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ZNF792 Gene

protein-coding   GIFtS: 46
GCID: GC19M035447

Zinc Finger Protein 792

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger Protein 7921 2

External Ids:    HGNC: 247511   Entrez Gene: 1263752   Ensembl: ENSG000001808847   UniProtKB: Q3KQV33   

Export aliases for ZNF792 gene to outside databases

Previous GC identifers: GC19M040140 GC19M031955


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZNF792 Gene:
ZNF792 (zinc finger protein 792) is a protein-coding gene. An important paralog of this gene is ZNF549.

UniProtKB/Swiss-Prot: ZN792_HUMAN, Q3KQV3
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NT_011109.17  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZNF792 gene promoter:
         HSF2   HTF   XBP-1   Evi-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF792 promoter sequence
   Search Chromatin IP Primers for ZNF792

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF792


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.11   Ensembl cytogenetic band:  19q13.11   HGNC cytogenetic band: 19q13.11

ZNF792 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF792 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M035447:  view genomic region     (about GC identifiers)

Start:
35,447,258 bp from pter      End:
35,454,953 bp from pter
Size:
7,696 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ZN792_HUMAN, Q3KQV3 (See protein sequence)
Recommended Name: Zinc finger protein 792  
Size: 632 amino acids; 71577 Da
Sequence caution: Sequence=AAI01119.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAI01120.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAI01121.1;
Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: B4E333 Q495L1 Q495L3 Q8N932

Explore the universe of human proteins at neXtProt for ZNF792: NX_Q3KQV3

Explore proteomics data for ZNF792 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ZNF792 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_787068.3  
    ENSEMBL proteins: 
     ENSP00000385099   ENSP00000474130  
    Reactome Protein details: Q3KQV3

    ZNF792 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for ZNF792

     
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    antibodies-online proteins for ZNF792 

     
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    antibodies-online antibodies for ZNF792 (3 products) 

    ZNF792 Assay Products:

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    Cloud-Clone Corp. ELISAs for ZNF792
    Cloud-Clone Corp. CLIAs for ZNF792
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    antibodies-online kits for ZNF792 (2 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR001909 Krueppel-associated_box
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q3KQV3

    ProtoNet protein and cluster: Q3KQV3

    UniProtKB/Swiss-Prot: ZN792_HUMAN, Q3KQV3
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 13 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    Find genes that share domains with ZNF792           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN792_HUMAN, Q3KQV3
    Function: May be involved in transcriptional regulation

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with ZNF792           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for ZNF792

    miRNA
    Products:
        
    miRTarBase miRNAs that target ZNF792:
    hsa-mir-101-3p (MIRT027263), hsa-mir-7-1-3p (MIRT038681), hsa-mir-877-3p (MIRT037017), hsa-mir-1296-5p (MIRT036133), hsa-mir-484 (MIRT042135)

    Block miRNA regulation of human, mouse, rat ZNF792 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ZNF792 (see all 11):
    hsa-miR-4324 hsa-miR-125a-5p hsa-miR-4251 hsa-miR-551b* hsa-miR-125b hsa-miR-670 hsa-miR-544 hsa-miR-3134
    SwitchGear 3'UTR luciferase reporter plasmidZNF792 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat ZNF792

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector: ZNF792 (NM_175872)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ZNF792
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF792

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF792


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZN792_HUMAN, Q3KQV3: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--

    Find genes that share ontologies with ZNF792           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ZNF792 About    
    See pathways by source

    SuperPathContained pathways About
    1Gene Expression
    Generic Transcription Pathway0.40
    Gene Expression0.40


    Find genes that share SuperPaths with ZNF792           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for ZNF792
        Generic Transcription Pathway


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF792
    Interactions:

        Search GeneGlobe Interaction Network for ZNF792

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--

    Find genes that share ontologies with ZNF792           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZNF792 (ZN792)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ZNF792 gene: 
    NM_175872.4  

    Unigene Cluster for ZNF792:

    Zinc finger protein 792
    Hs.50405  [show with all ESTs]
    Unigene Representative Sequence: NM_175872
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000404801(uc002nxh.1) ENST00000605484
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ZNF792 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ZNF792 (see all 11):
    hsa-miR-4324 hsa-miR-125a-5p hsa-miR-4251 hsa-miR-551b* hsa-miR-125b hsa-miR-670 hsa-miR-544 hsa-miR-3134
    SwitchGear 3'UTR luciferase reporter plasmidZNF792 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ZNF792
    Predesigned siRNA for gene silencing in human, mouse, rat ZNF792
    Clone
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    OriGene clones in human, mouse for ZNF792 (see all 5)
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    GenScript: all cDNA clones in your preferred vector: ZNF792 (NM_175872)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ZNF792
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF792
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for ZNF792
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat ZNF792
      QuantiTect SYBR Green Assays in human, mouse, rat ZNF792
      QuantiFast Probe-based Assays in human, mouse, rat ZNF792

