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ZNF793 Gene

protein-coding   GIFtS: 45
GCID: GC19P037997

Zinc Finger Protein 793

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger Protein 7931 2

External Ids:    HGNC: 331151   Entrez Gene: 3909272   Ensembl: ENSG000001882277   UniProtKB: Q6ZN113   

Export aliases for ZNF793 gene to outside databases

Previous GC identifers: GC19P042690 GC19P034448


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZNF793 Gene:
ZNF793 (zinc finger protein 793) is a protein-coding gene. An important paralog of this gene is ZNF175.

UniProtKB/Swiss-Prot: ZN793_HUMAN, Q6ZN11
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NT_011109.17  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZNF793 gene promoter:
         STAT5A   YY1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF793 promoter sequence
   Search Chromatin IP Primers for ZNF793

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF793


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.12   Ensembl cytogenetic band:  19q13.12   HGNC cytogenetic band: 19q13.12

ZNF793 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF793 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P037997:  view genomic region     (about GC identifiers)

Start:
37,997,841 bp from pter      End:
38,039,664 bp from pter
Size:
41,824 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ZN793_HUMAN, Q6ZN11 (See protein sequence)
Recommended Name: Zinc finger protein 793  
Size: 406 amino acids; 46927 Da
Sequence caution: Sequence=CAD97772.1; Type=Frameshift; Positions=291;
Secondary accessions: E9PGN4 Q7Z3Q9
Alternative splicing: 3 isoforms:  Q6ZN11-1   Q6ZN11-2   Q6ZN11-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ZNF793: NX_Q6ZN11

Explore proteomics data for ZNF793 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ZNF793 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001013681.2  
    ENSEMBL proteins: 
     ENSP00000468605   ENSP00000468286   ENSP00000467919   ENSP00000466645   ENSP00000466738  
     ENSP00000465900   ENSP00000466509   ENSP00000444355   ENSP00000396402  
    Reactome Protein details: Q6ZN11

    ZNF793 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR001909 Krueppel-associated_box
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q6ZN11

    ProtoNet protein and cluster: Q6ZN11

    1 Blocks protein domain: IPB001909 KRAB box

    UniProtKB/Swiss-Prot: ZN793_HUMAN, Q6ZN11
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 6 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    Find genes that share domains with ZNF793           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN793_HUMAN, Q6ZN11
    Function: May be involved in transcriptional regulation

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with ZNF793           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ZNF793
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    miRNA
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    hsa-mir-186-5p (MIRT045255), hsa-mir-99b-3p (MIRT038533)

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    Selected qRT-PCR Assays for microRNAs that regulate ZNF793 (see all 20):
    hsa-miR-607 hsa-miR-448 hsa-miR-200a hsa-miR-138-2* hsa-miR-548l hsa-miR-141 hsa-miR-204 hsa-miR-3613-3p
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZN793_HUMAN, Q6ZN11: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--

    Find genes that share ontologies with ZNF793           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ZNF793 About    
    See pathways by source

    SuperPathContained pathways About
    1Gene Expression
    Generic Transcription Pathway0.40
    Gene Expression0.40


    Find genes that share SuperPaths with ZNF793           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for ZNF793
        Generic Transcription Pathway


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF793
    Interactions:

        Search GeneGlobe Interaction Network for ZNF793

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--

    Find genes that share ontologies with ZNF793           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZNF793 (ZN793)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ZNF793 gene: 
    NM_001013659.2  

    Unigene Cluster for ZNF793:

    Zinc finger protein 793
    Hs.568010  [show with all ESTs]
    Unigene Representative Sequence: NM_001013659
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000587143 ENST00000586138 ENST00000588578 ENST00000587986 ENST00000589319
    ENST00000587490 ENST00000586187 ENST00000542455 ENST00000445217(uc010efm.3 uc010xts.2)

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate ZNF793 (see all 20):
    hsa-miR-607 hsa-miR-448 hsa-miR-200a hsa-miR-138-2* hsa-miR-548l hsa-miR-141 hsa-miR-204 hsa-miR-3613-3p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: ZNF793 (NM_001013659)
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    OriGene qSTAR qPCR primer pairs in human, mouse for ZNF793
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat ZNF793
      QuantiTect SYBR Green Assays in human, mouse, rat ZNF793
      QuantiFast Probe-based Assays in human, mouse, rat ZNF793

