNF799 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZNF799 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with ZNF799)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    2. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    3. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)
    4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    5. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (Nature 2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 90576 HGNC: 28071 Ensembl:ENSG00000196466 euGenes: HUgn90576 ECgene: ZNF799
    H-InvDB: ZNF799

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZNF799 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZNF799 gene:
    Search GeneIP for patents involving ZNF799

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