    Additional mRNA sequence: 

    AK095770.1 AK130901.1 AK304550.1 BC101118.1 BC101119.2 BC101120.1 

    2 DOTS entries:

    DT.210976  DT.91994156 

    Selected AceView cDNA sequences (see all 42):

    NM_175872 BQ024396 CR594544 AI472199 BU754425 AA283757 N72941 Z39872 
    AK095770 AI277539 BI772434 Z43806 CF146351 AA252229 BF110071 BX451858 
    BU686719 CB108971 BG255564 BX117208 W18184 BX416759 AK130901 AW173196 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZNF792 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCCCTTTACA
    ZNF792 Expression
    About this image

    ZNF792 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZNF792 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.50405
        Custom PCR Arrays for ZNF792
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF792

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of mammals.

    Orthologs for ZNF792 gene from Selected species (see all 3)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    dog
    (Canis familiaris)
    Mammalia ZNF7921 zinc finger protein 792 82.55(n)
    76.18(a)
      484586  XM_541700.4  XP_541700.4 


    ENSEMBL Gene Tree for ZNF792 (if available)
    TreeFam Gene Tree for ZNF792 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZNF792 gene
    ZNF5492  ENSG000002695332  ZNF4172  ENSG000002681332  ENSG000002681072  ZNF4162  ZNF172  ZNF5482  
    ZNF587B2  ZNF7732  ZIK12  ZNF1342  ZNF6712  ENSG000002681632  ZNF7722  ZNF5302  
    ZNF4192  ZNF5872  ZNF2112  ZNF7492  ZNF5512  ENSG000002687502  ZNF7762  ZNF5472  
    ZNF5842  ENSG000002690262  ZNF3042  ZNF1322  ZNF5862  ZNF4182  ZNF2562  ZNF5522  
    ZNF1542  
    Selected SIMAP similar genes for ZNF792 using alignment to 3 protein entries:     ZN792_HUMAN (see all proteins) (see all similar genes):
    ZNF78L1    ZFS-5    DKFZp686H10254    ZNF826P    ZSCAN21    DKFZp686N14223
    FLJ00301    HZF36    ZNF24    ZSCAN9    ZNF3    DKFZp666C237
    HZF30    ZFP41    kr-znf3    GLI4    ZFS-4    ZKSCAN8

    Find genes that share paralogs with ZNF792           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for ZNF792
    PGOHUM00000234288


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZNF792 (see all 273)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs601387461,2
    F--35446784(+) CAACAT/CTGATG 1 -- ds50011Minor allele frequency- C:0.03WA 118
    rs1881230041,2
    --35446930(+) GGGGAA/GGGGAA 1 -- ds50010--------
    rs350434441,2
    C,F--35447093(+) GTTAAG/CTATAT 1 -- ds50018Minor allele frequency- C:0.17NA CSA WA EA 366
    rs25460231,2
    C,F,A,H--35447135(+) ACCatA/Caaaaa 1 -- ds50017Minor allele frequency- C:0.32NA WA EA 366
    rs1435095101,2
    --35447235(+) ATGCTA/GCATGA 1 -- ds50010--------
    rs1928759991,2
    --35447338(+) ATCAAC/TGGTTT 1 -- ut310--------
    rs1844202501,2
    --35447361(+) AAGGAA/GGGAAT 1 -- ut310--------
    rs777656401,2
    C--35447404(+) GGATAC/TGTTCA 1 -- ut312Minor allele frequency- T:0.03CSA WA 120
    rs1471735191,2
    C--35447466(+) ACTTAC/TCAAAT 1 -- ut310--------
    rs1887949651,2
    --35447490(+) GCATGA/GCAATC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for ZNF792 (35447258 - 35454953 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for ZNF792: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ZNF792
    DNA2.0 Custom Variant and Variant Library Synthesis for ZNF792

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with ZNF792           About GenesLikeMe

    Genetic Association Database (GAD): ZNF792
    Human Genome Epidemiology (HuGE) Navigator: ZNF792 (1 document)

    Export disorders for ZNF792 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZNF792 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with ZNF792)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    2. Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1, 3 Bonaldo M.F.... Soares M.B. (Genome Res. 1996)
    3. Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes? (PubMed id 23314748)1 Nathan J.A....Goldberg A.L. (EMBO J. 2013)
    4. Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags. (PubMed id 16712791)1 Wang A.G....Kim N.S. (Biochem. Biophys. Res. Commun. 2006)
    5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (Nature 2004)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 126375 HGNC: 24751 AceView: FLJ38451 Ensembl:ENSG00000180884 euGenes: HUgn126375
    ECgene: ZNF792 H-InvDB: ZNF792

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZNF792 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZNF792 gene:
    Search GeneIP for patents involving ZNF792

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