    Additional mRNA sequence: 

    AK131417.1 AK303740.1 BC150303.1 BX537524.1 

    10 DOTS entries:

    DT.102826128  DT.106276  DT.100743099  DT.40129196  DT.100742014  DT.311186  DT.91698205  DT.95312413 
    DT.40292341  DT.99933370 

    Selected AceView cDNA sequences (see all 133):

    BX647800 CK821801 BX115985 AL832315 AA321768 BX097888 AK122597 BC063448 
    AA905311 BX118256 AI023879 AI032287 AA781724 BE219465 AL832687 AK131388 
    CK430096 AL524892 AI803971 NM_152606 BX117928 N89873 AL518023 CR616392 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF793    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c
    SP1:                                          
    SP2:                          -               


    ECgene alternative splicing isoforms for ZNF793

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZNF793 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGGCAGGAGA
    ZNF793 Expression
    About this image

    ZNF793 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZNF793 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.568010
        Custom PCR Arrays for ZNF793
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF793

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of mammals.

    Orthologs for ZNF793 gene from Selected species (see all 3)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    dog
    (Canis familiaris)
    Mammalia ZNF7936
    zinc finger protein 793
    87(a)
    1 ↔ 1
    1(115832628-115854493)


    ENSEMBL Gene Tree for ZNF793 (if available)
    TreeFam Gene Tree for ZNF793 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZNF793 gene
    ZNF1752  ZNF6742  ZNF4872  ZNF5102  ZIM32  ZNF6142  ZNF1572  ZNF262  
    ZNF6132  ZNF812  ZNF6492  ENSG000002673602  ZNF7822  ZNF252  ZNF5682  ENSG000002365752  
    ENSG000002296312  ZNF5672  ZNF1822  ZNF37A2  ZNF2482  ZNF3002  ZNF3822  RBAK-RBAKDN2  
    Selected SIMAP similar genes for ZNF793 using alignment to 7 protein entries:     ZN793_HUMAN (see all proteins) (see all similar genes):
    ZNF320    ZNF577    ZFP90    ZNF525    ZNF283    ZNF761
    ZNF12    ZNF649    ZNF420    ZNF350    ZNF135    ZNF616
    ZNF677    ZNF519    ZNF780A    ZNF81    ZNF625-ZNF20    ZNF529

    Find genes that share paralogs with ZNF793           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for ZNF793
    PGOHUM00000242436


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZNF793 (see all 703)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1486144571,2
    --37995854(+) GGTCGA/GGAGTT 1 -- us2k10--------
    rs1850091051,2
    --37995860(+) GAGTTC/TGAGAC 1 -- us2k10--------
    rs1878199281,2
    C--37995951(+) CAGCTA/GCTCAG 1 -- us2k10--------
    rs1915632341,2
    --37995984(+) TTGAAC/TCCGGG 1 -- us2k10--------
    rs58279801,2
    C--37996063(+) GTCTC-/AAAAAA 1 -- us2k11Minor allele frequency- A:0.00NA 2
    rs1420367231,2
    --37996332(+) GGGTGA/TTACAC 1 -- us2k10--------
    rs72487331,2
    C,F,H--37996361(+) CAGCTA/CCTCCC 1 -- us2k122Minor allele frequency- C:0.37NS EA NA WA CSA 2348
    rs1843161401,2
    --37996425(+) GTCTCC/GGTATC 1 -- us2k10--------
    rs556495271,2
    C,F--37996482(+) TTAAGA/TCAGAA 1 -- us2k13Minor allele frequency- T:0.07WA 122
    rs1900354691,2
    --37996595(+) ACTACA/TTAAGA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ZNF793 (37997841 - 38039664 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for ZNF793:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv272929CNV Insertion20981092
    esv269267CNV Insertion20981092
    nsv2478CNV Loss18451855
    nsv833819CNV Gain17160897
    dgv1081e1CNV Complex17122850

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZNF793 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with ZNF793)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)
    2. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    3. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (Nature 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (Genome Res. 1996)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 390927 HGNC: 33115 AceView: ZNF540 Ensembl:ENSG00000188227 euGenes: HUgn390927
    ECgene: ZNF793 H-InvDB: ZNF793

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZNF793 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZNF793 gene:
    Search GeneIP for patents involving ZNF793

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

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